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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCR1 Gene

protein-coding GIFtS: 65
GCID: GC03M046218

chemokine (C-C motif) receptor 1

(Previous symbols: SCYAR1, CMKBR1)

Explore 71 diseases affiliated with
CCR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Receptor 1¹ ²		MIP-1alpha-R² ³
CMKBR1¹ ² ³ ⁵		RANTES-R² ³
SCYAR1¹ ² ³		C-C CKR-1² ³
HM145² ³ ⁵		LD78 Receptor² ³
CD191¹ ²		CKR1² ⁵
CKR-1¹ ²		C-C Chemokine Receptor Type 1²
MIP1aR¹ ²		RANTES Receptor²
Macrophage Inflammatory Protein 1-Alpha Receptor² ³		CMKR1³
CC-CKR-1² ³		CD191 Antigen³
CCR-1² ³

External Ids:	HGNC: 1602¹	Entrez Gene: 1230²	Ensembl: ENSG00000163823⁷	OMIM: 601159⁵	UniProtKB: P32246³

Export aliases for CCR1 gene to outside databases

Previous GC identifers: GC03M045484 GC03M046062 GC03M046204

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCR1:

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane

protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1

alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte

chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors

mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation.

Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response,

and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3,

CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246

Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less

efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions

level. Responsible for affecting stem cell proliferation

summary for CCR1:

Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed

migration of immune cells. Over fifty human chemokines have been identified that can be categorised into

four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine

residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface

of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are

classified according to the class of chemokines that they bind. The major function of chemokines is to

regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include

angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of

chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by

cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCR1 gene promoter:
STAT1 AP-1 ATF-2 STAT1beta c-Ets-1 C/EBPalpha STAT1alpha c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCR1 promoter sequence

Search SABiosciences Chromatin IP Primers for CCR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21

CCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M046218: view genomic region (about GC identifiers)

Start:	46,243,200 bp from pter	End:	46,249,887 bp from pter
Size:	6,688 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246 (See protein sequence)

Recommended Name: C-C chemokine receptor type 1

Size: 355 amino acids; 41173 Da

Subunit: Interacts with CREB3

Subcellular location: Cell membrane; Multi-pass membrane protein

1 PDB 3D structure from and Proteopedia for CCR1:

1Y5D (3D)

Secondary accessions: Q86VA9

Explore the universe of human proteins at neXtProt for CCR1: NX_P32246

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P32246

CCR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001286.1

ENSEMBL proteins:

ENSP00000296140

Reactome Protein details: P32246
Human Recombinant Protein Products:

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	Uscn Proteins for CCR1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	7505609
GO:0009897	external side of plasma membrane	IDA	10706735

CCR1 for ontologies About GeneDecksing

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Assay Products for CCR1:

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	GenScript Custom Assay Services for CCR1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR002236 Chemokine_CCR1

IPR000355 Chemokine_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P32246

ProtoNet protein and cluster: P32246

2 Blocks protein families:

IPB000355 Chemokine receptor signature

IPB002236 C-C chemokine receptor type 1 signature

UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246

Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less

efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions

level. Responsible for affecting stem cell proliferation

Induction: Up-regulated by CREB3

Genatlas biochemistry entry for CCR1:

chemokine CC, beta,receptor 1,with high affinity binding for monocyte chemoattractant protein 3,G protein coupled

receptor superfamily

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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCR1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphatidylinositol phospholipase C activity	IDA	10734056
GO:0004950	chemokine receptor activity	IDA	10660125
GO:0005515	protein binding	IPI	15474493
GO:0016493	C-C chemokine receptor activity	IDA	10734056
GO:0019957	C-C chemokine binding	IPI	8699119

CCR1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CCR1: Ccr1^tm1Gao Ccr1^tm1Cge
     10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccr1):

cardiovascular system	cellular	digestive/alimentary	hematopoietic system	homeostasis/metabolism
immune system	liver/biliary system	mortality/aging	renal/urinary system	respiratory system

