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CCR3 Gene

protein-coding   GIFtS: 69
GCID: GC03P046227

Chemokine (C-C Motif) Receptor 3


(Previous symbol: CMKBR3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Receptor 31 2     CD1932
CMKBR31 2 3 5     B-Chemokine Receptor2
CKR32 3 5     C-C Chemokine Receptor Type 32
Eosinophil Eotaxin Receptor2 3     CC Chemokine Receptor 32
CC-CKR-32 3     Eosinophil CC Chemokine Receptor 32
CCR-32 3     CD193 Antigen3
C-C CKR-32 3     

External Ids:    HGNC: 16041   Entrez Gene: 12322   Ensembl: ENSG000001836257   OMIM: 6012685   UniProtKB: P516773   

Export aliases for CCR3 gene to outside databases

Previous GC identifers: GC03P045547 GC03P046024 GC03P046244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCR3 Gene:
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G
protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin
(CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils
and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor
may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic
airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes
form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants
have been described. (provided by RefSeq, Sep 2009)

GeneCards Summary for CCR3 Gene:
CCR3 (chemokine (C-C motif) receptor 3) is a protein-coding gene. Diseases associated with CCR3 include aids dementia complex, and erdheim-chester disease. GO annotations related to this gene include C-C chemokine receptor activity and chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCR3_HUMAN, P51677
Function: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta.
Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with
CD4 for HIV-1 infection

summary for CCR3 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCR3 gene promoter:
         STAT5B   AML1a   GCNF   ATF-2   C/EBPalpha   AREB6   c-Jun   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR3 promoter sequence
   Search Chromatin IP Primers for CCR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

CCR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P046227:  view genomic region     (about GC identifiers)

Start:
46,205,096 bp from pter      End:
46,308,197 bp from pter
Size:
103,102 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCR3_HUMAN, P51677 (See protein sequence)
Recommended Name: C-C chemokine receptor type 3  
Size: 355 amino acids; 41044 Da
Subunit: Binds to HIV-1 Tat
Miscellaneous: Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative
colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the
epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277)
Secondary accessions: B3KVQ1 F5GWL6 Q15748 Q2YDB9 Q86WD2 Q8TDP6 Q9ULY8
Alternative splicing: 2 isoforms:  P51677-1   P51677-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CCR3: NX_P51677

Explore proteomics data for CCR3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001158152.1  NP_001828.1  NP_847898.1  NP_847899.1  

    ENSEMBL proteins: 
     ENSP00000350003   ENSP00000379271   ENSP00000389336   ENSP00000401822   ENSP00000379273  
     ENSP00000441600   ENSP00000440097  
    Reactome Protein details: P51677

    CCR3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCR3
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    Novus Biologicals CCR3 Proteins
    Novus Biologicals CCR3 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCR3

    CCR3 Antibody Products:

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    Cloud-Clone Corp. CLIAs for CCR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR3
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002238 Chemokine_CCR3
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P51677

    ProtoNet protein and cluster: P51677

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB002238 C-C chemokine receptor type 3 signature


    UniProtKB/Swiss-Prot: CCR3_HUMAN, P51677
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CCR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR3_HUMAN, P51677
    Function: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta.
    Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with
    CD4 for HIV-1 infection

         Genatlas biochemistry entry for CCR3:
    chemokine CC,beta,receptor 3,expressed in eosinophil,basophil and T helper 2 cell,G protein coupled receptor
    superfamily,expressed by the thymocytes for the mobilization of lymphocytes within and from the thymus

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS10415069
    GO:0005515protein binding IPI--
    GO:0016493C-C chemokine receptor activity IEA--
         
    CCR3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCR3:
     Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccr3):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  respiratory system 

    CCR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccr3tm1Cge for CCR3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR3

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCCR3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCR3
    Predesigned siRNA for gene silencing in human, mouse, rat CCR3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCR3

