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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCR7 Gene

protein-coding   GIFtS: 63
GCID: GC17M038710

chemokine (C-C motif) receptor 7


(Previous symbols: CMKBR7, EBI1)
 Explore 92 diseases affiliated with
CCR7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCR7    

Aliases
for CCR7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-C Motif) Receptor 71 2     MIP-3 Beta Receptor2 3
CMKBR71 2 3 5     C-C Chemokine Receptor Type 72
EBI11 2 3 5     CC Chemokine Receptor 72
BLR21 2 3     Chemokine (C-C) Receptor 72
CDw1971 2 3     EBV-Induced G Protein-Coupled Receptor 12
CD1971 2     Epstein-Barr Virus Induced G-Protein Coupled Receptor2
Epstein-Barr Virus-Induced G-Protein Coupled Receptor 12 3     Epstein-Barr Virus Induced Gene 12
CC-CKR-72 3     Lymphocyte-Specific G Protein-Coupled Peptide Receptor2
CCR-72 3     EVI13
C-C CKR-72 3     CD197 Antigen3
EBV-Induced G-Protein Coupled Receptor 12 3     

External Ids:    HGNC: 16081   Entrez Gene: 12362   Ensembl: ENSG000001263537   OMIM: 6002425   UniProtKB: P322483   

Export aliases for CCR7 gene to outside databases

Previous GC identifers: GC17M038210 GC17M040885 GC17M038618 GC17M039083 GC17M035963 GC17M034504


Summaries
for CCR7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCR7:
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as
a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This
receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the
migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C
motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
Function: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal
lymphocyte functions

Gene Wiki entry for CCR7 (C-C chemokine receptor type 7)


Genomic Views
for CCR7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCR7 gene promoter:
         Bach2   STAT5A   GATA-1   c-Ets-1   Egr-4   MEF-2A   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCR7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCR7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q12-q21.2

CCR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038710:  view genomic region     (about GC identifiers)

Start:
 38,710,021 bp from pter      End:
 38,721,736 bp from pter
Size:
 11,716 bases      Orientation:
 minus strand

Proteins
for CCR7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248 (See protein sequence)
Recommended Name: C-C chemokine receptor type 7 precursor  
Size: 378 amino acids; 42874 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for CCR7: NX_P32248

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P32248

    • CCR7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001829.1  
    ENSEMBL proteins: 
     ENSP00000246657   ENSP00000462631   ENSP00000463075  
    Reactome Protein details: P32248
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    Uscn Proteins for CCR7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    CCR7 for ontologies           About GeneDecksing



    CCR7 Antibody Products: 
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    Uscn ELISAs and CLIAs for CCR7

    Protein Domains /
    Families
    for CCR7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCR7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001718 Chemokine_CCR7
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32248

    ProtoNet protein and cluster: P32248

    2 Blocks protein families:
    IPB000355 Chemokine receptor signature
    IPB001718 C-C chemokine receptor type 7 signature


    UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for CCR7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
    Function: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal
    lymphocyte functions
    Induction: By Epstein-Barr virus (EBV)

         Genatlas biochemistry entry for CCR7:
    chemokine CC,beta receptor 7,G protein coupled receptor,lymphocyte specific,homologous to mouse Ebi-1

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR7 (see all 21):
    hsa-miR-320a hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-4257 hsa-miR-30c-2*
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    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCR7

    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS16621978
    GO:0016493C-C chemokine receptor activity ISS--
    GO:0035757chemokine (C-C motif) ligand 19 binding IPI9507024
    GO:0035758chemokine (C-C motif) ligand 21 binding IPI9507024
    GO:0038117C-C motif chemokine 19 receptor activity IDA9507024


    CCR7 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Ccr7tm1Rfor for CCR7
         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ccr7):
     cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  nervous system  vision/eye 

    CCR7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCR7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    		Peptide ligand-binding receptors0.61
    2Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    3Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    		Peptide GPCRs0.46
    5Chemokine Signaling
    		Chemokine Signaling1.00
    		Chemokine signaling pathway0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CCR7
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    1 R&D Systems Pathway for CCR7
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR7 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 BioSystems Pathways for CCR7 
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/8        Reactome Pathways for CCR7 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    2         Kegg Pathways  (Kegg details for CCR7):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCR7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/183 Interacting proteins for CCR7 (P322483 ENSP000002466574) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL19Q997313, ENSP000003088154I2D: score=5 STRING: ENSP00000308815
    CCR10P460923, ENSP000003325044I2D: score=1 STRING: ENSP00000332504
    CCL21O005853, ENSP000002596074I2D: score=3 STRING: ENSP00000259607
    CCL22O006263, ENSP000002192354I2D: score=1 STRING: ENSP00000219235
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001768establishment of T cell polarity IC12729902
    GO:0001954positive regulation of cell-matrix adhesion IC15569314
    GO:0002407dendritic cell chemotaxis IC15778365
    GO:0002408myeloid dendritic cell chemotaxis IC14592837
    GO:0002606positive regulation of dendritic cell antigen processing and presentation ISS--


