Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCR2 Gene

protein-coding   GIFtS: 64
GCID: GC03P046356

chemokine (C-C motif) receptor 2


(Previous symbol: CMKBR2)
 Explore 84 diseases affiliated with
CCR2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCR2    

Aliases
for CCR2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chemokine (C-C Motif) Receptor 21 2     CCR2A2
CMKBR21 2 3 5     CCR2B2
CC-CKR-21 2 3     CKR2A2
MCP-1-R1 2 3     CKR2B2
CD1921 2     C-C Chemokine Receptor Type 22
CKR21 2     MCP-1 Receptor2
Monocyte Chemoattractant Protein 1 Receptor2 3     Monocyte Chemotactic Protein 1 Receptor2
CCR-22 3     C-C CKR-23
FLJ783021     CD192 Antigen3

External Ids:    HGNC: 16031   Entrez Gene: 7292302   Ensembl: ENSG000001218077   OMIM: 6012675   UniProtKB: P415973   

Export aliases for CCR2 gene to outside databases

Previous GC identifers: GC03P045636 GC03P046214 GC03P9F0042 GC03P9K0042


Summaries
for CCR2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCR2:
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically
mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory
diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by
this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in
the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
(provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597
Function: Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular
calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection

summary for CCR2:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.




Genomic Views
for CCR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCR2 gene promoter:
         ISGF-3   GATA-3   AP-1   SREBP-1c   ATF-2   SREBP-1b   GATA-1   SREBP-1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CCR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P046356:  view genomic region     (about GC identifiers)

Start:
 46,395,225 bp from pter      End:
 46,402,419 bp from pter
Size:
 7,195 bases      Orientation:
 plus strand

Proteins
for CCR2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597 (See protein sequence)
Recommended Name: C-C chemokine receptor type 2  
Size: 374 amino acids; 41915 Da
Subunit: Binds to HIV-1 Tat. Interacts with ARRB1
Subcellular location: Cell membrane; Multi-pass membrane protein
2 PDB 3D structures from and Proteopedia for CCR2:
1KAD (3D)        1KP1 (3D)    
Secondary accessions: A0AVQ3 B2RMT0 Q4VBL2
Alternative splicing: 2 isoforms:  P41597-1   P41597-2   

Explore the universe of human proteins at neXtProt for CCR2: NX_P41597

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41597

    • CCR2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116513.2  NP_001116868.1  

    ENSEMBL proteins: 
     ENSP00000399285   ENSP00000396736   ENSP00000383681   ENSP00000292301  
    Reactome Protein details: P41597
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CCR2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): CCR2
    OriGene Custom Protein Services for CCR2 
    GenScript Custom Purified and Recombinant Proteins Services for CCR2
    Novus Biologicals CCR2 Proteins
    Novus Biologicals CCR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CCR2

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm IDA15995708
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8146186


    CCR2 for ontologies           About GeneDecksing



    CCR2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCR2
    Cell Signaling Technology (CST) Antibodies for CCR2 
    OriGene Antibodies: CCR2
    OriGene Custom Antibody Services for CCR2 
    GenScript Custom Superior Antibodies Services for CCR2
    Novus Biologicals CCR2 Antibodies
    Abcam antibodies for CCR2 
    Uscn Antibodies for CCR2
    ThermoFisher Antibodies for CCR2

    Assay Products for CCR2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCR2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCR2

    Protein Domains /
    Families
    for CCR2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCR2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002237 Chemokine_CCR2
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P41597

    ProtoNet protein and cluster: P41597

    2 Blocks protein families:
    IPB000355 Chemokine receptor signature
    IPB002237 C-C chemokine receptor type 2 signature


    UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for CCR2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597
    Function: Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular
    calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection
    Induction: Up-regulated by CREB3

