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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCT3 Gene

protein-coding   GIFtS: 63
GCID: GC01M156278

chaperonin containing TCP1, subunit 3 (gamma)


(Previous symbol: TRIC5)
 Explore 14 diseases affiliated with
CCT3 via our new
 Human Malady Compendium 
Biological research products
for CCT3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chaperonin Containing TCP1, Subunit 3 (Gamma)1 2     Cctg1
TRIC51 2 3 5     PIG482
CCT-Gamma1     T-Complex Protein 1 Subunit Gamma2
CCTG2 3     T-Complex Protein 1, Gamma Subunit2
TCP-1-Gamma1     TCP1 (T-Complex-1) Ring Complex, Polypeptide 52
HTRiC51     

External Ids:    HGNC: 16161   Entrez Gene: 72032   Ensembl: ENSG000001634687   OMIM: 6001145   UniProtKB: P493683   

Export aliases for CCT3 gene to outside databases

Previous GC identifers: GC01M154147 GC01M152043 GC01M153056 GC01M153495 GC01M153091 GC01M154545 GC01M127638


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCT3:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex
(CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each
containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in
an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional
splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on
chromosome 8. (provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may
play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.
Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCT3 gene promoter:
         AML1a   Egr-1   Nkx5-1   MEF-2A   CBF-B   CBF-A   ARP-1   aMEF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q23

CCT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156278:  view genomic region     (about GC identifiers)

Start:
156,278,752 bp from pter      End:
156,337,664 bp from pter
Size:
58,913 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368 (See protein sequence)
Recommended Name: T-complex protein 1 subunit gamma  
Size: 545 amino acids; 60534 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAH08019.1; Type=Erroneous initiation;
Secondary accessions: A6NE14 Q5SZY1 Q9BR64
Alternative splicing: 2 isoforms:  P49368-1   P49368-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT3: NX_P49368

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49368

  • CCT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008800.1  NP_005989.3  

    ENSEMBL proteins: 
     ENSP00000295688   ENSP00000357242   ENSP00000357241   ENSP00000357245   ENSP00000431543  
     ENSP00000413308   ENSP00000434232   ENSP00000434481   ENSP00000388799   ENSP00000435026  
     ENSP00000413431   ENSP00000357244  
    Reactome Protein details: P49368
    Human Recombinant Protein Products: 
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    Novus Biologicals CCT3 Protein
    Novus Biologicals CCT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CCT3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--
    GO:0005856cytoskeleton TAS8001976
    GO:0005874microtubule IDA--


    CCT3 for ontologies           About GeneDecksing



    CCT3 Antibody Products: 
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    ThermoFisher Antibodies for CCT3

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    Uscn ELISAs and CLIAs for CCT3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CCT3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017998 Chaperone_TCP-1
     IPR012719 Chap_CCT_gamma
     IPR002194 Chaperonin_TCP-1_CS
     IPR002423 Cpn60/TCP-1

    Graphical View of Domain Structure for InterPro Entry P49368

    ProtoNet protein and cluster: P49368

    2 Blocks protein families:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368
    Similarity: Belongs to the TCP-1 chaperonin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may
    play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.
    Known to play a role, in vitro, in the folding of actin and tubulin

         Genatlas biochemistry entry for CCT3:
    chaperonin containing TCP1 (T complex protein 1) subunit 3 (gamma),cytosolic,widely expressed in fetal and adult
    tissues,TF55/TCP-1 family

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CCT3 (see all 10):
    hsa-miR-3688-3p hsa-miR-522 hsa-miR-324-3p hsa-miR-224* hsa-miR-105 hsa-miR-223 hsa-miR-338-5p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCCT3 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CCT3
    OriGene siRNA: CCT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCT3

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12620389
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding IEA--


    CCT3 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for CCT3:
     Cell division defect  Increased G2M DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of tubulin folding intermediates by CCT/TriC
    Formation of tubulin folding intermediates by CCT/TriC1.00
    Prefoldin mediated transfer of substrate to CCT/TriC0.70
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.74
    Folding of actin by CCT/TriC0.38
    2Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding1.00
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    3Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation1.00
    Cell cycle_Role of APC in cell cycle regulation0.98
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CCT3
        Cell cycle Role of APC in cell cycle regulation


