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Aliases for CCR1 Gene

Aliases for CCR1 Gene

  • C-C Motif Chemokine Receptor 1 2 3
  • Chemokine (C-C Motif) Receptor 1 2 3 5
  • Macrophage Inflammatory Protein 1-Alpha Receptor 3 4
  • LD78 Receptor 3 4
  • MIP-1alpha-R 3 4
  • C-C CKR-1 3 4
  • CC-CKR-1 3 4
  • RANTES-R 3 4
  • CMKBR1 3 4
  • SCYAR1 3 4
  • CCR-1 3 4
  • HM145 3 4
  • RANTES Receptor 3
  • CD191 Antigen 4
  • MIP1aR 3
  • CD191 3
  • CKR-1 3
  • CMKR1 4
  • CKR1 3

External Ids for CCR1 Gene

Previous HGNC Symbols for CCR1 Gene

  • SCYAR1
  • CMKBR1

Previous GeneCards Identifiers for CCR1 Gene

  • GC03M045484
  • GC03M046062
  • GC03M046204

Summaries for CCR1 Gene

Entrez Gene Summary for CCR1 Gene

  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR1 Gene

CCR1 (C-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CCR1 include Chromoblastomycosis and Immune-Complex Glomerulonephritis. Among its related pathways are Peptide ligand-binding receptors and ERK Signaling. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CCR1 Gene

  • Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

Tocris Summary for CCR1 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Gene Wiki entry for CCR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR1 Gene

Genomics for CCR1 Gene

Regulatory Elements for CCR1 Gene

Enhancers for CCR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCR1 on UCSC Golden Path with GeneCards custom track

Promoters for CCR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCR1 Gene

Chromosome:
3
Start:
46,201,709 bp from pter
End:
46,208,396 bp from pter
Size:
6,688 bases
Orientation:
Minus strand

Genomic View for CCR1 Gene

Genes around CCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR1 Gene

Proteins for CCR1 Gene

  • Protein details for CCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32246-CCR1_HUMAN
    Recommended name:
    C-C chemokine receptor type 1
    Protein Accession:
    P32246
    Secondary Accessions:
    • Q86VA9

    Protein attributes for CCR1 Gene

    Size:
    355 amino acids
    Molecular mass:
    41173 Da
    Quaternary structure:
    • Interacts with CREB3.

    Three dimensional structures from OCA and Proteopedia for CCR1 Gene

neXtProt entry for CCR1 Gene

Proteomics data for CCR1 Gene at MOPED

Post-translational modifications for CCR1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCR1 Gene

Domains & Families for CCR1 Gene

Gene Families for CCR1 Gene

Suggested Antigen Peptide Sequences for CCR1 Gene

Graphical View of Domain Structure for InterPro Entry

P32246

UniProtKB/Swiss-Prot:

CCR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR1: view

Function for CCR1 Gene

Molecular function for CCR1 Gene

GENATLAS Biochemistry:
chemokine CC, beta,receptor 1,with high affinity binding for monocyte chemoattractant protein 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by CREB3.

Gene Ontology (GO) - Molecular Function for CCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8699119
GO:0019957 C-C chemokine binding IPI 7545673
GO:0071791 chemokine (C-C motif) ligand 5 binding IPI 7545673
genes like me logo Genes that share ontologies with CCR1: view
genes like me logo Genes that share phenotypes with CCR1: view

Animal Models for CCR1 Gene

MGI Knock Outs for CCR1:

Animal Model Products

miRNA for CCR1 Gene

miRTarBase miRNAs that target CCR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCR1 Gene

Localization for CCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR1 Gene COMPARTMENTS Subcellular localization image for CCR1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CCR1: view

Pathways & Interactions for CCR1 Gene

genes like me logo Genes that share pathways with CCR1: view

Gene Ontology (GO) - Biological Process for CCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006816 calcium ion transport IDA 10734056
GO:0006935 chemotaxis NAS 15474493
GO:0006955 immune response IDA 10734056
GO:0007155 cell adhesion TAS 10910894
genes like me logo Genes that share ontologies with CCR1: view

No data available for SIGNOR curated interactions for CCR1 Gene

Drugs & Compounds for CCR1 Gene

(35) Drugs for CCR1 Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL3 Pharma Full agonist, Agonist 0
CCL4 Pharma Antagonist 0
[<sup>125</sup>I]CCL3 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]CCL5 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]CCL7 (human) Pharma Full agonist, Agonist 0

(23) Additional Compounds for CCR1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CCL2
Full agonist, Agonist
2b-1
Antagonist
vMIP-II
Antagonist
DAPTA
106362-34-9
J 113863
353791-85-2

