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CCR7 Gene

protein-coding   GIFtS: 67
GCID: GC17M038710

Chemokine (C-C Motif) Receptor 7


(Previous symbols: CMKBR7, EBI1)
  See CCR7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Receptor 71 2     CD1972
CMKBR71 2 3 5     C-C Chemokine Receptor Type 72
EBI11 2 3 5     CC Chemokine Receptor 72
Epstein-Barr Virus-Induced G-Protein Coupled Receptor 12 3     Chemokine (C-C) Receptor 72
BLR22 3     EBV-Induced G Protein-Coupled Receptor 12
CC-CKR-72 3     Epstein-Barr Virus Induced G-Protein Coupled Receptor2
CCR-72 3     Epstein-Barr Virus Induced Gene 12
CDw1972 3     Lymphocyte-Specific G Protein-Coupled Peptide Receptor2
C-C CKR-72 3     EVI13
EBV-Induced G-Protein Coupled Receptor 12 3     CD197 Antigen3
MIP-3 Beta Receptor2 3     

External Ids:    HGNC: 16081   Entrez Gene: 12362   Ensembl: ENSG000001263537   OMIM: 6002425   UniProtKB: P322483   

Export aliases for CCR7 gene to outside databases

Previous GC identifers: GC17M038210 GC17M040885 GC17M038618 GC17M039083 GC17M035963 GC17M034504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCR7 Gene:
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was
identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B
lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has
been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell
maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this
receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCR7 Gene:
CCR7 (chemokine (C-C motif) receptor 7) is a protein-coding gene. Diseases associated with CCR7 include chronic actinic dermatitis, and erdheim-chester disease. GO annotations related to this gene include chemokine (C-C motif) ligand 19 binding and G-protein coupled receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
Function: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal
lymphocyte functions

Gene Wiki entry for CCR7 (C-C chemokine receptor type 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCR7 gene promoter:
         Bach2   STAT5A   GATA-1   c-Ets-1   Egr-4   MEF-2A   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR7 promoter sequence
   Search Chromatin IP Primers for CCR7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q12-q21.2

CCR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038710:  view genomic region     (about GC identifiers)

Start:
38,710,021 bp from pter      End:
38,721,736 bp from pter
Size:
11,716 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248 (See protein sequence)
Recommended Name: C-C chemokine receptor type 7 precursor  
Size: 378 amino acids; 42874 Da

Explore the universe of human proteins at neXtProt for CCR7: NX_P32248

Explore proteomics data for CCR7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn36
  • Modification sites at PhosphoSitePlus

  • See CCR7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001829.1  
    ENSEMBL proteins: 
     ENSP00000246657   ENSP00000462631   ENSP00000463075  
    Reactome Protein details: P32248

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR7
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001718 Chemokine_CCR7
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32248

    ProtoNet protein and cluster: P32248

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB001718 C-C chemokine receptor type 7 signature


    UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CCR7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR7_HUMAN, P32248
    Function: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal
    lymphocyte functions
    Induction: By Epstein-Barr virus (EBV)

         Genatlas biochemistry entry for CCR7:
    chemokine CC,beta receptor 7,G protein coupled receptor,lymphocyte specific,homologous to mouse Ebi-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS16621978
    GO:0005515protein binding ----
    GO:0016493C-C chemokine receptor activity ISS--
    GO:0035757chemokine (C-C motif) ligand 19 binding IPI9507024
    GO:0035758chemokine (C-C motif) ligand 21 binding IPI9507024
         
    Find genes that share ontologies with CCR7           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccr7):
     cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  nervous system  vision/eye 

    Find genes that share phenotypes with CCR7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccr7tm1Rfor for CCR7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR7

    miRNA
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    miRTarBase miRNAs that target CCR7:
    hsa-mir-335-5p (MIRT018216)

    Block miRNA regulation of human, mouse, rat CCR7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCR7 (see all 21):
    hsa-miR-320a hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-4257 hsa-miR-30c-2*
    SwitchGear 3'UTR luciferase reporter plasmidCCR7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCR7

    Gene Editing
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12542) for CCR7 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCR7_HUMAN, P32248: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2
    cytoskeleton1
    lysosome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CCR7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCR7 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    5Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33


