Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CCR8 Gene

protein-coding   GIFtS: 64
GCID: GC03P039371

Chemokine (C-C Motif) Receptor 8


(Previous symbols: CMKBRL2, CMKBR8)
  See CCR8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chemokine (C-C Motif) Receptor 81 2     CY62
CMKBR81 2 3 5     C-C Chemokine Receptor Type 82
CMKBRL21 2 3 5     CC Chemokine Receptor 82
CKRL12 3 5     CC-Chemokine Receptor Chemr12
Chemokine Receptor-Like 12 3     Chemokine (C-C) Receptor 82
CC-CKR-82 3     Chemokine (C-C) Receptor-Like 22
CCR-82 3     CKR-L13
GPRCY62 3     GPR-CY63
TER12 3     C-C CKR-83
CC Chemokine Receptor CHEMR12 3     CDw198 Antigen3
CDw1982     

External Ids:    HGNC: 16091   Entrez Gene: 12372   Ensembl: ENSG000001799347   OMIM: 6018345   UniProtKB: P516853   

Export aliases for CCR8 gene to outside databases

Previous GC identifers: GC03P038710 GC03P038604 GC03P039184 GC03P039331 GC03P039346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CCR8 Gene:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane
protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of
various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus.
I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have
been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in
regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to
the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of
lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. (provided by RefSeq, Jul
2008)

GeneCards Summary for CCR8 Gene:
CCR8 (chemokine (C-C motif) receptor 8) is a protein-coding gene. Diseases associated with CCR8 include kaposi's sarcoma, and allergic rhinitis. GO annotations related to this gene include C-C chemokine receptor activity and coreceptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCR8_HUMAN, P51685
Function: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line
apoptosis. Alternative coreceptor with CD4 for HIV-1 infection

summary for CCR8 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCR8 gene promoter:
         AML1a   Pax-2   Pax-2a   GATA-1   AREB6   IRF-2   Pax-2b   FOXC1   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR8 promoter sequence
   Search Chromatin IP Primers for CCR8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p22

CCR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR8 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P039371:  view genomic region     (about GC identifiers)

Start:
39,371,197 bp from pter      End:
39,375,171 bp from pter
Size:
3,975 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CCR8_HUMAN, P51685 (See protein sequence)
Recommended Name: C-C chemokine receptor type 8  
Size: 355 amino acids; 40844 Da
Caution: Was originally (PubMed:9521068) thought to be a receptor for SCYA3 and SCYA17
Secondary accessions: B2RC64 Q3KNQ8 Q9BYX5

Explore the universe of human proteins at neXtProt for CCR8: NX_P51685

Explore proteomics data for CCR8 at MOPED


See CCR8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005192.1  
ENSEMBL proteins: 
 ENSP00000326432   ENSP00000390104   ENSP00000440474  
Reactome Protein details: P51685

CCR8 Human Recombinant Protein Products:

EMD Millipore Purified and/or Recombinant CCR8 Protein
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec
OriGene Custom Protein Services for CCR8
GenScript Custom Purified and Recombinant Proteins Services for CCR8
Novus Biologicals CCR8 Proteins
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CCR8

 
Search eBioscience for Proteins for CCR8 

CCR8 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CCR8
OriGene Antibodies for CCR8
OriGene Custom Antibody Services for CCR8
Novus Biologicals CCR8 Antibodies
Abcam antibodies for CCR8
Cloud-Clone Corp. Antibodies for CCR8
ThermoFisher Antibodies for CCR8
LSBio Antibodies in human, mouse, rat for CCR8

CCR8 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CCR8
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CCR8
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CCR8
Cloud-Clone Corp. CLIAs for CCR8
Search eBioscience for ELISAs for CCR8 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
CD: CD molecules
CCR: GPCR / Class A : Chemokine receptors : C-C motif

IUPHAR Guide to PHARMACOLOGY protein family classification: CCR8
Chemokine receptors

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR004068 Chemokine_CCR8
 IPR000355 Chemokine_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P51685

