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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCR1 Gene

protein-coding   GIFtS: 67
GCID: GC03M046218

Chemokine (C-C Motif) Receptor 1


(Previous symbols: SCYAR1, CMKBR1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Receptor 11 2     LD78 Receptor2 3
CMKBR11 2 3 5     CKR12 5
SCYAR11 2 3     CD1912
HM1452 3 5     CKR-12
Macrophage Inflammatory Protein 1-Alpha Receptor2 3     MIP1aR2
CC-CKR-12 3     C-C Chemokine Receptor Type 12
CCR-12 3     RANTES Receptor2
MIP-1alpha-R2 3     CMKR13
RANTES-R2 3     CD191 Antigen3
C-C CKR-12 3     

External Ids:    HGNC: 16021   Entrez Gene: 12302   Ensembl: ENSG000001638237   OMIM: 6011595   UniProtKB: P322463   

Export aliases for CCR1 gene to outside databases

Previous GC identifers: GC03M045484 GC03M046062 GC03M046204


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCR1 Gene:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane
protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory
protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte
chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their
receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of
inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from
inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes,
including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CCR1 Gene: 
CCR1 (chemokine (C-C motif) receptor 1) is a protein-coding gene. Diseases associated with CCR1 include immune-complex glomerulonephritis, and chromoblastomycosis, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Peptide GPCRs. GO annotations related to this gene include C-C chemokine receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CCR6.

UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246
Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less
efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium
ions level. Responsible for affecting stem cell proliferation

summary for CCR1 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCR1 gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   c-Ets-1   C/EBPalpha   STAT1alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M046218:  view genomic region     (about GC identifiers)

Start:
46,243,200 bp from pter      End:
46,249,887 bp from pter
Size:
6,688 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246 (See protein sequence)
Recommended Name: C-C chemokine receptor type 1  
Size: 355 amino acids; 41173 Da
Subunit: Interacts with CREB3
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for CCR1:
1Y5D (3D)    
Secondary accessions: Q86VA9

Explore the universe of human proteins at neXtProt for CCR1: NX_P32246

Explore proteomics data for CCR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32246

  • CCR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCR1 Protein Expression
    REFSEQ proteins: NP_001286.1  
    ENSEMBL proteins: 
     ENSP00000296140  
    Reactome Protein details: P32246
    Human Recombinant Protein Products for CCR1: 
    EMD Millipore Purified and/or Recombinant CCR1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCR1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCR1
    GenScript Custom Purified and Recombinant Proteins Services for CCR1
    Novus Biologicals CCR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCR1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7505609
    GO:0009897external side of plasma membrane IDA10706735
    GO:0016021integral to membrane ----

    CCR1 for ontologies           About GeneDecksing



    CCR1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CCR1 

    Assay Products for CCR1: 
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCR1 
    Cloud-Clone Corp. CLIAs for CCR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR1 
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002236 Chemokine_CCR1
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32246

    ProtoNet protein and cluster: P32246

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB002236 C-C chemokine receptor type 1 signature


    UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CCR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR1_HUMAN, P32246
    Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less
    efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium
    ions level. Responsible for affecting stem cell proliferation
    Induction: Up-regulated by CREB3

         Genatlas biochemistry entry for CCR1:
    chemokine CC, beta,receptor 1,with high affinity binding for monocyte chemoattractant protein 3,G protein coupled
    receptor superfamily

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IDA10734056
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity IDA10660125
    GO:0005515protein binding IPI15001559
    GO:0016493C-C chemokine receptor activity IDA10734056
         
    CCR1 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccr1):
     cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  renal/urinary system  respiratory system 

    CCR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CCR1: Ccr1tm1Gao Ccr1tm1Cge

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCR1:
    hsa-mir-21 (MIRT005956)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCR1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR1:
    hsa-miR-221* hsa-miR-511 hsa-miR-129-3p hsa-miR-129* hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidCCR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCR1
    Sirion Biotech Customized adenovirus for overexpression of CCR1

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of CCR1
    OriGene clones in human, mouse for CCR1 (see all 7)
    OriGene ORF clones in mouse, rat for CCR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCR1 (NM_001295)
    Sino Biological Human cDNA Clone for CCR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR1
    Sirion Biotech Customized lentivirus for stable overexpression of CCR1 
                         Customized lentivirus expression plasmids for stable overexpression of CCR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCR1
    Search LifeMap BioReagents cell lines for CCR1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCR1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    3PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    4Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCR1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCR1 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 BioSystems Pathways for CCR1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    5/8        Reactome Pathways for CCR1 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR


    2         Kegg Pathways  (Kegg details for CCR1):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    CCR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/192 Interacting proteins for CCR1 (P322461, 3 ENSP000002961404) via UniProtKB, MINT, STRING, and/or I2D (see all 192)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLP2Q049411, 3, ENSP000003655054EBI-608322,EBI-608347 I2D: score=4 STRING: ENSP00000365505
    CREB3O43889-21, ENSP000003421364EBI-608322,EBI-625022 I2D: score=2 STRING: ENSP00000342136
    CCL3L3P166193, ENSP000003676054I2D: score=3 STRING: ENSP00000367605
    CCL7P800983, ENSP000002003074I2D: score=4 STRING: ENSP00000200307
    CCL2P135003, ENSP000002258314I2D: score=3 STRING: ENSP00000225831
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002407dendritic cell chemotaxis TAS16621978
    GO:0006816calcium ion transport IDA10734056
    GO:0006874cellular calcium ion homeostasis IDA10734056
    GO:0006887exocytosis IDA10734056
    GO:0006935chemotaxis NAS15474493

    CCR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CCR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    1 HMDB Compound for CCR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/21 IUPHAR Ligands for CCR1 (CCR1) (see all 21)    About this table 
    LigandTypeActionAffinityPubmed IDs
    CCL3
    AgonistFull agonist7.8 - 10.212381680 9624164 8530354 11170631
    [125I]CCL2
    AgonistFull agonist9.49336350
    [125I]CCL7 (human)
    AgonistFull agonist9.27545673
    BX 471
    AntagonistAntagonist8.2 - 910748002
    CCL23
    AgonistFull agonist8.912381680
    [125I]CCL3 (human)
    AgonistFull agonist8 - 8.89336350 9115216 7545673
    BP-CCL3
    AgonistFull agonist8.811170631
    2b-1
    AntagonistAntagonist8.712614873
    [125I]CCL8 (human)
    AgonistFull agonist8.39115216
    [125I]CCL5 (human)
    AgonistFull agonist8.29336350

    10/28 Novoseek inferred chemical compound relationships for CCR1 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 92.6 148 11903822 (4), 8521958 (3), 10713092 (3), 14964455 (3) (see all 90)
    ccl3 90.6 55 16197470 (5), 12651617 (3), 16284949 (3), 17298994 (2) (see all 33)
    bx471 85.3 8 17234893 (3), 15716328 (2), 17312463 (1), 12958070 (1) (see all 5)
    ccl4 63.9 13 12651617 (1), 15848520 (1), 19127964 (1), 19383907 (1) (see all 10)
    mdms 57.8 1 16741883 (1)
    calcium 50.1 26 16365449 (2), 8955214 (1), 9632350 (1), 12529679 (1) (see all 23)
    shikonin 45 6 11360924 (4), 12936978 (1)
    piperidine 34.5 1 12574358 (1)
    glycosaminoglycan 12.9 2 10766793 (1)
    cycloheximide 7.37 6 17389578 (1), 15067079 (1)

    Search CenterWatch for drugs/clinical trials and news about CCR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCR1 gene: 
    NM_001295.2  

    Unigene Cluster for CCR1:

    Chemokine (C-C motif) receptor 1
    Hs.301921  [show with all ESTs]
    Unigene Representative Sequence: NM_001295
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296140(uc003cph.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CCR1:
    hsa-miR-221* hsa-miR-511 hsa-miR-129-3p hsa-miR-129* hsa-miR-548aa
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CCR1 (NM_001295)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR1
    Sirion Biotech Customized lentivirus for stable overexpression of CCR1 
                         Customized lentivirus expression plasmids for stable overexpression of CCR1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CCR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCR1

    Additional mRNA sequence: 

    BC051306.1 BC064991.1 BT019908.1 BT019909.1 D10925.1 L09230.1 L10918.1 

    3 DOTS entries:

    DT.443651  DT.120855622  DT.75140407 

    24/90 AceView cDNA sequences (see all 90):

    AI373605 BI963080 BE326886 AI690129 BC064991 BM917063 BM917763 AI279301 
    BI962916 CK903574 BE220875 AL552677 BC051306 AI423006 CA309864 AI421071 
    CR609171 AI580333 BF115835 AI335823 BF438487 BE670754 AI358976 AI271823 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCR1 expression in normal human tissues (normalized intensities)      CCR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTGTTCT
    CCR1 Expression
    About this image


    CCR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Eosinophils Peripheral Blood
             monocytes   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Periosteum
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros

    See CCR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCR1

    SOURCE GeneReport for Unigene cluster: Hs.301921

    UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246
    Tissue specificity: Widely expressed in different hematopoietic cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCR1 (see all 13): 
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCR1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr11 , 5 chemokine (C-C motif) receptor 11, 5 77.75(n)1
    80(a)1
      9 (75.05 cM)5
    127681  NM_009912.41  NP_034042.31 
     1239621265 
    chicken
    (Gallus gallus)
    Aves CCR56
    CCR26
    C-C chemokine receptor type 2
    60(a)
    58(a)
    many ↔ many
    many ↔ many
    2(43257827-43263465)
    2(43274889-43275953)
    lizard
    (Anolis carolinensis)
    Reptilia CCR56
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    57(a)
    56(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343324.1(443935-445008)
    GL343324.1(448159-449136)


