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Aliases & Descriptions for CCR2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CC-CKR-2 1 , 2 , 3 CCR-2 3 CCR2A 2 CCR2B 2 CD192 1 , 2 CKR2 1 , 2 CKR2A 2 CKR2B 2 CMKBR2 2 , 3 , 5 FLJ78302 1 , 2 MCP-1-R 1 , 2 , 3 MGC103828 2 MGC111760 2 MGC168006 2
Descriptions C-C CKR-2 3 CD192 antigen 3 MCP-1 receptor 2 Monocyte chemoattractant protein 1 receptor 2 , 3 chemokine (C-C motif) receptor 2 2 monocyte chemotactic protein 1 receptor 2
Search outside databases for aliases for CCR2 genePrevious GC identifers: GC03P045636 GC03P046214 GC03P9F0042 GC03P9K0042
Summaries for CCR2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for CCR2 : This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokinewhich specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved inmonocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in theinflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependentcalcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokinereceptor gene cluster region. Two alternatively spliced transcript variants are expressed by thegene. [provided by RefSeq] UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597 Function : Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing theintracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection
Genomic Location for CCR2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21 CCR2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P046356:
(about GC identifiers )
Start:
46,370,364 bp from pter
End:
46,377,432 bp from pter
Size:
7,069 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000003.10 NT_022517.17 NT_113884.1 Proteins for CCR2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
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Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597 (See
protein sequence )Recommended Name: C-C chemokine receptor type 2 Size : 374 amino acids; 41915 Da
Subunit : Binds to HIV-1 Tat
Subcellular location : Cell membrane; Multi-pass membrane protein
PDB structure from and Proteopedia : 1KAD (3D)
 1KP1 (3D)
 
Secondary accessions : A0AVQ3 B2RMT0Alternative splicing : 2 isoforms : P41597-1 P41597-2
Post-translational modifications:
N-glycosylated1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (4 alternative transcripts):
NP_000638.1 NP_000639.1 NP_001116513.2 NP_001116868.1 ENSEMBL proteins: ENSP00000292301 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for CCR2: Assays for CCR2:
Protein
Domains/ Families for CCR2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P41597 ProtoNet protein and cluster: P41597
2 Blocks protein families : IPB000355 Chemokine receptor signature IPB002237 C-C chemokine receptor type 2 signature UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597 Similarity : Belongs to the G-protein coupled receptor 1 family
Gene Function for CCR2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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                 Browse Origene for 29mer shRNA kit in GFP-retroviral vector Applied Biosystems Silencer ® siRNAs for CCR2 Sigma-Aldrich siRNA for CCR2 Browse shRNA at Sigma-Aldrich Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001123041                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001123041                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001123041  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001123041 UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597 Function : Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing theintracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection
Genatlas biochemistry entry for CCR2 :chemokine CC,beta,receptor 2,with high affinity binding for monocyte chemoattractant protein 1(MCP1),dimerizing in response to MCP1,G protein coupled receptor superfamily,involved in HIV-1infection and AIDS symptom onset,with a dominant protective effect of the CCR2-64I mutation
12 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Ccr2) :4 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for CCR2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for CCR2 5/65 Interacting proteins for CCR2 (ENSP00000292301 3 ) via UniProtKB, MINT, and/or STRING (see all 65
)About this table 5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11
):
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Drugs & Compounds for CCR2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Compounds for CCR2 available from Tocris Bioscience Compound Action
CAS
number RS 504393 Highly selective CCR2 chemokine receptor antagonist [300816-15-3] BMS CCR2 22 High affinity, potent CCR2 antagonist [445479-97-0] RS 102895 hydrochloride CCR2b chemokine receptor antagonist [300815-41-2]
About this table
Transcripts for CCR2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
