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Aliases for CCT2 Gene

Aliases for CCT2 Gene

  • Chaperonin Containing TCP1 Subunit 2 2 3
  • Chaperonin Containing TCP1, Subunit 2 (Beta) 2 3 5
  • TCP-1-Beta 3 4
  • CCT-Beta 3 4
  • 99D8.1 3 4
  • CCTB 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Beta Subunit 3
  • Chaperonin Containing T-Complex Polypeptide 1, Subunit 2 3
  • Epididymis Secretory Sperm Binding Protein Li 100n 3
  • T-Complex Protein 1, Beta Subunit 3
  • HEL-S-100n 3
  • PRO1633 3

External Ids for CCT2 Gene

Previous GeneCards Identifiers for CCT2 Gene

  • GC12P069837
  • GC12P069695
  • GC12P068265
  • GC12P069979
  • GC12P067028

Summaries for CCT2 Gene

Entrez Gene Summary for CCT2 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CCT2 Gene

CCT2 (Chaperonin Containing TCP1 Subunit 2) is a Protein Coding gene. Diseases associated with CCT2 include gallbladder adenocarcinoma and bardet-biedl syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding. GO annotations related to this gene include ubiquitin protein ligase binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CCT2 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT2 Gene

Genomics for CCT2 Gene

Regulatory Elements for CCT2 Gene

Promoters for CCT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCT2 Gene

Chromosome:
12
Start:
69,585,334 bp from pter
End:
69,601,577 bp from pter
Size:
16,244 bases
Orientation:
Plus strand

Genomic View for CCT2 Gene

Genes around CCT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT2 Gene

Proteins for CCT2 Gene

  • Protein details for CCT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78371-TCPB_HUMAN
    Recommended name:
    T-complex protein 1 subunit beta
    Protein Accession:
    P78371
    Secondary Accessions:
    • A8K402
    • B5BTY7
    • B7Z243
    • B7Z7K4
    • B7ZAT2
    • Q14D36
    • Q6IAT3

    Protein attributes for CCT2 Gene

    Size:
    535 amino acids
    Molecular mass:
    57488 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.

    Alternative splice isoforms for CCT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT2 Gene

Proteomics data for CCT2 Gene at MOPED

Post-translational modifications for CCT2 Gene

  • Ubiquitination at Lys 13, Lys 40, Lys 46, Lys 72, Lys 82, Lys 120, Lys 191, Lys 204, Lys 236, Lys 250, Lys 284, Lys 342, Lys 402, Lys 441, and Lys 522
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCT2 (CCT2)

No data available for DME Specific Peptides for CCT2 Gene

Domains & Families for CCT2 Gene

Gene Families for CCT2 Gene

Graphical View of Domain Structure for InterPro Entry

P78371

UniProtKB/Swiss-Prot:

TCPB_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT2: view

Function for CCT2 Gene

Molecular function for CCT2 Gene

GENATLAS Biochemistry:
chaperonin containing TCP1,subunit 2 (beta),cytosolic,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
genes like me logo Genes that share phenotypes with CCT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCT2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCT2 Gene

Localization for CCT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT2 Gene COMPARTMENTS Subcellular localization image for CCT2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CCT2 Gene

Pathways & Interactions for CCT2 Gene

genes like me logo Genes that share pathways with CCT2: view

SIGNOR curated interactions for CCT2 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
GO:0044267 cellular protein metabolic process TAS --
GO:0050821 protein stabilization IMP 25467444
GO:0090666 scaRNA localization to Cajal body IMP 25467444
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with CCT2: view

Drugs & Compounds for CCT2 Gene

No Compound Related Data Available

Transcripts for CCT2 Gene

Unigene Clusters for CCT2 Gene

Chaperonin containing TCP1, subunit 2 (beta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCT2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: - -

Relevant External Links for CCT2 Gene

GeneLoc Exon Structure for
CCT2
ECgene alternative splicing isoforms for
CCT2

Expression for CCT2 Gene

mRNA expression in normal human tissues for CCT2 Gene

Protein differential expression in normal tissues from HIPED for CCT2 Gene

This gene is overexpressed in Lymph node (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT2 Gene



SOURCE GeneReport for Unigene cluster for CCT2 Gene Hs.189772

genes like me logo Genes that share expression patterns with CCT2: view

Protein tissue co-expression partners for CCT2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT2 Gene

