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CCR4 Gene

protein-coding GIFtS: 65

GC03P032968

chemokine (C-C motif) receptor 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CC-CKR-4 ^¹, ², ³
CCR-4 ^³
CD194 ^¹, ²
CKR4 ^¹, ², ⁵
CMKBR4 ^¹, ², ³, ⁵
ChemR13 ^¹, ²
HGCN:14099 ^²
K5-5 ^², ³
MGC88293 ^²
k5-5 ^¹

Descriptions
C-C CKR-4 ^³
CD194 antigen ^³
chemokine (C-C motif) receptor 4 ^²
chemokine (C-C) receptor 4 ^²

External Ids
HGNC: 1605¹
Entrez Gene: 1233²
UniProtKB: P51679³
Ensembl: ENSG00000183813⁷

Search outside databases for aliases for CCR4 gene

Previous GC identifers: GC03U990019 GC03P032841 GC03P032966 GC03P032964

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CCR4:

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a

receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small

polypeptide, structurally related molecules that regulate cell trafficking of various types of

leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and

function of the immune system, and they have effects on cells of the central nervous system as

well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq]

UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679

Function: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity

of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second

messenger system. Can function as a chemoattractant homing receptor on circulating memory

lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate

hippocampal-neuron survival

Gene Wiki entry for CCR4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CCR4 gene

Entrez Gene cytogenetic band: 3p24 Ensembl cytogenetic band: 3p22.3 HGNC cytogenetic band: 3p24-p21.3

CCR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P032968: (about GC identifiers)

Start:	32,968,070 bp from pter
End:	32,971,407 bp from pter
Size:	3,338 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679 (See protein sequence)

Recommended Name: C-C chemokine receptor type 4

Size: 360 amino acids; 41403 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q9ULY6 Q9ULY7

Post-translational modifications:

In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues,

most probably by beta-adrenergic receptor kinases 1 and 2¹

REFSEQ proteins: NP_005499.1

ENSEMBL proteins:

ENSP00000332659

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CCR4 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CCR4)
	Human Recombinant Proteins from Abnova (CCR4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	7642634
GO:0005887	integral to plasma membrane	TAS	7642634

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Antibodies for CCR4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for CCR4
	Antibodies from Abcam (CCR4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CCR4)
	Novus Biologicals Antibodies for CCR4

Assays for CCR4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P51679

ProtoNet protein and cluster: P51679

2 Blocks protein families:

IPB000355 Chemokine receptor signature

IPB002239 C-C chemokine receptor type 4 signature

UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCR4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCR4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005508

Applied Biosystems Silencer® siRNAs for CCR4

Sigma-Aldrich siRNA and siRNA Panels for CCR4

Sigma-Aldrich shRNA Panels and shRNA for CCR4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CCR4
		Millipore Clones for the Expression of CCR4

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005508
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005508
untagged cDNA clone in CMV expression vector: NM_005508

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005508

UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679

Function: High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity

of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second

messenger system. Can function as a chemoattractant homing receptor on circulating memory

lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate

hippocampal-neuron survival

Genatlas biochemistry entry for CCR4:

chemokine CC,beta,receptor 4,with high affinity binding for basophil chemoattractant,G protein

coupled receptor superfamily,specific receptor for thymus and activation-regulated chemokine

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccr4):

hematopoietic system

immune system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0016493	C-C chemokine receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CCR4

5/45 Interacting proteins for CCR4 (ENSP00000332659³ P51679²) via UniProtKB, MINT, and/or STRING (see all 45 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCL17	ENSP00000219244³	STRING (score=.996)
CCL5	ENSP00000293272³	STRING (score=.995)
CCL22	ENSP00000219235³	STRING (score=.994)
CXCL12	ENSP00000363548³	STRING (score=.929)
CCR3	ENSP00000350003³	STRING (score=.906)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IEA	--
GO:0002507	tolerance induction	IEA	--
GO:0006935	chemotaxis	TAS	7642634
GO:0006954	inflammatory response	TAS	7642634
GO:0006955	immune response	TAS	7642634

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for CCR4 available from Tocris Bioscience
10/12 Novoseek chemical compound relationships for CCR4 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tarc	96.88	147	9169480 (5), 15955100 (4), 17546636 (4), 15788694 (4) (see all 74)
rantes	79.28	21	9169480 (2), 16211583 (2), 18691293 (2), 12270118 (2) (see all 16)
ccl3	75.37	2	11145678 (1), 14747532 (1)
larc	61.31	2	9169480 (1), 9365118 (1)
teck	57.03	1	15996192 (1)
ccl4	44.19	3	11145678 (1), 14747532 (1), 15319172 (1)
[alcl]	33.81	5	12181269 (2), 15289861 (1)
calcium	16.56	15	16815309 (2), 9169480 (2), 16614259 (2), 9743322 (1) (see all 11)
lipid	0.95	1	14971049 (1)
zinc	0.00	1	16967204 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCR4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCR4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005508

