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CCR5 Gene

protein-coding   GIFtS: 69

GC03P046386
chemokine (C-C motif) receptor 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CMKBR5)
Services    

Aliases &
Descriptions
for CCR5

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CC-CKR-5 1, 2, 3
CCCKR5 2, 5
CCR-5 3
CD195 1, 2
CHEMR13 3
CKR-5 1, 2
CKR5 1, 2
CMKBR5 2, 3, 5
FLJ78003 2
IDDM22 2, 5
chemr13 2
Descriptions
C-C CKR-5 3
C-C chemokine receptor type 5 2
C-C motif chemokine receptor 5 A159A 2
CD195 antigen 3
HIV-1 fusion coreceptor 3
chemokine (C-C motif) receptor 5 2
chemokine receptor CCR5 2
External Ids
HGNC: 16061
Entrez Gene: 12342
UniProtKB: P516813
Ensembl: ENSG000001607917
Search outside databases for aliases for CCR5 gene

Previous GC identifers: GC03P045652 GC03P046230 GC03P046372

Summaries
for CCR5

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for CCR5:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven
transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells
and macrophages, and is known to be an important co-receptor for macrophage-tropic virus,
including HIV, to enter host cells. Defective alleles of this gene have been associated with the
HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2
(MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1
beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES).
Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this
protein may play a role in granulocyte lineage proliferation and differentiation. This gene is
located at the chemokine receptor gene cluster region. Two transcript variants encoding the same
protein have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681
Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and
RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May
play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a
coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates

Gene Wiki entry for CCR5

Genomic Location
for CCR5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CCR5 gene  

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CCR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P046386:     (about GC identifiers)

Start:
 46,386,637 bp from pter
End:
 46,392,701 bp from pter
Size:
 6,065 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000003.10  NT_022517.17  NT_113884.1  

Proteins
for CCR5

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681 (See protein sequence)
Recommended Name: C-C chemokine receptor type 5  
Size: 352 amino acids; 40524 Da
Subunit: Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding
to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid
modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with
ADRBK1
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structures from and Proteopedia :
1ND8 (3D)    1NE0 (3D)    1OPN (3D)    1OPT (3D)    1OPW (3D)    2RLL (3D)    
Secondary accessions: O14692 O14693 O14695 O14696 O14697 O14698 O14699 O14700 O14701 O14702 O14703
O14704 O14705 O14706 O14707 O14708 O15538 Q9UPA4

Post-translational modifications:

  • Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of
    HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL41
  • O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans
    present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if
    so, with small moieties such as a T-antigen1
  • Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent,
    for HIV entry1
  • Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines
    especially by APO-RANTES1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_000570.1  NP_001093638.1  NP_001099006.1  


    ENSEMBL proteins: 
    ENSP00000292303 ENSP00000343985 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant CCR5 Protein
    Sigma-Aldrich CompoZr ZFN for CCR5  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (CCR5)
    Human Recombinant Proteins from Abnova (CCR5)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm TAS10415069
    GO:0005768 endosome TAS10679098
    GO:0005886 plasma membrane TAS10201901
    GO:0005887 integral to plasma membrane TAS10393923
    GO:0009897 external side of plasma membrane IDA11278962
    About this table

    Antibodies for CCR5: 
    Invitrogen Antibodies for CCR5
    Millipore Mono- and Polyclonal Antibodies for the study of CCR5
    Sigma-Aldrich Antibodies for CCR5
    R&D Systems Antibodies for CCR5
    Antibodies from Abcam (CCR5), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (CCR5)
    Novus Biologicals Antibodies for CCR5

    Assays for CCR5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for CCR5

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR002240 CC_5_rcpt
     IPR000276 7TM_GPCR_Rhodpsn
     IPR000355 Chmkine_rcpt


       GeneDecks  CCR5 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P51681

    ProtoNet protein and cluster: P51681

    2 Blocks protein families:
    IPB000355 Chemokine receptor signature
    IPB002240 C-C chemokine receptor type 5 signature


    UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681
    Similarity: Belongs to the G-protein coupled receptor 1 family

    Gene Function
    for CCR5

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CCR5)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000579

