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Aliases for CCPG1 Gene

Aliases for CCPG1 Gene

  • Cell Cycle Progression 1 2 3 5
  • Cell Cycle Progression Restoration Protein 8 3 4
  • CPR8 3 4
  • KIAA1254 4
  • CCP8 4

External Ids for CCPG1 Gene

Previous GeneCards Identifiers for CCPG1 Gene

  • GC00U916968
  • GC15M053435
  • GC15M053436
  • GC15M055647
  • GC15M032473

Summaries for CCPG1 Gene

GeneCards Summary for CCPG1 Gene

CCPG1 (Cell Cycle Progression 1) is a Protein Coding gene. An important paralog of this gene is PBXIP1.

UniProtKB/Swiss-Prot for CCPG1 Gene

  • Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCPG1 Gene

Genomics for CCPG1 Gene

Regulatory Elements for CCPG1 Gene

Promoters for CCPG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCPG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCPG1 Gene

Chromosome:
15
Start:
55,340,032 bp from pter
End:
55,408,510 bp from pter
Size:
68,479 bases
Orientation:
Minus strand

Genomic View for CCPG1 Gene

Genes around CCPG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCPG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCPG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCPG1 Gene

Proteins for CCPG1 Gene

  • Protein details for CCPG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULG6-CCPG1_HUMAN
    Recommended name:
    Cell cycle progression protein 1
    Protein Accession:
    Q9ULG6
    Secondary Accessions:
    • A0PJH3
    • A8K9T0
    • O14712
    • Q05DG4
    • Q5U5S7
    • Q8IYV8
    • Q9BY53
    • Q9HA17

    Protein attributes for CCPG1 Gene

    Size:
    757 amino acids
    Molecular mass:
    87340 Da
    Quaternary structure:
    • Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC (By similarity).
    SequenceCaution:
    • Sequence=AAB69314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15203.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH29398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA86568.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCPG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCPG1 Gene

Proteomics data for CCPG1 Gene at MOPED

Post-translational modifications for CCPG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCPG1 Gene

Domains & Families for CCPG1 Gene

Protein Domains for CCPG1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCPG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULG6

UniProtKB/Swiss-Prot:

CCPG1_HUMAN :
  • Belongs to the CCPG1 family.
Family:
  • Belongs to the CCPG1 family.
genes like me logo Genes that share domains with CCPG1: view

No data available for Gene Families for CCPG1 Gene

Function for CCPG1 Gene

Molecular function for CCPG1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

Gene Ontology (GO) - Molecular Function for CCPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CCPG1: view
genes like me logo Genes that share phenotypes with CCPG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCPG1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCPG1 Gene

Localization for CCPG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCPG1 Gene

Cytoplasmic granule membrane; Single-pass type II membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCPG1 Gene

Pathways & Interactions for CCPG1 Gene

SuperPathways for CCPG1 Gene

No Data Available

Interacting Proteins for CCPG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000403400%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000403400 for CCPG1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CCPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with CCPG1: view

No data available for Pathways by source and SIGNOR curated interactions for CCPG1 Gene

Drugs & Compounds for CCPG1 Gene

(3) Drugs for CCPG1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CCPG1: view

Transcripts for CCPG1 Gene

Unigene Clusters for CCPG1 Gene

Cell cycle progression 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCPG1 Gene

No ASD Table

Relevant External Links for CCPG1 Gene

GeneLoc Exon Structure for
CCPG1
ECgene alternative splicing isoforms for
CCPG1

Expression for CCPG1 Gene

mRNA expression in normal human tissues for CCPG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCPG1 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for CCPG1 Gene

This gene is overexpressed in NK cells (42.3), Fetal ovary (8.5), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCPG1 Gene



SOURCE GeneReport for Unigene cluster for CCPG1 Gene Hs.285051

genes like me logo Genes that share expression patterns with CCPG1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCPG1 Gene

Orthologs for CCPG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCPG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCPG1 35
  • 88.79 (n)
  • 84.62 (a)
CCPG1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCPG1 35
  • 90.16 (n)
  • 84.37 (a)
CCPG1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccpg1 35
  • 77.96 (n)
  • 71.25 (a)
Ccpg1 16
Ccpg1 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCPG1 35
  • 99.5 (n)
  • 99.38 (a)
CCPG1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccpg1 35
  • 77.03 (n)
  • 70.67 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCPG1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCPG1 35
  • 69.57 (n)
  • 61.29 (a)
CCPG1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCPG1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccpg1 35
  • 62.54 (n)
  • 55.36 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535530 35
  • 56.34 (n)
  • 51.08 (a)
PBXIP1 36
  • 43 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12312 35
Species with no ortholog for CCPG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCPG1 Gene

ENSEMBL:
Gene Tree for CCPG1 (if available)
TreeFam:
Gene Tree for CCPG1 (if available)

Paralogs for CCPG1 Gene

Paralogs for CCPG1 Gene

genes like me logo Genes that share paralogs with CCPG1: view

Variants for CCPG1 Gene

Sequence variations from dbSNP and Humsavar for CCPG1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_037063 -
VAR_037064 -
VAR_037065 -
VAR_037066 -
VAR_037067 -

Structural Variations from Database of Genomic Variants (DGV) for CCPG1 Gene

Variant ID Type Subtype PubMed ID
nsv904243 CNV Loss 21882294
nsv520799 CNV Loss 19592680
dgv437n67 CNV Loss 20364138
esv9731 CNV Loss 19470904
esv2749724 CNV Deletion 23290073
esv2663013 CNV Deletion 23128226
esv29128 CNV Loss 19812545
esv269468 CNV Insertion 20981092
nsv904244 CNV Loss 21882294

Variation tolerance for CCPG1 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCPG1 Gene

HapMap Linkage Disequilibrium report
CCPG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCPG1 Gene

Disorders for CCPG1 Gene

Relevant External Links for CCPG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCPG1

No disorders were found for CCPG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCPG1 Gene

Publications for CCPG1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (PMID: 9383053) Edwards M.C. … Elledge S.J. (Genetics 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. (PMID: 25126726) Dunlop E.A. … Tee A.R. (Autophagy 2014) 3
  5. RNAi screen indicates widespread biological function for human natural antisense transcripts. (PMID: 20957177) Faghihi M.A. … Wahlestedt C. (PLoS ONE 2010) 3

Products for CCPG1 Gene

Sources for CCPG1 Gene

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