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Aliases for CCR9 Gene

Aliases for CCR9 Gene

  • Chemokine (C-C Motif) Receptor 9 2 3
  • CC-CKR-9 3 4
  • GPR-9-6 3 4
  • GPR28 3 4
  • C-C Chemokine Receptor Type 9 3
  • G Protein-Coupled Receptor 28 3
  • G-Protein Coupled Receptor 28 4
  • CDw199 Antigen 4
  • C-C CKR-9 4
  • CDw199 3
  • CCR-9 4

External Ids for CCR9 Gene

Previous HGNC Symbols for CCR9 Gene

  • GPR28

Previous GeneCards Identifiers for CCR9 Gene

  • GC03P045168
  • GC03P045747
  • GC03P045888

Summaries for CCR9 Gene

Entrez Gene Summary for CCR9 Gene

  • The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CCR9 Gene

CCR9 (Chemokine (C-C Motif) Receptor 9) is a Protein Coding gene. Diseases associated with CCR9 include ileitis and celiac disease. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR9 Gene

  • Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection

Gene Wiki entry for CCR9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR9 Gene

Genomics for CCR9 Gene

Regulatory Elements for CCR9 Gene

Genomic Location for CCR9 Gene

Start:
45,886,504 bp from pter
End:
45,903,177 bp from pter
Size:
16,674 bases
Orientation:
Plus strand

Genomic View for CCR9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR9 Gene

Proteins for CCR9 Gene

  • Protein details for CCR9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51686-CCR9_HUMAN
    Recommended name:
    C-C chemokine receptor type 9
    Protein Accession:
    P51686
    Secondary Accessions:
    • Q4VBM3
    • Q549E0
    • Q9UQQ6

    Protein attributes for CCR9 Gene

    Size:
    369 amino acids
    Molecular mass:
    42016 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2
    SequenceCaution:
    • Sequence=AAH95516.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCR9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR9 Gene

Proteomics data for CCR9 Gene at MOPED

Post-translational modifications for CCR9 Gene

  • Glycosylation at Asn32
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCR9 Gene

Domains for CCR9 Gene

Gene Families for CCR9 Gene

HGNC:
  • CD :CD molecules
  • CCR :GPCR / Class A : Chemokine receptors : C-C motif
IUPHAR :

Suggested Antigen Peptide Sequences for CCR9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51686

UniProtKB/Swiss-Prot:

CCR9_HUMAN :
  • P51686
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR9: view

Function for CCR9 Gene

Molecular function for CCR9 Gene

GENATLAS Biochemistry: chemokine CC,beta receptor 9,G protein coupled receptor superfamily,highly expressed in thymus,receptor for the chemokine TECK
UniProtKB/Swiss-Prot Function: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection

Gene Ontology (GO) - Molecular Function for CCR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 10229797
GO:0005515 protein binding --
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR9: view
genes like me logo Genes that share phenotypes with CCR9: view

Animal Models for CCR9 Gene

MGI Knock Outs for CCR9:

Animal Model Products

CRISPR Products

miRNA for CCR9 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCR9 Gene

Localization for CCR9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR9 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR9 Gene COMPARTMENTS Subcellular localization image for CCR9 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CCR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10229797
GO:0009986 cell surface IDA 18308860
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CCR9: view

Pathways for CCR9 Gene

genes like me logo Genes that share pathways with CCR9: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CCR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006955 immune response IEA --
GO:0006968 cellular defense response TAS 10544196
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 10229797
genes like me logo Genes that share ontologies with CCR9: view

Compounds for CCR9 Gene

(1) HMDB Compounds for CCR9 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) IUPHAR Ligand for CCR9 Gene

Ligand Type Action Affinity Pubmed IDs
CCL25 Agonist Agonist 7.6
[125I]CCL25 Agonist Full agonist

(4) Novoseek inferred chemical compound relationships for CCR9 Gene

Compound -log(P) Hits PubMed IDs
teck 95.6 15
tarc 57.4 1
glycogen 2.06 1
calcium 0 1
genes like me logo Genes that share compounds with CCR9: view

Transcripts for CCR9 Gene

mRNA/cDNA for CCR9 Gene

Unigene Clusters for CCR9 Gene

Chemokine (C-C motif) receptor 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR9 Gene

No ASD Table

Relevant External Links for CCR9 Gene

GeneLoc Exon Structure for
CCR9
ECgene alternative splicing isoforms for
CCR9

Expression for CCR9 Gene

mRNA expression in normal human tissues for CCR9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR9 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (26.8), Spleen (5.1), and Whole Blood (4.3).

