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Aliases for CCR7 Gene

Aliases for CCR7 Gene

  • C-C Motif Chemokine Receptor 7 2 3
  • Chemokine (C-C Motif) Receptor 7 2 3 5
  • Epstein-Barr Virus-Induced G-Protein Coupled Receptor 1 3 4
  • MIP-3 Beta Receptor 3 4
  • CC-CKR-7 3 4
  • CMKBR7 3 4
  • CDw197 3 4
  • CCR-7 3 4
  • EBI1 3 4
  • BLR2 3 4
  • Lymphocyte-Specific G Protein-Coupled Peptide Receptor 3
  • EBV-Induced G Protein-Coupled Receptor 1 3
  • EBV-Induced G-Protein Coupled Receptor 1 4
  • Epstein-Barr Virus Induced Gene 1 3
  • Bukitts Lymphoma Receptor 2 3
  • CC Chemokine Receptor 7 3
  • CD197 Antigen 4
  • C-C CKR-7 4
  • CD197 3
  • EVI1 4

External Ids for CCR7 Gene

Previous HGNC Symbols for CCR7 Gene

  • CMKBR7
  • EBI1

Previous GeneCards Identifiers for CCR7 Gene

  • GC17M038210
  • GC17M040885
  • GC17M038618
  • GC17M039083
  • GC17M035963
  • GC17M038710
  • GC17M034504

Summaries for CCR7 Gene

Entrez Gene Summary for CCR7 Gene

  • The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCR7 Gene

CCR7 (C-C Motif Chemokine Receptor 7) is a Protein Coding gene. Diseases associated with CCR7 include Chronic Actinic Dermatitis and Idiopathic Interstitial Pneumonia. Among its related pathways are Peptide ligand-binding receptors and Th17 Differentiation Pathway. GO annotations related to this gene include G-protein coupled receptor activity and chemokine (C-C motif) ligand 19 binding. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CCR7 Gene

  • Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Gene Wiki entry for CCR7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR7 Gene

Genomics for CCR7 Gene

Regulatory Elements for CCR7 Gene

Enhancers for CCR7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCR7 on UCSC Golden Path with GeneCards custom track

Promoters for CCR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCR7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCR7 Gene

Chromosome:
17
Start:
40,553,769 bp from pter
End:
40,565,484 bp from pter
Size:
11,716 bases
Orientation:
Minus strand

Genomic View for CCR7 Gene

Genes around CCR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR7 Gene

Proteins for CCR7 Gene

  • Protein details for CCR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32248-CCR7_HUMAN
    Recommended name:
    C-C chemokine receptor type 7
    Protein Accession:
    P32248

    Protein attributes for CCR7 Gene

    Size:
    378 amino acids
    Molecular mass:
    42874 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR7 Gene

Proteomics data for CCR7 Gene at MOPED

Post-translational modifications for CCR7 Gene

  • Glycosylation at Asn 36
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR7 Gene

Antibody Products

No data available for DME Specific Peptides for CCR7 Gene

Domains & Families for CCR7 Gene

Gene Families for CCR7 Gene

Suggested Antigen Peptide Sequences for CCR7 Gene

Graphical View of Domain Structure for InterPro Entry

P32248

UniProtKB/Swiss-Prot:

CCR7_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR7: view

Function for CCR7 Gene

Molecular function for CCR7 Gene

GENATLAS Biochemistry:
chemokine CC,beta receptor 7,G protein coupled receptor,lymphocyte specific,homologous to mouse Ebi-1
UniProtKB/Swiss-Prot Function:
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
UniProtKB/Swiss-Prot Induction:
By Epstein-Barr virus (EBV).

Gene Ontology (GO) - Molecular Function for CCR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038117 C-C motif chemokine 19 receptor activity IDA 9507024
genes like me logo Genes that share ontologies with CCR7: view
genes like me logo Genes that share phenotypes with CCR7: view

Animal Models for CCR7 Gene

MGI Knock Outs for CCR7:

Animal Model Products

miRNA for CCR7 Gene

miRTarBase miRNAs that target CCR7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCR7 Gene

Localization for CCR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR7 Gene COMPARTMENTS Subcellular localization image for CCR7 gene
Compartment Confidence
cytosol 5
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CCR7: view

Pathways & Interactions for CCR7 Gene

genes like me logo Genes that share pathways with CCR7: view

SIGNOR curated interactions for CCR7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CCR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001768 establishment of T cell polarity IC 12729902
GO:0001954 positive regulation of cell-matrix adhesion IC 15569314
GO:0002408 myeloid dendritic cell chemotaxis IDA 11602640
GO:0002606 positive regulation of dendritic cell antigen processing and presentation IEA,ISS --
GO:0002922 positive regulation of humoral immune response IEA,ISS --
genes like me logo Genes that share ontologies with CCR7: view

