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Aliases for CCSER2 Gene

Aliases for CCSER2 Gene

  • Coiled-Coil Serine Rich Protein 2 2 3 5
  • KIAA1128 2 3 4
  • Family With Sequence Similarity 190, Member B 2 3
  • Coiled-Coil Serine-Rich Protein 2 2 4
  • Protein GCAP14 Homolog 3 4
  • FAM190B 3 4
  • Serine-Rich Coiled-Coil Domain-Containing Protein 2 3
  • Protein FAM190B 3
  • BA486O22.1 3
  • Gcap14 3

External Ids for CCSER2 Gene

Previous HGNC Symbols for CCSER2 Gene

  • KIAA1128
  • FAM190B

Previous GeneCards Identifiers for CCSER2 Gene

  • GC10P086088

Summaries for CCSER2 Gene

GeneCards Summary for CCSER2 Gene

CCSER2 (Coiled-Coil Serine Rich Protein 2) is a Protein Coding gene. GO annotations related to this gene include microtubule binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCSER2 Gene

Genomics for CCSER2 Gene

Regulatory Elements for CCSER2 Gene

Enhancers for CCSER2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F084327 1.5 FANTOM5 ENCODE 18.8 +1.1 1085 5.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YY1 ZNF207 FOS KLF13 CCSER2 RPL12P29
GH10F084293 1.3 Ensembl ENCODE 12.4 -34.8 -34786 0.4 PKNOX1 ATF1 ARNT CBX5 ELK1 GATA2 FOS KLF13 ZNF263 JUNB CCSER2 GC10M084258 LINC00858
GH10F084360 0.8 Ensembl ENCODE 19.7 +33.0 33015 2.0 ZNF837 ZNF416 ZBTB33 FOS YBX1 IRF1 FOXA1 CCSER2 RPL12P29
GH10F084333 1.1 Ensembl ENCODE 12.9 +7.1 7093 5.0 PKNOX1 SIN3A FEZF1 SCRT2 FOS ZNF263 ZNF362 NFYA OVOL3 ZNF843 CCSER2 RPL12P29
GH10F084267 0.8 Ensembl 17.4 -60.8 -60786 0.4 ELF3 CTCF TFAP4 TBL1XR1 ETV1 TEAD4 RAD21 ETS1 TEAD3 SCRT2 CCSER2 LINC00858 CDHR1 GC10P084248 GC10P084249
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCSER2 on UCSC Golden Path with GeneCards custom track

Promoters for CCSER2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000116795 814 2401 HDGF PKNOX1 ATF1 ARNT CREB3L1 ARID4B SIN3A YY1 ZNF121 ZNF207

Genomic Location for CCSER2 Gene

Chromosome:
10
Start:
84,328,586 bp from pter
End:
84,518,521 bp from pter
Size:
189,936 bases
Orientation:
Plus strand

Genomic View for CCSER2 Gene

Genes around CCSER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCSER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCSER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCSER2 Gene

Proteins for CCSER2 Gene

  • Protein details for CCSER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7U1-CCSE2_HUMAN
    Recommended name:
    Serine-rich coiled-coil domain-containing protein 2
    Protein Accession:
    Q9H7U1
    Secondary Accessions:
    • B4DFY4
    • B4DQU9
    • B7WPE8
    • D3DWE2
    • Q8N6E9
    • Q9H2S0
    • Q9ULU1

    Protein attributes for CCSER2 Gene

    Size:
    834 amino acids
    Molecular mass:
    93548 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG44473.1; Type=Frameshift; Positions=187, 240, 244; Evidence={ECO:0000305}; Sequence=AAH30528.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI40902.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CCSER2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCSER2 Gene

Post-translational modifications for CCSER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCSER2 Gene

Domains & Families for CCSER2 Gene

Protein Domains for CCSER2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCSER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7U1

UniProtKB/Swiss-Prot:

CCSE2_HUMAN :
  • Belongs to the CCSER family.
Family:
  • Belongs to the CCSER family.
genes like me logo Genes that share domains with CCSER2: view

No data available for Gene Families for CCSER2 Gene

Function for CCSER2 Gene

Gene Ontology (GO) - Molecular Function for CCSER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with CCSER2: view
genes like me logo Genes that share phenotypes with CCSER2: view

Animal Model Products

miRNA for CCSER2 Gene

miRTarBase miRNAs that target CCSER2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCSER2 Gene

Localization for CCSER2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCSER2 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for CCSER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCSER2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCSER2 Gene

Pathways & Interactions for CCSER2 Gene

SuperPathways for CCSER2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCSER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IEA --
genes like me logo Genes that share ontologies with CCSER2: view

No data available for Pathways by source and SIGNOR curated interactions for CCSER2 Gene

Transcripts for CCSER2 Gene

Unigene Clusters for CCSER2 Gene

Coiled-coil serine-rich protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCSER2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for CCSER2 Gene

GeneLoc Exon Structure for
CCSER2
ECgene alternative splicing isoforms for
CCSER2

Expression for CCSER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCSER2 Gene

Protein differential expression in normal tissues from HIPED for CCSER2 Gene

This gene is overexpressed in Tlymphocyte (28.1), Heart (27.2), and Urinary Bladder (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCSER2 Gene



Protein tissue co-expression partners for CCSER2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCSER2 Gene:

CCSER2

SOURCE GeneReport for Unigene cluster for CCSER2 Gene:

Hs.461988
genes like me logo Genes that share expression patterns with CCSER2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCSER2 Gene

Orthologs for CCSER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCSER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1128 34
  • 99.59 (n)
CCSER2 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM190B 34
  • 91.48 (n)
CCSER2 35
  • 27 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM190B 34
  • 90.96 (n)
CCSER2 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccser2 34
  • 85.2 (n)
mouse
(Mus musculus)
Mammalia Ccser2 34 16 35
  • 84.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCSER2 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCSER2 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM190B 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCSER2 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17140 34
zebrafish
(Danio rerio)
Actinopterygii CCSER2 (1 of 2) 35
  • 35 (a)
OneToMany
ccser2 35
  • 27 (a)
OneToMany
Species where no ortholog for CCSER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCSER2 Gene

ENSEMBL:
Gene Tree for CCSER2 (if available)
TreeFam:
Gene Tree for CCSER2 (if available)

Paralogs for CCSER2 Gene

Pseudogenes.org Pseudogenes for CCSER2 Gene

genes like me logo Genes that share paralogs with CCSER2: view

No data available for Paralogs for CCSER2 Gene

Variants for CCSER2 Gene

Sequence variations from dbSNP and Humsavar for CCSER2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10082464 -- 84,397,004(+) TTGTA(A/C)TTTAG intron-variant
rs10082518 -- 84,330,613(+) GTTCA(C/T)GCGAT intron-variant
rs10430707 -- 84,416,885(+) GAGAT(C/T)GCGCC intron-variant
rs10491033 -- 84,426,485(+) AAACC(A/G)TCTCT intron-variant
rs1050943 -- 84,517,200(+) ACATT(C/T)GTGAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCSER2 Gene

Variant ID Type Subtype PubMed ID
nsv522443 CNV gain 19592680
nsv551745 CNV gain 21841781
nsv551754 CNV loss 21841781
nsv831932 CNV loss 17160897
nsv948107 CNV duplication 23825009
nsv1141879 OTHER inversion 24896259
nsv1046749 CNV gain 25217958
esv3624031 CNV loss 21293372

Variation tolerance for CCSER2 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCSER2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCSER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCSER2 Gene

Disorders for CCSER2 Gene

Relevant External Links for CCSER2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCSER2

No disorders were found for CCSER2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCSER2 Gene

Publications for CCSER2 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3 64

Products for CCSER2 Gene

Sources for CCSER2 Gene

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