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Aliases for CCT2 Gene

Aliases for CCT2 Gene

  • Chaperonin Containing TCP1, Subunit 2 (Beta) 2 3
  • CCTB 3 4 6
  • TCP-1-Beta 3 4
  • CCT-Beta 3 4
  • 99D8.1 3 4
  • Chaperonin Containing T-Complex Polypeptide 1, Beta Subunit 3
  • Chaperonin Containing T-Complex Polypeptide 1, Subunit 2 3
  • Epididymis Secretory Sperm Binding Protein Li 100n 3
  • T-Complex Protein 1, Beta Subunit 3
  • T-Complex Protein 1 Subunit Beta 3
  • HEL-S-100n 3
  • PRO1633 3

External Ids for CCT2 Gene

Previous GeneCards Identifiers for CCT2 Gene

  • GC12P069837
  • GC12P069695
  • GC12P068265
  • GC12P069979
  • GC12P067028

Summaries for CCT2 Gene

Entrez Gene Summary for CCT2 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CCT2 Gene

CCT2 (Chaperonin Containing TCP1, Subunit 2 (Beta)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for CCT2 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for CCT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCT2 Gene

Genomics for CCT2 Gene

Regulatory Elements for CCT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCT2 Gene

Start:
69,585,334 bp from pter
End:
69,601,577 bp from pter
Size:
16,244 bases
Orientation:
Plus strand

Genomic View for CCT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCT2 Gene

Proteins for CCT2 Gene

  • Protein details for CCT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78371-TCPB_HUMAN
    Recommended name:
    T-complex protein 1 subunit beta
    Protein Accession:
    P78371
    Secondary Accessions:
    • A8K402
    • B5BTY7
    • B7Z243
    • B7Z7K4
    • B7ZAT2
    • Q14D36
    • Q6IAT3

    Protein attributes for CCT2 Gene

    Size:
    535 amino acids
    Molecular mass:
    57488 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.

    Alternative splice isoforms for CCT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCT2 Gene

Proteomics data for CCT2 Gene at MOPED

Post-translational modifications for CCT2 Gene

  • Ubiquitination at Lys13, Lys40, Lys46, Lys72, Lys82, Lys120, Lys154, Lys191, Lys204, Lys236, Lys248, Lys250, Lys284, Lys342, Lys402, Lys441, and Lys522
  • Modification sites at PhosphoSitePlus

Other Protein References for CCT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCT2 (CCT-beta)

No data available for DME Specific Peptides for CCT2 Gene

Domains for CCT2 Gene

Gene Families for CCT2 Gene

HGNC:
  • CHAP :Heat Shock Proteins / Chaperonins

Graphical View of Domain Structure for InterPro Entry

P78371

UniProtKB/Swiss-Prot:

TCPB_HUMAN :
  • P78371
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with CCT2: view

Function for CCT2 Gene

Molecular function for CCT2 Gene

GENATLAS Biochemistry: chaperonin containing TCP1,subunit 2 (beta),cytosolic,TF55/TCP-1 family
UniProtKB/Swiss-Prot Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Ontology (GO) - Molecular Function for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 21753002
GO:0051082 unfolded protein binding NAS 11532003
genes like me logo Genes that share ontologies with CCT2: view
genes like me logo Genes that share phenotypes with CCT2: view

Animal Model Products

miRNA for CCT2 Gene

miRTarBase miRNAs that target CCT2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCT2 Gene

Localization for CCT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCT2 Gene COMPARTMENTS Subcellular localization image for CCT2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005832 chaperonin-containing T-complex IDA 23011926
GO:0005874 microtubule IDA 21525035
genes like me logo Genes that share ontologies with CCT2: view

Pathways for CCT2 Gene

genes like me logo Genes that share pathways with CCT2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
GO:0051131 chaperone-mediated protein complex assembly IMP 20080638
genes like me logo Genes that share ontologies with CCT2: view

Transcripts for CCT2 Gene

Unigene Clusters for CCT2 Gene

Chaperonin containing TCP1, subunit 2 (beta):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCT2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CCT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCT2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: - -

