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Set Analyses:

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CCS Gene

protein-coding GIFtS: 66
GCID: GC11P066360

Copper Chaperone For Superoxide Dismutase

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Copper Chaperone For Superoxide Dismutase¹ ²
Superoxide Dismutase Copper Chaperone² ³

External Ids:	HGNC: 1613¹	Entrez Gene: 9973²	Ensembl: ENSG00000173992⁷	OMIM: 603864⁵	UniProtKB: O14618³

Export aliases for CCS gene to outside databases

Previous GC identifers: GC11P068894 GC11P068043 GC11P066610 GC11P066136 GC11P066117 GC11P062688

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCS Gene:

Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may

activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. (provided by RefSeq, Jul

2008)

GeneCards Summary for CCS Gene:

CCS (copper chaperone for superoxide dismutase) is a protein-coding gene. Diseases associated with CCS include apical myocardial infarction, and hemopericardium. GO annotations related to this gene include copper ion transmembrane transporter activity and copper ion binding. An important paralog of this gene is SOD1.

UniProtKB/Swiss-Prot: CCS_HUMAN, O14618

Function: Delivers copper to copper zinc superoxide dismutase (SOD1)

Gene Wiki entry for CCS Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000011.10 NT_167190.2 NC_018922.2

Regulatory elements:

Regulatory transcription factor binding sites in the CCS gene promoter:
c-Fos C/EBPbeta GATA-3 GATA-2 GATA-1 CREB PPAR-gamma1 deltaCREB c-Myb PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCS promoter sequence

Search Chromatin IP Primers for CCS

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.2

CCS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCS gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P066360: view genomic region (about GC identifiers)

Start:	66,360,292 bp from pter	End:	66,373,490 bp from pter
Size:	13,199 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCS_HUMAN, O14618 (See protein sequence)

Recommended Name: Copper chaperone for superoxide dismutase

Size: 274 amino acids; 29041 Da

Cofactor: Binds 2 copper ions per subunit

Cofactor: Binds 1 zinc ion per subunit

Subunit: Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4

3 PDB 3D structures from and Proteopedia for CCS:

1DO5 (3D)

2CRL (3D)

2RSQ (3D)

Secondary accessions: Q2M366

Explore the universe of human proteins at neXtProt for CCS: NX_O14618

Explore proteomics data for CCS at MOPED

Post-translational modifications:

Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1,

rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241¹

Ubiquitination² at Lys76, Lys189, Lys216, Lys241

Modification sites at PhosphoSitePlus

See CCS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005116.1

ENSEMBL proteins:

ENSP00000436318 ENSP00000433609 ENSP00000307870 ENSP00000436379

Reactome Protein details: O14618

CCS Human Recombinant Protein Products:

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	GenScript Purified and Recombinant Proteins for CCS
	Novus Biologicals CCS Proteins Novus Biologicals CCS Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for CCS
	Browse Proteins at Cloud-Clone Corp.

CCS Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for CCS OriGene Custom Antibody Services for CCS
	Novus Biologicals CCS Antibodies
	Abcam antibodies for CCS
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CCS
	LSBio Antibodies in human, mouse, rat for CCS

CCS Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CCS
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCS
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR006121 HeavyMe-assoc_HMA

IPR001424 SOD_Cu_Zn_dom

IPR024134 SOD_Cu/Zn_/chaperone

IPR018152 SOD_Cu/Zn_BS

Graphical View of Domain Structure for InterPro Entry O14618

ProtoNet protein and cluster: O14618

2 Blocks protein domains:

IPB001424 Copper/Zinc superoxide dismutase

IPB006121 Heavy metal transport/detoxification protein

UniProtKB/Swiss-Prot: CCS_HUMAN, O14618

Similarity: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family

Similarity: Contains 1 HMA domain

CCS for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CCS_HUMAN, O14618

Function: Delivers copper to copper zinc superoxide dismutase (SOD1)

Genatlas biochemistry entry for CCS:

copper chaperone for superoxide dismutase,S cerevisiae LYS7 ortholog

Gene Ontology (GO): Selected molecular function terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004784	superoxide dismutase activity	IBA	--
GO:0005375	copper ion transmembrane transporter activity	TAS	9726962
GO:0005507	copper ion binding	TAS	9726962
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IBA	--

CCS for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CCS:

