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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCR7 Gene

protein-coding   GIFtS: 66
GCID: GC17M038710

Chemokine (C-C Motif) Receptor 7


(Previous symbols: CMKBR7, EBI1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Receptor 71 2     CD1972
CMKBR71 2 3 5     C-C Chemokine Receptor Type 72
EBI11 2 3 5     CC Chemokine Receptor 72
Epstein-Barr Virus-Induced G-Protein Coupled Receptor 12 3     Chemokine (C-C) Receptor 72
BLR22 3     EBV-Induced G Protein-Coupled Receptor 12
CC-CKR-72 3     Epstein-Barr Virus Induced G-Protein Coupled Receptor2
CCR-72 3     Epstein-Barr Virus Induced Gene 12
CDw1972 3     Lymphocyte-Specific G Protein-Coupled Peptide Receptor2
C-C CKR-72 3     EVI13
EBV-Induced G-Protein Coupled Receptor 12 3     CD197 Antigen3
MIP-3 Beta Receptor2 3     

External Ids:    HGNC: 16081   Entrez Gene: 12362   Ensembl: ENSG000001263537   OMIM: 6002425   UniProtKB: P322483   

Export aliases for CCR7 gene to outside databases

Previous GC identifers: GC17M038210 GC17M040885 GC17M038618 GC17M039083 GC17M035963 GC17M034504


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCR7 Gene:
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was
identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B
lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has
been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell
maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this
receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCR7 Gene: 
CCR7 (chemokine (C-C motif) receptor 7) is a protein-coding gene. Diseases associated with CCR7 include erdheim-chester disease, and idiopathic interstitial pneumonia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Peptide GPCRs. GO annotations related to this gene include chemokine (C-C motif) ligand 19 binding and G-protein coupled receptor activity. An important paralog of this gene is CCR6.

UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
Function: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal
lymphocyte functions

Gene Wiki entry for CCR7 (C-C chemokine receptor type 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCR7 gene promoter:
         Bach2   STAT5A   GATA-1   c-Ets-1   Egr-4   MEF-2A   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCR7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q12-q21.2

CCR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038710:  view genomic region     (about GC identifiers)

Start:
38,710,021 bp from pter      End:
38,721,736 bp from pter
Size:
11,716 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248 (See protein sequence)
Recommended Name: C-C chemokine receptor type 7 precursor  
Size: 378 amino acids; 42874 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for CCR7: NX_P32248

Explore proteomics data for CCR7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32248

  • CCR7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCR7 Protein Expression
    REFSEQ proteins: NP_001829.1  
    ENSEMBL proteins: 
     ENSP00000246657   ENSP00000462631   ENSP00000463075  
    Reactome Protein details: P32248
    Human Recombinant Protein Products for CCR7: 
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    Cloud-Clone Corp. Proteins for CCR7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    CCR7 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for CCR7 
    Cloud-Clone Corp. CLIAs for CCR7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR7 
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001718 Chemokine_CCR7
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32248

    ProtoNet protein and cluster: P32248

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB001718 C-C chemokine receptor type 7 signature


    UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CCR7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR7_HUMAN, P32248
    Function: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal
    lymphocyte functions
    Induction: By Epstein-Barr virus (EBV)

         Genatlas biochemistry entry for CCR7:
    chemokine CC,beta receptor 7,G protein coupled receptor,lymphocyte specific,homologous to mouse Ebi-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS16621978
    GO:0016493C-C chemokine receptor activity ISS--
    GO:0035757chemokine (C-C motif) ligand 19 binding IPI9507024
    GO:0035758chemokine (C-C motif) ligand 21 binding IPI9507024
    GO:0038117C-C motif chemokine 19 receptor activity IDA9507024
         
    CCR7 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccr7):
     cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  nervous system  vision/eye 

    CCR7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccr7tm1Rfor for CCR7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCR7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCR7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR7 

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    SwitchGear 3'UTR luciferase reporter plasmidCCR7 3' UTR sequence
    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCR7 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    3PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    4Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCR7
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    1 R&D Systems Pathway for CCR7
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR7 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 BioSystems Pathways for CCR7
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    5/8        Reactome Pathways for CCR7 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    3         Kegg Pathways  (Kegg details for CCR7):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Transcriptional misregulation in cancer


    CCR7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/185 Interacting proteins for CCR7 (P322482, 3 ENSP000002466574) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL19Q997313, ENSP000003088154I2D: score=5 STRING: ENSP00000308815
    CCR10P460923, ENSP000003325044I2D: score=1 STRING: ENSP00000332504
    CCL21O005853, ENSP000002596074I2D: score=3 STRING: ENSP00000259607
    CCL22O006263, ENSP000002192354I2D: score=1 STRING: ENSP00000219235
    CD247P209632MINT-8409798
    About this table

    Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001768establishment of T cell polarity IC12729902
    GO:0001954positive regulation of cell-matrix adhesion IC15569314
    GO:0002407dendritic cell chemotaxis IC15778365
    GO:0002408myeloid dendritic cell chemotaxis IC14592837
    GO:0002606positive regulation of dendritic cell antigen processing and presentation ISS--

    CCR7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCR7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCR7

    4 IUPHAR Ligands for CCR7 (CCR7)    About this table 
    LigandTypeActionAffinityPubmed IDs
    CCL21
    AgonistFull agonist9.39507024
    CCL19
    AgonistFull agonist7.7 - 99153236 9507024
    [125I]CCL19
    AgonistFull agonist7.7 - 9--
    [125I]CCL21
    AgonistFull agonist7.7 - 9--

    10/24 Novoseek inferred chemical compound relationships for CCR7 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mip-3beta 84.4 1 12437666 (1)
    ccl3 63.9 2 14735149 (1), 15784733 (1)
    larc 61.9 3 11180126 (1), 9365118 (1), 10934220 (1)
    rantes 61.5 10 19127964 (2), 14735149 (1), 11994442 (1), 18226915 (1) (see all 9)
    peg-10 51.7 3 16225771 (2), 17082584 (1)
    teck 51 1 10706668 (1)
    tarc 47.6 1 9365118 (1)
    ccl4 45 4 14735149 (1), 17133532 (1), 19127964 (1), 15611249 (1)
    pge2 43.9 20 19545899 (3), 17925490 (2), 12149218 (2), 19862774 (2) (see all 11)
    triptolide 30.7 7 17223196 (4), 15956285 (1)

    Search CenterWatch for drugs/clinical trials and news about CCR7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCR7 gene: 
    NM_001838.3  

    Unigene Cluster for CCR7:

    Chemokine (C-C motif) receptor 7
    Hs.370036  [show with all ESTs]
    Unigene Representative Sequence: NM_001838
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246657(uc002huw.3) ENST00000579344 ENST00000578085
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR7 (see all 21):
    hsa-miR-320a hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-4257 hsa-miR-30c-2*
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    Additional mRNA sequence: 

    AK127810.1 AK310277.1 AK312732.1 AY587876.1 BC035343.1 L08176.1 L31581.1 

    2 DOTS entries:

    DT.206051  DT.92416274 

    24/91 AceView cDNA sequences (see all 91):

    NM_001838 CD687913 BI822179 BQ006256 CA448576 BM023164 AW574531 CA748681 
    CD246195 BC035343 CK904435 CR592465 BP369453 AI682706 CD689024 AK127810 
    BU626418 BQ710222 CD696160 BX369492 BI839037 CK904434 BI910219 L31581 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCR7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
    SP1:              -                           
    SP2:                                          
    SP3:              -     -                     


    ECgene alternative splicing isoforms for CCR7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCR7 expression in normal human tissues (normalized intensities)      CCR7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGCTTTC
    CCR7 Expression
    About this image


    CCR7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 9 entries
             T Helper Cells Thymus
             Mature dendritic-like cells ( Derivation of dendritic cells )
             Peripheral blood Pan-T Cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 5 entries
             T Helper Cells Thymus
             Thymus   
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Hofbauer Cells Chorionic Villus
             placenta ; trophoblastic cells   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             breast ; myoepithelial cells   

    See CCR7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCR7

    SOURCE GeneReport for Unigene cluster: Hs.370036

    UniProtKB/Swiss-Prot: CCR7_HUMAN, P32248
    Tissue specificity: Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly
    up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCR7: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCR7 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr71 , 5 chemokine (C-C motif) receptor 71, 5 85.8(n)1
    87.04(a)1
      11 (62.92 cM)5
    127751  NM_007719.21  NP_031745.21 
     991441965 
    chicken
    (Gallus gallus)
    Aves CCR71 chemokine (C-C motif) receptor 7 69.79(n)
    68.1(a)
      428315  NM_001198752.1  NP_001185681.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCR76
    Uncharacterized protein
    60(a)
    1 ↔ 1
    6(70284520-70301000)
    zebrafish
    (Danio rerio)
    Actinopterygii ccr71 chemokine (C-C motif) receptor 7 60.31(n)
    53.08(a)
      565958  NM_001098743.1  NP_001092213.1 


    ENSEMBL Gene Tree for CCR7 (if available)
    TreeFam Gene Tree for CCR7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCR7 gene
    CCR62  CCR52  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/47 SIMAP similar genes for CCR7 using alignment to 4 protein entries:     CCR7_HUMAN (see all proteins) (see all similar genes):
    CXCR2    CCR2    CCR-5    CCR9    CXCR6    CXCR1
    CCR5    CCR6    BLR1    CXCR5    IL8RB    CCR1
    CXCR4    CCR4    CCR3    CXCR3    AGTR1    F2RL1

