Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCR4 Gene

Aliases for CCR4 Gene

  • Chemokine (C-C Motif) Receptor 4 2 3
  • CMKBR4 3 4 6
  • C-C CKR-4 3 4
  • CC-CKR-4 3 4
  • CCR-4 3 4
  • CKR4 3 6
  • K5-5 3 4
  • C-C Chemokine Receptor Type 4 3
  • Chemokine (C-C) Receptor 4 3
  • CD194 Antigen 4
  • HGCN:14099 3
  • ChemR13 3
  • CD194 3

External Ids for CCR4 Gene

Summaries for CCR4 Gene

Entrez Gene Summary for CCR4 Gene

  • The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR4 Gene

CCR4 (Chemokine (C-C Motif) Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include pityriasis lichenoides and alk-negative anaplastic large cell lymphoma. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include chemokine receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR4 Gene

  • High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Tocris Summary for CCR4 Gene

  • Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorised into four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are classified according to the class of chemokines that they bind. The major function of chemokines is to regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR4 Gene

Genomics for CCR4 Gene

Genomic Location for CCR4 Gene

Start:
32,951,574 bp from pter
End:
32,956,349 bp from pter
Size:
4,776 bases
Orientation:
Plus strand

Genomic View for CCR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR4 Gene

Regulatory Elements for CCR4 Gene

Proteins for CCR4 Gene

  • Protein details for CCR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51679-CCR4_HUMAN
    Recommended name:
    C-C chemokine receptor type 4
    Protein Accession:
    P51679
    Secondary Accessions:
    • Q9ULY6
    • Q9ULY7

    Protein attributes for CCR4 Gene

    Size:
    360 amino acids
    Molecular mass:
    41403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR4 Gene

Proteomics data for CCR4 Gene at MOPED

Post-translational modifications for CCR4 Gene

  • In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.

Other Protein References for CCR4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCR4 Gene

Domains for CCR4 Gene

Gene Families for CCR4 Gene

HGNC:
  • CD :CD molecules
  • CCR :GPCR / Class A : Chemokine receptors : C-C motif
IUPHAR :

Suggested Antigen Peptide Sequences for CCR4 Gene

Graphical View of Domain Structure for InterPro Entry

P51679

UniProtKB/Swiss-Prot:

CCR4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P51679
genes like me logo Genes that share domains with CCR4: view

Function for CCR4 Gene

Molecular function for CCR4 Gene

GENATLAS Biochemistry: chemokine CC,beta,receptor 4,with high affinity binding for basophil chemoattractant,G protein coupled receptor superfamily,specific receptor for thymus and activation-regulated chemokine
UniProtKB/Swiss-Prot Function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Gene Ontology (GO) - Molecular Function for CCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 7642634
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR4: view

Phenotypes for CCR4 Gene

genes like me logo Genes that share phenotypes with CCR4: view

Animal Models for CCR4 Gene

MGI Knock Outs for CCR4:

miRNA for CCR4 Gene

miRTarBase miRNAs that target CCR4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCR4 Gene

Localization for CCR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR4 Gene COMPARTMENTS Subcellular localization image for CCR4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7642634
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CCR4: view

Pathways for CCR4 Gene

genes like me logo Genes that share pathways with CCR4: view

Gene Ontology (GO) - Biological Process for CCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0002507 tolerance induction IEA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCR4: view

Compounds for CCR4 Gene

(5) Tocris Compounds for CCR4 Gene

Compound Action Cas Number
Maraviroc Selective CCR5 antagonist [376348-65-1]
RS 504393 Highly selective CCR2 chemokine receptor antagonist [300816-15-3]
SB 225002 Potent and selective CXCR2 antagonist [182498-32-4]
SB 265610 Potent CXCR2 antagonist [211096-49-0]
TC 14012 CXCR4 antagonist; CXCR7 agonist [368874-34-4]

(1) HMDB Compounds for CCR4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(5) IUPHAR Ligand for CCR4 Gene

Ligand Type Action Affinity Pubmed IDs
CCL22 Agonist Full agonist 9.2
CCL17 Agonist Agonist
[125I]CCL17 Agonist Full agonist
vMIP-III Agonist Agonist
[125I]CCL27 Agonist Agonist

(17) Novoseek inferred chemical compound relationships for CCR4 Gene

Compound -log(P) Hits PubMed IDs
tarc 96.8 122
rantes 79.3 21
ccl3 73 2
larc 58.4 2
teck 54.5 1
genes like me logo Genes that share compounds with CCR4: view

