Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCRL2 Gene

Aliases for CCRL2 Gene

  • Chemokine (C-C Motif) Receptor-Like 2 2 3
  • Putative MCP-1 Chemokine Receptor 3 4
  • Atypical Chemokine Receptor 5 2 3
  • Chemokine Receptor CCR11 3 4
  • Chemokine Receptor X 3 4
  • CRAM 3 4
  • CKRX 3 4
  • HCR 3 4
  • C-C Chemokine Receptor-Like 2 3
  • CRAM-A 3
  • CRAM-B 3
  • CCR11 4
  • ACKR5 3
  • CCR6 4

External Ids for CCRL2 Gene

Summaries for CCRL2 Gene

Entrez Gene Summary for CCRL2 Gene

  • This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCRL2 Gene

CCRL2 (Chemokine (C-C Motif) Receptor-Like 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine receptor activity and CCR chemokine receptor binding. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCRL2 Gene

  • Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses

Gene Wiki entry for CCRL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCRL2 Gene

Genomics for CCRL2 Gene

Genomic Location for CCRL2 Gene

Start:
46,407,163 bp from pter
End:
46,412,997 bp from pter
Size:
5,835 bases
Orientation:
Plus strand

Genomic View for CCRL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCRL2 Gene

Regulatory Elements for CCRL2 Gene

Proteins for CCRL2 Gene

  • Protein details for CCRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00421-CCRL2_HUMAN
    Recommended name:
    C-C chemokine receptor-like 2
    Protein Accession:
    O00421
    Secondary Accessions:
    • B4DKQ8
    • O75307
    • Q4VBB0
    • Q6IPX0
    • Q7KYQ9
    • Q96KP5
    • Q9UPG0

    Protein attributes for CCRL2 Gene

    Size:
    344 amino acids
    Molecular mass:
    39513 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report. These results are now controversial, and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed:15188357).

    Alternative splice isoforms for CCRL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCRL2 Gene

Proteomics data for CCRL2 Gene at MOPED

Post-translational modifications for CCRL2 Gene

Other Protein References for CCRL2 Gene

No data available for DME Specific Peptides for CCRL2 Gene

Domains for CCRL2 Gene

Gene Families for CCRL2 Gene

HGNC:
  • ACKR :GPCR / Class A : Chemokine receptors : Atypical
IUPHAR :

Protein Domains for CCRL2 Gene

UniProtKB/Swiss-Prot:

CCRL2_HUMAN
Domain:
  • Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors:
    • O00421
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • O00421
genes like me logo Genes that share domains with CCRL2: view

Function for CCRL2 Gene

Molecular function for CCRL2 Gene

GENATLAS Biochemistry: chemokine CC,beta receptor like 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses
UniProtKB/Swiss-Prot Induction: Up-regulated by CCL5 on the pre-B-cell lines NALM-6 and G2.

Gene Ontology (GO) - Molecular Function for CCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity IEA --
GO:0042379 chemokine receptor binding IPI 14530373
GO:0048020 CCR chemokine receptor binding IPI 20002784
genes like me logo Genes that share ontologies with CCRL2: view
genes like me logo Genes that share phenotypes with CCRL2: view

Animal Models for CCRL2 Gene

MGI Knock Outs for CCRL2:

miRNA for CCRL2 Gene

miRTarBase miRNAs that target CCRL2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCRL2 Gene

Localization for CCRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCRL2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCRL2 Gene COMPARTMENTS Subcellular localization image for CCRL2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 20002784
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CCRL2: view

Pathways for CCRL2 Gene

genes like me logo Genes that share pathways with CCRL2: view

Interacting Proteins for CCRL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349967%0d%0a9606.ENSP00000308815%0d%0a
Selected Interacting proteins: ENSP00000349967 O00421-CCRL2_HUMAN for CCRL2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CCRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response ISS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0070098 chemokine-mediated signaling pathway TAS 9473515
genes like me logo Genes that share ontologies with CCRL2: view