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): CCR3 (NM_001164680)
    Sino Biological Human cDNA Clone for CCR3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCR3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCR3_HUMAN, P51677: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ----
    GO:0005768endosome ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9302298
    GO:0016021integral component of membrane ----

    CCR3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCR3 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    5Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCR3
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR3 (see all 9)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    1 GeneGo (Thomson Reuters) Pathway for CCR3
        Immune response CCR3 signaling in eosinophils

    2 BioSystems Pathways for CCR3
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for CCR3
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for CCR3):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Viral carcinogenesis


    CCR3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR3 (see all 11): 
              HIV Host Response in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCR3 (P516771, 3 ENSP000003500034) via UniProtKB, MINT, STRING, and/or I2D (see all 187)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL11P516711, 3, ENSP000003022344EBI-6625120,EBI-727357 I2D: score=3 STRING: ENSP00000302234
    CCL3L3P166193, ENSP000003676054I2D: score=4 STRING: ENSP00000367605
    CCL3L1P166193I2D: score=4 
    CCL7P800983, ENSP000002003074I2D: score=3 STRING: ENSP00000200307
    CCL2P135003, ENSP000002258314I2D: score=2 STRING: ENSP00000225831
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0002551mast cell chemotaxis ----
    GO:0006935chemotaxis IEA--
    GO:0006954inflammatory response IEA--
    GO:0006968cellular defense response TAS10713092

    CCR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CCR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    1 HMDB Compound for CCR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for CCR3 (CCR3) (see all 28)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCL13
    AgonistFull agonist8.7 - 10.39276730 16339911
    CCL11
    AntagonistAntagonist9.7 - 108642344
    CCL11
    AntagonistAntagonist9.5 - 108642344
    CCL24
    AgonistFull agonist8 - 9.415207250 16339911
    CCL5
    AgonistFull agonist8.5 - 9.38642344
    CCL7
    AgonistFull agonist8.6 - 9.28642344
    RO116-9132/238
    AntagonistAntagonist912070060
    CCL26
    AgonistFull agonist7.9 - 8.915207250 10488147 16339911
    CCL15
    AgonistFull agonist8.69346309
    banyu (I)
    AntagonistInverse agonist8.512450563

    Selected Novoseek inferred chemical compound relationships for CCR3 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 91.1 115 15948978 (6), 11404385 (4), 11240271 (4), 10570327 (3) (see all 68)
    tarc 78.6 5 9500790 (1), 16237112 (1), 16634894 (1), 12009564 (1) (see all 5)
    ccl3 69.1 3 11145678 (1), 15588486 (1), 18492752 (1)
    mcp 1 46.7 1 15607028 (1)
    calcium 46.3 38 18699931 (2), 12532103 (2), 11449371 (2), 8955214 (1) (see all 28)
    piperidine 44.3 2 17951061 (1), 14505678 (1)
    ccl4 35.7 3 17133532 (1), 11145678 (1), 14607956 (1)
    histamine 28.5 1 15965235 (1)
    herbimycin a 18.6 5 10704057 (1), 10527858 (1)
    ltd4 9.53 2 9365122 (1), 11408763 (1)



    CCR3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCR3 gene (4 alternative transcripts): 
    NM_001164680.1  NM_001837.3  NM_178328.1  NM_178329.2  

    Unigene Cluster for CCR3:

    Chemokine (C-C motif) receptor 3
    Hs.506190  [show with all ESTs]
    Unigene Representative Sequence: NM_001837
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357422(uc003cpg.2) ENST00000395940 ENST00000452454 ENST00000484025
    ENST00000457243 ENST00000475150 ENST00000395942(uc021wwz.1) ENST00000545097(uc003cpk.2 uc010hjb.2 uc003cpj.2 uc003cpl.2)
    ENST00000541018(uc003cpi.2)
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    GenScript: all cDNA clones in your preferred vector (see all 4): CCR3 (NM_001164680)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR3
    Primer
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    OriGene qPCR primer pairs and template standards for CCR3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCR3
      QuantiTect SYBR Green Assays in human, mouse, rat CCR3
      QuantiFast Probe-based Assays in human, mouse, rat CCR3