    CCR7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 SNPs in CCR7 are shown (see all 286)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0493834
    ----see VAR_0493832 M V mis40--------
    rs1813855791,2
    --38709701(+) AGTCCC/TCAGGT 1 -- int10--------
    rs1465560101,2
    --38709719(+) TTACCC/TGGAAA 1 -- int10--------
    rs1400632991,2
    --38709755(+) GGATCA/GGCATG 1 -- int10--------
    rs563202141,2
    C,F--38709835(+) GACCTC/TCTGTC 1 -- int13Minor allele frequency- T:0.07NA 124
    rs1153084111,2
    C,F--38709846(+) CTCATC/TTTCCT 1 -- int11Minor allele frequency- T:0.07WA 118
    rs1498032851,2
    --38710031(+) CATTTA/GCCAAA 1 -- ut310--------
    rs1999914371,2
    --38710039(+) AAGAC-/TTTTTT 1 -- ut310--------
    rs1455443771,2
    --38710041(+) AGACTG/TTTTTT 1 -- ut310--------
    rs1488775701,2
    C--38710075(+) TTTCCC/TCAAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCR7 (38710021 - 38721736 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCR7: --

    Human Gene Mutation Database (HGMD): CCR7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCR7
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600242    OMIM disorders: --

    20/84 diseases for CCR7 (see all 84):    About MalaCards
    erdheim-chester disease    idiopathic interstitial pneumonia    squamous cell carcinoma of the head and neck    polymyositis
    relapsing-remitting multiple sclerosis    mycosis fungoides    dermatomyositis    tetanus
    human immunodeficiency virus infectious disease    langerhans-cell histiocytosis    b-cell chronic lymphocytic leukemia    mediastinitis
    histiocytosis    nasopharyngitis    common variable immunodeficiency    pneumonia
    chronic lymphocytic leukemia    chagas disease    cytomegalovirus infection    hepatitis b virus infection

    1 disease from the University of Copenhagen DISEASES database for CCR7:
    Melanoma

    CCR7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/59 Novoseek inferred disease relationships for CCR7 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 44.5 136 15040017 (6), 19287948 (5), 12673677 (5), 17687340 (4) (see all 47)
    leukemia lymphocytic chronic 43 3 16225771 (1), 20145264 (1), 15155773 (1)
    inflammation 42 11 17337767 (1), 19208087 (1), 16116468 (1), 16118351 (1) (see all 10)
    b-all 41.7 5 16225771 (2), 17082584 (2), 16118018 (1)
    tumors 41 115 18696160 (6), 17337767 (4), 10786686 (4), 17966215 (4) (see all 47)
    skin metastases 31.7 2 11242036 (1), 16627550 (1)
    cancer 31.3 55 19287948 (4), 19363519 (3), 15755995 (2), 17032700 (2) (see all 18)
    hnscc 29.6 8 20036791 (4), 15608423 (2)
    necrosis 28.9 8 17063178 (1), 17182676 (1), 19300189 (1), 19424046 (1) (see all 8)
    autoimmune diseases 26.9 3 12799021 (1), 16887149 (1)

    Genetic Association Database (GAD): CCR7
    Human Genome Epidemiology (HuGE) Navigator: CCR7 (12 documents)

    Export disorders for CCR7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCR7 gene, integrated from 9 sources (see all 587):
    (articles sorted by number of sources associating them with CCR7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. (PubMed id 8383238)1, 2, 3 Birkenbach M.P....Kieff E. (1993)
    2. Cloning of human and mouse EBI1, a lymphoid-specific G-protein- coupled receptor encoded on human chromosome 17q12-q21.2. (PubMed id 7851893)1, 2, 9 Schweickart V.L.... Gray P.W. (1994)
    3. Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis. (PubMed id 17587445)1, 4, 9 Kahlmann D....Forster R. (2007)
    4. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4, 9 Enjuanes A....Campo E. (2008)
    5. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    6. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    7. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    8. Combinational Polymorphisms of Seven CXCL12-Related Genes Are Protective against Breast Cancer in Taiwan. (PubMed id 19196101)1, 4 Lin G.T....Chang H.W. (2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Expression of CC-chemokine receptor 7 (CCR7) and CXC- chemokine receptor 4 (CXCR4) in head and neck squamous cell carcinoma. (PubMed id 20036791)1, 9 Ueda M....Kannagi R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1236 HGNC: 1608 AceView: CCR7 Ensembl:ENSG00000126353 euGenes: HUgn1236
    ECgene: CCR7 Kegg: 1236 H-InvDB: CCR7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCR7 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCR7 gene:
    Search GeneIP for patents involving CCR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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