    1 GeneGo (Thomson Reuters) Pathway for CCT3
        Cell cycle Role of APC in cell cycle regulation

    5/8        Reactome Pathways for CCT3 (see all 8)
        Formation of tubulin folding intermediates by CCT/TriC
    Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Prefoldin mediated transfer of substrate to CCT/TriC
    Metabolism of proteins



    CCT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1004 Interacting proteins for CCT3 (P493681, 2, 3 ENSP000003572444) via UniProtKB, MINT, STRING, and/or I2D (see all 1004)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=4 STRING: ENSP00000317334
    CCT4P509912, 3, ENSP000003779584MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=2 STRING: ENSP00000377958
    CCT7Q998322, 3, ENSP000002580914MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=1 STRING: ENSP00000258091
    ENSG00000258947Q135092, 3MINT-7945693 MINT-8415355 I2D: score=1 
    SF3B1O755332, 3, ENSP000003353214MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000335321
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--


    CCT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCT3

    2 DrugBank Compounds for CCT3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about CCT3 / TCPG 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCT3 gene (3 alternative transcripts): 
    NM_001008800.2  NM_005998.4  NM_001008883.1  

    Unigene Cluster for CCT3:

    Chaperonin containing TCP1, subunit 3 (gamma)
    Hs.491494  [show with all ESTs]
    Unigene Representative Sequence: NR_036564
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465714 ENST00000295688(uc010phj.2 uc010phk.2 uc001fol.2 uc001fon.2 uc010phl.2)
    ENST00000368259 ENST00000368258 ENST00000480049 ENST00000368262 ENST00000472765
    ENST00000413555 ENST00000496684 ENST00000533194 ENST00000463132 ENST00000490221
    ENST00000446905 ENST00000478640 ENST00000415548 ENST00000368256 ENST00000489870
    ENST00000368261

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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CCT3 (see all 10):
    hsa-miR-3688-3p hsa-miR-522 hsa-miR-324-3p hsa-miR-224* hsa-miR-105 hsa-miR-223 hsa-miR-338-5p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCCT3 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB208882.1 AK126400.1 AK293477.1 AK300765.1 AK308023.1 AK315923.1 AK316387.1 AL833197.1 
    AY524046.1 BC006501.2 BC008019.1 NR_036564.1 NR_036565.1 U17104.1 X74801.1 

    24/61 DOTS entries (see all 61):

    DT.97861030  DT.92053803  DT.92472159  DT.100045579  DT.100689696  DT.95351547  DT.95351599  DT.121427176 
    DT.100874374  DT.100689675  DT.100689683  DT.121427005  DT.100689688  DT.100689702  DT.92472168  DT.92472182 
    DT.121427032  DT.121427179  DT.121427060  DT.121426945  DT.121426934  DT.95143909  DT.97861032  DT.100689691 

    24/2308 AceView cDNA sequences (see all 2308):

    BE258234 BQ639501 AA112201 AI095588 BQ071046 BG385479 BU730853 BQ073644 
    BG327440 CA422487 BE910028 BG769759 BQ639386 BE871654 BQ654206 BU070758 
    BM661545 AL517485 BQ925970 AU125323 BE303014 CD655298 BU165057 BF026048 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCT3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                                                        
    SP2:                                      -     -                                                                           
    SP3:                                                                                -                                       


    ECgene alternative splicing isoforms for CCT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAATTCTTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CCT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCT3

