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CCT3 Gene(Protein Coding)

Chaperonin Containing TCP1 Subunit 3

GCID:
GC01M156308
GIFtS:
58
Genes Participants
UDN Logo

Aliases for CCT3 Gene

Aliases for CCT3 Gene

  • Chaperonin Containing TCP1 Subunit 3 2 3 5
  • Chaperonin Containing TCP1, Subunit 3 (Gamma) 2 3
  • TCP-1-Gamma 3 4
  • CCT-Gamma 3 4
  • HTRiC5 3 4
  • TRIC5 3 4
  • CCTG 3 4
  • TCP1 (T-Complex-1) Ring Complex, Polypeptide 5 3
  • T-Complex Protein 1, Gamma Subunit 3
  • T-Complex Protein 1 Subunit Gamma 3
  • PIG48 3

External Ids for CCT3 Gene

Previous HGNC Symbols for CCT3 Gene

  • TRIC5

Previous GeneCards Identifiers for CCT3 Gene

  • GC01M154147
  • GC01M152043
  • GC01M153056
  • GC01M153495
  • GC01M153091
  • GC01M154545
  • GC01M156278
  • GC01M127638

Summaries for CCT3 Gene

Entrez Gene Summary for CCT3 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

GeneCards Summary for CCT3 Gene

CCT3 (Chaperonin Containing TCP1 Subunit 3) is a Protein Coding gene. Diseases associated with CCT3 include Spinocerebellar Ataxia 10 and Immature Cataract. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Chaperonin-mediated protein folding. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CCT3 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT3 Gene

Genomics for CCT3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CCT3 Gene

Enhancers for CCT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G156145 2 FANTOM5 Ensembl ENCODE dbSUPER 10 +218.5 218520 7.7 HDGF PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC25A44 ENSG00000252236 MEX3A LMNA BGLAP PAQR6 TSACC CCT3 SMG5 ARHGEF2
GH01G156111 1.9 FANTOM5 ENCODE dbSUPER 10.4 +246.5 246484 19.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 KIAA0907 MSTO2P ENSG00000271267 RRNAD1 LMNA ASH1L BGLAP LOC246784 SYT11 MEX3A
GH01G156281 1.8 FANTOM5 ENCODE dbSUPER 10.8 +84.6 84616 4.4 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 GLMP SMG5 SLC25A44 PAQR6 BGLAP ENSG00000252236 SEMA4A TSACC CCT3 KIAA0907
GH01G156153 1.6 Ensembl ENCODE dbSUPER 10 +212.9 212892 3.5 HDGF FOXA2 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 SLC25A44 ENSG00000252236 MEX3A LMNA BGLAP PAQR6 TSACC CCT3 GC01P156159 GC01P156160
GH01G156569 1.4 FANTOM5 ENCODE 10.6 -203.7 -203671 3.3 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF143 FOS KLF13 SP3 NAXE MEF2D MSTO2P BCAN CCT3 TSACC GPATCH4 TTC24 IQGAP3 GC01P156524
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCT3 on UCSC Golden Path with GeneCards custom track

Promoters for CCT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014189 -1427 201 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP5

Transcription factor binding sites by QIAGEN in the CCT3 gene promoter:

Genomic Location for CCT3 Gene

Chromosome:
1
Start:
156,308,961 bp from pter
End:
156,367,873 bp from pter
Size:
58,913 bases
Orientation:
Minus strand

Genomic View for CCT3 Gene

Genes around CCT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCT3 Gene

Proteins for CCT3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49368-TCPG_HUMAN
    Recommended name:
    T-complex protein 1 subunit gamma
    Protein Accession:
    P49368
    Secondary Accessions:
    • A6NE14
    • Q5SZY1
    • Q9BR64

    Protein attributes for CCT3 Gene

    Size:
    545 amino acids
    Molecular mass:
    60534 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity).
    SequenceCaution:
    • Sequence=AAH08019.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT3 Gene

Protein Expression for CCT3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCT3 Gene

  • Ubiquitination at Lys21, posLast=3131, posLast=4444, Lys48, posLast=7878, Lys249, Lys354, posLast=427427, Lys502, and Lys507
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCT3 Gene

Domains & Families for CCT3 Gene

Gene Families for CCT3 Gene

HGNC:

Protein Domains for CCT3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49368

UniProtKB/Swiss-Prot:

TCPG_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT3: view

Function for CCT3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CCT3 Gene

GENATLAS Biochemistry:
chaperonin containing TCP1 (T complex protein 1) subunit 3 (gamma),cytosolic,widely expressed in fetal and adult tissues,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Ontology (GO) - Molecular Function for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 12620389
GO:0005524 ATP binding IEA --
GO:0044183 protein binding involved in protein folding IPI 25467444
GO:0051082 unfolded protein binding IBA,IEA --
genes like me logo Genes that share ontologies with CCT3: view
genes like me logo Genes that share phenotypes with CCT3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT3 Gene

Localization for CCT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0005832 chaperonin-containing T-complex TAS 25467444
GO:0005856 cytoskeleton TAS 8001976
genes like me logo Genes that share ontologies with CCT3: view

Pathways & Interactions for CCT3 Gene

genes like me logo Genes that share pathways with CCT3: view

Gene Ontology (GO) - Biological Process for CCT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS,IEA --
GO:0006458 de novo protein folding IBA --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0046931 pore complex assembly IEA --
genes like me logo Genes that share ontologies with CCT3: view

