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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCT2 Gene

protein-coding   GIFtS: 65
GCID: GC12P069979

Chaperonin Containing TCP1, Subunit 2 (Beta)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chaperonin Containing TCP1, Subunit 2 (Beta)1 2     PRO16332
CCTB2 3 5     Chaperonin Containing T-Complex Polypeptide 1, Beta Subunit2
99D8.12 3     Chaperonin Containing T-Complex Polypeptide 1, Subunit 22
CCT-beta2 3     T-Complex Protein 1 Subunit Beta2
TCP-1-beta2 3     T-Complex Protein 1, Beta Subunit2

External Ids:    HGNC: 16151   Entrez Gene: 105762   Ensembl: ENSG000001662267   OMIM: 6051395   UniProtKB: P783713   

Export aliases for CCT2 gene to outside databases

Previous GC identifers: GC12P069837 GC12P069695 GC12P068265 GC12P067028


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCT2 Gene:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1
complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings,
each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are
folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for CCT2 Gene: 
CCT2 (chaperonin containing TCP1, subunit 2 (beta)) is a protein-coding gene. Diseases associated with CCT2 include cecum cancer, and cerebral cavernous malformations 3, and among its related super-pathways are Formation of tubulin folding intermediates by CCT/TriC and Chaperonin-mediated protein folding. GO annotations related to this gene include unfolded protein binding and ATP binding.

UniProtKB/Swiss-Prot: TCPB_HUMAN, P78371
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for CCT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCT2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   Nkx2-5   POU3F2   LCR-F1   GATA-2   Nkx3-1 v2   FOXO4   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q15   HGNC cytogenetic band: 12q14

CCT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCT2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P069979:  view genomic region     (about GC identifiers)

Start:
69,979,114 bp from pter      End:
69,995,357 bp from pter
Size:
16,244 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCPB_HUMAN, P78371 (See protein sequence)
Recommended Name: T-complex protein 1 subunit beta  
Size: 535 amino acids; 57488 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8
Subcellular location: Cytoplasm
Secondary accessions: A8K402 B5BTY7 B7Z243 B7Z7K4 B7ZAT2 Q14D36 Q6IAT3
Alternative splicing: 2 isoforms:  P78371-1   P78371-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCT2: NX_P78371

Explore proteomics data for CCT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78371

  • CCT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCT2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001185771.1  NP_006422.1  

    ENSEMBL proteins: 
     ENSP00000299300   ENSP00000441847   ENSP00000450153   ENSP00000445471  
    Reactome Protein details: P78371
    Human Recombinant Protein Products for CCT2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for CCT2
    OriGene MassSpec for CCT2 
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    Novus Biologicals CCT2 Proteins
    Novus Biologicals CCT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCT2 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    CCT2 for ontologies           About GeneDecksing



    CCT2 Antibody Products: 
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    Novus Biologicals CCT2 Antibodies
    Abcam antibodies for CCT2
    Cloud-Clone Corp. Antibodies for CCT2 
    ThermoFisher Antibody for CCT2
    LSBio Antibodies in human, mouse, rat for CCT2 

    Assay Products for CCT2: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CCT2 
    Cloud-Clone Corp. CLIAs for CCT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHAP: Heat Shock Proteins / Chaperonins

    5/7 InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR002194 Chaperonin_TCP-1_CS
     IPR012716 Chap_CCT_beta
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom

    Graphical View of Domain Structure for InterPro Entry P78371

    ProtoNet protein and cluster: P78371

    2 Blocks protein domains:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPB_HUMAN, P78371
    Similarity: Belongs to the TCP-1 chaperonin family


    CCT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPB_HUMAN, P78371
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
    may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
    the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

         Genatlas biochemistry entry for CCT2:
    chaperonin containing TCP1,subunit 2 (beta),cytosolic,TF55/TCP-1 family