         Genatlas biochemistry entry for CCR2:
    chemokine CC,beta,receptor 2,with high affinity binding for monocyte chemoattractant protein 1 (MCP1),dimerizing in
    response to MCP1,G protein coupled receptor superfamily,involved in HIV-1 infection and AIDS symptom onset,with a
    dominant protective effect of the CCR2-64I mutation

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): CCR2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCR2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR2:
    hsa-miR-125a-5p hsa-miR-544b hsa-miR-612 hsa-miR-670 hsa-miR-125b hsa-miR-1285 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: CCR2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCR2 (see all 4)
    OriGene shRNA RFP: CCR2
    OriGene siRNA: CCR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCR2

    Clone
    Products:             		EMD Millipore Clones for the Expression of CCR2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CCR2 (NM_001123041)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CCR2
    Search LifeMap BioReagents cell lines for CCR2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR2

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004950chemokine receptor activity TAS10623817
    GO:0016493C-C chemokine receptor activity IEA--
    GO:0031727CCR2 chemokine receptor binding IDA15995708
    GO:0035715chemokine (C-C motif) ligand 2 binding ----
    GO:0035716chemokine (C-C motif) ligand 12 binding ----


    CCR2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CCR2: Ccr2tm1Brv Ccr2tm1Mae Ccr2tm1Ifc
         15/19 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Ccr2) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     nervous system  no phenotypic analysis  other  pigmentation  renal/urinary system 

    CCR2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCR2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    2Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    3Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    5Beta defensins
    		Beta defensins1.00
    		Defensins0.80

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for CCR2
        A-beta Uptake & Degradation

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR2 (see all 9)
        Chemokine Signaling
    MSP-RON Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for CCR2
        Lymphocyte Signaling

    5/12        Reactome Pathways for CCR2 (see all 12)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)


    2         Kegg Pathways  (Kegg details for CCR2):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for CCR2 (P415973 ENSP000002923014) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL16O154673, ENSP000002932754I2D: score=1 STRING: ENSP00000293275
    CCL2P135003, ENSP000002258314I2D: score=1 STRING: ENSP00000225831
    CCL7P800983, ENSP000002003074I2D: score=1 STRING: ENSP00000200307
    CCR5P516813, ENSP000002923034I2D: score=1 STRING: ENSP00000292303
    CCL8P800753I2D: score=1 
    About this table

    Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia ----
    GO:0001974blood vessel remodeling ISS--
    GO:0002407dendritic cell chemotaxis TAS16621978
    GO:0002437inflammatory response to antigenic stimulus ----
    GO:0002827positive regulation of T-helper 1 type immune response ISS--


    CCR2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCR2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CCR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    INCB 3284Selective CCR2 antagonist[887401-93-6]
    BMS CCR2 22 High affinity, potent CCR2 antagonist [445479-97-0]
    RS 102895 hydrochlorideCCR2b chemokine receptor antagonist[300815-41-2]

    1 HMDB Compound for CCR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CCR2 

    Transcripts
    for CCR2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCR2 gene (2 alternative transcripts): 
    NM_001123041.2  NM_001123396.1  

    Unigene Clusters for CCR2:

    Chemokine (C-C motif) receptor 2
    Hs.511794  [show with all ESTs], Hs.705362
    Unigene Representative Sequences: NM_001123041, AK292685
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445132(uc003cpm.4) ENST00000465202 ENST00000421659 ENST00000400888
    ENST00000292301(uc003cpn.4)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): CCR2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCR2
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR2:
    hsa-miR-125a-5p hsa-miR-544b hsa-miR-612 hsa-miR-670 hsa-miR-125b hsa-miR-1285 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: CCR2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCR2 (see all 4)
    OriGene shRNA RFP: CCR2
    OriGene siRNA: CCR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CCR2 (NM_001123041)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR2

    Additional cDNA sequence: AK292685.1 

    2 DOTS entries:

    DT.412255  DT.95290815 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCR2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for CCR2

    Expression
    for CCR2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGTTTAATCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCR2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Bone marrow-derived mesenchymal stem cells (Stempeucel) (Adult Stem / Progenitor Cell)Bone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CCR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCR2

