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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCR8 Gene

protein-coding   GIFtS: 65
GCID: GC03P039371

Chemokine (C-C Motif) Receptor 8


(Previous symbols: CMKBRL2, CMKBR8)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Receptor 81 2     CY62
CMKBR81 2 3 5     C-C Chemokine Receptor Type 82
CMKBRL21 2 3 5     CC Chemokine Receptor 82
CKRL12 3 5     CC-Chemokine Receptor Chemr12
Chemokine Receptor-Like 12 3     Chemokine (C-C) Receptor 82
CC-CKR-82 3     Chemokine (C-C) Receptor-Like 22
CCR-82 3     CKR-L13
GPRCY62 3     GPR-CY63
TER12 3     C-C CKR-83
CC Chemokine Receptor CHEMR12 3     CDw198 Antigen3
CDw1982     

External Ids:    HGNC: 16091   Entrez Gene: 12372   Ensembl: ENSG000001799347   OMIM: 6018345   UniProtKB: P516853   

Export aliases for CCR8 gene to outside databases

Previous GC identifers: GC03P038710 GC03P038604 GC03P039184 GC03P039331 GC03P039346


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCR8 Gene:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane
protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of
various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus.
I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have
been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in
regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to
the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of
lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. (provided by RefSeq, Jul
2008)

GeneCards Summary for CCR8 Gene: 
CCR8 (chemokine (C-C motif) receptor 8) is a protein-coding gene. Diseases associated with CCR8 include molluscum contagiosum, and kaposi's sarcoma, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Peptide GPCRs. GO annotations related to this gene include C-C chemokine receptor activity and coreceptor activity. An important paralog of this gene is CCR6.

UniProtKB/Swiss-Prot: CCR8_HUMAN, P51685
Function: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line
apoptosis. Alternative coreceptor with CD4 for HIV-1 infection

summary for CCR8 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCR8 gene promoter:
         AML1a   Pax-2   Pax-2a   GATA-1   AREB6   IRF-2   Pax-2b   FOXC1   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR8 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCR8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p22

CCR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR8 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P039371:  view genomic region     (about GC identifiers)

Start:
39,371,197 bp from pter      End:
39,375,171 bp from pter
Size:
3,975 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCR8_HUMAN, P51685 (See protein sequence)
Recommended Name: C-C chemokine receptor type 8  
Size: 355 amino acids; 40844 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Was originally (PubMed:9521068) thought to be a receptor for SCYA3 and SCYA17
Secondary accessions: B2RC64 Q3KNQ8 Q9BYX5

Explore the universe of human proteins at neXtProt for CCR8: NX_P51685

Explore proteomics data for CCR8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51685

  • CCR8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCR8 Protein Expression
    REFSEQ proteins: NP_005192.1  
    ENSEMBL proteins: 
     ENSP00000326432   ENSP00000390104   ENSP00000440474  
    Reactome Protein details: P51685
    Human Recombinant Protein Products for CCR8: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCR8 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8816377
    GO:0016021integral to membrane ----

    CCR8 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CCR8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR8 
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004068 Chemokine_CCR8
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P51685

    ProtoNet protein and cluster: P51685

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB004068 C-C chemokine receptor type 8 signature


    UniProtKB/Swiss-Prot: CCR8_HUMAN, P51685
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CCR8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR8_HUMAN, P51685
    Function: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line
    apoptosis. Alternative coreceptor with CD4 for HIV-1 infection

         Genatlas biochemistry entry for CCR8:
    chemokine CC,beta receptor 8,expressed in thymus,spleen and NK cells,G protein coupled receptor superfamily

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS9417093
    GO:0005515protein binding ----
    GO:0015026coreceptor activity TAS9417093
    GO:0016493C-C chemokine receptor activity IEA--
         
    CCR8 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccr8):
     immune system  normal 

    CCR8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CCR8: Ccr8tm1Lira Ccr8tm1Gma

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCR8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCR8

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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCR8 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    3PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    4Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCR8
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR8 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 BioSystems Pathways for CCR8
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    5/8        Reactome Pathways for CCR8 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CCR8):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Viral carcinogenesis


