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CCT2 Gene(Protein Coding)

Chaperonin Containing TCP1 Subunit 2

GCID:
GC12P069585
GIFtS:
60
Genes Participants
UDN Logo

Aliases for CCT2 Gene

Aliases for CCT2 Gene

  • Chaperonin Containing TCP1 Subunit 2 2 3 5
  • Chaperonin Containing TCP1, Subunit 2 (Beta) 2 3
  • TCP-1-Beta 3 4
  • CCT-Beta 3 4
  • 99D8.1 3 4
  • CCTB 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Beta Subunit 3
  • Chaperonin Containing T-Complex Polypeptide 1, Subunit 2 3
  • Epididymis Secretory Sperm Binding Protein Li 100n 3
  • T-Complex Protein 1, Beta Subunit 3
  • T-Complex Protein 1 Subunit Beta 3
  • HEL-S-100n 3
  • PRO1633 3

External Ids for CCT2 Gene

Previous GeneCards Identifiers for CCT2 Gene

  • GC12P069837
  • GC12P069695
  • GC12P068265
  • GC12P069979
  • GC12P067028

Summaries for CCT2 Gene

Entrez Gene Summary for CCT2 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CCT2 Gene

CCT2 (Chaperonin Containing TCP1 Subunit 2) is a Protein Coding gene. Diseases associated with CCT2 include Gallbladder Adenocarcinoma. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Chaperonin-mediated protein folding. GO annotations related to this gene include ubiquitin protein ligase binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CCT2 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT2 Gene

Genomics for CCT2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CCT2 Gene

Enhancers for CCT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G069986 1.4 FANTOM5 Ensembl ENCODE 21.3 +403.0 403039 2.7 TBP PKNOX1 ZSCAN4 ZNF76 GATA2 ZNF143 RCOR1 FOS CEBPB ZEB2 CCT2 MYRFL ENSG00000257815 RAB3IP ENSG00000257241 LOC100125409
GH12G069474 1.3 FANTOM5 Ensembl ENCODE 16.7 -109.9 -109916 2.0 SOX13 ZSCAN4 CEBPG RAD21 ZNF7 YY1 ZNF366 ZSCAN5C SCRT2 NR2F6 CCT2 FRS2 LYZ CPSF6 YEATS4 RAB3IP GC12P069484 GC12P069483
GH12G069994 0.9 FANTOM5 ENCODE 13.4 +409.4 409377 1.3 PKNOX1 ESRRA BHLHE40 ZNF394 PRDM6 NFIC PBX2 HNF4G HNF4A CCT2 MYRFL ENSG00000257815 RAB3IP ENSG00000257241 LOC100125409
GH12G069469 1.1 ENCODE 10.1 -114.5 -114485 2.1 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 CBX5 ZNF143 ZNF207 CCT2 LYZ FRS2 GC12P069483 GC12P069484
GH12G069404 1 Ensembl ENCODE 10 -179.8 -179828 2.8 GTF2F1 MXI1 TAF1 JUN MAX SIN3A FOSL1 GATA2 RCOR1 FOSL2 LYZ FRS2 CCT2 YEATS4 RN7SL804P RPS26P45
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCT2 on UCSC Golden Path with GeneCards custom track

Promoters for CCT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000053778 267 1600 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1

Transcription factor binding sites by QIAGEN in the CCT2 gene promoter:

Genomic Location for CCT2 Gene

Chromosome:
12
Start:
69,585,334 bp from pter
End:
69,601,577 bp from pter
Size:
16,244 bases
Orientation:
Plus strand

Genomic View for CCT2 Gene

Genes around CCT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCT2 Gene

Proteins for CCT2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78371-TCPB_HUMAN
    Recommended name:
    T-complex protein 1 subunit beta
    Protein Accession:
    P78371
    Secondary Accessions:
    • A8K402
    • B5BTY7
    • B7Z243
    • B7Z7K4
    • B7ZAT2
    • Q14D36
    • Q6IAT3

    Protein attributes for CCT2 Gene

    Size:
    535 amino acids
    Molecular mass:
    57488 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Interacts with FLCN (PubMed:27353360).

    Alternative splice isoforms for CCT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT2 Gene

Protein Expression for CCT2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCT2 Gene

  • Ubiquitination at Lys13, posLast=4040, posLast=4646, posLast=7272, posLast=8282, Lys120, Lys191, Lys204, posLast=236236, posLast=250250, Lys284, Lys342, Lys402, Lys441, and posLast=522522
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCT2 (CCT2)

No data available for DME Specific Peptides for CCT2 Gene

Domains & Families for CCT2 Gene

Gene Families for CCT2 Gene

HGNC:

Protein Domains for CCT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78371

UniProtKB/Swiss-Prot:

TCPB_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT2: view

Function for CCT2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CCT2 Gene

GENATLAS Biochemistry:
chaperonin containing TCP1,subunit 2 (beta),cytosolic,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Ontology (GO) - Molecular Function for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 21753002
GO:0044183 protein binding involved in protein folding IPI 25467444
GO:0051082 unfolded protein binding NAS 11532003
genes like me logo Genes that share ontologies with CCT2: view
genes like me logo Genes that share phenotypes with CCT2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT2 Gene

Localization for CCT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCT2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
lysosome 4
plasma membrane 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex IDA 23011926
genes like me logo Genes that share ontologies with CCT2: view

Pathways & Interactions for CCT2 Gene

genes like me logo Genes that share pathways with CCT2: view

SIGNOR curated interactions for CCT2 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0043312 neutrophil degranulation TAS --
GO:0050821 protein stabilization IMP 25467444
genes like me logo Genes that share ontologies with CCT2: view

