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CCRL2 Gene

protein-coding   GIFtS: 62
GCID: GC03P046448

Chemokine (C-C Motif) Receptor-Like 2

  Search for CCRL2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chemokine (C-C Motif) Receptor-Like 21 2     HCR2 3
Atypical Chemokine Receptor 51 2     ACKR52
Chemokine Receptor CCR112 3     CRAM-A2
Chemokine Receptor X2 3     CRAM-B2
Putative MCP-1 Chemokine Receptor2 3     C-C Chemokine Receptor-Like 22
CKRX2 3     CCR113
CRAM2 3     CCR63

External Ids:    HGNC: 16121   Entrez Gene: 90342   Ensembl: ENSG000001217977   OMIM: 6083795   UniProtKB: O004213   
ORGUL members:         

Export aliases for CCRL2 gene to outside databases

Previous GC identifers: GC03P045689 GC03P046267 GC03P046409 GC03P9F0095


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCRL2 Gene:
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and
most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the
recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in
primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during
monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region
where the chemokine receptor gene cluster is located. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCRL2 Gene:
CCRL2 (chemokine (C-C motif) receptor-like 2) is a protein-coding gene. GO annotations related to this gene include CCR chemokine receptor binding and chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCRL2_HUMAN, O00421
Function: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role
in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2
ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses

Gene Wiki entry for CCRL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCRL2 gene promoter:
         USF1   STAT1   USF-1   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCRL2 promoter sequence
   Search Chromatin IP Primers for CCRL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCRL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CCRL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCRL2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P046448:  view genomic region     (about GC identifiers)

Start:
46,448,654 bp from pter      End:
46,454,488 bp from pter
Size:
5,835 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCRL2_HUMAN, O00421 (See protein sequence)
Recommended Name: C-C chemokine receptor-like 2  
Size: 344 amino acids; 39513 Da
Miscellaneous: It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via
intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor
interaction was provided in this report. These results are now controversial, and other studies failed to confirm
CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using
CCRL2-transfected cells (PubMed:15188357)
Secondary accessions: B4DKQ8 O75307 Q4VBB0 Q6IPX0 Q7KYQ9 Q96KP5 Q9UPG0
Alternative splicing: 2 isoforms:  O00421-1   O00421-2   

Explore the universe of human proteins at neXtProt for CCRL2: NX_O00421

Explore proteomics data for CCRL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3

  • See CCRL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124382.1  NP_003956.2  

    ENSEMBL proteins: 
     ENSP00000381994   ENSP00000349967   ENSP00000383677   ENSP00000414957   ENSP00000383678  
    Reactome Protein details: O00421

    CCRL2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CCRL2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ACKR: GPCR / Class A : Chemokine receptors : Atypical

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCRL2
    Chemokine receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O00421

    ProtoNet protein and cluster: O00421

    1 Blocks protein domain: IPB000355 Chemokine receptor signature

    UniProtKB/Swiss-Prot: CCRL2_HUMAN, O00421
    Domain: Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of
    functional chemokine receptors
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CCRL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCRL2_HUMAN, O00421
    Function: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role
    in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2
    ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses
    Induction: Up-regulated by CCL5 on the pre-B-cell lines NALM-6 and G2

         Genatlas biochemistry entry for CCRL2:
    chemokine CC,beta receptor like 3,G protein coupled receptor superfamily

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity IEA--
    GO:0042379chemokine receptor binding IPI14530373
    GO:0048020CCR chemokine receptor binding IPI--
         
    Find genes that share ontologies with CCRL2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccrl2):
     cellular  hematopoietic system  immune system  normal 

    Find genes that share phenotypes with CCRL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CCRL2: Ccrl2tm1Ssoz Ccrl2tm1Lex Ccrl2tm1Dgen

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCRL2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCRL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCRL2

    miRNA
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    miRTarBase miRNAs that target CCRL2:
    hsa-mir-26b-5p (MIRT029835)

    Block miRNA regulation of human, mouse, rat CCRL2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCRL2:
    hsa-miR-3919
    SwitchGear 3'UTR luciferase reporter plasmidCCRL2 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCRL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCRL2_HUMAN, O00421: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with CCRL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCRL2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with CCRL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCRL2
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCRL2 (see all 7)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling

    1 BioSystems Pathway for CCRL2
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for CCRL2
        Chemokine receptors bind chemokines


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCRL2: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCRL2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CCRL2 (O004213 ENSP000003499674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL19Q997313I2D: score=1 
    FAM107BENSP000001817964STRING: ENSP00000181796
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response ISS--
    GO:0007186G-protein coupled receptor signaling pathway TAS9473515
    GO:0070098chemokine-mediated signaling pathway TAS9473515

    Find genes that share ontologies with CCRL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCRL2

    2 IUPHAR Ligands for CCRL2 (CCRL2)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCL19
    AgonistUnknown7.3620002784
    chemerin C-terminal peptide
    AgonistAgonist7.3618165312