    CCR8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCR8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/184 Interacting proteins for CCR8 (P516853 ENSP000003264324) via UniProtKB, MINT, STRING, and/or I2D (see all 184)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL1P223623, ENSP000002258424I2D: score=2 STRING: ENSP00000225842
    CCL16O154673, ENSP000002932754I2D: score=1 STRING: ENSP00000293275
    TPST1O605073, ENSP000003024134I2D: score=1 STRING: ENSP00000302413
    CCL17Q925833, ENSP000002192444I2D: score=1 STRING: ENSP00000219244
    CCL4P132363, ENSP000002501514I2D: score=1 STRING: ENSP00000250151
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006955immune response IEA--
    GO:0007155cell adhesion TAS10910894
    GO:0007186G-protein coupled receptor signaling pathway TAS8816377
    GO:0007204elevation of cytosolic calcium ion concentration IEA--

    CCR8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCR8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CCR8

    Compounds for CCR8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    9 IUPHAR Ligands for CCR8 (CCR8)    About this table 
    LigandTypeActionAffinityPubmed IDs
    vMIP-I
    AgonistFull agonist8.9 - 9.910419462 11154210
    CCL1
    AgonistFull agonist8.5 - 9.811154210 16221874 10419462
    [125I]CCL1 (human)
    AgonistFull agonist8.9 - 9.79211859 11154210
    vMCC-I
    AntagonistAntagonist9.410419462
    vMIP-II
    AntagonistAntagonist8.110419462
    ZK 756326
    AgonistFull agonist5.716221874
    CCL4
    AgonistFull agonist5.7--
    CCL17
    AgonistAgonist5.7--
    CCL16
    AgonistFull agonist5.7--

    5 Novoseek inferred chemical compound relationships for CCR8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 85.7 19 10540332 (3), 15944327 (2), 11390417 (2), 9521068 (1) (see all 11)
    rantes 67.7 5 12393570 (1), 19127964 (1), 11138769 (1), 12009564 (1) (see all 5)
    ccl3 61.6 2 11145678 (1), 16365449 (1)
    calcium 28.8 15 9469461 (2), 16365449 (2), 11493620 (1), 9211859 (1) (see all 11)
    ccl4 22.6 2 19127964 (1), 11145678 (1)

    Search CenterWatch for drugs/clinical trials and news about CCR8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCR8 gene: 
    NM_005201.3  

    Unigene Cluster for CCR8:

    Chemokine (C-C motif) receptor 8
    Hs.113222  [show with all ESTs]
    Unigene Representative Sequence: NM_005201
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326306(uc010hhr.2) ENST00000414803 ENST00000545843(uc003cjm.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF005210.1 AK314957.1 BC069067.1 BC074743.2 BC107152.2 BC107159.1 D49919.1 

    2 DOTS entries:

    DT.91948348  DT.102821218 

    14 AceView cDNA sequences:

    BC069067 AF005210 BC074743 NM_005201 CN841483 CN831404 AI206322 CN841472 
    CN841188 CN839535 D49919 CN839563 CN841238 CN831628 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCR8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for CCR8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCR8 expression in normal human tissues (normalized intensities)      CCR8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCACAA
    CCR8 Expression
    About this image


    CCR8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Thymus (Hematopoietic System)
             Thymus

    See CCR8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCR8

    SOURCE GeneReport for Unigene cluster: Hs.113222
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCR8 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCR8 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr81 , 5 chemokine (C-C motif) receptor 81, 5 76.02(n)1
    71.39(a)1
      9 (71.39 cM)5
    127761  NM_007720.21  NP_031746.11 
     1200921335 
    chicken
    (Gallus gallus)
    Aves CCR8-L1 C-C chemokine receptor 8 like 60.34(n)
    53.38(a)
      776400  NM_001080894.1  NP_001074363.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccr8.16
    BX537113.16
    (see all 6)
    Uncharacterized protein
    (see all 6)
    33(a)
    33(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    16(10749803-10752840)
    16(9973995-9980180)


    ENSEMBL Gene Tree for CCR8 (if available)
    TreeFam Gene Tree for CCR8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCR8 gene
    CCR62  CCR52  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/53 SIMAP similar genes for CCR8 using alignment to 3 protein entries:     CCR8_HUMAN (see all proteins) (see all similar genes):
    CCR2    CCR-5    CX3CR1    CCR1    CCR5    CCR4
    CCR3    BLR1    CXCR2    CXCR5    IL8RB    XCR1
    CCR6    BDKRB2    DKFZp686O088    CCR7    CCR9    SSTR1

