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Aliases for CCT3 Gene

Aliases for CCT3 Gene

  • Chaperonin Containing TCP1 Subunit 3 2 3
  • Chaperonin Containing TCP1, Subunit 3 (Gamma) 2 3 5
  • TCP-1-Gamma 3 4
  • CCT-Gamma 3 4
  • HTRiC5 3 4
  • TRIC5 3 4
  • CCTG 3 4
  • TCP1 (T-Complex-1) Ring Complex, Polypeptide 5 3
  • T-Complex Protein 1, Gamma Subunit 3
  • PIG48 3

External Ids for CCT3 Gene

Previous HGNC Symbols for CCT3 Gene

  • TRIC5

Previous GeneCards Identifiers for CCT3 Gene

  • GC01M154147
  • GC01M152043
  • GC01M153056
  • GC01M153495
  • GC01M153091
  • GC01M154545
  • GC01M156278
  • GC01M127638

Summaries for CCT3 Gene

Entrez Gene Summary for CCT3 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

GeneCards Summary for CCT3 Gene

CCT3 (Chaperonin Containing TCP1 Subunit 3) is a Protein Coding gene. Diseases associated with CCT3 include myotonic disease and spinocerebellar ataxia 10. Among its related pathways are Transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CCT3 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT3 Gene

Genomics for CCT3 Gene

Regulatory Elements for CCT3 Gene

Promoters for CCT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCT3 Gene

Chromosome:
1
Start:
156,308,961 bp from pter
End:
156,367,873 bp from pter
Size:
58,913 bases
Orientation:
Minus strand

Genomic View for CCT3 Gene

Genes around CCT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT3 Gene

Proteins for CCT3 Gene

  • Protein details for CCT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49368-TCPG_HUMAN
    Recommended name:
    T-complex protein 1 subunit gamma
    Protein Accession:
    P49368
    Secondary Accessions:
    • A6NE14
    • Q5SZY1
    • Q9BR64

    Protein attributes for CCT3 Gene

    Size:
    545 amino acids
    Molecular mass:
    60534 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity).
    SequenceCaution:
    • Sequence=AAH08019.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT3 Gene

Proteomics data for CCT3 Gene at MOPED

Post-translational modifications for CCT3 Gene

  • Ubiquitination at Lys 21, Lys 31, Lys 44, Lys 48, Lys 78, Lys 249, Lys 354, Lys 427, Lys 502, and Lys 507
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CCT3 Gene

Domains & Families for CCT3 Gene

Gene Families for CCT3 Gene

Graphical View of Domain Structure for InterPro Entry

P49368

UniProtKB/Swiss-Prot:

TCPG_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT3: view

Function for CCT3 Gene

Molecular function for CCT3 Gene

GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1) subunit 3 (gamma),cytosolic,widely expressed in fetal and adult tissues,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
genes like me logo Genes that share phenotypes with CCT3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT3 Gene

Localization for CCT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT3 Gene COMPARTMENTS Subcellular localization image for CCT3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
plasma membrane 5
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
genes like me logo Genes that share ontologies with CCT3: view

Pathways & Interactions for CCT3 Gene

genes like me logo Genes that share pathways with CCT3: view

Gene Ontology (GO) - Biological Process for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046931 pore complex assembly IEA --
GO:0050821 protein stabilization IMP 25467444
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT3: view

No data available for SIGNOR curated interactions for CCT3 Gene

Drugs & Compounds for CCT3 Gene

(1) Drugs for CCT3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
genes like me logo Genes that share compounds with CCT3: view

Transcripts for CCT3 Gene

Unigene Clusters for CCT3 Gene

Chaperonin containing TCP1, subunit 3 (gamma):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:
SP2: - -
SP3: -

Relevant External Links for CCT3 Gene

GeneLoc Exon Structure for
CCT3
ECgene alternative splicing isoforms for
CCT3

Expression for CCT3 Gene

mRNA expression in normal human tissues for CCT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT3 Gene



SOURCE GeneReport for Unigene cluster for CCT3 Gene Hs.491494

genes like me logo Genes that share expression patterns with CCT3: view

Protein tissue co-expression partners for CCT3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT3 Gene