    CCR7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCR7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCR7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCR7
    10/24 Novoseek chemical compound relationships for CCR7 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mip-3beta 84.4 1 12437666 (1)
    ccl3 63.9 2 14735149 (1), 15784733 (1)
    larc 61.9 3 11180126 (1), 9365118 (1), 10934220 (1)
    rantes 61.5 10 19127964 (2), 14735149 (1), 11994442 (1), 18226915 (1) (see all 9)
    peg-10 51.7 3 16225771 (2), 17082584 (1)
    teck 51 1 10706668 (1)
    tarc 47.6 1 9365118 (1)
    ccl4 45 4 14735149 (1), 17133532 (1), 19127964 (1), 15611249 (1)
    pge2 43.9 20 19545899 (3), 17925490 (2), 12149218 (2), 19862774 (2) (see all 11)
    triptolide 30.7 7 17223196 (4), 15956285 (1)

    Search CenterWatch for drugs/clinical trials and news about CCR7 

    Transcripts
    for CCR7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCR7 gene: 
    NM_001838.3  

    Unigene Cluster for CCR7:

    Chemokine (C-C motif) receptor 7
    Hs.370036  [show with all ESTs]
    Unigene Representative Sequence: NM_001838
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246657(uc002huw.3) ENST00000579344 ENST00000578085

    miRNA
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    hsa-miR-320a hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-4257 hsa-miR-30c-2*
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK127810.1 AK310277.1 AK312732.1 AY587876.1 BC035343.1 L08176.1 L31581.1 

    2 DOTS entries:

    DT.206051  DT.92416274 

    24/91 AceView cDNA sequences (see all 91):

    AK127810 CA748681 AI682706 BQ710222 CD687913 BQ006256 CA448576 BU626418 
    CK904435 BI822179 BC035343 NM_001838 BP369453 AW574531 CD689024 BM023164 
    CR592465 CD246195 BX369492 CD696160 CD702670 AY587876 CD709166 BI910219 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCR7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:              -                           
    SP2:                                          
    SP3:              -     -                     


    ECgene alternative splicing isoforms for CCR7

    Expression
    for CCR7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCR7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTGCTTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCR7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PlacentaChorionic VillusHofbauer CellsExtraembryonic Tissues, Placenta
    OvaryAntral FollicleCumulus CellsOvary
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Mature dendritic-like cells (Derivation of dendri...)
    Syncytiotrophoblast-like cells (Generation of syncyt...)

    See CCR7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCR7

    SOURCE GeneReport for Unigene cluster: Hs.370036

    UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
    Tissue specificity: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in
    B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCR7: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for CCR7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCR7 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCR71 chemokine (C-C motif) receptor 7 69.79(n)
    68.1(a)    		   428315  NM_001198752.1  NP_001185681.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CCR76
    		 --
    		 62(a)
    		 1 ↔ 1
    		 6(70286891-70287958)
    zebrafish
    (Danio rerio)    		 Actinopterygii ccr71 chemokine (C-C motif) receptor 7 60.31(n)
    53.08(a)    		   565958  NM_001098743.1  NP_001092213.1 


    ENSEMBL Gene Tree for CCR7 (if available)
    TreeFam Gene Tree for CCR7 (if available) 

    Paralogs
    for CCR7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCR7 gene
    CCR62  CCR52  CXCR62  CXCR32  XCR12  CCR92  CCBP22  CCRL22  
    CX3CR12  CCR82  CXCR22  CCRL12  CCR42  CXCR12  CCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/45 SIMAP similar genes for CCR7 using alignment to 4 protein entries:     CCR7_HUMAN (see all proteins) (see all similar genes):
    CCR2    CXCR2    CCR-5    CCR9    CXCR6    CXCR1
    CCR5    CCR6    BLR1    CXCR5    IL8RB    CCR1
    CXCR4    CCR4    CCR3    CXCR3    AGTR1    F2RL1