ProtoNet protein and cluster: P51685

2 Blocks protein domains:
IPB000355 Chemokine receptor signature
IPB004068 C-C chemokine receptor type 8 signature


UniProtKB/Swiss-Prot: CCR8_HUMAN, P51685
Similarity: Belongs to the G-protein coupled receptor 1 family


Find genes that share domains with CCR8           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CCR8_HUMAN, P51685
Function: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line
apoptosis. Alternative coreceptor with CD4 for HIV-1 infection

     Genatlas biochemistry entry for CCR8:
chemokine CC,beta receptor 8,expressed in thymus,spleen and NK cells,G protein coupled receptor superfamily

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity ----
GO:0004950chemokine receptor activity TAS9417093
GO:0005515protein binding ----
GO:0015026coreceptor activity TAS9417093
GO:0016493C-C chemokine receptor activity IEA--
     
Find genes that share ontologies with CCR8           About GenesLikeMe


Phenotypes:
     2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccr8):
 immune system  normal 

Find genes that share phenotypes with CCR8           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for CCR8: Ccr8tm1Lira Ccr8tm1Gma

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR8
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR8

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR8
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR8

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat CCR8 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CCR8
SwitchGear 3'UTR luciferase reporter plasmidCCR8 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CCR8
Predesigned siRNA for gene silencing in human, mouse, rat CCR8

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CCR8

Clone
Products:
     
OriGene clones in human, mouse for CCR8 (see all 5)
OriGene ORF clones in mouse, rat for CCR8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCR8 (NM_005201)
Sino Biological Human cDNA Clone for CCR8
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR8

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CCR8
Browse ESI BIO Cell Lines and PureStem Progenitors for CCR8 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR8


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
CCR8_HUMAN, P51685: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
extracellular1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005887integral component of plasma membrane TAS8816377
GO:0016021integral component of membrane ----

Find genes that share ontologies with CCR8           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for CCR8 About   (see all 11)  
See pathways by source

SuperPathContained pathways About
1Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
G alpha (i) signalling events0.44
GPCR ligand binding0.71
GPCRs, Class A Rhodopsin-like0.43
Peptide ligand-binding receptors0.60
2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
Chemokine receptors bind chemokines0.81
3Neuropeptides signaling through G protein alpha i and G protein alpha q
Peptide GPCRs0.46
Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
4PEDF Induced Signaling
STAT3 Pathway0.47
Cytokine-cytokine receptor interaction0.43
5Chemokine Signaling
Chemokine signaling pathway0.33
Chemokine Signaling0.33


Find genes that share SuperPaths with CCR8           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for CCR8
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR8 (see all 8)
    Chemokine Signaling
STAT3 Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Tec Kinases Signaling

2 BioSystems Pathways for CCR8
    GPCRs, Class A Rhodopsin-like
Peptide GPCRs


2 Reactome Pathways for CCR8
    Chemokine receptors bind chemokines
G alpha (i) signalling events


3 Kegg Pathways  (Kegg details for CCR8):
    Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR8 (see all 6): 
          Innate & Adaptive Immune Responses in human mouse rat
          G Protein Coupled Receptors 384HT in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CCR8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CCR8 (P516853 ENSP000003264324) via UniProtKB, MINT, STRING, and/or I2D (see all 184)
InteractantInteraction Details
GeneCardExternal ID(s)
CCL1P223623, ENSP000002258424I2D: score=2 STRING: ENSP00000225842
CCL16O154673, ENSP000002932754I2D: score=1 STRING: ENSP00000293275
TPST1O605073, ENSP000003024134I2D: score=1 STRING: ENSP00000302413
CCL17Q925833, ENSP000002192444I2D: score=1 STRING: ENSP00000219244
CCL4P132363, ENSP000002501514I2D: score=1 STRING: ENSP00000250151
About this table

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006935chemotaxis IEA--
GO:0006955immune response IEA--
GO:0007155cell adhesion TAS10910894
GO:0007186G-protein coupled receptor signaling pathway TAS8816377
GO:0007204positive regulation of cytosolic calcium ion concentration IEA--

