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Aliases for CCR7 Gene

Aliases for CCR7 Gene

  • C-C Motif Chemokine Receptor 7 2 3 5
  • Epstein-Barr Virus-Induced G-Protein Coupled Receptor 1 3 4
  • Chemokine (C-C Motif) Receptor 7 2 3
  • MIP-3 Beta Receptor 3 4
  • CC-CKR-7 3 4
  • CMKBR7 3 4
  • CDw197 3 4
  • CCR-7 3 4
  • EBI1 3 4
  • BLR2 3 4
  • Lymphocyte-Specific G Protein-Coupled Peptide Receptor 3
  • EBV-Induced G Protein-Coupled Receptor 1 3
  • EBV-Induced G-Protein Coupled Receptor 1 4
  • Epstein-Barr Virus Induced Gene 1 3
  • C-C Chemokine Receptor Type 7 3
  • Bukitts Lymphoma Receptor 2 3
  • CC Chemokine Receptor 7 3
  • CD197 Antigen 4
  • C-C CKR-7 4
  • CD197 3
  • EVI1 4

External Ids for CCR7 Gene

Previous HGNC Symbols for CCR7 Gene

  • CMKBR7
  • EBI1

Previous GeneCards Identifiers for CCR7 Gene

  • GC17M038210
  • GC17M040885
  • GC17M038618
  • GC17M039083
  • GC17M035963
  • GC17M038710
  • GC17M034504

Summaries for CCR7 Gene

Entrez Gene Summary for CCR7 Gene

  • The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCR7 Gene

CCR7 (C-C Motif Chemokine Receptor 7) is a Protein Coding gene. Diseases associated with CCR7 include Pars Planitis and Chronic Actinic Dermatitis. Among its related pathways are Peptide ligand-binding receptors and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. GO annotations related to this gene include G-protein coupled receptor activity and chemokine (C-C motif) ligand 19 binding. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CCR7 Gene

  • Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Gene Wiki entry for CCR7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR7 Gene

Genomics for CCR7 Gene

Regulatory Elements for CCR7 Gene

Enhancers for CCR7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G040546 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +8.4 8381 20.3 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 CCR7 THRA TOP2A KRT222 IGFBP4 ENSG00000266088 KRTAP3-2 KRT34 GJD3 CASC3
GH17G040595 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18 -32.4 -32443 4.3 CREB3L1 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC SMARCE1 CCR7 SNORD124 KRT222 KRT28 RARA WIPF2 KRTAP3-2 CASC3 KRTAP2-1
GH17G040601 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.8 -40.2 -40154 8.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A GLI4 YBX1 ZNF2 YY1 ZNF121 SMARCE1 CCR7 KRT222 RAPGEFL1 RARA CASC3 KRTAP3-2 WIPF2 ENSG00000279775 GC17M040594
GH17G040528 2.1 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +28.9 28878 15.8 CREB3L1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 MCM3 TBX21 MEF2D CCR7 RARA TOP2A IGFBP4 RPL23AP75 CDC6 SNORD124 SMARCE1 GRB7 CASC3
GH17G040515 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +45.4 45414 9.6 CREB3L1 MLX DMAP1 FEZF1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 SNORD124 TOP2A CDC6 CCR7 IGFBP4 RPL23AP75 GJD3 RARA MSL1 SMARCE1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCR7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCR7 Gene

Chromosome:
17
Start:
40,553,769 bp from pter
End:
40,565,484 bp from pter
Size:
11,716 bases
Orientation:
Minus strand

Genomic View for CCR7 Gene

Genes around CCR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR7 Gene

Proteins for CCR7 Gene

  • Protein details for CCR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32248-CCR7_HUMAN
    Recommended name:
    C-C chemokine receptor type 7
    Protein Accession:
    P32248

    Protein attributes for CCR7 Gene

    Size:
    378 amino acids
    Molecular mass:
    42874 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR7 Gene

Post-translational modifications for CCR7 Gene

  • Glycosylation at Asn36
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR7 Gene

No data available for DME Specific Peptides for CCR7 Gene

Domains & Families for CCR7 Gene

Gene Families for CCR7 Gene

Suggested Antigen Peptide Sequences for CCR7 Gene

Graphical View of Domain Structure for InterPro Entry

P32248

UniProtKB/Swiss-Prot:

CCR7_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR7: view

Function for CCR7 Gene

Molecular function for CCR7 Gene

GENATLAS Biochemistry:
chemokine CC,beta receptor 7,G protein coupled receptor,lymphocyte specific,homologous to mouse Ebi-1
UniProtKB/Swiss-Prot Function:
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV).

