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Aliases for CCR10 Gene

Aliases for CCR10 Gene

  • C-C Motif Chemokine Receptor 10 2 3
  • Chemokine (C-C Motif) Receptor 10 2 3 5
  • G Protein-Coupled Receptor 2 2 3
  • G-Protein Coupled Receptor 2 3 4
  • C-C CKR-10 3 4
  • CC-CKR-10 3 4
  • CCR-10 3 4
  • GPR2 3 4
  • CC Chemokine Receptor 10 3

External Ids for CCR10 Gene

Previous HGNC Symbols for CCR10 Gene

  • GPR2

Previous GeneCards Identifiers for CCR10 Gene

  • GC17M038086
  • GC17M040830
  • GC17M036600

Summaries for CCR10 Gene

Entrez Gene Summary for CCR10 Gene

  • Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CCR10 Gene

CCR10 (C-C Motif Chemokine Receptor 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity.

UniProtKB/Swiss-Prot for CCR10 Gene

  • Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Gene Wiki entry for CCR10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR10 Gene

Genomics for CCR10 Gene

Regulatory Elements for CCR10 Gene

Promoters for CCR10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCR10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCR10 Gene

Chromosome:
17
Start:
42,678,889 bp from pter
End:
42,683,917 bp from pter
Size:
5,029 bases
Orientation:
Minus strand

Genomic View for CCR10 Gene

Genes around CCR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR10 Gene

Proteins for CCR10 Gene

  • Protein details for CCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46092-CCR10_HUMAN
    Recommended name:
    C-C chemokine receptor type 10
    Protein Accession:
    P46092
    Secondary Accessions:
    • Q4V749
    • Q6T7X2
    • Q9NZG2

    Protein attributes for CCR10 Gene

    Size:
    362 amino acids
    Molecular mass:
    38416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR10 Gene

Proteomics data for CCR10 Gene at MOPED

Post-translational modifications for CCR10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCR10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCR10 Gene

Domains & Families for CCR10 Gene

Gene Families for CCR10 Gene

Suggested Antigen Peptide Sequences for CCR10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46092

UniProtKB/Swiss-Prot:

CCR10_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR10: view

Function for CCR10 Gene

Molecular function for CCR10 Gene

UniProtKB/Swiss-Prot Function:
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
genes like me logo Genes that share phenotypes with CCR10: view

Animal Models for CCR10 Gene

MGI Knock Outs for CCR10:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCR10 Gene

Localization for CCR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR10 Gene COMPARTMENTS Subcellular localization image for CCR10 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CCR10: view

Pathways & Interactions for CCR10 Gene

genes like me logo Genes that share pathways with CCR10: view

Gene Ontology (GO) - Biological Process for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with CCR10: view

No data available for SIGNOR curated interactions for CCR10 Gene

Drugs & Compounds for CCR10 Gene

(3) Drugs for CCR10 Gene - From: IUPHAR, DGIdb, Novoseek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL27 Pharma Full agonist, Agonist 0
CCL28 Pharma Full agonist, Agonist 0
calcium Nutra 0
genes like me logo Genes that share compounds with CCR10: view

Transcripts for CCR10 Gene

mRNA/cDNA for CCR10 Gene

Unigene Clusters for CCR10 Gene

Chemokine (C-C motif) receptor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCR10 Gene

No ASD Table

Relevant External Links for CCR10 Gene

GeneLoc Exon Structure for
CCR10
ECgene alternative splicing isoforms for
CCR10

Expression for CCR10 Gene

mRNA expression in normal human tissues for CCR10 Gene

mRNA differential expression in normal tissues according to GTEx for CCR10 Gene

This gene is overexpressed in Pituitary (x5.1).

SOURCE GeneReport for Unigene cluster for CCR10 Gene Hs.744542

mRNA Expression by UniProt/SwissProt for CCR10 Gene

P46092-CCR10_HUMAN
Tissue specificity: Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.
genes like me logo Genes that share expression patterns with CCR10: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCR10 Gene

Orthologs for CCR10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR10 36
  • 100 (a)
OneToOne
CCR10 35
  • 99.36 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CCR10 36
  • 92 (a)
OneToOne
CCR10 35
  • 88.27 (n)
  • 91.97 (a)
dog
(Canis familiaris)
Mammalia CCR10 35
  • 88.92 (n)
  • 92.24 (a)
CCR10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr10 16
Ccr10 36
  • 88 (a)
OneToOne
Ccr10 35
  • 84.99 (n)
  • 88.12 (a)
oppossum
(Monodelphis domestica)
Mammalia CCR10 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr10 35
  • 84.9 (n)
  • 88.12 (a)
chicken
(Gallus gallus)
Aves CCR10 35
  • 61.9 (n)
  • 53.02 (a)
CCR10 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCR10 36
  • 41 (a)
OneToOne
Species with no ortholog for CCR10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR10 Gene

ENSEMBL:
Gene Tree for CCR10 (if available)
TreeFam:
Gene Tree for CCR10 (if available)

Paralogs for CCR10 Gene

(23) SIMAP similar genes for CCR10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCR10: view

No data available for Paralogs for CCR10 Gene

Variants for CCR10 Gene

Sequence variations from dbSNP and Humsavar for CCR10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs61730696 -- 42,679,666(+) ACCCC(A/G)TAGCA reference, missense
rs61730697 -- 42,679,790(+) TTGCT(A/G)GCAGG reference, synonymous-codon
rs72826958 -- 42,679,363(+) CGCCA(C/T)AAATC downstream-variant-500B
rs113100096 -- 42,679,632(+) CGCGG(C/G)GGGGT reference, missense
rs113372582 -- 42,680,396(+) AGCTG(C/G)AGCAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CCR10 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv908256 CNV Loss 21882294
nsv833450 CNV Loss 17160897
esv1007587 CNV Deletion 20482838

Variation tolerance for CCR10 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR10 Gene

HapMap Linkage Disequilibrium report
CCR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR10 Gene

Disorders for CCR10 Gene

Relevant External Links for CCR10

Human Genome Epidemiology (HuGE) Navigator
CCR10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR10

No disorders were found for CCR10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCR10 Gene

Publications for CCR10 Gene

  1. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A. … O'Dowd B.F. (Genomics 1994) 2 3 4 67
  2. CCR4 and CCR10 are expressed on epidermal keratinocytes and are involved in cutaneous immune reaction. (PMID: 18782672) Fujimoto S. … Tamaki K. (Cytokine 2008) 3 23
  3. In vitro and in vivo studies on CCR10 regulation by Annexin A1. (PMID: 16460738) Rodrigues-Lisoni F.C. … Solito E. (FEBS Lett. 2006) 3 23
  4. Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides. (PMID: 16675558) Fujita Y. … Shimizu H. (Clin. Cancer Res. 2006) 3 23
  5. CCR10 is expressed in cutaneous T-cell lymphoma. (PMID: 15700309) Notohamiprodjo M. … von Luettichau I. (Int. J. Cancer 2005) 3 23

Products for CCR10 Gene

Sources for CCR10 Gene

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