                  Applied Biosystems Silencer® siRNAs for CCR5

                  Sigma-Aldrich siRNA and siRNA Panels for CCR5  
                         Sigma-Aldrich shRNA Panels and shRNA for CCR5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for CCR5
    Millipore Clones for the Expression of CCR5
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000579
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000579
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000579 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000579

    UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681
    Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and
    RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May
    play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a
    coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates

    Genatlas biochemistry entry for CCR5:
    chemokine CC,beta,receptor 5,expressed in lymphoid organs and cells,with multiple transcripts with
    5' end heterogeneity and dual promoter usage,mediating macrophage-tropic strains of HIV-1 entry in
    CD4+ cells with a reduced risk of AIDS lymphoma in patients with the CCR5-delta 32 mutation,G
    protein coupled receptor superfamily

    6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ccr5):

    behavior/neurologicaldigestive/alimentaryhematopoietic systemhomeostasis/metabolism
    immune system

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779 actin binding IDA12421915
    GO:0004435 phosphoinositide phospholipase C activity TAS8663314
    GO:0004930 G-protein coupled receptor activity IEA--
    GO:0005515 protein binding IPI12421915 15001559
    GO:0015026 coreceptor activity TAS10469138
    About this table

    Pathways & Interactions
    for CCR5

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for CCR5 (Maps provided by GeneGo):
     Chemokine signaling

       GeneDecks  CCR5 for the pathways selected above  
    About GeneDecksing

    2 Millipore Pathways for CCR5
     Selected targets of CREB1
     Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

       GeneDecks  CCR5 for the pathways selected above  
    About GeneDecksing

    5 Sigma-Aldrich "Your Favorite Gene" Pathways for  CCR5  (Your Favorite Gene powered by Ingenuity) 
     NF-&kappa
     IL-10 Signaling
     CCR5 Signaling in Macrophages
     Hepatic Fibrosis / Hepatic Stellate Cell Activation
     Chemokine Signaling

       GeneDecks  CCR5 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for CCR5):
     hsa04060 Cytokine-cytokine receptor interaction

       GeneDecks  CCR5 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  CCR5 


    5/145 Interacting proteins for CCR5 (ENSP000002923033 P516811, 2) via UniProtKB, MINT, and/or STRING (see all 145 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRAF2O608312STRING (score=.964) MINT-58198 MINT-58199 MINT-58207
    ARL6IP5O759152STRING (score=.756) MINT-58208
    MYH9P355791EBI-489374, EBI-350338
    CCL3ENSP000002252453STRING (score=.999)
    CCL4ENSP000002501513STRING (score=.999)
    About this table

    5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935 chemotaxis TAS10741397
    GO:0006954 inflammatory response TAS8639485
    GO:0006955 immune response TAS8639485
    GO:0006968 cellular defense response TAS10201901
    GO:0007186 G-protein coupled receptor protein signaling pathway TAS10393923
    About this table

    Drugs & Compounds
    for CCR5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Compounds for CCR5 available from Tocris Bioscience
    CompoundAction CAS number
    DAPTAChemokine receptor 5 (CCR5) antagonist[106362-34-9]
    About this table


    10/37 Novoseek chemical compound relationships for CCR5 gene (see all 37 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 94.51 566 11121442 (8), 9547333 (6), 12773479 (6), 15355933 (6) (see all 99)
    maraviroc 87.28 48 18623908 (4), 16298345 (3), 16329283 (2), 17927288 (2) (see all 26)
    ccl3 86.17 63 15567066 (2), 16105698 (2), 17888174 (2), 12547595 (1) (see all 47)
    vicriviroc 81.66 26 19075241 (7), 19303620 (6), 18519143 (1), 17933730 (1) (see all 7)
    aplaviroc 80.77 46 15280474 (3), 19200175 (2), 16476734 (2), 15681411 (2) (see all 8)
    sdf 1 77.02 23 9833747 (4), 16478397 (2), 17560067 (2), 11334974 (2) (see all 16)
    c-d4i 72.00 6 12208966 (2), 12487827 (2), 15857992 (1), 18799178 (1)
    dapta 71.64 6 16002156 (4), 15043212 (1)
    mdms 69.44 18 10555107 (3), 11920312 (3), 12699419 (1), 15302954 (1) (see all 9)
    ccl4 68.48 53 14761932 (2), 15567066 (2), 15848520 (2), 14533004 (1) (see all 37)
    About this table


