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Aliases for CCR8 Gene

Aliases for CCR8 Gene

  • Chemokine (C-C Motif) Receptor 8 2 3
  • CMKBRL2 3 4 6
  • CMKBR8 3 4 6
  • CKRL1 3 4 6
  • CC Chemokine Receptor CHEMR1 3 4
  • Chemokine Receptor-Like 1 3 4
  • CC-CKR-8 3 4
  • GPRCY6 3 4
  • CCR-8 3 4
  • TER1 3 4
  • Chemokine (C-C) Receptor-Like 2 3
  • C-C Chemokine Receptor Type 8 3
  • CC-Chemokine Receptor Chemr1 3
  • Chemokine (C-C) Receptor 8 3
  • CC Chemokine Receptor 8 3
  • CDw198 Antigen 4
  • C-C CKR-8 4
  • GPR-CY6 4
  • CDw198 3
  • CKR-L1 4
  • CY6 3

External Ids for CCR8 Gene

Previous HGNC Symbols for CCR8 Gene

  • CMKBR8

Previous GeneCards Identifiers for CCR8 Gene

  • GC03P038710
  • GC03P038604
  • GC03P039184
  • GC03P039331
  • GC03P039346
  • GC03P039371

Summaries for CCR8 Gene

Entrez Gene Summary for CCR8 Gene

  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR8 Gene

CCR8 (Chemokine (C-C Motif) Receptor 8) is a Protein Coding gene. Diseases associated with CCR8 include kaposi sarcoma and allergic rhinitis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include coreceptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR8 Gene

  • Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.

Tocris Summary for CCR8 Gene

  • Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorised into four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are classified according to the class of chemokines that they bind. The major function of chemokines is to regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR8 Gene

Genomics for CCR8 Gene

Regulatory Elements for CCR8 Gene

Genomic Location for CCR8 Gene

39,329,706 bp from pter
39,333,680 bp from pter
3,975 bases
Plus strand

Genomic View for CCR8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR8 Gene

Proteins for CCR8 Gene

  • Protein details for CCR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-C chemokine receptor type 8
    Protein Accession:
    Secondary Accessions:
    • B2RC64
    • Q3KNQ8
    • Q3KNR3
    • Q9BYX5

    Protein attributes for CCR8 Gene

    355 amino acids
    Molecular mass:
    40844 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCR8 Gene


neXtProt entry for CCR8 Gene

Proteomics data for CCR8 Gene at MOPED

Post-translational modifications for CCR8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCR8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCR8 Gene

Domains for CCR8 Gene

Gene Families for CCR8 Gene

  • CD :CD molecules
  • CCR :GPCR / Class A : Chemokine receptors : C-C motif

Suggested Antigen Peptide Sequences for CCR8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P51685
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR8: view

Function for CCR8 Gene

Molecular function for CCR8 Gene

GENATLAS Biochemistry:
chemokine CC,beta receptor 8,expressed in thymus,spleen and NK cells,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.

Gene Ontology (GO) - Molecular Function for CCR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 9417093
GO:0005515 protein binding --
GO:0015026 coreceptor activity TAS 9417093
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR8: view

Phenotypes for CCR8 Gene

genes like me logo Genes that share phenotypes with CCR8: view

Animal Models for CCR8 Gene

MGI Knock Outs for CCR8:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CCR8 Gene

Localization for CCR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CCR8 Gene COMPARTMENTS Subcellular localization image for CCR8 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CCR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8816377
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CCR8: view

Pathways for CCR8 Gene

genes like me logo Genes that share pathways with CCR8: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006955 immune response IEA --
GO:0007155 cell adhesion TAS 10910894
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with CCR8: view

Compounds for CCR8 Gene

(5) Tocris Compounds for CCR8 Gene

Compound Action Cas Number
AMD 3100 octahydrochloride Highly selective CXCR4 antagonist [155148-31-5]
AMD 3465 hexahydrobromide Potent, selective CXCR4 antagonist [185991-07-5]
RS 504393 Highly selective CCR2 chemokine receptor antagonist [300816-15-3]
SB 225002 Potent and selective CXCR2 antagonist [182498-32-4]
SB 328437 Potent and selective CCR3 antagonist [247580-43-4]

(9) IUPHAR Ligand for CCR8 Gene

Ligand Type Action Affinity Pubmed IDs
vMIP-I Agonist Full agonist 9.9
CCL1 Agonist Full agonist 9.8
[125I]CCL1 (human) Agonist Full agonist 9.7
vMCC-I Antagonist Antagonist 9.4
vMIP-II Antagonist Antagonist 8.1
CCL16 Agonist Full agonist 8.1
CCL4 Antagonist Antagonist 7.8
ZK 756326 Agonist Full agonist 5.7
CCL17 Agonist Agonist

