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CCR1 Gene

protein-coding   GIFtS: 67
GCID: GC03M046218

Chemokine (C-C Motif) Receptor 1


(Previous symbols: SCYAR1, CMKBR1)
  See CCR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Receptor 11 2     LD78 Receptor2 3
CMKBR11 2 3 5     CKR12 5
SCYAR11 2 3     CD1912
HM1452 3 5     CKR-12
Macrophage Inflammatory Protein 1-Alpha Receptor2 3     MIP1aR2
CC-CKR-12 3     C-C Chemokine Receptor Type 12
CCR-12 3     RANTES Receptor2
MIP-1alpha-R2 3     CMKR13
RANTES-R2 3     CD191 Antigen3
C-C CKR-12 3     

External Ids:    HGNC: 16021   Entrez Gene: 12302   Ensembl: ENSG000001638237   OMIM: 6011595   UniProtKB: P322463   

Export aliases for CCR1 gene to outside databases

Previous GC identifers: GC03M045484 GC03M046062 GC03M046204


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCR1 Gene:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane
protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory
protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte
chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their
receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of
inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from
inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes,
including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CCR1 Gene:
CCR1 (chemokine (C-C motif) receptor 1) is a protein-coding gene. Diseases associated with CCR1 include mesangial proliferative glomerulonephritis, and chromoblastomycosis. GO annotations related to this gene include C-C chemokine receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CCR5.

UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246
Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less
efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium
ions level. Responsible for affecting stem cell proliferation

summary for CCR1 Gene:
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed
migration of immune cells. Over fifty human chemokines have been identified that can be categorised into
four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine
residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface
of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are
classified according to the class of chemokines that they bind. The major function of chemokines is to
regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include
angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of
chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by
cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCR1 gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   c-Ets-1   C/EBPalpha   STAT1alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCR1 promoter sequence
   Search Chromatin IP Primers for CCR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

CCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCR1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M046218:  view genomic region     (about GC identifiers)

Start:
46,243,200 bp from pter      End:
46,249,887 bp from pter
Size:
6,688 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246 (See protein sequence)
Recommended Name: C-C chemokine receptor type 1  
Size: 355 amino acids; 41173 Da
Subunit: Interacts with CREB3
1 PDB 3D structure from and Proteopedia for CCR1:
1Y5D (3D)    
Secondary accessions: Q86VA9

Explore the universe of human proteins at neXtProt for CCR1: NX_P32246

Explore proteomics data for CCR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus

  • See CCR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001286.1  
    ENSEMBL proteins: 
     ENSP00000296140  
    Reactome Protein details: P32246

    CCR1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCR1
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CCR1

     
    Search eBioscience for Proteins for CCR1 

    CCR1 Antibody Products:

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    Browse Enzo Life Sciences for kits & assays
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    Search eBioscience for ELISAs for CCR1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CCR: GPCR / Class A : Chemokine receptors : C-C motif

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCR1
    Chemokine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002236 Chemokine_CCR1
     IPR000355 Chemokine_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32246

    ProtoNet protein and cluster: P32246

    2 Blocks protein domains:
    IPB000355 Chemokine receptor signature
    IPB002236 C-C chemokine receptor type 1 signature


    UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CCR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCR1_HUMAN, P32246
    Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less
    efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium
    ions level. Responsible for affecting stem cell proliferation
    Induction: Up-regulated by CREB3

         Genatlas biochemistry entry for CCR1:
    chemokine CC, beta,receptor 1,with high affinity binding for monocyte chemoattractant protein 3,G protein coupled
    receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity IDA10734056
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity IDA10660125
    GO:0005515protein binding IPI15001559
    GO:0016493C-C chemokine receptor activity IDA10734056
         
    Find genes that share ontologies with CCR1           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccr1):
     cardiovascular system  cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  renal/urinary system  respiratory system 

    Find genes that share phenotypes with CCR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CCR1: Ccr1tm1Gao Ccr1tm1Cge

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCR1:
    hsa-mir-21-5p (MIRT005956)

    Block miRNA regulation of human, mouse, rat CCR1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CCR1:
    hsa-miR-221* hsa-miR-511 hsa-miR-129-3p hsa-miR-129* hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidCCR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCR1
    Predesigned siRNA for gene silencing in human, mouse, rat CCR1

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CCR1 (NM_001295)
    Sino Biological Human cDNA Clone for CCR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCR1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCR1_HUMAN, P32246: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7505609
    GO:0009897external side of plasma membrane IDA10706735
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with CCR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCR1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    2Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    5Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33


    Find genes that share SuperPaths with CCR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCR1
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCR1 (see all 8)
        Chemokine Signaling
    STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling

