Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCR9 Gene

protein-coding   GIFtS: 65
GCID: GC03P045903

Chemokine (C-C Motif) Receptor 9


(Previous symbol: GPR28)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
Chemokine (C-C Motif) Receptor 91 2     G Protein-Coupled Receptor 282
GPR281 2 3     CCR-93
CC-CKR-92 3     C-C CKR-93
GPR-9-62 3     CDw199 Antigen3
CDw1992     G-Protein Coupled Receptor 283
C-C Chemokine Receptor Type 92     

External Ids:    HGNC: 16101   Entrez Gene: 108032   Ensembl: ENSG000001735857   OMIM: 6047385   UniProtKB: P516863   
ORGUL members:    fRNAdb10:FR156814      
H-InvDB12:HIT000071306    
NCBI13:AF145207    
NONCODE14:n332996 n410094      
RNAdb15:HIV1432    

Export aliases for CCR9 gene to outside databases

Previous GC identifers: GC03P045168 GC03P045747 GC03P045888


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCR9 Gene:
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven
transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators
of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this
receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small
intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional
specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the
chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan
2012)

GeneCards Summary for CCR9 Gene: 
CCR9 (chemokine (C-C motif) receptor 9) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CCR9 include food allergy, and celiac disease, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and STAT3 Pathway. GO annotations related to this gene include C-C chemokine receptor activity and chemokine receptor activity. An important paralog of this gene is CCR6.

UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
Function: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular
calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection

Gene Wiki entry for CCR9 Gene

fRNAdb sequence ontology for CCR9:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for CCR9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCR9 gene promoter:
         c-Rel   RFX1   oct-B3   oct-B2   Nkx2-2   HTF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR9 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCR9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

CCR9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P045903:  view genomic region     (about GC identifiers)

Start:
45,927,996 bp from pter      End:
45,944,667 bp from pter
Size:
16,672 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CCR9

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686 (See protein sequence)
Recommended Name: C-C chemokine receptor type 9  
Size: 369 amino acids; 42016 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2
Sequence caution: Sequence=AAH95516.1; Type=Erroneous initiation;
Secondary accessions: Q4VBM3 Q549E0 Q9UQQ6
Alternative splicing: 2 isoforms:  P51686-1   P51686-2   

Explore the universe of human proteins at neXtProt for CCR9: NX_P51686

Explore proteomics data for CCR9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51686

  • CCR9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCR9 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243298.1  NP_006632.2  NP_112477.1  

    ENSEMBL proteins: 
     ENSP00000350256   ENSP00000379292   ENSP00000393267   ENSP00000348260  
    Reactome Protein details: P51686
    Human Recombinant Protein Products for CCR9: 
    EMD Millipore Purified and/or Recombinant CCR9 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCR9
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCR9
    GenScript Custom Purified and Recombinant Proteins Services for CCR9
    Novus Biologicals CCR9 Protein
    Novus Biologicals CCR9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCR9 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10229797
    GO:0016021integral to membrane ----

    CCR9 for ontologies           About GeneDecksing



    CCR9 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCR9
    R&D Systems Antibodies for CCR9
    OriGene Antibodies for CCR9
    OriGene Custom Antibody Services for CCR9
    GenScript Custom Superior Antibodies Services for CCR9
    Novus Biologicals CCR9 Antibodies
    Abcam antibodies for CCR9
    Cloud-Clone Corp. Antibodies for CCR9 
    ThermoFisher Antibodies for CCR9
    LSBio Antibodies in human, mouse, rat for CCR9 

    Assay Products for CCR9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCR9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCR9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCR9 
    Cloud-Clone Corp. CLIAs for CCR9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR9 
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004069 Chemokine_CCR9
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P51686

    ProtoNet protein and cluster: P51686

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB004069 C-C chemokine receptor type 9 signature


    UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CCR9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR9_HUMAN, P51686
    Function: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular
    calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection

         Genatlas biochemistry entry for CCR9:
    chemokine CC,beta receptor 9,G protein coupled receptor superfamily,highly expressed in thymus,receptor for the
    chemokine TECK

