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CCR9 Gene

protein-coding   GIFtS: 65
GCID: GC03P045903

Chemokine (C-C Motif) Receptor 9


(Previous symbol: GPR28)
  See CCR9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 4

Aliases
Chemokine (C-C Motif) Receptor 91 2     G Protein-Coupled Receptor 282
GPR281 2 3     CCR-93
CC-CKR-92 3     C-C CKR-93
GPR-9-62 3     CDw199 Antigen3
CDw1992     G-Protein Coupled Receptor 283
C-C Chemokine Receptor Type 92     

External Ids:    HGNC: 16101   Entrez Gene: 108032   Ensembl: ENSG000001735857   OMIM: 6047385   UniProtKB: P516863   
ORGUL members:    fRNAdb10:FR156814      
H-InvDB12:HIT000071306    
NCBI13:AF145207    
NONCODE14:n332996 n410094    
RNAdb15:HIV1432    

Export aliases for CCR9 gene to outside databases

Previous GC identifers: GC03P045168 GC03P045747 GC03P045888


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCR9 Gene:
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven
transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators
of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this
receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small
intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional
specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the
chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan
2012)

GeneCards Summary for CCR9 Gene:
CCR9 (chemokine (C-C motif) receptor 9) is a protein-coding gene. Diseases associated with CCR9 include celiac disease. GO annotations related to this gene include C-C chemokine receptor activity and chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
Function: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular
calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection

Gene Wiki entry for CCR9 Gene

fRNAdb sequence ontology for CCR9:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for CCR9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCR9 gene promoter:
         c-Rel   RFX1   oct-B3   oct-B2   Nkx2-2   HTF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR9 promoter sequence
   Search Chromatin IP Primers for CCR9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

CCR9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P045903:  view genomic region     (about GC identifiers)

Start:
45,927,996 bp from pter      End:
45,944,667 bp from pter
Size:
16,672 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CCR9

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686 (See protein sequence)
Recommended Name: C-C chemokine receptor type 9  
Size: 369 amino acids; 42016 Da
Miscellaneous: EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2
Sequence caution: Sequence=AAH95516.1; Type=Erroneous initiation;
Secondary accessions: Q4VBM3 Q549E0 Q9UQQ6
Alternative splicing: 2 isoforms:  P51686-1   P51686-2   

Explore the universe of human proteins at neXtProt for CCR9: NX_P51686

Explore proteomics data for CCR9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn32

  • See CCR9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243298.1  NP_006632.2  NP_112477.1  

    ENSEMBL proteins: 
     ENSP00000350256   ENSP00000379292   ENSP00000393267   ENSP00000348260  
    Reactome Protein details: P51686

    CCR9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CCR9

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR9
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004069 Chemokine_CCR9
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P51686

    ProtoNet protein and cluster: P51686

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB004069 C-C chemokine receptor type 9 signature


    UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CCR9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR9_HUMAN, P51686
    Function: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular
    calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection

         Genatlas biochemistry entry for CCR9:
    chemokine CC,beta receptor 9,G protein coupled receptor superfamily,highly expressed in thymus,receptor for the
    chemokine TECK

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS10229797
    GO:0005515protein binding ----
    GO:0016493C-C chemokine receptor activity IEA--
         
    Find genes that share ontologies with CCR9           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ccr9):
     behavior/neurological  digestive/alimentary  hematopoietic system  immune system 

    Find genes that share phenotypes with CCR9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CCR9: Ccr9tm1Lov Ccr9tm1.1Mal

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR9

    miRNA
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    miRTarBase miRNAs that target CCR9:
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    Block miRNA regulation of human, mouse, rat CCR9 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CCR9:
    hsa-miR-589* hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmidCCR9 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCR9_HUMAN, P51686: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10229797
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with CCR9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCR9 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    4Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with CCR9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCR9
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR9 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    1 BioSystems Pathway for CCR9
        GPCRs, Class A Rhodopsin-like


    2 Reactome Pathways for CCR9
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for CCR9):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Intestinal immune network for IgA production

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR9: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CCR9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCR9 (P516863 ENSP000003502564) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL25O154443, ENSP000003750864I2D: score=2 STRING: ENSP00000375086
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB1ENSP000003771414STRING: ENSP00000377141
    ARRB2ENSP000002692604STRING: ENSP00000269260
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006955immune response IEA--
    GO:0006968cellular defense response TAS10544196
    GO:0007186G-protein coupled receptor signaling pathway TAS10544196
    GO:0007204positive regulation of cytosolic calcium ion concentration TAS10229797

    Find genes that share ontologies with CCR9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCR9

    1 HMDB Compound for CCR9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 IUPHAR Ligands for CCR9 (CCR9)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCL25
    AgonistFull agonist--
    [125I]CCL25
    AgonistFull agonist--

    4 Novoseek inferred chemical compound relationships for CCR9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 95.6 17 10544196 (4), 20081876 (2), 15086554 (2), 15492285 (1) (see all 10)
    tarc 57.4 1 15996192 (1)
    glycogen 2.06 1 11997671 (1)
    calcium 0 1 12220670 (1)



    Find genes that share compounds with CCR9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for CCR9 gene (3 alternative transcripts): 
    NM_001256369.1  NM_006641.3  NM_031200.2  

    Unigene Cluster for CCR9:

    Chemokine (C-C motif) receptor 9
    Hs.225946  [show with all ESTs]
    Unigene Representative Sequence: NM_001256369
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357632(uc010hiv.2 uc003coz.2 uc003cpa.2) ENST00000395963
    ENST00000463197 ENST00000422395 ENST00000355983
    miRNA
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    hsa-miR-589* hsa-miR-216b
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    Additional mRNA sequence: 

