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Aliases for CCRN4L Gene

Aliases for CCRN4L Gene

  • CCR4 Carbon Catabolite Repression 4-Like (S. Cerevisiae) 2 3
  • CCR4-Like (Carbon Catabolite Repression 4, S.Cerevisiae) 2 3
  • Carbon Catabolite Repression 4-Like Protein 3 4
  • Circadian Deadenylase NOC 3 4
  • CCR4L 3 6
  • CCR4 4 6
  • NOC 3 4
  • CCR4 Protein Homolog 3
  • EC 3.1.13.4 4
  • Nocturnin 3
  • Ccr4c 3

External Ids for CCRN4L Gene

Previous GeneCards Identifiers for CCRN4L Gene

  • GC04P140842
  • GC04P140236
  • GC04P140403
  • GC04P140514
  • GC04P140294
  • GC04P140156
  • GC04P139936
  • GC04P135667

Summaries for CCRN4L Gene

Entrez Gene Summary for CCRN4L Gene

  • The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCRN4L Gene

CCRN4L (CCR4 Carbon Catabolite Repression 4-Like (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is PDE12.

UniProtKB/Swiss-Prot for CCRN4L Gene

  • Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCRN4L Gene

Genomics for CCRN4L Gene

Regulatory Elements for CCRN4L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCRN4L Gene

Start:
139,015,759 bp from pter
End:
139,045,939 bp from pter
Size:
30,181 bases
Orientation:
Plus strand

Genomic View for CCRN4L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCRN4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCRN4L Gene

Proteins for CCRN4L Gene

  • Protein details for CCRN4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK39-NOCT_HUMAN
    Recommended name:
    Nocturnin
    Protein Accession:
    Q9UK39
    Secondary Accessions:
    • D3DNY5
    • Q14D51
    • Q9HD93
    • Q9HD94
    • Q9HD95

    Protein attributes for CCRN4L Gene

    Size:
    431 amino acids
    Molecular mass:
    48196 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PPARG.

neXtProt entry for CCRN4L Gene

Proteomics data for CCRN4L Gene at MOPED

Post-translational modifications for CCRN4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCRN4L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCRN4L Gene

Domains for CCRN4L Gene

Protein Domains for CCRN4L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCRN4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK39

UniProtKB/Swiss-Prot:

NOCT_HUMAN :
  • Q9UK39
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with CCRN4L: view

No data available for Gene Families for CCRN4L Gene

Function for CCRN4L Gene

Molecular function for CCRN4L Gene

UniProtKB/Swiss-Prot CatalyticActivity: Exonucleolytic cleavage of poly(A) to 5-AMP
UniProtKB/Swiss-Prot Function: Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

Enzyme Numbers (IUBMB) for CCRN4L Gene

Gene Ontology (GO) - Molecular Function for CCRN4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10521507
GO:0003729 mRNA binding ISS --
GO:0004535 poly(A)-specific ribonuclease activity ISS --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CCRN4L: view
genes like me logo Genes that share phenotypes with CCRN4L: view

Animal Models for CCRN4L Gene

MGI Knock Outs for CCRN4L:

Animal Model Products

CRISPR Products

miRNA for CCRN4L Gene

miRTarBase miRNAs that target CCRN4L

No data available for Transcription Factor Targeting and HOMER Transcription for CCRN4L Gene

Localization for CCRN4L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCRN4L Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCRN4L Gene COMPARTMENTS Subcellular localization image for CCRN4L gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCRN4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IEA --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with CCRN4L: view

Pathways for CCRN4L Gene

genes like me logo Genes that share pathways with CCRN4L: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CCRN4L Gene

Gene Ontology (GO) - Biological Process for CCRN4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 10521507
GO:0006366 transcription from RNA polymerase II promoter TAS 10521507
GO:0006397 mRNA processing IEA --
GO:0007623 circadian rhythm TAS --
genes like me logo Genes that share ontologies with CCRN4L: view

Transcripts for CCRN4L Gene

mRNA/cDNA for CCRN4L Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCRN4L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCRN4L Gene

No ASD Table

Relevant External Links for CCRN4L Gene

GeneLoc Exon Structure for
CCRN4L
ECgene alternative splicing isoforms for
CCRN4L

Expression for CCRN4L Gene

mRNA expression in normal human tissues for CCRN4L Gene

mRNA differential expression in normal tissues according to GTEx for CCRN4L Gene

This gene is overexpressed in Liver (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCRN4L Gene

SOURCE GeneReport for Unigene cluster for CCRN4L Gene Hs.639842

mRNA Expression by UniProt/SwissProt for CCRN4L Gene

Q9UK39-NOCT_HUMAN
Tissue specificity: Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.
genes like me logo Genes that share expressions with CCRN4L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCRN4L Gene

Orthologs for CCRN4L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCRN4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCRN4L 35
  • 99.45 (n)
  • 99.73 (a)
CCRN4L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCRN4L 35
  • 85.76 (n)
  • 91.78 (a)
CCRN4L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCRN4L 35
  • 89.78 (n)
  • 96 (a)
CCRN4L 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccrn4l 35
  • 85.3 (n)
  • 91.27 (a)
Ccrn4l 16
Ccrn4l 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCRN4L 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCRN4L 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccrn4l 35
  • 85.87 (n)
  • 90.87 (a)
chicken
(Gallus gallus)
Aves CCRN4L 35
  • 76.09 (n)
  • 81.36 (a)
MNOC 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCRN4L 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ccrn4l-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccrn4l 35
  • 73.33 (n)
  • 78.9 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13994 35
zebrafish
(Danio rerio)
Actinopterygii CCRN4L (2 of 2) 36
  • 65 (a)
OneToMany
ccrn4la 36
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009893 35
  • 51.99 (n)
  • 46.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta cu 35
  • 53.87 (n)
  • 51.41 (a)
cu 36
  • 27 (a)
OneToOne
nocturin 37
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 36
  • 13 (a)
OneToMany
Species with no ortholog for CCRN4L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCRN4L Gene

ENSEMBL:
Gene Tree for CCRN4L (if available)
TreeFam:
Gene Tree for CCRN4L (if available)

Paralogs for CCRN4L Gene

Paralogs for CCRN4L Gene

Pseudogenes.org Pseudogenes for CCRN4L Gene

genes like me logo Genes that share paralogs with CCRN4L: view

Variants for CCRN4L Gene

Sequence variations from dbSNP and Humsavar for CCRN4L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs938836 -- 139,018,499(+) TTTAT(A/G)GTACT intron-variant
rs953951 -- 139,038,719(+) CTTTT(A/C)TCATC intron-variant
rs1112828 -- 139,035,816(+) ATTCA(G/T)ACTGT intron-variant
rs1356461 -- 139,016,063(+) CAGGG(A/C)TGCGC missense, reference
rs2271777 - 139,043,301(-) TGGGT(A/G)GGTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CCRN4L Gene

Variant ID Type Subtype PubMed ID
nsv880160 CNV Gain 21882294
esv2544225 CNV Deletion 19546169
esv2728425 CNV Deletion 23290073
esv2040934 CNV Deletion 18987734
esv1464767 CNV Deletion 17803354

Relevant External Links for CCRN4L Gene

HapMap Linkage Disequilibrium report
CCRN4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCRN4L Gene

Disorders for CCRN4L Gene

Relevant External Links for CCRN4L

Genetic Association Database (GAD)
CCRN4L
Human Genome Epidemiology (HuGE) Navigator
CCRN4L
genes like me logo Genes that share disorders with CCRN4L: view

No data available for UniProtKB/Swiss-Prot for CCRN4L Gene

Publications for CCRN4L Gene

  1. Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion. (PMID: 10521507) Dupressoir A. … Heidmann T. (J. Biol. Chem. 1999) 2 3 4 23
  2. Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse. (PMID: 11394964) Wang Y. … Besharse J.C. (BMC Dev. Biol. 2001) 3 23
  3. CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter. (PMID: 18587630) Li R. … Cao J.M. (Mol. Cell. Biochem. 2008) 3 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway. (PMID: 22547059) Yi X. … Shang Y. (J. Biol. Chem. 2012) 3

Products for CCRN4L Gene

Sources for CCRN4L Gene

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