CCR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Chemokine Signaling

Chemokine Signaling

1.00

Chemokine signaling pathway

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CCR1

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR1 (see all 8)

	Chemokine Signaling
	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Tec Kinases Signaling

2 BioSystems Pathways for CCR1

	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

5/8 Reactome Pathways for CCR1 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Chemokine receptors bind chemokines
	Signal Transduction
	Signaling by GPCR

2 Kegg Pathways (Kegg details for CCR1):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

CCR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/193 Interacting proteins for CCR1 (P32246^{1, 3} ENSP00000296140⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 193)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLP2	Q04941¹^,³, ENSP00000365505⁴	EBI-608322,EBI-608347 I2D: score=4 STRING: ENSP00000365505
CREB3	O43889-2¹, ENSP00000342136⁴	EBI-608322,EBI-625022 I2D: score=2 STRING: ENSP00000342136
CCL3L3	P16619³, ENSP00000367605⁴	I2D: score=3 STRING: ENSP00000367605
CCL7	P80098³, ENSP00000200307⁴	I2D: score=4 STRING: ENSP00000200307
CCL2	P13500³, ENSP00000225831⁴	I2D: score=3 STRING: ENSP00000225831

About this table

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002407	dendritic cell chemotaxis	TAS	16621978
GO:0006816	calcium ion transport	IDA	10734056
GO:0006874	cellular calcium ion homeostasis	IDA	10734056
GO:0006887	exocytosis	IDA	10734056
GO:0006935	chemotaxis	NAS	15474493

CCR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CCR1 available from Tocris Bioscience About this table

Compound	Action	CAS #
J 113863	Potent CCR1 chemokine receptor antagonist	[353791-85-2]

1 HMDB Compound for CCR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

10/28 Novoseek chemical compound relationships for CCR1 gene (see all 28) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	92.6	148	11903822 (4), 8521958 (3), 10713092 (3), 14964455 (3) (see all 90)
ccl3	90.6	55	16197470 (5), 12651617 (3), 16284949 (3), 17298994 (2) (see all 33)
bx471	85.3	8	17234893 (3), 15716328 (2), 17312463 (1), 12958070 (1) (see all 5)
ccl4	63.9	13	12651617 (1), 15848520 (1), 19127964 (1), 19383907 (1) (see all 10)
mdms	57.8	1	16741883 (1)
calcium	50.1	26	16365449 (2), 8955214 (1), 9632350 (1), 12529679 (1) (see all 23)
shikonin	45	6	11360924 (4), 12936978 (1)
piperidine	34.5	1	12574358 (1)
glycosaminoglycan	12.9	2	10766793 (1)
cycloheximide	7.37	6	17389578 (1), 15067079 (1)

Search CenterWatch for drugs/clinical trials and news about CCR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCR1 gene:

NM_001295.2

Unigene Cluster for CCR1:

Chemokine (C-C motif) receptor 1

Hs.301921 [show with all ESTs]

Unigene Representative Sequence: NM_001295

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000296140(uc003cph.1)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR1

Additional cDNA sequence:

BC051306.1 BC064991.1 BT019908.1 BT019909.1 D10925.1 L09230.1 L10918.1

3 DOTS entries:

DT.443651 DT.120855622 DT.75140407

24/90 AceView cDNA sequences (see all 90):

BE326886 BC051306 AI690129 BF115835 BM917063 AI373605 BI963080 BC064991

BI962916 AI423006 BE670754 CR609171 AI358976 AI279301 BM917763 CK903574

AI335823 AI580333 AI421071 BE220875 AI271823 BF438487 AL552677 CA309864

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTGTTCT

About this image

CCR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Bone marrow-derived mesenchymal stem cells (Stempeucel) (Adult Stem / Progenitor Cell)

Bone

Late limb mesenchymal cells (LLM cells) (Primary Cell)