Compounds for CCRL2 Gene

(2) IUPHAR Ligand for CCRL2 Gene

Ligand Type Action Affinity Pubmed IDs
CCL19 Agonist Agonist 9.1
chemerin C-terminal peptide Agonist Agonist
genes like me logo Genes that share compounds with CCRL2: view

Transcripts for CCRL2 Gene

Unigene Clusters for CCRL2 Gene

Chemokine (C-C motif) receptor-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCRL2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -
SP3:

Relevant External Links for CCRL2 Gene

GeneLoc Exon Structure for
CCRL2
ECgene alternative splicing isoforms for
CCRL2

Expression for CCRL2 Gene

mRNA expression in normal human tissues for CCRL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCRL2 Gene

This gene is overexpressed in Whole Blood (8.8), Lung (4.9), Spleen (4.1), and Adipose - Visceral (Omentum) (4.0).

SOURCE GeneReport for Unigene cluster for CCRL2 Gene Hs.535713

mRNA Expression by UniProt/SwissProt for CCRL2 Gene

O00421-CCRL2_HUMAN
Tissue specificity: Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
genes like me logo Genes that share expressions with CCRL2: view

Orthologs for CCRL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCRL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCRL2 36
  • 98.69 (n)
  • 98.03 (a)
CCRL2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCRL2 37
  • 64 (a)
OneToOne
LOC515976 36
  • 76.76 (n)
  • 66.17 (a)
dog
(Canis familiaris)
Mammalia CCRL2 37
  • 61 (a)
OneToOne
LOC484788 36
  • 76.48 (n)
  • 62.39 (a)
mouse
(Mus musculus)
Mammalia Ccrl2 36
  • 67.25 (n)
  • 52.49 (a)
Ccrl2 16
Ccrl2 37
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCRL2 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCRL2 37
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccrl2 36
  • 67.34 (n)
  • 52.31 (a)
Species with no ortholog for CCRL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCRL2 Gene

ENSEMBL:
Gene Tree for CCRL2 (if available)
TreeFam:
Gene Tree for CCRL2 (if available)

Paralogs for CCRL2 Gene

Selected SIMAP similar genes for CCRL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCRL2: view

Variants for CCRL2 Gene

Sequence variations from dbSNP and Humsavar for CCRL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1140865 -- 46,409,393(+) ATCAC(A/T)TAACT utr-variant-3-prime
rs2157061 -- 46,410,011(+) TGTGA(A/G)CTACC downstream-variant-500B
rs4560336 -- 46,409,867(+) TGAAT(G/T)CTTTG downstream-variant-500B
rs11574444 -- 46,409,216(+) TACAG(C/G)AAGAA utr-variant-3-prime
rs34557465 -- 46,409,921(+) ACTAC(-/A)AAAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CCRL2 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294

Relevant External Links for CCRL2 Gene

HapMap Linkage Disequilibrium report
CCRL2
Human Gene Mutation Database (HGMD)
CCRL2

Disorders for CCRL2 Gene

Relevant External Links for CCRL2

Genetic Association Database (GAD)
CCRL2
Human Genome Epidemiology (HuGE) Navigator
CCRL2
genes like me logo Genes that share disorders with CCRL2: view

No data available for UniProtKB/Swiss-Prot for CCRL2 Gene

Publications for CCRL2 Gene

  1. Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis. (PMID: 15188357) Galligan C.L. … Yoshimura T. (Arthritis Rheum. 2004) 3 4 23
  2. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. (PMID: 20002784) Leick M. … Burger M. (Immunology 2010) 3 4 23
  3. Cloning and characterization of a novel human chemokine receptor. (PMID: 9473515) Fan P. … Li Y. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  4. Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner. (PMID: 18397265) Hartmann T.N. … Burger M. (Immunology 2008) 4 23
  5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 49

Products for CCRL2 Gene

Sources for CCRL2 Gene

Back to Top

Content