CCSAP Gene
protein-coding GIFtS: 35
GCID: GC01M229457
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centriole, cilia and spindle-associated protein(Previous name: chromosome 1 open reading frame 96 )
(Previous symbol: C1orf96)
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Aliases
for CCSAP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centriole, Cilia And Spindle-Associated Protein1 2 | | C1orf961 2 3 | | CSAP1 2 3 | | FLJ414711 | | Chromosome 1 Open Reading Frame 961 | | Centriole And Spindle-Associated Protein2 |
Export aliases for CCSAP gene to outside databases |
Summaries
for CCSAP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CCSAP_HUMAN, Q6IQ19Function: May play a role in embryonic development. May be required for proper cilia beating (By similarity)
|
Genomic Views
for CCSAP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CCSAP
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCSAP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCSAP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42.13CCSAP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M229457: view genomic region
(about GC identifiers)
Start:
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229,456,752 bp from pter |
End:
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229,479,041 bp from pter |
Size:
|
22,290 bases |
Orientation:
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minus strand |
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Proteins
for CCSAP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCSAP_HUMAN, Q6IQ19 (See
protein sequence)Recommended Name: Centriole, cilia and spindle-associated protein Size: 270 amino acids; 30216 Da
Subunit: Associates with microtubules; the association occurs on polyglutamylated tubulin
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Cytoplasm,cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection,axon. Cell projection, cilium. Note=Localizes to two to four centrioles throughout the cell cycle. Localizes tomitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton oninterphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules.Colocalizes with polyglutamylated tubulin
Secondary accessions: A8K5X2 Q6P9G2 Q6ZW85 Q8IXU1 Q96BM2Alternative splicing: 4 isoforms: Q6IQ19-1 Q6IQ19-2 Q6IQ19-3 Q6IQ19-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCSAP: NX_Q6IQ19
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IQ19
CCSAP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660300.3
ENSEMBL proteins: ENSP00000355648 ENSP00000355647 ENSP00000284617 ENSP00000392927
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
CCSAP for ontologies About GeneDecksing
CCSAP Antibody Products:
Assay Products for CCSAP: |
Protein
Domains /
Families
for CCSAP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6IQ19 UniProtKB/Swiss-Prot: CCSAP_HUMAN, Q6IQ19Similarity: Belongs to the CCSAP family |
Function
for CCSAP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CCSAP_HUMAN, Q6IQ19Function: May play a role in embryonic development. May be required for proper cilia beating (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCSAP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCSAP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CCSAP | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCSAP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCSAP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCSAP |
1 GenomeRNAi human phenotype for CCSAP:
|
Pathways & Interactions
for CCSAP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCSAP
2 Interacting proteins for CCSAP (Q6IQ193) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0045995 | regulation of embryonic development |
ISS | -- | | GO:0060296 | regulation of cilium beat frequency involved in ciliary motility |
ISS | -- |
CCSAP for ontologies About GeneDecksing
|
Drugs & Compounds
for CCSAP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCSAP
Search CenterWatch for drugs/clinical trials and news about CCSAP
|
Transcripts
for CCSAP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCSAP gene: NM_145257.3 Unigene Cluster for CCSAP: Centriole, cilia and spindle-associated protein Hs.585011 [show with all ESTs]Unigene Representative Sequence: BC0716095 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366687 ENST00000366686 ENST00000483092 ENST00000284617(uc001htl.4 uc009xfc.3)
ENST00000452552
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCSAP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCSAP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CCSAP | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCSAP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCSAP |
Additional cDNA sequence: AK094615.1 AK098801.1 AK123465.1 AK291437.1 BC015419.1 BC039241.1 BC060777.1 BC071609.1 9 DOTS entries: DT.75183322 DT.40219159 DT.100829980 DT.100020404 DT.99938889 DT.113151 DT.75122112 DT.100814503 DT.95158468 24/144 AceView cDNA sequences (see all 144): BM787647 T10547 AA399134 BX366013 BX419008 BC015419 BU155676 BQ445918 N41054 BM470687 BE018674 BE302244 AK094615 AA294830 BX423096 BQ423730 N47141 BU739635 BC060777 F04270 F11109 BC039241 Z41040 AW014856
GeneLoc Exon Structure
|
Expression
for CCSAP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See CCSAP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCSAP
SOURCE GeneReport for Unigene cluster: Hs.585011
SABiosciences Custom PCR Arrays for CCSAP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCSAP
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CCSAP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCSAP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCSAP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCSAP |
Orthologs
for CCSAP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCSAP gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ccsap1 , 5 |
RIKEN cDNA 1700054N08 gene5
centriole, cilia and spindle associated protein1 |
77.78(n)1
74.6(a)1 |
|
8 (72.22 cM)5
734201 NM_028536.11 NP_082812.11
1238408315 |
chicken
(Gallus gallus) |
Aves |
C3H1orf961 |
chromosome 3 open reading frame, human C1orf96 |
61.9(n)
59.01(a) |
|
421533 XM_419574.3 XP_419574.3 |
lizard
(Anolis carolinensis) |
Reptilia |
C1orf966 |
-- |
49(a) |
1 ↔ 1 |
1(222148132-222174973) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.290932 |
Danio rerio cDNA clone IMAGE6997555, partial cds |
74.4(n) |
|
BC063997.1 |
ENSEMBL Gene Tree for CCSAP (if available)
TreeFam Gene Tree for CCSAP (if available) |
Paralogs
for CCSAP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCSAP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCSAP (229456752 - 229479041 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCSAP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCSAP |
|
Disorders
/ Diseases
for CCSAP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CCSAP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCSAP gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCSAP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. (PubMed id 22493317)1, 2, 3 Backer C.B.... Cheeseman I.M. (2012)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CCSAP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCSAP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCSAP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCSAP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCSAP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCSAP gene:
Search GeneIP for patents involving CCSAP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCSAP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCSAP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCSAP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCSAP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCSAP | | OriGene 3'-UTR Clone for CCSAP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCSAP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCSAP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCSAP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCSAP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCSAP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCSAP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCSAP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCSAP |
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 |  |  |  | |
| | | | Search Tocris compounds for CCSAP |
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 | | | CCSAP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCSAP |
|  |  |  | | | | Search ThermoFisher Antibodies for CCSAP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCSAP |
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