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CCRN4L Gene

protein-coding   GIFtS: 52
GCID: GC04P139936

CCR4 Carbon Catabolite Repression 4-Like (S. Cerevisiae)

(Previous names: CCR4-like (carbon catabolite repression 4, S.cerevisiae))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCR4 Carbon Catabolite Repression 4-Like (S. Cerevisiae)1 2     CCR4L2 5
CCR4-Like (Carbon Catabolite Repression 4, S.Cerevisiae)1 2     CCR43 5
Carbon Catabolite Repression 4-Like Protein2 3     CCR4 Protein Homolog2
Circadian Deadenylase NOC2 3     nocturnin2
NOC2 3     EC 3.1.13.43

External Ids:    HGNC: 142541   Entrez Gene: 258192   Ensembl: ENSG000001510147   OMIM: 6084685   UniProtKB: Q9UK393   

Export aliases for CCRN4L gene to outside databases

Previous GC identifers: GC04P140842 GC04P140236 GC04P140403 GC04P140514 GC04P140294 GC04P140156 GC04P135667


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCRN4L Gene:
The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated
gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast
transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has
been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a
circadian clock effector. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCRN4L Gene:
CCRN4L (CCR4 carbon catabolite repression 4-like (S. cerevisiae)) is a protein-coding gene. Diseases associated with CCRN4L include retinitis, and lung cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ANGEL1.

UniProtKB/Swiss-Prot: NOCT_HUMAN, Q9UK39
Function: Component of the circadian clock or downstream effector of clock function. Exhibits a high amplitude
circadian rhythm with maximal levels in early evening. In constant darkness or constant light, the amplitude of
the rhythm decreases (By similarity)

summary for CCRN4L Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCRN4L gene promoter:
         Max1   AP-2gamma   NF-kappaB   Arnt   Roaz   AP-2beta   NF-kappaB1   AP-2alpha   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCRN4L promoter sequence
   Search Chromatin IP Primers for CCRN4L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCRN4L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.1   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q31.1

CCRN4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCRN4L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P139936:  view genomic region     (about GC identifiers)

Start:
139,936,943 bp from pter      End:
139,967,093 bp from pter
Size:
30,151 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NOCT_HUMAN, Q9UK39 (See protein sequence)
Recommended Name: Nocturnin  
Size: 431 amino acids; 48196 Da
Cofactor: Magnesium (By similarity)
Secondary accessions: D3DNY5 Q14D51 Q9HD93 Q9HD94 Q9HD95

Explore the universe of human proteins at neXtProt for CCRN4L: NX_Q9UK39

Explore proteomics data for CCRN4L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCRN4L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036250.2  
    ENSEMBL proteins: 
     ENSP00000280614  
    Reactome Protein details: Q9UK39

    CCRN4L Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CCRN4L

    CCRN4L Antibody Products:

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    CCRN4L Assay Products:

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    Cloud-Clone Corp. CLIAs for CCRN4L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q9UK39

    ProtoNet protein and cluster: Q9UK39

    UniProtKB/Swiss-Prot: NOCT_HUMAN, Q9UK39
    Similarity: Belongs to the CCR4/nocturin family


    CCRN4L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOCT_HUMAN, Q9UK39
    Function: Component of the circadian clock or downstream effector of clock function. Exhibits a high amplitude
    circadian rhythm with maximal levels in early evening. In constant darkness or constant light, the amplitude of
    the rhythm decreases (By similarity)
    Catalytic activity: Exonucleolytic cleavage of poly(A) to 5'-AMP

         Enzyme Number (IUBMB): EC 3.1.13.41

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10521507
    GO:0004535poly(A)-specific ribonuclease activity IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    CCRN4L for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccrn4l):
     growth/size/body  homeostasis/metabolism  liver/biliary system 

    CCRN4L for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccrn4ltm1Bjc for CCRN4L

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCRN4L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCRN4L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCRN4L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCRN4L

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCRN4L:
    hsa-let-7e-5p (MIRT051636), hsa-mir-296-3p (MIRT038417)

