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CCT3 Gene

protein-coding   GIFtS: 67
GCID: GC01M156278

Chaperonin Containing TCP1, Subunit 3 (Gamma)


(Previous symbol: TRIC5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chaperonin Containing TCP1, Subunit 3 (Gamma)1 2     hTRiC52 3
TRIC51 2 3 5     PIG482
CCT-gamma2 3     T-Complex Protein 1 Subunit Gamma2
CCTG2 3     T-Complex Protein 1, Gamma Subunit2
TCP-1-gamma2 3     TCP1 (T-Complex-1) Ring Complex, Polypeptide 52

External Ids:    HGNC: 16161   Entrez Gene: 72032   Ensembl: ENSG000001634687   OMIM: 6001145   UniProtKB: P493683   

Export aliases for CCT3 gene to outside databases

Previous GC identifers: GC01M154147 GC01M152043 GC01M153056 GC01M153495 GC01M153091 GC01M154545 GC01M127638


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCT3 Gene:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1
complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings,
each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are
folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate
transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has
been found on chromosome 8. (provided by RefSeq, Aug 2010)

GeneCards Summary for CCT3 Gene:
CCT3 (chaperonin containing TCP1, subunit 3 (gamma)) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCT3 gene promoter:
         AML1a   Egr-1   Nkx5-1   MEF-2A   CBF-B   CBF-A   ARP-1   aMEF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT3 promoter sequence
   Search Chromatin IP Primers for CCT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q23

CCT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156278:  view genomic region     (about GC identifiers)

Start:
156,278,752 bp from pter      End:
156,337,664 bp from pter
Size:
58,913 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368 (See protein sequence)
Recommended Name: T-complex protein 1 subunit gamma  
Size: 545 amino acids; 60534 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8. Interacts with DYX1C1 (By similarity)
Sequence caution: Sequence=AAH08019.1; Type=Erroneous initiation;
Secondary accessions: A6NE14 Q5SZY1 Q9BR64
Alternative splicing: 2 isoforms:  P49368-1   P49368-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT3: NX_P49368

Explore proteomics data for CCT3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21, Lys31, Lys44, Lys48, Lys78, Lys248, Lys249, Lys354, Lys381, Lys427,
                                 Lys502, Lys507
  • Modification sites at PhosphoSitePlus

  • See CCT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008800.1  NP_005989.3  

    ENSEMBL proteins: 
     ENSP00000295688   ENSP00000357242   ENSP00000357241   ENSP00000357245   ENSP00000431543  
     ENSP00000413308   ENSP00000434232   ENSP00000434481   ENSP00000388799   ENSP00000435026  
     ENSP00000413431   ENSP00000357244  
    Reactome Protein details: P49368

    CCT3 Human Recombinant Protein Products:

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    OriGene MassSpec for CCT3
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    Novus Biologicals CCT3 Protein
    Novus Biologicals CCT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT3

     
    Search eBioscience for Proteins for CCT3 

    CCT3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies for CCT3
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    Novus Biologicals CCT3 Antibodies
    Abcam antibodies for CCT3
    Cloud-Clone Corp. Antibodies for CCT3
    ThermoFisher Antibodies for CCT3
    LSBio Antibodies in human, mouse, rat for CCT3

    CCT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCT3
    Cloud-Clone Corp. CLIAs for CCT3
    Search eBioscience for ELISAs for CCT3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHAP: Heat Shock Proteins / Chaperonins

    Selected InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR012719 Chap_CCT_gamma
     IPR002194 Chaperonin_TCP-1_CS
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom

    Graphical View of Domain Structure for InterPro Entry P49368

    ProtoNet protein and cluster: P49368

    2 Blocks protein domains:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368
    Similarity: Belongs to the TCP-1 chaperonin family


    Find genes that share domains with CCT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPG_HUMAN, P49368
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
    may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
    the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

         Genatlas biochemistry entry for CCT3:
    chaperonin containing TCP1 (T complex protein 1) subunit 3 (gamma),cytosolic,widely expressed in fetal and adult
    tissues,TF55/TCP-1 family

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12620389
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with CCT3           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for CCT3:
     Cell division defect  Increased G2M DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCT3:
    hsa-mir-124-3p (MIRT022720), hsa-mir-103a-3p (MIRT027135), hsa-mir-1301-3p (MIRT035989), hsa-mir-34a-5p (MIRT047351), hsa-mir-320a (MIRT044775), hsa-mir-16-5p (MIRT031786), hsa-mir-151a-5p (MIRT019519), hsa-mir-221-3p (MIRT046847), hsa-mir-320b (MIRT036217), hsa-mir-183-5p (MIRT025020), hsa-mir-330-5p (MIRT038250)

