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CCR5 Gene

protein-coding   GIFtS: 71
GCID: GC03P046386

Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene)

(Previous name: chemokine (C-C motif) receptor 5)
(Previous symbol: CMKBR5)
  See CCR5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene)1 2     CKR-52
CMKBR51 2 3 5     CKR52
CC-CKR-52 3     C-C Chemokine Receptor Type 52
CCR-52 3     C-C Motif Chemokine Receptor 5 A159A2
HIV-1 Fusion Coreceptor2 3     Chemokine Receptor CCR52
CCCKR52 5     chemr132
IDDM222 5     CHEMR133
Chemokine (C-C Motif) Receptor 51     C-C CKR-53
CD1952     CD195 Antigen3

External Ids:    HGNC: 16061   Entrez Gene: 12342   Ensembl: ENSG000001607917   OMIM: 6013735   UniProtKB: P516813   

Export aliases for CCR5 gene to outside databases

Previous GC identifers: GC03P045652 GC03P046230 GC03P046372


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCR5 Gene:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane
protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is
known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective
alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include
monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage
inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein
(RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein
may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine
receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CCR5 Gene:
CCR5 (chemokine (C-C motif) receptor 5 (gene/pseudogene)) is a protein-coding gene. Diseases associated with CCR5 include hepatitis c virus, and west nile virus. GO annotations related to this gene include actin binding and coreceptor activity. An important paralog of this gene is CCR6.

UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681
Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and
subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the
control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary
receptor) for HIV-1 R5 isolates

summary for CCR5 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCR5 gene promoter:
         STAT1   AP-1   p53   ATF-2   STAT3   c-Jun   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCR5 promoter sequence
   Search Chromatin IP Primers for CCR5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CCR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P046386:  view genomic region     (about GC identifiers)

Start:
46,411,633 bp from pter      End:
46,417,697 bp from pter
Size:
6,065 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681 (See protein sequence)
Recommended Name: C-C chemokine receptor type 5  
Size: 352 amino acids; 40524 Da
Subunit: Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to
CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications.
Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and
ARRB2. Interacts with human cytomegalovirus/HHV-5 protein UL78
Selected PDB 3D structures from and Proteopedia for CCR5 (see all 9):
1ND8 (3D)        1NE0 (3D)        1OPN (3D)        1OPT (3D)        1OPW (3D)        2L87 (3D)    
Secondary accessions: O14692 O14693 O14695 O14696 O14697 O14698 O14699 O14700 O14701 O14702
O14703 O14704 O14705 O14706 O14707 O14708 O15538 Q9UPA4

Explore the universe of human proteins at neXtProt for CCR5: NX_P51681

Explore proteomics data for CCR5 at MOPED

Post-translational modifications: 

  • Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is
    required for efficient binding of the chemokines, CCL3 and CCL41
  • O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which
    contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such
    as a T-antigen1
  • Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry1
  • Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by
    APO-RANTES1
  • Glycosylation2 at Ser6, Ser7, Thr16, Ser17
  • Modification sites at PhosphoSitePlus

  • See CCR5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000570.1  NP_001093638.1  

    ENSEMBL proteins: 
     ENSP00000292303   ENSP00000404881   ENSP00000343985  
    Reactome Protein details: P51681

    CCR5 Human Recombinant Protein Products:

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    Novus Biologicals CCR5 Proteins
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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for CCR5

     
    Search eBioscience for Proteins for CCR5 

    CCR5 Antibody Products:

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    CCR5 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCR5
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    Search eBioscience for ELISAs for CCR5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR5
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002240 Chemokine_CCR5
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P51681

    ProtoNet protein and cluster: P51681

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB002240 C-C chemokine receptor type 5 signature


    UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CCR5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR5_HUMAN, P51681
    Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and
    subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the
    control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary
    receptor) for HIV-1 R5 isolates

         Genatlas biochemistry entry for CCR5:
    chemokine CC,beta,receptor 5,expressed in lymphoid organs and cells,with multiple transcripts with 5' end
    heterogeneity and dual promoter usage,mediating macrophage-tropic strains of HIV-1 entry in CD4+ cells with a
    reduced risk of AIDS lymphoma in patients with the CCR5-delta 32 mutation,G protein coupled receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA12421915
    GO:0004435phosphatidylinositol phospholipase C activity TAS8663314
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS10201901
    GO:0005515protein binding IPI12421915
         
