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CCP110 Gene

protein-coding   GIFtS: 51
GCID: GC16P019536

Centriolar Coiled Coil Protein 110kDa

  Search for CCP110
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centriolar Coiled Coil Protein 110kDa1 2     KIAA04193 5
CP1102 3 5     Centriolar Coiled-Coil Protein Of 110 KDa2
Centrosomal Protein Of 110 KDa2 3     Centrosomal Protein CP1102
Cep1102 3     CEP1103

External Ids:    HGNC: 243421   Entrez Gene: 97382   Ensembl: ENSG000001035407   OMIM: 6095445   UniProtKB: O433033   

Export aliases for CCP110 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCP110 Gene:
CCP110 (centriolar coiled coil protein 110kDa) is a protein-coding gene.

UniProtKB/Swiss-Prot: CP110_HUMAN, O43303
Function: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key
negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing
cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome
stability via cooperation with CALM1 and CETN2

Gene Wiki entry for CCP110 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CCP110
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCP110 promoter sequence
   Search Chromatin IP Primers for CCP110

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCP110


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

CCP110 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCP110 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P019536:  view genomic region     (about GC identifiers)

Start:
19,535,133 bp from pter      End:
19,564,730 bp from pter
Size:
29,598 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP110_HUMAN, O43303 (See protein sequence)
Recommended Name: Centriolar coiled-coil protein of 110 kDa  
Size: 1012 amino acids; 113424 Da
Subunit: Interacts with CALM1, CETN2, CEP76 and CEP97. Interacts with NEURL4 and CCNF; these interactions are not
mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its
interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to
centrioles. Interacts with USP20 and USP33
Sequence caution: Sequence=BAA24849.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7WP23 O43335 Q68DV9 Q8NE13
Alternative splicing: 2 isoforms:  O43303-1   O43303-2   

Explore the universe of human proteins at neXtProt for CCP110: NX_O43303

Explore proteomics data for CCP110 at MOPED

Post-translational modifications: 

  • Phosphorylated by CDKs1
  • Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing
    centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the
    period which centrioles duplicate and elongate1
  • Ubiquitination2 at Lys639, Lys648, Lys844, Lys917, Lys940
  • Modification sites at PhosphoSitePlus

  • See CCP110 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001185951.1  NP_055526.3  

    ENSEMBL proteins: 
     ENSP00000379515   ENSP00000370803   ENSP00000454514   ENSP00000458123   ENSP00000459410  
     ENSP00000379511  
    Reactome Protein details: O43303

    CCP110 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: O43303


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP110_HUMAN, O43303
    Function: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key
    negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing
    cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome
    stability via cooperation with CALM1 and CETN2
    Induction: Up-regulated during the transition from G1 to S phase of the cell cycle. The highest levels are
    observed in S phase, after which the levels decrease markedly

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12361598
         
    Find genes that share ontologies with CCP110           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCP110
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    miRNA
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    hsa-mir-193b-3p (MIRT016275), hsa-mir-129-2-3p (MIRT006725)

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    Selected qRT-PCR Assays for microRNAs that regulate CCP110 (see all 40):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-3651 hsa-miR-218 hsa-miR-3658 hsa-miR-520g hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCP110 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP110_HUMAN, O43303: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
    Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by
    KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005814centriole IDA17681131
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CCP110           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCP110 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32


    Find genes that share SuperPaths with CCP110           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CCP110
        Cell Cycle / Checkpoint Control


    4 Reactome Pathways for CCP110
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Loss of Nlp from mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCP110
    Interactions:

        Search GeneGlobe Interaction Network for CCP110

    Selected Interacting proteins for CCP110 (O433031, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEURL4Q96JN81, 2EBI-1566217,EBI-1053406 MINT-8396480 MINT-8396863 MINT-8396954 MINT-8396999 MINT-8396578 MINT-8396972 MINT-8396494 MINT-8396768 MINT-8396653 MINT-8396896 MINT-8396594 MINT-8396414
    CEP97Q8IW351, 2, 3EBI-1566217,EBI-1566210 MINT-8396999 MINT-8396578 MINT-8396594 MINT-8396494 MINT-8396609 I2D: score=3 
    CALM1P621581, 3EBI-1566217,EBI-397435 I2D: score=3 
    CALM2P621581, 3EBI-1566217,EBI-397435 I2D: score=3 
    CALM3P621581, 3EBI-1566217,EBI-397435 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007099centriole replication IMP16244668
    GO:0030030cell projection organization IEA--
    GO:0032465regulation of cytokinesis IMP16760425

    Find genes that share ontologies with CCP110           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCP110 (CP110)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCP110 gene (2 alternative transcripts): 
    NM_001199022.1  NM_014711.4  

    Unigene Cluster for CCP110:

    Centriolar coiled coil protein 110kDa
    Hs.279912  [show with all ESTs]
    Unigene Representative Sequence: NM_014711
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396212(uc002dgk.4) ENST00000381396(uc002dgl.4) ENST00000569190(uc002dgj.3)
    ENST00000565376 ENST00000573412 ENST00000562083 ENST00000561888 ENST00000566523
    ENST00000562616 ENST00000567451 ENST00000396208
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CCP110 (see all 40):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-3651 hsa-miR-218 hsa-miR-3658 hsa-miR-520g hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCP110 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CCP110
      QuantiFast Probe-based Assays in human, mouse, rat CCP110

    Additional mRNA sequence: 