    SOURCE GeneReport for Unigene cluster: Hs.491494
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCT3: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT3 gene from 8/40 species (see all 40)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia CCT36
    --
    88(a)
    1 ↔ 1
    AAWZ02036469(10991-26091)
    African clawed frog
    (Xenopus laevis)
    Amphibia cct3-prov2 chaperonin containing TCP-1 complex gamma chain 79.31(n)    BC048365.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cct32 chaperonin containing TCP1, subunit 3 (gamma) 77.37(n)   192327  BC053271.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cct&ggr;3
    Cctgamma1
    protein folding chaperonin ATPase3
    CCTgamma-like1
    68(a)3
    67.66(n)1
    70.39(a)1
      3 89D63
    420291  NM_001202307.11  NP_001189236.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F54A3.33
    cct-31
    Protein CCT-31 50(a)3
    60.56(n)1
    62.6(a)1
      II(2233549-2242578)3
    1735811  NM_061817.41  NP_494218.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT3(YJL014W)4
    CCT31
    Subunit of the cytosolic chaperonin Cct ring complex, more4
    Cct3p1
    58.89(n)1
    60.61(a)1
      10(407558-409162)4
    8534381, 4  NP_012520.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G263601 TCP-1/cpn60 chaperonin family protein 60.27(n)
    61.79(a)
      832705  NM_122537.3  NP_198008.1 
    rice
    (Oryza sativa)
    Liliopsida Os.122042 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.64(n)    AK069949.1 


    ENSEMBL Gene Tree for CCT3 (if available)
    TreeFam Gene Tree for CCT3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCT3 gene
    18/26 SIMAP similar genes for CCT3 using alignment to 10 protein entries:     TCPG_HUMAN (see all proteins) (see all similar genes):
    DNAPTP3    KIAA1651    LRRC37A3    OK/SW-cl.41    PODXL    TMEM135
    ZNF195    FAM138A    FAM138B    FAM138C    FAM138F    PLA2G15
    ZNF843    FAM138D    APCDD1    ZNF573    BCKDHA    AHSA1

    CCT3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCT3
    PGOHUM00000249580


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/529 NCBI SNPs in CCT3 are shown (see all 529    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390236811,2
    --156278264(+) AGAGGC/TCTGAC 4 -- ds50010--------
    rs67004171,2
    C,--156278419(+) TGTCCA/TTTAGG 4 -- ds50010--------
    rs1918870851,2
    C,--156278473(+) ACAACC/TACATA 4 -- ds50010--------
    rs1444570631,2
    --156278537(+) CAAAAC/TGGTGC 4 -- ds50010--------
    rs1484250491,2
    --156278599(+) CAAAAC/TTTACT 4 -- ds50010--------
    rs1815677131,2
    --156278747(+) AACACA/GTAACA 4 -- ds50010--------
    rs1155324191,2
    C,F,--156278754(+) AACAAC/TTTTCT 4 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.03WA 118
    rs80351,2
    --156278799(-) GGTTTC/TCATTT 4 -- ut31 nc-transcript-variantese33Minor allele frequency- T:0.00MN NA 188
    rs1866221101,2
    --156278879(+) CTGCCA/CCCCAA 4 -- nc-transcript-variantut310--------
    rs1144874631,2
    C,F,--156278964(+) TTCTGT/GGCATT 4 -- nc-transcript-variantut311Minor allele frequency- G:0.05WA 118

    HapMap Linkage Disequilibrium report for CCT3 (156278752 - 156337664 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCT3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCT3
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCT3 for disorders           About GeneDecksing

    OMIM gene information: 600114    OMIM disorders: --

    14 diseases for CCT3:    About MalaCards
    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3    nephronopthisis
    fanconi's anemia    huntington's disease    cerebritis    anemia
    hepatocellular carcinoma    schizophrenia    carcinoma    malaria
    pancreatic cancer    pancreatitis

    Human Genome Epidemiology (HuGE) Navigator: CCT3 (1 document)

    Export disorders for CCT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCT3 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with CCT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. (PubMed id 8573069)1, 2, 9 Walkley N.A.... Malik A.N. (1996)
    2. Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization. (PubMed id 8001976)1, 2, 9 Sevigny G.... Lemieux N. (1994)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
    6. cDNA encoding a novel TCP1-related protein. (PubMed id 8110840)1, 3 Joly E.C....Bibor-Hardy V. (1994)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
    10. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7203 HGNC: 1616 AceView: CCT3 Ensembl:ENSG00000163468 euGenes: HUgn7203
    ECgene: CCT3 H-InvDB: CCT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCT3 gene:
    Search GeneIP for patents involving CCT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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