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Aliases for CCR3 Gene

Aliases for CCR3 Gene

  • C-C Motif Chemokine Receptor 3 2 3
  • Chemokine (C-C Motif) Receptor 3 2 3 5
  • Eosinophil Eotaxin Receptor 3 4
  • C-C CKR-3 3 4
  • CC-CKR-3 3 4
  • CMKBR3 3 4
  • CCR-3 3 4
  • CKR3 3 4
  • Eosinophil CC Chemokine Receptor 3 3
  • CC Chemokine Receptor 3 3
  • B-Chemokine Receptor 3
  • CD193 Antigen 4
  • CD193 3

External Ids for CCR3 Gene

Previous HGNC Symbols for CCR3 Gene

  • CMKBR3

Previous GeneCards Identifiers for CCR3 Gene

  • GC03P045547
  • GC03P046024
  • GC03P046244

Summaries for CCR3 Gene

Entrez Gene Summary for CCR3 Gene

  • The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

GeneCards Summary for CCR3 Gene

CCR3 (C-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CCR3 include erdheim-chester disease and hiv-1. Among its related pathways are Chemokine Signaling and PEDF Induced Signaling. GO annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CCR3 Gene

  • Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Tocris Summary for CCR3 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Gene Wiki entry for CCR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR3 Gene

Genomics for CCR3 Gene

Regulatory Elements for CCR3 Gene

Enhancers for CCR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCR3 Gene

Chromosome:
3
Start:
46,163,604 bp from pter
End:
46,266,706 bp from pter
Size:
103,103 bases
Orientation:
Plus strand

Genomic View for CCR3 Gene

Genes around CCR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR3 Gene

Proteins for CCR3 Gene

  • Protein details for CCR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51677-CCR3_HUMAN
    Recommended name:
    C-C chemokine receptor type 3
    Protein Accession:
    P51677
    Secondary Accessions:
    • B3KVQ1
    • F5GWL6
    • Q15748
    • Q2YDB9
    • Q86WD2
    • Q8TDP6
    • Q9ULY8

    Protein attributes for CCR3 Gene

    Size:
    355 amino acids
    Molecular mass:
    41044 Da
    Quaternary structure:
    • Binds to HIV-1 Tat.
    Miscellaneous:
    • Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).

    Alternative splice isoforms for CCR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR3 Gene

Proteomics data for CCR3 Gene at MOPED

Post-translational modifications for CCR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CCR3 Gene

Domains & Families for CCR3 Gene

Gene Families for CCR3 Gene

Graphical View of Domain Structure for InterPro Entry

P51677

UniProtKB/Swiss-Prot:

CCR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR3: view

Function for CCR3 Gene

Molecular function for CCR3 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 3,expressed in eosinophil,basophil and T helper 2 cell,G protein coupled receptor superfamily,expressed by the thymocytes for the mobilization of lymphocytes within and from the thymus
UniProtKB/Swiss-Prot Function:
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
genes like me logo Genes that share phenotypes with CCR3: view

Animal Models for CCR3 Gene

MGI Knock Outs for CCR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCR3 Gene

Localization for CCR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR3 Gene COMPARTMENTS Subcellular localization image for CCR3 gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CCR3: view

Pathways & Interactions for CCR3 Gene

genes like me logo Genes that share pathways with CCR3: view

Gene Ontology (GO) - Biological Process for CCR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0007155 cell adhesion TAS 10201960
GO:0045766 positive regulation of angiogenesis IEA,IMP 19525930
GO:0070098 chemokine-mediated signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with CCR3: view

No data available for SIGNOR curated interactions for CCR3 Gene

Drugs & Compounds for CCR3 Gene

(52) Drugs for CCR3 Gene - From: ClinicalTrials, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]CCL11 (human) Pharma Antagonist 0
[<sup>125</sup>I]CCL5 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]CCL7 (human) Pharma Full agonist, Agonist 0
[<sup>3</sup>H]banyu (I) Pharma Inverse agonist, Antagonist 0
banyu (I) Pharma Inverse agonist, Antagonist 0

(18) Additional Compounds for CCR3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Met-Ckbeta7
Antagonist
DAPTA
106362-34-9
J 113863
353791-85-2
RS 102895 hydrochloride
1173022-16-6

