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CCR4 Gene

protein-coding   GIFtS: 65
GCID: GC03P032968

Chemokine (C-C Motif) Receptor 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Receptor 41 2     CD1942
CMKBR42 3 5     ChemR132
CC-CKR-42 3     HGCN:140992
CCR-42 3     C-C Chemokine Receptor Type 42
K5-52 3     Chemokine (C-C) Receptor 42
C-C CKR-42 3     CD194 Antigen3
CKR42 5     

External Ids:    HGNC: 16051   Entrez Gene: 12332   Ensembl: ENSG000001838137   OMIM: 6048365   UniProtKB: P516793   

Export aliases for CCR4 gene to outside databases

Previous GC identifers: GC03U990019 GC03P032841 GC03P032966 GC03P032964


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCR4 Gene:
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC
chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related
molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental
roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the
central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CCR4 Gene:
CCR4 (chemokine (C-C motif) receptor 4) is a protein-coding gene. Diseases associated with CCR4 include pityriasis lichenoides, and primary cutaneous anaplastic large cell lymphoma. GO annotations related to this gene include C-C chemokine receptor activity and chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679
Function: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this
receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can
function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some
primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival

summary for CCR4 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCR4 gene promoter:
         AhR   STAT1   Pax-2   Pax-2a   POU6F1 (c2)   XBP-1   c-Ets-1   PPAR-alpha   Pax-2b   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCR4 promoter sequence
   Search Chromatin IP Primers for CCR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p24-p21.3

CCR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P032968:  view genomic region     (about GC identifiers)

Start:
32,993,066 bp from pter      End:
32,997,841 bp from pter
Size:
4,776 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679 (See protein sequence)
Recommended Name: C-C chemokine receptor type 4  
Size: 360 amino acids; 41403 Da
Secondary accessions: Q9ULY6 Q9ULY7

Explore the universe of human proteins at neXtProt for CCR4: NX_P51679

Explore proteomics data for CCR4 at MOPED

Post-translational modifications: 

  • In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by
    beta-adrenergic receptor kinases 1 and 21
  • Modification sites at neXtProt

  • See CCR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005499.1  
    ENSEMBL proteins: 
     ENSP00000332659  
    Reactome Protein details: P51679

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR4
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002239 Chemokine_CCR4
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P51679

    ProtoNet protein and cluster: P51679

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB002239 C-C chemokine receptor type 4 signature


    UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CCR4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR4_HUMAN, P51679
    Function: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this
    receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can
    function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some
    primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival

         Genatlas biochemistry entry for CCR4:
    chemokine CC,beta,receptor 4,with high affinity binding for basophil chemoattractant,G protein coupled receptor
    superfamily,specific receptor for thymus and activation-regulated chemokine

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS7642634
    GO:0016493C-C chemokine receptor activity IEA--
         
    CCR4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCR4:
     Elongated cells 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccr4):
     hematopoietic system  immune system  respiratory system 

    CCR4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccr4tm1Pwr for CCR4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR4

    miRNA
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    hsa-mir-335-5p (MIRT018019)

    Block miRNA regulation of human, mouse, rat CCR4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCR4
    SwitchGear 3'UTR luciferase reporter plasmidCCR4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCR4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CCR4 (NM_005508)
    Sino Biological Human cDNA Clone for CCR4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR4

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCR4_HUMAN, P51679: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    cytosol1
    extracellular1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7642634
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane ----
    GO:0043025neuronal cell body IEA--

    CCR4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCR4 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    5Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCR4
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR4 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 BioSystems Pathways for CCR4
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for CCR4
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for CCR4):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Viral carcinogenesis


    CCR4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR4 (see all 14): 
              HIV Host Response in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCR4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCR4 (P516792, 3 ENSP000003326594) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL22O006263, ENSP000002192354I2D: score=2 STRING: ENSP00000219235
    CCL5P135013, ENSP000002932724I2D: score=2 STRING: ENSP00000293272
    CCL17Q925833, ENSP000002192444I2D: score=2 STRING: ENSP00000219244
    ADRBK1P250983, ENSP000003122624I2D: score=2 STRING: ENSP00000312262
    ADRBK2P356263, ENSP000003175784I2D: score=2 STRING: ENSP00000317578
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0002507tolerance induction IEA--
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--

