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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCT3 Gene

protein-coding   GIFtS: 65
GCID: GC01M156278

Chaperonin Containing TCP1, Subunit 3 (Gamma)


(Previous symbol: TRIC5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chaperonin Containing TCP1, Subunit 3 (Gamma)1 2     hTRiC52 3
TRIC51 2 3 5     PIG482
CCT-gamma2 3     T-Complex Protein 1 Subunit Gamma2
CCTG2 3     T-Complex Protein 1, Gamma Subunit2
TCP-1-gamma2 3     TCP1 (T-Complex-1) Ring Complex, Polypeptide 52

External Ids:    HGNC: 16161   Entrez Gene: 72032   Ensembl: ENSG000001634687   OMIM: 6001145   UniProtKB: P493683   

Export aliases for CCT3 gene to outside databases

Previous GC identifers: GC01M154147 GC01M152043 GC01M153056 GC01M153495 GC01M153091 GC01M154545 GC01M127638


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCT3 Gene:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1
complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings,
each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are
folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate
transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has
been found on chromosome 8. (provided by RefSeq, Aug 2010)

GeneCards Summary for CCT3 Gene: 
CCT3 (chaperonin containing TCP1, subunit 3 (gamma)) is a protein-coding gene. Diseases associated with CCT3 include cerebral cavernous malformations 3, and cavernous malformation, and among its related super-pathways are Formation of tubulin folding intermediates by CCT/TriC and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and ATP binding.

UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCT3 gene promoter:
         AML1a   Egr-1   Nkx5-1   MEF-2A   CBF-B   CBF-A   ARP-1   aMEF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q23

CCT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156278:  view genomic region     (about GC identifiers)

Start:
156,278,752 bp from pter      End:
156,337,664 bp from pter
Size:
58,913 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368 (See protein sequence)
Recommended Name: T-complex protein 1 subunit gamma  
Size: 545 amino acids; 60534 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAH08019.1; Type=Erroneous initiation;
Secondary accessions: A6NE14 Q5SZY1 Q9BR64
Alternative splicing: 2 isoforms:  P49368-1   P49368-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT3: NX_P49368

Explore proteomics data for CCT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49368

  • CCT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCT3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001008800.1  NP_005989.3  

    ENSEMBL proteins: 
     ENSP00000295688   ENSP00000357242   ENSP00000357241   ENSP00000357245   ENSP00000431543  
     ENSP00000413308   ENSP00000434232   ENSP00000434481   ENSP00000388799   ENSP00000435026  
     ENSP00000413431   ENSP00000357244  
    Reactome Protein details: P49368
    Human Recombinant Protein Products for CCT3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for CCT3
    OriGene MassSpec for CCT3 
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    Novus Biologicals CCT3 Protein
    Novus Biologicals CCT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT3 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--
    GO:0005856cytoskeleton TAS8001976

    CCT3 for ontologies           About GeneDecksing



    CCT3 Antibody Products: 
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    Novus Biologicals CCT3 Antibodies
    Abcam antibodies for CCT3
    Cloud-Clone Corp. Antibodies for CCT3 
    ThermoFisher Antibodies for CCT3
    LSBio Antibodies in human, mouse, rat for CCT3 

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    Cloud-Clone Corp. ELISAs for CCT3 
    Cloud-Clone Corp. CLIAs for CCT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHAP: Heat Shock Proteins / Chaperonins

    5/7 InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR012719 Chap_CCT_gamma
     IPR002194 Chaperonin_TCP-1_CS
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom

    Graphical View of Domain Structure for InterPro Entry P49368

    ProtoNet protein and cluster: P49368

    2 Blocks protein domains:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPG_HUMAN, P49368
    Similarity: Belongs to the TCP-1 chaperonin family


    CCT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPG_HUMAN, P49368
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
    may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
    the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

         Genatlas biochemistry entry for CCT3:
    chaperonin containing TCP1 (T complex protein 1) subunit 3 (gamma),cytosolic,widely expressed in fetal and adult
    tissues,TF55/TCP-1 family

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12620389
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    CCT3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CCT3:
     Cell division defect  Increased G2M DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT3 

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CCT3 (see all 10):
    hsa-miR-3688-3p hsa-miR-522 hsa-miR-324-3p hsa-miR-224* hsa-miR-105 hsa-miR-223 hsa-miR-338-5p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCCT3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CCT3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCT3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Formation of tubulin folding intermediates by CCT/TriC
    Formation of tubulin folding intermediates by CCT/TriC0.74
    Prefoldin mediated transfer of substrate to CCT/TriC0.70
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.74
    Folding of actin by CCT/TriC0.38
    2Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    3Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation0.98
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCT3
        Cell cycle Role of APC in cell cycle regulation