    ENSEMBL Gene Tree for CCR1 (if available)
    TreeFam Gene Tree for CCR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCR1 gene
    CCR62  CCR52  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CCR82  CXCR22  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    18/55 SIMAP similar genes for CCR1 using alignment to 2 protein entries:     CCR1_HUMAN (see all proteins) (see all similar genes):
    CCR-5    CCR3    CCR2    CCR5    CCR4    CCR8
    CX3CR1    CCR7    AGTR1    CCR6    CCRL2    XCR1
    BDKRB2    BLR1    CCBP2    CXCR1    CXCR2    CXCR3

    CCR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/341 SNPs in CCR1 are shown (see all 341)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs751353861,2
    --46182411(+) ATGTGA/TACAAT 1 -- us2k10--------
    rs31366721,2
    C,F,O,H--46242785(-) CACACA/GCCCCC 1 -- ds500116Minor allele frequency- G:0.19NA NS EA WA CSA 952
    rs1844128221,2
    --46242820(+) GTCCAA/CAAAAG 1 -- ds50010--------
    rs170787041,2
    C,F,H--46242874(+) CACCCG/ATCAGC 1 -- ds50018Minor allele frequency- A:0.03NA NS EA 674
    rs1445092091,2
    --46243109(+) CTGGGC/TTGAAC 1 -- ds50010--------
    rs31366711,2
    C,F,O,H--46243175(-) AAGTCG/ATTGGC 1 -- ds500126Minor allele frequency- A:0.14NA EA MN NS 2764
    rs1875513131,2
    C--46243290(+) GAAGTA/CCATCA 1 -- ut310--------
    rs31366701,2
    C,F,H--46243361(-) CCACTG/ATGTGC 1 -- ut31 ese312Minor allele frequency- A:0.03NA NS EA CSA WA 1254
    rs1928161821,2
    --46243533(+) GGGTCC/GTTGGT 1 -- ut310--------
    rs2017285301,2
    C--46243599(+) CTTCTC/TGGCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCR1 (46243200 - 46249887 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876734CNV Gain21882294


    Human Gene Mutation Database (HGMD): CCR1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601159    OMIM disorders: --

    20/66 diseases for CCR1 (see all 66):    About MalaCards
    immune-complex glomerulonephritis    chromoblastomycosis    mesangial proliferative glomerulonephritis    proliferative glomerulonephritis
    avian influenza    reactive arthritis    oral lichen planus    chronic granulomatous disease
    glomerulonephritis    endometriosis    hiv type 1    fibrosarcoma
    burkitt's lymphoma    lichen planus    cytomegalovirus infection    chronic myeloid leukemia
    encephalomyelitis    acute pancreatitis    severe combined immunodeficiency    celiac disease

    1 disease from the University of Copenhagen DISEASES database for CCR1:
    Multiple sclerosis

    CCR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/36 Novoseek inferred disease relationships for CCR1 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 53.3 23 17484785 (2), 14734772 (2), 17513790 (2), 17229070 (1) (see all 16)
    immunodeficiency 46.7 2 9765485 (1), 9460925 (1)
    multiple sclerosis 42.1 7 19689388 (1), 16022568 (1), 16857269 (1), 12381680 (1)
    rheumatoid arthritis 37.7 6 19689388 (1), 19017998 (1), 16022568 (1), 12909630 (1)
    endometriosis 16.9 10 15950672 (2), 17261287 (2), 19050323 (2), 16679772 (1) (see all 5)
    demyelination 15.7 1 17484785 (1)
    osteosarcoma 14.8 6 12759139 (1), 16226254 (1), 11943214 (1), 19951712 (1)
    necrosis 13.4 5 15860797 (1), 19001077 (1), 18393858 (1), 15223905 (1) (see all 5)
    tumors 10.4 15 20154287 (3), 14678997 (2), 11156420 (1), 15662971 (1) (see all 11)
    arthritis 9.95 6 17016504 (2), 17929797 (1), 16107514 (1)

    Genetic Association Database (GAD): CCR1
    Human Genome Epidemiology (HuGE) Navigator: CCR1 (18 documents)

    Export disorders for CCR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCR1 gene, integrated from 9 sources (see all 486):
    (articles sorted by number of sources associating them with CCR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. (PubMed id 7679328)1, 2, 3 Neote K.... Schall T.J. (1993)
    2. Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. (PubMed id 15001559)1, 2, 9 Ko J.... Na D.S. (2004)
    3. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PubMed id 7505609)1, 2, 9 Nomura H.... Matsushima K. (1993)
    4. Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. (PubMed id 18587271)1, 2, 9 Sung H.J....Ko J. (2008)
    5. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. (PubMed id 17135764)1, 4, 9 Nakamura H....Eboshida A. (2007)
    6. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    7. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    8. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    9. Four novel coeliac disease regions replicated in an a ssociation study of a Swedish-Norwegian family cohort. (PubMed id 19693089)1, 4 Amundsen S.S....Sollid L.M. (2010)
    10. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1230 HGNC: 1602 AceView: CCR1 Ensembl:ENSG00000163823 euGenes: HUgn1230
    ECgene: CCR1 Kegg: 1230 H-InvDB: CCR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCR1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCR1 gene:
    Search GeneIP for patents involving CCR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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