Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCR1 Gene

Aliases for CCR1 Gene

  • Chemokine (C-C Motif) Receptor 1 2 3
  • CMKBR1 3 4 6
  • HM145 3 4 6
  • Macrophage Inflammatory Protein 1-Alpha Receptor 3 4
  • LD78 Receptor 3 4
  • MIP-1alpha-R 3 4
  • C-C CKR-1 3 4
  • CC-CKR-1 3 4
  • RANTES-R 3 4
  • SCYAR1 3 4
  • CCR-1 3 4
  • CKR1 3 6
  • C-C Chemokine Receptor Type 1 3
  • RANTES Receptor 3
  • CD191 Antigen 4
  • MIP1aR 3
  • CD191 3
  • CKR-1 3
  • CMKR1 4

External Ids for CCR1 Gene

Previous HGNC Symbols for CCR1 Gene

  • SCYAR1
  • CMKBR1

Previous GeneCards Identifiers for CCR1 Gene

  • GC03M045484
  • GC03M046062
  • GC03M046204

Summaries for CCR1 Gene

Entrez Gene Summary for CCR1 Gene

  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR1 Gene

CCR1 (Chemokine (C-C Motif) Receptor 1) is a Protein Coding gene. Diseases associated with CCR1 include chromoblastomycosis and mesangial proliferative glomerulonephritis. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR1 Gene

  • Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation

Tocris Summary for CCR1 Gene

  • Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorised into four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are classified according to the class of chemokines that they bind. The major function of chemokines is to regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR1 Gene

Genomics for CCR1 Gene

Regulatory Elements for CCR1 Gene

Genomic Location for CCR1 Gene

Start:
46,201,709 bp from pter
End:
46,208,396 bp from pter
Size:
6,688 bases
Orientation:
Minus strand

Genomic View for CCR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR1 Gene

Proteins for CCR1 Gene

  • Protein details for CCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32246-CCR1_HUMAN
    Recommended name:
    C-C chemokine receptor type 1
    Protein Accession:
    P32246
    Secondary Accessions:
    • Q86VA9

    Protein attributes for CCR1 Gene

    Size:
    355 amino acids
    Molecular mass:
    41173 Da
    Quaternary structure:
    • Interacts with CREB3.

    Three dimensional structures from OCA and Proteopedia for CCR1 Gene

neXtProt entry for CCR1 Gene

Proteomics data for CCR1 Gene at MOPED

Post-translational modifications for CCR1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCR1 Gene

Domains for CCR1 Gene

Gene Families for CCR1 Gene

HGNC:
  • CD :CD molecules
  • CCR :GPCR / Class A : Chemokine receptors : C-C motif
IUPHAR :

Suggested Antigen Peptide Sequences for CCR1 Gene

Graphical View of Domain Structure for InterPro Entry

P32246

UniProtKB/Swiss-Prot:

CCR1_HUMAN :
  • P32246
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR1: view

Function for CCR1 Gene

Molecular function for CCR1 Gene

GENATLAS Biochemistry: chemokine CC, beta,receptor 1,with high affinity binding for monocyte chemoattractant protein 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation
UniProtKB/Swiss-Prot Induction: Up-regulated by CREB3.

Gene Ontology (GO) - Molecular Function for CCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IDA 10734056
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity IDA 10660125
GO:0005515 protein binding IPI 15001559
GO:0016493 C-C chemokine receptor activity IDA 10734056
genes like me logo Genes that share ontologies with CCR1: view
genes like me logo Genes that share phenotypes with CCR1: view

Animal Models for CCR1 Gene

MGI Knock Outs for CCR1:

Animal Model Products

CRISPR Products

miRNA for CCR1 Gene

miRTarBase miRNAs that target CCR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCR1 Gene

Localization for CCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR1 Gene COMPARTMENTS Subcellular localization image for CCR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7505609
GO:0009897 external side of plasma membrane IDA 10706735
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CCR1: view

Pathways for CCR1 Gene

genes like me logo Genes that share pathways with CCR1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006816 calcium ion transport IDA 10734056
GO:0006874 cellular calcium ion homeostasis IDA 10734056
GO:0006887 exocytosis IDA 10734056
GO:0006935 chemotaxis NAS 15474493
genes like me logo Genes that share ontologies with CCR1: view

Compounds for CCR1 Gene

(5) Tocris Compounds for CCR1 Gene

Compound Action Cas Number
AMD 3100 octahydrochloride Highly selective CXCR4 antagonist [155148-31-5]
AMD 3465 hexahydrobromide Potent, selective CXCR4 antagonist [185991-07-5]
RS 504393 Highly selective CCR2 chemokine receptor antagonist [300816-15-3]
SB 225002 Potent and selective CXCR2 antagonist [182498-32-4]
SB 328437 Potent and selective CCR3 antagonist [247580-43-4]

(1) HMDB Compounds for CCR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(21) IUPHAR Ligand for CCR1 Gene

