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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCR5 Gene

protein-coding GIFtS: 68
GCID: GC03P046386

chemokine (C-C motif) receptor 5 (gene/pseudogene)

(Previous name: chemokine (C-C motif) receptor 5 )
(Previous symbol: CMKBR5)

Explore 216 diseases affiliated with
CCR5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene)¹ ²		CCCKR5² ⁵
CMKBR5¹ ² ³ ⁵		Chemokine (C-C Motif) Receptor 5¹
CC-CKR-5¹ ² ³		C-C Chemokine Receptor Type 5²
IDDM22¹ ² ⁵		C-C Motif Chemokine Receptor 5 A159A²
CD195¹ ²		Chemokine Receptor CCR5²
CKR-5¹ ²		Chemr13¹
CKR5¹ ²		CHEMR13³
CCR-5² ³		C-C CKR-5³
HIV-1 Fusion Coreceptor² ³		CD195 Antigen³

External Ids:	HGNC: 1606¹	Entrez Gene: 1234²	Ensembl: ENSG00000160791⁷	OMIM: 601373⁵	UniProtKB: P51681³

Export aliases for CCR5 gene to outside databases

Previous GC identifers: GC03P045652 GC03P046230 GC03P046372

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCR5:

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane

protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to

be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this

gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte

chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory

protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression

of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in

granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster

region. Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681

Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and

subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of

granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1

R5 isolates

summary for CCR5:

Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed

migration of immune cells. Over fifty human chemokines have been identified that can be categorised into

four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine

residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface

of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are

classified according to the class of chemokines that they bind. The major function of chemokines is to

regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include

angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of

chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by

cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCR5 gene promoter:
STAT1 AP-1 p53 ATF-2 STAT3 c-Jun GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCR5 promoter sequence

Search SABiosciences Chromatin IP Primers for CCR5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21

CCR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR5 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P046386: view genomic region (about GC identifiers)

Start:	46,411,633 bp from pter	End:	46,417,697 bp from pter
Size:	6,065 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681 (See protein sequence)

Recommended Name: C-C chemokine receptor type 5

Size: 352 amino acids; 40524 Da

Subunit: Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha

and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is

required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Interacts with human

cytomegalovirus/HHV-5 protein UL78

Subcellular location: Cell membrane; Multi-pass membrane protein

6/8 PDB 3D structures from and Proteopedia for CCR5 (see all 8):

1ND8 (3D)

1NE0 (3D)

1OPN (3D)

1OPT (3D)

1OPW (3D)

2L87 (3D)

Secondary accessions: O14692 O14693 O14695 O14696 O14697 O14698 O14699 O14700 O14701 O14702 O14703

O14704 O14705 O14706 O14707 O14708 O15538 Q9UPA4

Explore the universe of human proteins at neXtProt for CCR5: NX_P51681

Post-translational modifications:

Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is

required for efficient binding of the chemokines, CCL3 and CCL4¹

O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which

contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a

T-antigen¹

Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry¹

Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51681

CCR5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000570.1 NP_001093638.1

ENSEMBL proteins:

ENSP00000292303 ENSP00000404881 ENSP00000343985

Reactome Protein details: P51681
Human Recombinant Protein Products:

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	Novus Biologicals CCR5 Proteins Novus Biologicals CCR5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CCR5

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	10415069
GO:0005768	endosome	IDA	10679098
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	10393923
GO:0009897	external side of plasma membrane	IDA	11278962

CCR5 for ontologies About GeneDecksing

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	ThermoFisher Antibodies for CCR5

Assay Products for CCR5:

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	GenScript Custom Assay Services for CCR5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCR5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCR5 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR002240 Chemokine_CCR5