Find genes that share ontologies with CCR8           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Enzo Life Sciences drugs & compounds for CCR8
  Browse compounds at ApexBio 

Compounds for CCR8 available from Tocris Bioscience    About this table
CompoundAction CAS #
RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
MaravirocSelective CCR5 antagonist[376348-65-1]
SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
SB 265610Potent CXCR2 antagonist[211096-49-0]
TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

9 IUPHAR Ligands for CCR8 (CCR8)    About this table
LigandTypeActionAffinityPubmed IDs
vMIP-I
AgonistFull agonist8.9 - 9.910419462 11154210
CCL1
AgonistFull agonist8.5 - 9.811154210 16221874 10419462
[125I]CCL1 (human)
AgonistFull agonist8.9 - 9.79211859 11154210
vMCC-I
AntagonistAntagonist9.410419462
vMIP-II
AntagonistAntagonist8.110419462
ZK 756326
AgonistFull agonist5.716221874
CCL4
AgonistFull agonist5.7--
CCL17
AgonistAgonist5.7--
CCL16
AgonistFull agonist5.7--

5 Novoseek inferred chemical compound relationships for CCR8 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tarc 85.7 19 10540332 (3), 15944327 (2), 11390417 (2), 9521068 (1) (see all 11)
rantes 67.7 5 12393570 (1), 19127964 (1), 11138769 (1), 12009564 (1) (see all 5)
ccl3 61.6 2 11145678 (1), 16365449 (1)
calcium 28.8 15 9469461 (2), 16365449 (2), 11493620 (1), 9211859 (1) (see all 11)
ccl4 22.6 2 19127964 (1), 11145678 (1)



Find genes that share compounds with CCR8           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for CCR8 gene: 
NM_005201.3  

Unigene Cluster for CCR8:

Chemokine (C-C motif) receptor 8
Hs.113222  [show with all ESTs]
Unigene Representative Sequence: NM_005201
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000326306(uc010hhr.2) ENST00000414803 ENST00000545843(uc003cjm.2)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CCR8 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CCR8
SwitchGear 3'UTR luciferase reporter plasmidCCR8 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CCR8
Predesigned siRNA for gene silencing in human, mouse, rat CCR8
Clone
Products:
     
OriGene clones in human, mouse for CCR8 (see all 5)
OriGene ORF clones in mouse, rat for CCR8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CCR8 (NM_005201)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR8
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR8
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CCR8
OriGene qSTAR qPCR primer pairs in human, mouse for CCR8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCR8
  QuantiTect SYBR Green Assays in human, mouse, rat CCR8
  QuantiFast Probe-based Assays in human, mouse, rat CCR8

Additional mRNA sequence: 

AF005210.1 AK314957.1 BC069067.1 BC074743.2 BC107152.2 BC107159.1 D49919.1 

2 DOTS entries:

DT.91948348  DT.102821218 

14 AceView cDNA sequences:

AF005210 BC069067 BC074743 CN841483 NM_005201 CN839535 AI206322 CN831404 
CN841472 CN841188 D49919 CN839563 CN841238 CN831628 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CCR8    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:                              
SP2:                              


ECgene alternative splicing isoforms for CCR8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

CCR8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTGGCACAA
CCR8 Expression
About this image


CCR8 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Thymus (Hematopoietic System)
         Thymus
CCR8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCR8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.113222
    Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR8 (see all 6): 
          Innate & Adaptive Immune Responses in human mouse rat
          G Protein Coupled Receptors 384HT in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Chemokines & Receptors in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CCR8
OriGene qSTAR qPCR primer pairs in human, mouse for CCR8
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCR8
QuantiTect SYBR Green Assays in human, mouse, rat CCR8
QuantiFast Probe-based Assays in human, mouse, rat CCR8
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR8