    Transcripts
    for CCR5

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CCR5)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000579

                  Sigma-Aldrich siRNA and siRNA Panels for CCR5  
                         Sigma-Aldrich shRNA Panels and shRNA for CCR5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000579  NM_001100168  

    REFSEQ mRNAs for CCR5 gene (3 alternative transcripts): 

    NM_000579.3   NM_001100168.1   NM_001105536.1   

    NM_000579  NM_001100168  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000579
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000579
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000579 

    Additional cDNA sequence: 

    AK292132.1 AK314882.1 U54994.1 

    2 DOTS entries:

    DT.311277  DT.100012036 

    24/57 AceView cDNA sequences (see all 57 ):

    U57840 U54994 AF011501 AF011532 AF011516 NM_000579 BC038398 AW016034 
    AI948825 AF011520 AF011530 AF011518 AA361339 BX482273 AF011529 AF011534 
    AF011500 AF011504 AF011510 AF011528 BQ184010 BI764263 AF011531 AF011507 

    highest scoring ESTs for CCR5:

    AA287788 AA361339 AF011500 AF011501 AF011502 AF011503 AF011504 AF011505 AF011506 AF011507 

    Unigene Clusters for CCR5:

    Chemokine (C-C motif) receptor 5
    Hs.450802  [show with all ESTs], Hs.536735  [show with all ESTs]
    Unigene Representative Sequences: NM_000579, U54994


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000292303  ENST00000343801  

    Expression
    for CCR5

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CCR5 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CCR5

    1 / 2 / 3

    3 probe-sets matching CCR5 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		36724_s_at2, 3 U95-A 2 1.00 0.50 1.00 1.00 U95626 0.20 0.17 0.18 1

    		206991_s_at2, 3 U133-A 2 1.00 0.50 -- -- NM_000579 0.60 1.00 0.82 1

    		206991_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.450802 Hs.536735

    Expression variation in blood from EXPOLDB for CCR5

    UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681
    Tissue specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the
    promyeloblastic cell line KG-1A and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood
    leukocytes and in small intestine. Low levels in ovary and lung

    Orthologs
    for CCR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for CCR5 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 CCR51   -- chemokine (C-C motif) receptor 5 84(n)
    82.67(a)    		 484789  NM_001012342.2  NP_001012342.2 
    chimpanzee
    (Pan troglodytes)    		 CCR51   -- chemokine (C-C motif) receptor 5 99.34(n)
    99.43(a)    		 450128  NM_001009046.1  NP_001009046.1 
    cow
    (Bos taurus)    		 CCR51   -- chemokine (C-C motif) receptor 5 86.74(n)
    86.08(a)    		 497017  NM_001011672.2  NP_001011672.2 
    rat
    (Rattus norvegicus)    		 Ccr51   -- chemokine (C-C motif) receptor 5 84.09(n)
    82.67(a)    		 117029  NM_053960.3  NP_446412.2 
    mouse
    (Mus musculus)    		 Ccr51, 5 9 (72.00 cM)5
    		 chemokine (C-C motif) receptor 51, 5 84.19(n)1
    82.39(a)1    		 127741  NM_009917.31  NP_034047.21 
     AF0197725  AF0229905  (see all 23)
    About this table        Species with no ortholog for CCR5

    ENSEMBL Gene Tree for CCR5

    Paralogs
    for CCR5

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CCR5 gene
    LOC7277971  CCRL22  ENSG000002157822  ENSG000002157782  CCR42  CCR12  CCR22  CCR32  
    ENSG000002157752  

