Aliases for CCR6 Gene
External Ids for CCR6 Gene
Previous HGNC Symbols for CCR6 Gene
Previous GeneCards Identifiers for CCR6 Gene
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCR6 Gene
CCR6 (Chemokine (C-C Motif) Receptor 6) is a Protein Coding gene. Diseases associated with CCR6 include limited scleroderma and diffuse cutaneous systemic sclerosis. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR7.
UniProtKB/Swiss-Prot for CCR6 Gene
Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.