Bone, Cartilage, Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCR1

SOURCE GeneReport for Unigene cluster: Hs.301921

UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246

Tissue specificity: Widely expressed in different hematopoietic cells

SABiosciences Expression via Pathway-Focused PCR Arrays including CCR1 (see all 13):

Multiple Sclerosis in human mouse rat

Lymphoma in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

T-cell & B-cell Activation in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCR1 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NPK9_CHICK⁶ F1NPK8_CHICK⁶	chemokine (C-C motif) receptor 2	59(a) 57(a)	many ↔ many many ↔ many	2(42682320-42683396) 2(42699264-42700328)
lizard (Anolis carolinensis)	Reptilia	-- --	--	56(a) 56(a)	many ↔ many many ↔ many	GL343324.1(448159-449136) GL343324.1(443935-445008)
zebrafish (Danio rerio)	Actinopterygii	CU467889.1⁶ ccr8.1⁶ (see all 3)	chemokine (C-C motif) receptor 8.1 (see all 3)	34(a) 33(a) (see all 3)	many ↔ many many ↔ many (see all 3)	16(11002252-11005272) 16(10749803-10752840)

ENSEMBL Gene Tree for CCR1 (if available)
TreeFam Gene Tree for CCR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCR1 gene

CCR6² CCR5² CXCR6² CXCR3² XCR1² CCR9² CCBP2² CCRL2²

CCR7² CX3CR1² CCR8² CXCR2² CCRL1² CCR4² CXCR1² CCR2²

CXCR5² CCR10² CCR3² CXCR4²

18/58 SIMAP similar genes for CCR1 using alignment to 2 protein entries: CCR1_HUMAN (see all proteins) (see all similar genes):

CCR-5 CCR3 CCR5 CCR2 CCR4 CCR8

CX3CR1 CCR7 AGTR1 CCR6 CCRL2 XCR1

BDKRB2 BLR1 CCBP2 CXCR1 CXCR2 CXCR3

CCR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3136672^1,2	C,F,O,H,	--	46242785(-)	`CACACA/GCCCCC`	1	--	ds500¹		16		NA NS EA WA CSA	952
rs184412822^1,2		--	46242820(+)	`GTCCAA/CAAAAG`	1	--	ds500¹		0	--	--	--	--
rs17078704^1,2	C,F,H,	--	46242874(+)	`CACCCG/ATCAGC`	1	--	ds500¹		8		NA NS EA	674
rs144509209^1,2		--	46243109(+)	`CTGGGC/TTGAAC`	1	--	ds500¹		0	--	--	--	--
rs3136671^1,2	C,F,O,H,	--	46243175(-)	`AAGTCG/ATTGGC`	1	--	ds500¹		26		NA EA MN NS	2764
rs187551313^1,2	C,	--	46243290(+)	`GAAGTA/CCATCA`	1	--	ut3¹		0	--	--	--	--
rs3136670^1,2	C,F,H,	--	46243361(-)	`CCACTG/ATGTGC`	1	--	ut3¹ ese³		12		NA NS EA CSA WA	1254
rs192816182^1,2		--	46243533(+)	`GGGTCC/GTTGGT`	1	--	ut3¹		0	--	--	--	--
rs114692441^1,2	C,F,	--	46243665(+)	`CCCCTA/CTCAGC`	1	--	ut3¹		1		WA	118
rs41391847^1,2	C,F,	--	46243690(-)	`GCTGTG/ATAAGC`	1	--	ut3¹		2		NA WA	166

HapMap Linkage Disequilibrium report for CCR1 (46243200 - 46249887 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCR1: --
Human Gene Mutation Database (HGMD): CCR1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CCR1 for disorders           About GeneDecksing

