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Aliases for CCPG1 Gene

Aliases for CCPG1 Gene

  • Cell Cycle Progression 1 2 3 5
  • Cell Cycle Progression Restoration Protein 8 3 4
  • CPR8 3 4
  • Cell Cycle Progression Protein 1 3
  • KIAA1254 4
  • CCP8 4

External Ids for CCPG1 Gene

Previous GeneCards Identifiers for CCPG1 Gene

  • GC00U916968
  • GC15M053435
  • GC15M053436
  • GC15M055647
  • GC15M032473

Summaries for CCPG1 Gene

GeneCards Summary for CCPG1 Gene

CCPG1 (Cell Cycle Progression 1) is a Protein Coding gene. An important paralog of this gene is PBXIP1.

UniProtKB/Swiss-Prot for CCPG1 Gene

  • Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

Additional gene information for CCPG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCPG1 Gene

Genomics for CCPG1 Gene

Regulatory Elements for CCPG1 Gene

Enhancers for CCPG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H055220 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6 +186.7 186653 3 FOXA2 ARID4B YY1 ZNF143 FOS ATF7 RUNX3 ZNF592 NFIL3 SSRP1 RAB27A PIGB CCPG1 GC15M056999 RSL24D1
GH15H055248 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +157.0 157038 5 FOXA2 MLX YY1 ZNF766 FOS ATF7 REST NFIL3 MIER3 ATF4 RAB27A RSL24D1 PIGB PYGO1 CCPG1 GC15M056999 GC15P055286
GH15H055288 1.7 FANTOM5 ENCODE dbSUPER 2.9 +118.9 118873 3 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 GLIS2 PIGB RAB27A RFX7 PIGBOS1 DNAAF4 CCPG1 ENSG00000276533 PIR62136
GH15H055401 1.1 ENCODE 0.7 +3.0 2951 7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 RSL24D1 RFX7 NEDD4 PYGO1 DNAAF4 C15orf65 PIGBOS1 PIGB CCPG1 GC15M056991
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCPG1 on UCSC Golden Path with GeneCards custom track

Promoters for CCPG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076826 310 2001 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3 ZHX2

Genomic Location for CCPG1 Gene

Chromosome:
15
Start:
55,340,032 bp from pter
End:
55,408,510 bp from pter
Size:
68,479 bases
Orientation:
Minus strand

Genomic View for CCPG1 Gene

Genes around CCPG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCPG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCPG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCPG1 Gene

Proteins for CCPG1 Gene

  • Protein details for CCPG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULG6-CCPG1_HUMAN
    Recommended name:
    Cell cycle progression protein 1
    Protein Accession:
    Q9ULG6
    Secondary Accessions:
    • A0PJH3
    • A8K9T0
    • O14712
    • Q05DG4
    • Q5U5S7
    • Q8IYV8
    • Q9BY53
    • Q9HA17

    Protein attributes for CCPG1 Gene

    Size:
    757 amino acids
    Molecular mass:
    87340 Da
    Quaternary structure:
    • Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC (By similarity).
    SequenceCaution:
    • Sequence=AAB69314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15203.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH29398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA86568.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCPG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCPG1 Gene

Post-translational modifications for CCPG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCPG1 Gene

Domains & Families for CCPG1 Gene

Gene Families for CCPG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CCPG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCPG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULG6

UniProtKB/Swiss-Prot:

CCPG1_HUMAN :
  • Belongs to the CCPG1 family.
Family:
  • Belongs to the CCPG1 family.
genes like me logo Genes that share domains with CCPG1: view

Function for CCPG1 Gene

Molecular function for CCPG1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

Gene Ontology (GO) - Molecular Function for CCPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25126726
genes like me logo Genes that share ontologies with CCPG1: view
genes like me logo Genes that share phenotypes with CCPG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCPG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCPG1 Gene

Localization for CCPG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCPG1 Gene

Cytoplasmic granule membrane; Single-pass type II membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCPG1: view

No data available for Subcellular locations from COMPARTMENTS for CCPG1 Gene

Pathways & Interactions for CCPG1 Gene

SuperPathways for CCPG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IMP 20957177
GO:0045787 positive regulation of cell cycle IMP 20957177
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with CCPG1: view

