Aliases for CCS Gene
Aliases for CCS Gene
External Ids for CCS Gene
- HGNC: 1613
- Entrez Gene: 9973
- Ensembl: ENSG00000173992
- OMIM: 603864
- UniProtKB: O14618
Previous GeneCards Identifiers for CCS Gene
- GC11P068894
- GC11P068043
- GC11P066610
- GC11P066136
- GC11P066117
- GC11P066360
- GC11P062688
Summaries for CCS Gene
-
Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCS Gene
CCS (Copper Chaperone For Superoxide Dismutase) is a Protein Coding gene. Diseases associated with CCS include Entropion and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Copper homeostasis and Cellular Senescence. GO annotations related to this gene include copper ion binding and copper ion transmembrane transporter activity. An important paralog of this gene is SOD1.
UniProtKB/Swiss-Prot for CCS Gene
-
Delivers copper to copper zinc superoxide dismutase (SOD1).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCS Gene
Genomics for CCS Gene
Regulatory Elements for CCS Gene
- Transcription factor binding sites by QIAGEN in the CCS gene promoter:
Regulatory Element Products
Genomic Location for CCS Gene
- Chromosome:
- 11
- Start:
- 66,592,821 bp from pter
- End:
- 66,606,019 bp from pter
- Size:
- 13,199 bases
- Orientation:
- Plus strand
Genomic View for CCS Gene
Genes around CCS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.2 by Ensembl
- 11q13.2 by Entrez Gene
- 11q13.2 by HGNC
CCS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCS Gene
Proteins for CCS Gene
-
Protein details for CCS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14618-CCS_HUMAN
- Recommended name:
- Copper chaperone for superoxide dismutase
- Protein Accession:
- O14618
- Q2M366
- Q8NEV0
Protein attributes for CCS Gene
- Size:
- 274 amino acids
- Molecular mass:
- 29041 Da
- Cofactor:
- Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4.
Protein Expression for CCS Gene
Post-translational modifications for CCS Gene
- Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.
- Ubiquitination at posLast=7676, Lys189, posLast=216216, and Lys241
- Modification sites at PhosphoSitePlus
Other Protein References for CCS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCS
- Novus Biologicals Antibodies for CCS
-
Abcam antibodies for CCS
-
Cloud-Clone Corp. Antibodies for CCS
- Invitrogen Antibodies for CCS
- antibodies-online Antibodies for CCS: See all 55
- Search GeneTex for Antibodies for CCS
Protein Products
-
OriGene Purified Proteins for CCS
- Search Origene for MassSpec and Protein Over-expression Lysates for CCS
- Origene Custom Protein Services for CCS
- ProSpec Recombinant Proteins for CCS
-
Cloud-Clone Corp. Proteins for CCS
- antibodies-online Proteins for CCS: See all 17
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CCS
-
Abcam proteins for CCS
No data available for DME Specific Peptides for CCS Gene
Domains & Families for CCS Gene
Protein Domains for CCS Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14618UniProtKB/Swiss-Prot:
CCS_HUMAN :- In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
- Family:
-
- In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
No data available for Gene Families for CCS Gene
Function for CCS Gene
Molecular function for CCS Gene
- GENATLAS Biochemistry:
- copper chaperone for superoxide dismutase,S cerevisiae LYS7 ortholog
- UniProtKB/Swiss-Prot Function:
- Delivers copper to copper zinc superoxide dismutase (SOD1).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004784 | superoxide dismutase activity | IEA,IBA | -- |
| GO:0005507 | copper ion binding | IDA | 9726962 |
| GO:0005515 | protein binding | IPI | 9726962 |
| GO:0008270 | zinc ion binding | IBA | -- |
| GO:0015035 | protein disulfide oxidoreductase activity | TAS | -- |
Phenotypes for CCS Gene
- MGI mutant phenotypes for CCS:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CCS:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Dynamic nuclei (hole, folded or small irregular)
- Resistant to vaccinia virus (VACV-A4L) infection
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cilium length after serum starvation
Animal Models for CCS Gene
- MGI Knock Outs for CCS:
-
- Ccs tm1Pcw
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCS
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCS gene
- Search ViGene Biosciences for CCS
CRISPR Products
-
OriGene CRISPR knockouts for CCS
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCS
- GenScript: Design CRISPR guide RNA sequences for CCS