    1 GeneGo (Thomson Reuters) Pathway for CCT3
        Cell cycle Role of APC in cell cycle regulation

    5/8        Reactome Pathways for CCT3 (see all 8)
        Formation of tubulin folding intermediates by CCT/TriC
    Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Prefoldin mediated transfer of substrate to CCT/TriC
    Metabolism of proteins



    CCT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1051 Interacting proteins for CCT3 (P493681, 2, 3 ENSP000003572444) via UniProtKB, MINT, STRING, and/or I2D (see all 1051)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=4 STRING: ENSP00000317334
    CCT4P509912, 3, ENSP000003779584MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=2 STRING: ENSP00000377958
    CCT7Q998322, 3, ENSP000002580914MINT-7945693 MINT-8415355 MINT-7947479 I2D: score=1 STRING: ENSP00000258091
    ENSG00000258947Q135092, 3MINT-7945693 MINT-8415355 I2D: score=1 
    SF3B1O755332, 3, ENSP000003353214MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000335321
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    CCT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCT3 (TCPG)

    2 DrugBank Compounds for CCT3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about CCT3 / TCPG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCT3 gene (3 alternative transcripts): 
    NM_001008800.2  NM_005998.4  NM_001008883.1  

    Unigene Cluster for CCT3:

    Chaperonin containing TCP1, subunit 3 (gamma)
    Hs.491494  [show with all ESTs]
    Unigene Representative Sequence: NR_036564
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295688(uc010phj.2 uc010phk.2 uc001fol.2 uc001fon.2 uc010phl.2)
    ENST00000368259 ENST00000368258 ENST00000480049 ENST00000368262 ENST00000472765
    ENST00000413555 ENST00000496684 ENST00000533194 ENST00000463132 ENST00000490221
    ENST00000446905 ENST00000478640 ENST00000415548 ENST00000368256 ENST00000489870
    ENST00000368261
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CCT3 (see all 10):
    hsa-miR-3688-3p hsa-miR-522 hsa-miR-324-3p hsa-miR-224* hsa-miR-105 hsa-miR-223 hsa-miR-338-5p hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCCT3 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT3
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    Primer
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    Additional mRNA sequence: 

    AB208882.1 AK126400.1 AK293477.1 AK300765.1 AK308023.1 AK315923.1 AK316387.1 AL833197.1 
    AY524046.1 BC006501.2 BC008019.1 NR_036564.1 NR_036565.1 U17104.1 X74801.1 

    24/61 DOTS entries (see all 61):

    DT.97861030  DT.92053803  DT.92472159  DT.100045579  DT.100689696  DT.95351547  DT.95351599  DT.121427176 
    DT.100874374  DT.100689675  DT.100689683  DT.121427005  DT.100689688  DT.100689702  DT.92472168  DT.92472182 
    DT.121427032  DT.121427179  DT.121427060  DT.121426945  DT.121426934  DT.95143909  DT.97861032  DT.100689691 

    24/2308 AceView cDNA sequences (see all 2308):

    BU618841 BM826538 BU192268 BQ071326 BQ065369 BE464536 BQ066683 CA443562 
    BQ063122 BM787394 BI225402 BQ957312 BG470637 BM694676 CR592621 AU125346 
    BU152940 BE256283 BQ935796 AU121936 BM016269 BQ642997 AU142903 BQ063226 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCT3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                                                        
    SP2:                                      -     -                                                                           
    SP3:                                                                                -                                       


    ECgene alternative splicing isoforms for CCT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCT3 expression in normal human tissues (normalized intensities)      CCT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTCTTCT
    CCT3 Expression
    About this image


    CCT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Lymph (Hematopoietic System)