No data available for SIGNOR curated interactions for CCT3 Gene

Drugs & Compounds for CCT3 Gene

Products:

  1. Drug

(1) Drugs for CCT3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
genes like me logo Genes that share compounds with CCT3: view

Transcripts for CCT3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CCT3 Gene

(3) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(2308) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCT3 Gene

Chaperonin containing TCP1, subunit 3 (gamma):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:
SP2: - -
SP3: -

Relevant External Links for CCT3 Gene

GeneLoc Exon Structure for
CCT3
ECgene alternative splicing isoforms for
CCT3

Expression for CCT3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCT3 Gene

mRNA expression in normal human tissues for CCT3 Gene
mRNA expression by BioGPS for CCT3 GenemRNA expression by GTEx for CCT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCT3 Gene



Protein tissue co-expression partners for CCT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCT3 Gene:

CCT3

SOURCE GeneReport for Unigene cluster for CCT3 Gene:

Hs.491494

Evidence on tissue expression from TISSUES for CCT3 Gene

  • Lung(5)
  • Nervous system(5)
  • Kidney(4.9)
  • Liver(4.8)
  • Skin(4.7)
  • Intestine(4.6)
  • Eye(4.5)
  • Lymph node(4.4)
  • Muscle(4.1)
  • Pancreas(3.9)
  • Heart(3.5)
  • Blood(3.4)
  • Stomach(3.3)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CCT3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT3 Gene

Orthologs for CCT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCT3 34 35
  • 99.57 (n)
cow
(Bos Taurus)
 Mammalia CCT3 34 35
  • 92.97 (n)
dog
(Canis familiaris)
 Mammalia CCT3 34 35
  • 92.11 (n)
rat
(Rattus norvegicus)
 Mammalia Cct3 34
  • 90.09 (n)
oppossum
(Monodelphis domestica)
 Mammalia CCT3 35
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cct3 34 16 35
  • 89.72 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CCT3 35
  • 87 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves -- 35
  • 85 (a)
 OneToMany
CCT3 34
  • 75.51 (n)
-- 35
  • 57 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia CCT3 35
  • 88 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cct3 34
  • 78.05 (n)
MGC76259 34
African clawed frog
(Xenopus laevis)
 Amphibia cct3-prov 34
zebrafish
(Danio rerio)
 Actinopterygii cct3 34 35
  • 75.59 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9536 34
fruit fly
(Drosophila melanogaster)
 Insecta Cctgamma 36 34 35
  • 67.6 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002759 34
  • 67.23 (n)
worm
(Caenorhabditis elegans)
 Secernentea cct-3 34 35
  • 60.56 (n)
F54A3.3 36
  • 50 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F22583g 34
  • 59.53 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGR314W 34
  • 59.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CCT3 34 35
  • 58.89 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT5G26360 34
  • 60.27 (n)
soybean
(Glycine max)
 eudicotyledons Gma.6692 34
rice
(Oryza sativa)
 Liliopsida Os02g0247200 34
  • 59.92 (n)
Os.12204 34
barley
(Hordeum vulgare)
 Liliopsida Hv.11063 34
wheat
(Triticum aestivum)
 Liliopsida Ta.2554 34
corn
(Zea mays)
 Liliopsida Zm.16810 34
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 70 (a)
 OneToMany
CSA.2701 35
  • 69 (a)
 OneToMany
bread mold
(Neurospora crassa)
 Ascomycetes NCU01843 34
  • 63.29 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes cct3 34
  • 59.3 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.2484 34
Species where no ortholog for CCT3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT3 Gene

ENSEMBL:
Gene Tree for CCT3 (if available)
TreeFam:
Gene Tree for CCT3 (if available)

Paralogs for CCT3 Gene

(23) SIMAP similar genes for CCT3 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for CCT3 Gene

genes like me logo Genes that share paralogs with CCT3: view

No data available for Paralogs for CCT3 Gene

Variants for CCT3 Gene

Sequence variations from dbSNP and Humsavar for CCT3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000039263 -- 156,322,999(+) TGTAC(A/T)ACTTG intron-variant
rs1000111108 -- 156,322,492(+) CCCCC(C/T)GCCAC intron-variant
rs1000349819 -- 156,309,879(+) TAAAA(A/C)TAGAA intron-variant
rs1000378015 -- 156,326,527(+) TGCCT(A/G)TATTC intron-variant
rs1000413523 -- 156,322,719(+) CCAGG(A/C)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT3 Gene

Variant ID Type Subtype PubMed ID
esv1449360 CNV insertion 17803354
esv3587635 CNV gain 21293372
nsv1113185 CNV deletion 24896259
nsv1122409 CNV deletion 24896259

Variation tolerance for CCT3 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT3 Gene

Disorders for CCT3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCT3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 10
  • spinocerebellar ataxia type 10
immature cataract
  • incipient cataract
- elite association - COSMIC cancer census association via MalaCards
Search CCT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCT3

Genetic Association Database (GAD)
CCT3
Human Genome Epidemiology (HuGE) Navigator
CCT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT3
genes like me logo Genes that share disorders with CCT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT3 Gene

Publications for CCT3 Gene

  1. Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. (PMID: 8573069) Walkley N.A. … Malik A.N. (Biochem. J. 1996) 3 4 22 64
  2. Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization. (PMID: 8001976) Sevigny G. … Lemieux N. (Genomics 1994) 3 4 22 64
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CCT3 Gene

Sources for CCT3 Gene

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