IPR000355 Chemokine_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P51681

ProtoNet protein and cluster: P51681

2 Blocks protein families:

IPB000355 Chemokine receptor signature

IPB002240 C-C chemokine receptor type 5 signature

UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681

Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and

subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of

granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1

R5 isolates

Genatlas biochemistry entry for CCR5:

chemokine CC,beta,receptor 5,expressed in lymphoid organs and cells,with multiple transcripts with 5' end heterogeneity

and dual promoter usage,mediating macrophage-tropic strains of HIV-1 entry in CD4+ cells with a reduced risk of AIDS

lymphoma in patients with the CCR5-delta 32 mutation,G protein coupled receptor superfamily

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CCR5 Browse MicroRNA Expression Plasmids
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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR5:
		hsa-miR-629* hsa-miR-3660 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-1280 hsa-miR-1260
		SwitchGear 3'UTR luciferase reporter plasmid: CCR5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCR5
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR5

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IDA	12421915
GO:0004435	phosphatidylinositol phospholipase C activity	TAS	8663314
GO:0004950	chemokine receptor activity	TAS	10201901
GO:0005515	protein binding	IPI	15001559
GO:0015026	coreceptor activity	TAS	10469138

CCR5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CCR5:

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-outs for CCR5: Ccr5^tm1Kuz Ccr5^tm1Brv Ccr5^tm1Sush
15 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ccr5):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	hematopoietic system
homeostasis/metabolism	immune system	liver/biliary system	mortality/aging	muscle
nervous system	no phenotypic analysis	reproductive system	tumorigenesis	vision/eye

CCR5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Chemokine Signaling

Chemokine Signaling

1.00

Chemokine signaling pathway

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CCR5

	Selected targets of CREB1
	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR5 (see all 11)

	Chemokine Signaling
	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NF-kappaB Activation by Viruses

5 BioSystems Pathways for CCR5

	GPCRs, Other
	GPCRs, Class A Rhodopsin-like
	TCR Signaling Pathway
	Peptide GPCRs
	IL12-mediated signaling events

5/13 Reactome Pathways for CCR5 (see all 13)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Signaling by GPCR
	Early Phase of HIV Life Cycle
	GPCR ligand binding

4 Kegg Pathways (Kegg details for CCR5):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Endocytosis
	Toxoplasmosis

CCR5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCR5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/221 Interacting proteins for CCR5 (P51681^{2, 3} ENSP00000292303⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 221)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARL6IP5	O75915²^,³, ENSP00000273258⁴	MINT-58208 I2D: score=2 STRING: ENSP00000273258
CCL5	P13501²^,³, ENSP00000293272⁴	MINT-8416147 MINT-8416085 MINT-8416125 MINT-8416173 I2D: score=3 STRING: ENSP00000293272
PRAF2	O60831²^,³, ENSP00000365570⁴	MINT-58198 MINT-58199 MINT-58207 I2D: score=2 STRING: ENSP00000365570
CCL3L3	P16619³, ENSP00000367605⁴	I2D: score=4 STRING: ENSP00000367605
CCL3L1	P16619³	I2D: score=4

About this table

Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	IEP	12032188
GO:0002407	dendritic cell chemotaxis	TAS	16621978
GO:0002437	inflammatory response to antigenic stimulus	--	--
GO:0006816	calcium ion transport	IDA	8699119
GO:0006935	chemotaxis	TAS	10741397

CCR5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCR5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for CCR5

Compounds for CCR5 available from Tocris Bioscience About this table

Compound	Action	CAS #
Maraviroc	Selective CCR5 antagonist	[376348-65-1]
DAPTA	Chemokine receptor 5 (CCR5) antagonist	[106362-34-9]

1 HMDB Compound for CCR5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for CCR5 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Maraviroc	--	376348-65-1	target	antagonist	17139284 19692476 11752352 19098484 17016423 16298345

