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Aliases for CCR2 Gene

Aliases for CCR2 Gene

  • Chemokine (C-C Motif) Receptor 2 2 3
  • Monocyte Chemoattractant Protein 1 Receptor 3 4
  • CC-CKR-2 3 4
  • MCP-1-R 3 4
  • CMKBR2 3 4
  • CCR-2 3 4
  • Monocyte Chemotactic Protein 1 Receptor 3
  • MCP-1 Receptor 3
  • CD192 Antigen 4
  • C-C CKR-2 4
  • CCR2A 3
  • CCR2B 3
  • CD192 3
  • CKR2A 3
  • CKR2B 3
  • CKR2 3

External Ids for CCR2 Gene

Previous HGNC Symbols for CCR2 Gene

  • CMKBR2

Previous GeneCards Identifiers for CCR2 Gene

  • GC03P045636
  • GC03P046214
  • GC03P9F0042
  • GC03P9K0042

Summaries for CCR2 Gene

Entrez Gene Summary for CCR2 Gene

  • This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for CCR2 Gene

CCR2 (Chemokine (C-C Motif) Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include idiopathic anterior uveitis and cd3zeta deficiency. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR2 Gene

  • Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.

Tocris Summary for CCR2 Gene

  • Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorized into four groups; CC, CXC, CX3C and C (XCL1 and XCL2).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR2 Gene

Genomics for CCR2 Gene

Regulatory Elements for CCR2 Gene

Genomic Location for CCR2 Gene

Chromosome:
3
Start:
46,353,734 bp from pter
End:
46,360,940 bp from pter
Size:
7,207 bases
Orientation:
Plus strand

Genomic View for CCR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR2 Gene

Proteins for CCR2 Gene

  • Protein details for CCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41597-CCR2_HUMAN
    Recommended name:
    C-C chemokine receptor type 2
    Protein Accession:
    P41597
    Secondary Accessions:
    • A0AVQ3
    • B2RMT0
    • Q4VBL2

    Protein attributes for CCR2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41915 Da
    Quaternary structure:
    • Binds to HIV-1 Tat. Interacts with ARRB1.

    Three dimensional structures from OCA and Proteopedia for CCR2 Gene

    Alternative splice isoforms for CCR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCR2 Gene

Proteomics data for CCR2 Gene at MOPED

Post-translational modifications for CCR2 Gene

  • N-glycosylated.
  • Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer.
  • Glycosylation at Asn 14
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCR2 (CCR2)

No data available for DME Specific Peptides for CCR2 Gene

Domains & Families for CCR2 Gene

Gene Families for CCR2 Gene

Graphical View of Domain Structure for InterPro Entry

P41597

UniProtKB/Swiss-Prot:

CCR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR2: view

Function for CCR2 Gene

Molecular function for CCR2 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 2,with high affinity binding for monocyte chemoattractant protein 1 (MCP1),dimerizing in response to MCP1,G protein coupled receptor superfamily,involved in HIV-1 infection and AIDS symptom onset,with a dominant protective effect of the CCR2-64I mutation
UniProtKB/Swiss-Prot Function:
Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
UniProtKB/Swiss-Prot Induction:
Up-regulated by CREB3.

Gene Ontology (GO) - Molecular Function for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 10623817
GO:0016493 C-C chemokine receptor activity IEA --
GO:0031727 CCR2 chemokine receptor binding IDA 15995708
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with CCR2: view
genes like me logo Genes that share phenotypes with CCR2: view

Animal Models for CCR2 Gene

MGI Knock Outs for CCR2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCR2 Gene

Localization for CCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR2 Gene COMPARTMENTS Subcellular localization image for CCR2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15995708
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8146186
GO:0016021 integral component of membrane TAS 8530354
genes like me logo Genes that share ontologies with CCR2: view

Pathways & Interactions for CCR2 Gene

genes like me logo Genes that share pathways with CCR2: view

Pathways by source for CCR2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for CCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling ISS --
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0002827 positive regulation of T-helper 1 type immune response ISS --
GO:0002829 negative regulation of type 2 immune response ISS --
GO:0006874 cellular calcium ion homeostasis ISS --
genes like me logo Genes that share ontologies with CCR2: view

No data available for SIGNOR curated interactions for CCR2 Gene

Drugs & Compounds for CCR2 Gene

(31) Drugs for CCR2 Gene - From: DGIdb, IUPHAR, Tocris, ApexBio, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Maraviroc Approved, Investigational Pharma Antagonist Selective CCR5 antagonist,antiretroviral agent, Selective CCR5 antagonist 0
INCB3284 Investigational Pharma antagonist, Target 0
MLN-1202 Investigational Pharma Target 0
CCX915 Investigational Pharma Target 0
[<sup>125</sup>I]CCL7 (human) Pharma Full agonist, Agonist 0