    Additional mRNA sequence: 

    AF026535.1 AF224495.1 AF262299.1 AF262300.1 AF262301.1 AF262302.1 AF262303.1 AF262304.1 
    BC110297.1 BC130318.1 BC130320.1 U28694.1 

    4 DOTS entries:

    DT.95360233  DT.307767  DT.97836291  DT.101976174 

    19 AceView cDNA sequences:

    U28694 AF026535 NM_178329 BC033514 AF262302 NM_001837 AF262303 AF224495 
    AF262299 AF262304 BG204024 AK123050 BI906283 BG205056 BG182330 AF262300 
    BI821796 AF262301 BG460984 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCR3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
    SP1:                    -     -     -     -     -                     
    SP2:                                -     -     -                     
    SP3:                          -     -           -                     
    SP4:                          -     -     -     -                     
    SP5:                          -     -                                 


    ECgene alternative splicing isoforms for CCR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGTTTGC
    CCR3 Expression
    About this image


    CCR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Granulocytes Peripheral Blood
             neutrophils   
    CCR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506190

    UniProtKB/Swiss-Prot: CCR3_HUMAN, P51677
    Tissue specificity: In eosinophils as well as trace amounts in neutrophils and monocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR3 (see all 11): 
              HIV Host Response in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCR3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr31 , 5 chemokine (C-C motif) receptor 31, 5 77.01(n)1
    70.11(a)1
      9 (75.05 cM)5
    127711  NM_009914.41  NP_034044.31 
     1240219715 


    ENSEMBL Gene Tree for CCR3 (if available)
    TreeFam Gene Tree for CCR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCR3 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  
    CCR22  CXCR52  CCR102  CXCR42  
    Selected SIMAP similar genes for CCR3 using alignment to 7 protein entries:     CCR3_HUMAN (see all proteins) (see all similar genes):
    CCR-5    CCR1    CCR5    CCR2    CCRL2    KISS1R
    CCR4    CCR8    GPR34    NMBR    CX3CR1    NPBWR2
    OPRM1    CCR7    ACKR2    CXCR2    IL8RB    XCR1

    CCR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCR3 (see all 663)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922934801,2
    --46281982(+) TCCCTC/TGGGCC 4 -- us2k10--------
    rs575093591,2
    C,F--46282127(+) TGAGTG/TGCTGC 4 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1840817101,2
    C--46282164(+) TGACAA/GCTATG 4 -- us2k10--------
    rs98427161,2
    C,F,A,H--46282174(+) GATAAG/ATATTT 4 -- us2k119Minor allele frequency- A:0.38NS EA NA MN WA CSA 1182
    rs1885437001,2
    --46282186(+) CATGAC/TGCTGT 4 -- us2k10--------
    rs98426071,2
    C,F,H--46282270(+) tgctaC/Tatcat 4 -- us2k15Minor allele frequency- T:0.00NS EA CSA 420
    rs578719241,2
    C,F--46282278(+) CATTTT/AGCAGT 4 -- us2k16Minor allele frequency- A:0.16NA WA EA 364
    rs126366511,2
    C,F,H--46282391(+) TGAGAT/CCTTAC 4 -- us2k121Minor allele frequency- C:0.41NS EA NA WA CSA 2350
    rs1499739121,2
    --46282405(+) CAGTCA/GAAAAT 4 -- us2k10--------
    rs1442441721,2
    --46282467(+) AGTGAA/GATGTT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCR3 (46205096 - 46308197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876734CNV Gain21882294

    Human Gene Mutation Database (HGMD): CCR3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCR3
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601268    OMIM disorders: --

