Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCR9 Gene

protein-coding   GIFtS: 62
GCID: GC03P045903

chemokine (C-C motif) receptor 9


(Previous symbol: GPR28)
 Explore 29 diseases affiliated with
CCR9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCR9    

Aliases
for CCR9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Chemokine (C-C Motif) Receptor 91 2     G Protein-Coupled Receptor 282
GPR-9-61 2 3     CCR-93
GPR281 2 3     C-C CKR-93
CDw1991 2     CDw199 Antigen3
CC-CKR-92 3     G-Protein Coupled Receptor 283
C-C Chemokine Receptor Type 92     

External Ids:    HGNC: 16101   Entrez Gene: 108032   Ensembl: ENSG000001735857   OMIM: 6047385   UniProtKB: P516863   
ORGUL members:    fRNAdb10:FR156814      
H-InvDB:HIT000071306    
NCBI:AF145207    
NONCODE:n332996 n410094    
RNAdb:HIV1432    

Export aliases for CCR9 gene to outside databases

Previous GC identifers: GC03P045168 GC03P045747 GC03P045888


Summaries
for CCR9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCR9:
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven
transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the
thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is
CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon,
suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune
responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene
cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
Function: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium
ions level. Alternative coreceptor with CD4 for HIV-1 infection

Gene Wiki entry for CCR9

fRNAdb sequence ontology for CCR9:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for CCR9

Genomic Views
for CCR9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCR9 gene promoter:
         c-Rel   RFX1   oct-B3   oct-B2   Nkx2-2   HTF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCR9 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCR9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

CCR9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P045903:  view genomic region     (about GC identifiers)

Start:
 45,927,996 bp from pter      End:
 45,944,667 bp from pter
Size:
 16,672 bases      Orientation:
 plus strand
ORGUL member locations:
Legend (see complete legend)

  • n410094
  • FR0156814
  • n332996
45927995 45936331 45944667 chr3

Proteins
for CCR9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686 (See protein sequence)
Recommended Name: C-C chemokine receptor type 9  
Size: 369 amino acids; 42016 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2
Sequence caution: Sequence=AAH95516.1; Type=Erroneous initiation;
Secondary accessions: Q4VBM3 Q549E0 Q9UQQ6
Alternative splicing: 2 isoforms:  P51686-1   P51686-2   

Explore the universe of human proteins at neXtProt for CCR9: NX_P51686

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51686

    • CCR9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243298.1  NP_006632.2  NP_112477.1  

    ENSEMBL proteins: 
     ENSP00000350256   ENSP00000379292   ENSP00000393267   ENSP00000348260  
    Reactome Protein details: P51686
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CCR9 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CCR9
    OriGene Custom Protein Services for CCR9 
    GenScript Custom Purified and Recombinant Proteins Services for CCR9
    Novus Biologicals CCR9 Protein
    Novus Biologicals CCR9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CCR9

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10229797


    CCR9 for ontologies           About GeneDecksing



    CCR9 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCR9
    R&D Systems Antibodies for CCR9
    OriGene Antibodies: CCR9
    OriGene Custom Antibody Services for CCR9 
    GenScript Custom Superior Antibodies Services for CCR9
    Novus Biologicals CCR9 Antibodies
    Abcam antibodies for CCR9 
    Uscn Antibodies for CCR9
    Search ThermoFisher Antibodies for CCR9

    Assay Products for CCR9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCR9
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCR9

    Protein Domains /
    Families
    for CCR9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCR9 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004069 Chemokine_CCR9
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P51686

    ProtoNet protein and cluster: P51686

    2 Blocks protein families:
    IPB000355 Chemokine receptor signature
    IPB004069 C-C chemokine receptor type 9 signature


    UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for CCR9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
    Function: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium
    ions level. Alternative coreceptor with CD4 for HIV-1 infection

         Genatlas biochemistry entry for CCR9:
    chemokine CC,beta receptor 9,G protein coupled receptor superfamily,highly expressed in thymus,receptor for the
    chemokine TECK

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCR9
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR9:
    hsa-miR-589* hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmid: CCR9 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCR9 (see all 7)
    OriGene shRNA RFP: CCR9
    OriGene siRNA: CCR9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR9

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCR9

    Clone
    Products:             		EMD Millipore Clones for the Expression of CCR9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR9 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR9 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CCR9 (NM_031200)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR9 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CCR9
    Search LifeMap BioReagents cell lines for CCR9

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR9

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004950chemokine receptor activity TAS10229797
    GO:0005515protein binding ----
    GO:0016493C-C chemokine receptor activity IEA--


    CCR9 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CCR9: Ccr9tm1Lov Ccr9tm1.1Mal
         5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ccr9):
     behavior/neurological  cellular  digestive/alimentary  hematopoietic system  immune system 

    CCR9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCR9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    		Peptide ligand-binding receptors0.61
    2Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    3Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    4Chemokine Signaling
    		Chemokine Signaling1.00
    		Chemokine signaling pathway0.33
    5PEDF Induced Signaling
    		STAT3 Pathway0.47
    		Cytokine-cytokine receptor interaction0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CCR9
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR9 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    1 BioSystems Pathway for CCR9 
        GPCRs, Class A Rhodopsin-like