    CCR8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/157 SNPs in CCR8 are shown (see all 157)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478350011,2
    --39369255(+) ATCTGA/GCTCAG 1 -- us2k10--------
    rs1891401701,2
    C--39369258(+) TGGCTC/TAGGAA 1 -- us2k10--------
    rs18750901,2
    C,F,H--39369259(-) TTTCCC/TGAGCC 1 -- us2k112Minor allele frequency- T:0.06NA WA CSA EA 377
    rs1413320421,2
    --39369587(+) TGAGGC/TGGTCC 1 -- us2k10--------
    rs121075271,2
    C,F,H--39369682(+) ACATAC/TAAAAC 1 -- us2k115Minor allele frequency- T:0.17NS EA NA WA 1892
    rs1144171601,2
    C,F--39369844(+) AACTGC/GTGGAC 1 -- us2k12Minor allele frequency- G:0.03NA EA 240
    rs1818400651,2
    --39369851(+) GGACTC/TAAGTG 1 -- us2k10--------
    rs98146191,2
    C,F--39369900(+) AGTGCA/CTGCCA 1 -- us2k14Minor allele frequency- C:0.28NA 126
    rs558361561,2
    C,F--39369912(+) CATGCC/TTGGCT 1 -- us2k14Minor allele frequency- T:0.21NA WA 242
    rs76472541,2
    C,F,H--39369947(+) gatgaT/Cgcatt 1 -- us2k115Minor allele frequency- C:0.08NS EA NA 1988

    HapMap Linkage Disequilibrium report for CCR8 (39371197 - 39375171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CCR8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv518801CNV Loss19592680
    nsv460509CNV Loss19166990
    esv29441CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601834    OMIM disorders: --

    20/25 diseases for CCR8 (see all 25):    About MalaCards
    molluscum contagiosum    kaposi's sarcoma    hiv type 1    hodgkin's lymphoma
    allergic rhinitis    non-hodgkin lymphoma    malt lymphoma    cutaneous t cell lymphoma
    rhinitis    chronic obstructive pulmonary disease    encephalomyelitis    meningitis
    adenoiditis    endometriosis    chronic lymphocytic leukemia    meningioma
    sarcoma    pneumonia    asthma    dementia

    2 diseases from the University of Copenhagen DISEASES database for CCR8:
    Asthma     Molluscum contagiosum

    CCR8 for disorders           About GeneDecksing

    10/19 Novoseek inferred disease relationships for CCR8 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    molluscum contagiosum 51 4 11493620 (2), 10620615 (1)
    immunodeficiency 43.7 5 10888633 (2), 9417093 (1), 16221874 (1), 9765485 (1)
    kaposi sarcoma 39.1 1 11133740 (1)
    airways disease 36.6 1 12901955 (1)
    inflammation 31.2 15 12009564 (2), 17014623 (1), 17641040 (1), 19208087 (1) (see all 9)
    asthma 29.2 8 16640325 (1), 18218997 (1), 18684970 (1), 18672380 (1) (see all 6)
    allergic rhinitis 26.1 1 16623955 (1)
    herpes 22.6 1 9834206 (1)
    hiv infections 22.3 3 16221874 (1), 12551893 (1)
    pulmonary disease chronic obstructive 17.3 1 11390417 (1)

    Genetic Association Database (GAD): CCR8
    Human Genome Epidemiology (HuGE) Navigator: CCR8 (6 documents)

    Export disorders for CCR8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCR8 gene, integrated from 9 sources (see all 184):
    (articles sorted by number of sources associating them with CCR8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. (PubMed id 8816377)1, 2, 3, 9 Napolitano M.... Santoni A. (1996)
    2. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. (PubMed id 8886020)1, 2, 3, 9 Zaballos A.... Marquez G. (1996)
    3. Identification of CCR8 as the specific receptor for the human beta- chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. (PubMed id 9469461)1, 2, 9 Goya I.... Marquez G. (1998)
    4. The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. (PubMed id 10540332)1, 2, 9 Garlisi C.G....Umland S.P. (1999)
    5. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. (PubMed id 9521068)1, 2, 9 Bernardini G....Napolitano M. (1998)
    6. Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. (PubMed id 12551893)1, 2, 9 DeVries M.E.... Kelvin D.J. (2003)
    7. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. (PubMed id 9207005)1, 2, 9 Tiffany H.L.... Murphy P.M. (1997)
    8. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    9. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    10. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1237 HGNC: 1609 AceView: CCR8 Ensembl:ENSG00000179934 euGenes: HUgn1237
    ECgene: CCR8 Kegg: 1237 H-InvDB: CCR8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCR8 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCR8 gene:
    Search GeneIP for patents involving CCR8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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