Aliases for CCT3 Gene
External Ids for CCT3 Gene
Previous HGNC Symbols for CCT3 Gene
Previous GeneCards Identifiers for CCT3 Gene
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
GeneCards Summary for CCT3 Gene
CCT3 (Chaperonin Containing TCP1 Subunit 3) is a Protein Coding gene. Diseases associated with CCT3 include Spinocerebellar Ataxia 10. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding.
UniProtKB/Swiss-Prot for CCT3 Gene
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.