Sigma-Aldrich siRNA and siRNA Panels for CCR4

Sigma-Aldrich shRNA Panels and shRNA for CCR4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005508

REFSEQ mRNAs for CCR4 gene:

NM_005508.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005508

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005508
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005508
                                 untagged cDNA clone in CMV expression vector: NM_005508

Additional cDNA sequence:

AK292674.1 BC069139.1 BC071751.1 BC074935.2

2 DOTS entries:

DT.100731833 DT.40117006

11 AceView cDNA sequences:

BC069139 NM_005508 BC074935 CD640816 BC071751 CN838882 CD639869 CN839223

CB269299 CB269413 X85740

highest scoring ESTs for CCR4:

BC069139 CN838882 X85740 BC071751 BC074935 CD639869 CD640816 CN839223 NM_005508 CB269299

Unigene Cluster for CCR4:

Chemokine (C-C motif) receptor 4

Hs.184926 [show with all ESTs]

Unigene Representative Sequence: BC071751

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000330953

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CCR4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CCR4

¹ / ² / ³

3 probe-sets matching CCR4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
390_at²^{, 3}	U95-A	1	0.94	1.00	1.00	1.00	X85740	0.80	1.00	0.91	1
208376_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005508	0.60	1.00	0.82	1
208376_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTGTTCTA

SOURCE GeneReport for Unigene cluster: Hs.184926
Expression variation in blood from EXPOLDB for CCR4
UniProtKB/Swiss-Prot: CCR4_HUMAN, P51679
Tissue specificity: Predominantly expressed in the thymus, in peripheral blood leukocytes,
including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the
spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and
skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA).
Expressed in brain microvascular and coronary artery endothelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CCR4 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CCR4¹	--	chemokine (C-C motif) receptor 4	87.59(n) 91.94(a)	403541 NM_001003020.1 NP_001003020.1
chimpanzee (Pan troglodytes)	CCR4¹	--	chemokine (C-C motif) receptor 4	99.91(n) 100(a)	470781 XM_001168244.1 XP_001168244.1
cow (Bos taurus)	CCR4¹	--	chemokine (C-C motif) receptor 4	87.09(n) 89.97(a)	408019 XM_592796.3 XP_592796.1
rat (Rattus norvegicus)	Ccr4¹	--	chemokine (C-C motif) receptor 4	81.48(n) 87.5(a)	171054 NM_133532.2 NP_598216.2
mouse (Mus musculus)	Ccr4^{1, 5}	9 (61.00 cM)⁵	chemokine (C-C motif) receptor 4^{1, 5}	82.87(n)¹ 85.83(a)¹	12773¹ NM_009916.1¹ NP_034046.1¹ BC117041⁵ BC119171⁵ (see all 7)

About this table Species with no ortholog for CCR4

ENSEMBL Gene Tree for CCR4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CCR4 gene

CCRL2² CCR2² CCR5² ENSG00000215782² CCR3² ENSG00000215775² ENSG00000215778² CCR1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/25 NCBI SNPs in CCR4 are shown (see all 25 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 18)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7632357^1,2	A,C,F,H	32967207(+)	`CTGACT/GCAAAA`	1	--	ng5¹		4		EU EA WA	412
	rs6770096^1,2	C,F,H	32971513(+)	`ATTAGC/TGAAGT`	1	--	ng3¹		8		EU EA WA	838
--	rs11129538^1,2	A,C	32966293(+)	`ggtgcA/Ggtggc`	1	--	ng5¹		0	--	--	--	--
	rs2228428^1,2	C,F,H	32970932(+)	`ATTTAC/TTCTGC`	1	Y/Y	syn¹ ese³		13		MN EU EA WA	1328
--	rs6550178^1,2	A,C,F,H	32968496(+)	`CACACG/ACAAGG`	1	--	int¹		4		EU EA WA	412
--	rs62250867^1,2	--	32966967(+)	`AGAAAA/GAATGA`	1	--	ng5¹		0	--	--	--	--
--	rs59752252^1,2	--	32969919(+)	`AAAAA-/ATGAAC`	1	N	fra¹		0	--	--	--	--
--	rs61736865^1,2	--	32970888(+)	`GCAGGA/GGCCTT`	1	G/S	mis¹		0	--	--	--	--
--	rs41357148^1,2	--	32971766(+)	`GGGCAC/TGGTGG`	1	--	ng3¹		0	--	--	--	--
--	rs71903231^1,2	--	32968106(+)	`ACCGG-/GTCCTT`	1	--	ut5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for CCR4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604836

