CCR3 Gene
protein-coding GIFtS: 66
GCID: GC03P046227
|
|
chemokine (C-C motif) receptor 3
(Previous symbol: CMKBR3)
| |
Aliases
for CCR3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chemokine (C-C Motif) Receptor 31 2 | | C-C CKR-32 3 | | CKR31 2 3 5 | | B-Chemokine Receptor2 | | CMKBR31 2 3 5 | | C-C Chemokine Receptor Type 32 | | CC-CKR-31 2 3 | | CC Chemokine Receptor 32 | | CD1931 2 | | Eosinophil CC Chemokine Receptor 32 | | Eosinophil Eotaxin Receptor2 3 | | CD193 Antigen3 | | CCR-32 3 | | |
Export aliases for CCR3 gene to outside databasesPrevious GC identifers: GC03P045547 GC03P046024 GC03P046244 |
Summaries
for CCR3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCR3:
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupledreceptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26),MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is alsodetected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulationand activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entryco-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster onthe chromosomal region 3p21. Alternatively spliced transcript variants have been described. (provided by RefSeq, Sep2009)
UniProtKB/Swiss-Prot: CCR3_HUMAN, P51677Function: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta.Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4for HIV-1 infection
 summary
for CCR3: Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.
Gene Wiki entry for CCR3
|
Genomic Views
for CCR3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCR3 gene promoter:
STAT5B AML1a GCNF ATF-2 C/EBPalpha AREB6 c-Jun Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCR3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3CCR3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P046227: view genomic region
(about GC identifiers)
Start:
|
46,205,096 bp from pter |
End:
|
46,308,197 bp from pter |
Size:
|
103,102 bases |
Orientation:
|
plus strand |
|
Proteins
for CCR3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCR3_HUMAN, P51677 (See
protein sequence)Recommended Name: C-C chemokine receptor type 3 Size: 355 amino acids; 41044 Da
Subunit: Binds to HIV-1 Tat
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis(UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play arole in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277)
Secondary accessions: B3KVQ1 Q15748 Q2YDB9 Q86WD2 Q9ULY8Explore the universe of human proteins at neXtProt for CCR3: NX_P51677
CCR3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001158152.1 NP_001828.1 NP_847898.1 NP_847899.1
ENSEMBL proteins: ENSP00000350003 ENSP00000379271 ENSP00000389336 ENSP00000401822 ENSP00000379273 ENSP00000441600 ENSP00000440097 Reactome Protein details: P51677
Human Recombinant Protein Products for CCR3:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CCR3 for ontologies About GeneDecksing
CCR3 Antibody Products:
Assay Products for CCR3: |
Protein
Domains /
Families
for CCR3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCR3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P51677ProtoNet protein and cluster: P51677 2 Blocks protein families: IPB000355 Chemokine receptor signature IPB002238 C-C chemokine receptor type 3 signature
UniProtKB/Swiss-Prot: CCR3_HUMAN, P51677Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for CCR3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CCR3_HUMAN, P51677Function: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta.Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4for HIV-1 infection Genatlas biochemistry entry for CCR3:chemokine CC,beta,receptor 3,expressed in eosinophil,basophil and T helper 2 cell,G protein coupled receptorsuperfamily,expressed by the thymocytes for the mobilization of lymphocytes within and from the thymus
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CCR3 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CCR3:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ccr3):
CCR3 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Ccr3tm1Cge for CCR3
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR3 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): CCR3 (NM_001164680) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCR3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR3 |
|
Pathways & Interactions
for CCR3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Akt Signaling | | | 3 | Signaling by GPCR | | | 4 | Immune response _CCR3 signaling in eosinophils | | | 5 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for CCR3
5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR3 (see all 9)
1  GeneGo (Thomson Reuters) Pathway for CCR3
2  BioSystems Pathways for CCR3
5/8 
Reactome Pathways for CCR3 (see all 8)
2 
