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Aliases for CCR4 Gene

Aliases for CCR4 Gene

  • C-C Motif Chemokine Receptor 4 2 3 5
  • Chemokine (C-C Motif) Receptor 4 2 3
  • C-C CKR-4 3 4
  • CC-CKR-4 3 4
  • CMKBR4 3 4
  • CCR-4 3 4
  • K5-5 3 4
  • C-C Chemokine Receptor Type 4 3
  • Chemokine (C-C) Receptor 4 3
  • CD194 Antigen 4
  • HGCN:14099 3
  • ChemR13 3
  • CD194 3
  • CKR4 3

External Ids for CCR4 Gene

Previous GeneCards Identifiers for CCR4 Gene

  • GC03U990019
  • GC03P032841
  • GC03P032966
  • GC03P032964

Summaries for CCR4 Gene

Entrez Gene Summary for CCR4 Gene

  • The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR4 Gene

CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include Cutaneous T Cell Lymphoma and Mycosis Fungoides. Among its related pathways are Peptide ligand-binding receptors and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. GO annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR1.

UniProtKB/Swiss-Prot for CCR4 Gene

  • High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Tocris Summary for CCR4 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Gene Wiki entry for CCR4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR4 Gene

Genomics for CCR4 Gene

Regulatory Elements for CCR4 Gene

Enhancers for CCR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G033047 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.9 +96.6 96554 1.2 MTA2 NR2F1 BHLHE40 JUNB DPF2 TBX21 ZBTB40 GABPA RAD51 ARID3A CCR4 SEC13P1 SUMO2P10
GH03G033044 0.9 FANTOM5 ENCODE dbSUPER 18.5 +93.2 93187 0.3 ATF2 CCR4 GLB1 TMPPE CRTAP SEC13P1 SUMO2P10
GH03G033716 1.5 FANTOM5 ENCODE 10.8 +766.3 766305 2.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A ZNF2 YY1 CCR4 FBXL2 CLASP2 UBP1 GC03M033663 GC03M033664
GH03G033019 0.4 FANTOM5 22 +67.9 67896 0.3 FOXA2 FOXA1 CCR4 SUGT1P2 CNOT10-AS1 CNOT10 GLB1 TMPPE CRTAP SEC13P1 LOC105377022
GH03G032455 2 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -492.4 -492354 8.0 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 CMTM6 CMTM7 CCR4 CNOT10 GC03P032466 GC03M031988
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCR4 Gene

Chromosome:
3
Start:
32,951,574 bp from pter
End:
32,956,349 bp from pter
Size:
4,776 bases
Orientation:
Plus strand

Genomic View for CCR4 Gene

Genes around CCR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR4 Gene

Proteins for CCR4 Gene

  • Protein details for CCR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51679-CCR4_HUMAN
    Recommended name:
    C-C chemokine receptor type 4
    Protein Accession:
    P51679
    Secondary Accessions:
    • Q9ULY6
    • Q9ULY7

    Protein attributes for CCR4 Gene

    Size:
    360 amino acids
    Molecular mass:
    41403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR4 Gene

Post-translational modifications for CCR4 Gene

  • In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
  • Glycosylation at posLast=183183 and Asn194
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCR4 Gene

Domains & Families for CCR4 Gene

Gene Families for CCR4 Gene

Suggested Antigen Peptide Sequences for CCR4 Gene

Graphical View of Domain Structure for InterPro Entry

P51679

UniProtKB/Swiss-Prot:

CCR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR4: view

Function for CCR4 Gene

Molecular function for CCR4 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 4,with high affinity binding for basophil chemoattractant,G protein coupled receptor superfamily,specific receptor for thymus and activation-regulated chemokine
UniProtKB/Swiss-Prot Function:
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Gene Ontology (GO) - Molecular Function for CCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004950 chemokine receptor activity TAS 7642634
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR4: view
genes like me logo Genes that share phenotypes with CCR4: view

Animal Models for CCR4 Gene

MGI Knock Outs for CCR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCR4

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCR4
  • Applied Biological Materials Clones for CCR4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCR4 Gene

Localization for CCR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR4 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7642634
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCR4: view

Pathways & Interactions for CCR4 Gene

genes like me logo Genes that share pathways with CCR4: view

Gene Ontology (GO) - Biological Process for CCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0002507 tolerance induction IEA --
GO:0006935 chemotaxis IEA,TAS --
GO:0006954 inflammatory response IEA,TAS --
GO:0006955 immune response TAS,IEA --
genes like me logo Genes that share ontologies with CCR4: view

No data available for SIGNOR curated interactions for CCR4 Gene

Drugs & Compounds for CCR4 Gene

(24) Drugs for CCR4 Gene - From: ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Procaine Approved, Investigational, Vet_approved Pharma Channel blocker 49
Plerixafor Approved Pharma Agonist, antagonist 0
C 021 dihydrochloride Pharma Potent CCR4 antagonist 0
CCL17 Pharma Full agonist, Agonist 0
CCL22 Pharma Full agonist, Agonist 0

(12) Additional Compounds for CCR4 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL17
Full agonist, Agonist
[<sup>125</sup>I]CCL27
Agonist

