CCR4 Gene
protein-coding GIFtS: 63
GCID: GC03P032968
|
|
chemokine (C-C motif) receptor 4
| |
Aliases
for CCR4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chemokine (C-C Motif) Receptor 41 2 | | K5-52 3 | | CMKBR41 2 3 5 | | C-C CKR-42 3 | | CC-CKR-41 2 3 | | K5-52 3 | | CKR41 2 5 | | HGCN:140992 | | CD1941 2 | | C-C Chemokine Receptor Type 42 | | ChemR131 2 | | Chemokine (C-C) Receptor 42 | | CCR-42 3 | | CD194 Antigen3 |
Export aliases for CCR4 gene to outside databasesPrevious GC identifers: GC03U990019 GC03P032841 GC03P032966 GC03P032964 |
Summaries
for CCR4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCR4:
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CCchemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related moleculesthat regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in thedevelopment, homeostasis, and function of the immune system, and they have effects on cells of the central nervoussystem as well as on endothelial cells involved in angiogenesis or angiostasis. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679Function: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor ismediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as achemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates.In the CNS, could mediate hippocampal-neuron survival
 summary
for CCR4: Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.
Gene Wiki entry for CCR4
|
Genomic Views
for CCR4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCR4 gene promoter:
AhR STAT1 Pax-2 Pax-2a POU6F1 (c2) XBP-1 c-Ets-1 PPAR-alpha Pax-2b Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCR4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p24 Ensembl cytogenetic band: 3p22.3 HGNC cytogenetic band: 3p24-p21.3CCR4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P032968: view genomic region
(about GC identifiers)
Start:
|
32,993,066 bp from pter |
End:
|
32,997,841 bp from pter |
Size:
|
4,776 bases |
Orientation:
|
plus strand |
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Proteins
for CCR4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679 (See
protein sequence)Recommended Name: C-C chemokine receptor type 4 Size: 360 amino acids; 41403 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q9ULY6 Q9ULY7Explore the universe of human proteins at neXtProt for CCR4: NX_P51679
Post-translational modifications:
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably bybeta-adrenergic receptor kinases 1 and 21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51679
CCR4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005499.1
ENSEMBL proteins: ENSP00000332659 Reactome Protein details: P51679
Human Recombinant Protein Products for CCR4:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CCR4 for ontologies About GeneDecksing
CCR4 Antibody Products:
Assay Products for CCR4: |
Protein
Domains /
Families
for CCR4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCR4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51679ProtoNet protein and cluster: P51679 2 Blocks protein families: IPB000355 Chemokine receptor signature IPB002239 C-C chemokine receptor type 4 signature
UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for CCR4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CCR4_HUMAN, P51679Function: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor ismediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as achemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates.In the CNS, could mediate hippocampal-neuron survival Genatlas biochemistry entry for CCR4:chemokine CC,beta,receptor 4,with high affinity binding for basophil chemoattractant,G protein coupled receptorsuperfamily,specific receptor for thymus and activation-regulated chemokine
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004950 | chemokine receptor activity |
TAS | 7642634 | | GO:0016493 | C-C chemokine receptor activity |
IEA | -- |
CCR4 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CCR4:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ccr4):
CCR4 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Ccr4tm1Pwr for CCR4
Clone
Products: |  | EMD Millipore Clones for the Expression of CCR4 | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCR4 (NM_005508) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCR4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR4 |
|
Pathways & Interactions
for CCR4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Akt Signaling | | | 3 | Signaling by GPCR | | | 4 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | | | 5 | Chemokine Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CCR4
5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR4 (see all 8)
2  BioSystems Pathways for CCR4
5/8 
Reactome Pathways for CCR4 (see all 8)
2 
Kegg Pathways (Kegg details for CCR4):
CCR4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCR4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/60 Interacting proteins for CCR4 (P516792, 3 ENSP000003326594) via UniProtKB, MINT, STRING, and/or I2D (see all 60)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
CCR4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCR4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CCR4 for compounds About GeneDecksing
Compounds for CCR4 available from Tocris Bioscience About this table
1 HMDB Compound for CCR4 About this table
10/17 Novoseek chemical compound relationships for CCR4 gene (see all 17) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tarc |
96.8 |
153 |
9169480 (5), 15955100 (4), 17546636 (4), 15788694 (4) (see all 76) |
| rantes |
79.3 |
21 |
9169480 (2), 16211583 (2), 18691293 (2), 12270118 (2) (see all 16) |
| ccl3 |
73 |
2 |
11145678 (1), 14747532 (1) |
| larc |
58.4 |
2 |
9169480 (1), 9365118 (1) |
| teck |
54.5 |
1 |
15996192 (1) |
| [alcl] |
42.9 |
7 |
20217288 (2), 12181269 (2), 15289861 (1) |
| ccl4 |
41.7 |
3 |
11145678 (1), 14747532 (1), 15319172 (1) |
| calcium |
19.7 |
15 |
16815309 (2), 9169480 (2), 16614259 (2), 9743322 (1) (see all 11) |
| retinoid |
3.49 |
1 |
15118371 (1) |
| lipid |
0.847 |
1 |
14971049 (1) |
Search CenterWatch for drugs/clinical trials and news about CCR4
|
Transcripts
for CCR4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCR4 gene: NM_005508.4 Unigene Cluster for CCR4: Chemokine (C-C motif) receptor 4 Hs.184926 [show with all ESTs]Unigene Representative Sequence: BC0717511 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330953(uc003cfg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCR4 (NM_005508) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCR4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR4 |