(5) Novoseek inferred chemical compound relationships for CCR8 Gene

Compound -log(P) Hits PubMed IDs
tarc 85.7 15
rantes 67.7 5
ccl3 61.6 2
calcium 28.8 13
ccl4 22.6 2
genes like me logo Genes that share compounds with CCR8: view

Transcripts for CCR8 Gene

mRNA/cDNA for CCR8 Gene

(14) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCR8 Gene

Chemokine (C-C motif) receptor 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b

Relevant External Links for CCR8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCR8 Gene

mRNA expression in normal human tissues for CCR8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CCR8 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCR8 Gene

SOURCE GeneReport for Unigene cluster for CCR8 Gene Hs.113222

genes like me logo Genes that share expressions with CCR8: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCR8 Gene

Orthologs for CCR8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCR8 35
  • 82.86 (n)
  • 81.82 (a)
CCR8 36
  • 82 (a)
(Canis familiaris)
Mammalia CCR8 35
  • 85.45 (n)
  • 82.25 (a)
CCR8 36
  • 82 (a)
(Mus musculus)
Mammalia Ccr8 35
  • 76.02 (n)
  • 71.39 (a)
Ccr8 16
Ccr8 36
  • 71 (a)
(Pan troglodytes)
Mammalia CCR8 35
  • 99.44 (n)
  • 99.44 (a)
CCR8 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ccr8 35
  • 76.11 (n)
  • 71.95 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
-- 36
  • 65 (a)
(Gallus gallus)
Aves CCR8L 35
  • 60.34 (n)
  • 53.38 (a)
CCR8 36
  • 46 (a)
CCR8L 36
  • 45 (a)
(Danio rerio)
Actinopterygii BX511173.1 36
  • 32 (a)
BX537113.1 36
  • 33 (a)
BX537113.1 36
  • 34 (a)
CABZ01093075.1 36
  • 32 (a)
ccr8.1 36
  • 34 (a)
ccr8.1 36
  • 34 (a)
Species with no ortholog for CCR8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR8 Gene

Gene Tree for CCR8 (if available)
Gene Tree for CCR8 (if available)

Paralogs for CCR8 Gene

genes like me logo Genes that share paralogs with CCR8: view

Variants for CCR8 Gene

Sequence variations from dbSNP and Humsavar for CCR8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1317601 -- 39,327,754(-) TCTGA(C/G)GGCTG upstream-variant-2KB
rs1875090 -- 39,327,768(-) TTTCC(C/T)GAGCC upstream-variant-2KB
rs2088668 -- 39,333,924(-) aatgc(A/G)tgctg downstream-variant-500B
rs2102047 -- 39,334,140(-) TATAT(A/T)TTATT downstream-variant-500B
rs2102048 -- 39,334,137(-) atttt(A/T)tttta downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CCR8 Gene

Variant ID Type Subtype PubMed ID
nsv518801 CNV Loss 19592680
esv29441 CNV Loss 19812545
nsv460509 CNV Loss 19166990

Relevant External Links for CCR8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR8 Gene

Disorders for CCR8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CCR8 Gene in MalaCards »

(2) Diseases for CCR8 Gene including...

(2) University of Copenhagen DISEASES for CCR8 Gene

(19) Novoseek inferred disease relationships for CCR8 Gene

Disease -log(P) Hits PubMed IDs
molluscum contagiosum 51 3
immunodeficiency 43.7 5
kaposi sarcoma 39.1 1
airways disease 36.6 1
inflammation 31.2 10

Relevant External Links for CCR8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CCR8: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CCR8 Gene

Publications for CCR8 Gene

  1. Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. (PMID: 8816377) Napolitano M. … Santoni A. (J. Immunol. 1996) 2 3 4 23
  2. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. (PMID: 8886020) Zaballos A. … Marquez G. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  3. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. (PMID: 9207005) Tiffany H.L. … Murphy P.M. (J. Exp. Med. 1997) 3 4 23
  4. Identification of CCR8 as the specific receptor for the human beta- chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. (PMID: 9469461) Goya I. … Marquez G. (J. Immunol. 1998) 3 4 23
  5. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PMID: 9521068) Bernardini G. … Napolitano M. (Eur. J. Immunol. 1998) 3 4 23

Products for CCR8 Gene

Sources for CCR8 Gene

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