    Find genes that share SuperPaths with CCR7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CCR7
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR7 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 BioSystems Pathways for CCR7
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for CCR7
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for CCR7):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR7: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCR7 (P322482, 3 ENSP000002466574) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL19Q997313, ENSP000003088154I2D: score=5 STRING: ENSP00000308815
    CCR10P460923, ENSP000003325044I2D: score=1 STRING: ENSP00000332504
    CCL21O005853, ENSP000002596074I2D: score=3 STRING: ENSP00000259607
    CCL22O006263, ENSP000002192354I2D: score=1 STRING: ENSP00000219235
    CD247P209632MINT-8409798
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001768establishment of T cell polarity IC12729902
    GO:0001954positive regulation of cell-matrix adhesion IC15569314
    GO:0002407dendritic cell chemotaxis IC15778365
    GO:0002408myeloid dendritic cell chemotaxis IC14592837
    GO:0002606positive regulation of dendritic cell antigen processing and presentation ISS--

    Find genes that share ontologies with CCR7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCR7

    4 IUPHAR Ligands for CCR7 (CCR7)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCL21
    AgonistFull agonist9.39507024
    CCL19
    AgonistFull agonist7.7 - 99153236 9507024
    [125I]CCL19
    AgonistFull agonist7.7 - 9--
    [125I]CCL21
    AgonistFull agonist7.7 - 9--

    Selected Novoseek inferred chemical compound relationships for CCR7 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mip-3beta 84.4 1 12437666 (1)
    ccl3 63.9 2 14735149 (1), 15784733 (1)
    larc 61.9 3 11180126 (1), 9365118 (1), 10934220 (1)
    rantes 61.5 10 19127964 (2), 14735149 (1), 11994442 (1), 18226915 (1) (see all 9)
    peg-10 51.7 3 16225771 (2), 17082584 (1)
    teck 51 1 10706668 (1)
    tarc 47.6 1 9365118 (1)
    ccl4 45 4 14735149 (1), 17133532 (1), 19127964 (1), 15611249 (1)
    pge2 43.9 20 19545899 (3), 17925490 (2), 12149218 (2), 19862774 (2) (see all 11)
    triptolide 30.7 7 17223196 (4), 15956285 (1)



    Find genes that share compounds with CCR7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCR7 gene: 
    NM_001838.3  

    Unigene Cluster for CCR7:

    Chemokine (C-C motif) receptor 7
    Hs.370036  [show with all ESTs]
    Unigene Representative Sequence: NM_001838
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246657(uc002huw.3) ENST00000579344 ENST00000578085
    miRNA
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    hsa-miR-320a hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-4257 hsa-miR-30c-2*
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    Additional mRNA sequence: 

    AK127810.1 AK310277.1 AK312732.1 AY587876.1 BC035343.1 L08176.1 L31581.1 

    2 DOTS entries:

    DT.206051  DT.92416274 

    Selected AceView cDNA sequences (see all 91):

    CD689024 CR592465 BQ006256 CA448576 CK904435 AI682706 BM023164 BC035343 
    AK127810 BU626418 NM_001838 BP369453 BI822179 AW574531 CD246195 CD687913 
    CA748681 BQ710222 CD709166 AY587876 CD709389 CK904434 BX369492 CD705318 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCR7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:              -                           
    SP2:                                          
    SP3:              -     -                     


    ECgene alternative splicing isoforms for CCR7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCR7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGCTTTC
    CCR7 Expression
    About this image


    CCR7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 7 entries
             T-Cytotoxic Cells Peripheral Blood
             Mature dendritic-like cells
     
     Thymus (Hematopoietic System)    fully expand to see all 4 entries
             T Helper Cells Thymus
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Hofbauer Cells Chorionic Villus
             Syncytiotrophoblast-like cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    CCR7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCR7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370036

    UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
    Tissue specificity: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly
    up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR7: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CCR7 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr71 , 5 chemokine (C-C motif) receptor 71, 5 85.8(n)1
    87.04(a)1
      11 (62.92 cM)5
    127751  NM_007719.21  NP_031745.21 
     991441965 
    chicken
    (Gallus gallus)
    Aves CCR71 chemokine (C-C motif) receptor 7 69.88(n)
    68.1(a)
      428315  NM_001198752.1  NP_001185681.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCR76
    chemokine (C-C motif) receptor 7
    60(a)
    1 ↔ 1
    6(70284520-70301000)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ccr71 chemokine (C-C motif) receptor 7 64.8(n)
    60.77(a)
      100485139  XM_004918693.1  XP_004918750.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccr71 chemokine (C-C motif) receptor 7 60.31(n)
    53.08(a)
      565958  NM_001098743.1  NP_001092213.1 