    Block miRNA regulation of human, mouse, rat CCT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCT3 (see all 10):
    hsa-miR-3688-3p hsa-miR-522 hsa-miR-324-3p hsa-miR-224* hsa-miR-105 hsa-miR-223 hsa-miR-338-5p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCCT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCT3
    Predesigned siRNA for gene silencing in human, mouse, rat CCT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCT3

    Clone
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    OriGene clones in human, mouse for CCT3 (see all 16)
    OriGene ORF clones in mouse, rat for CCT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCT3 (NM_005998)
    Sino Biological Human cDNA Clone for CCT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CCT3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCT3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCPG_HUMAN, P49368: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    plasma membrane4
    mitochondrion2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--
    GO:0005856cytoskeleton TAS8001976

    Find genes that share ontologies with CCT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCT3 About    
    See pathways by source

    SuperPathContained pathways About
    1Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76
    Folding of actin by CCT/TriC0.00
    2Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation


    Find genes that share SuperPaths with CCT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CCT3
        Cell cycle Role of APC in cell cycle regulation


    4 Reactome Pathways for CCT3
        Association of TriC/CCT with target proteins during biosynthesis
    Formation of tubulin folding intermediates by CCT/TriC
    Prefoldin mediated transfer of substrate to CCT/TriC
    Folding of actin by CCT/TriC


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT3: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCT3 (P493681, 2, 3 ENSP000003572444) via UniProtKB, MINT, STRING, and/or I2D (see all 1190)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAF1P040491, 2, 3, ENSP000002518494EBI-356673,EBI-365996 MINT-19325 I2D: score=5 STRING: ENSP00000251849
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=4 STRING: ENSP00000317334
    CCT2P783712, 3, ENSP000002993004MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=3 STRING: ENSP00000299300
    CCT7Q998322, 3, ENSP000002580914MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=1 STRING: ENSP00000258091
    ENSG00000258947Q135092, 3, ENSP000003202954MINT-7945693 MINT-8415355 I2D: score=1 STRING: ENSP00000320295
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    Find genes that share ontologies with CCT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCT3 (TCPG)

    2 DrugBank Compounds for CCT3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCT3 gene (3 alternative transcripts): 
    NM_001008800.2  NM_005998.4  NM_001008883.1  

    Unigene Cluster for CCT3:

    Chaperonin containing TCP1, subunit 3 (gamma)
    Hs.491494  [show with all ESTs]
    Unigene Representative Sequence: NR_036564
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295688(uc010phj.2 uc010phk.2 uc001fol.2 uc001fon.2 uc010phl.2)
    ENST00000368259 ENST00000368258 ENST00000368262 ENST00000472765 ENST00000413555
    ENST00000496684 ENST00000533194 ENST00000463132 ENST00000490221 ENST00000446905
    ENST00000478640 ENST00000415548 ENST00000368256 ENST00000489870 ENST00000368261

    miRNA
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    Block miRNA regulation of human, mouse, rat CCT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCT3 (see all 10):
    hsa-miR-3688-3p hsa-miR-522 hsa-miR-324-3p hsa-miR-224* hsa-miR-105 hsa-miR-223 hsa-miR-338-5p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCCT3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCT3
    Clone
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    OriGene clones in human, mouse for CCT3 (see all 16)
    OriGene ORF clones in mouse, rat for CCT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCT3 (NM_005998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCT3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT3
      QuantiTect SYBR Green Assays in human, mouse, rat CCT3
      QuantiFast Probe-based Assays in human, mouse, rat CCT3

    Additional mRNA sequence: 

    AB208882.1 AK126400.1 AK293477.1 AK300765.1 AK308023.1 AK315923.1 AK316387.1 AL833197.1 
    AY524046.1 BC006501.2 BC008019.1 NR_036564.1 NR_036565.1 U17104.1 X74801.1 

    Selected DOTS entries (see all 61):

    DT.97861030  DT.92053803  DT.92472159  DT.100045579  DT.100689696  DT.95351547  DT.95351599  DT.121427176 
    DT.100874374  DT.100689675  DT.100689683  DT.121427005  DT.100689688  DT.100689702  DT.92472168  DT.92472182 
    DT.121427032  DT.121427179  DT.121427060  DT.121426945  DT.121426934  DT.95143909  DT.97861032  DT.100689691 

    Selected AceView cDNA sequences (see all 2308):

    BQ050780 BG490954 BU501733 BQ056438 BG252556 BI090224 BQ069266 AU120983 
    BE256283 AI439219 BM985181 BU509136 BU618841 BE791876 AA454885 BM769016 
    BQ286127 BQ063493 BQ643118 BQ057668 R52111 BQ060875 BI223407 BM564689 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCT3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                                                        
    SP2:                                      -     -                                                                           
    SP3:                                                                                -                                       


    ECgene alternative splicing isoforms for CCT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTCTTCT
    CCT3 Expression
    About this image