Kegg Pathways (Kegg details for CCR3):
CCR3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCR3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/188 Interacting proteins for CCR3 (P516773 ENSP000003500034) via UniProtKB, MINT, STRING, and/or I2D (see all 188)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
CCR3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCR3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CCR3 for compounds About GeneDecksing
Compounds for CCR3 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| SB 297006 | Potent and selective CCR3 antagonist | [58816-69-6] | | SB 328437 | Potent and selective CCR3 antagonist | [247580-43-4] | | UCB 35625 | Potent CCR1 and CCR3 antagonist | [301648-08-8] |
1 HMDB Compound for CCR3 About this table
10/33 Novoseek chemical compound relationships for CCR3 gene (see all 33) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rantes |
91.1 |
115 |
15948978 (6), 11404385 (4), 11240271 (4), 10570327 (3) (see all 68) |
| tarc |
78.6 |
5 |
9500790 (1), 16237112 (1), 16634894 (1), 12009564 (1) (see all 5) |
| ccl3 |
69.1 |
3 |
11145678 (1), 15588486 (1), 18492752 (1) |
| mcp 1 |
46.7 |
1 |
15607028 (1) |
| calcium |
46.3 |
38 |
18699931 (2), 12532103 (2), 11449371 (2), 8955214 (1) (see all 28) |
| piperidine |
44.3 |
2 |
17951061 (1), 14505678 (1) |
| ccl4 |
35.7 |
3 |
17133532 (1), 11145678 (1), 14607956 (1) |
| histamine |
28.5 |
1 |
15965235 (1) |
| herbimycin a |
18.6 |
5 |
10704057 (1), 10527858 (1) |
| ltd4 |
9.53 |
2 |
9365122 (1), 11408763 (1) |
Search CenterWatch for drugs/clinical trials and news about CCR3
|
Transcripts
for CCR3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCR3 gene (4 alternative transcripts): NM_001164680.1 NM_001837.3 NM_178328.1 NM_178329.2 Unigene Cluster for CCR3: Chemokine (C-C motif) receptor 3 Hs.506190 [show with all ESTs]Unigene Representative Sequence: NM_0018379 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357422(uc003cpg.2) ENST00000395940 ENST00000452454 ENST00000457243
ENST00000484025 ENST00000475150 ENST00000395942(uc021wwz.1) ENST00000545097(uc003cpk.2 uc010hjb.2 uc003cpj.2 uc003cpl.2)
ENST00000541018(uc003cpi.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR3 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): CCR3 (NM_001164680) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCR3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR3 |
Additional cDNA sequence: AF026535.1 AF224495.1 AF262299.1 AF262300.1 AF262301.1 AF262302.1 AF262303.1 AF262304.1 BC110297.1 BC130318.1 BC130320.1 U28694.1 4 DOTS entries: DT.95360233 DT.307767 DT.97836291 DT.101976174 19 AceView cDNA sequences: BC033514 AF262303 AF262302 U28694 AF224495 NM_001837 AF026535 NM_178329 AF262299 BG205056 BI821796 AF262304 BG182330 BG204024 AF262300 AK123050 BI906283 AF262301 BG460984
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CCR3 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCR3
|
Expression
for CCR3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGTTTGC
About this image
See CCR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCR3
SOURCE GeneReport for Unigene cluster: Hs.506190
UniProtKB/Swiss-Prot: CCR3_HUMAN, P51677Tissue specificity: In eosinophils as well as trace amounts in neutrophils and monocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including CCR3 (see all 11):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR3 |
Orthologs
for CCR3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCR3 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for CCR3 (if available)
TreeFam Gene Tree for CCR3 (if available) |
Paralogs
for CCR3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCR3 gene
- CCR62 CCR52 CXCR62 CXCR32 XCR12 CCR92 CCBP22 CCRL22
- CCR72 CX3CR12 CCR82 CXCR22 CCRL12 CCR42 CCR12 CXCR12
- CCR22 CXCR52 CCR102 CXCR42
18/61 SIMAP similar genes for CCR3 using alignment to 9 protein entries: CCR3_HUMAN (see all proteins)
(see all similar genes):CCR-5 CCR1 CCR5 CCR2 CCRL2 GHSR
CCR4 CX3CR1 CCR8 GPR34 NMBR CCR7
NPBWR2 OPRM1 GPR18 GPR1 CXCR2 IL8RB
CCR3 for paralogs About GeneDecksing
|
Genomic Variants
for CCR3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCR3 (46205096 - 46308197 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCR3: --
Human Gene Mutation Database (HGMD): CCR3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR3 |
|
Disorders
/ Diseases
for CCR3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCR3 for disorders About GeneDecksing
OMIM gene information: 601268
OMIM disorders: --
20/92  diseases for CCR3 (see all 92): About MalaCardserdheim-chester disease toxic epidermal necrolysis stevens-johnson syndrome aids dementia complex
hematopoiesis age related macular degeneration human immunodeficiency virus infectious disease lymphomatoid papulosis