    CCR7 for paralogs           About GeneDecksing



    Genomic Variants
    for CCR7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/217 NCBI SNPs in CCR7 are shown (see all 217)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1813855791,2
    		--38709701(+) AGTCCC/TCAGGT 1 -- int10--------
    rs1465560101,2
    		--38709719(+) TTACCC/TGGAAA 1 -- int10--------
    rs1400632991,2
    		--38709755(+) GGATCA/GGCATG 1 -- int10--------
    rs563202141,2
    		C,F,--38709835(+) NNNNTC/TCTGTC 1 -- int13Minor allele frequency- T:0.07NA 124
    rs1153084111,2
    		C,F,--38709846(+) CTCATC/TTTCCT 1 -- int11Minor allele frequency- T:0.07WA 118
    rs1498032851,2
    		--38710031(+) CATTTA/GCCAAA 1 -- ut310--------
    rs1999914371,2
    		--38710039(+) AAGAC-/TTTTTT 1 -- ut310--------
    rs1455443771,2
    		--38710041(+) AGACTG/TTTTTT 1 -- ut310--------
    rs1488775701,2
    		--38710075(+) TTTCCC/TCAAGG 1 -- ut310--------
    rs1842365301,2
    		--38710187(+) AGCTCG/TTGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCR7 (38710021 - 38721736 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCR7: --
    Human Gene Mutation Database (HGMD): CCR7

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR7
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR7

    Disorders / Diseases
    for CCR7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCR7 for disorders           About GeneDecksing

    OMIM gene information: 600242    OMIM disorders: --

    20/92 diseases for CCR7 (see all 92):    About MalaCards
    erdheim-chester disease    relapsing-remitting multiple sclerosis    langerhans-cell histiocytosis    human immunodeficiency virus infectious disease
    mycosis fungoides    common variable immunodeficiency    squamous cell carcinoma    anaplastic large cell lymphoma
    non-hodgkin lymphoma    idiopathic interstitial pneumonia    lupus erythematosus    b-cell lymphomas
    oral squamous cell carcinoma    multiple sclerosis    mantle cell lymphoma    squamous cell carcinoma of the head and neck
    esophageal squamous cell carcinoma    systemic lupus erythematosus    lymphocytic leukemia    myeloid leukemia

    2 diseases from the University of Copenhagen DISEASES database for CCR7:
    Melanoma     Leukemia

    10/59 Novoseek disease relationships for CCR7 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 44.5 136 15040017 (6), 19287948 (5), 12673677 (5), 17687340 (4) (see all 47)
    leukemia lymphocytic chronic 43 3 16225771 (1), 20145264 (1), 15155773 (1)
    inflammation 42 11 17337767 (1), 19208087 (1), 16116468 (1), 16118351 (1) (see all 10)
    b-all 41.7 5 16225771 (2), 17082584 (2), 16118018 (1)
    tumors 41 115 18696160 (6), 17337767 (4), 10786686 (4), 17966215 (4) (see all 47)
    skin metastases 31.7 2 11242036 (1), 16627550 (1)
    cancer 31.3 55 19287948 (4), 19363519 (3), 15755995 (2), 17032700 (2) (see all 18)
    hnscc 29.6 8 20036791 (4), 15608423 (2)
    necrosis 28.9 8 17063178 (1), 17182676 (1), 19300189 (1), 19424046 (1) (see all 8)
    autoimmune diseases 26.9 3 12799021 (1), 16887149 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCR7 (12 documents)

    Export disorders for CCR7 gene to outside databases

    Publications
    for CCR7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCR7 gene, integrated from 9 sources (see all 577):
    (articles sorted by number of sources associating them with CCR7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. (PubMed id 8383238)1, 2, 3 Birkenbach M.P....Kieff E. (1993)
    2. Cloning of human and mouse EBI1, a lymphoid-specific G-protein- coupled receptor encoded on human chromosome 17q12-q21.2. (PubMed id 7851893)1, 2, 9 Schweickart V.L.... Gray P.W. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Expression of CC-chemokine receptor 7 (CCR7) and CXC- chemokine receptor 4 (CXCR4) in head and neck squamous cell carcinoma. (PubMed id 20036791)1, 9 Ueda M....Kannagi R. (2010)
    5. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. (PubMed id 12673677)1, 9 Takanami I. (2003)
    6. Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. (PubMed id 18319253)1, 9 Pan M.R....Hung W.C. (2008)
    7. Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK. (PubMed id 15304089)1, 9 Boisleve F....Pallardy M. (2004)
    8. Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. (PubMed id 15753377)1, 9 Mori T....Hoon D.S. (2005)
    9. Oral and oropharyngeal squamous cell carcinomas expressing CCR7 have poor prognoses. (PubMed id 16223574)1, 9 Tsuzuki H....Fujieda S. (2006)
    10. Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1. (PubMed id 17178876)1, 9 Wilson J.L....Grimshaw M.J. (2006)

    External Searches for CCR7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CCR7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1236 HGNC: 1608 AceView: CCR7 Ensembl:ENSG00000126353 euGenes: HUgn1236
    ECgene: CCR7 Kegg: 1236 H-InvDB: CCR7

    Other Databases showing CCR7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCR7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCR7 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    Intellectual Property
    for CCR7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCR7 gene:
    Search GeneIP for patents involving CCR7

    GeneCards and IP:
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