    CCR4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CCR4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    1 HMDB Compound for CCR4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 IUPHAR Ligands for CCR4 (CCR4)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCL22
    AgonistFull agonist9.29430724
    CCL17
    AgonistFull agonist8.79430724
    [125I]CCL17
    AgonistFull agonist8.7--
    vMIP-III
    AgonistAgonist8.7--
    [125I]CCL27
    AgonistAgonist8.7--

    Selected Novoseek inferred chemical compound relationships for CCR4 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 96.8 153 9169480 (5), 15955100 (4), 17546636 (4), 15788694 (4) (see all 76)
    rantes 79.3 21 9169480 (2), 16211583 (2), 18691293 (2), 12270118 (2) (see all 16)
    ccl3 73 2 11145678 (1), 14747532 (1)
    larc 58.4 2 9169480 (1), 9365118 (1)
    teck 54.5 1 15996192 (1)
    [alcl] 42.9 7 20217288 (2), 12181269 (2), 15289861 (1)
    ccl4 41.7 3 11145678 (1), 14747532 (1), 15319172 (1)
    calcium 19.7 15 16815309 (2), 9169480 (2), 16614259 (2), 9743322 (1) (see all 11)
    retinoid 3.49 1 15118371 (1)
    lipid 0.847 1 14971049 (1)



    CCR4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCR4 gene: 
    NM_005508.4  

    Unigene Cluster for CCR4:

    Chemokine (C-C motif) receptor 4
    Hs.184926  [show with all ESTs]
    Unigene Representative Sequence: BC071751
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330953(uc003cfg.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CCR4

    Additional mRNA sequence: 

    AK292674.1 BC069139.1 BC071751.1 BC074935.2 

    2 DOTS entries:

    DT.100731833  DT.40117006 

    11 AceView cDNA sequences:

    BC074935 BC069139 NM_005508 CD640816 CD639869 CN839223 CN838882 BC071751 
    CB269413 CB269299 X85740 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTTCTA
    CCR4 Expression
    About this image

    CCR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCR4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.184926

    UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679
    Tissue specificity: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells,
    mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected
    also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones
    expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery
    endothelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR4 (see all 14): 
              HIV Host Response in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CCR4
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    QuantiFast Probe-based Assays in human, mouse, rat CCR4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCR4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr41 , 5 chemokine (C-C motif) receptor 41, 5 82.96(n)1
    86.67(a)1
      9 (64.49 cM)5
    127731  NM_009916.21  NP_034046.21 
     1144903165 
    chicken
    (Gallus gallus)
    Aves CCR41 chemokine (C-C motif) receptor 4 63.29(n)
    59.54(a)
      428457  XM_004939483.1  XP_004939540.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCR46
    chemokine (C-C motif) receptor 4
    58(a)
    1 ↔ 1
    GL343324.1(573160-574242)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003298371 c-C chemokine receptor type 4-like 52.35(n)
    43.93(a)
      100329837  XM_005173464.1  XP_005173521.1 


    ENSEMBL Gene Tree for CCR4 (if available)
    TreeFam Gene Tree for CCR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CCR4 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CCR4 using alignment to 2 protein entries:     CCR4_HUMAN (see all proteins) (see all similar genes):
    CCR-5    CCR2    CCR5    CCR1    CCR3    CCR8
    ACKR2    CCR6    CCBP2    CXCR2    IL8RB    CCR7
    CX3CR1    CXCR6    CXCR1    XCR1    AGTR1    CCR9

    CCR4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCR4 (see all 158)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847579051,2
    --32991141(+) AGCTCA/GTTGCT 1 -- us2k10--------
    rs1508371301,2
    --32991164(+) TTCTCA/TACCTC 1 -- us2k10--------
    rs1392494081,2
    --32991207(+) TTGCTC/GTGGTG 1 -- us2k10--------
    rs1901333991,2
    --32991229(+) GCATTA/GTAGGA 1 -- us2k10--------
    rs1428888581,2
    C--32991249(+) CATTCC/TTGGAC 1 -- us2k10--------
    rs1144341691,2
    C,F--32991255(+) TGGACT/ACTACC 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1817544791,2
    --32991256(+) GGACTC/GTACCC 1 -- us2k10--------
    rs778531521,2
    C--32991286(+) CTGGGC/TGCGGT 1 -- us2k10--------
    rs111295381,2
    C,F,A,H--32991289(+) GGTGCG/AGTGGC 1 -- us2k15Minor allele frequency- A:0.14NA WA CSA 128
    rs1400619891,2
    C--32991300(+) TCATGC/TCTATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCR4 (32993066 - 32997841 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCR4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508909CNV Insertion20534489
    nsv876678CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCR4
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604836    OMIM disorders: --

