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CCR6 Gene

protein-coding   GIFtS: 67
GCID: GC06P167525

Chemokine (C-C Motif) Receptor 6


(Previous symbol: STRL22)
  See CCR6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Receptor 61 2     G-Protein Coupled Receptor 292 3
STRL221 2 3     LARC Receptor2 3
CKRL32 3 5     BN-12
CMKBR62 3 5     CD1962
GPR292 3 5     DCR22
GPRCY42 3 5     C-C Chemokine Receptor Type 62
Chemokine Receptor-Like 32 3     Chemokine (C-C) Receptor 62
CC-CKR-62 3     G Protein-Coupled Receptor 292
CCR-62 3     Seven-Transmembrane Receptor, Lymphocyte, 222
CKR-L32 3     GPR-CY43
DRY62 3     CD196 Antigen3
C-C CKR-62 3     

External Ids:    HGNC: 16071   Entrez Gene: 12352   Ensembl: ENSG000001124867   OMIM: 6018355   UniProtKB: P516843   

Export aliases for CCR6 gene to outside databases

Previous GC identifers: GC06P166889 GC06P167409 GC06P167445 GC06P167383 GC06P164997


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCR6 Gene:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane
protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells
and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This
receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and
it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological
responses. Alternatively spliced transcript variants that encode the same protein have been described for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCR6 Gene:
CCR6 (chemokine (C-C motif) receptor 6) is a protein-coding gene. Diseases associated with CCR6 include erdheim-chester disease, and granulomatosis with polyangiitis. GO annotations related to this gene include C-C chemokine receptor activity and receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCR6_HUMAN, P51684
Function: Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by
increasing the intracellular calcium ions level

Gene Wiki entry for CCR6 (C-C chemokine receptor type 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCR6 gene promoter:
         GR   AML1a   Pbx1a   GR-beta   FOXO4   GR-alpha   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR6 promoter sequence
   Search Chromatin IP Primers for CCR6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

CCR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P167525:  view genomic region     (about GC identifiers)

Start:
167,525,295 bp from pter      End:
167,553,184 bp from pter
Size:
27,890 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCR6_HUMAN, P51684 (See protein sequence)
Recommended Name: C-C chemokine receptor type 6  
Size: 374 amino acids; 42494 Da
Caution: It is uncertain whether Met-1 or Met-6 is the initiator
Sequence caution: Sequence=CAB02144.1; Type=Erroneous initiation;
Secondary accessions: E1P5C6 P78553 Q92846

Explore the universe of human proteins at neXtProt for CCR6: NX_P51684

Explore proteomics data for CCR6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7, Asn23
  • Modification sites at PhosphoSitePlus

  • See CCR6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004358.2  NP_113597.2  

    ENSEMBL proteins: 
     ENSP00000343952   ENSP00000339393   ENSP00000383715  
    Reactome Protein details: P51684

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    Cloud-Clone Corp. Proteins for CCR6

     
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    antibodies-online proteins for CCR6 (2 products) 

     
    antibodies-online peptides for CCR6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR6
    Chemokine receptors

    4 InterPro protein domains:
     IPR004067 Chemokine_CCR6
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P51684

    ProtoNet protein and cluster: P51684

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB004067 C-C chemokine receptor type 6 signature


    UniProtKB/Swiss-Prot: CCR6_HUMAN, P51684
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CCR6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR6_HUMAN, P51684
    Function: Receptor for a C-C type chemokine. Binds to MIP-3-alpha/LARC and subsequently transduces a signal by
    increasing the intracellular calcium ions level
    Induction: By IL2/interleukin-2

         Genatlas biochemistry entry for CCR6:
    chemokine CC beta receptor,expressed in lymphocyte and monocyte,highly homolog to EBI1,IL8RA,IL8RB,G protein
    coupled receptor superfamily

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9186513
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS11001880
    GO:0005515protein binding ----
    GO:0016493C-C chemokine receptor activity IEA--
         
    Find genes that share ontologies with CCR6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCR6:
     Decreased Hepatitis C virus re 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ccr6):
     hematopoietic system  homeostasis/metabolism  immune system  nervous system  normal 

    Find genes that share phenotypes with CCR6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CCR6: Ccr6tm1Lira Ccr6tm1Gma

       genOway: Develop your customized and physiologically relevant rodent model for CCR6

    miRNA
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    miRTarBase miRNAs that target CCR6:
    hsa-mir-26b-5p (MIRT029835)

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    6 qRT-PCR Assays for microRNAs that regulate CCR6:
    hsa-miR-3671 hsa-miR-607 hsa-miR-186* hsa-miR-518a-5p hsa-miR-450b-5p hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidCCR6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CCR6

    Gene Editing
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    Sino Biological Human cDNA Clone for CCR6
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCR6_HUMAN, P51684: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9186513
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with CCR6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCR6 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    5Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33


