Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCR6 Gene

Aliases for CCR6 Gene

  • C-C Motif Chemokine Receptor 6 2 3
  • Chemokine (C-C Motif) Receptor 6 2 3 5
  • G-Protein Coupled Receptor 29 3 4
  • Chemokine Receptor-Like 3 3 4
  • LARC Receptor 3 4
  • C-C CKR-6 3 4
  • CC-CKR-6 3 4
  • STRL22 3 4
  • CKR-L3 3 4
  • CMKBR6 3 4
  • GPRCY4 3 4
  • CCR-6 3 4
  • CKRL3 3 4
  • GPR29 3 4
  • DRY6 3 4
  • Seven-Transmembrane Receptor, Lymphocyte, 22 3
  • G Protein-Coupled Receptor 29 3
  • Chemokine (C-C) Receptor 6 3
  • CD196 Antigen 4
  • GPR-CY4 4
  • CD196 3
  • BN-1 3
  • DCR2 3

External Ids for CCR6 Gene

Previous HGNC Symbols for CCR6 Gene

  • STRL22

Previous GeneCards Identifiers for CCR6 Gene

  • GC06P166889
  • GC06P167409
  • GC06P167445
  • GC06P167383
  • GC06P164997
  • GC06P167525

Summaries for CCR6 Gene

Entrez Gene Summary for CCR6 Gene

  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR6 Gene

CCR6 (C-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CCR6 include limited scleroderma and diffuse cutaneous systemic sclerosis. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CCR6 Gene

  • Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

Gene Wiki entry for CCR6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR6 Gene

Genomics for CCR6 Gene

Regulatory Elements for CCR6 Gene

Genomic Location for CCR6 Gene

Chromosome:
6
Start:
167,111,807 bp from pter
End:
167,139,696 bp from pter
Size:
27,890 bases
Orientation:
Plus strand

Genomic View for CCR6 Gene

Genes around CCR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR6 Gene

Proteins for CCR6 Gene

  • Protein details for CCR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51684-CCR6_HUMAN
    Recommended name:
    C-C chemokine receptor type 6
    Protein Accession:
    P51684
    Secondary Accessions:
    • E1P5C6
    • P78553
    • Q92846

    Protein attributes for CCR6 Gene

    Size:
    374 amino acids
    Molecular mass:
    42494 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB02144.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CCR6 Gene

Proteomics data for CCR6 Gene at MOPED

Post-translational modifications for CCR6 Gene

  • Glycosylation at Asn 7 and Asn 23
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR6 Gene

Antibody Products

No data available for DME Specific Peptides for CCR6 Gene

Domains & Families for CCR6 Gene

Gene Families for CCR6 Gene

Suggested Antigen Peptide Sequences for CCR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51684

UniProtKB/Swiss-Prot:

CCR6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR6: view

Function for CCR6 Gene

Molecular function for CCR6 Gene

GENATLAS Biochemistry:
chemokine CC beta receptor,expressed in lymphocyte and monocyte,highly homolog to EBI1,IL8RA,IL8RB,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.
UniProtKB/Swiss-Prot Induction:
By IL2/interleukin-2.

Gene Ontology (GO) - Molecular Function for CCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9186513
genes like me logo Genes that share ontologies with CCR6: view
genes like me logo Genes that share phenotypes with CCR6: view

Human Phenotype Ontology for CCR6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CCR6 Gene

MGI Knock Outs for CCR6:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCR6 Gene

Localization for CCR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR6 Gene COMPARTMENTS Subcellular localization image for CCR6 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with CCR6: view

Pathways & Interactions for CCR6 Gene

genes like me logo Genes that share pathways with CCR6: view

Gene Ontology (GO) - Biological Process for CCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9186513
GO:0007165 signal transduction TAS 9186513
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0010634 positive regulation of epithelial cell migration IEA --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with CCR6: view

No data available for SIGNOR curated interactions for CCR6 Gene

Drugs & Compounds for CCR6 Gene

(6) Drugs for CCR6 Gene - From: DGIdb, IUPHAR, Novoseek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
beta-defensin 4A Pharma Full agonist, Agonist 0
CCL20 Pharma Full agonist, Agonist 0
CCL20-SEAP(His)<sub>6</sub> Pharma Full agonist, Agonist 0
calcium Nutra 0
[<SUP>125</SUP>I]CCL20 (HUMAN) Pharma 0

(7) Additional Compounds for CCR6 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL20
Full agonist, Agonist
genes like me logo Genes that share compounds with CCR6: view

Transcripts for CCR6 Gene

Unigene Clusters for CCR6 Gene

Chemokine (C-C motif) receptor 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR6 Gene

No ASD Table

Relevant External Links for CCR6 Gene

GeneLoc Exon Structure for
CCR6
ECgene alternative splicing isoforms for
CCR6

Expression for CCR6 Gene

mRNA expression in normal human tissues for CCR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR6 Gene

This gene is overexpressed in Spleen (x9.7) and Small Intestine - Terminal Ileum (x4.6).

