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Aliases for CCR6 Gene

Aliases for CCR6 Gene

  • C-C Motif Chemokine Receptor 6 2 3 5
  • Chemokine (C-C Motif) Receptor 6 2 3
  • Chemokine Receptor-Like 3 3 4
  • LARC Receptor 3 4
  • C-C CKR-6 3 4
  • CC-CKR-6 3 4
  • STRL22 3 4
  • CKR-L3 3 4
  • CMKBR6 3 4
  • GPRCY4 3 4
  • CCR-6 3 4
  • CKRL3 3 4
  • GPR29 3 4
  • DRY6 3 4
  • Seven-Transmembrane Receptor, Lymphocyte, 22 3
  • C-C Chemokine Receptor Type 6 3
  • G Protein-Coupled Receptor 29 3
  • G-Protein Coupled Receptor 29 4
  • Chemokine (C-C) Receptor 6 3
  • CD196 Antigen 4
  • GPR-CY4 4
  • CD196 3
  • BN-1 3
  • DCR2 3

External Ids for CCR6 Gene

Previous HGNC Symbols for CCR6 Gene

  • STRL22

Previous GeneCards Identifiers for CCR6 Gene

  • GC06P166889
  • GC06P167409
  • GC06P167445
  • GC06P167383
  • GC06P164997
  • GC06P167525

Summaries for CCR6 Gene

Entrez Gene Summary for CCR6 Gene

  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR6 Gene

CCR6 (C-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CCR6 include Limited Scleroderma and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR6 Gene

  • Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).

Gene Wiki entry for CCR6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR6 Gene

Genomics for CCR6 Gene

Regulatory Elements for CCR6 Gene

Enhancers for CCR6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F167111 1.6 FANTOM5 Ensembl ENCODE 53.1 +2.4 2413 5.9 HDGF ELF3 TBP PKNOX1 ATF1 TBL1XR1 BMI1 THRB RAD21 ZNF143 CCR6 RNASET2 LOC105378122
GH06F167117 1.3 FANTOM5 ENCODE 45.1 +9.3 9280 6.3 HDGF PKNOX1 MLX WRNIP1 ARID4B DMAP1 YY1 SLC30A9 CBX5 ZNF143 CCR6 RNASET2 ENSG00000249141 LOC105378122
GH06F167150 1.6 FANTOM5 Ensembl ENCODE 11.5 +40.7 40733 3.4 ELF3 TBP PKNOX1 TBL1XR1 SIN3A RAD21 EGR1 ELK1 CBX5 ETV6 GPR31 RNASET2 CCR6 FGFR1OP LOC105378120 ENSG00000249141 UNC93A RPS6KA2 RPS6KA2-AS1 AFDN
GH06F167046 1.4 FANTOM5 Ensembl ENCODE 12.6 -64.3 -64339 2.3 HDGF CTCF PKNOX1 RAD21 POLR2A ZNF366 EED ETV6 CREM STAT1 RNASET2 CCR6 FGFR1OP LOC105378120 ENSG00000249141 GPR31 GC06P167051 PIR56971 GC06P167042
GH06F167089 1.7 FANTOM5 Ensembl ENCODE 10.2 -18.8 -18837 7.3 HDGF PKNOX1 MLX WRNIP1 DMAP1 ZNF48 ZNF143 MXD4 ZHX2 JUNB RNASET2 FGFR1OP LOC105378120 CCR6 GPR31 PIR47545 PIR53334
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCR6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCR6 Gene

Chromosome:
6
Start:
167,111,807 bp from pter
End:
167,139,696 bp from pter
Size:
27,890 bases
Orientation:
Plus strand

Genomic View for CCR6 Gene

Genes around CCR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR6 Gene

Proteins for CCR6 Gene

  • Protein details for CCR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51684-CCR6_HUMAN
    Recommended name:
    C-C chemokine receptor type 6
    Protein Accession:
    P51684
    Secondary Accessions:
    • E1P5C6
    • P78553
    • Q92846

    Protein attributes for CCR6 Gene

    Size:
    374 amino acids
    Molecular mass:
    42494 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB02144.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CCR6 Gene

Post-translational modifications for CCR6 Gene

  • Glycosylation at Asn 7 and Asn 23
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR6 Gene

No data available for DME Specific Peptides for CCR6 Gene

Domains & Families for CCR6 Gene

Gene Families for CCR6 Gene

Suggested Antigen Peptide Sequences for CCR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51684

UniProtKB/Swiss-Prot:

CCR6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR6: view

Function for CCR6 Gene

Molecular function for CCR6 Gene

GENATLAS Biochemistry:
chemokine CC beta receptor,expressed in lymphocyte and monocyte,highly homolog to EBI1,IL8RA,IL8RB,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).
UniProtKB/Swiss-Prot Induction:
By IL2/interleukin-2.