    Find genes that share ontologies with CCR5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCR5:
     Increased HPV18 LCR reporter a 

         15 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ccr5):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  no phenotypic analysis  reproductive system  tumorigenesis  vision/eye 

    Find genes that share phenotypes with CCR5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CCR5: Ccr5tm1Kuz Ccr5tm1Brv Ccr5tm1Sush

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR5

    miRNA
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    Block miRNA regulation of human, mouse, rat CCR5 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CCR5:
    hsa-miR-629* hsa-miR-3660 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-1280 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidCCR5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCR5
    Predesigned siRNA for gene silencing in human, mouse, rat CCR5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCR5

    Clone
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    OriGene clones in human, mouse for CCR5 (see all 13)
    OriGene ORF clones in mouse, rat for CCR5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCR5 (NM_000579)
    Sino Biological Human cDNA Clone for CCR5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR5

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13905) for CCR5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCR5_HUMAN, P51681: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    nucleus3
    extracellular2
    cytoskeleton1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10415069
    GO:0005768endosome IDA10679098
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10393923
    GO:0009897external side of plasma membrane IDA10679098

    Find genes that share ontologies with CCR5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCR5 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    5Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33


    Find genes that share SuperPaths with CCR5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCR5
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR5 (see all 11)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NF-kappaB Activation by Viruses

    5 BioSystems Pathways for CCR5
        GPCRs, Other
    TCR Signaling Pathway
    GPCRs, Class A Rhodopsin-like
    IL12-mediated signaling events
    Peptide GPCRs


    3 Reactome Pathways for CCR5
        Binding and entry of HIV virion
    Chemokine receptors bind chemokines
    G alpha (i) signalling events


    5 Kegg Pathways  (Kegg details for CCR5):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Endocytosis
    Toxoplasmosis
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR5 (see all 16): 
              HIV Host Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Cell Lineage Identification in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCR5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCR5 (P516811, 2, 3 ENSP000002923034) via UniProtKB, MINT, STRING, and/or I2D (see all 221)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL6IP5O759152, 3, ENSP000002732584MINT-58208 I2D: score=2 STRING: ENSP00000273258
    CCL5P135011, 2, 3, ENSP000002932724EBI-489374,EBI-2848366 MINT-8416147 MINT-8416085 MINT-8416125 MINT-8416173 I2D: score=3 STRING: ENSP00000293272
    PRAF2O608312, 3, ENSP000003655704MINT-58198 MINT-58199 MINT-58207 I2D: score=2 STRING: ENSP00000365570
    CCL3L3P166193, ENSP000003676054I2D: score=4 STRING: ENSP00000367605
    CCL4P132361, 3, ENSP000002501514EBI-489374,EBI-6625160 I2D: score=3 STRING: ENSP00000250151
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEP12032188
    GO:0001974blood vessel remodeling IEA--
    GO:0002407dendritic cell chemotaxis TAS16621978
    GO:0006816calcium ion transport IDA8699119
    GO:0006935chemotaxis TAS10741397

    Find genes that share ontologies with CCR5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CCR5
      Browse compounds at ApexBio 

    Compounds for CCR5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    1 HMDB Compound for CCR5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CCR5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Maraviroc-- 376348-65-1targetantagonist17139284 19692476 11752352 19098484 17016423 16298345

    Selected IUPHAR Ligands for CCR5 (CCR5) (see all 29)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCL5
    AgonistFull agonist9.2 - 9.716298345 10318947 9790730
    [125I]CCL4 (human)
    AgonistFull agonist9.616298345
    CCL4
    AgonistFull agonist9.4 - 9.616298345 9790730
    CCL8
    AgonistFull agonist9.39790730
    CCL13
    AgonistFull agonist9.19790730
    [3H]maraviroc
    AntagonistAntagonist9.116298345
    vicriviroc
    AntagonistAntagonist9.116304152
    CCL3
    AgonistFull agonist8 - 8.916298345 11170631 9790730
    [3H]ancriviroc
    AntagonistAntagonist8.916304152
    E913
    AntagonistAntagonist8.711454872