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS10229797
    GO:0005515protein binding ----
    GO:0016493C-C chemokine receptor activity IEA--
    GO:0019957C-C chemokine binding ----
         
    CCR9 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ccr9):
     behavior/neurological  cellular  digestive/alimentary  hematopoietic system  immune system 

    CCR9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CCR9: Ccr9tm1Lov Ccr9tm1.1Mal

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCR9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCR9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR9 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCR9
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR9:
    hsa-miR-589* hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmidCCR9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCR9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCR9
    Sirion Biotech Customized adenovirus for overexpression of CCR9

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of CCR9
    OriGene clones in human, mouse for CCR9 (see all 12)
    OriGene ORF clones in mouse, rat for CCR9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCR9 (NM_031200)
    Sino Biological Human cDNA Clone for CCR9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR9
    Sirion Biotech Customized lentivirus for stable overexpression of CCR9 
                         Customized lentivirus expression plasmids for stable overexpression of CCR9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCR9
    Search LifeMap BioReagents cell lines for CCR9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCR9 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCR9
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR9 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    1 BioSystems Pathway for CCR9
        GPCRs, Class A Rhodopsin-like


    5/8        Reactome Pathways for CCR9 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CCR9):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Intestinal immune network for IgA production


    CCR9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCR9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for CCR9 (P516863 ENSP000003502564) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL25O154443, ENSP000003750864I2D: score=2 STRING: ENSP00000375086
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB1ENSP000003771414STRING: ENSP00000377141
    ARRB2ENSP000002692604STRING: ENSP00000269260
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006955immune response IEA--
    GO:0006968cellular defense response TAS10544196
    GO:0007186G-protein coupled receptor signaling pathway TAS10544196
    GO:0007204elevation of cytosolic calcium ion concentration TAS10229797

    CCR9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCR9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCR9

    1 HMDB Compound for CCR9    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 IUPHAR Ligands for CCR9 (CCR9)    About this table 
    LigandTypeActionAffinityPubmed IDs
    CCL25
    AgonistFull agonist--
    [125I]CCL25
    AgonistFull agonist--

    4 Novoseek inferred chemical compound relationships for CCR9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teck 95.6 17 10544196 (4), 20081876 (2), 15086554 (2), 15492285 (1) (see all 10)
    tarc 57.4 1 15996192 (1)
    glycogen 2.06 1 11997671 (1)
    calcium 0 1 12220670 (1)

    Search CenterWatch for drugs/clinical trials and news about CCR9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for CCR9 gene (3 alternative transcripts): 
    NM_001256369.1  NM_006641.3  NM_031200.2  

    Unigene Cluster for CCR9:

    Chemokine (C-C motif) receptor 9
    Hs.225946  [show with all ESTs]
    Unigene Representative Sequence: NM_001256369
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357632(uc010hiv.2 uc003coz.2 uc003cpa.2) ENST00000395963
    ENST00000463197 ENST00000422395 ENST00000355983
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCR9
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR9:
    hsa-miR-589* hsa-miR-216b
    SwitchGear 3'UTR luciferase reporter plasmidCCR9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCR9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR9
    Clone
    Products:
         
    OriGene clones in human, mouse for CCR9 (see all 12)
    OriGene ORF clones in mouse, rat for CCR9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCR9 (NM_031200)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR9
    Sirion Biotech Customized lentivirus for stable overexpression of CCR9 
                         Customized lentivirus expression plasmids for stable overexpression of CCR9 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCR9
    OriGene qSTAR qPCR primer pairs in human, mouse for CCR9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR9

    Additional mRNA sequence: 

    AF145207.1 AF145439.1 AF145440.1 AJ132337.1 AK312824.1 AK313366.1 BC069678.1 BC095516.1 

    2 DOTS entries:

    DT.70101854  DT.92416571 

    10 AceView cDNA sequences:

    NM_031200 AJ132337 AI926898 AF145207 CF147770 NM_006641 AF145440 BC069678 
    AF145439 AI762921 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCR9 expression in normal human tissues (normalized intensities)      CCR9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGGCAAA
    CCR9 Expression
    About this image