Increased cilium length after

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ccs):

cellular

endocrine/exocrine gland

homeostasis/metabolism

reproductive system

CCS for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Ccs^tm1Pcw for CCS

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCS

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCS

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCS

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCS

miRNA Products:		miRTarBase miRNAs that target CCS: hsa-mir-484 (MIRT042263)

		Block miRNA regulation of human, mouse, rat CCS using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate CCS
		SwitchGear 3'UTR luciferase reporter plasmid: CCS 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CCS
		Predesigned siRNA for gene silencing in human, mouse, rat CCS

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCS

Clone Products:		OriGene clones in human, mouse for CCS (see all 6) OriGene ORF clones in mouse, rat for CCS OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CCS (NM_005333)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCS
		Browse ESI BIO Cell Lines and PureStem Progenitors for CCS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCS

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CCS_HUMAN, O14618: Cytoplasm

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	3
mitochondrion	3
extracellular	2
chloroplast	1
cytoskeleton	1
plasma membrane	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9726962
GO:0005737	cytoplasm	IDA	9726962
GO:0005743	mitochondrial inner membrane	IBA	--
GO:0005829	cytosol	TAS	--

CCS for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CCS About

See pathways by source

SuperPath

Contained pathways About

Amyotrophic lateral sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS)

0.63

Amyotrophic lateral sclerosis (ALS)

0.63

Cellular Senescence

Cellular responses to stress

0.81

Detoxification of Reactive Oxygen Species

Detoxification of Reactive Oxygen Species

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for CCS

Amyotrophic lateral sclerosis (ALS)

1 Reactome Pathway for CCS

Detoxification of Reactive Oxygen Species

1 Kegg Pathway (Kegg details for CCS):

Amyotrophic lateral sclerosis (ALS)

CCS for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including CCS:

Nephrotoxicity in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

Interactions:

GeneGlobe Interaction Network for CCS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CCS (O14618³ ENSP00000307870⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 103)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APBA1	Q02410³, ENSP00000265381⁴	I2D: score=3 STRING: ENSP00000265381
SOD1	P00441³, ENSP00000270142⁴	I2D: score=4 STRING: ENSP00000270142
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
XIAP	P98170³, ENSP00000347858⁴	I2D: score=1 STRING: ENSP00000347858
YWHAG	P61981³, ENSP00000306330⁴	I2D: score=1 STRING: ENSP00000306330

About this table

Gene Ontology (GO): Selected biological process terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006801	superoxide metabolic process	TAS	9295278
GO:0015680	intracellular copper ion transport	IBA	--
GO:0019430	removal of superoxide radicals	IBA	--
GO:0030001	metal ion transport	--	--
GO:0035434	copper ion transmembrane transport	TAS	9726962

CCS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CCS

2 HMDB Compounds for CCS About this table

Compound	Synonyms	CAS #	PubMed Ids
Copper	Cu (see all 2)	7440-50-8	--
Ondansetron	Ondansetron (see all 4)	99614-02-5	--

6 Novoseek inferred chemical compound relationships for CCS gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc superoxide	77.4	3	9726962 (1), 9886096 (1), 16531609 (1)
copper	77	103	12832419 (7), 16531609 (7), 12815046 (4), 11473116 (3) (see all 24)
superoxide	65.8	20	20154138 (2), 15064408 (2), 15993338 (1), 17504097 (1) (see all 13)
zinc	48.7	2	12832419 (1), 19227972 (1)
cysteine	36.6	4	12832419 (1), 16531609 (1), 18703498 (1)
oxygen	3.35	7	15064408 (3), 18703498 (2)

CCS for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CCS gene:

NM_005125.1

Unigene Cluster for CCS:

Copper chaperone for superoxide dismutase

Hs.502917 [show with all ESTs]

Unigene Representative Sequence: BM923192

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000533244(uc001oir.3) ENST00000530384 ENST00000526066 ENST00000530961

ENST00000526058 ENST00000531990 ENST00000310190 ENST00000534763 ENST00000525435

miRNA Products:		Block miRNA regulation of human, mouse, rat CCS using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate CCS
		SwitchGear 3'UTR luciferase reporter plasmid: CCS 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CCS
		Predesigned siRNA for gene silencing in human, mouse, rat CCS

