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Aliases for CCT3 Gene

Aliases for CCT3 Gene

  • Chaperonin Containing TCP1, Subunit 3 (Gamma) 2 3
  • TRIC5 3 4 6
  • TCP-1-Gamma 3 4
  • CCT-Gamma 3 4
  • HTRiC5 3 4
  • CCTG 3 4
  • TCP1 (T-Complex-1) Ring Complex, Polypeptide 5 3
  • T-Complex Protein 1, Gamma Subunit 3
  • T-Complex Protein 1 Subunit Gamma 3
  • PIG48 3

External Ids for CCT3 Gene

Previous HGNC Symbols for CCT3 Gene

  • TRIC5

Previous GeneCards Identifiers for CCT3 Gene

  • GC01M154147
  • GC01M152043
  • GC01M153056
  • GC01M153495
  • GC01M153091
  • GC01M154545
  • GC01M156278
  • GC01M127638

Summaries for CCT3 Gene

Entrez Gene Summary for CCT3 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

GeneCards Summary for CCT3 Gene

CCT3 (Chaperonin Containing TCP1, Subunit 3 (Gamma)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for CCT3 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT3 Gene

Genomics for CCT3 Gene

Regulatory Elements for CCT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCT3 Gene

Start:
156,308,961 bp from pter
End:
156,367,873 bp from pter
Size:
58,913 bases
Orientation:
Minus strand

Genomic View for CCT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT3 Gene

Proteins for CCT3 Gene

  • Protein details for CCT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49368-TCPG_HUMAN
    Recommended name:
    T-complex protein 1 subunit gamma
    Protein Accession:
    P49368
    Secondary Accessions:
    • A6NE14
    • Q5SZY1
    • Q9BR64

    Protein attributes for CCT3 Gene

    Size:
    545 amino acids
    Molecular mass:
    60534 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity).
    SequenceCaution:
    • Sequence=AAH08019.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT3 Gene

Proteomics data for CCT3 Gene at MOPED

Post-translational modifications for CCT3 Gene

  • Ubiquitination at Lys21, Lys31, Lys44, Lys48, Lys78, Lys248, Lys249, Lys354, Lys381, Lys427, Lys502, and Lys507
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCT3 Gene

Domains for CCT3 Gene

Gene Families for CCT3 Gene

HGNC:
  • CHAP :Heat Shock Proteins / Chaperonins

Graphical View of Domain Structure for InterPro Entry

P49368

UniProtKB/Swiss-Prot:

TCPG_HUMAN :
  • P49368
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT3: view

Function for CCT3 Gene

Molecular function for CCT3 Gene

GENATLAS Biochemistry: chaperonin containing TCP1 (T complex protein 1) subunit 3 (gamma),cytosolic,widely expressed in fetal and adult tissues,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Ontology (GO) - Molecular Function for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12620389
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with CCT3: view
genes like me logo Genes that share phenotypes with CCT3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCT3 Gene

Localization for CCT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT3 Gene COMPARTMENTS Subcellular localization image for CCT3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 4
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex IDA 23011926
GO:0005856 cytoskeleton TAS 8001976
genes like me logo Genes that share ontologies with CCT3: view

Pathways for CCT3 Gene

genes like me logo Genes that share pathways with CCT3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0046931 pore complex assembly IEA --
GO:0051084 de novo posttranslational protein folding TAS --
genes like me logo Genes that share ontologies with CCT3: view

Compounds for CCT3 Gene

(2) Drugbank Compounds for CCT3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5'-Diphosphate
20398-34-9 target
Phosphoaminophosphonic Acid-Adenylate Ester
target
genes like me logo Genes that share compounds with CCT3: view

Transcripts for CCT3 Gene

Unigene Clusters for CCT3 Gene

Chaperonin containing TCP1, subunit 3 (gamma):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:
SP2: - -
SP3: -

Relevant External Links for CCT3 Gene

GeneLoc Exon Structure for
CCT3
ECgene alternative splicing isoforms for
CCT3

Expression for CCT3 Gene

mRNA expression in normal human tissues for CCT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT3 Gene

SOURCE GeneReport for Unigene cluster for CCT3 Gene Hs.491494

genes like me logo Genes that share expressions with CCT3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT3 Gene