No data available for Pathways by source and SIGNOR curated interactions for CCPG1 Gene

Drugs & Compounds for CCPG1 Gene

(3) Drugs for CCPG1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CCPG1: view

Transcripts for CCPG1 Gene

Unigene Clusters for CCPG1 Gene

Cell cycle progression 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCPG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCPG1 Gene

No ASD Table

Relevant External Links for CCPG1 Gene

GeneLoc Exon Structure for
CCPG1
ECgene alternative splicing isoforms for
CCPG1

Expression for CCPG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCPG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCPG1 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for CCPG1 Gene

This gene is overexpressed in NK cells (42.3), Fetal ovary (8.5), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCPG1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCPG1 Gene:

CCPG1

SOURCE GeneReport for Unigene cluster for CCPG1 Gene:

Hs.285051

Evidence on tissue expression from TISSUES for CCPG1 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Skin(4)
genes like me logo Genes that share expression patterns with CCPG1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCPG1 Gene

Orthologs for CCPG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCPG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCPG1 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia CCPG1 33 34
  • 90.16 (n)
cow
(Bos Taurus)
Mammalia CCPG1 33 34
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Ccpg1 33 16 34
  • 77.96 (n)
rat
(Rattus norvegicus)
Mammalia Ccpg1 33
  • 77.03 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCPG1 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCPG1 33 34
  • 69.57 (n)
lizard
(Anolis carolinensis)
Reptilia CCPG1 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccpg1 33
  • 62.54 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100535530 33
  • 56.34 (n)
PBXIP1 34
  • 43 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12312 33
Species where no ortholog for CCPG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCPG1 Gene

ENSEMBL:
Gene Tree for CCPG1 (if available)
TreeFam:
Gene Tree for CCPG1 (if available)

Paralogs for CCPG1 Gene

Paralogs for CCPG1 Gene

genes like me logo Genes that share paralogs with CCPG1: view

Variants for CCPG1 Gene

Sequence variations from dbSNP and Humsavar for CCPG1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000026981 -- 55,364,787(+) AGAAT(C/T)GCTTG intron-variant
rs1000204296 -- 55,357,084(+) TGATA(A/G)ATATA intron-variant, utr-variant-3-prime
rs1000220301 -- 55,380,422(+) TCCCA(A/G)GTAGC intron-variant
rs1000232796 -- 55,369,192(+) AAAAC(A/G)GCTCT intron-variant
rs1000233727 -- 55,358,472(+) CTTCA(C/T)GGTCT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCPG1 Gene

Variant ID Type Subtype PubMed ID
dgv1216n106 CNV deletion 24896259
dgv437n67 CNV loss 20364138
dgv4544n54 CNV loss 21841781
dgv4545n54 CNV loss 21841781
dgv4546n54 CNV loss 21841781
dgv4547n54 CNV loss 21841781
esv2663013 CNV deletion 23128226
esv2749724 CNV deletion 23290073
esv2761899 CNV gain+loss 21179565
esv29128 CNV loss 19812545
esv3390087 CNV insertion 20981092
esv3552487 CNV deletion 23714750
esv3569598 CNV gain 25503493
esv3636557 CNV loss 21293372
esv3636558 CNV loss 21293372
esv3636560 CNV loss 21293372
esv3636562 CNV loss 21293372
esv9731 CNV loss 19470904
nsv1043789 CNV gain 25217958
nsv475201 CNV novel sequence insertion 20440878
nsv520799 CNV loss 19592680
nsv569523 CNV gain 21841781
nsv569530 CNV loss 21841781

Variation tolerance for CCPG1 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCPG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCPG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCPG1 Gene

Disorders for CCPG1 Gene

Relevant External Links for CCPG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCPG1

No disorders were found for CCPG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCPG1 Gene

Publications for CCPG1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  2. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (PMID: 9383053) Edwards MC … Elledge SJ (Genetics 1997) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for CCPG1 Gene

Sources for CCPG1 Gene

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