    5/8        Reactome Pathways for CCR9 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CCR9):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Intestinal immune network for IgA production


    CCR9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCR9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for CCR9 (P516863 ENSP000003502564) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL25O154443, ENSP000003750864I2D: score=2 STRING: ENSP00000375086
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB1ENSP000003771414STRING: ENSP00000377141
    ARRB2ENSP000002692604STRING: ENSP00000269260
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006955immune response TAS10229797
    GO:0006968cellular defense response TAS10544196
    GO:0007186G-protein coupled receptor signaling pathway TAS10544196
    GO:0007204elevation of cytosolic calcium ion concentration TAS10229797


    CCR9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCR9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCR9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCR9

    1 HMDB Compound for CCR9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    4 Novoseek chemical compound relationships for CCR9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 95.6 17 10544196 (4), 20081876 (2), 15086554 (2), 15492285 (1) (see all 10)
    tarc 57.4 1 15996192 (1)
    glycogen 2.06 1 11997671 (1)
    calcium 0 1 12220670 (1)

    Search CenterWatch for drugs/clinical trials and news about CCR9 

    Transcripts
    for CCR9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    		 1 fRNAdb Secondary structure:


    REFSEQ mRNAs for CCR9 gene (3 alternative transcripts): 
    NM_001256369.1  NM_006641.3  NM_031200.2  

    Unigene Cluster for CCR9:

    Chemokine (C-C motif) receptor 9
    Hs.225946  [show with all ESTs]
    Unigene Representative Sequence: NM_001256369
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357632(uc010hiv.2 uc003coz.2 uc003cpa.2) ENST00000395963
    ENST00000463197 ENST00000422395 ENST00000355983

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCR9
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR9:
    hsa-miR-589* hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmid: CCR9 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCR9 (see all 7)
    OriGene shRNA RFP: CCR9
    OriGene siRNA: CCR9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR9
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR9 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR9 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CCR9 (NM_031200)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR9 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR9

    Additional cDNA sequence: 

    AF145207.1 AF145439.1 AF145440.1 AJ132337.1 AK312824.1 AK313366.1 BC069678.1 BC095516.1 

    2 DOTS entries:

    DT.70101854  DT.92416571 

    10 AceView cDNA sequences:

    NM_006641 NM_031200 AI926898 CF147770 AF145440 AF145439 BC069678 AJ132337 
    AF145207 AI762921 

    GeneLoc Exon Structure


    Expression
    for CCR9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCR9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTGGCAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCR9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BloodPeripheral BloodImmature B CellsBlood
    BloodPeripheral BloodPre-B CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CCR9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCR9

    SOURCE GeneReport for Unigene cluster: Hs.225946

    UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
    Tissue specificity: Highly expressed in the thymus and low in lymph nodes and spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCR9: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR9
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR9

    Orthologs
    for CCR9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCR9 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCR91 chemokine (C-C motif) receptor 9 61.86(n)
    52.13(a)    		   428454  NM_001045840.1  NP_001039305.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CCR96
    		 --
    		 48(a)
    		 1 ↔ 1
    		 GL343324.1(273777-275633)
    zebrafish
    (Danio rerio)    		 Actinopterygii ccr9a1 chemokine (C-C motif) receptor 9a 56.62(n)
    46.76(a)    		   553366  XM_001343852.1  XP_001343888.1 


    ENSEMBL Gene Tree for CCR9 (if available)
    TreeFam Gene Tree for CCR9 (if available) 

    Paralogs
    for CCR9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCR9 gene
    CCR62  CCR52  CXCR62  CXCR32  XCR12  CCBP22  CCRL22  CCR72  
    CX3CR12  CCR82  CXCR22  CCRL12  CCR42  CXCR12  CCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/41 SIMAP similar genes for CCR9 using alignment to 3 protein entries:     CCR9_HUMAN (see all proteins) (see all similar genes):
    CCR7    CCR-5    CCR2    CXCR6    CCR5    AGTR1
    CCBP2    BLR1    CCR6    CXCR2    CXCR5    IL8RB
    CCR4    CCR8    CCRL1    CXCR1    CXCR4    CCR3

    CCR9 for paralogs           About GeneDecksing



    Genomic Variants
    for CCR9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/495 NCBI SNPs in CCR9 are shown (see all 495)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs745865491,2
    		C,--45926043(+) CACACC/TGGTGC 3 -- us2k14Minor allele frequency- T:0.31NA CSA WA 242
    rs1900121941,2
    		--45926145(+) CTTGTA/GTGCTC 3 -- us2k10--------
    rs1158266131,2
    		F,--45926390(+) CCAGAG/CCATCT 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1808453281,2
    		--45926439(+) ATTTGC/TAATGA 3 -- us2k10--------
    rs2012785231,2
    		--45926493(+) GTTCC-/TTTAAG 3 -- us2k10--------
    rs113868421,2
    		C,F,--45926495(+) TCCTTC/-AAGGC 3 -- us2k13Minor allele frequency- -:0.33NA CSA 6
    rs76135481,2
    		C,F,A,H,--45926569(+) TGTTGG/ACCTTT 3 -- us2k1 tfbs326Minor allele frequency- A:0.40NS EA WA NA CSA 2769
    rs1472167001,2
    		--45926601(+) AAGTGC/TACCTT 3 -- us2k10--------
    rs1175425321,2
    		F,--45926613(+) TGCATC/ACCTTT 3 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1155219431,2
    		F,--45926615(+) CATCCC/TTTTGC 3 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for CCR9 (45927996 - 45944667 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CCR9
         1 CNV: 98301