    CCR9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 9 entries
             Small Pre B-Cells Hematopoietic Bone Marrow
             cd4+ cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             Double Positive Thymocytes Thymus
             Thymus   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
             splenocytes   
     
     Lymph (Hematopoietic System)
             lymph node   
     
     Amnion (Extraembryonic Tissues)
             amniotic fluid   

    See CCR9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCR9

    SOURCE GeneReport for Unigene cluster: Hs.225946

    UniProtKB/Swiss-Prot: CCR9_HUMAN, P51686
    Tissue specificity: Highly expressed in the thymus and low in lymph nodes and spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCR9: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCR9
    OriGene qSTAR qPCR primer pairs in human, mouse for CCR9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCR9 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr91 , 5 chemokine (C-C motif) receptor 91, 5 84.73(n)1
    85.64(a)1
      9 (74.33 cM)5
    127691  NM_001166625.11  NP_001160097.11 
     1236784395 
    chicken
    (Gallus gallus)
    Aves CCR91 chemokine (C-C motif) receptor 9 61.86(n)
    52.13(a)
      428454  NM_001045840.1  NP_001039305.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCR96
    Uncharacterized protein
    49(a)
    1 ↔ 1
    GL343324.1(273777-275633)
    zebrafish
    (Danio rerio)
    Actinopterygii ccr9a1 chemokine (C-C motif) receptor 9a 56.62(n)
    46.76(a)
      553366  XM_001343852.1  XP_001343888.1 


    ENSEMBL Gene Tree for CCR9 (if available)
    TreeFam Gene Tree for CCR9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCR9 gene
    CCR62  CCR52  CXCR62  ACKR42  CXCR32  XCR12  CCRL22  CCR72  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/40 SIMAP similar genes for CCR9 using alignment to 3 protein entries:     CCR9_HUMAN (see all proteins) (see all similar genes):
    CCR7    CCR2    CCR-5    CXCR6    CCR5    AGTR1
    CCBP2    BLR1    CCR6    CXCR2    CXCR5    IL8RB
    CCR4    CCR8    CCRL1    CXCR1    CXCR4    CCR3

    CCR9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/545 SNPs in CCR9 are shown (see all 545)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745865491,2
    C,F--45856940(+) CACACC/TGGTGC 3 -- us2k14Minor allele frequency- T:0.31NA CSA WA 242
    rs770391491,2
    F--45856960(+) TTCTCC/TTCTTC 3 -- us2k11Minor allele frequency- T:0.01WA 118
    rs46827981,2
    --45856997(+) CTCCCC/GCGAGA 3 -- us2k1 trp30--------
    rs1900121941,2
    --45857042(+) CTTGTA/GTGCTC 3 -- us2k10--------
    rs1158266131,2
    F--45857287(+) CCAGAG/CCATCT 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1808453281,2
    --45857336(+) ATTTGC/TAATGA 3 -- us2k10--------
    rs2012785231,2
    --45857390(+) GTTCC-/TTTAAG 3 -- us2k10--------
    rs76135481,2
    C,F,A,H--45857466(+) TGTTGG/ACCTTT 3 -- us2k1 tfbs326Minor allele frequency- A:0.40NS EA WA NA CSA 2769
    rs1472167001,2
    C--45857498(+) AAGTGC/TACCTT 3 -- us2k10--------
    rs1175425321,2
    C,F--45857510(+) TGCATC/ACCTTT 3 -- us2k11Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for CCR9 (45927996 - 45944667 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCR9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2462115CNV Insertion19546169
    nsv834678CNV Gain17160897
    nsv876734CNV Gain21882294
    nsv876736CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CCR9
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604738OMIM information: 117360 600644 252350 601869 606658 607135 608448 608982 609299    
    20/27 diseases for CCR9 (see all 27):    About MalaCards
    food allergy    celiac disease    acute graft versus host disease    allergic asthma
    acute lymphocytic leukemia    graft versus host disease    tonsillitis    sjogren's syndrome
    crohn's disease    endometriosis    meningioma    rheumatoid arthritis
    chronic lymphocytic leukemia    inflammatory bowel disease    systemic lupus erythematosus    asthma
    lymphoblastic leukemia    arthritis    lupus erythematosus    pancreatic cancer