(5) Tocris Compounds for CCR4 Gene

Compound Action Cas Number
BMS CCR2 22 High affinity, potent CCR2 antagonist 445479-97-0
C 021 dihydrochloride Potent CCR4 antagonist 864289-85-0
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3

(1) ApexBio Compounds for CCR4 Gene

Compound Action Cas Number
C 021 dihydrochloride Potent CCR4 antagonist 864289-85-0
genes like me logo Genes that share compounds with CCR4: view

Drug Products

Transcripts for CCR4 Gene

mRNA/cDNA for CCR4 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCR4 Gene

Chemokine (C-C motif) receptor 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCR4
  • Applied Biological Materials Clones for CCR4

Alternative Splicing Database (ASD) splice patterns (SP) for CCR4 Gene

No ASD Table

Relevant External Links for CCR4 Gene

GeneLoc Exon Structure for
CCR4
ECgene alternative splicing isoforms for
CCR4

Expression for CCR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCR4 Gene

mRNA differential expression in normal tissues according to GTEx for CCR4 Gene

This gene is overexpressed in Whole Blood (x15.8), Spleen (x4.7), and Lung (x4.6).

Protein differential expression in normal tissues from HIPED for CCR4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR4 Gene



Protein tissue co-expression partners for CCR4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCR4 Gene:

CCR4

SOURCE GeneReport for Unigene cluster for CCR4 Gene:

Hs.184926

mRNA Expression by UniProt/SwissProt for CCR4 Gene:

P51679-CCR4_HUMAN
Tissue specificity: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.

Evidence on tissue expression from TISSUES for CCR4 Gene

  • Blood(4.3)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with CCR4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR4 Gene

Orthologs for CCR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR4 34 35
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia CCR4 34 35
  • 87.59 (n)
cow
(Bos Taurus)
Mammalia CCR4 34 35
  • 87.09 (n)
mouse
(Mus musculus)
Mammalia Ccr4 34 16 35
  • 82.96 (n)
rat
(Rattus norvegicus)
Mammalia Ccr4 34
  • 81.48 (n)
oppossum
(Monodelphis domestica)
Mammalia CCR4 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCR4 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCR4 34 35
  • 63.29 (n)
lizard
(Anolis carolinensis)
Reptilia CCR4 35
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100329837 34
  • 52.35 (n)
BX511173.1 35
  • 40 (a)
ManyToMany
BX537113.1 35 35
  • 40 (a)
ManyToMany
ccr8.1 35 35
  • 37 (a)
ManyToMany
CABZ01093075.1 35
  • 34 (a)
ManyToMany
Species where no ortholog for CCR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR4 Gene

ENSEMBL:
Gene Tree for CCR4 (if available)
TreeFam:
Gene Tree for CCR4 (if available)

Paralogs for CCR4 Gene

Variants for CCR4 Gene

Sequence variations from dbSNP and Humsavar for CCR4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000863052 -- 32,952,484(+) GAGCT(C/T)CTTGG intron-variant
rs1000927514 -- 32,952,981(+) ACCCA(A/G)TTGAG intron-variant
rs1001107718 -- 32,952,712(+) AGCAA(C/G)GGAGT intron-variant
rs1001455593 -- 32,951,758(+) AGATG(C/T)TCAGG intron-variant
rs1001599783 -- 32,950,672(+) GCAAT(C/T)CCCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCR4 Gene

Variant ID Type Subtype PubMed ID
nsv1003285 CNV gain 25217958
nsv508909 CNV insertion 20534489
nsv998302 CNV gain 25217958

Variation tolerance for CCR4 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR4 Gene

Disorders for CCR4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CCR4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
mycosis fungoides
  • mf
alk-negative anaplastic large cell lymphoma
  • alk- alcl
sezary's disease
  • sezary disease
pustulosis palmaris et plantaris
  • localized pustular psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search CCR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR4

Genetic Association Database (GAD)
CCR4
Human Genome Epidemiology (HuGE) Navigator
CCR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR4
genes like me logo Genes that share disorders with CCR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR4 Gene

Publications for CCR4 Gene

  1. New variations of human CC-chemokine receptors CCR3 and CCR4. (PMID: 11196669) Kato H. … Tokunaga K. (Genes Immun. 1999) 3 4 22 46 64
  2. Association screen for atopic dermatitis candidate gene regions using microsatellite markers in pooled DNA samples. (PMID: 17117949) Hoffjan S. … Epplen J.T. (Int. J. Immunogenet. 2006) 3 22 46 64
  3. Lack of association of CCR4 single nucleotide polymorphism with atopic dermatitis in Japanese patients. (PMID: 15202833) Tsunemi Y. … Tamaki K. (Acta Derm. Venereol. 2004) 3 22 46 64
  4. Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. (PMID: 10754297) Inngjerdingen M. … Maghazachi A.A. (J. Immunol. 2000) 3 4 22 64
  5. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. (PMID: 10466728) Campbell J.J. … Butcher E.C. (Nature 1999) 3 4 22 64

Products for CCR4 Gene

  • Addgene plasmids for CCR4

Sources for CCR4 Gene

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