    Selected diseases for CCR4 (see all 85):    
    About MalaCards
    pityriasis lichenoides    primary cutaneous anaplastic large cell lymphoma    alk-negative anaplastic large cell lymphoma    atopic keratoconjunctivitis
    intermediate uveitis    granulomatosis with polyangiitis    adult t-cell leukemia    pustulosis palmaris et plantaris
    anaplastic large cell lymphoma    peripheral t-cell lymphoma    eosinophilic pneumonia    skin melanoma
    mycosis fungoides    lymphomatoid papulosis    allergic bronchopulmonary aspergillosis    dermatitis
    aspergillosis    pulmonary fibrosis    cutaneous lupus erythematosus    nonspecific interstitial pneumonia


    CCR4 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CCR4 gene (see all 50)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mycosis fungoides 65.2 11 14708605 (2), 12393570 (1), 16713487 (1), 10887135 (1) (see all 9)
    sezary syndrome 64 7 17546636 (2), 12393570 (1), 15727636 (1), 19239991 (1) (see all 5)
    lymphoma t-cell peripheral 63.6 6 15328188 (2), 11979374 (1), 20217288 (1), 12645345 (1) (see all 5)
    dermatitis atopic 61.6 36 11511293 (7), 15202833 (4), 10998136 (2), 12190665 (2) (see all 14)
    lymphoma t-cell cutaneous 58.5 4 19242508 (1), 15727636 (1), 19239991 (1)
    leukemia t-cell 55.9 4 11861261 (2), 15026353 (1), 18178833 (1)
    inflammation 51.5 34 19208087 (2), 16918452 (2), 12009564 (2), 11786428 (1) (see all 22)
    lymphomatoid papulosis 51.2 3 16931956 (1), 12181269 (1)
    lymphoma t-cell 51.1 9 12485447 (4), 18842429 (1), 15328188 (1), 16931956 (1)
    anaplastic large cell lymphoma 50.9 3 15328188 (1), 20217288 (1), 12181269 (1)

    Genetic Association Database (GAD): CCR4
    Human Genome Epidemiology (HuGE) Navigator: CCR4 (12 documents)

    Export disorders for CCR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCR4 gene, integrated from 10 sources (see all 450):
    (articles sorted by number of sources associating them with CCR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New variations of human CC-chemokine receptors CCR3 and CCR4. (PubMed id 11196669)1, 2, 4, 9 Kato H.... Tokunaga K. (Genes Immun. 1999)
    2. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. (PubMed id 7642634)1, 2, 3 Power C.A.... Wells T.N.C. (J. Biol. Chem. 1995)
    3. Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. (PubMed id 10754297)1, 2, 9 Inngjerdingen M.... Maghazachi A.A. (J. Immunol. 2000)
    4. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. (PubMed id 9169480)1, 2, 9 Imai T.... Yoshie O. (J. Biol. Chem. 1997)
    5. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PubMed id 9430724)1, 2, 9 Imai T.... Gray P.W. (J. Biol. Chem. 1998)
    6. Lack of association of CCR4 single nucleotide polymorphism with atopic dermatitis in Japanese patients. (PubMed id 15202833)1, 4, 9 Tsunemi Y....Tamaki K. (Acta Derm. Venereol. 2004)
    7. Association screen for atopic dermatitis candidate gene regions using microsatellite markers in pooled DNA samples. (PubMed id 17117949)1, 4, 9 Hoffjan S....Epplen J.T. (Int. J. Immunogenet. 2006)
    8. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. (PubMed id 10466728)1, 2, 9 Campbell J.J.... Butcher E.C. (Nature 1999)
    9. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    10. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1233 HGNC: 1605 AceView: CCR4 Ensembl:ENSG00000183813 euGenes: HUgn1233
    ECgene: CCR4 Kegg: 1233 H-InvDB: CCR4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCR4 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCR4 gene:
    Search GeneIP for patents involving CCR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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