    ENSEMBL Gene Tree for CCR7 (if available)
    TreeFam Gene Tree for CCR7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCR7 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CCR7 using alignment to 4 protein entries:     CCR7_HUMAN (see all proteins) (see all similar genes):
    CXCR2    CCR2    CCR-5    CCR9    CXCR6    CXCR1
    CCR5    CCR6    BLR1    CXCR5    IL8RB    CCR1
    CXCR4    CCR4    CCR3    CXCR3    ACKR4    AGTR1

    Find genes that share paralogs with CCR7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCR7 (see all 286)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813855791,2
    --38709701(+) AGTCCC/TCAGGT 1 -- int10--------
    rs1465560101,2
    --38709719(+) TTACCC/TGGAAA 1 -- int10--------
    rs1400632991,2
    --38709755(+) GGATCA/GGCATG 1 -- int10--------
    rs563202141,2
    C,F--38709835(+) GACCTC/TCTGTC 1 -- int13Minor allele frequency- T:0.07NA 124
    rs1153084111,2
    C,F--38709846(+) CTCATC/TTTCCT 1 -- int11Minor allele frequency- T:0.07WA 118
    rs1498032851,2
    --38710031(+) CATTTA/GCCAAA 1 -- ut310--------
    rs1999914371,2
    --38710039(+) AAGAC-/TTTTTT 1 -- ut310--------
    rs1455443771,2
    --38710041(+) AGACTG/TTTTTT 1 -- ut310--------
    rs1488775701,2
    C--38710075(+) TTTCCC/TCAAGG 1 -- ut310--------
    rs1842365301,2
    C--38710187(+) AGCTCA/G/TTGGGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CCR7 (38710021 - 38721736 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCR7: --
    Human Gene Mutation Database (HGMD): CCR7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCR7
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600242    OMIM disorders: --

    8 diseases for CCR7:    
    About MalaCards
    chronic actinic dermatitis    erdheim-chester disease    idiopathic interstitial pneumonia    squamous cell carcinoma of the head and neck
    mycosis fungoides    polymyositis    tetanus    dermatomyositis

    1 disease from the University of Copenhagen DISEASES database for CCR7:
    Melanoma

    Find genes that share disorders with CCR7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCR7 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 44.5 136 15040017 (6), 19287948 (5), 12673677 (5), 17687340 (4) (see all 47)
    leukemia lymphocytic chronic 43 3 16225771 (1), 20145264 (1), 15155773 (1)
    inflammation 42 11 17337767 (1), 19208087 (1), 16116468 (1), 16118351 (1) (see all 10)
    b-all 41.7 5 16225771 (2), 17082584 (2), 16118018 (1)
    tumors 41 115 18696160 (6), 17337767 (4), 10786686 (4), 17966215 (4) (see all 47)
    skin metastases 31.7 2 11242036 (1), 16627550 (1)
    cancer 31.3 55 19287948 (4), 19363519 (3), 15755995 (2), 17032700 (2) (see all 18)
    hnscc 29.6 8 20036791 (4), 15608423 (2)
    necrosis 28.9 8 17063178 (1), 17182676 (1), 19300189 (1), 19424046 (1) (see all 8)
    autoimmune diseases 26.9 3 12799021 (1), 16887149 (1)

    Genetic Association Database (GAD): CCR7
    Human Genome Epidemiology (HuGE) Navigator: CCR7 (12 documents)

    Export disorders for CCR7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCR7 gene, integrated from 10 sources (see all 595):
    (articles sorted by number of sources associating them with CCR7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. (PubMed id 8383238)1, 2, 3 Birkenbach M.P....Kieff E. (J. Virol. 1993)
    2. Cloning of human and mouse EBI1, a lymphoid-specific G-protein- coupled receptor encoded on human chromosome 17q12-q21.2. (PubMed id 7851893)1, 2, 9 Schweickart V.L.... Gray P.W. (Genomics 1994)
    3. Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis. (PubMed id 17587445)1, 4, 9 Kahlmann D....FAPrster R. (BMC Genet. 2007)
    4. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4, 9 Enjuanes A....Campo E. (Cancer Res. 2008)
    5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    6. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    8. Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan. (PubMed id 19196101)1, 4 Lin G.T....Chang H.W. (OMICS 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Expression of CC-chemokine receptor 7 (CCR7) and CXC-chemokine receptor 4 (CXCR4) in head and neck squamous cell carcinoma. (PubMed id 20036791)1, 9 Ueda M....Kannagi R. (Auris Nasus Larynx 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1236 HGNC: 1608 AceView: CCR7 Ensembl:ENSG00000126353 euGenes: HUgn1236
    ECgene: CCR7 Kegg: 1236 H-InvDB: CCR7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCR7 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCR7 gene:
    Search GeneIP for patents involving CCR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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