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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCPG1 Gene

protein-coding   GIFtS: 49
GCID: GC15M055647

cell cycle progression 1

 Explore 1 disease affiliated with
CCPG1 via our new
 Human Malady Compendium 
Biological research products
for CCPG1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cell Cycle Progression 11 2
CPR81 2 3
KIAA12541 3
Cell Cycle Progression Restoration Protein 82 3
Cell Cycle Progression Protein 12
CCP83

External Ids:    HGNC: 242271   Entrez Gene: 92362   Ensembl: ENSG000002609167   OMIM: 6113265   UniProtKB: Q9ULG63   

Export aliases for CCPG1 gene to outside databases

Previous GC identifers: GC00U916968 GC15M053435 GC15M053436 GC15M032473


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CCPG1_HUMAN, Q9ULG6
Function: Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity
of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its
transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or
CDC42 (By similarity). May be involved in cell cycle regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCPG1 gene promoter:
         CREB   AML1a   deltaCREB   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCPG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCPG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCPG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.1

CCPG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCPG1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M055647:  view genomic region     (about GC identifiers)

Start:
55,632,230 bp from pter      End:
55,700,708 bp from pter
Size:
68,479 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCPG1_HUMAN, Q9ULG6 (See protein sequence)
Recommended Name: Cell cycle progression protein 1  
Size: 757 amino acids; 87340 Da
Subunit: Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with
GTP-bound CDC42 and SRC (By similarity)
Subcellular location: Cytoplasmic granule membrane; Single-pass type II membrane protein (By similarity)
Sequence caution: Sequence=AAB69314.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH15203.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAH29398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=BAA86568.2; Type=Erroneous initiation;
Secondary accessions: A0PJH3 A8K9T0 O14712 Q05DG4 Q5U5S7 Q8IYV8 Q9BY53 Q9HA17
Alternative splicing: 5 isoforms:  Q9ULG6-1   Q9ULG6-2   Q9ULG6-3   Q9ULG6-4   Q9ULG6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCPG1: NX_Q9ULG6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULG6

  • CCPG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001191379.1  NP_001191380.1  NP_004739.3  NP_065790.2  

    ENSEMBL proteins: 
     ENSP00000457967   ENSP00000403400   ENSP00000311656   ENSP00000415128   ENSP00000455406  
     ENSP00000454666   ENSP00000455852   ENSP00000454456   ENSP00000454802   ENSP00000457393  
     ENSP00000456045  

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    Uscn Proteins for CCPG1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    CCPG1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CCPG1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024889 Ccpg1

    Graphical View of Domain Structure for InterPro Entry Q9ULG6

    ProtoNet protein and cluster: Q9ULG6

    UniProtKB/Swiss-Prot: CCPG1_HUMAN, Q9ULG6
    Similarity: Belongs to the CCPG1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CCPG1_HUMAN, Q9ULG6
    Function: Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity
    of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its
    transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or
    CDC42 (By similarity). May be involved in cell cycle regulation

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCPG1
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    hsa-miR-30c hsa-miR-576-3p hsa-miR-136 hsa-miR-30d hsa-miR-27b* hsa-miR-30a hsa-miR-629* hsa-miR-412
    SwitchGear 3'UTR luciferase reporter plasmidCCPG1 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    CCPG1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CCPG1:
     Increased number of cells in m 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCPG1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CCPG1 (ENSP000003116564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STUB1ENSP000002195484STRING: ENSP00000219548
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter ----
    GO:2001106regulation of Rho guanyl-nucleotide exchange factor activity ----


    CCPG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CCPG1

    3 HMDB Compounds for CCPG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about CCPG1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCPG1 gene (4 alternative transcripts): 
    NM_001204450.1  NM_001204451.1  NM_004748.4  NM_020739.3  

    Unigene Cluster for CCPG1:

    Cell cycle progression 1
    Hs.285051  [show with all ESTs]
    Unigene Representative Sequence: NM_004748
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564663 ENST00000563294 ENST00000442196 ENST00000310958(uc002acu.2 uc002acz.2 uc002acw.2 uc002acx.3 uc010bfk.2 uc002acv.2)
    ENST00000425574 ENST00000568543 ENST00000568592 ENST00000568372 ENST00000568808
    ENST00000569205 ENST00000563171 ENST00000570272 ENST00000564092

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    hsa-miR-30c hsa-miR-576-3p hsa-miR-136 hsa-miR-30d hsa-miR-27b* hsa-miR-30a hsa-miR-629* hsa-miR-412
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB033080.2 AF011794.1 AF212228.1 AK022459.1 AK292795.1 BC015203.1 BC027621.1 BC029398.1 
    BC034914.1 BC039871.1 BC042826.1 NR_037923.1 

