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Aliases for CCP110 Gene

Aliases for CCP110 Gene

  • Centriolar Coiled-Coil Protein 110kDa 2 3 5
  • Centriolar Coiled Coil Protein 110kDa 2 3
  • Centrosomal Protein Of 110 KDa 3 4
  • Cep110 3 4
  • CP110 3 4
  • Centrosomal Protein CP110 3
  • KIAA0419 4

External Ids for CCP110 Gene

Summaries for CCP110 Gene

GeneCards Summary for CCP110 Gene

CCP110 (Centriolar Coiled-Coil Protein 110kDa) is a Protein Coding gene. Diseases associated with CCP110 include spinocerebellar ataxia 11. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for CCP110 Gene

  • Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.

Gene Wiki entry for CCP110 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCP110 Gene

Genomics for CCP110 Gene

Regulatory Elements for CCP110 Gene

Promoters for CCP110 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCP110 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCP110 Gene

Chromosome:
16
Start:
19,523,811 bp from pter
End:
19,553,408 bp from pter
Size:
29,598 bases
Orientation:
Plus strand

Genomic View for CCP110 Gene

Genes around CCP110 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCP110 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCP110 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCP110 Gene

Proteins for CCP110 Gene

  • Protein details for CCP110 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43303-CP110_HUMAN
    Recommended name:
    Centriolar coiled-coil protein of 110 kDa
    Protein Accession:
    O43303
    Secondary Accessions:
    • B7WP23
    • O43335
    • Q68DV9
    • Q8NE13

    Protein attributes for CCP110 Gene

    Size:
    1012 amino acids
    Molecular mass:
    113424 Da
    Quaternary structure:
    • Interacts with CALM1, CETN2, CEP76 and CEP97. Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to centrioles. Interacts with USP20 and USP33.
    SequenceCaution:
    • Sequence=BAA24849.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCP110 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCP110 Gene

Proteomics data for CCP110 Gene at MOPED

Post-translational modifications for CCP110 Gene

  • Phosphorylated by CDKs.
  • Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate.
  • Ubiquitination at Lys 639, Lys 648, Lys 844, Lys 917, and Lys 940
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCP110 (CP110)

No data available for DME Specific Peptides for CCP110 Gene

Domains & Families for CCP110 Gene

Protein Domains for CCP110 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCP110 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCP110: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCP110 Gene

Function for CCP110 Gene

Molecular function for CCP110 Gene

UniProtKB/Swiss-Prot Function:
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
UniProtKB/Swiss-Prot Induction:
Up-regulated during the transition from G1 to S phase of the cell cycle. The highest levels are observed in S phase, after which the levels decrease markedly.

Phenotypes for CCP110 Gene

GenomeRNAi human phenotypes for CCP110:
genes like me logo Genes that share phenotypes with CCP110: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCP110 Gene

Localization for CCP110 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCP110 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCP110 Gene COMPARTMENTS Subcellular localization image for CCP110 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for CCP110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with CCP110: view

Pathways & Interactions for CCP110 Gene

genes like me logo Genes that share pathways with CCP110: view

Gene Ontology (GO) - Biological Process for CCP110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051298 centrosome duplication IMP 12361598
genes like me logo Genes that share ontologies with CCP110: view

No data available for SIGNOR curated interactions for CCP110 Gene

Drugs & Compounds for CCP110 Gene

No Compound Related Data Available

Transcripts for CCP110 Gene

Unigene Clusters for CCP110 Gene

Centriolar coiled coil protein 110kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCP110 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for CCP110 Gene

GeneLoc Exon Structure for
CCP110
ECgene alternative splicing isoforms for
CCP110

Expression for CCP110 Gene

mRNA expression in normal human tissues for CCP110 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCP110 Gene

This gene is overexpressed in Testis (25.8), Platelet (16.3), Kidney (11.2), and Fetal Brain (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCP110 Gene



SOURCE GeneReport for Unigene cluster for CCP110 Gene Hs.279912

mRNA Expression by UniProt/SwissProt for CCP110 Gene

O43303-CP110_HUMAN
Tissue specificity: Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with CCP110: view

Protein tissue co-expression partners for CCP110 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCP110 Gene

Orthologs for CCP110 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCP110 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCP110 35
  • 89.35 (n)
  • 83.38 (a)
CCP110 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCP110 35
  • 89.81 (n)
  • 84.37 (a)
CCP110 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccp110 35
  • 80.85 (n)
  • 73.63 (a)
Ccp110 16
Ccp110 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCP110 35
  • 99.37 (n)
  • 98.62 (a)
CCP110 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccp110 35
  • 81.04 (n)
  • 73.8 (a)
oppossum
(Monodelphis domestica)
Mammalia CCP110 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCP110 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCP110 35
  • 65.43 (n)
  • 56.67 (a)
CCP110 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCP110 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccp110 35
  • 54.58 (n)
  • 41.29 (a)
Str.16736 35
zebrafish
(Danio rerio)
Actinopterygii CCP110 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7045 36
  • 19 (a)
OneToOne
Species with no ortholog for CCP110:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCP110 Gene

ENSEMBL:
Gene Tree for CCP110 (if available)
TreeFam:
Gene Tree for CCP110 (if available)

Paralogs for CCP110 Gene

Pseudogenes.org Pseudogenes for CCP110 Gene

genes like me logo Genes that share paralogs with CCP110: view

No data available for Paralogs for CCP110 Gene

Variants for CCP110 Gene

Sequence variations from dbSNP and Humsavar for CCP110 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs226891 - 19,536,425(+) AGTAT(C/G)AACAG reference, missense
rs7190666 - 19,536,794(+) AAAAT(A/G)CACCG reference, missense
rs16972129 - 19,532,481(+) GCAAG(A/C)AAGCA reference, missense
rs3751821 - 19,536,181(+) TTCTC(C/T)GAAGC reference, missense
rs11645625 - 19,536,708(+) CCACT(A/T)TTGTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CCP110 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833163 CNV Gain 17160897

Variation tolerance for CCP110 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.25; 88.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCP110 Gene

HapMap Linkage Disequilibrium report
CCP110

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCP110 Gene

Disorders for CCP110 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCP110 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinocerebellar ataxia 11
  • spinocerebellar ataxia type 11
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CCP110

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCP110
genes like me logo Genes that share disorders with CCP110: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCP110 Gene

Publications for CCP110 Gene

  1. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. (PMID: 16760425) Tsang W.Y. … Dynlacht B.D. (Mol. Biol. Cell 2006) 2 3 4 67
  2. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. (PMID: 12361598) Chen Z. … Dynlacht B.D. (Dev. Cell 2002) 2 3
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3
  4. Centrin2 regulates CP110 removal in primary cilium formation. (PMID: 25753040) Prosser S.L. … Morrison C.G. (J. Cell Biol. 2015) 3
  5. CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110. (PMID: 25808870) Hu S. … Dmitrovsky E. (Cancer Res. 2015) 3

Products for CCP110 Gene

Sources for CCP110 Gene

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