(5) Additional Compounds for CCR2 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL2
Full agonist, Agonist
vMIP-II
Antagonist
DAPTA
106362-34-9
FC 131
606968-52-9
IT1t dihydrochloride
1092776-63-0
genes like me logo Genes that share compounds with CCR2: view

Transcripts for CCR2 Gene

mRNA/cDNA for CCR2 Gene

(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for CCR2 Gene

GeneLoc Exon Structure for
CCR2
ECgene alternative splicing isoforms for
CCR2

Expression for CCR2 Gene

mRNA expression in normal human tissues for CCR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR2 Gene

This gene is overexpressed in Whole Blood (x25.7) and Spleen (x7.2).

Protein differential expression in normal tissues from HIPED for CCR2 Gene

This gene is overexpressed in Monocytes (35.2) and Peripheral blood mononuclear cells (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR2 Gene



SOURCE GeneReport for Unigene cluster for CCR2 Gene Hs.511794

genes like me logo Genes that share expression patterns with CCR2: view

Protein tissue co-expression partners for CCR2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CCR2 Gene

Orthologs for CCR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCR2 35
  • 84.54 (n)
  • 80 (a)
CCR2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR2 35
  • 80.59 (n)
  • 77.72 (a)
CCR2 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr2 35
  • 80.74 (n)
  • 79.72 (a)
Ccr2 16
Ccr2 36
  • 68 (a)
OneToMany
Ccr5 36
  • 67 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CCR2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCR5 35
  • 66.48 (n)
  • 62 (a)
CCR2 36
  • 53 (a)
ManyToMany
CCR5 36
  • 54 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100329767 35
  • 53.29 (n)
  • 42.07 (a)
Species with no ortholog for CCR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR2 Gene

ENSEMBL:
Gene Tree for CCR2 (if available)
TreeFam:
Gene Tree for CCR2 (if available)

Paralogs for CCR2 Gene

genes like me logo Genes that share paralogs with CCR2: view

Variants for CCR2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCR2 Gene

P41597-CCR2_HUMAN
Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423]

Sequence variations from dbSNP and Humsavar for CCR2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs743660 -- 46,360,527(+) ATCAA(A/G)TTGGC utr-variant-3-prime
rs762788 -- 46,361,073(+) CCCCA(C/T)GCCCT downstream-variant-500B
rs762789 -- 46,361,136(+) CAAGC(A/G)GAGCC downstream-variant-500B
rs762790 -- 46,361,197(+) GCGCC(C/G)TGGTG downstream-variant-500B
rs1042100 -- 46,360,132(+) GAGTT(A/G)CTATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCR2 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294

Variation tolerance for CCR2 Gene

Residual Variation Intolerance Score: 18.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR2 Gene

HapMap Linkage Disequilibrium report
CCR2
Human Gene Mutation Database (HGMD)
CCR2

Disorders for CCR2 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CCR2 Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
idiopathic anterior uveitis
  • anterior uveitis idiopathic
cd3zeta deficiency
purulent labyrinthitis
  • suppurative labyrinthitis
rhinoscleroma
cytomegalovirus retinitis
- elite association
Search CCR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR2

Genetic Association Database (GAD)
CCR2
Human Genome Epidemiology (HuGE) Navigator
CCR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR2
genes like me logo Genes that share disorders with CCR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR2 Gene

Publications for CCR2 Gene

  1. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. (PMID: 8146186) Charo I.F. … Coughlin S.R. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 67
  2. [Association of CCR2 gene rs1799864 polymorphism with hemophagocytic lymphohistiocytosis in children]. (PMID: 25760842) Ou D.Y. … Tang L.J. (Zhongguo Dang Dai Er Ke Za Zhi 2015) 67
  3. Intermediate monocytes contribute to pathologic immune response in Leishmania braziliensis infections. (PMID: 25139016) Passos S. … Scott P. (J. Infect. Dis. 2015) 67
  4. The +190 G/A (rs1799864) polymorphism in the C-C chemokine receptor 2 (CCR2) gene is associated with susceptibility to multiple sclerosis in HLA-DRB1*15:01-negative individuals. (PMID: 25604634) Javor J. … Buc M. (J. Neurol. Sci. 2015) 67
  5. Biased signaling at chemokine receptors. (PMID: 25614627) Corbisier J. … Springael J.Y. (J. Biol. Chem. 2015) 67

Products for CCR2 Gene

Sources for CCR2 Gene

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