Orthologs for CCT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT3 35
  • 99.57 (n)
  • 99.82 (a)
CCT3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCT3 35
  • 92.97 (n)
  • 98.53 (a)
CCT3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT3 35
  • 92.11 (n)
  • 97.8 (a)
CCT3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct3 35
  • 89.72 (n)
  • 97.25 (a)
Cct3 16
Cct3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCT3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCT3 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct3 35
  • 90.09 (n)
  • 97.8 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 85 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
CCT3 35
  • 75.51 (n)
  • 85.19 (a)
lizard
(Anolis carolinensis)
Reptilia CCT3 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cct3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cct3 35
  • 78.05 (n)
  • 88.13 (a)
MGC76259 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9536 35
zebrafish
(Danio rerio)
Actinopterygii cct3 35
  • 75.59 (n)
  • 85.69 (a)
cct3 36
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002759 35
  • 67.23 (n)
  • 73.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cctgamma 35
  • 67.6 (n)
  • 70.39 (a)
Cctgamma 36
  • 69 (a)
OneToOne
Cctgamma 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-3 35
  • 60.56 (n)
  • 62.6 (a)
cct-3 36
  • 60 (a)
OneToOne
F54A3.3 37
  • 50 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR314W 35
  • 59.08 (n)
  • 59.85 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT3 35
  • 58.89 (n)
  • 60.61 (a)
CCT3 36
  • 59 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22583g 35
  • 59.53 (n)
  • 60.23 (a)
soybean
(Glycine max)
eudicotyledons Gma.6692 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G26360 35
  • 60.27 (n)
  • 61.79 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11063 35
corn
(Zea mays)
Liliopsida Zm.16810 35
rice
(Oryza sativa)
Liliopsida Os.12204 35
Os02g0247200 35
  • 59.92 (n)
  • 62.76 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2554 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01843 35
  • 63.29 (n)
  • 65.67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct3 35
  • 59.3 (n)
  • 63.81 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2484 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
CSA.2701 36
  • 69 (a)
OneToMany
Species with no ortholog for CCT3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT3 Gene

ENSEMBL:
Gene Tree for CCT3 (if available)
TreeFam:
Gene Tree for CCT3 (if available)

Paralogs for CCT3 Gene

Pseudogenes.org Pseudogenes for CCT3 Gene

genes like me logo Genes that share paralogs with CCT3: view

No data available for Paralogs for CCT3 Gene

Variants for CCT3 Gene

Sequence variations from dbSNP and Humsavar for CCT3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8035 -- 156,309,008(-) GGTTT(C/T)CATTT utr-variant-3-prime, nc-transcript-variant
rs10356 -- 156,309,009(-) AGGTT(A/T)CCATT utr-variant-3-prime, nc-transcript-variant
rs2230194 - 156,311,180(-) GCAAC(C/T)TCCAG reference, missense, nc-transcript-variant
rs2230195 -- 156,311,178(-) AACCT(C/T)CAGGA reference, synonymous-codon, nc-transcript-variant
rs2230196 -- 156,309,177(-) CTTCA(A/C)TGCAC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT3 Gene

Variant ID Type Subtype PubMed ID
nsv872471 CNV Loss 21882294
esv1449360 CNV Insertion 17803354

Relevant External Links for CCT3 Gene

HapMap Linkage Disequilibrium report
CCT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT3 Gene

Disorders for CCT3 Gene

Relevant External Links for CCT3

Genetic Association Database (GAD)
CCT3
Human Genome Epidemiology (HuGE) Navigator
CCT3
genes like me logo Genes that share disorders with CCT3: view

No data available for UniProtKB/Swiss-Prot for CCT3 Gene

Publications for CCT3 Gene

  1. Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization. (PMID: 8001976) Sevigny G. … Lemieux N. (Genomics 1994) 3 4 23
  2. Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. (PMID: 8573069) Walkley N.A. … Malik A.N. (Biochem. J. 1996) 3 4 23
  3. cDNA encoding a novel TCP1-related protein. (PMID: 8110840) Joly E.C. … Bibor-Hardy V. (Biochim. Biophys. Acta 1994) 2 3
  4. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PMID: 14532270) Imai Y. … Takahashi R. (J. Biol. Chem. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CCT3 Gene

Sources for CCT3 Gene

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