    Selected diseases for CCR3 (see all 88):    
    About MalaCards
    aids dementia complex    erdheim-chester disease    kimura disease    corneal ulcer
    pulmonary eosinophilia    erythema multiforme    eosinophilic esophagitis    eosinophilia
    bronchitis    lymphomatoid papulosis    pulmonary disease, chronic obstructive    mycosis fungoides
    allergic rhinitis    optic neuritis    toxic epidermal necrolysis    neuritis
    human immunodeficiency virus infectious disease    stevens-johnson syndrome    atopy    gastroesophageal reflux disease

    6 diseases from the University of Copenhagen DISEASES database for CCR3:
    Asthma     Eosinophilia     Hypersensitivity reaction type I disease     Acquired immunodeficiency syndrome
    Atopic dermatitis     Allergic rhinitis

    CCR3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CCR3 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 65.1 28 9573273 (2), 9343175 (2), 17041228 (2), 19218218 (2) (see all 19)
    asthma 63.9 56 17845580 (4), 14561201 (3), 11307756 (2), 11060659 (2) (see all 39)
    inflammation 60.7 46 20144207 (3), 16889234 (2), 12009564 (2), 7622448 (1) (see all 33)
    eosinophilia 54.4 7 17983872 (2), 14698143 (1), 18699933 (1), 10708591 (1) (see all 5)
    aids dementia complex 52.7 1 11115360 (1)
    asthma allergic 45.1 6 15322211 (1), 9893192 (1), 17929797 (1), 19960358 (1) (see all 6)
    airways disease 43.7 4 14698143 (1), 19637977 (1), 17350279 (1)
    dermatitis atopic 42.4 13 10417617 (4), 15948978 (2), 16045735 (1), 14581140 (1) (see all 8)
    allergic rhinitis 42.3 6 20144207 (2), 16623955 (1), 17156343 (1), 10529603 (1) (see all 5)
    allergy 40.2 11 20082620 (2), 14561201 (2), 14561176 (2), 17845580 (1) (see all 7)

    Genetic Association Database (GAD): CCR3
    Human Genome Epidemiology (HuGE) Navigator: CCR3 (45 documents)

    Export disorders for CCR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCR3 gene, integrated from 10 sources (see all 697):
    (articles sorted by number of sources associating them with CCR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New variations of human CC-chemokine receptors CCR3 and CCR4. (PubMed id 11196669)1, 2, 4, 9 Kato H.... Tokunaga K. (Genes Immun. 1999)
    2. Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients. (PubMed id 17983872)1, 4, 9 Lee J.H....Shin H.D. (J. Allergy Clin. Immunol. 2007)
    3. Cloning, expression, and characterization of the human eosinophil eotaxin receptor. (PubMed id 8642344)1, 2, 9 Daugherty B.L.... Springer M.S. (J. Exp. Med. 1996)
    4. The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. (PubMed id 17146638)1, 4, 9 Yang F....Deng H.W. (Hum. Genet. 2007)
    5. Cloning and functional expression of a human eosinophil CC chemokine receptor. (PubMed id 7622448)1, 2, 9 Combadiere C.... Murphy P.M. (J. Biol. Chem. 1995)
    6. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. (PubMed id 17135764)1, 4, 9 Nakamura H....Eboshida A. (Int. Arch. Allergy Immunol. 2007)
    7. The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan. (PubMed id 17845580)1, 4, 9 Wang T.N....Ko Y.C. (Allergy 2007)
    8. Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics. (PubMed id 11307756)1, 4, 9 Fukunaga K....Yamaguchi K. (Eur. Respir. J. 2001)
    9. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. (PubMed id 8676064)1, 2, 9 Ponath P.D.... Mackay C.R. (J. Exp. Med. 1996)
    10. Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy. (PubMed id 20220260)1, 4, 9 Al-Abdulhadi S.A. and Al-Rabia M.W. (Ann Saudi Med 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1232 HGNC: 1604 AceView: CCR3 Ensembl:ENSG00000183625 euGenes: HUgn1232
    ECgene: CCR3 Kegg: 1232 H-InvDB: CCR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCR3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCR3 gene:
    Search GeneIP for patents involving CCR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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