Additional cDNA sequence: AK292674.1 BC069139.1 BC071751.1 BC074935.2 2 DOTS entries: DT.100731833 DT.40117006 11 AceView cDNA sequences: BC074935 BC069139 NM_005508 CN839223 CD640816 CD639869 BC071751 CN838882 CB269299 CB269413 X85740
GeneLoc Exon Structure
|
Expression
for CCR4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGTTCTA
About this image
See CCR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCR4
SOURCE GeneReport for Unigene cluster: Hs.184926
UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679Tissue specificity: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostlyCD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also inmacrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing thecutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells
SABiosciences Expression via Pathway-Focused PCR Arrays including CCR4 (see all 14):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR4 |
Orthologs
for CCR4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCR4 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for CCR4 (if available)
TreeFam Gene Tree for CCR4 (if available) |
Paralogs
for CCR4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCR4 gene
- CCR62 CCR52 CXCR62 CXCR32 XCR12 CCR92 CCBP22 CCRL22
- CCR72 CX3CR12 CCR82 CXCR22 CCRL12 CCR12 CXCR12 CCR22
- CXCR52 CCR102 CCR32 CXCR42
18/46 SIMAP similar genes for CCR4 using alignment to 2 protein entries: CCR4_HUMAN (see all proteins)
(see all similar genes):CCR-5 CCR5 CCR1 CCR2 CCR3 CCR8
CCR6 CCBP2 CXCR2 IL8RB CCR7 CX3CR1
CXCR6 CXCR1 XCR1 AGTR1 CCR9 LPAR4
CCR4 for paralogs About GeneDecksing
|
Genomic Variants
for CCR4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCR4 (32993066 - 32997841 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCR4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR4 |
|
Disorders
/ Diseases
for CCR4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCR4 for disorders About GeneDecksing
OMIM gene information: 604836
OMIM disorders: --
20/82  diseases for CCR4 (see all 82): About MalaCardslymphomatoid papulosis b-cell non-hodgkin lymphoma pityriasis lichenoides anaplastic large cell lymphoma
diffuse large b-cell lymphoma human t-cell leukemia virus type 1 hematopoiesis non-hodgkin lymphoma
allergic bronchopulmonary aspergillosis mycosis fungoides graft versus host disease nonspecific interstitial pneumonia
b-cell lymphomas allergic contact dermatitis contact dermatitis intermediate uveitis
allergic rhinitis lupus erythematosus bullous pemphigoid dermatitis
10/50 Novoseek disease relationships for CCR4 gene (see all 50) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mycosis fungoides |
65.2 |
11 |
14708605 (2), 12393570 (1), 16713487 (1), 10887135 (1) (see all 9) |
| sezary syndrome |
64 |
7 |
17546636 (2), 12393570 (1), 15727636 (1), 19239991 (1) (see all 5) |
| lymphoma t-cell peripheral |
63.6 |
6 |
15328188 (2), 11979374 (1), 20217288 (1), 12645345 (1) (see all 5) |
| dermatitis atopic |
61.6 |
36 |
11511293 (7), 15202833 (4), 10998136 (2), 12190665 (2) (see all 14) |
| lymphoma t-cell cutaneous |
58.5 |
4 |
19242508 (1), 15727636 (1), 19239991 (1) |
| leukemia t-cell |
55.9 |
4 |
11861261 (2), 15026353 (1), 18178833 (1) |
| inflammation |
51.5 |
34 |
19208087 (2), 16918452 (2), 12009564 (2), 11786428 (1) (see all 22) |
| lymphomatoid papulosis |
51.2 |
3 |
16931956 (1), 12181269 (1) |
| lymphoma t-cell |
51.1 |
9 |
12485447 (4), 18842429 (1), 15328188 (1), 16931956 (1) |
| anaplastic large cell lymphoma |
50.9 |
3 |
15328188 (1), 20217288 (1), 12181269 (1) |
Genetic Association Database (GAD): CCR4
Human Genome Epidemiology (HuGE) Navigator: CCR4 (12 documents)
Export disorders for CCR4 gene to outside databases
|
Publications
for CCR4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCR4 gene, integrated from 9 sources (see all 444):
(articles sorted by number of sources associating them with CCR4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- New variations of human CC-chemokine receptors CCR3 and CCR4. (PubMed id 11196669)1, 2, 4, 9 Kato H.... Tokunaga K. (1999)
- Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. (PubMed id 7642634)1, 2, 3 Power C.A.... Wells T.N.C. (1995)
- Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. (PubMed id 10754297)1, 2, 9 Inngjerdingen M.... Maghazachi A.A. (2000)
- The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. (PubMed id 9169480)1, 2, 9 Imai T.... Yoshie O. (1997)
- Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PubMed id 9430724)1, 2, 9 Imai T.... Gray P.W. (1998)
- Lack of association of CCR4 single nucleotide polymorphism with atopic dermatitis in Japanese patients. (PubMed id 15202833)1, 4, 9 Tsunemi Y....Tamaki K. (2004)
- The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. (PubMed id 10466728)1, 2, 9 Campbell J.J.... Butcher E.C. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3. (PubMed id 8884276)1, 3 Samson M....Parmentier M. (1996)
- Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. (PubMed id 11861261)1, 9 Yoshie O....Yamada Y. (2002)
|
External Searches for CCR4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCR4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCR4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCR4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCR4 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/CC_chemokine_receptors |
|
| | |
About This Section
| Patent Information for CCR4 gene:
Search GeneIP for patents involving CCR4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CCR4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for CCR4 | | OriGene shRNA RFP for CCR4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCR4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR4 | | | OriGene Protein Over-expression Lysate for CCR4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCR4 | | OriGene 3'-UTR Clone for CCR4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCR4 | | OriGene Custom Protein Services for CCR4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCR4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR4 |
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| | | | Tocris compounds for CCR4 |
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 | | | CCR4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR4 |
|  |  |  |  | | | | ThermoFisher Antibodies for CCR4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR4 |
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