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Aliases for CCR10 Gene

Aliases for CCR10 Gene

  • Chemokine (C-C Motif) Receptor 10 2 3
  • GPR2 3 4 6
  • G Protein-Coupled Receptor 2 2 3
  • G-Protein Coupled Receptor 2 3 4
  • C-C CKR-10 3 4
  • CC-CKR-10 3 4
  • CCR-10 3 4
  • C-C Chemokine Receptor Type 10 3
  • CC Chemokine Receptor 10 3

External Ids for CCR10 Gene

Previous HGNC Symbols for CCR10 Gene

  • GPR2

Previous GeneCards Identifiers for CCR10 Gene

  • GC17M038086
  • GC17M040830
  • GC17M036600

Summaries for CCR10 Gene

Entrez Gene Summary for CCR10 Gene

  • Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CCR10 Gene

CCR10 (Chemokine (C-C Motif) Receptor 10) is a Protein Coding gene. Diseases associated with CCR10 include pthirus pubis infestation. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR10 Gene

  • Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line

Gene Wiki entry for CCR10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR10 Gene

Genomics for CCR10 Gene

Regulatory Elements for CCR10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCR10 Gene

Start:
42,678,889 bp from pter
End:
42,683,917 bp from pter
Size:
5,029 bases
Orientation:
Minus strand

Genomic View for CCR10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR10 Gene

Proteins for CCR10 Gene

  • Protein details for CCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46092-CCR10_HUMAN
    Recommended name:
    C-C chemokine receptor type 10
    Protein Accession:
    P46092
    Secondary Accessions:
    • Q4V749
    • Q6T7X2
    • Q9NZG2

    Protein attributes for CCR10 Gene

    Size:
    362 amino acids
    Molecular mass:
    38416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR10 Gene

Proteomics data for CCR10 Gene at MOPED

Post-translational modifications for CCR10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCR10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCR10 Gene

Domains for CCR10 Gene

Gene Families for CCR10 Gene

HGNC:
  • CCR :GPCR / Class A : Chemokine receptors : C-C motif
IUPHAR :

Suggested Antigen Peptide Sequences for CCR10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46092

UniProtKB/Swiss-Prot:

CCR10_HUMAN :
  • P46092
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR10: view

Function for CCR10 Gene

Molecular function for CCR10 Gene

UniProtKB/Swiss-Prot Function: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line

Gene Ontology (GO) - Molecular Function for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 7851889
GO:0004950 chemokine receptor activity --
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR10: view
genes like me logo Genes that share phenotypes with CCR10: view

Animal Models for CCR10 Gene

MGI Knock Outs for CCR10:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CCR10 Gene

Localization for CCR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR10 Gene COMPARTMENTS Subcellular localization image for CCR10 gene
Compartment Confidence
plasma membrane 5
extracellular 2
chloroplast 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7851889
GO:0009986 cell surface IDA 18308860
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CCR10: view

Pathways for CCR10 Gene

genes like me logo Genes that share pathways with CCR10: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006955 immune response IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0070098 chemokine-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with CCR10: view

Compounds for CCR10 Gene

(1) HMDB Compounds for CCR10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) IUPHAR Ligand for CCR10 Gene

Ligand Type Action Affinity Pubmed IDs
CCL28 Agonist Full agonist
CCL27 Agonist Full agonist

(1) Novoseek inferred chemical compound relationships for CCR10 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 1
genes like me logo Genes that share compounds with CCR10: view

Transcripts for CCR10 Gene

mRNA/cDNA for CCR10 Gene

Unigene Clusters for CCR10 Gene

Chemokine (C-C motif) receptor 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR10 Gene

No ASD Table

Relevant External Links for CCR10 Gene

GeneLoc Exon Structure for
CCR10
ECgene alternative splicing isoforms for
CCR10

Expression for CCR10 Gene

mRNA expression in normal human tissues for CCR10 Gene

mRNA differential expression in normal tissues according to GTEx for CCR10 Gene

This gene is overexpressed in Pituitary (5.1).

SOURCE GeneReport for Unigene cluster for CCR10 Gene Hs.744542

mRNA Expression by UniProt/SwissProt for CCR10 Gene

P46092-CCR10_HUMAN
Tissue specificity: Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.
genes like me logo Genes that share expressions with CCR10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CCR10 Gene

Orthologs for CCR10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR10 35
  • 99.36 (n)
  • 100 (a)
CCR10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCR10 35
  • 88.27 (n)
  • 91.97 (a)
CCR10 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR10 35
  • 88.92 (n)
  • 92.24 (a)
CCR10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr10 35
  • 84.99 (n)
  • 88.12 (a)
Ccr10 16
Ccr10 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCR10 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr10 35
  • 84.9 (n)
  • 88.12 (a)
chicken
(Gallus gallus)
Aves CCR10 35
  • 61.9 (n)
  • 53.02 (a)
CCR10 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCR10 36
  • 41 (a)
OneToOne
Species with no ortholog for CCR10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR10 Gene

ENSEMBL:
Gene Tree for CCR10 (if available)
TreeFam:
Gene Tree for CCR10 (if available)

Paralogs for CCR10 Gene

Selected SIMAP similar genes for CCR10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCR10: view

Variants for CCR10 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCR10 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv908256 CNV Loss 21882294
nsv833450 CNV Loss 17160897
esv1007587 CNV Deletion 20482838

Relevant External Links for CCR10 Gene

HapMap Linkage Disequilibrium report
CCR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CCR10 Gene

Disorders for CCR10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CCR10 Gene including...

Search for CCR10 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CCR10 Gene

(10) Novoseek inferred disease relationships for CCR10 Gene

Disease -log(P) Hits PubMed IDs
lymphoma t-cell cutaneous 66.6 3
mycosis fungoides 65.5 2
sezary syndrome 63 3
dermatitis 42.7 3
skin diseases 34.6 1

Relevant External Links for CCR10

Human Genome Epidemiology (HuGE) Navigator
CCR10
genes like me logo Genes that share disorders with CCR10: view

No data available for UniProtKB/Swiss-Prot for CCR10 Gene

Publications for CCR10 Gene

  1. Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. (PMID: 10725696) Jarmin D.I. … Gerard C. (J. Immunol. 2000) 3 4 23
  2. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). (PMID: 10725697) Homey B. … Zlotnik A. (J. Immunol. 2000) 3 4 23
  3. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PMID: 10975800) Pan J. … Soler D. (J. Immunol. 2000) 3 4 23
  4. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A. … O'Dowd B.F. (Genomics 1994) 2 3 4
  5. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). (PMID: 10781587) Wang W. … Zlotnik A. (J. Biol. Chem. 2000) 3 4

Products for CCR10 Gene

Sources for CCR10 Gene

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