    2 BioSystems Pathways for CCR1
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs


    2 Reactome Pathways for CCR1
        Chemokine receptors bind chemokines
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for CCR1):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR1 (see all 13): 
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCR1 (P322461, 3 ENSP000002961404) via UniProtKB, MINT, STRING, and/or I2D (see all 192)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLP2Q049411, 3, ENSP000003655054EBI-608322,EBI-608347 I2D: score=4 STRING: ENSP00000365505
    CREB3O43889-21, ENSP000003421364EBI-608322,EBI-625022 I2D: score=2 STRING: ENSP00000342136
    CCL3L3P166193, ENSP000003676054I2D: score=3 STRING: ENSP00000367605
    CCL7P800983, ENSP000002003074I2D: score=4 STRING: ENSP00000200307
    CCL2P135003, ENSP000002258314I2D: score=3 STRING: ENSP00000225831
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002407dendritic cell chemotaxis TAS16621978
    GO:0006816calcium ion transport IDA10734056
    GO:0006874cellular calcium ion homeostasis IDA10734056
    GO:0006887exocytosis IDA10734056
    GO:0006935chemotaxis NAS15474493

    Find genes that share ontologies with CCR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CCR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 504393Highly selective CCR2 chemokine receptor antagonist[300816-15-3]
    MaravirocSelective CCR5 antagonist[376348-65-1]
    SB 225002Potent and selective CXCR2 antagonist[182498-32-4]
    SB 265610Potent CXCR2 antagonist[211096-49-0]
    TC 14012CXCR4 antagonist; CXCR7 agonist[368874-34-4]

    1 HMDB Compound for CCR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for CCR1 (CCR1) (see all 21)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCL3
    AgonistFull agonist7.8 - 10.212381680 9624164 8530354 11170631
    [125I]CCL2
    AgonistFull agonist9.49336350
    [125I]CCL7 (human)
    AgonistFull agonist9.27545673
    BX 471
    AntagonistAntagonist8.2 - 910748002
    CCL23
    AgonistFull agonist8.912381680
    [125I]CCL3 (human)
    AgonistFull agonist8 - 8.89336350 9115216 7545673
    BP-CCL3
    AgonistFull agonist8.811170631
    2b-1
    AntagonistAntagonist8.712614873
    [125I]CCL8 (human)
    AgonistFull agonist8.39115216
    [125I]CCL5 (human)
    AgonistFull agonist8.29336350

    Selected Novoseek inferred chemical compound relationships for CCR1 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 92.6 148 11903822 (4), 8521958 (3), 10713092 (3), 14964455 (3) (see all 90)
    ccl3 90.6 55 16197470 (5), 12651617 (3), 16284949 (3), 17298994 (2) (see all 33)
    bx471 85.3 8 17234893 (3), 15716328 (2), 17312463 (1), 12958070 (1) (see all 5)
    ccl4 63.9 13 12651617 (1), 15848520 (1), 19127964 (1), 19383907 (1) (see all 10)
    mdms 57.8 1 16741883 (1)
    calcium 50.1 26 16365449 (2), 8955214 (1), 9632350 (1), 12529679 (1) (see all 23)
    shikonin 45 6 11360924 (4), 12936978 (1)
    piperidine 34.5 1 12574358 (1)
    glycosaminoglycan 12.9 2 10766793 (1)
    cycloheximide 7.37 6 17389578 (1), 15067079 (1)



    Find genes that share compounds with CCR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCR1 gene: 
    NM_001295.2  

    Unigene Cluster for CCR1:

    Chemokine (C-C motif) receptor 1
    Hs.301921  [show with all ESTs]
    Unigene Representative Sequence: NM_001295
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296140(uc003cph.1)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCCR1 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCR1
      QuantiTect SYBR Green Assays in human, mouse, rat CCR1
      QuantiFast Probe-based Assays in human, mouse, rat CCR1

    Additional mRNA sequence: 

    BC051306.1 BC064991.1 BT019908.1 BT019909.1 D10925.1 L09230.1 L10918.1 

    3 DOTS entries:

    DT.443651  DT.120855622  DT.75140407 

    Selected AceView cDNA sequences (see all 90):

    BF438487 BE326886 AI373605 BF115835 BM917063 BI962916 BM917763 CR609171 
    AI580333 BE670754 AI279301 CA309864 AI358976 AI271823 AI690129 BI963080 
    AI423006 AL552677 BC051306 AI421071 BE220875 CK903574 BC064991 AI335823 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTGTTCT
    CCR1 Expression
    About this image


    CCR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 7 entries
             Monocytes Peripheral Blood
             leukocytes   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod Periosteum
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    CCR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301921

    UniProtKB/Swiss-Prot: CCR1_HUMAN, P32246
    Tissue specificity: Widely expressed in different hematopoietic cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCR1 (see all 13): 
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCR1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccr11 , 5 chemokine (C-C motif) receptor 11, 5 77.75(n)1
    80(a)1
      9 (75.05 cM)5
    127681  NM_009912.41  NP_034042.31 
     1239621265 