Gene Ontology (GO) - Molecular Function for CCR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,IEA 16621978
GO:0004950 chemokine receptor activity IEA --
GO:0016493 C-C chemokine receptor activity ISS,IEA --
GO:0035757 chemokine (C-C motif) ligand 19 binding IPI 9507024
genes like me logo Genes that share ontologies with CCR7: view
genes like me logo Genes that share phenotypes with CCR7: view

Animal Models for CCR7 Gene

MGI Knock Outs for CCR7:

Animal Model Products

miRNA for CCR7 Gene

miRTarBase miRNAs that target CCR7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCR7 Gene

Localization for CCR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR7 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 21051556
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 18308860
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCR7: view

Pathways & Interactions for CCR7 Gene

genes like me logo Genes that share pathways with CCR7: view

SIGNOR curated interactions for CCR7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CCR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001768 establishment of T cell polarity IC 12729902
GO:0001954 positive regulation of cell-matrix adhesion IC 15569314
GO:0002407 dendritic cell chemotaxis IC 15778365
GO:0002408 myeloid dendritic cell chemotaxis IDA 11602640
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS --
genes like me logo Genes that share ontologies with CCR7: view

Drugs & Compounds for CCR7 Gene

(15) Drugs for CCR7 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL19 Pharma Agonist 0
CCL21 Pharma Agonist 0
[<SUP>125</SUP>I]CCL19 (HUMAN) Pharma 0
[<SUP>125</SUP>I]CCL21 (HUMAN) Pharma 0

(15) Additional Compounds for CCR7 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL19
Full agonist, Agonist
[<sup>125</sup>I]CCL21
Full agonist, Agonist
genes like me logo Genes that share compounds with CCR7: view

Transcripts for CCR7 Gene

Unigene Clusters for CCR7 Gene

Chemokine (C-C motif) receptor 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -

Relevant External Links for CCR7 Gene

GeneLoc Exon Structure for
CCR7
ECgene alternative splicing isoforms for
CCR7

Expression for CCR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR7 Gene

This gene is overexpressed in Whole Blood (x12.1) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for CCR7 Gene

This gene is overexpressed in CD4 Tcells (40.9), Blymphocyte (20.3), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR7 Gene



Protein tissue co-expression partners for CCR7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCR7 Gene:

CCR7

SOURCE GeneReport for Unigene cluster for CCR7 Gene:

Hs.370036

mRNA Expression by UniProt/SwissProt for CCR7 Gene:

P32248-CCR7_HUMAN
Tissue specificity: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Evidence on tissue expression from TISSUES for CCR7 Gene

  • Blood(4.3)
  • Nervous system(4.3)
  • Lymph node(3.9)
  • Spleen(3.6)
  • Intestine(2.7)
  • Bone marrow(2.5)
  • Lung(2.4)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with CCR7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR7 Gene

Orthologs for CCR7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR7 34 35
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia CCR7 34 35
  • 90.83 (n)
dog
(Canis familiaris)
Mammalia CCR7 34 35
  • 90.04 (n)
mouse
(Mus musculus)
Mammalia Ccr7 34 16 35
  • 85.8 (n)
rat
(Rattus norvegicus)
Mammalia Ccr7 34
  • 85.54 (n)
oppossum
(Monodelphis domestica)
Mammalia CCR7 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCR7 34 35
  • 69.88 (n)
lizard
(Anolis carolinensis)
Reptilia CCR7 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccr7 34
  • 64.8 (n)
zebrafish
(Danio rerio)
Actinopterygii ccr7 34 35
  • 60.31 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11674 34
Species where no ortholog for CCR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR7 Gene

ENSEMBL:
Gene Tree for CCR7 (if available)
TreeFam:
Gene Tree for CCR7 (if available)

Paralogs for CCR7 Gene

Variants for CCR7 Gene

Sequence variations from dbSNP and Humsavar for CCR7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000011225 -- 40,554,261(+) ATGTC(C/T)GCTTT utr-variant-3-prime
rs1000072817 -- 40,562,148(+) TCCAG(C/T)AACCA intron-variant, upstream-variant-2KB
rs1000125082 -- 40,562,480(+) CATCC(C/T)GGCCC intron-variant, upstream-variant-2KB
rs1000218234 -- 40,561,393(+) GTCAG(C/T)GGCCT intron-variant, upstream-variant-2KB
rs1000249262 -- 40,561,782(+) CACAA(A/C)TTTTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCR7 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv473329 CNV novel sequence insertion 20440878
nsv473368 CNV novel sequence insertion 20440878
nsv574994 CNV gain 21841781

Variation tolerance for CCR7 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR7 Gene

Human Gene Mutation Database (HGMD)
CCR7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR7 Gene

Disorders for CCR7 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CCR7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pars planitis
  • posterior cyclitis
chronic actinic dermatitis
  • actinic reticuloid
thymic hyperplasia
  • hyperplasia of thymus gland
lymphadenitis
  • acute adenitis
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search CCR7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR7

Genetic Association Database (GAD)
CCR7
Human Genome Epidemiology (HuGE) Navigator
CCR7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR7
genes like me logo Genes that share disorders with CCR7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR7 Gene

Publications for CCR7 Gene

  1. Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis. (PMID: 17587445) Kahlmann D. … FAPrster R. (BMC Genet. 2007) 3 22 46 64
  2. Cloning of human and mouse EBI1, a lymphoid-specific G-protein- coupled receptor encoded on human chromosome 17q12-q21.2. (PMID: 7851893) Schweickart V.L. … Gray P.W. (Genomics 1994) 3 4 22 64
  3. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. (PMID: 8383238) Birkenbach M.P. … Kieff E. (J. Virol. 1993) 2 3 4 64
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64

Products for CCR7 Gene

  • Addgene plasmids for CCR7

Sources for CCR7 Gene

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