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding NAS11532003
         
    CCT2 for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for CCT2:
     Cell division defect  Decreased CYP1A1 activity afte  Decreased viability of wild-ty  Increased G2M DNA content 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce  Prevent p53-dependent growth a  Synthetic lethal with Ras 
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCT2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCT2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCT2:
    hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCT2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCT2 (NM_006431)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT2
    Sirion Biotech Customized lentivirus for stable overexpression of CCT2 
                         Customized lentivirus expression plasmids for stable overexpression of CCT2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CCT2
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Formation of tubulin folding intermediates by CCT/TriC
    Formation of tubulin folding intermediates by CCT/TriC0.74
    Prefoldin mediated transfer of substrate to CCT/TriC0.70
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.74
    Folding of actin by CCT/TriC0.38
    2Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    3Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation0.98
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCT2
        Cell cycle Role of APC in cell cycle regulation


    1 GeneGo (Thomson Reuters) Pathway for CCT2
        Cell cycle Role of APC in cell cycle regulation

    5/8        Reactome Pathways for CCT2 (see all 8)
        Formation of tubulin folding intermediates by CCT/TriC
    Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Prefoldin mediated transfer of substrate to CCT/TriC
    Metabolism of proteins



    CCT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1061 Interacting proteins for CCT2 (P783711, 2, 3 ENSP000002993004) via UniProtKB, MINT, STRING, and/or I2D (see all 1061)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--
    GO:0051131chaperone-mediated protein complex assembly IMP--

    CCT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCT2 (TCPB)

    Search CenterWatch for drugs/clinical trials and news about CCT2 / TCPB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCT2 gene (2 alternative transcripts): 
    NM_001198842.1  NM_006431.2  

    Unigene Cluster for CCT2:

    Chaperonin containing TCP1, subunit 2 (beta)
    Hs.189772  [show with all ESTs]
    Unigene Representative Sequence: NM_001198842
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299300(uc001svb.1) ENST00000546859 ENST00000549933 ENST00000550455
    ENST00000550638 ENST00000551620 ENST00000551899 ENST00000544368 ENST00000550010
    ENST00000543146(uc010stl.1) ENST00000548787 ENST00000546850 ENST00000553169
    ENST00000550653
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCT2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCT2:
    hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCT2 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCT2
    Clone
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    OriGene clones in human, mouse for CCT2 (see all 9)
    OriGene ORF clones in mouse, rat for CCT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCT2 (NM_006431)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCT2
    Sirion Biotech Customized lentivirus for stable overexpression of CCT2 
                         Customized lentivirus expression plasmids for stable overexpression of CCT2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCT2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCT2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT2

    Additional mRNA sequence: 

    AB451223.1 AB451346.1 AF026166.1 AF026293.1 AK290767.1 AK294307.1 AK297685.1 AK302157.1 
    AK316397.1 AK316408.1 BC113514.1 BC113516.1 BT019966.1 CR457071.1 

    24/27 DOTS entries (see all 27):

    DT.95366739  DT.95228517  DT.95366744  DT.100848412  DT.100848417  DT.95334620  DT.100848410  DT.100848405 
    DT.121194487  DT.121194472  DT.100848402  DT.121194449  DT.40225073  DT.40240828  DT.92459856  DT.95071193 
    DT.95366729  DT.95366749  DT.100731827  DT.100773145  DT.100848404  DT.121194503  DT.91652122  DT.95366737 

    24/826 AceView cDNA sequences (see all 826):

    AU120401 BM849579 AA307298 BQ959393 BF797374 AI589986 CD640923 BM764593 
    BU627773 BM854255 BM680413 CA777073 BM471111 BM790238 CA416238 BM999485 
    AL121077 BM788772 AA574025 AI082436 BM834792 BE551072 CB115756 BQ424813 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CCT2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:              -     -                 -     -           -           -           -           -                                                               
    SP2:              -     -                 -     -           -           -           -                                                                           
    SP3:                                      -     -           -           -           -                                                                           
    SP4:              -     -                 -     -           -           -                                                                                       
    SP5:                                                                    -           -           -                 -                                             


    ECgene alternative splicing isoforms for CCT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGACACA
    CCT2 Expression
    About this image