    16 DOTS entries:

    DT.97789971  DT.95171373  DT.101984092  DT.95223311  DT.100837055  DT.100837050  DT.318388  DT.121055364 
    DT.91756684  DT.95368975  DT.100837054  DT.444271  DT.100837059  DT.100706958  DT.100837053  DT.95171371 

    24/287 AceView cDNA sequences (see all 287):

    CA314883 AI401619 AU122634 BQ003835 BU607643 CN479393 CB990699 AA042910 
    BU742207 BX501391 AA737972 AL705964 CF541203 AW512489 BX644295 AA319689 
    CA393432 AI064866 BQ269317 BC039871 BX485717 BP361452 BE819218 AA328847 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCPG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAACTTACCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CCPG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CCPG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCPG1

    SOURCE GeneReport for Unigene cluster: Hs.285051
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCPG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCPG1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccpg11 , 5 cell cycle progression 11, 5 76.89(n)1
    70.15(a)1
      9 (40.08 cM)5
    722781  NM_001114328.11  NP_001107800.11 
     729854295 
    chicken
    (Gallus gallus)
    Aves CCPG11 cell cycle progression 1 69.57(n)
    61.29(a)
      427496  NM_001031455.1  NP_001026626.1 
    lizard
    (Anolis carolinensis)
    Reptilia DYX1C1-CCPG16
    --
    47(a)
    1 ↔ 1
    AAWZ02037309(3649-15599)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005355301 cell cycle progression protein 1-like 55.99(n)
    50.4(a)
      100535530  XM_003201693.1  XP_003201741.1 


    ENSEMBL Gene Tree for CCPG1 (if available)
    TreeFam Gene Tree for CCPG1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCPG1 gene
    PBXIP12  
    18/23 SIMAP similar genes for CCPG1 using alignment to 8 protein entries:     CCPG1_HUMAN (see all proteins) (see all similar genes):
    COX7A2    IFT122    ZNF568    KLHDC1    MKRN1    ZNF23
    ATL2    LRRC36    NDUFS7    FANCA    PSD3    LRTOMT
    NSD1    SENP7    C12orf23    C11orf80    ZNHIT3    BUB1B

    CCPG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1101 NCBI SNPs in CCPG1 are shown (see all 1101    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865728071,2
    --55646961(+) GTTTTA/TCTTGT 6 -- int1 ds50010--------
    rs1918609921,2
    --55646985(+) ACTTTC/TCTTTT 6 -- ds5001 int10--------
    rs80392241,2
    C,F,--55647227(+) CCCAGG/CTTTAG 6 -- ds5001 int16Minor allele frequency- C:0.37WA CSA NA 244
    rs24440411,2
    C,F,--55647463(+) TTACTT/CAAACA 6 -- int1 nc-transcript-variantut311Minor allele frequency- C:0.08WA 118
    rs1912189111,2
    --55647690(+) TACTTC/TGGTAA 6 -- ut31 nc-transcript-variant0--------
    rs117321,2
    C,F,O,A,H,--55647786(+) CACATA/GGTATA 6 -- ut31 nc-transcript-variant23Minor allele frequency- G:0.19MN NA NS EA WA CSA 2444
    rs1430421031,2
    --55647954(+) TCAGAA/GGGCTC 6 -- ds5001 ut31 nc-transcript-variant0--------
    rs734216191,2
    C,--55647960(+) GGCTCT/CTGAAC 6 -- nc-transcript-variantut31 ds50012Minor allele frequency- C:0.02WA 120
    rs752494171,2
    --55648106(+) AGCTTG/ACTTTA 6 -- ds5001 ut31 nc-transcript-variant1Minor allele frequency- A:0.01WA 118
    rs1482160681,2
    --55648156(+) ATCTGG/TTGCAT 6 -- ut31 nc-transcript-variantds50010--------

    HapMap Linkage Disequilibrium report for CCPG1 (55632230 - 55700708 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CCPG1
         2 CNVs: 66809 61448

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCPG1 for disorders           About GeneDecksing

    OMIM gene information: 611326    OMIM disorders: --

    1 disease for CCPG1:    About MalaCards
    herpes simplex


    Export disorders for CCPG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCPG1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CCPG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (PubMed id 9383053)1, 2, 3 Edwards M.C.... Elledge S.J. (1997)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    6. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promoters. (PubMed id 17092945)1 Myslinski E....Carbon P. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9236 HGNC: 24227 AceView: CCPG1 Ensembl:ENSG00000260916 euGenes: HUgn9236
    ECgene: CCPG1 H-InvDB: CCPG1

    (According to HUGE)
    About This Section
    HUGE: KIAA1254

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCPG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCPG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCPG1 gene:
    Search GeneIP for patents involving CCPG1

    GeneCards and IP:
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