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Aliases for CCSAP Gene

Aliases for CCSAP Gene

  • Centriole, Cilia And Spindle-Associated Protein 2 3
  • Centriole And Spindle-Associated Protein 2 3
  • C1orf96 3 4
  • CSAP 3 4
  • Chromosome 1 Open Reading Frame 96 2

External Ids for CCSAP Gene

Previous Symbols for CCSAP Gene

  • C1orf96

Summaries for CCSAP Gene

GeneCards Summary for CCSAP Gene

CCSAP (Centriole, Cilia And Spindle-Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCSAP Gene

  • May play a role in embryonic development. May be required for proper cilia beating (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCSAP Gene

Genomics for CCSAP Gene

Genomic Location for CCSAP Gene

Start:
229,321,005 bp from pter
End:
229,343,294 bp from pter
Size:
22,290 bases
Orientation:
Minus strand

Genomic View for CCSAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCSAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCSAP Gene

No data available for Regulatory Elements for CCSAP Gene

Proteins for CCSAP Gene

  • Protein details for CCSAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ19-CCSAP_HUMAN
    Recommended name:
    Centriole, cilia and spindle-associated protein
    Protein Accession:
    Q6IQ19
    Secondary Accessions:
    • A8K5X2
    • Q6P9G2
    • Q6ZW85
    • Q8IXU1
    • Q96BM2

    Protein attributes for CCSAP Gene

    Size:
    270 amino acids
    Molecular mass:
    30216 Da
    Quaternary structure:
    • Associates with microtubules; the association occurs on polyglutamylated tubulin

    Alternative splice isoforms for CCSAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCSAP Gene

Proteomics data for CCSAP Gene at MOPED

Post-translational modifications for CCSAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCSAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCSAP Gene

Domains for CCSAP Gene

Protein Domains for CCSAP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6IQ19

UniProtKB/Swiss-Prot:

CCSAP_HUMAN
Family:
  • Belongs to the CCSAP family.:
    • Q6IQ19
genes like me logo Genes that share domains with CCSAP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CCSAP Gene

Function for CCSAP Gene

Molecular function for CCSAP Gene

UniProtKB/Swiss-Prot Function: May play a role in embryonic development. May be required for proper cilia beating (By similarity).

Phenotypes for CCSAP Gene

GenomeRNAi human phenotypes for CCSAP:
genes like me logo Genes that share phenotypes with CCSAP: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCSAP Gene

Localization for CCSAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCSAP Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, axon. Cell projection, cilium. Note=Localizes to two to four centrioles throughout the cell cycle. Localizes to mitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton on interphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules. Colocalizes with polyglutamylated tubulin.

Gene Ontology (GO) - Cellular Components for CCSAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IDA 22493317
GO:0005819 spindle IDA 22493317
GO:0005929 cilium IDA 22493317
GO:0005930 axoneme IDA 22493317
genes like me logo Genes that share ontologies with CCSAP: view

No data available for Subcellular locations from COMPARTMENTS for CCSAP Gene

Pathways for CCSAP Gene

SuperPathways for CCSAP Gene

No Data Available

Interacting Proteins for CCSAP Gene

Selected Interacting proteins: Q6IQ19-CCSAP_HUMAN for CCSAP Gene via I2D

Symbol External ID(s) Details
KCNMA1
YWHAB

Gene Ontology (GO) - Biological Process for CCSAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0045995 regulation of embryonic development ISS --
GO:0060296 regulation of cilium beat frequency involved in ciliary motility ISS --
genes like me logo Genes that share ontologies with CCSAP: view

No data available for Pathways by source for CCSAP Gene

Transcripts for CCSAP Gene

Unigene Clusters for CCSAP Gene

Centriole, cilia and spindle-associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCSAP Gene

No ASD Table

Relevant External Links for CCSAP Gene

GeneLoc Exon Structure for
CCSAP
ECgene alternative splicing isoforms for
CCSAP

Expression for CCSAP Gene

mRNA expression in normal human tissues for CCSAP Gene

mRNA differential expression in normal tissues according to GTEx for CCSAP Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.0) and Brain - Cerebellum (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCSAP Gene

SOURCE GeneReport for Unigene cluster for CCSAP Gene Hs.585011

genes like me logo Genes that share expressions with CCSAP: view

No data available for mRNA Expression by UniProt/SwissProt for CCSAP Gene

Orthologs for CCSAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCSAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCSAP 35
  • 96.91 (n)
  • 95.93 (a)
CCSAP 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCSAP 35
  • 82.64 (n)
  • 77.95 (a)
CCSAP 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCSAP 35
  • 87.69 (n)
  • 80.97 (a)
CCSAP 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccsap 35
  • 76.06 (n)
  • 71.03 (a)
Ccsap 16
Ccsap 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCSAP 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccsap 35
  • 76.85 (n)
  • 71.83 (a)
chicken
(Gallus gallus)
Aves C1ORF96 35
  • 68.56 (n)
  • 65.25 (a)
CCSAP 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCSAP 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCSAP (1 of 2) 36
  • 26 (a)
OneToMany
ccsapb 35
  • 47.2 (n)
  • 44.4 (a)
ccsapb 36
  • 40 (a)
OneToMany
Dr.29093 35
Species with no ortholog for CCSAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCSAP Gene

ENSEMBL:
Gene Tree for CCSAP (if available)
TreeFam:
Gene Tree for CCSAP (if available)

Paralogs for CCSAP Gene

No data available for Paralogs for CCSAP Gene

Variants for CCSAP Gene

Sequence variations from dbSNP and Humsavar for CCSAP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1088 -- 229,322,709(+) CTCCC(A/C/G/T)CGGAC utr-variant-3-prime
rs149158 -- 229,330,834(+) CATCT(A/C)AAAAA intron-variant
rs151461 -- 229,333,259(+) aaccc(C/T)gtctc intron-variant
rs151470 -- 229,332,283(+) ggcct(C/G)gactt intron-variant
rs151471 -- 229,332,858(+) acaga(C/G)agagc intron-variant

Relevant External Links for CCSAP Gene

HapMap Linkage Disequilibrium report
CCSAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCSAP Gene

Disorders for CCSAP Gene

No disorders were found for CCSAP Gene.

No data available for UniProtKB/Swiss-Prot for CCSAP Gene

Publications for CCSAP Gene

  1. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. (PMID: 22493317) Backer C.B. … Cheeseman I.M. (Mol. Biol. Cell 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for CCSAP Gene

Sources for CCSAP Gene

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