Relevant External Links for CCT2 Gene

GeneLoc Exon Structure for
CCT2
ECgene alternative splicing isoforms for
CCT2

Expression for CCT2 Gene

mRNA expression in normal human tissues for CCT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCT2 Gene

SOURCE GeneReport for Unigene cluster for CCT2 Gene Hs.189772

genes like me logo Genes that share expressions with CCT2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCT2 Gene

Orthologs for CCT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCT2 35
  • 99.88 (n)
  • 100 (a)
CCT2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCT2 35
  • 93.15 (n)
  • 98.13 (a)
CCT2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCT2 35
  • 92.77 (n)
  • 98.32 (a)
CCT2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cct2 35
  • 89.1 (n)
  • 97.57 (a)
Cct2 16
Cct2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCT2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCT2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cct2 35
  • 90.16 (n)
  • 97.76 (a)
chicken
(Gallus gallus)
Aves CCT2 35
  • 81.81 (n)
  • 93.08 (a)
LRRC10 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCT2 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cct2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cct2 35
  • 77.94 (n)
  • 90.84 (a)
Str.1354 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8395 35
zebrafish
(Danio rerio)
Actinopterygii cct2 35
  • 72.21 (n)
  • 87.48 (a)
cct2 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009694 35
  • 62.22 (n)
  • 73.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7033 35
  • 62.78 (n)
  • 71.43 (a)
CG7033 36
  • 71 (a)
OneToOne
CG7033 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-2 35
  • 61.92 (n)
  • 66.98 (a)
cct-2 36
  • 67 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER415W 35
  • 62.15 (n)
  • 65.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCT2 35
  • 61.89 (n)
  • 66.16 (a)
CCT2 36
  • 65 (a)
OneToOne
CCT2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11451g 35
  • 63.96 (n)
  • 65.76 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2222 35
soybean
(Glycine max)
eudicotyledons Gma.4039 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G20890 35
  • 64.81 (n)
  • 68.14 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6194 35
corn
(Zea mays)
Liliopsida Zm.6590 35
rice
(Oryza sativa)
Liliopsida Os.8383 35
Os05g0556700 35
  • 66.46 (n)
  • 70.28 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.394 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02207 35
  • 62.01 (n)
  • 68.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct2 35
  • 63.3 (n)
  • 67.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2654 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6937 36
  • 75 (a)
OneToOne
Species with no ortholog for CCT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCT2 Gene

ENSEMBL:
Gene Tree for CCT2 (if available)
TreeFam:
Gene Tree for CCT2 (if available)

Paralogs for CCT2 Gene

Selected SIMAP similar genes for CCT2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCT2 Gene

genes like me logo Genes that share paralogs with CCT2: view

No data available for Paralogs for CCT2 Gene

Variants for CCT2 Gene

Sequence variations from dbSNP and Humsavar for CCT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7200 -- 69,601,493(+) CCGTG(C/T)CATTT utr-variant-3-prime
rs8237 -- 69,599,934(+) GNCAG(G/T)TTCTT reference, missense
rs11324 -- 69,599,987(+) AACAT(C/T)ATCAA reference, synonymous-codon
rs35639 -- 69,597,895(+) GCATA(C/T)CTTAA intron-variant
rs35640 -- 69,599,037(+) TGATA(C/T)GTTGT intron-variant

Relevant External Links for CCT2 Gene

HapMap Linkage Disequilibrium report
CCT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCT2 Gene

Disorders for CCT2 Gene

(1) University of Copenhagen DISEASES for CCT2 Gene

(1) Novoseek inferred disease relationships for CCT2 Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 28 1

Relevant External Links for CCT2

Genetic Association Database (GAD)
CCT2
Human Genome Epidemiology (HuGE) Navigator
CCT2
genes like me logo Genes that share disorders with CCT2: view

No data available for UniProtKB/Swiss-Prot for CCT2 Gene

Publications for CCT2 Gene

  1. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. (PMID: 9819444) Won K.-A. … Reed S.I. (Mol. Cell. Biol. 1998) 2 3 4
  2. Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin. (PMID: 10748209) Hynes G.M. … Willison K.R. (J. Biol. Chem. 2000) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4

Products for CCT2 Gene

Sources for CCT2 Gene

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