Drugs & Compounds for CCR7 Gene

(15) Drugs for CCR7 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL19 Pharma Agonist 0
CCL21 Pharma Agonist 0
[<SUP>125</SUP>I]CCL19 (HUMAN) Pharma 0
[<SUP>125</SUP>I]CCL21 (HUMAN) Pharma 0

(15) Additional Compounds for CCR7 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL19
Full agonist, Agonist
[<sup>125</sup>I]CCL21
Full agonist, Agonist
genes like me logo Genes that share compounds with CCR7: view

Transcripts for CCR7 Gene

Unigene Clusters for CCR7 Gene

Chemokine (C-C motif) receptor 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: - -

Relevant External Links for CCR7 Gene

GeneLoc Exon Structure for
CCR7
ECgene alternative splicing isoforms for
CCR7

Expression for CCR7 Gene

mRNA expression in normal human tissues for CCR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR7 Gene

This gene is overexpressed in Whole Blood (x12.1) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for CCR7 Gene

This gene is overexpressed in CD4 Tcells (40.9), Blymphocyte (20.3), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR7 Gene



SOURCE GeneReport for Unigene cluster for CCR7 Gene Hs.370036

mRNA Expression by UniProt/SwissProt for CCR7 Gene

P32248-CCR7_HUMAN
Tissue specificity: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
genes like me logo Genes that share expression patterns with CCR7: view

Protein tissue co-expression partners for CCR7 Gene

- Elite partner

Primer Products

Orthologs for CCR7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCR7 35
  • 90.83 (n)
  • 92.33 (a)
CCR7 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR7 35
  • 90.04 (n)
  • 91.27 (a)
CCR7 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr7 35
  • 85.8 (n)
  • 87.04 (a)
Ccr7 16
Ccr7 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCR7 35
  • 99.56 (n)
  • 99.74 (a)
CCR7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr7 35
  • 85.54 (n)
  • 86.24 (a)
oppossum
(Monodelphis domestica)
Mammalia CCR7 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCR7 35
  • 69.88 (n)
  • 68.1 (a)
CCR7 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCR7 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccr7 35
  • 64.8 (n)
  • 60.77 (a)
zebrafish
(Danio rerio)
Actinopterygii ccr7 35
  • 60.31 (n)
  • 53.08 (a)
ccr7 36
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11674 35
Species with no ortholog for CCR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR7 Gene

ENSEMBL:
Gene Tree for CCR7 (if available)
TreeFam:
Gene Tree for CCR7 (if available)

Paralogs for CCR7 Gene

genes like me logo Genes that share paralogs with CCR7: view

Variants for CCR7 Gene

Sequence variations from dbSNP and Humsavar for CCR7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_049383 -
rs588019 -- 40,558,855(+) GTGTG(A/G)AGAAG intron-variant
rs1018953 -- 40,562,943(+) CCTCT(A/T)TTACC intron-variant, upstream-variant-2KB
rs1666262 -- 40,565,471(+) CCTGT(C/T)TGGGG utr-variant-5-prime
rs2228015 -- 40,558,934(-) AACCA(A/G)TGAAA intron-variant, reference, missense

Variation tolerance for CCR7 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR7 Gene

Human Gene Mutation Database (HGMD)
CCR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCR7 Gene

Disorders for CCR7 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CCR7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic actinic dermatitis
  • actinic reticuloid
idiopathic interstitial pneumonia
  • idiopathic pulmonary fibrosis
langerhans-cell histiocytosis
  • histiocytosis x
polymyositis
  • pm
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search CCR7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR7

Genetic Association Database (GAD)
CCR7
Human Genome Epidemiology (HuGE) Navigator
CCR7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR7
genes like me logo Genes that share disorders with CCR7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR7 Gene

Publications for CCR7 Gene

  1. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. (PMID: 8383238) Birkenbach M.P. … Kieff E. (J. Virol. 1993) 2 3 4 67
  2. Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck. (PMID: 19615795) Liu F.Y. … Sun C.F. (Br J Oral Maxillofac Surg 2010) 3 23
  3. Expression of CC-chemokine receptor 7 (CCR7) and CXC-chemokine receptor 4 (CXCR4) in head and neck squamous cell carcinoma. (PMID: 20036791) Ueda M. … Kannagi R. (Auris Nasus Larynx 2010) 3 23
  4. High CCR7 mRNA expression of cancer cells is associated with lymph node involvement in patients with esophageal squamous cell carcinoma. (PMID: 19287948) Ishida K. … Yamaue H. (Int. J. Oncol. 2009) 3 23
  5. CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. (PMID: 19513547) Arigami T. … Aikou T. (Int. J. Oncol. 2009) 3 23

Products for CCR7 Gene

Sources for CCR7 Gene

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