SOURCE GeneReport for Unigene cluster for CCR9 Gene Hs.225946

mRNA Expression by UniProt/SwissProt for CCR9 Gene

P51686-CCR9_HUMAN
Tissue specificity: Highly expressed in the thymus and low in lymph nodes and spleen.
genes like me logo Genes that share expressions with CCR9: view

In Situ Assay Products

No data available for Protein expression for CCR9 Gene

Orthologs for CCR9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR9 35
  • 99.37 (n)
  • 100 (a)
CCR9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCR9 35
  • 86.07 (n)
  • 89.34 (a)
CCR9 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR9 35
  • 86.61 (n)
  • 85.52 (a)
CCR9 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr9 35
  • 84.73 (n)
  • 85.64 (a)
Ccr9 16
Ccr9 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCR9 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr9 35
  • 85.64 (n)
  • 86.45 (a)
chicken
(Gallus gallus)
Aves CCR9 35
  • 60.85 (n)
  • 50.47 (a)
CCR9 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCR9 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489281 35
  • 55.78 (n)
  • 51.7 (a)
zebrafish
(Danio rerio)
Actinopterygii ccr9a 36
  • 44 (a)
OneToMany
ccr9b 36
  • 39 (a)
OneToMany
ccr9b 36
  • 39 (a)
OneToMany
LOC100334253 35
  • 53.75 (n)
  • 46.87 (a)
Species with no ortholog for CCR9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR9 Gene

ENSEMBL:
Gene Tree for CCR9 (if available)
TreeFam:
Gene Tree for CCR9 (if available)

Paralogs for CCR9 Gene

genes like me logo Genes that share paralogs with CCR9: view

Variants for CCR9 Gene

Sequence variations from dbSNP and Humsavar for CCR9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_020068 -
VAR_029208 -

Structural Variations from Database of Genomic Variants (DGV) for CCR9 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294
nsv834678 CNV Gain 17160897
nsv876736 CNV Gain 21882294
esv2462115 CNV Insertion 19546169

Relevant External Links for CCR9 Gene

HapMap Linkage Disequilibrium report
CCR9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR9 Gene

Disorders for CCR9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CCR9 Gene including...

Search for CCR9 Gene in MalaCards »

(6) Novoseek inferred disease relationships for CCR9 Gene

Disease -log(P) Hits PubMed IDs
t-all 56.3 4
celiac disease 34.8 2
lymphoblastic leukemia acute 22.7 1
metastasis 7.38 10
rheumatoid arthritis 0 1

Relevant External Links for CCR9

Genetic Association Database (GAD)
CCR9
Human Genome Epidemiology (HuGE) Navigator
CCR9
genes like me logo Genes that share disorders with CCR9: view

No data available for UniProtKB/Swiss-Prot for CCR9 Gene

Publications for CCR9 Gene

  1. Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. (PMID: 10229797) Zaballos A. … Marquez G. (J. Immunol. 1999) 2 3 4 23
  2. Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. (PMID: 19525985) Inamoto Y. … Naoe T. (Bone Marrow Transplant. 2010) 3 23 48
  3. CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta- 15 that differ in their sensitivities to ligand. (PMID: 10640743) Yu C.-R. … Farber J.M. (J. Immunol. 2000) 3 4 23
  4. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. (PMID: 10544196) Zabel B.A. … Andrew D.P. (J. Exp. Med. 1999) 3 23
  5. TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. (PMID: 10498628) Youn B.S. … Broxmeyer H.E. (Blood 1999) 3 23

Products for CCR9 Gene

Sources for CCR9 Gene

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