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		GenScript: all cDNA clones in your preferred vector (see all 3): CCS (NM_005333)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCS

Primer Products:		OriGene qPCR primer pairs and template standards for CCS OriGene qSTAR qPCR primer pairs in human, mouse for CCS
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CCS
		QuantiTect SYBR Green Assays in human, mouse, rat CCS
		QuantiFast Probe-based Assays in human, mouse, rat CCS

Additional mRNA sequence:

AF002210.1 AY113179.1 BC105016.1 BC112055.1 CR541928.1

13 DOTS entries:

DT.451899 DT.95218453 DT.95297325 DT.403494 DT.95297322 DT.95297334 DT.100789265 DT.120718131

DT.120718145 DT.120718151 DT.97845684 DT.100789268 DT.97778415

Selected AceView cDNA sequences (see all 217):

CF131037 AA326686 BQ082513 BQ082527 CB105001 BQ082347 CR592698 BM543741

AA602749 NM_005125 BF437830 BX494932 BQ939809 BX089413 BQ708701 BQ447121

BG575138 CB105004 AI392849 BM725666 BQ651373 AA736394 BM675344 AA554225

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCS (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7	^	8a	·	8b
SP1:															-		-		-				-
SP2:															-		-		-
SP3:															-		-		-
SP4:
SP5:															-		-		-

ECgene alternative splicing isoforms for CCS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGGCCCCCA

About this image

CCS Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CCS Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.502917

UniProtKB/Swiss-Prot: CCS_HUMAN, O14618

Tissue specificity: Ubiquitous

Pathway & Disease-focused RT² Profiler PCR Arrays including CCS:

Nephrotoxicity in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CCS OriGene qSTAR qPCR primer pairs in human, mouse for CCS
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CCS
		QuantiTect SYBR Green Assays in human, mouse, rat CCS
		QuantiFast Probe-based Assays in human, mouse, rat CCS

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CCS gene from Selected species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccs^{1 , 5}	copper chaperone for superoxide dismutase^{1, 5}	86.01(n)¹ 86.86(a)¹		19 (4.11 cM)⁵ 12460¹ NM_016892.3¹ NP_058588.1¹ 4825366⁵
lizard (Anolis carolinensis)	Reptilia	CCS⁶	copper chaperone for superoxide dismutase	66(a)	1 ↔ 1	GL343961.1(33306-41170)
tropical clawed frog (Xenopus tropicalis)	Amphibia	ccs¹	copper chaperone for superoxide dismutase	60.76(n) 62.73(a)		496429 NM_001011020.1 NP_001011020.1
zebrafish (Danio rerio)	Actinopterygii	ccs¹	copper chaperone for superoxide dismutase	65.87(n) 71.71(a)		550489 NM_001204222.1 NP_001191151.1
fruit fly (Drosophila melanogaster)	Insecta	CCS^{1 , 3}	intracellular copper ion transport superoxide more³ CCS¹	48(a)³ 55.6(n)¹ 52.46(a)¹		46F1³ 46035¹ NM_001169637.2¹ NP_001163108.1¹
worm (Caenorhabditis elegans)	Secernentea	sod-1⁶ sod-5⁶	Protein SOD-5 (sod-5) mRNA, complete cds	43(a) 43(a)	1 ↔ many 1 ↔ many	II(6972712-6973892) WBGene00004930 II(4417683-4419131) WBGene00007036
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CCS1(YMR038C)⁴ CCS1¹	Copper chaperone for superoxide dismutase Sod1p, involved more⁴ CCS1¹	41.78(n)¹ 30.22(a)¹		13(348260-347511)⁴ 855054^{1, 4} NP_013752.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	CCS¹	CCS	47.27(n) 43.64(a)		837808 NM_101123.3 NP_563910.2
rice (Oryza sativa)	Liliopsida	Os04g0573200¹	Os04g0573200	48.34(n) 41.56(a)		4336726 NM_001060148.1 NP_001053613.1

ENSEMBL Gene Tree for CCS (if available)
TreeFam Gene Tree for CCS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CCS gene

