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Aliases for CCR4 Gene

Aliases for CCR4 Gene

  • C-C Motif Chemokine Receptor 4 2 3 5
  • Chemokine (C-C Motif) Receptor 4 2 3
  • C-C CKR-4 3 4
  • CC-CKR-4 3 4
  • CMKBR4 3 4
  • CCR-4 3 4
  • K5-5 3 4
  • C-C Chemokine Receptor Type 4 3
  • Chemokine (C-C) Receptor 4 3
  • CD194 Antigen 4
  • HGCN:14099 3
  • ChemR13 3
  • CD194 3
  • CKR4 3

External Ids for CCR4 Gene

Previous GeneCards Identifiers for CCR4 Gene

  • GC03U990019
  • GC03P032841
  • GC03P032966
  • GC03P032964

Summaries for CCR4 Gene

Entrez Gene Summary for CCR4 Gene

  • The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR4 Gene

CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include Cutaneous T Cell Lymphoma and Mycosis Fungoides. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot for CCR4 Gene

  • High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Tocris Summary for CCR4 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Gene Wiki entry for CCR4 Gene

Additional gene information for CCR4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR4 Gene

Genomics for CCR4 Gene

GeneHancer (GH) Regulatory Elements for CCR4 Gene

Promoters and enhancers for CCR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I032951 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 +0.7 696 2.2 BCOR TEAD4 TAL1 TCF12 NCOR1 SCRT2 CBFA2T2 ETV6 TRIM24 RUNX3 CCR4 LOC105377022
GH03I033047 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 21.9 +96.6 96554 1.2 IKZF1 EBF1 DPF2 IKZF2 IRF4 RUNX3 SPI1 CCR4 SEC13P1 SUMO2P10 GLB1
GH03I033716 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.4 +766.3 766304 2.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B CBX5 CLASP2 CCR4 FBXL2 UBP1 GC03M033664 GC03M033663
GH03I033044 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 18.5 +93.2 93187 0.3 ATF2 CCR4 GLB1 TMPPE CRTAP SEC13P1 SUMO2P10
GH03I033019 Enhancer 0.4 FANTOM5 22 +67.9 67896 0.3 FOXA2 FOXA1 CCR4 SUGT1P2 CNOT10-AS1 CNOT10 TMPPE GLB1 CRTAP SEC13P1 LOC105377022
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCR4 gene promoter:

Genomic Locations for CCR4 Gene

Genomic Locations for CCR4 Gene
chr3:32,951,574-32,956,349
(GRCh38/hg38)
Size:
4,776 bases
Orientation:
Plus strand
chr3:32,993,066-32,997,841
(GRCh37/hg19)

Genomic View for CCR4 Gene

Genes around CCR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR4 Gene

Proteins for CCR4 Gene

  • Protein details for CCR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51679-CCR4_HUMAN
    Recommended name:
    C-C chemokine receptor type 4
    Protein Accession:
    P51679
    Secondary Accessions:
    • Q9ULY6
    • Q9ULY7

    Protein attributes for CCR4 Gene

    Size:
    360 amino acids
    Molecular mass:
    41403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR4 Gene

Post-translational modifications for CCR4 Gene

  • In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
  • Glycosylation at Asn183 and posLast=194194

Other Protein References for CCR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCR4 Gene

Domains & Families for CCR4 Gene

Gene Families for CCR4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CCR4 Gene

Graphical View of Domain Structure for InterPro Entry

P51679

UniProtKB/Swiss-Prot:

CCR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR4: view

Function for CCR4 Gene

Molecular function for CCR4 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 4,with high affinity binding for basophil chemoattractant,G protein coupled receptor superfamily,specific receptor for thymus and activation-regulated chemokine
UniProtKB/Swiss-Prot Function:
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Phenotypes From GWAS Catalog for CCR4 Gene

Gene Ontology (GO) - Molecular Function for CCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 7642634
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR4: view
genes like me logo Genes that share phenotypes with CCR4: view

Animal Models for CCR4 Gene

MGI Knock Outs for CCR4:

Clone Products

  • Addgene plasmids for CCR4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCR4 Gene

Localization for CCR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR4 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7642634
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCR4 Gene

Pathways & Interactions for CCR4 Gene

genes like me logo Genes that share pathways with CCR4: view

Gene Ontology (GO) - Biological Process for CCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0002507 tolerance induction IEA --
GO:0006935 chemotaxis TAS,IEA --
GO:0006954 inflammatory response IEA,TAS --
GO:0006955 immune response IEA,TAS --
genes like me logo Genes that share ontologies with CCR4: view

