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CCR10 Gene

protein-coding   GIFtS: 57
GCID: GC17M040830

Chemokine (C-C Motif) Receptor 10

(Previous name: G protein-coupled receptor 2)
(Previous symbol: GPR2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Receptor 101 2     C-C CKR-102 3
GPR21 2 3 5     G-Protein Coupled Receptor 22 3
G Protein-Coupled Receptor 21 2     C-C Chemokine Receptor Type 102
CC-CKR-102 3     CC Chemokine Receptor 102
CCR-102 3     

External Ids:    HGNC: 44741   Entrez Gene: 28262   Ensembl: ENSG000001844517   OMIM: 6002405   UniProtKB: P460923   

Export aliases for CCR10 gene to outside databases

Previous GC identifers: GC17M038086 GC17M036600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCR10 Gene:
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that
regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G
protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function
of the immune system, and they have effects on cells of the central nervous system as well as on endothelial
cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based
on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single
amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM
604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 (PubMed
11821900)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CCR10 Gene:
CCR10 (chemokine (C-C motif) receptor 10) is a protein-coding gene. Diseases associated with CCR10 include testicular leukemia, and sezary's disease. GO annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCR10_HUMAN, P46092
Function: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the
intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line

Gene Wiki entry for CCR10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CCR10 gene promoter:
         AP-1   AML1a   ATF-2   c-Jun   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR10 promoter sequence
   Search Chromatin IP Primers for CCR10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1-q21.3   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.1-q21.3

CCR10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040830:  view genomic region     (about GC identifiers)

Start:
40,830,907 bp from pter      End:
40,835,935 bp from pter
Size:
5,029 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCR10_HUMAN, P46092 (See protein sequence)
Recommended Name: C-C chemokine receptor type 10  
Size: 362 amino acids; 38416 Da
Secondary accessions: Q4V749 Q6T7X2 Q9NZG2

Explore the universe of human proteins at neXtProt for CCR10: NX_P46092

Explore proteomics data for CCR10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCR10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057686.2  
    ENSEMBL proteins: 
     ENSP00000332504   ENSP00000468135   ENSP00000467331  
    Reactome Protein details: P46092

    CCR10 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    CCR10 Assay Products:

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    GenScript Custom Assay Services for CCR10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCR10
    Cloud-Clone Corp. CLIAs for CCR10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR10
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR005382 Chemokine_CCR10
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P46092

    ProtoNet protein and cluster: P46092

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB005382 C-C chemokine receptor type 10 signature


    UniProtKB/Swiss-Prot: CCR10_HUMAN, P46092
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CCR10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR10_HUMAN, P46092
    Function: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the
    intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS7851889
    GO:0004950chemokine receptor activity ----
    GO:0016493C-C chemokine receptor activity IEA--
         
    CCR10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCR10:
     Increased HPV18 LCR reporter a 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccr10):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     immune system  integument  mortality/aging  muscle  nervous system 
     normal  skeleton 

    CCR10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CCR10: Ccr10tm1Cge Ccr10/Cntnap1Ccr10/tm1Bhat

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR10

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate CCR10
    SwitchGear 3'UTR luciferase reporter plasmidCCR10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCR10
    Predesigned siRNA for gene silencing in human, mouse, rat CCR10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCR10

    Clone
    Products:
         
    OriGene clones in human, mouse for CCR10 (see all 6)
    OriGene ORF clones in mouse, rat for CCR10
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    GenScript: all cDNA clones in your preferred vector: CCR10 (NM_016602)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR10

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCR10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCR10_HUMAN, P46092: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    chloroplast1
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7851889
    GO:0016021integral component of membrane ----

    CCR10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCR10 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCR10
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR10 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 BioSystems Pathways for CCR10
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for CCR10
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for CCR10):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Intestinal immune network for IgA production


