Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CCT2 Gene

protein-coding   GIFtS: 66
GCID: GC12P069979

Chaperonin Containing TCP1, Subunit 2 (Beta)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chaperonin Containing TCP1, Subunit 2 (Beta)1 2     PRO16332
CCTB2 3 5     Chaperonin Containing T-Complex Polypeptide 1, Beta Subunit2
99D8.12 3     Chaperonin Containing T-Complex Polypeptide 1, Subunit 22
CCT-beta2 3     Epididymis Secretory Sperm Binding Protein Li 100n2
TCP-1-beta2 3     T-Complex Protein 1 Subunit Beta2
HEL-S-100n2     T-Complex Protein 1, Beta Subunit2

External Ids:    HGNC: 16151   Entrez Gene: 105762   Ensembl: ENSG000001662267   OMIM: 6051395   UniProtKB: P783713   

Export aliases for CCT2 gene to outside databases

Previous GC identifers: GC12P069837 GC12P069695 GC12P068265 GC12P067028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CCT2 Gene:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1
complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings,
each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are
folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for CCT2 Gene:
CCT2 (chaperonin containing TCP1, subunit 2 (beta)) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: TCPB_HUMAN, P78371
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCT2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   Nkx2-5   POU3F2   LCR-F1   GATA-2   Nkx3-1 v2   FOXO4   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT2 promoter sequence
   Search Chromatin IP Primers for CCT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q14

CCT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P069979:  view genomic region     (about GC identifiers)

Start:
69,979,114 bp from pter      End:
69,995,357 bp from pter
Size:
16,244 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TCPB_HUMAN, P78371 (See protein sequence)
Recommended Name: T-complex protein 1 subunit beta  
Size: 535 amino acids; 57488 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8
Secondary accessions: A8K402 B5BTY7 B7Z243 B7Z7K4 B7ZAT2 Q14D36 Q6IAT3
Alternative splicing: 2 isoforms:  P78371-1   P78371-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT2: NX_P78371

Explore proteomics data for CCT2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13, Lys40, Lys46, Lys72, Lys82, Lys120, Lys154, Lys191, Lys204, Lys236,
                                 Lys248, Lys250, Lys284, Lys342, Lys402, Lys441, Lys522
  • Modification sites at PhosphoSitePlus

  • See CCT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001185771.1  NP_006422.1  

    ENSEMBL proteins: 
     ENSP00000299300   ENSP00000441847   ENSP00000450153   ENSP00000445471  
    Reactome Protein details: P78371

    CCT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCT2
    OriGene Protein Over-expression Lysate for CCT2
    OriGene MassSpec for CCT2
    OriGene Custom Protein Services for CCT2
    GenScript Custom Purified and Recombinant Proteins Services for CCT2
    Novus Biologicals CCT2 Proteins
    Novus Biologicals CCT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT2

     
    Search eBioscience for Proteins for CCT2 

    CCT2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCT2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CCT2 
    OriGene Antibodies for CCT2
    OriGene Custom Antibody Services for CCT2
    Novus Biologicals CCT2 Antibodies
    Abcam antibodies for CCT2
    Cloud-Clone Corp. Antibodies for CCT2
    ThermoFisher Antibody for CCT2
    LSBio Antibodies in human, mouse, rat for CCT2

    CCT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCT2
    Cloud-Clone Corp. CLIAs for CCT2
    Search eBioscience for ELISAs for CCT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CHAP: Heat Shock Proteins / Chaperonins

    Selected InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR012716 Chap_CCT_beta
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom

    Graphical View of Domain Structure for InterPro Entry P78371

    ProtoNet protein and cluster: P78371

    2 Blocks protein domains:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPB_HUMAN, P78371
    Similarity: Belongs to the TCP-1 chaperonin family


    Find genes that share domains with CCT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPB_HUMAN, P78371
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
    may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
    the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

         Genatlas biochemistry entry for CCT2:
    chaperonin containing TCP1,subunit 2 (beta),cytosolic,TF55/TCP-1 family

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding NAS11532003
         
    Find genes that share ontologies with CCT2           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for CCT2:
     Cell division defect  Decreased CYP1A1 activity afte  Decreased viability of wild-ty  Increased G2M DNA content 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce  Prevent p53-dependent growth a  Synthetic lethal with Ras 
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCT2:
    hsa-mir-155-5p (MIRT021019), hsa-mir-193b-3p (MIRT041339)

    Block miRNA regulation of human, mouse, rat CCT2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCT2:
    hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCT2
    Predesigned siRNA for gene silencing in human, mouse, rat CCT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCT2

    Clone
    Products:
         
    OriGene clones in human, mouse for CCT2 (see all 9)
    OriGene ORF clones in mouse, rat for CCT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCT2 (NM_006431)
    Sino Biological Human cDNA Clone for CCT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TCPB_HUMAN, P78371: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    nucleus4
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005832chaperonin-containing T-complex IEA--

