Aliases for CCSER2 Gene
Aliases for CCSER2 Gene
External Ids for CCSER2 Gene
- HGNC: 29197
- Entrez Gene: 54462
- Ensembl: ENSG00000107771
- UniProtKB: Q9H7U1
Previous HGNC Symbols for CCSER2 Gene
- KIAA1128
- FAM190B
Previous GeneCards Identifiers for CCSER2 Gene
- GC10P086088
Summaries for CCSER2 Gene
GeneCards Summary for CCSER2 Gene
CCSER2 (Coiled-Coil Serine Rich Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding.
Additional gene information for CCSER2 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCSER2 Gene
Genomics for CCSER2 Gene
GeneHancer (GH) Regulatory Elements for CCSER2 Gene
Promoters and enhancers for CCSER2 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10I084327 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 568.9 | +1.1 | 1084 | 5.1 | HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A YY1 POLR2B ZNF766 | CCSER2 RPL12P29 | |
GH10I084423 | Promoter/Enhancer | 1.2 | EPDnew Ensembl ENCODE | 555.6 | +96.5 | 96525 | 2.6 | ZNF335 POLR2A JUN RUNX3 ZNF518A GABPA YY1 | CCSER2 GC10M084418 GC10M084379 | |
GH10I084333 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 12.9 | +6.9 | 6945 | 4.7 | HDAC1 PKNOX1 SIN3A TCF12 EGR1 SCRT2 RCOR1 FOS IKZF2 RUNX3 | CCSER2 RPL12P29 | |
GH10I084267 | Enhancer | 0.8 | Ensembl | 17.5 | -60.8 | -60785 | 0.4 | ELF3 ZBTB40 BATF RAD21 ETS1 SCRT2 ZNF143 ZNF654 JUNB ZEB2 | CCSER2 LINC00858 CDHR1 GC10P084248 GC10P084249 GC10M084258 | |
GH10I084293 | Enhancer | 1 | ENCODE | 12.4 | -34.8 | -34756 | 0.2 | PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 FOS | CCSER2 GC10M084258 LINC00858 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CCSER2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CCSER2 Gene
Genomic Locations for CCSER2 Gene
- chr10:84,328,586-84,518,521
- (GRCh38/hg38)
- Size:
- 189,936 bases
- Orientation:
- Plus strand
- chr10:86,088,342-86,278,276
- (GRCh37/hg19)
Genomic View for CCSER2 Gene
Genes around CCSER2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.1 by Ensembl
- 10q23.1 by Entrez Gene
- 10q23.1 by HGNC
CCSER2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for CCSER2 Gene
Proteins for CCSER2 Gene
-
Protein details for CCSER2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H7U1-CCSE2_HUMAN
- Recommended name:
- Serine-rich coiled-coil domain-containing protein 2
- Protein Accession:
- Q9H7U1
- B4DFY4
- B4DQU9
- B7WPE8
- D3DWE2
- Q8N6E9
- Q9H2S0
- Q9ULU1
Protein attributes for CCSER2 Gene
- Size:
- 834 amino acids
- Molecular mass:
- 93548 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAG44473.1; Type=Frameshift; Positions=187, 240, 244; Evidence={ECO:0000305}; Sequence=AAH30528.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI40902.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for CCSER2 Gene
Post-translational modifications for CCSER2 Gene
No Post-translational modifications
Other Protein References for CCSER2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CCSER2
- Invitrogen Antibodies for CCSER2
- Search GeneTex for Antibodies for CCSER2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCSER2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CCSER2
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- Search GeneTex for Proteins for CCSER2
Assay Products
No data available for DME Specific Peptides for CCSER2 Gene
Domains & Families for CCSER2 Gene
Gene Families for CCSER2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for CCSER2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H7U1- Family:
-
- Belongs to the CCSER family.