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCRL2 gene (2 alternative transcripts): 
    NM_001130910.1  NM_003965.4  

    Unigene Cluster for CCRL2:

    Chemokine (C-C motif) receptor-like 2
    Hs.535713  [show with all ESTs]
    Unigene Representative Sequence: AF015525
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399036(uc003cpp.4) ENST00000495870 ENST00000357392(uc010hjg.3 uc010hjf.3)
    ENST00000400880 ENST00000433848 ENST00000400882(uc021wxc.1) ENST00000441909

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CCRL2:
    hsa-miR-3919
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    Additional mRNA sequence: 

    AF014958.1 AF015524.1 AF015525.1 AJ344142.1 AK296673.1 AK313312.1 AY337001.1 BC025717.1 
    BC071682.1 BC096075.1 BC096076.3 BC099623.3 

    2 DOTS entries:

    DT.105784  DT.100746890 

    Selected AceView cDNA sequences (see all 25):

    NM_003965 AI954582 AY337001 CD370587 AF014958 BC025717 AF015525 AI343408 
    AF015524 BI819787 BV174724 AW300833 CF147784 AJ344142 BG386374 BI834559 
    BQ892457 BE871331 CD520843 BE465578 AI288845 BX480211 AW293465 AW236610 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCRL2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
    SP1:        -     -     -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for CCRL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCRL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAAATGT
    CCRL2 Expression
    About this image


    CCRL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    CCRL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCRL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535713

    UniProtKB/Swiss-Prot: CCRL2_HUMAN, O00421
    Tissue specificity: Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone
    marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including
    monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor
    cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid
    arthritis patients

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCRL2: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCRL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCRL2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccrl21 , 5 chemokine (C-C motif) receptor-like 21, 5 67.25(n)1
    52.49(a)1
      9 (60.92 cM)5
    541991  NM_017466.41  NP_059494.21 
     1110548355 


    ENSEMBL Gene Tree for CCRL2 (if available)
    TreeFam Gene Tree for CCRL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCRL2 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCR72  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    15 SIMAP similar genes for CCRL2 using alignment to 3 protein entries:     CCRL2_HUMAN (see all proteins):
    CCR3    GHSR    CCR5    CCR2    CCR-5    ACKR2
    CCBP2    CCR1    CX3CR1    CCR8    CCR4    CCR7
    CXCR6    XCR1    AGTR1

    Find genes that share paralogs with CCRL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCRL2 (see all 151)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115744281,2
    C,F,H--46446721(+) GAAGGT/ACATGC 1 -- us2k113Minor allele frequency- A:0.08NA NS EA CSA 1766
    rs1451383981,2
    --46446746(+) CAGGGC/TGATCC 1 -- us2k10--------
    rs115744291,2
    C,F--46446810(+) GTTTTT/CACTTG 1 -- us2k12Minor allele frequency- C:0.24NA CSA 42
    rs1406612491,2
    --46446838(+) CATGAC/TTCTGT 1 -- us2k10--------
    rs1820117181,2
    --46446906(+) GTGTGC/TGTACT 1 -- us2k10--------
    rs1458256281,2
    C--46447015(+) TTCAAC/GATCCT 1 -- us2k10--------
    rs1480026431,2
    --46447090(+) CTGTAA/GGGGGT 2 -- us2k10--------
    rs1416630221,2
    --46447123(+) ATGACA/CCCCAC 2 -- us2k10--------
    rs1501197491,2
    --46447254(+) GCACAA/CGTGGA 2 -- us2k10--------
    rs1860348671,2
    --46447326(+) ATAGTC/TCTCTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCRL2 (46448654 - 46454488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCRL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876734CNV Gain21882294

    Human Gene Mutation Database (HGMD): CCRL2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCRL2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCRL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608379    OMIM disorders: --


    Find genes that share disorders with CCRL2           About GenesLikeMe

    Genetic Association Database (GAD): CCRL2
    Human Genome Epidemiology (HuGE) Navigator: CCRL2 (4 documents)

    Export disorders for CCRL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCRL2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with CCRL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human chemokine receptor. (PubMed id 9473515)1, 2, 3 Fan P.... Li Y. (Biochem. Biophys. Res. Commun. 1998)
    2. Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis. (PubMed id 15188357)1, 2, 9 Galligan C.L.... Yoshimura T. (Arthritis Rheum. 2004)
    3. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. (PubMed id 20002784)1, 2, 9 Leick M....Burger M. (Immunology 2010)
    4. Genome-wide association study implicates PARD3B-based AIDS restriction. (PubMed id 21502085)1, 4 Troyer J.L....O'Brien S.J. (J. Infect. Dis. 2011)
    5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    6. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    7. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner. (PubMed id 18397265)2, 9 Hartmann T.N.... Burger M. (Immunology 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9034 HGNC: 1612 AceView: CCRL2 Ensembl:ENSG00000121797 euGenes: HUgn9034
    ECgene: CCRL2 H-InvDB: CCRL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCRL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCRL2 gene:
    Search GeneIP for patents involving CCRL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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