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Aliases for CCPG1 Gene

Aliases for CCPG1 Gene

  • Cell Cycle Progression 1 2 3
  • Cell Cycle Progression Restoration Protein 8 3 4
  • CPR8 3 4
  • Cell Cycle Progression Protein 1 3
  • KIAA1254 4
  • CCP8 4

External Ids for CCPG1 Gene

Previous GeneCards Identifiers for CCPG1 Gene

  • GC00U916968
  • GC15M053435
  • GC15M053436
  • GC15M055647
  • GC15M032473

Summaries for CCPG1 Gene

GeneCards Summary for CCPG1 Gene

CCPG1 (Cell Cycle Progression 1) is a Protein Coding gene. An important paralog of this gene is PBXIP1.

UniProtKB/Swiss-Prot for CCPG1 Gene

  • Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCPG1 Gene

Genomics for CCPG1 Gene

Regulatory Elements for CCPG1 Gene

Genomic Location for CCPG1 Gene

Start:
55,340,032 bp from pter
End:
55,408,510 bp from pter
Size:
68,479 bases
Orientation:
Minus strand

Genomic View for CCPG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCPG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCPG1 Gene

Proteins for CCPG1 Gene

  • Protein details for CCPG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULG6-CCPG1_HUMAN
    Recommended name:
    Cell cycle progression protein 1
    Protein Accession:
    Q9ULG6
    Secondary Accessions:
    • A0PJH3
    • A8K9T0
    • O14712
    • Q05DG4
    • Q5U5S7
    • Q8IYV8
    • Q9BY53
    • Q9HA17

    Protein attributes for CCPG1 Gene

    Size:
    757 amino acids
    Molecular mass:
    87340 Da
    Quaternary structure:
    • Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC (By similarity).
    SequenceCaution:
    • Sequence=AAB69314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15203.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH29398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA86568.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCPG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCPG1 Gene

Proteomics data for CCPG1 Gene at MOPED

Post-translational modifications for CCPG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCPG1 Gene

Domains for CCPG1 Gene

Protein Domains for CCPG1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCPG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULG6

UniProtKB/Swiss-Prot:

CCPG1_HUMAN :
  • Q9ULG6
Family:
  • Belongs to the CCPG1 family.
genes like me logo Genes that share domains with CCPG1: view

No data available for Gene Families for CCPG1 Gene

Function for CCPG1 Gene

Molecular function for CCPG1 Gene

UniProtKB/Swiss-Prot Function: Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

Gene Ontology (GO) - Molecular Function for CCPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CCPG1: view

Phenotypes for CCPG1 Gene

genes like me logo Genes that share phenotypes with CCPG1: view

miRNA for CCPG1 Gene

miRTarBase miRNAs that target CCPG1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCPG1 Gene

Localization for CCPG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCPG1 Gene

Cytoplasmic granule membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCPG1 Gene COMPARTMENTS Subcellular localization image for CCPG1 gene
Compartment Confidence
nucleus 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCPG1: view

Pathways for CCPG1 Gene

SuperPathways for CCPG1 Gene

No Data Available

Interacting Proteins for CCPG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000403400%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000403400 for CCPG1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CCPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IMP 20957177
GO:0045787 positive regulation of cell cycle IMP 20957177
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with CCPG1: view

No data available for Pathways by source for CCPG1 Gene

Compounds for CCPG1 Gene

(3) HMDB Compounds for CCPG1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with CCPG1: view

Transcripts for CCPG1 Gene

Unigene Clusters for CCPG1 Gene

Cell cycle progression 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCPG1 Gene

No ASD Table

Relevant External Links for CCPG1 Gene

GeneLoc Exon Structure for
CCPG1
ECgene alternative splicing isoforms for
CCPG1

Expression for CCPG1 Gene

mRNA expression in normal human tissues for CCPG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCPG1 Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCPG1 Gene

SOURCE GeneReport for Unigene cluster for CCPG1 Gene Hs.285051

genes like me logo Genes that share expressions with CCPG1: view

No data available for mRNA Expression by UniProt/SwissProt for CCPG1 Gene

Orthologs for CCPG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCPG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCPG1 35
  • 99.5 (n)
  • 99.38 (a)
CCPG1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCPG1 35
  • 88.79 (n)
  • 84.62 (a)
CCPG1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCPG1 35
  • 90.16 (n)
  • 84.37 (a)
CCPG1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccpg1 35
  • 77.96 (n)
  • 71.25 (a)
Ccpg1 16
Ccpg1 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCPG1 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccpg1 35
  • 77.03 (n)
  • 70.67 (a)
chicken
(Gallus gallus)
Aves CCPG1 35
  • 69.57 (n)
  • 61.29 (a)
CCPG1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCPG1 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccpg1 35
  • 62.54 (n)
  • 55.36 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12312 35
zebrafish
(Danio rerio)
Actinopterygii LOC100535530 35
  • 56.34 (n)
  • 51.08 (a)
PBXIP1 36
  • 43 (a)
OneToMany
Species with no ortholog for CCPG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCPG1 Gene

ENSEMBL:
Gene Tree for CCPG1 (if available)
TreeFam:
Gene Tree for CCPG1 (if available)

Paralogs for CCPG1 Gene

Paralogs for CCPG1 Gene

genes like me logo Genes that share paralogs with CCPG1: view

Variants for CCPG1 Gene

Sequence variations from dbSNP and Humsavar for CCPG1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
VAR_037063 -
VAR_037064 -
VAR_037065 -
VAR_037066 -
VAR_037067 -

Structural Variations from Database of Genomic Variants (DGV) for CCPG1 Gene

Variant ID Type Subtype PubMed ID
nsv904243 CNV Loss 21882294
nsv520799 CNV Loss 19592680
dgv437n67 CNV Loss 20364138
esv9731 CNV Loss 19470904
esv2749724 CNV Deletion 23290073
esv2663013 CNV Deletion 23128226
esv29128 CNV Loss 19812545
esv269468 CNV Insertion 20981092
nsv904244 CNV Loss 21882294

Relevant External Links for CCPG1 Gene

HapMap Linkage Disequilibrium report
CCPG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCPG1 Gene

Disorders for CCPG1 Gene

No disorders were found for CCPG1 Gene.

No data available for UniProtKB/Swiss-Prot for CCPG1 Gene

Publications for CCPG1 Gene

  1. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (PMID: 9383053) Edwards M.C. … Elledge S.J. (Genetics 1997) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promoters. (PMID: 17092945) Myslinski E. … Carbon P. (J. Biol. Chem. 2006) 3

Products for CCPG1 Gene

Sources for CCPG1 Gene

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