    SOURCE GeneReport for Unigene clusters: Hs.511794 Hs.705362
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCR2 (see all 13): 
              HIV Host Response in human mouse rat
              Fibrosis in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR2

    Orthologs
    for CCR2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCR2 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCR21 chemokine (C-C motif) receptor 2 63.71(n)
    58.29(a)    		   420696  NM_001045835.1  NP_001039300.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 57(a)
    53(a)
    		 many ↔ many
    many ↔ many
    		 GL343324.1(448159-449136)
    GL343324.1(443935-445008)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003297671 c-C chemokine receptor type 5-like 54.74(n)
    44.53(a)    		   100329767  XM_002664797.2  XP_002664843.2 


    ENSEMBL Gene Tree for CCR2 (if available)
    TreeFam Gene Tree for CCR2 (if available) 

    Paralogs
    for CCR2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCR2 gene
    CCR62  CCR52  CXCR62  CXCR32  XCR12  CCR92  CCBP22  CCRL22  
    CCR72  CX3CR12  CCR82  CXCR22  CCRL12  CCR42  CCR12  CXCR12  
    CXCR52  CCR102  CCR32  CXCR42  
    18/38 SIMAP similar genes for CCR2 using alignment to 6 protein entries:     CCR2_HUMAN (see all proteins) (see all similar genes):
    CCR5    CCR-5    CCR1    CCR3    CCR4    CCR8
    CXCR2    CCR7    CCRL2    BDKRB1    SSTR5    CCBP2
    CCR6    CCR9    CXCR6    IL8RB    CX3CR1    CXCR1

    CCR2 for paralogs           About GeneDecksing



    Genomic Variants
    for CCR2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597
    Polymorphism: Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance
    to HIV-1) [MIM:609423]


    10/177 NCBI SNPs in CCR2 are shown (see all 177)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs17998641,2
    		C,F,pathogenic86092476(+) TGGTCG/ATCCTC 4 /I /V mis127Minor allele frequency- A:0.14MN NS NA CSA EA WA 3454
    rs1822787681,2
    		--46393401(+) CAGAAA/GTGGCA 2 -- us2k10--------
    rs39183541,2
    		C,F,--46393463(+) CAGAGA/GTATGC 2 -- us2k118Minor allele frequency- G:0.05NS NA EA 2204
    rs1458316411,2
    		--46393528(+) CTGAAC/TAGGCA 2 -- us2k10--------
    rs1417662961,2
    		--46393543(+) GCTGTC/GTTCCA 2 -- us2k10--------
    rs354241131,2
    		C--46393933(+) ATAACACA/-ACAAC 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs39183571,2
    		C,F,H,--46393970(+) AAAGCC/AAACTT 2 -- us2k122Minor allele frequency- A:0.18NS EA NA WA 3448
    rs1932549371,2
    		--46394124(+) CCCTGC/TTCTAG 2 -- us2k10--------
    rs1430474151,2
    		--46394193(+) TGGGAA/GATGGA 2 -- us2k10--------
    rs1834105431,2
    		--46394223(+) TCCACA/TGCATG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCR2 (46395225 - 46402419 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCR2: --
    Human Gene Mutation Database (HGMD): CCR2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR2

    Disorders / Diseases
    for CCR2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCR2 for disorders           About GeneDecksing

    OMIM gene information: 601267    OMIM disorders: --

    20/84 diseases for CCR2 (see all 84):    About MalaCards
    rheumatoid arthritis    hiv infection, susceptibility/resistance to    diffuse large b-cell lymphoma    hematopoiesis
    arthritis    age related macular degeneration    human immunodeficiency virus infectious disease    b-cell lymphomas
    type 1 diabetes mellitus    hiv-1, resistance to    anterior uveitis    macular degeneration
    myasthenia gravis    arterial calcification    acquired immunodeficiency syndrome    systemic lupus erythematosus
    lupus erythematosus    coronary heart disease    aggressive periodontitis    diabetes mellitus

