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CCR2 Gene

protein-coding   GIFtS: 67
GCID: GC03P046356

Chemokine (C-C Motif) Receptor 2


(Previous symbol: CMKBR2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Receptor 21 2     CKR22
CMKBR21 2 3 5     CKR2A2
Monocyte Chemoattractant Protein 1 Receptor2 3     CKR2B2
CC-CKR-22 3     C-C Chemokine Receptor Type 22
CCR-22 3     MCP-1 Receptor2
MCP-1-R2 3     Monocyte Chemotactic Protein 1 Receptor2
CCR2A2     C-C CKR-23
CCR2B2     CD192 Antigen3
CD1922     

External Ids:    HGNC: 16031   Entrez Gene: 7292302   Ensembl: ENSG000001218077   OMIM: 6012675   UniProtKB: P415973   

Export aliases for CCR2 gene to outside databases

Previous GC identifers: GC03P045636 GC03P046214 GC03P9F0042 GC03P9K0042


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCR2 Gene:
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which
specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte
infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response
against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition
of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively
spliced transcript variants are expressed by the gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for CCR2 Gene:
CCR2 (chemokine (C-C motif) receptor 2) is a protein-coding gene. Diseases associated with CCR2 include idiopathic anterior uveitis, and anterior uveitis. GO annotations related to this gene include C-C chemokine receptor activity and protein homodimerization activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597
Function: Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular
calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection

summary for CCR2 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCR2 gene promoter:
         ISGF-3   GATA-3   AP-1   SREBP-1c   ATF-2   SREBP-1b   GATA-1   SREBP-1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCR2 promoter sequence
   Search Chromatin IP Primers for CCR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CCR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P046356:  view genomic region     (about GC identifiers)

Start:
46,395,225 bp from pter      End:
46,402,419 bp from pter
Size:
7,195 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597 (See protein sequence)
Recommended Name: C-C chemokine receptor type 2  
Size: 374 amino acids; 41915 Da
Subunit: Binds to HIV-1 Tat. Interacts with ARRB1
2 PDB 3D structures from and Proteopedia for CCR2:
1KAD (3D)        1KP1 (3D)    
Secondary accessions: A0AVQ3 B2RMT0 Q4VBL2
Alternative splicing: 2 isoforms:  P41597-1   P41597-2   

Explore the universe of human proteins at neXtProt for CCR2: NX_P41597

Explore proteomics data for CCR2 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form.
    Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer1
  • Glycosylation2 at Asn14
  • Modification sites at PhosphoSitePlus

  • See CCR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116513.2  NP_001116868.1  

    ENSEMBL proteins: 
     ENSP00000399285   ENSP00000396736   ENSP00000383681   ENSP00000292301  
    Reactome Protein details: P41597

    CCR2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CCR2 Protein
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    OriGene Protein Over-expression Lysate for CCR2
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    OriGene Custom Protein Services for CCR2
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    Novus Biologicals CCR2 Proteins
    Novus Biologicals CCR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCR2

    CCR2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CCR2

    CCR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CCR2
    Cloud-Clone Corp. CLIAs for CCR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR2
    Chemokine receptors

    4 InterPro protein domains:
     IPR002237 Chemokine_CCR2
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P41597

    ProtoNet protein and cluster: P41597

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB002237 C-C chemokine receptor type 2 signature


    UniProtKB/Swiss-Prot: CCR2_HUMAN, P41597
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CCR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR2_HUMAN, P41597
    Function: Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular
    calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection
    Induction: Up-regulated by CREB3

         Genatlas biochemistry entry for CCR2:
    chemokine CC,beta,receptor 2,with high affinity binding for monocyte chemoattractant protein 1 (MCP1),dimerizing
    in response to MCP1,G protein coupled receptor superfamily,involved in HIV-1 infection and AIDS symptom
    onset,with a dominant protective effect of the CCR2-64I mutation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS10623817
    GO:0016493C-C chemokine receptor activity IEA--
    GO:0031727CCR2 chemokine receptor binding IDA15995708
    GO:0042803protein homodimerization activity ISS--
         
    CCR2 for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ccr2) (see all 19):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     nervous system  no phenotypic analysis  other  pigmentation  renal/urinary system 

    CCR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CCR2: Ccr2tm1Brv Ccr2tm1Mae Ccr2tm1Ifc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCR2:
    hsa-mir-335-5p (MIRT018230), hsa-mir-744-3p (MIRT037379)

    Block miRNA regulation of human, mouse, rat CCR2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CCR2:
    hsa-miR-125a-5p hsa-miR-544b hsa-miR-612 hsa-miR-670 hsa-miR-125b hsa-miR-1285 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidCCR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCR2
    Predesigned siRNA for gene silencing in human, mouse, rat CCR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCR2