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for CCR8 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ccr81 , 5 chemokine (C-C motif) receptor 81, 5 76.02(n)1
71.39(a)1
  9 (71.39 cM)5
127761  NM_007720.21  NP_031746.11 
 1200921335 
chicken
(Gallus gallus)
Aves CCR8L1 C-C chemokine receptor 8 like 60.34(n)
53.38(a)
  776400  NM_001080894.1  NP_001074363.1 
zebrafish
(Danio rerio)
Actinopterygii ccr8.16
BX537113.16
(see all 6)
Uncharacterized protein
(see all 6)
34(a)
34(a)
(see all 6)
many ↔ many
many ↔ many
(see all 6)
16(11002252-11005272) ENSDARG00000032826
16(9973995-9980180) ENSDARG00000062999


ENSEMBL Gene Tree for CCR8 (if available)
TreeFam Gene Tree for CCR8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for CCR8 gene
CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
CCR72  ACKR22  CX3CR12  CXCR22  CCR12  CCR42  CXCR12  CCR22  
CXCR52  CCR102  CCR32  CXCR42  
Selected SIMAP similar genes for CCR8 using alignment to 3 protein entries:     CCR8_HUMAN (see all proteins) (see all similar genes):
CCR2    CCR-5    CX3CR1    CCR1    CCR5    CCR4
CCR3    BLR1    CXCR2    CXCR5    IL8RB    XCR1
CCR6    BDKRB2    DKFZp686O088    CCR7    CCR9    SSTR1

Find genes that share paralogs with CCR8           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for CCR8 (see all 157)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1478350011,2
--39369255(+) ATCTGA/GCTCAG 1 -- us2k10--------
rs1891401701,2
C--39369258(+) TGGCTC/TAGGAA 1 -- us2k10--------
rs18750901,2
C,F,H--39369259(-) TTTCCC/TGAGCC 1 -- us2k112Minor allele frequency- T:0.06NA WA CSA EA 377
rs1413320421,2
--39369587(+) TGAGGC/TGGTCC 1 -- us2k10--------
rs121075271,2
C,F,H--39369682(+) ACATAC/TAAAAC 1 -- us2k115Minor allele frequency- T:0.17NS EA NA WA 1892
rs1144171601,2
C,F--39369844(+) AACTGC/GTGGAC 1 -- us2k12Minor allele frequency- G:0.03NA EA 240
rs1818400651,2
--39369851(+) GGACTC/TAAGTG 1 -- us2k10--------
rs98146191,2
C,F--39369900(+) AGTGCA/CTGCCA 1 -- us2k14Minor allele frequency- C:0.28NA 126
rs558361561,2
C,F--39369912(+) CATGCC/TTGGCT 1 -- us2k14Minor allele frequency- T:0.21NA WA 242
rs76472541,2
C,F,H--39369947(+) gatgaT/Cgcatt 1 -- us2k115Minor allele frequency- C:0.08NS EA NA 1988

HapMap Linkage Disequilibrium report for CCR8 (39371197 - 39375171 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CCR8:    About this table    
Variant IDTypeSubtypePubMed ID
nsv518801CNV Loss19592680
nsv460509CNV Loss19166990
esv29441CNV Loss19812545

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CCR8
DNA2.0 Custom Variant and Variant Library Synthesis for CCR8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 601834    OMIM disorders: --

2 diseases for CCR8:    
About MalaCards
kaposi's sarcoma    allergic rhinitis

2 diseases from the University of Copenhagen DISEASES database for CCR8:
Asthma     Molluscum contagiosum

Find genes that share disorders with CCR8           About GenesLikeMe

Selected Novoseek inferred disease relationships for CCR8 gene (see all 19)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
molluscum contagiosum 51 4 11493620 (2), 10620615 (1)
immunodeficiency 43.7 5 10888633 (2), 9417093 (1), 16221874 (1), 9765485 (1)
kaposi sarcoma 39.1 1 11133740 (1)
airways disease 36.6 1 12901955 (1)
inflammation 31.2 15 12009564 (2), 17014623 (1), 17641040 (1), 19208087 (1) (see all 9)
asthma 29.2 8 16640325 (1), 18218997 (1), 18684970 (1), 18672380 (1) (see all 6)
allergic rhinitis 26.1 1 16623955 (1)
herpes 22.6 1 9834206 (1)
hiv infections 22.3 3 16221874 (1), 12551893 (1)
pulmonary disease chronic obstructive 17.3 1 11390417 (1)