Function for CCSER2 Gene
Phenotypes From GWAS Catalog for CCSER2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008017 | microtubule binding | IEA | -- |
Phenotypes for CCSER2 Gene
- GenomeRNAi human phenotypes for CCSER2:
Animal Model Products
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ViGene Biosciences lentiviral particle packaged cDNA for CCSER2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for CCSER2
- genomics-online: gRNA clones - Search results for available CCSER2 gene related products
- Applied Biological Materials CRISPR for CCSER2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCSER2
- GenScript: Design CRISPR guide RNA sequences for CCSER2
miRNA for CCSER2 Gene
- miRTarBase miRNAs that target CCSER2
-
- hsa-mir-335-5p (MIRT018535)
- hsa-mir-132-3p (MIRT021844)
- hsa-mir-26b-5p (MIRT029906)
- hsa-mir-20a-5p (MIRT440386)
- hsa-mir-106b-5p (MIRT440387)
- hsa-mir-6516-5p (MIRT479664)
- hsa-mir-455-3p (MIRT479665)
- hsa-mir-6499-3p (MIRT479666)
- hsa-mir-298 (MIRT479667)
- hsa-mir-1827 (MIRT479668)
- hsa-mir-4537 (MIRT479669)
- hsa-mir-5186 (MIRT479670)
- hsa-mir-1247-3p (MIRT479671)
- hsa-mir-6511a-5p (MIRT479672)
- hsa-mir-1910-3p (MIRT479673)
- hsa-mir-495-5p (MIRT479674)
- hsa-mir-6864-3p (MIRT538619)
- hsa-mir-3672 (MIRT538620)
- hsa-mir-4633-5p (MIRT538621)
- hsa-mir-873-3p (MIRT538622)
- hsa-mir-4719 (MIRT538623)
- hsa-mir-532-5p (MIRT538624)
- hsa-mir-3145-5p (MIRT538625)
- hsa-mir-1252-3p (MIRT538626)
- hsa-mir-3662 (MIRT538627)
- hsa-mir-548c-3p (MIRT538628)
- hsa-mir-32-5p (MIRT538629)
- hsa-mir-25-3p (MIRT538630)
- hsa-mir-363-3p (MIRT538631)
- hsa-mir-367-3p (MIRT538632)
- hsa-mir-92a-3p (MIRT538633)
- hsa-mir-92b-3p (MIRT538634)
- hsa-mir-6867-5p (MIRT558876)
- hsa-mir-223-5p (MIRT558877)
- hsa-mir-511-3p (MIRT558878)
- hsa-mir-522-3p (MIRT558879)
- hsa-mir-224-3p (MIRT558880)
- hsa-mir-4482-3p (MIRT650719)
- hsa-mir-676-5p (MIRT650720)
- hsa-mir-138-2-3p (MIRT650722)
- hsa-mir-4786-5p (MIRT704878)
- hsa-mir-6849-3p (MIRT704879)
- hsa-mir-4433a-3p (MIRT704880)
- hsa-mir-4459 (MIRT704881)
- hsa-mir-6500-3p (MIRT704882)
- hsa-mir-3614-5p (MIRT704883)
- hsa-mir-4761-5p (MIRT704884)
- hsa-mir-4293 (MIRT704885)
- hsa-mir-624-3p (MIRT704886)
- hsa-mir-19a-3p (MIRT727359)
- hsa-mir-19b-3p (MIRT727360)
- hsa-mir-519d-3p (MIRT727361)
- hsa-mir-93-5p (MIRT727362)
- hsa-mir-20b-5p (MIRT727363)
- hsa-mir-17-5p (MIRT727364)
- hsa-mir-371a-5p (MIRT742588)
- hsa-mir-371b-5p (MIRT742601)
- hsa-mir-372-5p (MIRT742612)
- hsa-mir-373-5p (MIRT742625)
- hsa-mir-4698 (MIRT747256)
- hsa-mir-513c-5p (MIRT749781)
- hsa-mir-514b-5p (MIRT749787)
- hsa-mir-552-5p (MIRT750890)
- hsa-mir-616-5p (MIRT752528)
- hsa-mir-8063 (MIRT760048)
- hsa-mir-149-3p (MIRT762770)
- hsa-mir-3160-5p (MIRT765157)
- hsa-mir-3175 (MIRT765235)
- hsa-mir-3606-3p (MIRT765848)
- hsa-mir-4267 (MIRT768227)
- hsa-mir-4662a-3p (MIRT770785)
- hsa-mir-4680-5p (MIRT770925)
- hsa-mir-4716-3p (MIRT771419)
- hsa-mir-4723-5p (MIRT771612)
- hsa-mir-4728-5p (MIRT771685)
- hsa-mir-508-5p (MIRT773131)
- hsa-mir-513a-3p (MIRT773383)
- hsa-mir-513c-3p (MIRT773410)
- hsa-mir-5698 (MIRT775138)
- hsa-mir-656-3p (MIRT777315)
- hsa-mir-6785-5p (MIRT779095)
- hsa-mir-6794-5p (MIRT779344)
- hsa-mir-6870-5p (MIRT780688)
- hsa-mir-6878-5p (MIRT780769)
- hsa-mir-6883-5p (MIRT780891)
- hsa-mir-7111-5p (MIRT781443)
- hsa-mir-766-3p (MIRT781838)
miRNA Products
- Search ViGene Biosciences for CCSER2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CCSER2
- Browse OriGene Inhibitory RNA Products For CCSER2
- genomics-online: shRNA clones - Search results for available CCSER2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CCSER2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available CCSER2 gene related products
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- Applied Biological Materials Clones for CCSER2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCSER2
-
ViGene Biosciences adenoviral particle packaged cDNA for CCSER2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCSER2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCSER2 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCSER2 Gene
Localization for CCSER2 Gene
- Cytosol (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015630 | microtubule cytoskeleton | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCSER2 Gene
Pathways & Interactions for CCSER2 Gene
No Data Available