mycosis fungoides gastroesophageal reflux disease allergic rhinitis erythema multiforme
severe combined immunodeficiency pulmonary eosinophilia wegener's granulomatosis optic neuritis
macular degeneration bullous pemphigoid chronic obstructive pulmonary disease eosinophilia
5 diseases from the University of Copenhagen DISEASES database for CCR3:Asthma Eosinophilia Hypersensitivity reaction type I disease Atopic dermatitis
Allergic rhinitis 10/48 Novoseek disease relationships for CCR3 gene (see all 48) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| immunodeficiency |
65.1 |
28 |
9573273 (2), 9343175 (2), 17041228 (2), 19218218 (2) (see all 19) |
| asthma |
63.9 |
56 |
17845580 (4), 14561201 (3), 11307756 (2), 11060659 (2) (see all 39) |
| inflammation |
60.7 |
46 |
20144207 (3), 16889234 (2), 12009564 (2), 7622448 (1) (see all 33) |
| eosinophilia |
54.4 |
7 |
17983872 (2), 14698143 (1), 18699933 (1), 10708591 (1) (see all 5) |
| aids dementia complex |
52.7 |
1 |
11115360 (1) |
| asthma allergic |
45.1 |
6 |
15322211 (1), 9893192 (1), 17929797 (1), 19960358 (1) (see all 6) |
| airways disease |
43.7 |
4 |
14698143 (1), 19637977 (1), 17350279 (1) |
| dermatitis atopic |
42.4 |
13 |
10417617 (4), 15948978 (2), 16045735 (1), 14581140 (1) (see all 8) |
| allergic rhinitis |
42.3 |
6 |
20144207 (2), 16623955 (1), 17156343 (1), 10529603 (1) (see all 5) |
| allergy |
40.2 |
11 |
20082620 (2), 14561201 (2), 14561176 (2), 17845580 (1) (see all 7) |
Genetic Association Database (GAD): CCR3
Human Genome Epidemiology (HuGE) Navigator: CCR3 (45 documents)
Export disorders for CCR3 gene to outside databases
|
Publications
for CCR3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCR3 gene, integrated from 9 sources (see all 682):
(articles sorted by number of sources associating them with CCR3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- New variations of human CC-chemokine receptors CCR3 and CCR4. (PubMed id 11196669)1, 2, 4, 9 Kato H.... Tokunaga K. (1999)
- Cloning, expression, and characterization of the human eosinophil eotaxin receptor. (PubMed id 8642344)1, 2, 9 Daugherty B.L.... Springer M.S. (1996)
- Cloning and functional expression of a human eosinophil CC chemokine receptor. (PubMed id 7622448)1, 2, 9 Combadiere C.... Murphy P.M. (1995)
- Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics. (PubMed id 11307756)1, 4, 9 Fukunaga K....Yamaguchi K. (2001)
- Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. (PubMed id 8676064)1, 2, 9 Ponath P.D.... Mackay C.R. (1996)
- Association of interleukin 10 haplotype with low bone mineral density in Korean postmenopausal women. (PubMed id 15607028)1, 4, 9 Park B.L....Shin H.D. (2004)
- Genetic variants in the CCR gene cluster and spontaneous viral elimination in hepatitis C-infected patients. (PubMed id 15086398)1, 4, 9 Mascheretti S....Schreiber S. (2004)
- HIV-1 Tat protein mimicry of chemokines. (PubMed id 9789057)1, 2, 9 Albini A.... Noonan D.M. (1998)
- Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies. (PubMed id 21077277)1, 2 Manousou P.... Kouroumalis E. (2010)
- The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis. (PubMed id 15580493)1, 4 Chae S.C....Chung H.T. (2005)
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External Searches for CCR3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CCR3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CCR3 gene
(According to HUGE)
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Specialized Databases showing CCR3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CCR3 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/CC_chemokine_receptors |
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| Patent Information for CCR3 gene:
Search GeneIP for patents involving CCR3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CCR3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for CCR3 | | OriGene shRNA RFP for CCR3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCR3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR3 | | | OriGene Protein Over-expression Lysate for CCR3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCR3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCR3 | | OriGene Custom Protein Services for CCR3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCR3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR3 |
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| | | | Tocris compounds for CCR3 |
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 | | | CCR3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR3 |
|  |  |  |  | | | | ThermoFisher Antibodies for CCR3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR3 |
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