Genetic Association Database (GAD): CCR8
Human Genome Epidemiology (HuGE) Navigator: CCR8 (6 documents)

Export disorders for CCR8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for CCR8 gene, integrated from 10 sources (see all 185):
(articles sorted by number of sources associating them with CCR8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. (PubMed id 8816377)1, 2, 3, 9 Napolitano M.... Santoni A. (J. Immunol. 1996)
  2. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. (PubMed id 8886020)1, 2, 3, 9 Zaballos A.... Marquez G. (Biochem. Biophys. Res. Commun. 1996)
  3. Identification of CCR8 as the specific receptor for the human beta- chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. (PubMed id 9469461)1, 2, 9 Goya I.... Marquez G. (J. Immunol. 1998)
  4. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PubMed id 10540332)1, 2, 9 Garlisi C.G....Umland S.P. (Eur. J. Immunol. 1999)
  5. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PubMed id 9521068)1, 2, 9 Bernardini G....Napolitano M. (Eur. J. Immunol. 1998)
  6. Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. (PubMed id 12551893)1, 2, 9 DeVries M.E.... Kelvin D.J. (J. Biol. Chem. 2003)
  7. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. (PubMed id 9207005)1, 2, 9 Tiffany H.L.... Murphy P.M. (J. Exp. Med. 1997)
  8. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
  9. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
  10. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 1237 HGNC: 1609 AceView: CCR8 Ensembl:ENSG00000179934 euGenes: HUgn1237
ECgene: CCR8 Kegg: 1237 H-InvDB: CCR8

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for CCR8 Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for CCR8 gene:
Search GeneIP for patents involving CCR8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 Browse Small Molecules at EMD Millipore
 EMD Millipore Purified and/or Recombinant CCR8 Protein
 Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
 Browse Kits and Assays available from EMD Millipore
 
 EMD Millipore genomic analysis products

  
 Antibodies for CCR8 (CCR8)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 cDNA Clones for CCR8 (CCR8)   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for CCR8   OriGene RNAi products in human, mouse, rat for CCR8  
 OriGene qPCR primer pairs and template standards for CCR8   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for CCR8  
 OriGene qSTAR qPCR primer pairs in human, mouse for CCR8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for CCR8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CCR8   OriGene Custom Protein Services for CCR8  

 
 
 Block miRNA regulation of human, mouse, rat CCR8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCR8
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR8 Predesigned siRNA for gene silencing in human, mouse, rat CCR8
 QuantiFast Probe-based Assays in human, mouse, rat CCR8 QuantiTect SYBR Green Assays in human, mouse, rat CCR8
 PCR Arrays including human, mouse, rat CCR8 Search Chromatin IP Primers for CCR8
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCR8  GeneGlobe Interaction Network for CCR8
 Regulatory tfbs in CCR8 promoter
 GenScript Custom Purified and Recombinant Proteins Services for CCR8 GenScript cDNA clones with any tag delivered in your preferred vector for CCR8
 GenScript Custom Assay Services for CCR8 GenScript Custom overexpressing Cell Line Services for CCR8
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Tocris compounds for CCR8
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 cDNA Clones for CCR8
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Drugs for CCR8
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 CCR8 antibodies
 CCR8 proteins
 Antibodies for CCR8
 See all of Abcam's Antibodies, Kits and Proteins for CCR8
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for CCR8
 Antibodies for CCR8
 ELISAs for CCR8
 CLIAs for CCR8



 Browse ESI BIO Cell Lines and PureStem Progenitors for CCR8
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR8
 SwitchGear 3'UTR luciferase reporter plasmids for CCR8
 SwitchGear Promoter luciferase reporter plasmids for CCR8
 ThermoFisher Antibodies for CCR8
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR8
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR8
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR8
 LSBio Antibodies in human, mouse, rat for CCR8
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for CCR8
  Search eBioscience for proteins for CCR8
  Search eBioscience for elisas for CCR8
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      CCR8 gene at Home site.
Version: 3.12.212 17 Sep 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4