    See CCT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCT2

    SOURCE GeneReport for Unigene cluster: Hs.189772
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCT2: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCT2 gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cct21 , 5 chaperonin containing Tcp1, subunit 2 (beta)1, 5 89.1(n)1
    97.57(a)1
      10 (65.07 cM)5
    124611  NM_007636.21  NP_031662.21 
     1170509985 
    chicken
    (Gallus gallus)
    Aves CCT21 chaperonin containing TCP1, subunit 2 (beta) 81.81(n)
    93.08(a)
      417846  NM_001012533.1  NP_001012551.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCT26
    Uncharacterized protein
    89(a)
    1 ↔ 1
    GL343256.1(1643840-1653857)
    African clawed frog
    (Xenopus laevis)
    Amphibia cct2-prov2 chaperonin subunit 2 (beta) 78.98(n)    BC042347.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cct22 chaperonin containing TCP1, subunit 2 (beta) 74.36(n)   192326  BC059558.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70331 , 3 chaperone3
    CG70331
    71(a)3
    62.78(n)1
    71.43(a)1
      8C83
    318381  NM_132296.31  NP_572524.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cct-21 Protein CCT-2 61.92(n)
    66.98(a)
      174421  NM_171985.4  NP_741031.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCT2(YIL142W)4
    CCT21
    Subunit beta of the cytosolic chaperonin Cct ring complex, more4
    Cct2p1
    61.89(n)1
    65.97(a)1
      9(83302-84885)4
    8546641, 4  NP_012124.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G208901 TCP-1/cpn60 chaperonin family protein 64.93(n)
    68.34(a)
      832213  NM_122097.2  NP_197589.1 
    rice
    (Oryza sativa)
    Liliopsida Os.83832 Oryza sativa (japonica cultivar-group) cDNA clone0 more 75.95(n)    AK059663.1 


    ENSEMBL Gene Tree for CCT2 (if available)
    TreeFam Gene Tree for CCT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCT2 gene
    8 SIMAP similar genes for CCT2 using alignment to 3 protein entries:     TCPB_HUMAN (see all proteins):
    CCT5    TCP1    CCT3    CCT7    CCT4    CCT6B
    CCT6A    CCT8

    CCT2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCT2
    PGOHUM00000261534


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/391 SNPs in CCT2 are shown (see all 391)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021861721,2
    C,F--69980614(+) TAGAAA/GAGTTT 2 -- int11Minor allele frequency- G:0.00EU 819
    rs1440561261,2
    C--69980645(+) GAGCGC/TTTGGT 2 -- int10--------
    rs1403940161,2
    C--69980705(+) TTAAT-/TATAAAA 2 -- int10--------
    rs1473015191,2
    --69980780(+) CCTCCC/GCAATG 2 -- int10--------
    rs768176751,2
    F--69980808(+) TTGCAC/TGTACA 2 -- int11Minor allele frequency- T:0.01EA 120
    rs1488143671,2
    C--69980895(+) AAAAC-/AGATACT 2 -- int10--------
    rs1487577111,2
    --69980946(+) CTTTCA/GGTGTA 2 -- int10--------
    rs2016244571,2
    C--69981030(-) ACTATA/CAATAC 2 -- int10--------
    rs111777321,2
    C,F,H--69981111(+) TAGGGG/ATAGAT 2 -- int110Minor allele frequency- A:0.18NS EA NA CSA WA 776
    rs1997867131,2
    C--69981128(+) TTTGG-/TTACGTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CCT2 (69979114 - 69995357 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCT2: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CCT2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605139    OMIM disorders: --

    12 diseases for CCT2:    About MalaCards
    cecum cancer    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation
    cerebritis    intrahepatic cholangiocarcinoma    cholangiocarcinoma    influenza
    pancreatic cancer    gastric cancer    pancreatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CCT2:
    Cecum cancer

    CCT2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CCT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 28 1 11795471 (1)

    Genetic Association Database (GAD): CCT2
    Human Genome Epidemiology (HuGE) Navigator: CCT2 (2 documents)

    Export disorders for CCT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCT2 gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with CCT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PubMed id 9819444)1, 2, 3 Won K.-A.... Reed S.I. (1998)
    2. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    3. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    4. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    8. Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin. (PubMed id 10748209)1, 9 Hynes G.M. and Willison K.R. (2000)
    9. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    10. The novel ubiquitin ligase complex, SCF(Fbxw4), intera cts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10576 HGNC: 1615 AceView: CCT2 Ensembl:ENSG00000166226 euGenes: HUgn10576
    ECgene: CCT2 H-InvDB: CCT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCT2 gene:
    Search GeneIP for patents involving CCT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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