10/81 Novoseek chemical compound relationships for CCR5 gene (see all 81) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	94.3	578	11121442 (8), 9547333 (6), 12773479 (6), 15355933 (6) (see all 99)
maraviroc	88.4	64	19501260 (4), 18623908 (4), 19622053 (3), 16298345 (3) (see all 35)
ccl3	86.4	73	15567066 (2), 16105698 (2), 17888174 (2), 19790057 (2) (see all 54)
aplaviroc	83	51	19501260 (3), 15280474 (3), 19200175 (2), 15681411 (2) (see all 9)
vicriviroc	80	29	19075241 (7), 19303620 (6), 20172579 (1), 20373959 (1) (see all 9)
sdf 1	77.6	23	9833747 (4), 16478397 (2), 17560067 (2), 11334974 (2) (see all 16)
bicyclam	77.5	1	9733901 (1)
tak779	74.7	8	12496074 (4), 20065862 (1), 15761117 (1), 17408760 (1)
enfuvirtide	74.2	17	15113926 (2), 17545708 (2), 17485501 (2), 15956589 (1) (see all 12)
c-d4i	73	7	12208966 (2), 12487827 (2), 15857992 (1), 18799178 (1) (see all 5)

1 PharmGKB related drug/compound annotation for CCR5 gene

Drug/compound	PharmGKB Annotation
maraviroc	DL

About this table

Search CenterWatch for drugs/clinical trials and news about CCR5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCR5 gene (2 alternative transcripts):

NM_000579.3 NM_001100168.1

Unigene Cluster for CCR5:

Chemokine (C-C motif) receptor 5 (gene/pseudogene)

Hs.450802 [show with all ESTs]

Unigene Representative Sequence: NM_000579

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000292303 ENST00000445772(uc021wxb.1) ENST00000343801(uc003cpo.4 uc010hjd.3)

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		SwitchGear 3'UTR luciferase reporter plasmid: CCR5 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR5

Additional cDNA sequence:

AF011500.1 AF011501.1 AF011502.1 AF011503.1 AF011504.1 AF011505.1 AF011506.1 AF011507.1

AF011508.1 AF011509.1 AF011510.1 AF011511.1 AF011512.1 AF011513.1 AF011514.1 AF011515.1

AF011516.1 AF011517.1 AF011518.1 AF011519.1 AF011520.1 AF011521.1 AF011522.1 AF011523.1

AF011524.1 AF011525.1 AF011526.1 AF011527.1 AF011528.1 AF011529.1 AF011530.1 AF011531.1

AF011532.1 AF011533.1 AF011534.1 AF011535.1 AF011536.1 AF011537.1 AK292132.1 AK314882.1

BC038398.1 U54994.1 U57840.1

2 DOTS entries:

DT.311277 DT.100012036

24/57 AceView cDNA sequences (see all 57):

U57840 U54994 BX481558 AF011533 AF011505 AF011507 AF011526 BC038398

AA361339 AF011523 AF011528 AF011514 AF011511 AF011534 AW016034 AF011536

AF011506 AF011532 AF011524 AF011501 AI417775 AF011513 AF011502 AF011537

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCR5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTGTTGGG

About this image
See CCR5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCR5

SOURCE GeneReport for Unigene cluster: Hs.450802

UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681

Tissue specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell

line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low

levels in ovary and lung

SABiosciences Expression via Pathway-Focused PCR Arrays including CCR5 (see all 16):

HIV Host Response in human mouse rat

Multiple Sclerosis in human mouse rat

T-cell & B-cell Activation in human mouse rat

Cell Lineage Identification in human mouse rat

Chemokines & Receptors in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCR5 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCR5¹	chemokine (C-C motif) receptor 5	65.62(n) 62.85(a)		420695 NM_001045834.1 NP_001039299.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	57(a) 57(a)	many ↔ many many ↔ many	GL343324.1(448159-449136) GL343324.1(443935-445008)
zebrafish (Danio rerio)	Actinopterygii	LOC100005081¹	c-C chemokine receptor type 5-like	57.11(n) 45.73(a)		100005081 XM_001344184.3 XP_001344220.3