(5) Tocris Compounds for CCR1 Gene

Compound Action Cas Number
DAPTA Chemokine receptor 5 (CCR5) antagonist 106362-34-9
J 113863 Potent CCR1 chemokine receptor antagonist 353791-85-2
RS 102895 hydrochloride CCR2b chemokine receptor antagonist 1173022-16-6
RS 504393 Highly selective CCR2 chemokine receptor antagonist 300816-15-3
ZK 756326 Selective, non-peptide CCR8 agonist 874911-96-3
genes like me logo Genes that share compounds with CCR1: view

Transcripts for CCR1 Gene

mRNA/cDNA for CCR1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(90) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCR1 Gene

Chemokine (C-C motif) receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCR1 Gene

No ASD Table

Relevant External Links for CCR1 Gene

GeneLoc Exon Structure for
CCR1
ECgene alternative splicing isoforms for
CCR1

Expression for CCR1 Gene

mRNA expression in normal human tissues for CCR1 Gene

mRNA differential expression in normal tissues according to GTEx for CCR1 Gene

This gene is overexpressed in Whole Blood (x23.4) and Spleen (x4.8).

Protein differential expression in normal tissues from HIPED for CCR1 Gene

This gene is overexpressed in Monocytes (67.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCR1 Gene



SOURCE GeneReport for Unigene cluster for CCR1 Gene Hs.301921

mRNA Expression by UniProt/SwissProt for CCR1 Gene

P32246-CCR1_HUMAN
Tissue specificity: Widely expressed in different hematopoietic cells.
genes like me logo Genes that share expression patterns with CCR1: view

Protein tissue co-expression partners for CCR1 Gene

- Elite partner

Primer Products

Orthologs for CCR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCR1 35
  • 86.01 (n)
  • 84.51 (a)
-- 36
  • 62 (a)
OneToMany
CCR1 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCR1 35
  • 81.44 (n)
  • 78.69 (a)
mouse
(Mus musculus)
Mammalia Ccr1 35
  • 77.75 (n)
  • 80 (a)
Ccr1 16
Ccr1 36
  • 80 (a)
OneToMany
Ccr1l1 36
  • 62 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CCR1 35
  • 99.72 (n)
  • 99.72 (a)
CCR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr1 35
  • 78.5 (n)
  • 80 (a)
oppossum
(Monodelphis domestica)
Mammalia CCR1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCR1 36
  • 57 (a)
OneToOne
Species with no ortholog for CCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR1 Gene

ENSEMBL:
Gene Tree for CCR1 (if available)
TreeFam:
Gene Tree for CCR1 (if available)

Paralogs for CCR1 Gene

genes like me logo Genes that share paralogs with CCR1: view

Variants for CCR1 Gene

Sequence variations from dbSNP and Humsavar for CCR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17078704 -- 46,201,383(+) CACCC(A/G)TCAGC downstream-variant-500B
rs3053328 -- 46,208,458(+) TTCTT(-/C)TTTTT upstream-variant-2KB
rs3136663 -- 46,204,736(-) AATAA(A/G)AACAA intron-variant
rs3136664 -- 46,203,933(-) CTGCT(A/G)ACGAT reference, synonymous-codon
rs3136665 -- 46,203,079(-) GGCTT(C/T)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCR1 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294

Variation tolerance for CCR1 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR1 Gene

Human Gene Mutation Database (HGMD)
CCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR1 Gene

Disorders for CCR1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for CCR1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chromoblastomycosis
  • chromomycosis
immune-complex glomerulonephritis
  • immune complex glomerulonephritis
nut allergy
  • allergy to nuts
behcet's disease
  • adamantiades-behcet disease
mesangial proliferative glomerulonephritis
  • glomerulonephritis - mesangial proliferative
- elite association - COSMIC cancer census association via MalaCards
Search CCR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCR1

Genetic Association Database (GAD)
CCR1
Human Genome Epidemiology (HuGE) Navigator
CCR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR1
genes like me logo Genes that share disorders with CCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCR1 Gene

Publications for CCR1 Gene

  1. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. (PMID: 7679328) Neote K. … Schall T.J. (Cell 1993) 2 3 4 67
  2. C-C chemokine receptor 1 expression in human hematolymphoid neoplasia. (PMID: 20154287) Anderson M.W. … Natkunam Y. (Am. J. Clin. Pathol. 2010) 3 23
  3. Chemokine receptor expression in tumour islets and stroma in non-small cell lung cancer. (PMID: 20429924) Ohri C.M. … Bradding P. (BMC Cancer 2010) 3 23
  4. CCR1 knockdown suppresses human non-small cell lung cancer cell invasion. (PMID: 18972130) Wang C.L. … Cao W.Z. (J. Cancer Res. Clin. Oncol. 2009) 3 23
  5. CCR1 and CCR5 promote hepatic fibrosis in mice. (PMID: 19603542) Seki E. … Schwabe R.F. (J. Clin. Invest. 2009) 3 23

Products for CCR1 Gene

Sources for CCR1 Gene

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