    Clone
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    OriGene ORF clones in mouse, rat for CCR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCR2 (NM_001123041)
    Sino Biological Human cDNA Clone for CCR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCR2_HUMAN, P41597: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton2
    extracellular2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15995708
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8146186
    GO:0016021integral component of membrane TAS8530354

    CCR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCR2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    2PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CCR2
        A-beta Uptake & Degradation
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR2 (see all 9)
        Chemokine Signaling
    MSP-RON Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for CCR2
        Lymphocyte Signaling

    1 BioSystems Pathway for CCR2
        Spinal Cord Injury


    3 Reactome Pathways for CCR2
        Chemokine receptors bind chemokines
    G alpha (i) signalling events
    Beta defensins


    2 Kegg Pathways  (Kegg details for CCR2):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR2 (see all 13): 
              HIV Host Response in human mouse rat
              Fibrosis in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCR2 (P415973 ENSP000002923014) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL16O154673, ENSP000002932754I2D: score=1 STRING: ENSP00000293275
    CCL2P135003, ENSP000002258314I2D: score=1 STRING: ENSP00000225831
    CCL7P800983, ENSP000002003074I2D: score=1 STRING: ENSP00000200307
    CCR5P516813, ENSP000002923034I2D: score=1 STRING: ENSP00000292303
    CCL8P800753I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001974blood vessel remodeling ISS--
    GO:0002407dendritic cell chemotaxis TAS16621978
    GO:0002827positive regulation of T-helper 1 type immune response ISS--
    GO:0002829negative regulation of type 2 immune response ISS--
    GO:0006874cellular calcium ion homeostasis ISS--

    CCR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for CCR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    1 HMDB Compound for CCR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for CCR2 (CCR2) (see all 21)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCL2
    AgonistFull agonist9.3 - 10.29346309 12554737 10770925 15207250 9276730
    vMIP-II
    AntagonistAntagonist9.19287217
    MC148R
    AntagonistAntagonist8.89600978
    CCL13
    AgonistFull agonist8.6 - 8.79276730 12554737
    CCL7
    AgonistFull agonist8.4 - 8.79346309 9276730 12554737
    CCL8
    AgonistFull agonist8.612554737
    RS-136270
    AntagonistAntagonist8.510770925
    CCL26
    AntagonistAntagonist8.515207250
    HIV-Tat
    AgonistFull agonist8.39789057
    GSK Compound 34
    AntagonistAntagonist7.6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCR2 gene (2 alternative transcripts): 
    NM_001123041.2  NM_001123396.1  

    Unigene Cluster for CCR2:

    Chemokine (C-C motif) receptor 2
    Hs.511794  [show with all ESTs]
    Unigene Representative Sequence: NM_001123041
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445132(uc003cpm.4) ENST00000465202 ENST00000421659 ENST00000400888
    ENST00000292301(uc003cpn.4)
    miRNA
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    Block miRNA regulation of human, mouse, rat CCR2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CCR2:
    hsa-miR-125a-5p hsa-miR-544b hsa-miR-612 hsa-miR-670 hsa-miR-125b hsa-miR-1285 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidCCR2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCR2 (NM_001123041)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCR2
      QuantiTect SYBR Green Assays in human, mouse, rat CCR2
      QuantiFast Probe-based Assays in human, mouse, rat CCR2

    Additional mRNA sequence: 

    AK292920.1 BC074751.2 BC095540.1 BC126452.1 BC136396.1 D29984.1 U03882.1 U03905.1 
    X95583.1 

    2 DOTS entries:

    DT.412255  DT.95290815 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCR2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for CCR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTTTAATCA
    CCR2 Expression
    About this image


    CCR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
    CCR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511794
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR2 (see all 13): 
              HIV Host Response in human mouse rat
              Fibrosis in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CCR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCR2
    QuantiTect SYBR Green Assays in human, mouse, rat CCR2
    QuantiFast Probe-based Assays in human, mouse, rat CCR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CCR2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr21 , 5 chemokine (C-C motif) receptor 21, 5 80.74(n)1
    79.72(a)1
      9 (75.05 cM)5
    127721  NM_009915.21  NP_034045.11 
     1241019505 
    chicken
    (Gallus gallus)
    Aves CCR51 chemokine (C-C motif) receptor 5 66.48(n)
    62(a)
      420695  NM_001271141.1  NP_001258070.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    57(a)
    54(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343324.1(448159-449136)
    GL343324.1(443935-445008)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003297671 c-C chemokine receptor type 5-like 53.29(n)
    42.07(a)
      100329767  XM_002664797.3  XP_002664843.3 