    Selected Novoseek inferred chemical compound relationships for CCR5 gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 94.3 578 11121442 (8), 9547333 (6), 12773479 (6), 15355933 (6) (see all 99)
    maraviroc 88.4 64 19501260 (4), 18623908 (4), 19622053 (3), 16298345 (3) (see all 35)
    ccl3 86.4 73 15567066 (2), 16105698 (2), 17888174 (2), 19790057 (2) (see all 54)
    aplaviroc 83 51 19501260 (3), 15280474 (3), 19200175 (2), 15681411 (2) (see all 9)
    vicriviroc 80 29 19075241 (7), 19303620 (6), 20172579 (1), 20373959 (1) (see all 9)
    sdf 1 77.6 23 9833747 (4), 16478397 (2), 17560067 (2), 11334974 (2) (see all 16)
    bicyclam 77.5 1 9733901 (1)
    tak779 74.7 8 12496074 (4), 20065862 (1), 15761117 (1), 17408760 (1)
    enfuvirtide 74.2 17 15113926 (2), 17545708 (2), 17485501 (2), 15956589 (1) (see all 12)
    c-d4i 73 7 12208966 (2), 12487827 (2), 15857992 (1), 18799178 (1) (see all 5)

    1 PharmGKB related drug/compound annotation for CCR5 gene    About this table
    Drug/compound PharmGKB Annotation
    maraviroc



    Find genes that share compounds with CCR5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCR5 gene (2 alternative transcripts): 
    NM_000579.3  NM_001100168.1  

    Unigene Cluster for CCR5:

    Chemokine (C-C motif) receptor 5 (gene/pseudogene)
    Hs.450802  [show with all ESTs]
    Unigene Representative Sequence: NM_000579
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000292303 ENST00000445772(uc021wxb.1) ENST00000343801(uc003cpo.4 uc010hjd.3)

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate CCR5:
    hsa-miR-629* hsa-miR-3660 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-1280 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidCCR5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCR5 (NM_000579)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR5
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    eBioscience FlowRNA Probe Sets ( VA1-13905) for CCR5 

    Additional mRNA sequence: 

    AF011500.1 AF011501.1 AF011502.1 AF011503.1 AF011504.1 AF011505.1 AF011506.1 AF011507.1 
    AF011508.1 AF011509.1 AF011510.1 AF011511.1 AF011512.1 AF011513.1 AF011514.1 AF011515.1 
    AF011516.1 AF011517.1 AF011518.1 AF011519.1 AF011520.1 AF011521.1 AF011522.1 AF011523.1 
    AF011524.1 AF011525.1 AF011526.1 AF011527.1 AF011528.1 AF011529.1 AF011530.1 AF011531.1 
    AF011532.1 AF011533.1 AF011534.1 AF011535.1 AF011536.1 AF011537.1 AK292132.1 AK314882.1 
    BC038398.1 U54994.1 U57840.1 

    2 DOTS entries:

    DT.311277  DT.100012036 

    Selected AceView cDNA sequences (see all 57):

    U54994 U57840 AF011505 AF011533 AA287788 BX482273 AF011510 AF011530 
    AF011536 AF011503 AF011508 BX481558 NM_000579 AF011525 AI417775 BQ184010 
    AF011501 AF011511 AF011534 AF011514 AF011509 AF011535 AF011518 AF011521 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTGTTGGG
    CCR5 Expression
    About this image


    CCR5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    CCR5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCR5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.450802

    UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681
    Tissue specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic
    cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small
    intestine. Low levels in ovary and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR5 (see all 16): 
              HIV Host Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Cell Lineage Identification in human mouse rat
              Chemokines & Receptors in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat CCR5
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CCR5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr51 , 5 chemokine (C-C motif) receptor 51, 5 84.19(n)1
    82.39(a)1
      9 (75.05 cM)5
    127741  NM_009917.51  NP_034047.21 
     1241215435 
    chicken
    (Gallus gallus)
    Aves CCR56
    CCR26
    Gallus gallus chemokine (C-C motif) receptor 5 (CC...
    Gallus gallus chemokine (C-C motif) receptor 2 (CC...
    59(a)
    56(a)
    many ↔ many
    many ↔ many
    2(43257827-43263465)
    2(43274889-43275953)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    57(a)
    57(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343324.1(448159-449136)
    GL343324.1(443935-445008)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017319801 c-C chemokine receptor type 5-like 60.6(n)
    55.82(a)
      101731980  XM_004915349.1  XP_004915406.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000050811 c-C chemokine receptor type 5-like 56.54(n)
    44.17(a)
      100005081  XM_001344184.4  XP_001344220.4 