    SNPs/Variants
    for CCR5

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681
    Polymorphism: Variations in CCR5 are associated with resistance or susceptibility to
    immunodeficiency virus type 1 (resistance or susceptibility to HIV-1) [MIM:609423]. Variations in
    CCR5 gene also influence the rate of progression to AIDS after infection
    Polymorphism: Ser-60 variant, a naturally occurring mutation in a conserved residue in the first
    intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and
    consequently may be associated with reduced susceptibility to infection by microbes that depend on
    these molecules as their receptors
    Polymorphism: Variations in CCR5 are associated with susceptibility to West Nile virus (WNV)
    infection [MIM:610379]


    10/14 NCBI SNPs in CCR5 are shown (see all 14 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 7)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs31365361,2
    		C,F,H46384640(+) AGGTGC/TAGTGA 2 -- ng519Minor allele frequency- T:0.04NA EU EA WA 876
    rs76378131,2
    		C,F46385040(+) GTAACA/GCACAC 2 -- ng519Minor allele frequency- G:0.19NS NA EA 455
    --
    rs557899631,2
    		--46384640(+) AGGTGC/TAGTGA 2 -- ng510--------
    --
    rs414995501,2
    		--46385310(+) GAGTAC/TGTCTT 2 -- ng510--------
    --
    rs414693511,2
    		--46387266(+) ACCTTC/TAGACC 2 -- ut51 int10--------
    --
    rs414906451,2
    		--46385141(+) CATGTA/CGTATT 2 -- ng510--------
    --
    rs726229241,2
    		--46385498(+) ACCAAA/CGTTGT 2 -- ng510--------
    --
    rs598322531,2
    		--46384640(+) AGGTGC/TAGTGA 2 -- ng510--------
    --
    rs414129481,2
    		--46385511(+) TTATGC/TTATCT 2 -- ng510--------
    --
    rs413864451,2
    		--46385487(+) TCTTTC/TGAAAA 2 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for CCR5 (up to first 250kb)

    Disorders & Mutations
    for CCR5

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 601373

    UniProtKB/Swiss-Prot: CCR5_HUMAN, P51681

  • Genetic variation in CCR5 is associated with suseptibility to insulin-dependent diabetes
    mellitus type 22 (IDDM22) [MIM:612522]. IDDM is caused by the body's own immune system which
    destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia,
    polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis

    • 10/97 Novoseek disease relationships for CCR5 gene (see all 97 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 87.90 548 15047820 (3), 9367961 (3), 9160656 (2), 9261347 (2) (see all 99)
    hiv infections 79.88 181 16905787 (4), 18221152 (3), 9768623 (3), 12815099 (2) (see all 99)
    aids 70.68 170 16138573 (5), 10737431 (4), 15742159 (4), 11061652 (3) (see all 99)
    virus infection 57.80 57 10196302 (3), 9261448 (1), 10364284 (1), 11369664 (1) (see all 48)
    aids dementia complex 56.31 3 10575135 (2), 11115360 (1)
    inflammation 52.64 54 18063698 (4), 16284650 (3), 11786428 (2), 15967376 (2) (see all 33)
    viremia 47.85 9 19281308 (1), 9707408 (1), 15031787 (1), 15047820 (1) (see all 8)
    multiple sclerosis 47.07 32 10665504 (2), 17884183 (2), 11160301 (1), 12874407 (1) (see all 30)
    hiv encephalitis 45.33 3 11305873 (1), 12857973 (1)
    rheumatoid arthritis 38.00 26 12699431 (2), 17963165 (2), 10323455 (2), 11160301 (1) (see all 21)
    About this table

    Human Gene Mutation Database: CCR5
    Genetic Association Database: CCR5
    Human Genome Epidemiology Navigator: CCR5 (341 documents)

    Medical News
    for CCR5

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for CCR5

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/1815 PubMed articles for CCR5 gene (see all 1815 ):

    Search for CCR5

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCR5

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 1234 HGNC: 1606 AceView: CCR5 Ensembl:ENSG00000160791 euGenes: HUgn1234
    ECgene: CCR5 H-InvDB: CCR5

    Other Databases showing CCR5

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing CCR5

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors
    Wikipedia http://en.wikipedia.org/wiki/CCR5

    Licensable Technologies
    for CCR5

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		Licensable Technologies for CCR5 gene:
     Salk Institute: Alpha-Complementation Viral Fusion Assay

    Services
    for CCR5

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CCR5:
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