Protein differential expression in normal tissues from HIPED for CCR6 Gene

This gene is overexpressed in Lymph node (38.2), CD4 Tcells (19.2), and Blymphocyte (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR6 Gene



SOURCE GeneReport for Unigene cluster for CCR6 Gene Hs.46468

mRNA Expression by UniProt/SwissProt for CCR6 Gene

P51684-CCR6_HUMAN
Tissue specificity: Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
genes like me logo Genes that share expression patterns with CCR6: view

Protein tissue co-expression partners for CCR6 Gene

Primer Products

In Situ Assay Products

Orthologs for CCR6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR6 36
  • 99 (a)
OneToOne
CCR6 35
  • 99.29 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia CCR6 36
  • 79 (a)
OneToOne
CCR6 35
  • 77.06 (n)
  • 79.4 (a)
dog
(Canis familiaris)
Mammalia CCR6 35
  • 76.65 (n)
  • 79.14 (a)
CCR6 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr6 16
Ccr6 36
  • 75 (a)
OneToOne
Ccr6 35
  • 75.3 (n)
  • 75.2 (a)
oppossum
(Monodelphis domestica)
Mammalia CCR6 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr6 35
  • 76.07 (n)
  • 76.44 (a)
chicken
(Gallus gallus)
Aves CCR6 35
  • 63.38 (n)
  • 60.28 (a)
CCR6 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCR6 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccr6 35
  • 57.2 (n)
  • 50.7 (a)
zebrafish
(Danio rerio)
Actinopterygii ccr6b 36
  • 42 (a)
OneToMany
ccr6a 36
  • 43 (a)
OneToMany
ccr6a 35
  • 56.1 (n)
  • 48 (a)
rice
(Oryza sativa)
Liliopsida Os.15285 35
Species with no ortholog for CCR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR6 Gene

ENSEMBL:
Gene Tree for CCR6 (if available)
TreeFam:
Gene Tree for CCR6 (if available)

Paralogs for CCR6 Gene

genes like me logo Genes that share paralogs with CCR6: view

Variants for CCR6 Gene

Sequence variations from dbSNP and Humsavar for CCR6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1012657 -- 167,111,654(-) TTTCT(G/T)TGTTT upstream-variant-2KB
rs1556413 -- 167,111,255(-) AACCT(C/T)GTAAT upstream-variant-2KB
rs2023305 -- 167,111,410(-) ATAAA(A/G)GAGAA upstream-variant-2KB
rs2345784 -- 167,125,365(+) GATGA(A/T)CAATG intron-variant
rs3073674 -- 167,124,817(+) ACACA(-/CA/CACA)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCR6 Gene

Variant ID Type Subtype PubMed ID
esv2752099 CNV Gain 17911159
nsv469673 CNV Loss 16826518
essv22845 CNV CNV 17122850
dgv2033e1 CNV Complex 17122850
esv21674 CNV Loss 19812545
nsv7998 CNV Loss 18304495
esv2664671 CNV Deletion 23128226
esv2733220 CNV Deletion 23290073

Variation tolerance for CCR6 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR6 Gene

HapMap Linkage Disequilibrium report
CCR6
Human Gene Mutation Database (HGMD)
CCR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR6 Gene

Disorders for CCR6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CCR6 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
limited scleroderma
  • limited cutaneous systemic sclerosis
diffuse cutaneous systemic sclerosis
  • dcssc
pustulosis palmaris et plantaris
  • palmoplantar pustulosis
clostridium difficile colitis
  • pseudomembranous colitis
stromal keratitis
- elite association - COSMIC cancer census association via MalaCards
Search CCR6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR6

Genetic Association Database (GAD)
CCR6
Human Genome Epidemiology (HuGE) Navigator
CCR6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR6
genes like me logo Genes that share disorders with CCR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR6 Gene

Publications for CCR6 Gene

  1. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. (PMID: 8886020) Zaballos A. … Marquez G. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23 67
  2. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. (PMID: 20453841) Kochi Y. … Yamamoto K. (Nat. Genet. 2010) 3 23
  3. Isoleucine/leucine2 is essential for chemoattractant activity of beta-defensin Defb14 through chemokine receptor 6. (PMID: 20022113) Tyrrell C. … Dorin J.R. (Mol. Immunol. 2010) 3 23
  4. CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function. (PMID: 20194631) Rivino L. … Geginat J. (J. Exp. Med. 2010) 3 23
  5. Expression of chemokine receptor CCR6 as a molecular determinant of adrenal metastatic relapse in patients with primary lung cancer. (PMID: 20439195) Raynaud C.M. … Soria J.C. (Clin Lung Cancer 2010) 3 23

Products for CCR6 Gene

Sources for CCR6 Gene

Back to Top

Content