10/49 Novoseek disease relationships for CCR4 gene (see all 49 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mycosis fungoides	66.94	11	14708605 (2), 12393570 (1), 16713487 (1), 10887135 (1) (see all 9)
sezary syndrome	65.13	7	17546636 (2), 12393570 (1), 15727636 (1), 19239991 (1) (see all 5)
dermatitis atopic	62.98	35	11511293 (7), 15202833 (4), 10998136 (2), 12598706 (2) (see all 13)
lymphoma t-cell cutaneous	58.60	4	19242508 (1), 15727636 (1), 19239991 (1)
lymphoma t-cell peripheral	56.64	5	15328188 (2), 11979374 (1), 12645345 (1), 18842429 (1)
leukemia t-cell	55.84	4	11861261 (2), 15026353 (1), 18178833 (1)
lymphoma t-cell	51.58	9	12485447 (4), 18842429 (1), 15328188 (1), 16931956 (1)
inflammation	51.29	30	16918452 (2), 12009564 (2), 11786428 (1), 14657875 (1) (see all 19)
anaplastic large cell lymphoma	49.68	2	15328188 (1), 12181269 (1)
fibrosis idiopathic pulmonary	49.47	1	17137778 (1)

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Genetic Association Database: CCR4
Human Genome Epidemiology Navigator: CCR4 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/392 PubMed articles for CCR4 gene (see all 392 ):

New variations of human CC-chemokine receptors CCR3 and CCR4. (PubMed id 11196669)^{1, 3, 4, 6} Kato H.... Tokunaga K. (1999)
Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. (PubMed id 7642634)^{2, 3, 4} Power C.A.... Wells T.N.C. (1995)
Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. (PubMed id 10754297)^{1, 3, 4} Inngjerdingen M.... Maghazachi A.A. (2000)
The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. (PubMed id 9169480)^{1, 3, 4} Imai T.... Yoshie O. (1997)
Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PubMed id 9430724)^{1, 3, 4} Imai T.... Gray P.W. (1998)
Lack of association of CCR4 single nucleotide polymorphism with atopic dermatitis in Japanese patients. (PubMed id 15202833)^{1, 3, 6} Tsunemi Y....Tamaki K. (2004)
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. (PubMed id 10466728)^{1, 3, 4} Campbell J.J.... Butcher E.C. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3. (PubMed id 8884276)^{2, 3} Samson M....Parmentier M. (1996)
Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. (PubMed id 11861261)^{1, 3} Yoshie O....Yamada Y. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1233	HGNC: 1605	AceView: CCR4	Ensembl:ENSG00000183813	euGenes: HUgn1233
ECgene: CCR4	H-InvDB: CCR4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/CC_chemokine_receptors

Licensable Technologies for CCR4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CCR4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CCR4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CCR4		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CCR4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for CCR4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CCR4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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CCR4 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CCR4

Summaries
for CCR4

Genomic Location
for CCR4

Proteins
for CCR4

Protein Domains/
Families
for CCR4

Gene Function
for CCR4

Pathways & Interactions
for CCR4

Drugs & Compounds
for CCR4

Transcripts
for CCR4

Expression
for CCR4

Orthologs
for CCR4

Paralogs
for CCR4

SNPs/Variants
for CCR4

Disorders & Mutations
for CCR4

Medical News
for CCR4

Publications
for CCR4

Search for CCR4

Genome Databases showing CCR4

Other Databases showing CCR4

Specialized Databases showing CCR4

Licensable Technologies
for CCR4

Services
for CCR4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CCR4 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CCR4

Summariesfor CCR4

Genomic Locationfor CCR4

Proteinsfor CCR4

Protein Domains/Familiesfor CCR4

Gene Functionfor CCR4

Pathways & Interactionsfor CCR4

Drugs & Compoundsfor CCR4

Transcriptsfor CCR4

Expression for CCR4

Orthologsfor CCR4

Paralogsfor CCR4

SNPs/Variantsfor CCR4

Disorders & Mutationsfor CCR4

Medical Newsfor CCR4

Publicationsfor CCR4

Search for CCR4

Genome Databases showing CCR4

Other Databases showing CCR4

Specialized Databases showing CCR4

Licensable Technologiesfor CCR4

Servicesfor CCR4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CCR4

Summaries
for CCR4

Genomic Location
for CCR4

Proteins
for CCR4

Protein Domains/
Families
for CCR4

Gene Function
for CCR4

Pathways & Interactions
for CCR4

Drugs & Compounds
for CCR4

Transcripts
for CCR4

Expression
for CCR4

Orthologs
for CCR4

Paralogs
for CCR4

SNPs/Variants
for CCR4

Disorders & Mutations
for CCR4

Medical News
for CCR4

Publications
for CCR4

Licensable Technologies
for CCR4

Services
for CCR4