(5) Tocris Compounds for CCR3 Gene

Compound Action Cas Number
DAPTA Chemokine receptor 5 (CCR5) antagonist 106362-34-9
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3
ZK 756326 Selective, non-peptide CCR8 agonist 874911-96-3
genes like me logo Genes that share compounds with CCR3: view

Transcripts for CCR3 Gene

Unigene Clusters for CCR3 Gene

Chemokine (C-C motif) receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCR3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: -

Relevant External Links for CCR3 Gene

GeneLoc Exon Structure for
CCR3
ECgene alternative splicing isoforms for
CCR3

Expression for CCR3 Gene

mRNA expression in normal human tissues for CCR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR3 Gene

This gene is overexpressed in Whole Blood (x40.3).

Protein differential expression in normal tissues from HIPED for CCR3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR3 Gene



SOURCE GeneReport for Unigene cluster for CCR3 Gene Hs.506190

mRNA Expression by UniProt/SwissProt for CCR3 Gene

P51677-CCR3_HUMAN
Tissue specificity: In eosinophils as well as trace amounts in neutrophils and monocytes.
genes like me logo Genes that share expression patterns with CCR3: view

Protein tissue co-expression partners for CCR3 Gene

Primer Products

In Situ Assay Products

Orthologs for CCR3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCR3 35
  • 79.47 (n)
  • 74.86 (a)
CCR3 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR3 35
  • 77.62 (n)
  • 70.03 (a)
CCR3 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr3 35
  • 77.01 (n)
  • 70.11 (a)
Ccr3 16
Ccr3 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCR3 35
  • 99.25 (n)
  • 98.59 (a)
CCR3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr3 35
  • 76.53 (n)
  • 69.25 (a)
oppossum
(Monodelphis domestica)
Mammalia CCR3 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCR3 36
  • 59 (a)
OneToOne
Species with no ortholog for CCR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR3 Gene

ENSEMBL:
Gene Tree for CCR3 (if available)
TreeFam:
Gene Tree for CCR3 (if available)

Paralogs for CCR3 Gene

genes like me logo Genes that share paralogs with CCR3: view

Variants for CCR3 Gene

Sequence variations from dbSNP and Humsavar for CCR3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_010668 -
rs4987125 - 46,265,220(+) CGTGG(A/G)CCTGC reference, missense
rs5742906 - 46,265,274(+) GCCCC(C/T)GCTGT reference, missense
rs1907635 -- 46,256,625(-) ctgtt(A/G)taccc intron-variant
rs1907636 -- 46,251,808(-) gtgac(C/T)cccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCR3 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294

Variation tolerance for CCR3 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR3 Gene

HapMap Linkage Disequilibrium report
CCR3
Human Gene Mutation Database (HGMD)
CCR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR3 Gene

Disorders for CCR3 Gene

MalaCards: The human disease database

(13) MalaCards diseases for CCR3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
erdheim-chester disease
  • ecd
hiv-1
  • aids, slow progression to
kimura disease
  • angiolymphoid hyperplasia with eosinophilia
allergic hypersensitivity disease
  • allergic disease
testicular leukemia
- elite association - COSMIC cancer census association via MalaCards
Search CCR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR3

Genetic Association Database (GAD)
CCR3
Human Genome Epidemiology (HuGE) Navigator
CCR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR3
genes like me logo Genes that share disorders with CCR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR3 Gene

Publications for CCR3 Gene

  1. New variations of human CC-chemokine receptors CCR3 and CCR4. (PMID: 11196669) Kato H. … Tokunaga K. (Genes Immun. 1999) 3 4 23 48 67
  2. Association of the CCR3 gene polymorphism with aspirin exacerbated respiratory disease. (PMID: 20022477) Kim S.H. … Park H.S. (Respir Med 2010) 3 23
  3. Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia. (PMID: 19218218) Agrawal L. … Strayer D.S. (J. Gen. Virol. 2009) 3 23
  4. CCR3 is a target for age-related macular degeneration diagnosis and therapy. (PMID: 19525930) Takeda A. … Ambati J. (Nature 2009) 3 23
  5. Interplay between signaling via the formyl peptide receptor (FPR) and chemokine receptor 3 (CCR3) in human eosinophils. (PMID: 19414538) Svensson L. … WennerAYs C. (J. Leukoc. Biol. 2009) 3 23

Products for CCR3 Gene

Sources for CCR3 Gene

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