OMIM gene information: 601159    OMIM disorders: --

20/71 diseases for CCR1 (see all 71):    About MalaCards

immune-complex glomerulonephritis hematopoiesis mesangial proliferative glomerulonephritis lichen planus

proliferative glomerulonephritis oral lichen planus severe combined immunodeficiency avian influenza

burkitt's lymphoma chromoblastomycosis combined immunodeficiency chronic granulomatous disease

oral squamous cell carcinoma squamous cell carcinoma reactive arthritis myeloid leukemia

glomerulonephritis cytomegalovirus infection acute lymphoblastic leukemia rheumatoid arthritis

2 diseases from the University of Copenhagen DISEASES database for CCR1:

Multiple sclerosis Arthritis

10/36 Novoseek disease relationships for CCR1 gene (see all 36) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	53.3	23	17484785 (2), 14734772 (2), 17513790 (2), 17229070 (1) (see all 16)
immunodeficiency	46.7	2	9765485 (1), 9460925 (1)
multiple sclerosis	42.1	7	19689388 (1), 16022568 (1), 16857269 (1), 12381680 (1)
rheumatoid arthritis	37.7	6	19689388 (1), 19017998 (1), 16022568 (1), 12909630 (1)
endometriosis	16.9	10	15950672 (2), 17261287 (2), 19050323 (2), 16679772 (1) (see all 5)
demyelination	15.7	1	17484785 (1)
osteosarcoma	14.8	6	12759139 (1), 16226254 (1), 11943214 (1), 19951712 (1)
necrosis	13.4	5	15860797 (1), 19001077 (1), 18393858 (1), 15223905 (1) (see all 5)
tumors	10.4	15	20154287 (3), 14678997 (2), 11156420 (1), 15662971 (1) (see all 11)
arthritis	9.95	6	17016504 (2), 17929797 (1), 16107514 (1)

Genetic Association Database (GAD): CCR1
Human Genome Epidemiology (HuGE) Navigator: CCR1 (18 documents)

Export disorders for CCR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCR1 gene, integrated from 9 sources (see all 479):
(articles sorted by number of sources associating them with CCR1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. (PubMed id 7679328)^{1, 2, 3} Neote K.... Schall T.J. (1993)
Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. (PubMed id 15001559)^{1, 2, 9} Ko J.... Na D.S. (2004)
Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PubMed id 7505609)^{1, 2, 9} Nomura H.... Matsushima K. (1993)
Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. (PubMed id 18587271)^{1, 2, 9} Sung H.J....Ko J. (2008)
Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. (PubMed id 16323127)^{1, 4} Shrestha S....Smith M.W. (2006)
CCR5Delta32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis. (PubMed id 16182378)^{1, 4} Kantarci O.H....Lucchinetti C.F. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. (PubMed id 7683036)^{1, 2} Gao J.-L....Murphy P.M. (1993)
Trophoblasts acquire a chemokine receptor, CCR1, as they differentiate towards invasive phenotype. (PubMed id 14530297)^{1, 9} Sato Y....Fujii S. (2003)
CCR1 knockdown suppresses human non-small cell lung cancer cell invasion. (PubMed id 18972130)^{1, 9} Wang C.L....Cao W.Z. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1230	HGNC: 1602	AceView: CCR1	Ensembl:ENSG00000163823	euGenes: HUgn1230
ECgene: CCR1	Kegg: 1230	H-InvDB: CCR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCR1	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/CC_chemokine_receptors

Intellectual Property for CCR1 gene
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chemokine (C-C motif) receptor 1

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CCR1 (Gene Symbol)
Chemokine (C-C Motif) Receptor 1
CMKBR1
SCYAR1
HM145
CD191
CKR-1
MIP1aR
Macrophage Inflammatory Protein 1-Alpha Receptor
CC-CKR-1
CCR-1
MIP-1alpha-R
RANTES-R
C-C CKR-1
LD78 Receptor
CKR1
C-C Chemokine Receptor Type 1
RANTES Receptor
CMKR1
CD191 Antigen

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CCR1 Gene

chemokine (C-C motif) receptor 1

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