    ENSEMBL Gene Tree for CCR5 (if available)
    TreeFam Gene Tree for CCR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCR5 gene
    CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  CCR72  
    ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CCR5 using alignment to 49 protein entries:     CCR5_HUMAN (see all proteins) (see all similar genes):
    CCR-5    CCR2    CCR1    CCR3    CCR4    CX3CR1
    ACKR2    CCR8    CCBP2    CMKLR1    CCR7    CCRL2
    LTB4R    CXCR2    CCR6    GHSR    CCR9    GPR18

    Find genes that share paralogs with CCR5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CCR5_HUMAN, P51681: Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1
    (resistance or susceptibility to HIV-1) [MIM:609423]. Variations in CCR5 gene also influence the rate of
    progression to AIDS after infection
    CCR5_HUMAN, P51681: Ser-60 variant, a naturally occurring mutation in a conserved residue in the first intracellular
    domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with
    reduced susceptibility to infection by microbes that depend on these molecules as their receptors
    CCR5_HUMAN, P51681: Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection
    [MIM:610379]


    Selected SNPs for CCR5 (see all 294)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18004521,2,,4
    C,Fnon-pathogenic146345614(+) GCTTCG/AGTGTC 4 /Q /R mis11Minor allele frequency- A:0.00NA 4534
    rs18009441,2,,4
    C,Fnon-pathogenic146345950(+) GCGAGC/TAAGCT 4 A V mis13Minor allele frequency- T:0.01NA CSA 4608
    rs18009401,2,,4
    C,Fpathogenic146345126(+) AAAAGG/TCTGAA 4 R S mis11Minor allele frequency- T:0.00NA 4544
    rs18005601,2
    C,Fpathogenic146345249(+) ATGTGT/ACAACT 4 /* /C stg11Minor allele frequency- A:0.00NA 4536
    rs31365361,2
    C,F,H--46340198(+) AGGTGC/TAGTGA 2 -- us2k113Minor allele frequency- T:0.07NA NS EA 1540
    rs1920026301,2
    --46340290(+) AGTCTA/CGAGTG 2 -- us2k10--------
    rs1405879631,2
    --46340497(+) ATTTCC/TCATGG 2 -- us2k10--------
    rs414913451,2
    C--46340582(+) GAAACA/GCAAAA 2 -- us2k10--------
    rs76378131,2
    C,F--46340598(+) GTAACA/GCACAC 2 -- us2k117Minor allele frequency- G:0.22NS NA EA WA CSA 585
    rs414906451,2
    C--46340699(+) CATGTA/CGTATT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCR5 (46411633 - 46417697 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCR5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271120CNV Insertion20981092
    nsv876734CNV Gain21882294

    Human Gene Mutation Database (HGMD): CCR5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCR5
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601373   
    OMIM disorders: 610379  609532  612522  
    UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681
  • Diabetes mellitus, insulin-dependent, 22 (IDDM22) [MIM:612522]: A multifactorial disorder of glucose
    homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical
    features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and
    secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and
    blood vessels. Note=Disease susceptibility is associated with variations affecting the gene represented in this
    entry

  • Selected diseases for CCR5 (see all 21):    
    About MalaCards
    hepatitis c virus    west nile virus    diabetes mellitus, insulin-dependent, 22    hiv infection, susceptibility/
    syphilis    whiplash    intermediate uveitis    secondary syphilis
    cytomegalovirus retinitis    erdheim-chester disease    mesangial proliferative glomerulonephritis    hiv-1
    periapical granuloma    alexithymia    polyradiculoneuropathy    uveitis
    chagas disease    glomerulonephritis    behcet's disease    influenza