    CCT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    CCT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491494
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT3: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCT3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT3
    QuantiTect SYBR Green Assays in human, mouse, rat CCT3
    QuantiFast Probe-based Assays in human, mouse, rat CCT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT3 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct31 , 5 chaperonin containing Tcp1, subunit 3 (gamma)1, 5 89.72(n)1
    97.25(a)1
      3 (38.79 cM)5
    124621  NM_009836.11  NP_033966.11 
     882971165 
    chicken
    (Gallus gallus)
    Aves CCT31 chaperonin containing TCP1, subunit 3 (gamma) 75.51(n)
    85.19(a)
      425644  XM_423379.4  XP_423379.4 
    lizard
    (Anolis carolinensis)
    Reptilia CCT36
    chaperonin containing TCP1, subunit 3 (gamma)
    88(a)
    1 ↔ 1
    AAWZ02036469(10145-26448)
    African clawed frog
    (Xenopus laevis)
    Amphibia cct3-prov2 chaperonin containing TCP-1 complex gamma chain 79.31(n)    BC048365.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cct32 chaperonin containing TCP1, subunit 3 (gamma) 77.37(n)   192327  BC053271.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cctgamma1 , 3 protein folding chaperonin ATPase3
    Cctgamma1
    68(a)3
    67.6(n)1
    70.39(a)1
      3 89D63
    420291  NM_142315.41  NP_650572.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F54A3.33
    cct-31
    cct-31 50(a)3
    60.56(n)1
    62.6(a)1
      II(2233549-2242578)3
    1735811  NM_061817.51  NP_494218.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT3(YJL014W)4
    CCT31
    Subunit of the cytosolic chaperonin Cct ring complex, more4
    CCT31
    58.89(n)1
    60.61(a)1
      10(407558-409162)4
    8534381, 4  NP_012520.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G263601 AT5G26360 60.27(n)
    61.79(a)
      832705  NM_122537.3  NP_198008.1 
    rice
    (Oryza sativa)
    Liliopsida Os.122042 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.64(n)    AK069949.1 


    ENSEMBL Gene Tree for CCT3 (if available)
    TreeFam Gene Tree for CCT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCT3 gene
    Selected SIMAP similar genes for CCT3 using alignment to 10 protein entries:     TCPG_HUMAN (see all proteins) (see all similar genes):
    DNAPTP3    KIAA1651    LRRC37A3    OK/SW-cl.41    PODXL    TMEM135
    ZNF195    FAM138C    PLA2G15    ZNF843    APCDD1    ZNF573
    BCKDHA    AHSA1    PPP2R1A    TCP1    CCT4    CCT7

    Find genes that share paralogs with CCT3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCT3
    PGOHUM00000249580


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCT3 (see all 606)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390236811,2
    --156278264(+) AGAGGC/TCTGAC 4 -- ds50010--------
    rs1120824321,2
    C--156278392(+) ACACC-/A/AA  
            
    AAAAA
    4 -- ds50011CSA 2
    rs67004171,2
    C--156278419(+) TGTCCA/TTTAGG 4 -- ds50010--------
    rs1918870851,2
    C--156278473(+) ACAACC/TACATA 4 -- ds50010--------
    rs1444570631,2
    C--156278537(+) CAAAAC/TGGTGC 4 -- ds50010--------
    rs1484250491,2
    C--156278599(+) CAAAAC/TTTACT 4 -- ds50010--------
    rs1815677131,2
    --156278747(+) AACACA/GTAACA 4 -- ds50010--------
    rs1155324191,2
    C,F--156278754(+) AACAAC/TTTTCT 4 -- nc-transcript-variantut311Minor allele frequency- T:0.03WA 118
    rs80351,2
    C,F--156278799(-) GGTTTC/TCATTT 4 -- nc-transcript-variantut31 ese33Minor allele frequency- T:0.00MN NA 188
    rs1866221101,2
    --156278879(+) CTGCCA/CCCCAA 4 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for CCT3 (156278752 - 156337664 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1449360CNV Insertion17803354
    nsv872471CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCT3
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600114    OMIM disorders: --


    Find genes that share disorders with CCT3           About GenesLikeMe

    Genetic Association Database (GAD): CCT3
    Human Genome Epidemiology (HuGE) Navigator: CCT3 (1 document)

    Export disorders for CCT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCT3 gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with CCT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. (PubMed id 8573069)1, 2, 9 Walkley N.A.... Malik A.N. (Biochem. J. 1996)
    2. Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization. (PubMed id 8001976)1, 2, 9 Sevigny G.... Lemieux N. (Genomics 1994)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)
    7. cDNA encoding a novel TCP1-related protein. (PubMed id 8110840)1, 3 Joly E.C....Bibor-Hardy V. (Biochim. Biophys. Acta 1994)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7203 HGNC: 1616 AceView: CCT3 Ensembl:ENSG00000163468 euGenes: HUgn7203
    ECgene: CCT3 H-InvDB: CCT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCT3 gene:
    Search GeneIP for patents involving CCT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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