    AF145207.1 AF145439.1 AF145440.1 AJ132337.1 AK312824.1 AK313366.1 BC069678.1 BC095516.1 

    2 DOTS entries:

    DT.70101854  DT.92416571 

    10 AceView cDNA sequences:

    AI926898 NM_006641 AF145207 CF147770 AJ132337 NM_031200 AF145439 BC069678 
    AF145440 AI762921 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCR9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGGCAAA
    CCR9 Expression
    About this image


    CCR9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 9 entries
             Large Pre B-Cells Hematopoietic Bone Marrow
             cd4+ cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             Double Positive Thymocytes Thymus
             Thymus   
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    CCR9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCR9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.225946

    UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
    Tissue specificity: Highly expressed in the thymus and low in lymph nodes and spleen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR9: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCR9 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr91 , 5 chemokine (C-C motif) receptor 91, 5 84.73(n)1
    85.64(a)1
      9 (74.33 cM)5
    127691  NM_009913.61  NP_034043.11 
     1236784395 
    chicken
    (Gallus gallus)
    Aves CCR91 chemokine (C-C motif) receptor 9 60.85(n)
    50.47(a)
      428454  NM_001045840.1  NP_001039305.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCR96
    chemokine (C-C motif) receptor 9
    49(a)
    1 ↔ 1
    GL343324.1(273777-275633)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004892811 c-C chemokine receptor type 9-like 55.78(n)
    51.7(a)
      100489281  XM_002940798.2  XP_002940844.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003342531 c-C chemokine receptor type 9-like 53.75(n)
    46.87(a)
      100334253  XM_002666630.3  XP_002666676.3 


    ENSEMBL Gene Tree for CCR9 (if available)
    TreeFam Gene Tree for CCR9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCR9 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCRL22  CCR72  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CCR9 using alignment to 3 protein entries:     CCR9_HUMAN (see all proteins) (see all similar genes):
    CCR7    CCR2    CCR-5    CXCR6    CCR5    ACKR2
    AGTR1    BLR1    CCBP2    CCR6    CXCR2    CXCR5
    IL8RB    ACKR4    CCR4    CCR8    CCRL1    CXCR1

    Find genes that share paralogs with CCR9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCR9 (see all 545)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745865491,2
    C,F--45856940(+) CACACC/TGGTGC 3 -- us2k14Minor allele frequency- T:0.31NA CSA WA 242
    rs770391491,2
    F--45856960(+) TTCTCC/TTCTTC 3 -- us2k11Minor allele frequency- T:0.01WA 118
    rs46827981,2
    --45856997(+) CTCCCC/GCGAGA 3 -- us2k1 trp30--------
    rs1900121941,2
    --45857042(+) CTTGTA/GTGCTC 3 -- us2k10--------
    rs1158266131,2
    F--45857287(+) CCAGAG/CCATCT 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1808453281,2
    --45857336(+) ATTTGC/TAATGA 3 -- us2k10--------
    rs2012785231,2
    --45857390(+) GTTCC-/TTTAAG 3 -- us2k10--------
    rs76135481,2
    C,F,A,H--45857466(+) TGTTGG/ACCTTT 3 -- us2k1 tfbs326Minor allele frequency- A:0.40NS EA WA NA CSA 2769
    rs1472167001,2
    C--45857498(+) AAGTGC/TACCTT 3 -- us2k10--------
    rs1175425321,2
    C,F--45857510(+) TGCATC/ACCTTT 3 -- us2k11Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for CCR9 (45927996 - 45944667 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCR9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2462115CNV Insertion19546169
    nsv834678CNV Gain17160897
    nsv876734CNV Gain21882294
    nsv876736CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604738OMIM information: 117360 600644 252350 601869 606658 607135 608448 608982 609299    
    1 disease for CCR9:    
    About MalaCards
    celiac disease


    Find genes that share disorders with CCR9           About GenesLikeMe

    6 Novoseek inferred disease relationships for CCR9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 56.3 5 14559839 (3), 19567201 (1)
    celiac disease 34.8 3 17570212 (2)
    lymphoblastic leukemia acute 22.7 1 19567201 (1)
    metastasis 7.38 10 18245522 (3), 15086554 (3), 19567201 (2), 19756884 (1) (see all 5)
    rheumatoid arthritis 0 1 16207316 (1)
    tumors 0 5 19756884 (2), 18245522 (1)

    Genetic Association Database (GAD): CCR9
    Human Genome Epidemiology (HuGE) Navigator: CCR9 (13 documents)

    Export disorders for CCR9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCR9 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with CCR9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. (PubMed id 10229797)1, 2, 3, 9 Zaballos A.... Marquez G. (J. Immunol. 1999)
    2. Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. (PubMed id 19525985)1, 4, 9 Inamoto Y....Naoe T. (Bone Marrow Transplant. 2010)
    3. CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta- 15 that differ in their sensitivities to ligand. (PubMed id 10640743)1, 2, 9 Yu C.-R.... Farber J.M. (J. Immunol. 2000)
    4. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. CC chemokine receptor 9 enhances proliferation in pancreatic intraepithelial neoplasia and pancreatic cancer cells. (PubMed id 19756884)1, 9 Shen X....Kim J. (J. Gastrointest. Surg. 2009)
    10. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. (PubMed id 10544196)1, 9 Zabel B.A....Andrew D.P. (J. Exp. Med. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10803 HGNC: 1610 AceView: CCR9 Ensembl:ENSG00000173585 euGenes: HUgn10803
    ECgene: CCR9 Kegg: 10803 H-InvDB: CCR9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCR9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCR9 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCR9 gene:
    Search GeneIP for patents involving CCR9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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