    See CCT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCT3

    SOURCE GeneReport for Unigene cluster: Hs.491494
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCT3: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT3 gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct31 , 5 chaperonin containing Tcp1, subunit 3 (gamma)1, 5 89.72(n)1
    97.25(a)1
      3 (38.79 cM)5
    124621  NM_009836.11  NP_033966.11 
     882971165 
    chicken
    (Gallus gallus)
    Aves --
    --
    --
    85(a)
    57(a)
    many → 1
    many → 1
    AADN03024078.1(21-2135)
    AADN03026458.1(21-988)
    lizard
    (Anolis carolinensis)
    Reptilia CCT36
    Uncharacterized protein
    88(a)
    1 ↔ 1
    AAWZ02036469(10145-26448)
    African clawed frog
    (Xenopus laevis)
    Amphibia cct3-prov2 chaperonin containing TCP-1 complex gamma chain 79.31(n)    BC048365.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cct32 chaperonin containing TCP1, subunit 3 (gamma) 77.37(n)   192327  BC053271.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cct&ggr;3
    Cctgamma1
    protein folding chaperonin ATPase3
    CCTgamma-like1
    68(a)3
    67.66(n)1
    70.39(a)1
      3 89D63
    420291  NM_001202307.11  NP_001189236.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F54A3.33
    cct-31
    Protein CCT-31 50(a)3
    60.56(n)1
    62.6(a)1
      II(2233549-2242578)3
    1735811  NM_061817.41  NP_494218.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT3(YJL014W)4
    CCT31
    Subunit of the cytosolic chaperonin Cct ring complex, more4
    Cct3p1
    58.89(n)1
    60.61(a)1
      10(407558-409162)4
    8534381, 4  NP_012520.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G263601 TCP-1/cpn60 chaperonin family protein 60.27(n)
    61.79(a)
      832705  NM_122537.3  NP_198008.1 
    rice
    (Oryza sativa)
    Liliopsida Os.122042 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.64(n)    AK069949.1 


    ENSEMBL Gene Tree for CCT3 (if available)
    TreeFam Gene Tree for CCT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCT3 gene
    18/27 SIMAP similar genes for CCT3 using alignment to 10 protein entries:     TCPG_HUMAN (see all proteins) (see all similar genes):
    DNAPTP3    KIAA1651    LRRC37A3    OK/SW-cl.41    PODXL    TMEM135
    ZNF195    FAM138A    FAM138B    FAM138C    FAM138F    PLA2G15
    ZNF843    FAM138D    APCDD1    ZNF573    BCKDHA    AHSA1

    CCT3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCT3
    PGOHUM00000249580


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/606 SNPs in CCT3 are shown (see all 606)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390236811,2
    --156278264(+) AGAGGC/TCTGAC 4 -- ds50010--------
    rs1120824321,2
    C--156278392(+) ACACC-/A/AA  
            
    AAAAA
    4 -- ds50011CSA 2
    rs67004171,2
    C--156278419(+) TGTCCA/TTTAGG 4 -- ds50010--------
    rs1918870851,2
    C--156278473(+) ACAACC/TACATA 4 -- ds50010--------
    rs1444570631,2
    C--156278537(+) CAAAAC/TGGTGC 4 -- ds50010--------
    rs1484250491,2
    C--156278599(+) CAAAAC/TTTACT 4 -- ds50010--------
    rs1815677131,2
    --156278747(+) AACACA/GTAACA 4 -- ds50010--------
    rs1155324191,2
    C,F--156278754(+) AACAAC/TTTTCT 4 -- nc-transcript-variantut311Minor allele frequency- T:0.03WA 118
    rs80351,2
    C,F--156278799(-) GGTTTC/TCATTT 4 -- nc-transcript-variantut31 ese33Minor allele frequency- T:0.00MN NA 188
    rs1866221101,2
    --156278879(+) CTGCCA/CCCCAA 4 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for CCT3 (156278752 - 156337664 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1449360CNV Insertion17803354
    nsv872471CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600114    OMIM disorders: --

    10 diseases for CCT3:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    cerebritis
    fanconi's anemia    anemia    pancreatic cancer    schizophrenia
    pancreatitis    hepatocellular carcinoma


    CCT3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCT3
    Human Genome Epidemiology (HuGE) Navigator: CCT3 (1 document)

    Export disorders for CCT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCT3 gene, integrated from 9 sources (see all 91):
    (articles sorted by number of sources associating them with CCT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma. (PubMed id 8573069)1, 2, 9 Walkley N.A.... Malik A.N. (1996)
    2. Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization. (PubMed id 8001976)1, 2, 9 Sevigny G.... Lemieux N. (1994)
    3. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
    7. cDNA encoding a novel TCP1-related protein. (PubMed id 8110840)1, 3 Joly E.C....Bibor-Hardy V. (1994)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    9. The novel ubiquitin ligase complex, SCF(Fbxw4), intera cts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (2013)
    10. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7203 HGNC: 1616 AceView: CCT3 Ensembl:ENSG00000163468 euGenes: HUgn7203
    ECgene: CCT3 H-InvDB: CCT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCT3 gene:
    Search GeneIP for patents involving CCT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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