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR9
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR9

    Disorders / Diseases
    for CCR9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCR9 for disorders           About GeneDecksing

    OMIM gene information: 604738 117360 600644 252350 601869 606658 607135 608448 608982 609299    
    20/29 diseases for CCR9 (see all 29):    About MalaCards
    graft versus host disease    food allergy    systemic lupus erythematosus    lymphocytic leukemia
    lupus erythematosus    celiac disease    inflammatory bowel disease    rheumatoid arthritis
    chronic lymphocytic leukemia    acute lymphocytic leukemia    lymphoblastic leukemia    allergic asthma
    sjogren's syndrome    crohn's disease    leukemia    tonsillitis
    arthritis    asthma    endometriosis    ovarian cancer

    6 Novoseek disease relationships for CCR9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 56.3 5 14559839 (3), 19567201 (1)
    celiac disease 34.8 3 17570212 (2)
    lymphoblastic leukemia acute 22.7 1 19567201 (1)
    metastasis 7.38 10 18245522 (3), 15086554 (3), 19567201 (2), 19756884 (1) (see all 5)
    rheumatoid arthritis 0 1 16207316 (1)
    tumors 0 5 19756884 (2), 18245522 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCR9 (13 documents)

    Export disorders for CCR9 gene to outside databases

    Publications
    for CCR9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCR9 gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with CCR9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. (PubMed id 10229797)1, 2, 3, 9 Zaballos A.... Marquez G. (1999)
    2. CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta- 15 that differ in their sensitivities to ligand. (PubMed id 10640743)1, 2, 9 Yu C.-R.... Farber J.M. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. CC chemokine receptor 9 enhances proliferation in pan creatic intraepithelial neoplasia and pancreatic cancer cells. (PubMed id 19756884)1, 9 Shen X....Kim J. (2009)
    5. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. (PubMed id 10544196)1, 9 Zabel B.A....Andrew D.P. (1999)
    6. Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation. (PubMed id 17570212)1, 9 Olaussen R.W....Farstad I.N. (2007)
    7. Activation of CCR9/CCL25 in cutaneous melanoma mediates preferential metastasis to the small intestine. (PubMed id 18245522)1, 9 Amersi F.F....Hoon D.S. (2008)
    8. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. (PubMed id 15623660)1, 9 Singh S....Lillard J.W. (2004)
    9. Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. (PubMed id 19525985)1, 9 Inamoto Y....Naoe T. (2010)
    10. Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia. (PubMed id 14559839)1, 9 Qiuping Z....Jinquan T. (2003)

    External Searches for CCR9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCR9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10803 HGNC: 1610 AceView: CCR9 Ensembl:ENSG00000173585 euGenes: HUgn10803
    ECgene: CCR9 Kegg: 10803 H-InvDB: CCR9

    Other Databases showing CCR9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCR9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCR9 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    Intellectual Property
    for CCR9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCR9 gene:
    Search GeneIP for patents involving CCR9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CCR9 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Clones for the Expression of CCR9
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CCR9
     EMD Millipore Purified and/or Recombinant CCR9 Protein
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CCR9 (CCR9)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for CCR9   OriGene shRNA RFP for CCR9  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCR9   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR9  
     OriGene Protein Over-expression Lysate for CCR9   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CCR9   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR9   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR9  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCR9   OriGene Custom Protein Services for CCR9  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCR9
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR9
     GenScript Custom Purified and Recombinant Proteins Services for CCR9 GenScript cDNA clones with any tag delivered in your preferred vector for CCR9
     GenScript Custom Assay Services for CCR9 GenScript Custom Superior Antibodies Services for CCR9
     GenScript Custom overexpressing Cell Line Services for CCR9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CCR9 promoter
     Search Chromatin IP Primers for CCR9
     RT2 qPCR Primer Assay in human, mouse, rat CCR9
     Search GNC Networks for CCR9
     SABiosciences PCR Arrays including human, mouse, rat CCR9
     Search Tocris compounds for CCR9
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCR9 antibodies
     CCR9 proteins
     CCR9 lysates
     Antibodies for CCR9
     See all of Abcam's Antibodies, Kits and Proteins for CCR9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CCR9 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CCR9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR9
     SwitchGear 3'UTR luciferase reporter plasmids for CCR9
     SwitchGear Promoter luciferase reporter plasmids for CCR9
     Search ThermoFisher Antibodies for CCR9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR9
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CCR9 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4