miRNA for CCS Gene
- miRTarBase miRNAs that target CCS
-
- ath-mir398a-3p (MIRT005464)
- ath-mir398b-3p (MIRT005465)
- ath-mir398c-3p (MIRT005466)
- hsa-mir-484 (MIRT042263)
- hsa-mir-5698 (MIRT617435)
- hsa-mir-744-3p (MIRT617436)
- hsa-mir-4423-5p (MIRT617437)
- hsa-mir-6501-5p (MIRT617438)
- hsa-mir-891a-3p (MIRT617439)
- hsa-mir-143-5p (MIRT617440)
- hsa-mir-4430 (MIRT617441)
- hsa-mir-3652 (MIRT617442)
- hsa-mir-593-5p (MIRT617443)
- hsa-mir-122-5p (MIRT617444)
- hsa-mir-504-3p (MIRT617445)
- hsa-mir-3135b (MIRT617446)
- hsa-mir-6499-3p (MIRT617447)
- hsa-mir-767-5p (MIRT617448)
- hsa-mir-367-5p (MIRT617449)
- hsa-mir-1267 (MIRT617450)
- hsa-mir-4638-5p (MIRT617451)
- hsa-mir-1307-3p (MIRT617452)
- hsa-mir-6741-3p (MIRT617453)
- hsa-mir-5693 (MIRT617454)
- hsa-mir-1303 (MIRT617455)
- hsa-mir-5096 (MIRT617456)
- hsa-mir-6802-3p (MIRT617457)
- hsa-mir-411-5p (MIRT617458)
- hsa-mir-4662a-5p (MIRT617459)
- hsa-mir-6832-5p (MIRT617460)
- hsa-mir-193b-5p (MIRT617461)
- hsa-mir-3620-3p (MIRT617462)
- hsa-mir-6865-3p (MIRT617463)
- hsa-mir-575 (MIRT617464)
- hsa-mir-4676-5p (MIRT617465)
- hsa-mir-6858-3p (MIRT617466)
- hsa-mir-483-5p (MIRT617467)
- hsa-mir-10b-5p (MIRT617468)
- hsa-mir-10a-5p (MIRT617469)
- hsa-mir-129-5p (MIRT625164)
- hsa-mir-372-5p (MIRT625165)
- hsa-mir-371a-5p (MIRT625166)
- hsa-mir-616-5p (MIRT625167)
- hsa-mir-373-5p (MIRT625168)
- hsa-mir-371b-5p (MIRT625169)
- hsa-mir-3613-3p (MIRT625170)
- hsa-mir-4282 (MIRT625171)
- hsa-mir-3149 (MIRT642899)
- hsa-mir-7850-5p (MIRT661456)
- hsa-mir-620 (MIRT661457)
- hsa-mir-1270 (MIRT661458)
- hsa-mir-4531 (MIRT661459)
- hsa-mir-6812-3p (MIRT671243)
- hsa-mir-4284 (MIRT672737)
- hsa-mir-2276-3p (MIRT672738)
- hsa-mir-365b-5p (MIRT678034)
- hsa-mir-365a-5p (MIRT678035)
- hsa-mir-8052 (MIRT678036)
- hsa-mir-3199 (MIRT678037)
- hsa-mir-150-5p (MIRT678038)
- hsa-mir-6814-5p (MIRT678039)
- hsa-mir-122-3p (MIRT678040)
- hsa-mir-582-3p (MIRT678041)
- hsa-mir-5089-5p (MIRT683461)
- hsa-mir-6807-5p (MIRT683462)
- hsa-mir-7151-3p (MIRT683463)
- hsa-mir-5095 (MIRT683464)
- hsa-mir-5589-5p (MIRT683465)
- hsa-mir-4731-5p (MIRT683466)
- hsa-mir-6506-5p (MIRT683467)
- hsa-mir-619-5p (MIRT683468)
- hsa-mir-1292-3p (MIRT683469)
- hsa-mir-6504-3p (MIRT683470)
- hsa-mir-512-3p (MIRT683471)
- hsa-mir-4438 (MIRT683472)
- hsa-mir-597-5p (MIRT706597)
- hsa-mir-6778-3p (MIRT706598)
- hsa-mir-6747-3p (MIRT706599)
- hsa-mir-4740-3p (MIRT706600)
- hsa-mir-6715b-5p (MIRT706601)
- hsa-mir-4269 (MIRT706602)
- hsa-mir-3622a-5p (MIRT706603)
miRNA Products
- Search ViGene Biosciences for CCS
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCS
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-
ViGene Biosciences ready-to-package AAV shRNAs for CCS gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for CCS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCS
-
ViGene Biosciences adenoviral particle packaged cDNA for CCS gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCS gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCS Gene
Localization for CCS Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCS Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 9726962 |
| GO:0005737 | cytoplasm | IEA,IDA | 9726962 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for CCS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Amyotrophic lateral sclerosis (ALS) | ||
| 2 | Cellular Senescence | ||
| 3 | Detoxification of Reactive Oxygen Species | ||
| 4 | Copper homeostasis | ||
Pathways by source for CCS Gene
2 BioSystems pathways for CCS Gene
2 Reactome pathways for CCS Gene
1 KEGG pathway for CCS Gene
Interacting Proteins for CCS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006801 | superoxide metabolic process | TAS,IEA | 9295278 |
| GO:0015680 | intracellular copper ion transport | TAS | 9726962 |
| GO:0019430 | removal of superoxide radicals | IBA,IEA | -- |
| GO:0030001 | metal ion transport | IEA | -- |
| GO:0034599 | cellular response to oxidative stress | TAS | -- |
No data available for SIGNOR curated interactions for CCS Gene
Transcripts for CCS Gene
mRNA/cDNA for CCS Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (217) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCS Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCS
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCS
- GenScript: Design CRISPR guide RNA sequences for CCS
miRNA Products
- Search ViGene Biosciences for CCS