Orthologs for CCT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCT3 35
  • 92.97 (n)
  • 98.53 (a)
CCT3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT3 35
  • 92.11 (n)
  • 97.8 (a)
CCT3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct3 35
  • 89.72 (n)
  • 97.25 (a)
Cct3 16
Cct3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCT3 35
  • 99.57 (n)
  • 99.82 (a)
CCT3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct3 35
  • 90.09 (n)
  • 97.8 (a)
oppossum
(Monodelphis domestica)
Mammalia CCT3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCT3 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCT3 35
  • 75.51 (n)
  • 85.19 (a)
-- 36
  • 85 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CCT3 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cct3 35
  • 78.05 (n)
  • 88.13 (a)
MGC76259 35
African clawed frog
(Xenopus laevis)
Amphibia cct3-prov 35
zebrafish
(Danio rerio)
Actinopterygii cct3 35
  • 75.59 (n)
  • 85.69 (a)
cct3 36
  • 86 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9536 35
fruit fly
(Drosophila melanogaster)
Insecta Cctgamma 37
  • 68 (a)
Cctgamma 35
  • 67.6 (n)
  • 70.39 (a)
Cctgamma 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002759 35
  • 67.23 (n)
  • 73.12 (a)
worm
(Caenorhabditis elegans)
Secernentea F54A3.3 37
  • 50 (a)
cct-3 35
  • 60.56 (n)
  • 62.6 (a)
cct-3 36
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR314W 35
  • 59.08 (n)
  • 59.85 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22583g 35
  • 59.53 (n)
  • 60.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT3 35
  • 58.89 (n)
  • 60.61 (a)
CCT3 36
  • 59 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G26360 35
  • 60.27 (n)
  • 61.79 (a)
soybean
(Glycine max)
eudicotyledons Gma.6692 35
barley
(Hordeum vulgare)
Liliopsida Hv.11063 35
rice
(Oryza sativa)
Liliopsida Os.12204 35
Os02g0247200 35
  • 59.92 (n)
  • 62.76 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2554 35
corn
(Zea mays)
Liliopsida Zm.16810 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2484 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01843 35
  • 63.29 (n)
  • 65.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct3 35
  • 59.3 (n)
  • 63.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
CSA.2701 36
  • 69 (a)
OneToMany
Species with no ortholog for CCT3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT3 Gene

ENSEMBL:
Gene Tree for CCT3 (if available)
TreeFam:
Gene Tree for CCT3 (if available)

Paralogs for CCT3 Gene

Pseudogenes.org Pseudogenes for CCT3 Gene

genes like me logo Genes that share paralogs with CCT3: view

No data available for Paralogs for CCT3 Gene

Variants for CCT3 Gene

Sequence variations from dbSNP and Humsavar for CCT3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2230194 - 156,311,180(-) GCAAC(C/T)TCCAG nc-transcript-variant, reference, missense
rs8035 -- 156,309,008(-) GGTTT(C/T)CATTT nc-transcript-variant, utr-variant-3-prime
rs10356 -- 156,309,009(-) AGGTT(A/T)CCATT nc-transcript-variant, utr-variant-3-prime
rs2249790 -- 156,317,569(-) AATCA(A/G)TGTCT intron-variant
rs2250265 -- 156,321,574(+) CATAA(C/T)GCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT3 Gene

Variant ID Type Subtype PubMed ID
nsv872471 CNV Loss 21882294
esv1449360 CNV Insertion 17803354

Variation tolerance for CCT3 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT3 Gene

HapMap Linkage Disequilibrium report
CCT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT3 Gene

Disorders for CCT3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
myotonic disease
  • myotonic disorders
spinocerebellar ataxia 10
  • spinocerebellar ataxia type 10
- elite association - COSMIC cancer census association via MalaCards
Search CCT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCT3

Genetic Association Database (GAD)
CCT3
Human Genome Epidemiology (HuGE) Navigator
CCT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT3
genes like me logo Genes that share disorders with CCT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT3 Gene

Publications for CCT3 Gene

  1. Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. (PMID: 8573069) Walkley N.A. … Malik A.N. (Biochem. J. 1996) 3 4 23 67
  2. cDNA encoding a novel TCP1-related protein. (PMID: 8110840) Joly E.C. … Bibor-Hardy V. (Biochim. Biophys. Acta 1994) 2 3
  3. Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization. (PMID: 8001976) Sevigny G. … Lemieux N. (Genomics 1994) 3 23
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  5. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3

Products for CCT3 Gene

Sources for CCT3 Gene

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