Ligand Type Action Affinity Pubmed IDs
CCL3 Agonist Full agonist 10.2
[125I]CCL2 Agonist Full agonist 9.4
[125I]CCL7 (human) Agonist Full agonist 9.2
BX 471 Antagonist Antagonist 9
CCL23 Agonist Full agonist 8.9
[125I]CCL3 (human) Agonist Full agonist 8.8
BP-CCL3 Agonist Full agonist 8.8
2b-1 Antagonist Antagonist 8.7
[125I]CCL8 (human) Agonist Full agonist 8.3
[125I]CCL5 (human) Agonist Full agonist 8.2
CCL5 Agonist Full agonist 8.2
CCL7 Agonist Full agonist 8.1
vMIP-II Antagonist Antagonist 8.1
CP-481,715 Antagonist Antagonist 8
UCB35625 Antagonist Antagonist 8
CCL15 Agonist Full agonist 7.9
CCL4 Antagonist Antagonist 7.8
CCL14 Agonist Full agonist 7.4
Flu-CCL3 Agonist Full agonist 7.1
CCL8 Agonist Agonist
CCL13 Agonist Agonist

(28) Novoseek inferred chemical compound relationships for CCR1 Gene

Compound -log(P) Hits PubMed IDs
rantes 92.6 116
ccl3 90.6 44
bx471 85.3 8
ccl4 63.9 10
mdms 57.8 1
genes like me logo Genes that share compounds with CCR1: view

Transcripts for CCR1 Gene

mRNA/cDNA for CCR1 Gene

(7) Additional mRNA sequences :
(90) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCR1 Gene

Chemokine (C-C motif) receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR1 Gene

No ASD Table

Relevant External Links for CCR1 Gene

GeneLoc Exon Structure for
CCR1
ECgene alternative splicing isoforms for
CCR1

Expression for CCR1 Gene

mRNA expression in normal human tissues for CCR1 Gene

mRNA differential expression in normal tissues according to GTEx for CCR1 Gene

This gene is overexpressed in Whole Blood (23.4) and Spleen (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCR1 Gene

SOURCE GeneReport for Unigene cluster for CCR1 Gene Hs.301921

mRNA Expression by UniProt/SwissProt for CCR1 Gene

P32246-CCR1_HUMAN
Tissue specificity: Widely expressed in different hematopoietic cells
genes like me logo Genes that share expressions with CCR1: view

In Situ Assay Products

Orthologs for CCR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCR1 35
  • 99.72 (n)
  • 99.72 (a)
CCR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
OneToMany
CCR1 35
  • 86.01 (n)
  • 84.51 (a)
CCR1 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCR1 35
  • 81.44 (n)
  • 78.69 (a)
mouse
(Mus musculus)
Mammalia Ccr1 35
  • 77.75 (n)
  • 80 (a)
Ccr1 16
Ccr1 36
  • 80 (a)
OneToMany
Ccr1l1 36
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CCR1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCR1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr1 35
  • 78.5 (n)
  • 80 (a)
Species with no ortholog for CCR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCR1 Gene

ENSEMBL:
Gene Tree for CCR1 (if available)
TreeFam:
Gene Tree for CCR1 (if available)

Paralogs for CCR1 Gene

genes like me logo Genes that share paralogs with CCR1: view

Variants for CCR1 Gene

Sequence variations from dbSNP and Humsavar for CCR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1491961 -- 46,208,857(+) CACCC(C/T)ATGCC upstream-variant-2KB
rs3053328 -- 46,208,458(+) TTCTT(-/C)TTTTT upstream-variant-2KB
rs3136663 -- 46,204,736(-) AATAA(A/G)AACAA intron-variant
rs3136664 -- 46,203,933(-) CTGCT(A/G)ACGAT synonymous-codon, reference
rs3136665 -- 46,203,079(-) GGCTT(C/T)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCR1 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294

Relevant External Links for CCR1 Gene

HapMap Linkage Disequilibrium report
CCR1
Human Gene Mutation Database (HGMD)
CCR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCR1 Gene

Disorders for CCR1 Gene

(1) University of Copenhagen DISEASES for CCR1 Gene

(36) Novoseek inferred disease relationships for CCR1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 53.3 19
immunodeficiency 46.7 2
multiple sclerosis 42.1 4
rheumatoid arthritis 37.7 4
endometriosis 16.9 8

Relevant External Links for CCR1

Genetic Association Database (GAD)
CCR1
Human Genome Epidemiology (HuGE) Navigator
CCR1
genes like me logo Genes that share disorders with CCR1: view

No data available for UniProtKB/Swiss-Prot for CCR1 Gene

Publications for CCR1 Gene

  1. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PMID: 7505609) Nomura H. … Matsushima K. (Int. Immunol. 1993) 3 4 23
  2. Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. (PMID: 15001559) Ko J. … Na D.S. (FASEB J. 2004) 3 4 23
  3. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. (PMID: 7679328) Neote K. … Schall T.J. (Cell 1993) 2 3 4
  4. Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. (PMID: 7683036) Gao J.-L. … Murphy P.M. (J. Exp. Med. 1993) 3 4
  5. [Correlations of chemokine receptor CCR1 expression with metastasis of lymph nodes in colorectal carcinoma tissues]. (PMID: 19664396) Ma J.A. … Pei H.P. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009) 3 23

Products for CCR1 Gene

Sources for CCR1 Gene

Back to Top

Content