SOD1² SOD3²

1 SIMAP similar gene for CCS using alignment to 5 protein entries: CCS_HUMAN (see all proteins):

SOD1

CCS for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147062018^1,2	C	untested¹	66278765(+)	`TTGATA/G/TATTTG`	1	--	us2k¹		1		NA	4550
rs148498944^1,2	C	--	66278660(+)	`TTCTCC/TCAGCT`	1	--	us2k¹		0	--	--	--	--
rs201257146^1,2	C	--	66278687(+)	`GATGGA/C/GAGGGA`	1	--	us2k¹		0	--	--	--	--
rs75894827^1,2	C	--	66278785(+)	`TTCTTG/TACGTA`	1	--	us2k¹		0	--	--	--	--
rs144214514^1,2	C	--	66278787(+)	`CTTGAC/TGTAGA`	1	--	us2k¹		0	--	--	--	--
rs146563586^1,2	C	--	66278981(+)	`GCCAGA/GTGGTT`	1	--	us2k¹		0	--	--	--	--
rs141303580^1,2	C	--	66278999(+)	`GCTCCA/GGCCCC`	1	--	us2k¹		0	--	--	--	--
rs144092876^1,2	C	--	66279017(+)	`TGGAAA/GGAGTC`	1	--	us2k¹		0	--	--	--	--
rs200576384^1,2	C	--	66279056(+)	`GCAGCC/TGCCTG`	1	--	us2k¹		1		EU	1321
rs143106957^1,2	C	--	66279070(+)	`CACGAA/C/TCTCAT`	1	--	us2k¹		1		NA	3644

HapMap Linkage Disequilibrium report for CCS (66360292 - 66373490 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for CCS: About this table

Variant ID	Type	Subtype	PubMed ID
nsv513321	CNV	Insertion	21212237
nsv363	CNV	Insertion	18451855
nsv522277	CNV	Loss	19592680
dgv1187n71	CNV	Loss	21882294
nsv897789	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): CCS

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603864 OMIM disorders: --

13 diseases for CCS:
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apical myocardial infarction hemopericardium choledochal cyst menkes disease

wilson disease lateral sclerosis amyotrophic lateral sclerosis alzheimer's disease

myocardial infarction cholangiocarcinoma bipolar disorder malaria

neuronitis

1 disease from the University of Copenhagen DISEASES database for CCS:

Menkes disease

CCS for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

2 Novoseek inferred disease relationships for CCS gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
amyotrophic lateral sclerosis	79.6	5	10793232 (2), 17504097 (1), 11585247 (1)
alzheimers disease	1.1	1	17504097 (1)

Genetic Association Database (GAD): CCS
Human Genome Epidemiology (HuGE) Navigator: CCS (7 documents)

Export disorders for CCS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCS gene, integrated from 10 sources (see all 54):
(articles sorted by number of sources associating them with CCS)

Utopia: connect your pdf to the dynamic
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The copper chaperone for superoxide dismutase. (PubMed id 9295278)^{1, 2, 3} Culotta V.C....Gitlin J.D. (J. Biol. Chem. 1997)
The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase. (PubMed id 9726962)^{1, 2, 9} Casareno R.L.B.... Gitlin J.D. (J. Biol. Chem. 1998)
Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination. (PubMed id 20154138)^{1, 2, 9} Brady G.F.... Duckett C.S. (Mol. Cell. Biol. 2010)
Cysteine-to-serine mutants of the human copper chaperone for superoxide dismutase reveal a copper cluster at a domain III dimer interface. (PubMed id 15736924)^{1, 2, 9} Stasser J.P.... Blackburn N.J. (Biochemistry 2005)
Molecular and biochemical characterization of a unique mutation in CCS, the human copper chaperone to superoxide dismutase. (PubMed id 22508683)^{1, 2} Huppke P.... Gartner J. (Hum. Mutat. 2012)
Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)^{1, 4} Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)^{1, 4} Harris S.E....Deary I.J. (BMC Genet. 2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Crystal structure of the second domain of the human copper chaperone for superoxide dismutase. (PubMed id 10677207)^{1, 2} Lamb A.L....Rosenzweig A.C. (Biochemistry 2000)
The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain. (PubMed id 9886096)^{1, 9} Rothstein J.D....Wong P.C. (J. Neurochem. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9973	HGNC: 1613	AceView: CCS	Ensembl:ENSG00000173992	euGenes: HUgn9973
ECgene: CCS	Kegg: 9973	H-InvDB: CCS

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCS	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CCS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCS gene:
Search GeneIP for patents involving CCS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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