    Find genes that share SuperPaths with CCR6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCR6
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR6 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 BioSystems Pathways for CCR6
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    3 Reactome Pathways for CCR6
        Chemokine receptors bind chemokines
    G alpha (i) signalling events
    Beta defensins


    2 Kegg Pathways  (Kegg details for CCR6):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR6 (see all 8): 
              Innate & Adaptive Immune Responses in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Th17 Response in human mouse rat
              Insulin Resistance in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCR6 (P516843 ENSP000003393934) via UniProtKB, MINT, STRING, and/or I2D (see all 187)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DEFB103BP815343, ENSP000003246334I2D: score=1 STRING: ENSP00000324633
    DEFB4AO152633, ENSP000003035324I2D: score=1 STRING: ENSP00000303532
    DEFB103AP815343I2D: score=1 
    DEFB4BO152633I2D: score=1 
    CCL20P785563, ENSP000003516714I2D: score=3 STRING: ENSP00000351671
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002407dendritic cell chemotaxis TAS16621978
    GO:0006928cellular component movement TAS9186513
    GO:0006935chemotaxis TAS11001880
    GO:0006955immune response TAS9223454
    GO:0006959humoral immune response TAS11001880

    Find genes that share ontologies with CCR6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCR6

    1 HMDB Compound for CCR6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 IUPHAR Ligands for CCR6 (CCR6)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]CCL20
    AgonistFull agonist109294138
    CCL20-SEAP(His)6
    AgonistFull agonist99169459
    CCL20
    AgonistFull agonist7.9 - 8.59169459 12081481 9294137
    beta-defensin 4A
    AgonistFull agonist7.9 - 8.510521347

    8 Novoseek inferred chemical compound relationships for CCR6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    larc 89.5 20 9169459 (4), 11120783 (3), 11035086 (1), 9365118 (1) (see all 11)
    mip-3alpha 88 4 18490742 (1), 17617631 (1)
    rantes 65.3 6 10679062 (2), 17133532 (1), 11994442 (1), 9169459 (1)
    tarc 42.8 2 9365118 (1), 9169459 (1)
    ccl4 32.7 1 17133532 (1)
    calcium 9.12 4 9886385 (2), 10577517 (1), 16365449 (1)
    lipid 5.43 3 19928914 (2)
    vegf 5.24 2 15334073 (1), 16232215 (1)



    Find genes that share compounds with CCR6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCR6 gene (2 alternative transcripts): 
    NM_004367.5  NM_031409.3  

    Unigene Cluster for CCR6:

    Chemokine (C-C motif) receptor 6
    Hs.46468  [show with all ESTs]
    Unigene Representative Sequence: NM_031409
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341935(uc003qvn.4 uc003qvm.4) ENST00000349984 ENST00000400926(uc003qvl.3 uc010kkm.3)

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    6 qRT-PCR Assays for microRNAs that regulate CCR6:
    hsa-miR-3671 hsa-miR-607 hsa-miR-186* hsa-miR-518a-5p hsa-miR-450b-5p hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidCCR6 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CCR6

    Additional mRNA sequence: 

    AK223494.1 AK293015.1 AY242126.1 BC037960.1 U60000.1 U68030.1 U68031.1 

    5 DOTS entries:

    DT.121386105  DT.100749397  DT.95359744  DT.121386128  DT.432235 

    Selected AceView cDNA sequences (see all 78):

    BU193028 AA292126 AI566733 AA720658 NM_004367 BC037960 BM874378 NM_031409 
    AY242126 BG289619 BE550052 AW627471 AI627284 BU625682 AA442048 AA292127 
    BX097661 BF942057 CB306621 BQ427775 U68031 AW575605 AA865712 AW160364 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAATGTGG
    CCR6 Expression
    About this image


    CCR6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    CCR6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCR6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46468

    UniProtKB/Swiss-Prot: CCR6_HUMAN, P51684
    Tissue specificity: Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells
    but not in natural killer cells, monocytes or granulocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR6 (see all 8): 
              Innate & Adaptive Immune Responses in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Th17 Response in human mouse rat
              Insulin Resistance in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CCR6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCR6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr61 , 5 chemokine (C-C motif) receptor 61, 5 75.3(n)1
    75.2(a)1
      17 (4.90 cM)5
    124581  NM_001190338.11  NP_001177267.11 
     82360435 
    chicken
    (Gallus gallus)
    Aves CCR61 chemokine (C-C motif) receptor 6 63.38(n)
    60.28(a)
      769278  NM_001114081.1  NP_001107553.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCR66
    chemokine (C-C motif) receptor 6
    57(a)
    1 ↔ 1
    1(225500770-225508472)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ccr61 chemokine (C-C motif) receptor 6 57.2(n)
    50.7(a)
      100492892  XM_002935826.2  XP_002935872.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ccr6a1 chemokine (C-C motif) receptor 6a 56.1(n)
    48(a)
      558616  NM_001099991.1  NP_001093461.1 
    rice
    (Oryza sativa)
    Liliopsida Os.152852 Oryza sativa (japonica cultivar-group) cDNA clone0 more 80.46(n)    AK120580.1 


