Aliases for CCR6 Gene
External Ids for CCR6 Gene
Previous HGNC Symbols for CCR6 Gene
Previous GeneCards Identifiers for CCR6 Gene
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCR6 Gene
CCR6 (Chemokine (C-C Motif) Receptor 6) is a Protein Coding gene. Diseases associated with CCR6 include erdheim-chester disease and diffuse scleroderma. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.
UniProtKB/Swiss-Prot for CCR6 Gene
Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.