    Find genes that share ontologies with CCT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CCT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76
    Folding of actin by CCT/TriC0.00
    2Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation


    Find genes that share SuperPaths with CCT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CCT2
        Cell cycle Role of APC in cell cycle regulation


    4 Reactome Pathways for CCT2
        Association of TriC/CCT with target proteins during biosynthesis
    Formation of tubulin folding intermediates by CCT/TriC
    Prefoldin mediated transfer of substrate to CCT/TriC
    Folding of actin by CCT/TriC


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT2: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCT2 (P783711, 2, 3 ENSP000002993004) via UniProtKB, MINT, STRING, and/or I2D (see all 1186)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--
    GO:0051131chaperone-mediated protein complex assembly IMP--

    Find genes that share ontologies with CCT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCT2 (TCPB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CCT2 gene (2 alternative transcripts): 
    NM_001198842.1  NM_006431.2  

    Unigene Cluster for CCT2:

    Chaperonin containing TCP1, subunit 2 (beta)
    Hs.189772  [show with all ESTs]
    Unigene Representative Sequence: NM_001198842
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299300(uc001svb.1) ENST00000546859 ENST00000549933 ENST00000550455
    ENST00000550638 ENST00000551620 ENST00000551899 ENST00000544368 ENST00000550010
    ENST00000543146(uc010stl.1) ENST00000548787 ENST00000546850 ENST00000553169
    ENST00000550653
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCT2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCT2:
    hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCT2
    Predesigned siRNA for gene silencing in human, mouse, rat CCT2
    Clone
    Products:
         
    OriGene clones in human, mouse for CCT2 (see all 9)
    OriGene ORF clones in mouse, rat for CCT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCT2 (NM_006431)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT2
      QuantiTect SYBR Green Assays in human, mouse, rat CCT2
      QuantiFast Probe-based Assays in human, mouse, rat CCT2

    Additional mRNA sequence: 

    AB451223.1 AB451346.1 AF026166.1 AF026293.1 AK290767.1 AK294307.1 AK297685.1 AK302157.1 
    AK316397.1 AK316408.1 BC113514.1 BC113516.1 BT019966.1 CR457071.1 

    Selected DOTS entries (see all 27):

    DT.95366739  DT.95228517  DT.95366744  DT.100848412  DT.100848417  DT.95334620  DT.100848410  DT.100848405 
    DT.121194487  DT.121194472  DT.100848402  DT.121194449  DT.40225073  DT.40240828  DT.92459856  DT.95071193 
    DT.95366729  DT.95366749  DT.100731827  DT.100773145  DT.100848404  DT.121194503  DT.91652122  DT.95366737 

    Selected AceView cDNA sequences (see all 826):

    BU860151 AW001935 CA866395 BE893297 AU133858 AL121077 BU849358 BM918475 
    AA598835 BF797374 AU128577 AU279482 BM999485 T36024 BP336785 CA416238 
    BQ214339 CK821678 CR615034 CF146990 BQ573845 BQ229302 BM764593 BQ778141 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCT2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:              -     -                 -     -           -           -           -           -                                                               
    SP2:              -     -                 -     -           -           -           -                                                                           
    SP3:                                      -     -           -           -           -                                                                           
    SP4:              -     -                 -     -           -           -                                                                                       
    SP5:                                                                    -           -           -                 -                                             


    ECgene alternative splicing isoforms for CCT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CCT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGACACA
    CCT2 Expression
    About this image


    CCT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CCT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.189772
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCT2: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CCT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT2
    QuantiTect SYBR Green Assays in human, mouse, rat CCT2
    QuantiFast Probe-based Assays in human, mouse, rat CCT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT2 gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct21 , 5 chaperonin containing Tcp1, subunit 2 (beta)1, 5 89.1(n)1
    97.57(a)1
      10 (65.07 cM)5
    124611  NM_007636.21  NP_031662.21 
     1170509985 
    chicken
    (Gallus gallus)
    Aves CCT21 chaperonin containing TCP1, subunit 2 (beta) 81.81(n)
    93.08(a)
      417846  NM_001012533.2  NP_001012551.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCT26
    chaperonin containing TCP1, subunit 2 (beta)
    89(a)
    1 ↔ 1
    GL343256.1(1643840-1653857)
    African clawed frog
    (Xenopus laevis)
    Amphibia cct2-prov2 chaperonin subunit 2 (beta) 78.98(n)    BC042347.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cct22 chaperonin containing TCP1, subunit 2 (beta) 74.36(n)   192326  BC059558.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70331 , 3 chaperone3
    CG70331
    71(a)3
    62.78(n)1
    71.43(a)1
      8C83
    318381  NM_132296.31  NP_572524.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cct-21 cct-2 61.92(n)
    66.98(a)
      174421  NM_171985.5  NP_741031.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT2(YIL142W)4
    CCT21
    Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo less4
    CCT21
    61.89(n)1
    66.16(a)1
      9(83302-84885)4
    8546641, 4  NP_012124.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G208901 AT5G20890 64.81(n)
    68.14(a)
      832213  NM_122097.2  NP_197589.1 
    rice
    (Oryza sativa)
    Liliopsida Os.83832 Oryza sativa (japonica cultivar-group) cDNA clone001-031-E04, full insert sequence less 75.95(n)    AK059663.1 