    ENSEMBL Gene Tree for CCR6 (if available)
    TreeFam Gene Tree for CCR6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCR6 gene
    CCR52  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  CCR72  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CCR6 using alignment to 1 protein entry:     CCR6_HUMAN(see all similar genes):
    CXCR1    CCR4    CXCR2    IL8RB    CCR7    CCR2
    CCR5    CCBP2    CCR8    CCR10    CCR9    ACKR4
    AGTR1    CCR1    CCR3    ACKR2    CCRL1    CXCR4

    Find genes that share paralogs with CCR6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCR6 (see all 737)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69076661,2
    C,F,A,H--167523395(+) ctgccG/Aatgca 1 -- us2k127Minor allele frequency- A:0.42NS EA NA WA CSA 2761
    rs1890519061,2
    --167523404(+) CACACA/GTCGGT 1 -- us2k10--------
    rs1156589801,2
    C,F--167523419(+) TCCATG/ATCTTG 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1929796841,2
    --167523445(+) CACTGG/TGATGT 1 -- us2k10--------
    rs1852151121,2
    --167523457(+) CTAGTA/GGCTGC 1 -- us2k10--------
    rs773200441,2
    C--167523463(+) GCTGCC/TTTAAT 1 -- us2k10--------
    rs766408591,2
    F--167523521(+) GACCCA/GCCTCC 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1896861801,2
    --167523555(+) ATGAGC/GAGCTT 1 -- us2k10--------
    rs1813394951,2
    --167523705(+) TCTGCC/TTGAAA 1 -- us2k10--------
    rs1179511811,2
    C,F--167523778(+) CACTCC/TGAAGT 1 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for CCR6 (167525295 - 167553184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CCR6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733220CNV Deletion23290073
    esv2664671CNV Deletion23128226
    esv21674CNV Loss19812545
    nsv469673CNV Loss16826518
    nsv7998CNV Loss18304495
    esv2752099CNV Gain17911159
    essv22845CNV CNV17122850
    dgv2033e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CCR6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCR6
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601835    OMIM disorders: --

    8 diseases for CCR6:    
    About MalaCards
    erdheim-chester disease    granulomatosis with polyangiitis    stromal keratitis    diffuse scleroderma
    limited scleroderma    pustulosis palmaris et plantaris    keratitis    squamous cell carcinoma of the head and neck

    2 diseases from the University of Copenhagen DISEASES database for CCR6:
    Rheumatoid arthritis     Psoriasis

    Find genes that share disorders with CCR6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCR6 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 42.7 8 20453841 (3), 12695561 (2), 16207316 (1)
    inflammation 41.7 7 16215992 (2), 17379855 (1), 19928914 (1), 17178254 (1) (see all 5)
    necrosis 41.5 2 19295614 (1), 11090084 (1)
    psoriasis 38.9 7 15315355 (3), 10843722 (1), 15550147 (1), 19659772 (1)
    b-all 36.7 1 11368435 (1)
    skin lesion 29 2 15315355 (1), 19659772 (1)
    tumors 27.6 19 18465142 (4), 16622267 (3), 15334073 (1), 19340288 (1) (see all 12)
    autoimmunity 26 2 20453841 (1), 18706444 (1)
    lymphoma 20.7 3 12514792 (2), 11368435 (1)
    lymphoproliferative disorders 19.8 3 12614207 (1), 15621766 (1), 11368435 (1)

    Genetic Association Database (GAD): CCR6
    Human Genome Epidemiology (HuGE) Navigator: CCR6 (20 documents)

    Export disorders for CCR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCR6 gene, integrated from 10 sources (see all 283):
    (articles sorted by number of sources associating them with CCR6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and RNA expression of two new human chemokine receptor-like genes. (PubMed id 8886020)1, 2, 3, 9 Zaballos A.... Marquez G. (Biochem. Biophys. Res. Commun. 1996)
    2. Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC. (PubMed id 9169459)1, 2, 9 Baba M.... Yoshie O. (J. Biol. Chem. 1997)
    3. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. (PubMed id 20453841)1, 4, 9 Kochi Y....Yamamoto K. (Nat. Genet. 2010)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    6. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
    7. Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. (PubMed id 20526339)1, 4 Quan C....Zhang X.J. (Nat. Genet. 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Common variants in FOXP1 are associated with generalized vitiligo. (PubMed id 20526340)1, 4 Jin Y....Spritz R.A. (Nat. Genet. 2010)
    10. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1235 HGNC: 1607 AceView: CCR6 Ensembl:ENSG00000112486 euGenes: HUgn1235
    ECgene: CCR6 Kegg: 1235 H-InvDB: CCR6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCR6 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCR6 gene:
    Search GeneIP for patents involving CCR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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