Interacting Proteins for CCSER2 Gene
Selected Interacting proteins:
Q9H7U1-CCSE2_HUMAN
ENSP00000224756
for CCSER2 Gene via
MINT
STRING
IID
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001578 | microtubule bundle formation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CCSER2 Gene
Transcripts for CCSER2 Gene
mRNA/cDNA for CCSER2 Gene
- (20) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (135) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCSER2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCSER2
- genomics-online: gRNA clones - Search results for available CCSER2 gene related products
- Applied Biological Materials CRISPR for CCSER2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCSER2
- GenScript: Design CRISPR guide RNA sequences for CCSER2
miRNA Products
- Search ViGene Biosciences for CCSER2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CCSER2
- Browse OriGene Inhibitory RNA Products For CCSER2
- genomics-online: shRNA clones - Search results for available CCSER2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CCSER2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available CCSER2 gene related products
- orf clones - Search results for available CCSER2 gene related products
- Applied Biological Materials Clones for CCSER2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||
SP5: |
Expression for CCSER2 Gene
This gene is overexpressed in Tlymphocyte (28.1), Heart (27.2), and Urinary Bladder (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCSER2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CCSER2 Gene:
CCSER2SOURCE GeneReport for Unigene cluster for CCSER2 Gene:
Hs.461988Evidence on tissue expression from TISSUES for CCSER2 Gene
- Nervous system(4.7)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CCSER2
-
OriGene qPCR primer pairs for CCSER2
- genomics-online: primer clones - Search results for available CCSER2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCSER2 Gene
Orthologs for CCSER2 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | KIAA1128 33 |
|
||
CCSER2 34 |
|
OneToOne | |||
dog (Canis familiaris) |
Mammalia | FAM190B 33 |
|
||
CCSER2 34 |
|
OneToOne | |||
cow (Bos Taurus) |
Mammalia | FAM190B 33 |
|
||
CCSER2 34 |
|
OneToOne | |||
rat (Rattus norvegicus) |
Mammalia | Ccser2 33 |
|
||
mouse (Mus musculus) |
Mammalia | Ccser2 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | CCSER2 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | CCSER2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | FAM190B 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | CCSER2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.17140 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | CCSER2 (1 of 2) 34 |
|
OneToMany | |
ccser2 34 |
|
OneToMany |
- Species where no ortholog for CCSER2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CCSER2 Gene
Pseudogenes.org Pseudogenes for CCSER2 Gene
No data available for Paralogs for CCSER2 Gene
Variants for CCSER2 Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000001388 | -- | 84,447,892(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs1000008943 | -- | 84,427,706(+) | C/G | genic_downstream_transcript_variant, intron_variant | |
rs1000032662 | -- | 84,343,724(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
rs1000044661 | -- | 84,516,328(+) | C/G | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
rs1000055821 | -- | 84,426,443(+) | G/T | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.34;
63.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCSER2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCSER2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCSER2 Gene
Disorders for CCSER2 Gene
Additional Disease Information for CCSER2
No disorders were found for CCSER2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCSER2 Gene
Publications for CCSER2 Gene
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
Products for CCSER2 Gene
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- Invitrogen Antibodies for CCSER2
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- antibodies-online: Search results for available CCSER2 related products ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for CCSER2 gene
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Sources for CCSER2 Gene
- (1) GeneCards
- (2) HGNC
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