No data available for SIGNOR curated interactions for CCR4 Gene

Drugs & Compounds for CCR4 Gene

(24) Drugs for CCR4 Gene - From: ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Procaine Approved, Investigational, Vet_approved Pharma Channel blocker 60
Plerixafor Approved Pharma Agonist, antagonist 0
mogamulizumab Investigational Pharma antibody Therapeutic Antibodies 0
CCL17 Pharma Full agonist, Agonist 0

(12) Additional Compounds for CCR4 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL17
Full agonist, Agonist
[<sup>125</sup>I]CCL27
Agonist

(5) Tocris Compounds for CCR4 Gene

Compound Action Cas Number
DAPTA Chemokine receptor 5 (CCR5) antagonist 106362-34-9
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3
ZK 756326 Selective, non-peptide CCR8 agonist 874911-96-3

(1) ApexBio Compounds for CCR4 Gene

Compound Action Cas Number
C 021 dihydrochloride Potent CCR4 antagonist 864289-85-0
genes like me logo Genes that share compounds with CCR4: view

Drug Products

Transcripts for CCR4 Gene

mRNA/cDNA for CCR4 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCR4 Gene

Chemokine (C-C motif) receptor 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCR4

Alternative Splicing Database (ASD) splice patterns (SP) for CCR4 Gene

No ASD Table

Relevant External Links for CCR4 Gene

GeneLoc Exon Structure for
CCR4
ECgene alternative splicing isoforms for
CCR4

Expression for CCR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCR4 Gene

mRNA differential expression in normal tissues according to GTEx for CCR4 Gene

This gene is overexpressed in Whole Blood (x15.8), Spleen (x4.7), and Lung (x4.6).

Protein differential expression in normal tissues from HIPED for CCR4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR4 Gene



Protein tissue co-expression partners for CCR4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCR4 Gene:

CCR4

SOURCE GeneReport for Unigene cluster for CCR4 Gene:

Hs.184926

mRNA Expression by UniProt/SwissProt for CCR4 Gene:

P51679-CCR4_HUMAN
Tissue specificity: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.

Evidence on tissue expression from TISSUES for CCR4 Gene

  • Blood(4.3)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with CCR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR4 Gene

Orthologs for CCR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR4 33 34
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia CCR4 33 34
  • 87.59 (n)
cow
(Bos Taurus)
Mammalia CCR4 33 34
  • 87.09 (n)
mouse
(Mus musculus)
Mammalia Ccr4 33 16 34
  • 82.96 (n)
rat
(Rattus norvegicus)
Mammalia Ccr4 33
  • 81.48 (n)
oppossum
(Monodelphis domestica)
Mammalia CCR4 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCR4 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCR4 33 34
  • 63.29 (n)
lizard
(Anolis carolinensis)
Reptilia CCR4 34
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100329837 33
  • 52.35 (n)
BX511173.1 34
  • 40 (a)
ManyToMany
BX537113.1 34 34
  • 40 (a)
ManyToMany
ccr8.1 34 34
  • 37 (a)
ManyToMany
CABZ01093075.1 34
  • 34 (a)
ManyToMany
Species where no ortholog for CCR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR4 Gene

ENSEMBL:
Gene Tree for CCR4 (if available)
TreeFam:
Gene Tree for CCR4 (if available)

Paralogs for CCR4 Gene

Variants for CCR4 Gene

Sequence variations from dbSNP and Humsavar for CCR4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000863052 -- 32,952,484(+) C/T intron_variant
rs1000927514 -- 32,952,981(+) A/G intron_variant
rs1001107718 -- 32,952,712(+) G/C intron_variant
rs1001455593 -- 32,951,758(+) C/T intron_variant
rs1001599783 -- 32,950,672(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCR4 Gene

Variant ID Type Subtype PubMed ID
nsv1003285 CNV gain 25217958
nsv508909 CNV insertion 20534489
nsv998302 CNV gain 25217958

Variation tolerance for CCR4 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR4 Gene

Disorders for CCR4 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CCR4 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CCR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCR4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR4 Gene

Publications for CCR4 Gene

  1. New variations of human CC-chemokine receptors CCR3 and CCR4. (PMID: 11196669) Kato H … Tokunaga K (Genes and immunity 1999) 3 4 22 44 58
  2. Association screen for atopic dermatitis candidate gene regions using microsatellite markers in pooled DNA samples. (PMID: 17117949) Hoffjan S … Epplen JT (International journal of immunogenetics 2006) 3 22 44 58
  3. Lack of association of CCR4 single nucleotide polymorphism with atopic dermatitis in Japanese patients. (PMID: 15202833) Tsunemi Y … Tamaki K (Acta dermato-venereologica 2004) 3 22 44 58
  4. Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. (PMID: 10754297) Inngjerdingen M … Maghazachi AA (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 58
  5. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. (PMID: 10466728) Campbell JJ … Butcher EC (Nature 1999) 3 4 22 58

Products for CCR4 Gene

Sources for CCR4 Gene

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