Drugs & Compounds for CCT2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CCT2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CCT2 Gene

(2) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(826) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCT2 Gene

Chaperonin containing TCP1, subunit 2 (beta):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: - -

Relevant External Links for CCT2 Gene

GeneLoc Exon Structure for
CCT2
ECgene alternative splicing isoforms for
CCT2

Expression for CCT2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCT2 Gene

mRNA expression in normal human tissues for CCT2 Gene
mRNA expression by BioGPS for CCT2 GenemRNA expression by GTEx for CCT2 Gene

Protein differential expression in normal tissues from HIPED for CCT2 Gene

This gene is overexpressed in Lymph node (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCT2 Gene



Protein tissue co-expression partners for CCT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCT2 Gene:

CCT2

SOURCE GeneReport for Unigene cluster for CCT2 Gene:

Hs.189772

Evidence on tissue expression from TISSUES for CCT2 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Blood(4.4)
  • Lung(3.4)
  • Skin(3.4)
  • Eye(2.9)
  • Intestine(2.9)
  • Kidney(2.6)
  • Heart(2.4)
  • Gall bladder(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with CCT2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCT2 Gene

Orthologs for CCT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCT2 34 35
  • 99.88 (n)
oppossum
(Monodelphis domestica)
 Mammalia CCT2 35
  • 96 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CCT2 35
  • 96 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia CCT2 35 34
  • 93.15 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CCT2 34 35
  • 92.77 (n)
rat
(Rattus norvegicus)
 Mammalia Cct2 34
  • 90.16 (n)
mouse
(Mus musculus)
 Mammalia Cct2 34 16 35
  • 89.1 (n)
chicken
(Gallus gallus)
 Aves LRRC10 35
  • 93 (a)
 OneToOne
CCT2 34
  • 81.81 (n)
lizard
(Anolis carolinensis)
 Reptilia CCT2 35
  • 89 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cct2 34
  • 77.94 (n)
Str.1354 34
African clawed frog
(Xenopus laevis)
 Amphibia cct2-prov 34
zebrafish
(Danio rerio)
 Actinopterygii cct2 34 35
  • 72.21 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8395 34
fruit fly
(Drosophila melanogaster)
 Insecta CG7033 36 34 35
  • 62.78 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009694 34
  • 62.22 (n)
worm
(Caenorhabditis elegans)
 Secernentea cct-2 34 35
  • 61.92 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0C11451g 34
  • 63.96 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AER415W 34
  • 62.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CCT2 34 35 37
  • 61.89 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT5G20890 34
  • 64.81 (n)
soybean
(Glycine max)
 eudicotyledons Gma.4039 34
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.2222 34
rice
(Oryza sativa)
 Liliopsida Os05g0556700 34
  • 66.46 (n)
Os.8383 34
barley
(Hordeum vulgare)
 Liliopsida Hv.6194 34
corn
(Zea mays)
 Liliopsida Zm.6590 34
wheat
(Triticum aestivum)
 Liliopsida Ta.394 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.6937 35
  • 75 (a)
 OneToOne
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes cct2 34
  • 63.3 (n)
bread mold
(Neurospora crassa)
 Ascomycetes NCU02207 34
  • 62.01 (n)
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.2654 34
Species where no ortholog for CCT2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT2 Gene

ENSEMBL:
Gene Tree for CCT2 (if available)
TreeFam:
Gene Tree for CCT2 (if available)

Paralogs for CCT2 Gene

(8) SIMAP similar genes for CCT2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCT2 Gene

genes like me logo Genes that share paralogs with CCT2: view

No data available for Paralogs for CCT2 Gene

Variants for CCT2 Gene

Sequence variations from dbSNP and Humsavar for CCT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000082848 -- 69,599,442(+) GAGTG(C/G)AGAGG intron-variant
rs1000452957 -- 69,599,123(+) GCTCT(C/G)TTCCC intron-variant
rs1000470965 -- 69,594,031(+) CTTGG(C/G/T)GGGAG intron-variant
rs1000669405 -- 69,595,206(+) AGACG(-/T)TTTTT intron-variant
rs1001043671 -- 69,600,708(+) ATCCC(C/T)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCT2 Gene

Variant ID Type Subtype PubMed ID
dgv1523n100 CNV gain 25217958
nsv1113492 CNV deletion 24896259

Variation tolerance for CCT2 Gene

Residual Variation Intolerance Score: 11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT2 Gene

Human Gene Mutation Database (HGMD)
CCT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCT2 Gene

Disorders for CCT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gallbladder adenocarcinoma
  • adenocarcinoma of the gallbladder
- elite association - COSMIC cancer census association via MalaCards
Search CCT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCT2

Genetic Association Database (GAD)
CCT2
Human Genome Epidemiology (HuGE) Navigator
CCT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT2
genes like me logo Genes that share disorders with CCT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT2 Gene

Publications for CCT2 Gene

  1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won K.-A. … Reed S.I. (Mol. Cell. Biol. 1998) 2 3 4 64
  2. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. (PMID: 27353360) Woodford M.R. … Mollapour M. (Nat. Commun. 2016) 3 4 64
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  5. BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. (PMID: 20080638) Seo S. … Sheffield V.C. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64

Products for CCT2 Gene

  • Cloud-Clone Corp. Antibodies for CCT2
  • Cloud-Clone Corp. Proteins for CCT2
  • Cloud-Clone Corp Assay Kits for CCT2

Sources for CCT2 Gene

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