Gene Ontology (GO) - Molecular Function for CCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004872 receptor activity TAS 9186513
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 11001880
GO:0005515 protein binding IPI 20068036
genes like me logo Genes that share ontologies with CCR6: view
genes like me logo Genes that share phenotypes with CCR6: view

Human Phenotype Ontology for CCR6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CCR6 Gene

MGI Knock Outs for CCR6:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCR6 Gene

Localization for CCR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR6 Gene

Cell membrane; Multi-pass membrane protein. Cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR6 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9186513
GO:0009986 cell surface IEA,IDA 12081481
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCR6: view

Pathways & Interactions for CCR6 Gene

genes like me logo Genes that share pathways with CCR6: view

Gene Ontology (GO) - Biological Process for CCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0002523 leukocyte migration involved in inflammatory response ISS --
GO:0006928 movement of cell or subcellular component TAS 9186513
GO:0006935 chemotaxis IMP 12081481
GO:0006955 immune response TAS 9223454
genes like me logo Genes that share ontologies with CCR6: view

No data available for SIGNOR curated interactions for CCR6 Gene

Drugs & Compounds for CCR6 Gene

(6) Drugs for CCR6 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
beta-defensin 4A Pharma Full agonist, Agonist 0
CCL20 Pharma Full agonist, Agonist 0
CCL20-SEAP(His)<sub>6</sub> Pharma Full agonist, Agonist 0
calcium Nutra 0
[<SUP>125</SUP>I]CCL20 (HUMAN) Pharma 0

(7) Additional Compounds for CCR6 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL20
Full agonist, Agonist
genes like me logo Genes that share compounds with CCR6: view

Transcripts for CCR6 Gene

mRNA/cDNA for CCR6 Gene

Unigene Clusters for CCR6 Gene

Chemokine (C-C motif) receptor 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR6 Gene

No ASD Table

Relevant External Links for CCR6 Gene

GeneLoc Exon Structure for
CCR6
ECgene alternative splicing isoforms for
CCR6

Expression for CCR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR6 Gene

This gene is overexpressed in Spleen (x9.7) and Small Intestine - Terminal Ileum (x4.6).

Protein differential expression in normal tissues from HIPED for CCR6 Gene

This gene is overexpressed in Lymph node (38.2), CD4 Tcells (19.2), and Blymphocyte (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR6 Gene



Protein tissue co-expression partners for CCR6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCR6 Gene:

CCR6

SOURCE GeneReport for Unigene cluster for CCR6 Gene:

Hs.46468

mRNA Expression by UniProt/SwissProt for CCR6 Gene:

P51684-CCR6_HUMAN
Tissue specificity: Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
genes like me logo Genes that share expression patterns with CCR6: view

Orthologs for CCR6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR6 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia CCR6 34 35
  • 77.06 (n)
dog
(Canis familiaris)
Mammalia CCR6 34 35
  • 76.65 (n)
rat
(Rattus norvegicus)
Mammalia Ccr6 34
  • 76.07 (n)
mouse
(Mus musculus)
Mammalia Ccr6 34 16 35
  • 75.3 (n)
oppossum
(Monodelphis domestica)
Mammalia CCR6 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCR6 34 35
  • 63.38 (n)
lizard
(Anolis carolinensis)
Reptilia CCR6 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccr6 34
  • 57.2 (n)
zebrafish
(Danio rerio)
Actinopterygii ccr6a 34 35
  • 56.1 (n)
ccr6b 35
  • 42 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.15285 34
Species where no ortholog for CCR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR6 Gene

ENSEMBL:
Gene Tree for CCR6 (if available)
TreeFam:
Gene Tree for CCR6 (if available)

Paralogs for CCR6 Gene

genes like me logo Genes that share paralogs with CCR6: view

Variants for CCR6 Gene

Sequence variations from dbSNP and Humsavar for CCR6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1012656 -- 167,111,815(-) TTCAC(C/G)CATAC downstream-variant-500B, utr-variant-5-prime
rs1012657 -- 167,111,654(-) TTTCT(G/T)TGTTT downstream-variant-500B, upstream-variant-2KB
rs1015077 -- 167,113,018(+) TGTAT(A/G)ACAAT intron-variant, nc-transcript-variant
rs10214916 -- 167,129,596(+) TTTTT(G/T)AAATG intron-variant, upstream-variant-2KB
rs10683579 -- 167,124,265(+) AACTG(-/GA/GAA)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCR6 Gene

Variant ID Type Subtype PubMed ID
nsv7998 CNV loss 18304495
nsv469673 CNV loss 16826518
nsv1024657 CNV loss 25217958
esv3611648 CNV loss 21293372
esv2759492 CNV gain 17122850
esv2752099 CNV gain 17911159
esv2733220 CNV deletion 23290073
esv2664671 CNV deletion 23128226
esv21674 CNV loss 19812545

Variation tolerance for CCR6 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR6 Gene

Human Gene Mutation Database (HGMD)
CCR6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR6 Gene

Disorders for CCR6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CCR6 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
limited scleroderma
  • crest syndrome
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
clostridium difficile colitis
  • pseudomembranous colitis
pustulosis palmaris et plantaris
  • palmoplantar pustulosis
stromal keratitis
- elite association - COSMIC cancer census association via MalaCards
Search CCR6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR6

Genetic Association Database (GAD)
CCR6
Human Genome Epidemiology (HuGE) Navigator
CCR6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR6
genes like me logo Genes that share disorders with CCR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR6 Gene

Publications for CCR6 Gene

  1. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. (PMID: 8886020) Zaballos A. … Marquez G. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 22 64
  2. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. (PMID: 20453841) Kochi Y. … Yamamoto K. (Nat. Genet. 2010) 3 22 46 64
  3. Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC. (PMID: 9169459) Baba M. … Yoshie O. (J. Biol. Chem. 1997) 3 4 22 64
  4. A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. (PMID: 23765988) Caballero-Campo P. … Gerton G.L. (J. Cell. Physiol. 2014) 3 4 64
  5. Deficient human I^-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. (PMID: 25122636) Diao R. … Chan H.C. (Sci Transl Med 2014) 3 4 64

Products for CCR6 Gene

Sources for CCR6 Gene

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