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                 Browse Origene for 29mer shRNA kit in GFP-retroviral vector Sigma-Aldrich siRNA for CCR2 Browse shRNA at Sigma-Aldrich Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001123041 NM_001123396
REFSEQ mRNAs for CCR2 gene (4 alternative transcripts): NM_000647.4 NM_000648.2 NM_001123041.2 NM_001123396.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001123041 NM_001123396
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001123041                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001123041                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001123041  
Additional cDNA sequence: AK292685.1
2 DOTS entries : DT.412255 DT.95290815
highest scoring ESTs for CCR2 :U03905 D29984 NM_000647 NM_000648 BC095540 BF175316 DA373719 U03882 X95583 BC074751
Unigene Clusters for CCR2: Chemokine (C-C motif) receptor 2 Hs.511794 [show with all ESTs ] , Hs.644637 , Hs.705362 Unigene Representative Sequences: NM_001123041 , U03882 , AK292685 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for CCR2 ExUns: 1a · 1b ^ 2 ^ 3a · 3b SP1 :           SP2 :     -      
About this scheme ECgene alternative splicing isoforms for CCR2 1 Ensembl transcript including schematic representation : ENST00000292301
Expression for CCR2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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CCR2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for CCR2 1 / 2 / 3
7 probe-sets matching CCR2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGCTCAGGGASOURCE GeneReport for Unigene clusters: Hs.511794 Hs.644637 Hs.705362 Expression variation in blood from EXPOLDB for CCR2
Orthologs for CCR2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for CCR2 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for CCR2 ENSEMBL Gene Tree for CCR2 Paralogs for CCR2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for CCR2 gene CCRL2 2 CCR5 2 ENSG00000215782 2 ENSG00000215778 2 CCR4 2 CCR1 2 CCR3 2 ENSG00000215775 2
SNPs/Variants for CCR2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597 Polymorphism : Variations in CCR2 are associated with relative resistance to immunodeficiency virustype 1 (resistance to HIV-1) [MIM:609423]
The following additional 6 SNP(s) have been
found in Applied Biosystems data source:(Click
for
Applied Biosystems TaqMan ® Genotyping Assay ) HapMap Linkage Disequilibrium images for CCR2 (up to first 250kb)
Disorders & Mutations for CCR2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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and/or TGDB .)
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OMIM: 601267 Human Gene Mutation Database : CCR2 Genetic Association Database: CCR2 Human Genome Epidemiology Navigator: CCR2 (176 documents)
Medical News for CCR2 (Possibly Related Articles in
Doctor's Guide )
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Publications for CCR2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/257 PubMed articles for CCR2 gene (see all 257
): Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. (PubMed id 8146186) 2, 3, 4 Charo I.F....Coughlin S.R. (1994) Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. (PubMed id 16323127) 3, 6 Shrestha S....Smith M.W. (2006) Examination of genetic effects of polymorphisms in the MCP-1 and CCR2 genes on MI in the Icelandic population. (PubMed id 16356504) 3, 6 Bjarnadottir K....Gudnason V. (2006) Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women. (PubMed id 16055130) 3, 6 Pai J.K....Rimm E.B. (2006) The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997) 3, 4 Muzny D.M....Gibbs R.A. (2006) CCR2-64I and CXCL12 3'A alleles confer a favorable prognosis to AIDS patients undergoing HAART therapy. (PubMed id 16286054) 3, 6 Passam A.M....Spandidos D.A. (2005) CCR5, RANTES and CX3CR1 polymorphisms: possible genetic links with acute heart rejection. (PubMed id 16314800) 3, 6 Simeoni E....Fleury S. (2005) The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. (PubMed id 15863470) 3, 6 Goulding C....Kelleher D. (2005) [Effect of CCR5delta32, CCR5m303, CCR2-64I and SDF1-3'A gene polymorphism on the prognosis of Chinese HIV-1 carriers] (PubMed id 16261210) 3, 6 Wang X.H....Jin L. (2005) The frequency of CCR5Delta32 and CCR2-64I in southern Iranian normal population. (PubMed id 15585333) 3, 6 Gharagozloo M....Ghaderi A. (2005)
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Genome Databases showing CCR2
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Other Databases showing CCR2
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--
Specialized Databases showing CCR2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for CCR2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for CCR2:
Recombinant Proteins (CCR2 ) Antibodies (CCR2 )
Tocris compounds for CCR2
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