    ENSEMBL Gene Tree for CCR1 (if available)
    TreeFam Gene Tree for CCR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCR1 gene
    CCR52  CCR62  CXCR62  ACKR42  CXCR32  XCR12  CCR92  CCRL22  
    CCR72  ACKR22  CX3CR12  CCR82  CXCR22  CCR42  CXCR12  CCR22  
    CXCR52  CCR102  CCR32  CXCR42  
    Selected SIMAP similar genes for CCR1 using alignment to 2 protein entries:     CCR1_HUMAN (see all proteins) (see all similar genes):
    CCR-5    CCR3    CCR2    CCR5    CCR4    CCR8
    CX3CR1    CCR7    AGTR1    CCR6    CCRL2    XCR1
    ACKR2    BDKRB2    BLR1    CCBP2    CXCR1    CXCR2

    Find genes that share paralogs with CCR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCR1 (see all 341)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs751353861,2
    --46182411(+) ATGTGA/TACAAT 1 -- us2k10--------
    rs31366721,2
    C,F,O,H--46242785(-) CACACA/GCCCCC 1 -- ds500116Minor allele frequency- G:0.19NA NS EA WA CSA 952
    rs1844128221,2
    --46242820(+) GTCCAA/CAAAAG 1 -- ds50010--------
    rs170787041,2
    C,F,H--46242874(+) CACCCG/ATCAGC 1 -- ds50018Minor allele frequency- A:0.03NA NS EA 674
    rs1445092091,2
    --46243109(+) CTGGGC/TTGAAC 1 -- ds50010--------
    rs31366711,2
    C,F,O,H--46243175(-) AAGTCG/ATTGGC 1 -- ds500126Minor allele frequency- A:0.14NA EA MN NS 2764
    rs1875513131,2
    C--46243290(+) GAAGTA/CCATCA 1 -- ut310--------
    rs31366701,2
    C,F,H--46243361(-) CCACTG/ATGTGC 1 -- ut31 ese312Minor allele frequency- A:0.03NA NS EA CSA WA 1254
    rs1928161821,2
    --46243533(+) GGGTCC/GTTGGT 1 -- ut310--------
    rs2017285301,2
    C--46243599(+) CTTCTC/TGGCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCR1 (46243200 - 46249887 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876734CNV Gain21882294

    Human Gene Mutation Database (HGMD): CCR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601159    OMIM disorders: --

    6 diseases for CCR1:    
    About MalaCards
    mesangial proliferative glomerulonephritis    chromoblastomycosis    aphthous stomatitis    avian influenza
    proliferative glomerulonephritis    stomatitis

    1 disease from the University of Copenhagen DISEASES database for CCR1:
    Multiple sclerosis

    Find genes that share disorders with CCR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCR1 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 53.3 23 17484785 (2), 14734772 (2), 17513790 (2), 17229070 (1) (see all 16)
    immunodeficiency 46.7 2 9765485 (1), 9460925 (1)
    multiple sclerosis 42.1 7 19689388 (1), 16022568 (1), 16857269 (1), 12381680 (1)
    rheumatoid arthritis 37.7 6 19689388 (1), 19017998 (1), 16022568 (1), 12909630 (1)
    endometriosis 16.9 10 15950672 (2), 17261287 (2), 19050323 (2), 16679772 (1) (see all 5)
    demyelination 15.7 1 17484785 (1)
    osteosarcoma 14.8 6 12759139 (1), 16226254 (1), 11943214 (1), 19951712 (1)
    necrosis 13.4 5 15860797 (1), 19001077 (1), 18393858 (1), 15223905 (1) (see all 5)
    tumors 10.4 15 20154287 (3), 14678997 (2), 11156420 (1), 15662971 (1) (see all 11)
    arthritis 9.95 6 17016504 (2), 17929797 (1), 16107514 (1)

    Genetic Association Database (GAD): CCR1
    Human Genome Epidemiology (HuGE) Navigator: CCR1 (18 documents)

    Export disorders for CCR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCR1 gene, integrated from 10 sources (see all 490):
    (articles sorted by number of sources associating them with CCR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. (PubMed id 7679328)1, 2, 3 Neote K.... Schall T.J. (Cell 1993)
    2. Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. (PubMed id 15001559)1, 2, 9 Ko J.... Na D.S. (FASEB J. 2004)
    3. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PubMed id 7505609)1, 2, 9 Nomura H.... Matsushima K. (Int. Immunol. 1993)
    4. Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2- induced cell migration. (PubMed id 18587271)1, 2, 9 Sung H.J.... Ko J. (Exp. Mol. Med. 2008)
    5. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. (PubMed id 17135764)1, 4, 9 Nakamura H....Eboshida A. (Int. Arch. Allergy Immunol. 2007)
    6. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    9. Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort. (PubMed id 19693089)1, 4 Amundsen S.S....Sollid L.M. (Genes Immun. 2010)
    10. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1230 HGNC: 1602 AceView: CCR1 Ensembl:ENSG00000163823 euGenes: HUgn1230
    ECgene: CCR1 Kegg: 1230 H-InvDB: CCR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCR1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CC_chemokine_receptors

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCR1 gene:
    Search GeneIP for patents involving CCR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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