    ENSEMBL Gene Tree for CCR2 (if available)
    TreeFam Gene Tree for CCR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCR2 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CCR2 using alignment to 6 protein entries:     CCR2_HUMAN (see all proteins) (see all similar genes):
    CCR-5    CCR5    CCR1    CCR3    CCR4    CCR8
    CXCR2    CCR7    ACKR2    CCR9    CCRL2    CX3CR1
    CCBP2    CCR6    CXCR6    IL8RB    CMKLR1    CXCR1

    CCR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CCR2_HUMAN, P41597: Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1
    (resistance to HIV-1) [MIM:609423]


    Selected SNPs for CCR2 (see all 247)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17998641,2,,4
    C,Fpathogenic146329767(+) TGGTCG/ATCCTC 4 /I /V mis127Minor allele frequency- A:0.14MN NS NA CSA EA WA 3454
    rs1822787681,2
    --46323961(+) CAGAAA/GTGGCA 2 -- us2k10--------
    rs39183541,2
    C,F--46324023(+) CAGAGA/GTATGC 2 -- us2k118Minor allele frequency- G:0.05NS NA EA 2204
    rs1458316411,2
    --46324088(+) CTGAAC/TAGGCA 2 -- us2k10--------
    rs1417662961,2
    --46324103(+) GCTGTC/GTTCCA 2 -- us2k10--------
    rs39183551,2
    C,F--46324387(+) agaggA/Tttgct 2 -- us2k1 tfbs32Minor allele frequency- T:0.03NS 90
    rs354241131,2
    C--46324493(+) ATAACACA/-ACAAC 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs39183561,2
    C,F--46324508(+) AACAA-/CAACAACA 4 -- us2k1 cds12Minor allele frequency- CAA:0.35NS 92
    rs39183571,2
    C,F,H--46324530(+) AAAGCC/AAACTT 2 -- us2k122Minor allele frequency- A:0.18NS EA NA WA 3448
    rs39183691,2
    C,F--46324570(+) CCCTGA/GGCATT 2 -- us2k12Minor allele frequency- G:0.01NS 94

    HapMap Linkage Disequilibrium report for CCR2 (46395225 - 46402419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876734CNV Gain21882294

    Human Gene Mutation Database (HGMD): CCR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601267    OMIM disorders: --

    Selected diseases for CCR2 (see all 94):    
    About MalaCards
    idiopathic anterior uveitis    anterior uveitis    hiv infection, susceptibility/    secondary progressive multiple sclerosis
    cytomegalovirus retinitis    neuroretinitis    hiv/aids    pneumoconiosis
    uveitis    transient cerebral ischemia    aggressive periodontitis    human immunodeficiency virus infectious disease
    rheumatoid arthritis    acquired immunodeficiency syndrome    interstitial lung disease    arthritis
    venous thromboembolism    addison's disease    hiv-1    age related macular degeneration

    4 diseases from the University of Copenhagen DISEASES database for CCR2:
    Acquired immunodeficiency syndrome     Atherosclerosis     Multiple sclerosis     Lung disease

    CCR2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCR2
    Human Genome Epidemiology (HuGE) Navigator: CCR2 (205 documents)

    Export disorders for CCR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCR2 gene, integrated from 10 sources (see all 398):
    (articles sorted by number of sources associating them with CCR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. (PubMed id 8146186)1, 2, 3 Charo I.F....Coughlin S.R. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1). (PubMed id 23408426)1, 2 Tan J.H....Stone M.J. (J. Biol. Chem. 2013)
    3. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    4. Chemokine polymorphisms and lymphoma: a pooled analysis. (PubMed id 20038229)1, 4 Bracci P.M....Wiencke J.K. (amp 2010)
    5. CCR2-64I allele is associated with the progression of AIDS in a Han Chinese population. (PubMed id 19669591)1, 4 Xu L....Fu S. (Mol. Biol. Rep. 2010)
    6. MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders. (PubMed id 19055601)1, 4 Holla L.I....Petrek M. (Int. J. Immunogenet. 2009)
    7. Impact of chemokine receptor CCR2 and CCR5 gene polymorphism on allograft outcome in North Indian renal transplant recipients. (PubMed id 19037908)1, 4 Singh R....Mittal R.D. (Scand. J. Immunol. 2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    9. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. (PubMed id 19263529)1, 4 Zee R.Y....Glynn R.J. ( international journal of clinical chemistry 2009)
    10. Sequence variants of chemokine receptor genes and susceptibility to HIV-1 infection. (PubMed id 19433914)1, 4 Parczewski M....Ciechanowicz A. (J. Appl. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 729230 HGNC: 1603 Ensembl:ENSG00000121807 euGenes: HUgn729230 ECgene: CCR2 Kegg: 729230
    H-InvDB: CCR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCR2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors
    SeattleSNPshttp://pga.gs.washington.edu/data/ccr2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCR2 gene:
    Search GeneIP for patents involving CCR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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