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Aliases for CCSER2 Gene

Aliases for CCSER2 Gene

  • Coiled-Coil Serine Rich Protein 2 2 3 5
  • Coiled-Coil Serine-Rich Protein 2 2 3 4
  • KIAA1128 2 3 4
  • Family With Sequence Similarity 190, Member B 2 3
  • Protein GCAP14 Homolog 3 4
  • FAM190B 3 4
  • Protein FAM190B 3
  • BA486O22.1 3
  • Gcap14 3

External Ids for CCSER2 Gene

Previous HGNC Symbols for CCSER2 Gene

  • KIAA1128
  • FAM190B

Previous GeneCards Identifiers for CCSER2 Gene

  • GC10P086088

Summaries for CCSER2 Gene

GeneCards Summary for CCSER2 Gene

CCSER2 (Coiled-Coil Serine Rich Protein 2) is a Protein Coding gene. GO annotations related to this gene include microtubule binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCSER2 Gene

Genomics for CCSER2 Gene

Regulatory Elements for CCSER2 Gene

Promoters for CCSER2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCSER2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCSER2 Gene

Chromosome:
10
Start:
84,328,586 bp from pter
End:
84,518,521 bp from pter
Size:
189,936 bases
Orientation:
Plus strand

Genomic View for CCSER2 Gene

Genes around CCSER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCSER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCSER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCSER2 Gene

Proteins for CCSER2 Gene

  • Protein details for CCSER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7U1-CCSE2_HUMAN
    Recommended name:
    Serine-rich coiled-coil domain-containing protein 2
    Protein Accession:
    Q9H7U1
    Secondary Accessions:
    • B4DFY4
    • B4DQU9
    • B7WPE8
    • D3DWE2
    • Q8N6E9
    • Q9H2S0
    • Q9ULU1

    Protein attributes for CCSER2 Gene

    Size:
    834 amino acids
    Molecular mass:
    93548 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG44473.1; Type=Frameshift; Positions=187, 240, 244; Evidence={ECO:0000305}; Sequence=AAH30528.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI40902.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CCSER2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCSER2 Gene

Proteomics data for CCSER2 Gene at MOPED

Post-translational modifications for CCSER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCSER2 Gene

No data available for DME Specific Peptides for CCSER2 Gene

Domains & Families for CCSER2 Gene

Protein Domains for CCSER2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCSER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7U1

UniProtKB/Swiss-Prot:

CCSE2_HUMAN :
  • Belongs to the CCSER family.
Family:
  • Belongs to the CCSER family.
genes like me logo Genes that share domains with CCSER2: view

No data available for Gene Families for CCSER2 Gene

Function for CCSER2 Gene

genes like me logo Genes that share phenotypes with CCSER2: view

Animal Model Products

miRNA for CCSER2 Gene

miRTarBase miRNAs that target CCSER2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCSER2 Gene

Localization for CCSER2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCSER2 Gene

Pathways & Interactions for CCSER2 Gene

SuperPathways for CCSER2 Gene

No Data Available

Interacting Proteins for CCSER2 Gene

Gene Ontology (GO) - Biological Process for CCSER2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCSER2 Gene

Drugs & Compounds for CCSER2 Gene

No Compound Related Data Available

Transcripts for CCSER2 Gene

Unigene Clusters for CCSER2 Gene

Coiled-coil serine-rich protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCSER2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CCSER2 Gene

GeneLoc Exon Structure for
CCSER2
ECgene alternative splicing isoforms for
CCSER2

Expression for CCSER2 Gene

mRNA expression in normal human tissues for CCSER2 Gene

Protein differential expression in normal tissues from HIPED for CCSER2 Gene

This gene is overexpressed in Tlymphocyte (28.1), Heart (27.2), and Urinary Bladder (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCSER2 Gene



SOURCE GeneReport for Unigene cluster for CCSER2 Gene Hs.461988

genes like me logo Genes that share expression patterns with CCSER2: view

Protein tissue co-expression partners for CCSER2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCSER2 Gene

Orthologs for CCSER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCSER2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM190B 35
  • 90.96 (n)
  • 86.53 (a)
CCSER2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM190B 35
  • 91.48 (n)
  • 87.37 (a)
CCSER2 36
  • 27 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccser2 35
  • 84.4 (n)
  • 82.22 (a)
Ccser2 16
Ccser2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA1128 35
  • 99.59 (n)
  • 99.33 (a)
CCSER2 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccser2 35
  • 85.2 (n)
  • 80.79 (a)
oppossum
(Monodelphis domestica)
Mammalia CCSER2 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCSER2 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM190B 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCSER2 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17140 35
zebrafish
(Danio rerio)
Actinopterygii ccser2 36
  • 27 (a)
OneToMany
CCSER2 (1 of 2) 36
  • 35 (a)
OneToMany
Species with no ortholog for CCSER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCSER2 Gene

ENSEMBL:
Gene Tree for CCSER2 (if available)
TreeFam:
Gene Tree for CCSER2 (if available)

Paralogs for CCSER2 Gene

Pseudogenes.org Pseudogenes for CCSER2 Gene

genes like me logo Genes that share paralogs with CCSER2: view

No data available for Paralogs for CCSER2 Gene

Variants for CCSER2 Gene

Sequence variations from dbSNP and Humsavar for CCSER2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3814205 - 84,371,303(-) GAGTA(C/T)TGTTA nc-transcript-variant, reference, missense
rs11201058 - 84,477,603(+) AAAAT(A/G)TAAAG nc-transcript-variant, reference, missense
rs11557865 - 84,513,493(+) ACAGA(C/T)CACAC reference, synonymous-codon, missense
rs12569751 - 84,513,499(+) CACAC(C/T)CAGGG reference, synonymous-codon, missense
rs2960 -- 84,392,255(-) CTCCA(C/G)ATGTT intron-variant, upstream-variant-2KB

Variation tolerance for CCSER2 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCSER2 Gene

HapMap Linkage Disequilibrium report
CCSER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCSER2 Gene

Disorders for CCSER2 Gene

Relevant External Links for CCSER2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCSER2

No disorders were found for CCSER2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCSER2 Gene

Publications for CCSER2 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for CCSER2 Gene

Sources for CCSER2 Gene

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