    CCR10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR10: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Th1/Th2 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCR10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCR10 (P460922, 3 ENSP000003325044) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62802 MINT-62628 MINT-62726 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62802 MINT-62628 MINT-62726 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486342, 3, ENSP000003651754MINT-62802 MINT-62628 MINT-62726 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486342, 3MINT-62802 MINT-62628 MINT-62726 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62802 MINT-62628 MINT-62726 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006935chemotaxis IEA--
    GO:0006955immune response IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS7851889
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0070098chemokine-mediated signaling pathway ----

    CCR10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCR10

    1 HMDB Compound for CCR10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 IUPHAR Ligands for CCR10 (CCR10)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCL28
    AgonistFull agonist--
    CCL27
    AgonistFull agonist--

    1 Novoseek inferred chemical compound relationship for CCR10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 1 10725697 (1)



    CCR10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCR10 gene: 
    NM_016602.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332438(uc002iax.4) ENST00000591765 ENST00000591568
    miRNA
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    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat CCR10
    Clone
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    GenScript: all cDNA clones in your preferred vector: CCR10 (NM_016602)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCR10
      QuantiTect SYBR Green Assays in human, mouse, rat CCR10
      QuantiFast Probe-based Assays in human, mouse, rat CCR10

    Selected AceView cDNA sequences (see all 26):

    AY429103 CR613205 BU633207 BM683661 CK299231 BM694157 BU633580 AF208237 
    BG682791 BE260527 BQ186076 BX283417 NM_016602 BM930170 CA423133 AF215981 
    BI600146 AL523112 BG683450 BU079135 CA777185 AW664477 BU078856 AL523111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCR10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGAAAA
    CCR10 Expression
    About this image

    CCR10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCR10 Protein Expression

    UniProtKB/Swiss-Prot: CCR10_HUMAN, P46092
    Tissue specificity: Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker
    expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon,
    heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal
    fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans
    cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR10: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Th1/Th2 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCR10
    OriGene qSTAR qPCR primer pairs in human, mouse for CCR10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCR10
    QuantiTect SYBR Green Assays in human, mouse, rat CCR10
    QuantiFast Probe-based Assays in human, mouse, rat CCR10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCR10 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr101 , 5 chemokine (C-C motif) receptor 101, 5 84.99(n)1
    88.12(a)1
      11 (64.34 cM)5
    127771  NM_007721.41  NP_031747.21 
     1011729975 
    chicken
    (Gallus gallus)
    Aves CCR101 chemokine (C-C motif) receptor 10 61.9(n)
    53.02(a)
      100858200  XM_004948620.1  XP_004948677.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCR106
    chemokine (C-C motif) receptor 10
    41(a)
    1 ↔ 1
    6(61880021-61884173)


    ENSEMBL Gene Tree for CCR10 (if available)
    TreeFam Gene Tree for CCR10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CCR10 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CCR82  CXCR22  CCR12  CCR42  CXCR12  
    CCR22  CXCR52  CCR32  CXCR42  
    Selected SIMAP similar genes for CCR10 using alignment to 3 protein entries:     CCR10_HUMAN (see all proteins) (see all similar genes):
    CCR6    CCR5    CXCR6    CCR7    CCR3    CCR4
    CXCR1    CCR2    CCR9    CXCR2    CXCR3    IL8RB
    XCR1    ACKR4    ACKR2    CCBP2    CCR1    CCR8

    CCR10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCR10 (see all 29)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728269581,2
    --40831381(+) CGCCAC/TAAATC 1 -- ds50010--------
    rs2015524961,2
    C--40831534(+) TCCCAC/GGACCC 1 -- ut311Minor allele frequency- G:0.00EU 1323
    rs1929862841,2
    C--40831554(+) CCCCTC/TCTCTA 1 -- ut310--------
    rs1405546251,2
    C,F--40831590(+) AGAGAC/GTGTGG 2 T S mis11Minor allele frequency- G:0.00NA 4352
    rs1998657871,2
    --40831663(+) AGGCCC/TTGAGG 2 R G mis10--------
    rs617306961,2
    C,F--40831684(+) ACCCCG/ATAGCA 2 /R /W mis13Minor allele frequency- A:0.09NS WA 190
    rs617306971,2
    C--40831808(+) TTGCTG/AGCAGG 2 /A syn11Minor allele frequency- A:0.01NS 72
    rs348664911,2
    C,F--40832195(+) CGGCCG/CGGAGT 2 /P syn13Minor allele frequency- C:0.01NA WA 3164
    rs2007913271,2
    C--40832216(+) GGCCCA/GGCTGG 2 A syn10--------
    rs2004731791,2
    --40832395(+) CAAGAA/GGTCGG 2 L F mis10--------