    Block miRNA regulation of human, mouse, rat CCRN4L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCRN4L (see all 20):
    hsa-miR-1287 hsa-miR-875-3p hsa-miR-301a hsa-miR-499-5p hsa-miR-208b hsa-miR-208a hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidCCRN4L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCRN4L
    Predesigned siRNA for gene silencing in human, mouse, rat CCRN4L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCRN4L

    Clone
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    OriGene clones in human, mouse for CCRN4L (see all 6)
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    GenScript: all cDNA clones in your preferred vector: CCRN4L (NM_012118)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCRN4L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCRN4L

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCRN4L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCRN4L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    mitochondrion2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005634nucleus TAS10521507
    GO:0005654nucleoplasm TAS--

    CCRN4L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCRN4L About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66
    2Cyclins and Cell Cycle Regulation
    Cell Cycle Control by BTG Proteins0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CCRN4L
        Cell Cycle Control by BTG Proteins

    1 Reactome Pathway for CCRN4L
        BMAL1:CLOCK,NPAS2 activates circadian gene expression



    CCRN4L for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CCRN4L: 
              Circadian Rhythms in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCRN4L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCRN4L (ENSP000002806144) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARNTLENSP000003743574STRING: ENSP00000374357
    CLOCKENSP000003087414STRING: ENSP00000308741
    NPAS2ENSP000003382834STRING: ENSP00000338283
    CNOT4ENSP000003546734STRING: ENSP00000354673
    DDX6ENSP000002640184STRING: ENSP00000264018
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IEA--
    GO:0006355regulation of transcription, DNA-templated TAS10521507
    GO:0006366transcription from RNA polymerase II promoter TAS10521507
    GO:0006397mRNA processing IEA--
    GO:0033962cytoplasmic mRNA processing body assembly IEA--

    CCRN4L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CCRN4L available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCRN4L gene: 
    NM_012118.3  

    Unigene Clusters for CCRN4L:

    CCR4 carbon catabolite repression 4-like (S. cerevisiae)
    Hs.639842 , Hs.656047  [show with all ESTs]
    Unigene Representative Sequences: AF199494, NM_012118
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280614(uc003ihk.1 uc003ihl.3) ENST00000515616
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCRN4L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCRN4L (see all 20):
    hsa-miR-1287 hsa-miR-875-3p hsa-miR-301a hsa-miR-499-5p hsa-miR-208b hsa-miR-208a hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidCCRN4L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCRN4L
    Predesigned siRNA for gene silencing in human, mouse, rat CCRN4L
    Clone
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    OriGene clones in human, mouse for CCRN4L (see all 6)
    OriGene ORF clones in mouse, rat for CCRN4L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCRN4L (NM_012118)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCRN4L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCRN4L
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCRN4L
    OriGene qSTAR qPCR primer pairs in human, mouse for CCRN4L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCRN4L
      QuantiTect SYBR Green Assays in human, mouse, rat CCRN4L
      QuantiFast Probe-based Assays in human, mouse, rat CCRN4L

    Additional mRNA sequence: 

    AF183961.1 AF199493.1 BC021963.2 BC023512.2 BC077723.1 BC113494.1 BC113500.1 

    4 DOTS entries:

    DT.92021033  DT.40294720  DT.121274165  DT.95202697 

    1 AceView cDNA sequence:

    BV188040 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCRN4L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTGGAAA
    CCRN4L Expression
    About this image

    CCRN4L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCRN4L Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.639842 Hs.656047
        Pathway & Disease-focused RT2 Profiler PCR Array including CCRN4L: 
              Circadian Rhythms in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCRN4L
    OriGene qSTAR qPCR primer pairs in human, mouse for CCRN4L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCRN4L
    QuantiTect SYBR Green Assays in human, mouse, rat CCRN4L
    QuantiFast Probe-based Assays in human, mouse, rat CCRN4L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCRN4L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CCRN4L gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccrn4l1 , 5 CCR4 carbon catabolite repression 4-like (S. cerevisiae)1, 5 85.3(n)1
    91.27(a)1
      3 (22.12 cM)5
    124571  NM_009834.21  NP_033964.11 
     512244475 
    chicken
    (Gallus gallus)
    Aves CCRN4L1 CCR4 carbon catabolite repression 4-like (S. cerevisiae) 76.09(n)
    81.36(a)
      404779  NM_001009928.1  NP_001009928.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCRN4L6
    CCR4 carbon catabolite repression 4-like (S. cerev...
    80(a)
    1 ↔ 1
    5(120425364-120430006)
    African clawed frog
    (Xenopus laevis)
    Amphibia ccrn4l-A2 CCR4 carbon catabolite repression 4-like, nocturnin 76.28(n)    U74761.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CCRN4L (2 of 2)6
    ccrn4la6
    CCR4 carbon catabolite repression 4-like (S. cerev...
    CCR4 carbon catabolite repression 4-like a (S. cer...
    65(a)
    56(a)
    1 ↔ many
    1 ↔ many
    1(12832675-12836850) ENSDARG00000078525
    14(48963052-48975762) ENSDARG00000077726
    fruit fly
    (Drosophila melanogaster)
    Insecta nocturin3
    cu1
    curled1 48(a)3
    53.87(n)1
    51.41(a)1
      86D93
    413391  NM_001104277.21  NP_001097747.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCR46
    Component of the CCR4-NOT transcriptional complex,...
    13(a)
    1 → many
    I(110846-113359) YAL021C


    ENSEMBL Gene Tree for CCRN4L (if available)
    TreeFam Gene Tree for CCRN4L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCRN4L gene
    ANGEL12  PDE122  ANGEL22  CNOT6L2  CNOT62  

    CCRN4L for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCRN4L
    PGOHUM00000242901


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCRN4L (see all 617)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472553931,2
    --139935098(+) TCCATG/TCACTT 1 -- us2k10--------
    rs1905048671,2
    --139935134(+) GCCTCC/TGCTCC 1 -- us2k10--------
    rs1818338871,2
    --139935193(+) CGTTGA/GGGGTG 1 -- us2k10--------
    rs1851877701,2
    --139935251(+) TGCCTC/TTTCTC 1 -- us2k10--------
    rs68273091,2
    C,H--139935291(+) ttcagC/Taaact 1 -- us2k16Minor allele frequency- T:0.02NS EA WA 540
    rs1897060931,2
    --139935336(+) CTATAC/TCCATA 1 -- us2k10--------
    rs1161208571,2
    F--139935339(+) TACCCA/GTATAT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1407934791,2
    --139935370(+) ATCAAC/TATTTT 1 -- us2k10--------
    rs1826772661,2
    --139935433(+) AAAAAA/TTCTTT 1 -- us2k10--------
    rs1863420221,2
    --139935476(+) CTCGAC/TAGACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCRN4L (139936943 - 139967093 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CCRN4L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728425CNV Deletion23290073
    esv1464767CNV Deletion17803354
    esv2040934CNV Deletion18987734
    esv2544225CNV Deletion19546169
    nsv880160CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608468    OMIM disorders: --

    3 diseases for CCRN4L:    
    About MalaCards
    retinitis    lung cancer    malaria


    CCRN4L for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCRN4L
    Human Genome Epidemiology (HuGE) Navigator: CCRN4L (4 documents)

    Export disorders for CCRN4L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCRN4L gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CCRN4L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion. (PubMed id 10521507)1, 2, 3, 9 Dupressoir A.... Heidmann T. (J. Biol. Chem. 1999)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter. (PubMed id 18587630)1, 9 Li R....Cao J.M. (Mol. Cell. Biochem. 2008)
    4. Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse. (PubMed id 11394964)1, 9 Wang Y....Besharse J.C. (BMC Dev. Biol. 2001)
    5. RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway. (PubMed id 22547059)1 Yi X....Shang Y. (J. Biol. Chem. 2012)
    6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    7. RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4. (PubMed id 16821125)1 Nakamura E.S....Saiki I. (amp 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Circadian regulation of nocturnin transcription by phosphorylated CREB in Xenopus retinal photoreceptor cells. (PubMed id 12370297)9 Liu X. and Green C.B. (Mol. Cell. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25819 HGNC: 14254 AceView: CCRN4L Ensembl:ENSG00000151014 euGenes: HUgn25819
    ECgene: CCRN4L H-InvDB: CCRN4L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCRN4L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCRN4L gene:
    Search GeneIP for patents involving CCRN4L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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