CCR8 Gene
protein-coding GIFtS: 64
GCID: GC03P039371
|
|
chemokine (C-C motif) receptor 8
(Previous symbols: CMKBRL2, CMKBR8)
| |
Aliases
for CCR8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chemokine (C-C Motif) Receptor 81 2 | | CCR-82 3 | | CMKBR81 2 3 5 | | GPRCY62 3 | | CMKBRL21 2 3 5 | | CC Chemokine Receptor CHEMR12 3 | | TER11 2 3 | | C-C Chemokine Receptor Type 82 | | CKRL12 3 5 | | CC Chemokine Receptor 82 | | CDw1981 2 | | CC-Chemokine Receptor Chemr12 | | CY61 2 | | Chemokine (C-C) Receptor 82 | | CKR-L11 3 | | Chemokine (C-C) Receptor-Like 22 | | GPR-CY61 3 | | C-C CKR-83 | | Chemokine Receptor-Like 12 3 | | CDw198 Antigen3 | | CC-CKR-82 3 | | |
Export aliases for CCR8 gene to outside databasesPrevious GC identifers: GC03P038710 GC03P038604 GC03P039184 GC03P039331 GC03P039346 |
Summaries
for CCR8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCR8:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembraneprotein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration ofvarious cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309,thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have beenidentified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation ofmonocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the properpositioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. Thisgene is located at the chemokine receptor gene cluster region. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CCR8_HUMAN, P51685Function: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis.Alternative coreceptor with CD4 for HIV-1 infection
 summary
for CCR8: Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.
Gene Wiki entry for CCR8
|
Genomic Views
for CCR8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCR8 gene promoter:
AML1a Pax-2 Pax-2a GATA-1 AREB6 IRF-2 Pax-2b FOXC1 NF-kappaB1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCR8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p22 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p22CCR8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P039371: view genomic region
(about GC identifiers)
Start:
|
39,371,197 bp from pter |
End:
|
39,375,171 bp from pter |
Size:
|
3,975 bases |
Orientation:
|
plus strand |
|
Proteins
for CCR8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCR8_HUMAN, P51685 (See
protein sequence)Recommended Name: C-C chemokine receptor type 8 Size: 355 amino acids; 40844 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Was originally (PubMed:9521068) thought to be a receptor for SCYA3 and SCYA17
Secondary accessions: B2RC64 Q3KNQ8 Q9BYX5Explore the universe of human proteins at neXtProt for CCR8: NX_P51685
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51685
CCR8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005192.1
ENSEMBL proteins: ENSP00000326432 ENSP00000390104 ENSP00000440474 Reactome Protein details: P51685
Human Recombinant Protein Products for CCR8:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CCR8 for ontologies About GeneDecksing
CCR8 Antibody Products:
Assay Products for CCR8: |
Protein
Domains /
Families
for CCR8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCR8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51685ProtoNet protein and cluster: P51685 2 Blocks protein families: IPB000355 Chemokine receptor signature IPB004068 C-C chemokine receptor type 8 signature
UniProtKB/Swiss-Prot: CCR8_HUMAN, P51685Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for CCR8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CCR8_HUMAN, P51685Function: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis.Alternative coreceptor with CD4 for HIV-1 infection Genatlas biochemistry entry for CCR8:chemokine CC,beta receptor 8,expressed in thymus,spleen and NK cells,G protein coupled receptor superfamily
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CCR8 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ccr8):
CCR8 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for CCR8: Ccr8tm1Lira Ccr8tm1Gma
Clone
Products: |  | EMD Millipore Clones for the Expression of CCR8 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCR8 (NM_005201) | |  | Sino Biological Human cDNA Clone for CCR8 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCR8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR8 |
|
Pathways & Interactions
for CCR8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Akt Signaling | | | 3 | Signaling by GPCR | | | 4 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | | | 5 | Chemokine Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CCR8
5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR8 (see all 8)
2  BioSystems Pathways for CCR8
5/8 
Reactome Pathways for CCR8 (see all 8)
2 
Kegg Pathways (Kegg details for CCR8):
CCR8 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCR8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/184 Interacting proteins for CCR8 (P516853 ENSP000003264324) via UniProtKB, MINT, STRING, and/or I2D (see all 184)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
CCR8 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCR8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CCR8 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for CCR8 |
Compounds for CCR8 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| ZK 756326 | Selective, non-peptide CCR8 agonist | [874911-96-3] |
5 Novoseek chemical compound relationships for CCR8 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tarc |
85.7 |
19 |
10540332 (3), 15944327 (2), 11390417 (2), 9521068 (1) (see all 11) |
| rantes |
67.7 |
5 |
12393570 (1), 19127964 (1), 11138769 (1), 12009564 (1) (see all 5) |
| ccl3 |
61.6 |
2 |
11145678 (1), 16365449 (1) |
| calcium |
28.8 |
15 |
9469461 (2), 16365449 (2), 11493620 (1), 9211859 (1) (see all 11) |
| ccl4 |
22.6 |
2 |
19127964 (1), 11145678 (1) |
Search CenterWatch for drugs/clinical trials and news about CCR8
|
Transcripts