Transcripts for CCR4 Gene

mRNA/cDNA for CCR4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCR4 Gene

Chemokine (C-C motif) receptor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCR4 Gene

No ASD Table

Relevant External Links for CCR4 Gene

GeneLoc Exon Structure for
CCR4
ECgene alternative splicing isoforms for
CCR4

Expression for CCR4 Gene

mRNA expression in normal human tissues for CCR4 Gene

mRNA differential expression in normal tissues according to GTEx for CCR4 Gene

This gene is overexpressed in Whole Blood (15.8), Spleen (4.7), and Lung (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCR4 Gene

SOURCE GeneReport for Unigene cluster for CCR4 Gene Hs.184926

mRNA Expression by UniProt/SwissProt for CCR4 Gene

P51679-CCR4_HUMAN
Tissue specificity: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
genes like me logo Genes that share expressions with CCR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCR4 Gene

Orthologs for CCR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR4 35
  • 99.91 (n)
  • 100 (a)
CCR4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCR4 35
  • 87.09 (n)
  • 89.97 (a)
CCR4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR4 35
  • 87.59 (n)
  • 91.94 (a)
CCR4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr4 35
  • 82.96 (n)
  • 86.67 (a)
Ccr4 16
Ccr4 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCR4 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCR4 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr4 35
  • 81.48 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves CCR4 35
  • 63.29 (n)
  • 59.54 (a)
CCR4 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCR4 36
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX511173.1 36
  • 40 (a)
ManyToMany
BX537113.1 36
  • 40 (a)
ManyToMany
BX537113.1 36
  • 40 (a)
ManyToMany
CABZ01093075.1 36
  • 34 (a)
ManyToMany
ccr8.1 36
  • 37 (a)
ManyToMany
ccr8.1 36
  • 37 (a)
ManyToMany
LOC100329837 35
  • 52.35 (n)
  • 43.93 (a)
Species with no ortholog for CCR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR4 Gene

ENSEMBL:
Gene Tree for CCR4 (if available)
TreeFam:
Gene Tree for CCR4 (if available)

Paralogs for CCR4 Gene

genes like me logo Genes that share paralogs with CCR4: view

Variants for CCR4 Gene

Sequence variations from dbSNP and Humsavar for CCR4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2228428 -- 32,954,436(+) ATTTA(C/T)TCTGC reference, synonymous-codon
rs6550178 -- 32,952,000(+) CACAC(A/G)CAAGG intron-variant
rs6770096 -- 32,955,017(+) ATTAG(C/T)GAAGT downstream-variant-500B
rs7632357 -- 32,950,711(+) CTGAC(G/T)CAAAA upstream-variant-2KB
rs9872264 -- 32,953,318(+) GCAAT(A/G)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCR4 Gene

Variant ID Type Subtype PubMed ID
nsv508909 CNV Insertion 20534489
nsv876678 CNV Loss 21882294

Relevant External Links for CCR4 Gene

HapMap Linkage Disequilibrium report
CCR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR4 Gene

Disorders for CCR4 Gene

(50) Novoseek inferred disease relationships for CCR4 Gene

Disease -log(P) Hits PubMed IDs
mycosis fungoides 65.2 10
sezary syndrome 64 6
lymphoma t-cell peripheral 63.6 6
dermatitis atopic 61.6 28
lymphoma t-cell cutaneous 58.5 3

Relevant External Links for CCR4

Genetic Association Database (GAD)
CCR4
Human Genome Epidemiology (HuGE) Navigator
CCR4
genes like me logo Genes that share disorders with CCR4: view

No data available for UniProtKB/Swiss-Prot for CCR4 Gene

Publications for CCR4 Gene

  1. New variations of human CC-chemokine receptors CCR3 and CCR4. (PMID: 11196669) Kato H. … Tokunaga K. (Genes Immun. 1999) 3 4 23 48
  2. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. (PMID: 9169480) Imai T. … Yoshie O. (J. Biol. Chem. 1997) 3 4 23
  3. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. (PMID: 10466728) Campbell J.J. … Butcher E.C. (Nature 1999) 3 4 23
  4. Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. (PMID: 10754297) Inngjerdingen M. … Maghazachi A.A. (J. Immunol. 2000) 3 4 23
  5. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PMID: 9430724) Imai T. … Gray P.W. (J. Biol. Chem. 1998) 3 4 23

Products for CCR4 Gene

Sources for CCR4 Gene

Back to Top

Content