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Aliases for CCR10 Gene

Aliases for CCR10 Gene

  • C-C Motif Chemokine Receptor 10 2 3 5
  • Chemokine (C-C Motif) Receptor 10 2 3
  • G-Protein Coupled Receptor 2 3 4
  • C-C CKR-10 3 4
  • CC-CKR-10 3 4
  • CCR-10 3 4
  • GPR2 3 4
  • C-C Chemokine Receptor Type 10 3
  • G Protein-Coupled Receptor 2 2
  • CC Chemokine Receptor 10 3

External Ids for CCR10 Gene

Previous HGNC Symbols for CCR10 Gene

  • GPR2

Previous GeneCards Identifiers for CCR10 Gene

  • GC17M038086
  • GC17M040830
  • GC17M036600

Summaries for CCR10 Gene

Entrez Gene Summary for CCR10 Gene

  • Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CCR10 Gene

CCR10 (C-C Motif Chemokine Receptor 10) is a Protein Coding gene. Diseases associated with CCR10 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Akt Signaling and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. GO annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity.

UniProtKB/Swiss-Prot for CCR10 Gene

  • Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Gene Wiki entry for CCR10 Gene

Additional gene information for CCR10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR10 Gene

Genomics for CCR10 Gene

Regulatory Elements for CCR10 Gene

Enhancers for CCR10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H043322 1.7 Ensembl ENCODE dbSUPER 54.4 -639.2 -639246 1.6 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 NFYC ENSG00000267340 UBTF ASB16-AS1 ENSG00000267002 DHX8 HMGN1P29 TMUB2 NBR2 PLEKHH3 LINC00910
GH17H041687 1.7 Ensembl ENCODE dbSUPER 13.3 +993.5 993519 6.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 ENSG00000267758 ENSG00000259623 KLHL10 CNTNAP1 HSD17B1 NT5C3B KAT2A KLHL11 ACLY TMEM99
GH17H042515 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +162.0 162025 12.2 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 MLX TUBG2 ENSG00000267002 CAVIN1 NAGLU ENSG00000267340 RAB5C KAT2A ATP6V0A1 RNU7-97P
GH17H042672 1.4 ENCODE dbSUPER 14.5 +5.2 5220 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 CNTNAP1 TUBG2 ENSG00000267340 ENSG00000267002 HSD17B1 HSD17B1P1 HMGN2P15 ENSG00000259623 MLX KAT2A
GH17H043366 1.7 Ensembl ENCODE dbSUPER 10.8 -684.8 -684798 4 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 DHX8 NBR2 HMGN1P29 ASB16-AS1 LINC00910 TMUB2 UBTF ENSG00000267340 PSME3 NBR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCR10 on UCSC Golden Path with GeneCards custom track

Promoters for CCR10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094449 1117 801 HDGF ARID4B DMAP1 ZNF143 RUNX3 SP5 YY2 MXD4 MIER2 KAT8

Genomic Locations for CCR10 Gene

Genomic Locations for CCR10 Gene
5,029 bases
Minus strand

Genomic View for CCR10 Gene

Genes around CCR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR10 Gene

Proteins for CCR10 Gene

  • Protein details for CCR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-C chemokine receptor type 10
    Protein Accession:
    Secondary Accessions:
    • Q4V749
    • Q6T7X2
    • Q9NZG2

    Protein attributes for CCR10 Gene

    362 amino acids
    Molecular mass:
    38416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCR10 Gene

Post-translational modifications for CCR10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCR10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCR10 Gene

Domains & Families for CCR10 Gene

Gene Families for CCR10 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CCR10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR10: view

Function for CCR10 Gene

Molecular function for CCR10 Gene

UniProtKB/Swiss-Prot Function:
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Phenotypes From GWAS Catalog for CCR10 Gene

Gene Ontology (GO) - Molecular Function for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS 7851889
GO:0004950 chemokine receptor activity IEA --
GO:0005515 protein binding IPI 26941067
GO:0016493 C-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CCR10: view
genes like me logo Genes that share phenotypes with CCR10: view

Animal Models for CCR10 Gene

MGI Knock Outs for CCR10:

Clone Products

  • Addgene plasmids for CCR10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCR10 Gene

Localization for CCR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCR10 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7851889
GO:0009986 cell surface IDA 18308860
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCR10: view