for CCR8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCR8 gene: NM_005201.3 Unigene Cluster for CCR8: Chemokine (C-C motif) receptor 8 Hs.113222 [show with all ESTs]Unigene Representative Sequence: NM_0052013 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326306(uc010hhr.2) ENST00000414803 ENST00000545843(uc003cjm.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCR8 (NM_005201) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCR8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR8 |
Additional cDNA sequence: AF005210.1 AK314957.1 BC069067.1 BC074743.2 BC107152.2 BC107159.1 D49919.1 2 DOTS entries: DT.91948348 DT.102821218 14 AceView cDNA sequences: BC069067 BC074743 AF005210 CN831404 CN841188 AI206322 NM_005201 CN839535 CN841472 CN841483 D49919 CN839563 CN841238 CN831628
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CCR8 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for CCR8
|
Expression
for CCR8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCR8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGCACAA
About this image
See CCR8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCR8
SOURCE GeneReport for Unigene cluster: Hs.113222
SABiosciences Expression via Pathway-Focused PCR Arrays including CCR8 (see all 6):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR8 |
Orthologs
for CCR8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCR8 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for CCR8 (if available)
TreeFam Gene Tree for CCR8 (if available) |
Paralogs
for CCR8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCR8 gene
- CCR62 CCR52 CXCR62 CXCR32 XCR12 CCR92 CCBP22 CCRL22
- CCR72 CX3CR12 CXCR22 CCRL12 CCR42 CCR12 CXCR12 CCR22
- CXCR52 CCR102 CCR32 CXCR42
18/53 SIMAP similar genes for CCR8 using alignment to 3 protein entries: CCR8_HUMAN (see all proteins)
(see all similar genes):CCR2 CCR-5 CX3CR1 CCR1 CCR5 CCR4
CCR3 BLR1 CXCR2 CXCR5 IL8RB XCR1
CCR6 BDKRB2 DKFZp686O088 CCR7 CCR9 SSTR1
CCR8 for paralogs About GeneDecksing
|
Genomic Variants
for CCR8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCR8 (39371197 - 39375171 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CCR8
2 CNVs: 91286 63449 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR8 |
|
Disorders
/ Diseases
for CCR8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCR8 for disorders About GeneDecksing
OMIM gene information: 601834
OMIM disorders: --
20/28  diseases for CCR8 (see all 28): About MalaCardsmolluscum contagiosum b-cell non-hodgkin lymphoma hematopoiesis non-hodgkin lymphoma
allergic rhinitis chronic obstructive pulmonary disease hodgkin's lymphoma kaposi's sarcoma
malt lymphoma rhinitis chronic lymphocytic leukemia pulmonary disease
lymphocytic leukemia cutaneous t cell lymphoma sarcoma adenoiditis
hepatitis b encephalomyelitis asthma meningitis
2 diseases from the University of Copenhagen DISEASES database for CCR8:Molluscum contagiosum Asthma 10/19 Novoseek disease relationships for CCR8 gene (see all 19) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| molluscum contagiosum |
51 |
4 |
11493620 (2), 10620615 (1) |
| immunodeficiency |
43.7 |
5 |
10888633 (2), 9417093 (1), 16221874 (1), 9765485 (1) |
| kaposi sarcoma |
39.1 |
1 |
11133740 (1) |
| airways disease |
36.6 |
1 |
12901955 (1) |
| inflammation |
31.2 |
15 |
12009564 (2), 17014623 (1), 17641040 (1), 19208087 (1) (see all 9) |
| asthma |
29.2 |
8 |
16640325 (1), 18218997 (1), 18684970 (1), 18672380 (1) (see all 6) |
| allergic rhinitis |
26.1 |
1 |
16623955 (1) |
| herpes |
22.6 |
1 |
9834206 (1) |
| hiv infections |
22.3 |
3 |
16221874 (1), 12551893 (1) |
| pulmonary disease chronic obstructive |
17.3 |
1 |
11390417 (1) |
Human Genome Epidemiology (HuGE) Navigator: CCR8 (6 documents)
Export disorders for CCR8 gene to outside databases
|
Publications
for CCR8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCR8 gene, integrated from 9 sources (see all 183):
(articles sorted by number of sources associating them with CCR8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. (PubMed id 8816377)1, 2, 3, 9 Napolitano M.... Santoni A. (1996)
- Molecular cloning and RNA expression of two new human chemokine receptor-like genes. (PubMed id 8886020)1, 2, 3, 9 Zaballos A.... Marquez G. (1996)
- Identification of CCR8 as the specific receptor for the human beta- chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. (PubMed id 9469461)1, 2, 9 Goya I.... Marquez G. (1998)
- The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PubMed id 10540332)1, 2, 9 Garlisi C.G....Umland S.P. (1999)
- Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PubMed id 9521068)1, 2, 9 Bernardini G....Napolitano M. (1998)
- Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. (PubMed id 12551893)1, 2, 9 DeVries M.E.... Kelvin D.J. (2003)
- Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. (PubMed id 9207005)1, 2, 9 Tiffany H.L.... Murphy P.M. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor. (PubMed id 8977299)1, 2 Samson M....Parmentier M. (1996)
- Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. (PubMed id 14576057)1, 9 Haque N.S....Harpel P.C. (2004)
|
External Searches for CCR8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCR8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCR8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCR8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCR8 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/CC_chemokine_receptors |
|
| | |
About This Section
| Patent Information for CCR8 gene:
Search GeneIP for patents involving CCR8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCR8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for CCR8 | | OriGene shRNA RFP for CCR8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCR8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCR8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCR8 | | OriGene Custom Protein Services for CCR8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCR8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR8 |
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| | | | Tocris compounds for CCR8 |
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 | | | CCR8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR8 |
|  |  |  |  | | | | ThermoFisher Antibodies for CCR8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR8 |
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