Orthologs for CCT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCT2 35
  • 93.15 (n)
  • 98.13 (a)
CCT2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT2 35
  • 92.77 (n)
  • 98.32 (a)
CCT2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct2 35
  • 89.1 (n)
  • 97.57 (a)
Cct2 16
Cct2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCT2 35
  • 99.88 (n)
  • 100 (a)
CCT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct2 35
  • 90.16 (n)
  • 97.76 (a)
oppossum
(Monodelphis domestica)
Mammalia CCT2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCT2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCT2 35
  • 81.81 (n)
  • 93.08 (a)
LRRC10 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cct2 35
  • 77.94 (n)
  • 90.84 (a)
Str.1354 35
African clawed frog
(Xenopus laevis)
Amphibia cct2-prov 35
zebrafish
(Danio rerio)
Actinopterygii cct2 35
  • 72.21 (n)
  • 87.48 (a)
cct2 36
  • 84 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8395 35
fruit fly
(Drosophila melanogaster)
Insecta CG7033 37
  • 71 (a)
CG7033 35
  • 62.78 (n)
  • 71.43 (a)
CG7033 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009694 35
  • 62.22 (n)
  • 73.14 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-2 35
  • 61.92 (n)
  • 66.98 (a)
cct-2 36
  • 67 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER415W 35
  • 62.15 (n)
  • 65.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11451g 35
  • 63.96 (n)
  • 65.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT2 35
  • 61.89 (n)
  • 66.16 (a)
CCT2 36
  • 65 (a)
OneToOne
CCT2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G20890 35
  • 64.81 (n)
  • 68.14 (a)
soybean
(Glycine max)
eudicotyledons Gma.4039 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2222 35
barley
(Hordeum vulgare)
Liliopsida Hv.6194 35
rice
(Oryza sativa)
Liliopsida Os.8383 35
Os05g0556700 35
  • 66.46 (n)
  • 70.28 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.394 35
corn
(Zea mays)
Liliopsida Zm.6590 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2654 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02207 35
  • 62.01 (n)
  • 68.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct2 35
  • 63.3 (n)
  • 67.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6937 36
  • 75 (a)
OneToOne
Species with no ortholog for CCT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT2 Gene

ENSEMBL:
Gene Tree for CCT2 (if available)
TreeFam:
Gene Tree for CCT2 (if available)

Paralogs for CCT2 Gene

(8) SIMAP similar genes for CCT2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCT2 Gene

genes like me logo Genes that share paralogs with CCT2: view

No data available for Paralogs for CCT2 Gene

Variants for CCT2 Gene

Sequence variations from dbSNP and Humsavar for CCT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7200 -- 69,601,493(+) CCGTG(C/T)CATTT utr-variant-3-prime
rs8237 -- 69,599,934(+) GNCAG(G/T)TTCTT reference, missense
rs11324 -- 69,599,987(+) AACAT(C/G/T)ATCAA reference, synonymous-codon, missense
rs482640 -- 69,590,302(-) ACTGG(C/T)TCCAA intron-variant
rs35639 -- 69,597,895(+) GCATA(C/T)CTTAA intron-variant

Variation tolerance for CCT2 Gene

Residual Variation Intolerance Score: 11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCT2 Gene

HapMap Linkage Disequilibrium report
CCT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCT2 Gene

Disorders for CCT2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gallbladder adenocarcinoma
  • adenocarcinoma of the gallbladder
bardet-biedl syndrome
  • laurence-moon syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CCT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCT2

Genetic Association Database (GAD)
CCT2
Human Genome Epidemiology (HuGE) Navigator
CCT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCT2
genes like me logo Genes that share disorders with CCT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCT2 Gene

Publications for CCT2 Gene

  1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won K.-A. … Reed S.I. (Mol. Cell. Biol. 1998) 2 3 4 67
  2. Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin. (PMID: 10748209) Hynes G.M. … Willison K.R. (J. Biol. Chem. 2000) 3 23
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes. (PMID: 25704758) Guest S.T. … Ethier S.P. (Exp. Cell Res. 2015) 3
  5. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. (PMID: 25817432) Gallina I. … Lisby M. (Nat Commun 2015) 3

Products for CCT2 Gene

Sources for CCT2 Gene

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