    AB007879.1 AK300426.1 AK309196.1 BC030223.1 BC034140.1 BC036654.2 CR749255.1 

    13 DOTS entries:

    DT.92423422  DT.312302  DT.100776034  DT.97819915  DT.91665210  DT.91839936  DT.92423423  DT.120655487 
    DT.102828245  DT.120655491  DT.40121827  DT.95132520  DT.92021983 

    Selected AceView cDNA sequences (see all 117):

    AW021147 AL120161 AL705345 AB007879 BQ632514 AW512972 BQ632809 AL705235 
    AI129176 AL043539 AI698739 BX643257 BQ720815 AA987370 AU123761 BI492093 
    BQ423812 AI245492 BQ425942 BF589922 BM978900 AL119036 NM_014711 AA827980 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCP110 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                                                                                                                                      
    SP2:                                                                                                                                      -               
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for CCP110

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCP110 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGAATGA
    CCP110 Expression
    About this image


    CCP110 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    CCP110 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCP110 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279912

    UniProtKB/Swiss-Prot: CP110_HUMAN, O43303
    Tissue specificity: Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small
    intestine, colon and peripheral blood leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCP110

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCP110 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccp1101 , 5 RIKEN cDNA 6330503K22 gene5
    centriolar coiled coil protein 1101
    80.85(n)1
    73.63(a)1
      7 (63.58 cM)5
    1015651  NM_182995.11  NP_892040.11 
     1187125525 
    chicken
    (Gallus gallus)
    Aves CCP1101 centriolar coiled coil protein 110kDa 65.43(n)
    56.67(a)
      416613  XM_003642124.2  XP_003642172.2 
    lizard
    (Anolis carolinensis)
    Reptilia CCP1106
    centriolar coiled coil protein 110kDa
    48(a)
    1 ↔ 1
    GL344150.1(40240-65213)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.167362 Transcribed sequence with moderate similarity to protein more 77.33(n)    AL883921.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CCP1106
    centriolar coiled coil protein 110kDa
    31(a)
    1 ↔ 1
    3(13526942-13543059) ENSDARG00000086359


    ENSEMBL Gene Tree for CCP110 (if available)
    TreeFam Gene Tree for CCP110 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCP110 gene

    Find genes that share paralogs with CCP110           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCP110
    PGOHUM00000259104


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCP110 (see all 604)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735277051,2
    C,F--19535500(+) CTGAGG/AGCGGG 2 -- int13Minor allele frequency- A:0.06WA CSA 122
    rs80578471,2
    C,F,H--19535538(+) CCCCCT/CGGAAA 2 -- int18Minor allele frequency- C:0.16NS EA WA NA 766
    rs1130078111,2
    C,F--19535625(+) GCCTGG/CAGGGC 2 -- int11Minor allele frequency- C:0.50WA 2
    rs1820989901,2
    --19535681(+) TGGGGA/CGCTGG 2 -- int10--------
    rs22856591,2
    C,F,A,H--19535692(+) GGAGAG/AGGCAG 2 -- int1 trp314Minor allele frequency- A:0.17NS EA NA WA CSA 784
    rs760328091,2
    C--19535783(+) TTCTCA/CCTCCC 2 -- int10--------
    rs1850226671,2
    C--19535966(+) CTTTGA/GTTCTA 2 -- int10--------
    rs766183481,2
    C,F--19536074(+) GGAAGC/TCGTTG 2 -- int11Minor allele frequency- T:0.03EA 120
    rs1378939861,2
    --19536106(+) GTTTCA/GTTTGA 2 -- int10--------
    rs1433248371,2
    --19536173(+) AAAAAC/TCGTCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for CCP110 (19535133 - 19564730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCP110:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436835CNV Insertion17901297
    nsv833163CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCP110
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609544    OMIM disorders: --


    Find genes that share disorders with CCP110           About GenesLikeMe


    Export disorders for CCP110 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCP110 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with CCP110)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. (PubMed id 16760425)1, 2, 3 Tsang W.Y.... Dynlacht B.D. (Mol. Biol. Cell 2006)
    2. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. (PubMed id 12361598)1, 2, 3 Chen Z.... Dynlacht B.D. (Dev. Cell 2002)
    3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1997)
    4. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. (PubMed id 23486064)1, 2 Li J.... Dynlacht B.D. (Nature 2013)
    5. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. (PubMed id 22441691)1, 2 Li J....Dynlacht B.D. (EMBO Rep. 2012)
    6. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1, 2 Al-Hakim A.K.... Pelletier L. (Mol. Cell. Proteomics 2012)
    7. Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. (PubMed id 21620453)1, 2 Kobayashi T.... Dynlacht B.D. (Cell 2011)
    8. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. (PubMed id 20596027)1, 2 D'Angiolella V.... Pagano M. (Nature 2010)
    9. Cep76, a centrosomal protein that specifically restrains centriole reduplication. (PubMed id 19460342)1, 2 Tsang W.Y.... Dynlacht B.D. (Dev. Cell 2009)
    10. Cep97 and CP110 suppress a cilia assembly program. (PubMed id 17719545)1, 2 Spektor A.... Dynlacht B.D. (Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9738 HGNC: 24342 AceView: CP110 Ensembl:ENSG00000103540 euGenes: HUgn9738
    ECgene: CCP110 H-InvDB: CCP110

    (According to HUGE)
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    HUGE: KIAA0419

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCP110 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCP110 gene:
    Search GeneIP for patents involving CCP110

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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