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCS
- Browse OriGene Inhibitory RNA Products For CCS
-
ViGene Biosciences ready-to-package AAV shRNAs for CCS gene
Clone Products
- Sino Biological Human cDNA Clone for CCS
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for CCS Gene
This gene is overexpressed in Peripheral blood mononuclear cells (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCS Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CCS Gene:
CCSSOURCE GeneReport for Unigene cluster for CCS Gene:
Hs.502917mRNA Expression by UniProt/SwissProt for CCS Gene:
O14618-CCS_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for CCS Gene
- Nervous system(4.6)
- Liver(4.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for CCS
-
OriGene qPCR primer pairs for CCS
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCS Gene
Orthologs for CCS Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCS 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CCS 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CCS 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccs 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccs 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCS 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CCS 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccs 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ccs 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5828 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CCS 36 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007026 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | sod-5 35 |
|
OneToMany | |
| sod-1 35 |
|
OneToMany | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F26917g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SOD1 35 |
|
OneToMany | |
| CCS1 34 37 |
|
||||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | CCS 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0573200 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU07851 34 |
|
- Species where no ortholog for CCS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CCS Gene
(1) SIMAP similar genes for CCS Gene using alignment to 5 proteins:
Variants for CCS Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs142340643 | Uncertain significance | 66,600,547(+) | CTGAC(C/T)GGGTA | nc-transcript-variant, reference, missense | |
| rs1000310726 | -- | 66,596,825(+) | CAAGG(A/G)GTGTG | intron-variant | |
| rs1000727023 | -- | 66,594,179(+) | CAGTT(A/G)AATCC | intron-variant, upstream-variant-2KB | |
| rs1001785724 | -- | 66,601,782(+) | TTCCT(C/T)AGGCT | intron-variant | |
| rs1001857744 | -- | 66,603,630(+) | TCACA(A/G)GGTCA | intron-variant |
Residual Variation Intolerance Score:
44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.09;
38.26% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCS Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCS Gene
Disorders for CCS Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| entropion |
|
|
| amyotrophic lateral sclerosis 1 |
|
Search CCS in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CCS
No data available for UniProtKB/Swiss-Prot and Genatlas for CCS Gene
Publications for CCS Gene
- Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination. (PMID: 20154138) Brady G.F. … Duckett C.S. (Mol. Cell. Biol. 2010) 3 4 22 64
- Cysteine-to-serine mutants of the human copper chaperone for superoxide dismutase reveal a copper cluster at a domain III dimer interface. (PMID: 15736924) Stasser J.P. … Blackburn N.J. (Biochemistry 2005) 3 4 22 64
- The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase. (PMID: 9726962) Casareno R.L.B. … Gitlin J.D. (J. Biol. Chem. 1998) 3 4 22 64
- The copper chaperone for superoxide dismutase. (PMID: 9295278) Culotta V.C. … Gitlin J.D. (J. Biol. Chem. 1997) 2 3 4 64
- Molecular and biochemical characterization of a unique mutation in CCS, the human copper chaperone to superoxide dismutase. (PMID: 22508683) Huppke P. … Gartner J. (Hum. Mutat. 2012) 3 4 64
Products for CCS Gene
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- antibodies-online Antibodies for CCS: See all 55
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- Horizon Cell Lines for CCS
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCS
- VectorBuilder custom plasmid, inducible vectors for CCS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCS
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer