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Aliases for CCRL2 Gene

Aliases for CCRL2 Gene

  • C-C Motif Chemokine Receptor Like 2 2 3
  • Chemokine (C-C Motif) Receptor-Like 2 2 3 5
  • Putative MCP-1 Chemokine Receptor 3 4
  • Atypical Chemokine Receptor 5 2 3
  • Chemokine Receptor CCR11 3 4
  • Chemokine Receptor X 3 4
  • CKRX 3 4
  • CRAM 3 4
  • HCR 3 4
  • CRAM-A 3
  • CRAM-B 3
  • CCR11 4
  • ACKR5 3
  • CCR6 4

External Ids for CCRL2 Gene

Previous GeneCards Identifiers for CCRL2 Gene

  • GC03P045689
  • GC03P046267
  • GC03P046409
  • GC03P9F0095

Summaries for CCRL2 Gene

Entrez Gene Summary for CCRL2 Gene

  • This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCRL2 Gene

CCRL2 (C-C Motif Chemokine Receptor Like 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor binding. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CCRL2 Gene

  • Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.

Gene Wiki entry for CCRL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCRL2 Gene

Genomics for CCRL2 Gene

Regulatory Elements for CCRL2 Gene

Promoters for CCRL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCRL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCRL2 Gene

Chromosome:
3
Start:
46,407,163 bp from pter
End:
46,412,997 bp from pter
Size:
5,835 bases
Orientation:
Plus strand

Genomic View for CCRL2 Gene

Genes around CCRL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCRL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCRL2 Gene

Proteins for CCRL2 Gene

  • Protein details for CCRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00421-CCRL2_HUMAN
    Recommended name:
    C-C chemokine receptor-like 2
    Protein Accession:
    O00421
    Secondary Accessions:
    • B4DKQ8
    • O75307
    • Q4VBB0
    • Q6IPX0
    • Q7KYQ9
    • Q96KP5
    • Q9UPG0

    Protein attributes for CCRL2 Gene

    Size:
    344 amino acids
    Molecular mass:
    39513 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report. These results are now controversial, and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed:15188357).

    Alternative splice isoforms for CCRL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCRL2 Gene

Proteomics data for CCRL2 Gene at MOPED

Post-translational modifications for CCRL2 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for CCRL2 Gene

Antibody Products

  • R&D Systems Antibodies for CCRL2 (CCRL2/CRAM-A/B)

No data available for DME Specific Peptides for CCRL2 Gene

Domains & Families for CCRL2 Gene

Gene Families for CCRL2 Gene

Protein Domains for CCRL2 Gene

Graphical View of Domain Structure for InterPro Entry

O00421

UniProtKB/Swiss-Prot:

CCRL2_HUMAN :
  • Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCRL2: view

Function for CCRL2 Gene

Molecular function for CCRL2 Gene

GENATLAS Biochemistry:
chemokine CC,beta receptor like 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
UniProtKB/Swiss-Prot Induction:
Up-regulated by CCL5 on the pre-B-cell lines NALM-6 and G2.

Gene Ontology (GO) - Molecular Function for CCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042379 chemokine receptor binding IPI 14530373
GO:0048020 CCR chemokine receptor binding IPI 20002784
genes like me logo Genes that share ontologies with CCRL2: view
genes like me logo Genes that share phenotypes with CCRL2: view

Animal Models for CCRL2 Gene

MGI Knock Outs for CCRL2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCRL2 Gene

Localization for CCRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCRL2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCRL2 Gene COMPARTMENTS Subcellular localization image for CCRL2 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for CCRL2 Gene

Pathways & Interactions for CCRL2 Gene

genes like me logo Genes that share pathways with CCRL2: view

Interacting Proteins for CCRL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349967%0d%0a9606.ENSP00000308815%0d%0a
Selected Interacting proteins: O00421-CCRL2_HUMAN ENSP00000349967 for CCRL2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070098 chemokine-mediated signaling pathway TAS 9473515
genes like me logo Genes that share ontologies with CCRL2: view

No data available for SIGNOR curated interactions for CCRL2 Gene

Drugs & Compounds for CCRL2 Gene

(2) Drugs for CCRL2 Gene - From: IUPHAR and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL19 Pharma Agonist 0
chemerin C-terminal peptide Pharma Agonist 0
genes like me logo Genes that share compounds with CCRL2: view

Transcripts for CCRL2 Gene

Unigene Clusters for CCRL2 Gene

Chemokine (C-C motif) receptor-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCRL2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -
SP3:

Relevant External Links for CCRL2 Gene

GeneLoc Exon Structure for
CCRL2
ECgene alternative splicing isoforms for
CCRL2

Expression for CCRL2 Gene

mRNA expression in normal human tissues for CCRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCRL2 Gene

This gene is overexpressed in Whole Blood (x8.8), Lung (x4.9), Spleen (x4.1), and Adipose - Visceral (Omentum) (x4.0).

SOURCE GeneReport for Unigene cluster for CCRL2 Gene Hs.535713

mRNA Expression by UniProt/SwissProt for CCRL2 Gene

O00421-CCRL2_HUMAN
Tissue specificity: Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
genes like me logo Genes that share expression patterns with CCRL2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCRL2 Gene

Orthologs for CCRL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCRL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCRL2 35
  • 98.69 (n)
  • 98.03 (a)
CCRL2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCRL2 36
  • 64 (a)
OneToOne
LOC515976 35
  • 76.76 (n)
  • 66.17 (a)
dog
(Canis familiaris)
Mammalia LOC484788 35
  • 76.48 (n)
  • 62.39 (a)
CCRL2 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccrl2 36
  • 49 (a)
OneToOne
Ccrl2 16
Ccrl2 35
  • 67.25 (n)
  • 52.49 (a)
oppossum
(Monodelphis domestica)
Mammalia CCRL2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCRL2 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccrl2 35
  • 67.34 (n)
  • 52.31 (a)
Species with no ortholog for CCRL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCRL2 Gene

ENSEMBL:
Gene Tree for CCRL2 (if available)
TreeFam:
Gene Tree for CCRL2 (if available)

Paralogs for CCRL2 Gene

(15) SIMAP similar genes for CCRL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCRL2: view

Variants for CCRL2 Gene

Sequence variations from dbSNP and Humsavar for CCRL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_026488 -
VAR_026489 -
VAR_026490 -
VAR_049385 -
rs1140865 -- 46,409,393(+) ATCAC(A/T)TAACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCRL2 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294

Variation tolerance for CCRL2 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.04; 80.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCRL2 Gene

HapMap Linkage Disequilibrium report
CCRL2
Human Gene Mutation Database (HGMD)
CCRL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCRL2 Gene

Disorders for CCRL2 Gene

Relevant External Links for CCRL2

Genetic Association Database (GAD)
CCRL2
Human Genome Epidemiology (HuGE) Navigator
CCRL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCRL2

No disorders were found for CCRL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCRL2 Gene

Publications for CCRL2 Gene

  1. Cloning and characterization of a novel human chemokine receptor. (PMID: 9473515) Fan P. … Li Y. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 67
  2. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. (PMID: 20002784) Leick M. … Burger M. (Immunology 2010) 3 23
  3. Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis. (PMID: 15188357) Galligan C.L. … Yoshimura T. (Arthritis Rheum. 2004) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. (PMID: 25340798) Kauwe J.S. … Goate A.M. (PLoS Genet. 2014) 3

Products for CCRL2 Gene

Sources for CCRL2 Gene

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