ENSEMBL Gene Tree for CCR5 (if available)
TreeFam Gene Tree for CCR5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCR5 gene

CCR6² CXCR6² CXCR3² XCR1² CCR9² CCBP2² CCRL2² CCR7²

CX3CR1² CCR8² CXCR2² CCRL1² CCR4² CCR1² CXCR1² CCR2²

CXCR5² CCR10² CCR3² CXCR4²

18/67 SIMAP similar genes for CCR5 using alignment to 49 protein entries: CCR5_HUMAN (see all proteins) (see all similar genes):

CCR-5 CCR2 CCR1 CCR3 CCR4 CX3CR1

CCBP2 CCR8 CMKLR1 CCR7 CCRL2 LTB4R

CXCR2 CCR6 GHSR CCR9 GPR18 C3AR1

CCR5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681

Polymorphism: Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1

(resistance or susceptibility to HIV-1) [MIM:609423]. Variations in CCR5 gene also influence the rate of progression

to AIDS after infection

Polymorphism: Ser-60 variant, a naturally occurring mutation in a conserved residue in the first intracellular domain

of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced

susceptibility to infection by microbes that depend on these molecules as their receptors

Polymorphism: Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection [MIM:610379]

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1800944^1,2	C,F,	non-pathogenic	86076282(+)	`GCGAGC/TAAGCT`	4	A V	mis¹		3		NA CSA	4608
rs1800452^1,2	C,F,	non-pathogenic	86076618(+)	`GCTTCG/AGTGTC`	4	/Q /R	mis¹		1		NA	4534
rs1800560^1,2	C,F,	pathogenic	86076983(+)	`ATGTGT/ACAACT`	4	/* /C	stg¹		1		NA	4536
rs1800940^1,2	C,F	pathogenic	86077106(+)	`AAAAGG/TCTGAA`	4	R S	mis¹		1		NA	4544
rs192002630^1,2		--	46409728(+)	`AGTCTA/CGAGTG`	2	--	us2k¹		0	--	--	--	--
rs140587963^1,2		--	46409935(+)	`ATTTCC/TCATGG`	2	--	us2k¹		0	--	--	--	--
rs7637813^1,2	C,F,	--	46410036(+)	`GTAACA/GCACAC`	2	--	us2k¹		17		NS NA EA WA CSA	585
rs142620835^1,2		--	46410279(+)	`CGCTAA/GCCCAC`	2	--	us2k¹		0	--	--	--	--
rs140523021^1,2		--	46410396(+)	`AATTGC/GCACAA`	2	--	us2k¹		0	--	--	--	--
rs2856757^1,2	C,F,	--	46410494(+)	`ACCAAA/CGTTGT`	2	--	us2k¹		4		NA	128

HapMap Linkage Disequilibrium report for CCR5 (46411633 - 46417697 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCR5: --
Human Gene Mutation Database (HGMD): CCR5

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCR5 for disorders           About GeneDecksing

OMIM gene information: 601373
OMIM disorders: 610379  609532  612522
UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681

Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22

(IDDM22) [MIM:612522]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to

ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result

from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications

that affect the eyes, kidneys, nerves, and blood vessels

20/216 diseases for CCR5 (see all 216): About MalaCards

hiv infection, resistance to diabetes mellitus, insulin-dependent, 22 west nile virus guillain-barre syndrome

erdheim-chester disease graft versus host disease hiv infection, susceptibility/resistance to immune-complex glomerulonephritis

b-cell non-hodgkin lymphoma periapical granuloma aids dementia complex diffuse large b-cell lymphoma

end stage renal failure hypersensitivity reaction type ii disease hematopoiesis lichen planus

non-hodgkin lymphoma aggressive nk cell leukemia mesangial proliferative glomerulonephritis human immunodeficiency virus infectious disease

5 diseases from the University of Copenhagen DISEASES database for CCR5:

Human immunodeficiency virus infectious disease Multiple sclerosis Rheumatoid arthritis Plague

Encephalitis

10/94 Novoseek disease relationships for CCR5 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	87.7	564	15047820 (3), 9367961 (3), 9160656 (2), 9261347 (2) (see all 99)
hiv infections	80.3	200	16905787 (4), 18221152 (3), 9768623 (3), 12815099 (2) (see all 99)
aids	71.4	181	16138573 (5), 10737431 (4), 15742159 (4), 11061652 (3) (see all 99)
virus infection	57.9	61	10196302 (3), 9261448 (1), 10364284 (1), 11369664 (1) (see all 51)
aids dementia complex	55.1	3	10575135 (2), 11115360 (1)
inflammation	54.4	71	18063698 (4), 16284650 (3), 19790057 (3), 11786428 (2) (see all 41)
viremia	46.9	9	19281308 (1), 9707408 (1), 15031787 (1), 15047820 (1) (see all 8)
multiple sclerosis	46.2	33	10665504 (2), 17884183 (2), 11160301 (1), 12874407 (1) (see all 31)
hiv encephalitis	44.3	3	11305873 (1), 12857973 (1)
rheumatoid arthritis	39.2	27	12699431 (2), 17963165 (2), 10323455 (2), 11160301 (1) (see all 22)

Genetic Association Database (GAD): CCR5
Human Genome Epidemiology (HuGE) Navigator: CCR5 (428 documents)

Export disorders for CCR5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCR5 gene, integrated from 9 sources (see all 2209):
(articles sorted by number of sources associating them with CCR5)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and functional expression of a new human CC- chemokine receptor gene. (PubMed id 8639485)^{1, 2, 3, 9} Samson M.... Parmentier M. (1996)
Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses. (PubMed id 9343222)^{1, 2, 9} Kuhmann S.E.... Kabat D. (1997)
Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. (PubMed id 10085131)^{1, 2, 9} Oppermann M....Olbrich H. (1999)
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. (PubMed id 16144840)^{1, 2, 9} Huttenrauch F....Oppermann M. (2005)
Distribution of human chemokine (C-X3-C) receptor 1 (CX3CR1) gene polymorphisms and haplotypes of the CC chemokine receptor 5 (CCR5) promoter in Chinese people, and the effects of CCR5 haplotypes on CCR5 expression. (PubMed id 15787642)^{1, 4, 9} Li C....Shieh B. (2005)
Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. (PubMed id 16140745)^{1, 4, 9} Hladik F....McElrath M.J. (2005)
Relative importance of CCR5 and antineutrophil cytoplasmic antibodies in patients with Wegener's granulomatosis. (PubMed id 12858455)^{1, 4, 9} Zhou Y....Hoffman G.S. (2003)
Characterization of sequence determinants within the carboxyl- terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization. (PubMed id 11448957)^{1, 2, 9} Kraft K.... Oppermann M. (2001)
Structural and functional characterization of the human CCR5 receptor in complex with HIV gp120 envelope glycoprotein and CD4 receptor by molecular modeling studies. (PubMed id 14517611)^{1, 2, 9} Liu S.... Sun Z. (2003)
CCR5 and CCR2 gene polymorphisms in hypertensive patients. (PubMed id 12680626)^{1, 4, 9} Mettimano M....Romano-Spica V. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1234	HGNC: 1606	AceView: CCR5	Ensembl:ENSG00000160791	euGenes: HUgn1234
ECgene: CCR5	Kegg: 1234	H-InvDB: CCR5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCR5	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CC_chemokine_receptors
Wikipedia	http://en.wikipedia.org/wiki/CCR5

Intellectual Property for CCR5 gene
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Patent Information for CCR5 gene:
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Licensable Technologies for CCR5 gene:

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CCR5 Gene

chemokine (C-C motif) receptor 5 (gene/pseudogene)

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chemokine (C-C motif) receptor 5 (gene/pseudogene)

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