    4 diseases from the University of Copenhagen DISEASES database for CCR2:
    Atherosclerosis     Human immunodeficiency virus infectious disease     Multiple sclerosis     Lung disease
    Genetic Association Database (GAD): CCR2
    Human Genome Epidemiology (HuGE) Navigator: CCR2 (205 documents)

    Export disorders for CCR2 gene to outside databases

    Publications
    for CCR2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCR2 gene, integrated from 9 sources (see all 372):
    (articles sorted by number of sources associating them with CCR2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. (PubMed id 8146186)1, 2, 3 Charo I.F....Coughlin S.R. (1994)
    2. Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. (PubMed id 18587271)1, 2 Sung H.J....Ko J. (2008)
    3. Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. (PubMed id 16323127)1, 4 Shrestha S....Smith M.W. (2006)
    4. Examination of genetic effects of polymorphisms in the MCP-1 and CCR2 genes on MI in the Icelandic population. (PubMed id 16356504)1, 4 Bjarnadottir K....Gudnason V. (2006)
    5. Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women. (PubMed id 16055130)1, 4 Pai J.K....Rimm E.B. (2006)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    7. CCR2-64I and CXCL12 3'A alleles confer a favorable prognosis to AIDS patients undergoing HAART therapy. (PubMed id 16286054)1, 4 Passam A.M....Spandidos D.A. (2005)
    8. CCR5, RANTES and CX3CR1 polymorphisms: possible genetic links with acute heart rejection. (PubMed id 16314800)1, 4 Simeoni E....Fleury S. (2005)
    9. The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. (PubMed id 15863470)1, 4 Goulding C....Kelleher D. (2005)
    10. [Effect of CCR5delta32, CCR5m303, CCR2-64I and SDF1-3'A gene polymorphism on the prognosis of Chinese HIV-1 carriers] (PubMed id 16261210)1, 4 Wang X.H....Jin L. (2005)

    External Searches for CCR2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCR2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 729230 HGNC: 1603 Ensembl:ENSG00000121807 euGenes: HUgn729230 ECgene: CCR2 Kegg: 729230
    H-InvDB: CCR2

    Other Databases showing CCR2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCR2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCR2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors
    SeattleSNPshttp://pga.gs.washington.edu/data/ccr2/

    Intellectual Property
    for CCR2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCR2 gene:
    Search GeneIP for patents involving CCR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CCR2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant CCR2 Protein
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore Clones for the Expression of CCR2
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CCR2 (CCR2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for CCR2   OriGene shRNA RFP for CCR2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCR2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCR2  
     OriGene Protein Over-expression Lysate for CCR2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CCR2   OriGene 3'-UTR Clone for CCR2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCR2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCR2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCR2   OriGene Custom Protein Services for CCR2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCR2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCR2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR2
     GenScript Custom Purified and Recombinant Proteins Services for CCR2 GenScript cDNA clones with any tag delivered in your preferred vector for CCR2
     GenScript Custom Assay Services for CCR2 GenScript Custom Superior Antibodies Services for CCR2
     GenScript Custom overexpressing Cell Line Services for CCR2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CCR2 

     Regulatory tfbs in CCR2 promoter
     Search Chromatin IP Primers for CCR2
     RT2 qPCR Primer Assay in human, mouse, rat CCR2
     GNC Network for CCR2
     SABiosciences PCR Arrays including human, mouse, rat CCR2
     Tocris compounds for CCR2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCR2 antibodies
     CCR2 proteins
     CCR2 lysates
     Antibodies for CCR2
     See all of Abcam's Antibodies, Kits and Proteins for CCR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CCR2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CCR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR2
     SwitchGear 3'UTR luciferase reporter plasmids for CCR2
     SwitchGear Promoter luciferase reporter plasmids for CCR2
     ThermoFisher Antibodies for CCR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CCR2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4