    CCR9 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for CCR9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 56.3 5 14559839 (3), 19567201 (1)
    celiac disease 34.8 3 17570212 (2)
    lymphoblastic leukemia acute 22.7 1 19567201 (1)
    metastasis 7.38 10 18245522 (3), 15086554 (3), 19567201 (2), 19756884 (1) (see all 5)
    rheumatoid arthritis 0 1 16207316 (1)
    tumors 0 5 19756884 (2), 18245522 (1)

    Genetic Association Database (GAD): CCR9
    Human Genome Epidemiology (HuGE) Navigator: CCR9 (13 documents)

    Export disorders for CCR9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCR9 gene, integrated from 9 sources (see all 105):
    (articles sorted by number of sources associating them with CCR9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. (PubMed id 10229797)1, 2, 3, 9 Zaballos A.... Marquez G. (1999)
    2. Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. (PubMed id 19525985)1, 4, 9 Inamoto Y....Naoe T. (2010)
    3. CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta- 15 that differ in their sensitivities to ligand. (PubMed id 10640743)1, 2, 9 Yu C.-R.... Farber J.M. (2000)
    4. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    5. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    6. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. CC chemokine receptor 9 enhances proliferation in pan creatic intraepithelial neoplasia and pancreatic cancer cells. (PubMed id 19756884)1, 9 Shen X....Kim J. (2009)
    10. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. (PubMed id 10544196)1, 9 Zabel B.A....Andrew D.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10803 HGNC: 1610 AceView: CCR9 Ensembl:ENSG00000173585 euGenes: HUgn10803
    ECgene: CCR9 Kegg: 10803 H-InvDB: CCR9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCR9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCR9 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCR9 gene:
    Search GeneIP for patents involving CCR9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CCR9
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Purified and/or Recombinant CCR9 Protein
     Browse Small Molecules at EMD Millipore
     EMD Millipore Clones for the Expression of CCR9
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CCR9 (CCR9)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for CCR9 (CCR9)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CCR9   OriGene RNAi products in human, mouse, rat for CCR9  
     OriGene qPCR primer pairs and template standards for CCR9   OriGene Protein Over-expression Lysate for CCR9  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CCR9  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCR9   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CCR9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCR9   OriGene Custom Protein Services for CCR9  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCR9
     QIAGEN SeqTarget long-range PCR primers for resequencing CCR9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR9
     GenScript Custom Purified and Recombinant Proteins Services for CCR9 GenScript cDNA clones with any tag delivered in your preferred vector for CCR9
     GenScript Custom Assay Services for CCR9 GenScript Custom Superior Antibodies Services for CCR9
     GenScript Custom overexpressing Cell Line Services for CCR9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CCR9 promoter
     Search Chromatin IP Primers for CCR9
     RT2 qPCR Primer Assay in human, mouse, rat CCR9
     Search GNC Networks for CCR9
     SABiosciences PCR Arrays including human, mouse, rat CCR9
     Search Tocris compounds for CCR9
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CCR9
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCR9 antibodies
     CCR9 proteins
     CCR9 lysates
     Antibodies for CCR9
     See all of Abcam's Antibodies, Kits and Proteins for CCR9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CCR9
     Antibodies for CCR9
     ELISAs for CCR9
     CLIAs for CCR9
     Search LifeMap BioReagents cell lines for CCR9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR9
     SwitchGear 3'UTR luciferase reporter plasmids for CCR9
     SwitchGear Promoter luciferase reporter plasmids for CCR9
     ThermoFisher Antibodies for CCR9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR9
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCR9
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCR9
    Customized:
     lentivirus for stable overexpression of CCR9
     lentivirus expression plasmids for stable overexpression of CCR9
     adenovirus for overexpression of CCR9
     LSBio Antibodies in human, mouse, rat for CCR9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCR9 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4