Aliases for CCP110 Gene
GeneCards Summary for CCP110 Gene
CCP110 (Centriolar Coiled-Coil Protein 110) is a Protein Coding gene. Diseases associated with CCP110 include Spinocerebellar Ataxia 11. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic.
UniProtKB/Swiss-Prot for CCP110 Gene
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).