    HapMap Linkage Disequilibrium report for CCR10 (40830907 - 40835935 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCR10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1007587CNV Deletion20482838
    nsv833450CNV Loss17160897
    nsv908256CNV Loss21882294
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600240    OMIM disorders: --

    Selected diseases for CCR10 (see all 21):    
    About MalaCards
    testicular leukemia    sezary's disease    pthirus pubis infestation    cutaneous malignant melanoma
    contact dermatitis    allergic contact dermatitis    adult t-cell leukemia    mycosis fungoides
    cutaneous t cell lymphoma    skin disease    atopic dermatitis    dermatitis
    psoriasis    t-cell leukemia    endotheliitis    melanoma
    hepatitis b    hiv-1    hepatitis    leukemia

    2 diseases from the University of Copenhagen DISEASES database for CCR10:
    Pthirus pubis infestation     Allergic contact dermatitis

    CCR10 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for CCR10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell cutaneous 66.6 3 19242508 (1), 15727636 (1), 15700309 (1)
    mycosis fungoides 65.5 2 19242508 (1), 15700309 (1)
    sezary syndrome 63 3 15727636 (2), 15700309 (1)
    dermatitis 42.7 3 16735375 (1), 18782672 (1), 11821900 (1)
    skin diseases 34.6 1 10725697 (1)
    skin lesion 24.7 1 12406880 (1)
    psoriasis 24 1 11821900 (1)
    melanoma 4.65 6 14581607 (4), 16644201 (2)
    inflammation 0 1 15307136 (1)
    tumors 0 3 14581607 (2), 16675558 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCR10 (5 documents)

    Export disorders for CCR10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCR10 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with CCR10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human genes encoding novel G protein-coupled receptors. (PubMed id 7851889)1, 2, 3 Marchese A.... O'Dowd B.F. (Genomics 1994)
    2. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). (PubMed id 10725697)1, 2, 9 Homey B.... Zlotnik A. (J. Immunol. 2000)
    3. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. (PubMed id 10975800)1, 2, 9 Pan J.... Soler D. (J. Immunol. 2000)
    4. Identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. (PubMed id 10725696)1, 2, 9 Jarmin D.I.... Gerard C. (J. Immunol. 2000)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). (PubMed id 10781587)1, 2 Wang W.... Zlotnik A. (J. Biol. Chem. 2000)
    7. CCR4 and CCR10 are expressed on epidermal keratinocytes and are involved in cutaneous immune reaction. (PubMed id 18782672)1, 9 Fujimoto S....Tamaki K. (Cytokine 2008)
    8. CCR10 is expressed in cutaneous T-cell lymphoma. (PubMed id 15700309)1, 9 Notohamiprodjo M....von Luettichau I. (Int. J. Cancer 2005)
    9. In vitro and in vivo studies on CCR10 regulation by Annexin A1. (PubMed id 16460738)1, 9 Rodrigues-Lisoni F.C....Solito E. (FEBS Lett. 2006)
    10. Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides. (PubMed id 16675558)1, 9 Fujita Y....Shimizu H. (Clin. Cancer Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2826 HGNC: 4474 AceView: GPR2 Ensembl:ENSG00000184451 euGenes: HUgn2826
    ECgene: CCR10 Kegg: 2826 H-InvDB: CCR10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCR10 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCR10 gene:
    Search GeneIP for patents involving CCR10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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