Pathways & Interactions for CCR10 Gene

genes like me logo Genes that share pathways with CCR10: view

Gene Ontology (GO) - Biological Process for CCR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with CCR10: view

No data available for SIGNOR curated interactions for CCR10 Gene

Drugs & Compounds for CCR10 Gene

(3) Drugs for CCR10 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL27 Pharma Full agonist, Agonist 0
CCL28 Pharma Full agonist, Agonist 0
calcium Nutra 0
genes like me logo Genes that share compounds with CCR10: view

Transcripts for CCR10 Gene

mRNA/cDNA for CCR10 Gene

Unigene Clusters for CCR10 Gene

Chemokine (C-C motif) receptor 10:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCR10

Alternative Splicing Database (ASD) splice patterns (SP) for CCR10 Gene

No ASD Table

Relevant External Links for CCR10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCR10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCR10 Gene

mRNA differential expression in normal tissues according to GTEx for CCR10 Gene

This gene is overexpressed in Pituitary (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of CCR10 Gene:


SOURCE GeneReport for Unigene cluster for CCR10 Gene:


mRNA Expression by UniProt/SwissProt for CCR10 Gene:

Tissue specificity: Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.
genes like me logo Genes that share expression patterns with CCR10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCR10 Gene

Orthologs for CCR10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCR10 33 34
  • 99.36 (n)
(Canis familiaris)
Mammalia CCR10 33 34
  • 88.92 (n)
(Bos Taurus)
Mammalia CCR10 33 34
  • 88.27 (n)
(Mus musculus)
Mammalia Ccr10 33 16 34
  • 84.99 (n)
(Rattus norvegicus)
Mammalia Ccr10 33
  • 84.9 (n)
(Monodelphis domestica)
Mammalia CCR10 34
  • 82 (a)
(Gallus gallus)
Aves CCR10 33 34
  • 61.9 (n)
(Anolis carolinensis)
Reptilia CCR10 34
  • 41 (a)
Species where no ortholog for CCR10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR10 Gene

Gene Tree for CCR10 (if available)
Gene Tree for CCR10 (if available)

Paralogs for CCR10 Gene

(23) SIMAP similar genes for CCR10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCR10: view

No data available for Paralogs for CCR10 Gene

Variants for CCR10 Gene

Sequence variations from dbSNP and Humsavar for CCR10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001097202 -- 42,680,678(+) CCCCC(A/G)CCCAC intron-variant, upstream-variant-2KB
rs1001277959 -- 42,680,357(+) AAGGG(C/G)AGAGT reference, synonymous-codon, utr-variant-5-prime
rs1002087060 -- 42,679,337(+) GGGGT(G/T)TTAAC downstream-variant-500B, upstream-variant-2KB
rs1002695110 -- 42,681,018(+) TTATT(A/T)ATTAT intron-variant, upstream-variant-2KB
rs1003292726 -- 42,682,605(+) GAGGA(C/T)AGAGA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CCR10 Gene

Variant ID Type Subtype PubMed ID
nsv953899 CNV deletion 24416366
nsv833450 CNV loss 17160897
nsv1146669 OTHER inversion 26484159
nsv1118758 CNV deletion 24896259
esv33998 OTHER inversion 15654335
esv1007587 CNV deletion 20482838

Variation tolerance for CCR10 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR10 Gene

Disorders for CCR10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCR10 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
mycosis fungoides
  • mf
sezary's disease
  • sezary disease
- elite association - COSMIC cancer census association via MalaCards
Search CCR10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR10

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCR10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR10 Gene

Publications for CCR10 Gene

  1. Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. (PMID: 10725696) Jarmin DI … Gerard C (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 60
  2. Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). (PMID: 10725697) Homey B … Zlotnik A (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 60
  3. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PMID: 10975800) Pan J … Soler D (Journal of immunology (Baltimore, Md. : 1950) 2000) 3 4 22 60
  4. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A … O'Dowd BF (Genomics 1994) 2 3 4 60
  5. CCR4 and CCR10 are expressed on epidermal keratinocytes and are involved in cutaneous immune reaction. (PMID: 18782672) Fujimoto S … Tamaki K (Cytokine 2008) 3 22 60

Products for CCR10 Gene

  • Addgene plasmids for CCR10

Sources for CCR10 Gene