    4 diseases from the University of Copenhagen DISEASES database for CCR5:
    Acquired immunodeficiency syndrome     Multiple sclerosis     Rheumatoid arthritis     Asthma

    Find genes that share disorders with CCR5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCR5 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 87.7 564 15047820 (3), 9367961 (3), 9160656 (2), 9261347 (2) (see all 99)
    hiv infections 80.3 200 16905787 (4), 18221152 (3), 9768623 (3), 12815099 (2) (see all 99)
    aids 71.4 181 16138573 (5), 10737431 (4), 15742159 (4), 11061652 (3) (see all 99)
    virus infection 57.9 61 10196302 (3), 9261448 (1), 10364284 (1), 11369664 (1) (see all 51)
    aids dementia complex 55.1 3 10575135 (2), 11115360 (1)
    inflammation 54.4 71 18063698 (4), 16284650 (3), 19790057 (3), 11786428 (2) (see all 41)
    viremia 46.9 9 19281308 (1), 9707408 (1), 15031787 (1), 15047820 (1) (see all 8)
    multiple sclerosis 46.2 33 10665504 (2), 17884183 (2), 11160301 (1), 12874407 (1) (see all 31)
    hiv encephalitis 44.3 3 11305873 (1), 12857973 (1)
    rheumatoid arthritis 39.2 27 12699431 (2), 17963165 (2), 10323455 (2), 11160301 (1) (see all 22)

    Genetic Association Database (GAD): CCR5
    Human Genome Epidemiology (HuGE) Navigator: CCR5 (428 documents)

    Export disorders for CCR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCR5 gene, integrated from 10 sources (see all 2266):
    (articles sorted by number of sources associating them with CCR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of a new human CC- chemokine receptor gene. (PubMed id 8639485)1, 2, 3, 9 Samson M.... Parmentier M. (Biochemistry 1996)
    2. Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses. (PubMed id 9343222)1, 2, 9 Kuhmann S.E.... Kabat D. (J. Virol. 1997)
    3. Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. (PubMed id 10085131)1, 2, 9 Oppermann M.... Olbrich H. (J. Biol. Chem. 1999)
    4. G protein-coupled receptor kinases promote phosphorylation and beta- arrestin-mediated internalization of CCR5 homo- and hetero- oligomers. (PubMed id 16144840)1, 2, 9 Huettenrauch F.... Oppermann M. (J. Biol. Chem. 2005)
    5. Distribution of human chemokine (C-X3-C) receptor 1 (CX3CR1) gene polymorphisms and haplotypes of the CC chemokine receptor 5 (CCR5) promoter in Chinese people, and the effects of CCR5 haplotypes on CCR5 expression. (PubMed id 15787642)1, 4, 9 Li C....Shieh B. (Int. J. Immunogenet. 2005)
    6. Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi. (PubMed id 20169157)1, 4, 9 Joubert B.R....Meshnick S.R. (PLoS ONE 2010)
    7. Rapid determination of the Delta32 deletion in the human CC-chemokine receptor 5 (CCR5) gene without DNA extraction by lightcycler real-time polymerase chain reaction. (PubMed id 15307921)1, 4, 9 Nischalke H.D....Spengler U. (AIDS Res. Hum. Retroviruses 2004)
    8. Polymorphisms in CCR5 chemokine receptor gene in Japan. (PubMed id 17845302)1, 4, 9 Liu H....Shioda T. (Int. J. Immunogenet. 2007)
    9. Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. (PubMed id 16140745)1, 4, 9 Hladik F....McElrath M.J. (J. Virol. 2005)
    10. Relative importance of CCR5 and antineutrophil cytoplasmic antibodies in patients with Wegener's granulomatosis. (PubMed id 12858455)1, 4, 9 Zhou Y....Hoffman G.S. (J. Rheumatol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1234 HGNC: 1606 AceView: CCR5 Ensembl:ENSG00000160791 euGenes: HUgn1234
    ECgene: CCR5 Kegg: 1234 H-InvDB: CCR5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCR5 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors
    Wikipedia http://en.wikipedia.org/wiki/CCR5

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCR5 gene:
    Search GeneIP for patents involving CCR5

    Licensable Technologies for CCR5 gene:
     Salk Institute: Alpha-Complementation Viral Fusion Assay
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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