    ENSEMBL Gene Tree for CCT2 (if available)
    TreeFam Gene Tree for CCT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CCT2 gene
    8 SIMAP similar genes for CCT2 using alignment to 3 protein entries:     TCPB_HUMAN (see all proteins):
    CCT5    TCP1    CCT3    CCT7    CCT4    CCT6B
    CCT6A    CCT8

    Find genes that share paralogs with CCT2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCT2
    PGOHUM00000261534


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CCT2 (see all 391)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021861721,2
    C,F--69980614(+) TAGAAA/GAGTTT 2 -- int11Minor allele frequency- G:0.00EU 819
    rs1440561261,2
    C--69980645(+) GAGCGC/TTTGGT 2 -- int10--------
    rs1403940161,2
    C--69980705(+) TTAAT-/TATAAAA 2 -- int10--------
    rs1473015191,2
    --69980780(+) CCTCCC/GCAATG 2 -- int10--------
    rs768176751,2
    F--69980808(+) TTGCAC/TGTACA 2 -- int11Minor allele frequency- T:0.01EA 120
    rs1488143671,2
    C--69980895(+) AAAAC-/AGATACT 2 -- int10--------
    rs1487577111,2
    --69980946(+) CTTTCA/GGTGTA 2 -- int10--------
    rs2016244571,2
    C--69981030(-) ACTATA/CAATAC 2 -- int10--------
    rs111777321,2
    C,F,H--69981111(+) TAGGGG/ATAGAT 2 -- int110Minor allele frequency- A:0.18NS EA NA CSA WA 776
    rs1997867131,2
    C--69981128(+) TTTGG-/TTACGTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CCT2 (69979114 - 69995357 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCT2: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CCT2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605139    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CCT2:
    Cecum cancer

    Find genes that share disorders with CCT2           About GenesLikeMe

    1 Novoseek inferred disease relationship for CCT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 28 1 11795471 (1)

    Genetic Association Database (GAD): CCT2
    Human Genome Epidemiology (HuGE) Navigator: CCT2 (2 documents)

    Export disorders for CCT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CCT2 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with CCT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PubMed id 9819444)1, 2, 3 Won K.-A.... Reed S.I. (Mol. Cell. Biol. 1998)
    2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    4. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    8. Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin. (PubMed id 10748209)1, 9 Hynes G.M. and Willison K.R. (J. Biol. Chem. 2000)
    9. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    10. The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10576 HGNC: 1615 AceView: CCT2 Ensembl:ENSG00000166226 euGenes: HUgn10576
    ECgene: CCT2 H-InvDB: CCT2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CCT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CCT2 gene:
    Search GeneIP for patents involving CCT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CCT2
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CCT2   OriGene RNAi products in human, mouse, rat for CCT2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CCT2  
     OriGene MassSpec something-or-other for CCT2   OriGene clones in human, mouse for CCT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCT2   OriGene Purified Protein for CCT2  
     OriGene ORF clones in mouse, rat for CCT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCT2   OriGene Custom Protein Services for CCT2  

     
     
     Block miRNA regulation of human, mouse, rat CCT2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCT2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCT2 Predesigned siRNA for gene silencing in human, mouse, rat CCT2
     QuantiFast Probe-based Assays in human, mouse, rat CCT2 QuantiTect SYBR Green Assays in human, mouse, rat CCT2
     PCR Arrays including human, mouse, rat CCT2 Search Chromatin IP Primers for CCT2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCT2  GeneGlobe Interaction Network for CCT2
     Regulatory tfbs in CCT2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CCT2 GenScript cDNA clones with any tag delivered in your preferred vector for CCT2
     GenScript Custom Assay Services for CCT2 GenScript Custom overexpressing Cell Line Services for CCT2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CCT2 

     Search Tocris compounds for CCT2 (TCPB)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CCT2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CCT2 antibodies
     CCT2 proteins
     CCT2 lysates
     Antibodies for CCT2
     See all of Abcam's Antibodies, Kits and Proteins for CCT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CCT2
     Antibodies for CCT2
     ELISAs for CCT2
     CLIAs for CCT2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CCT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT2
     SwitchGear 3'UTR luciferase reporter plasmids for CCT2
     SwitchGear Promoter luciferase reporter plasmids for CCT2
     ThermoFisher Antibody for CCT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCT2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCT2
     LSBio Antibodies in human, mouse, rat for CCT2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CCT2
      Search eBioscience for proteins for CCT2
      Search eBioscience for elisas for CCT2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCT2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4