CCP110 Gene

Aliases
for CCP110 gene

Summaries
for CCP110 gene

Genomic Views
for CCP110 gene

RefSeq DNA sequence:

NC_000016.9  NC_018927.1  NT_010393.16  

SwitchGear Promoter luciferase reporter plasmid: CCP110 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCP110

CCP110 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P019536:  view genomic region     (about GC identifiers)

Proteins
for CCP110 gene

Explore the universe of human proteins at neXtProt for CCP110: NX_O43303

Post-translational modifications:

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	Uscn Proteins for CCP110

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

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	Cell Signaling Technology (CST) Antibodies for CCP110  (CP110)
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	Novus Biologicals CCP110 Antibody
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	Uscn Antibodies for CCP110
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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for CCP110
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCP110

Protein Domains /
Families
for CCP110 gene

ProtoNet protein and cluster: O43303

Function
for CCP110 gene

miRNA Products:		OriGene 3'-UTR Clone: CCP110 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCP110
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate CCP110 (see all 40):
		hsa-miR-323-3p hsa-miR-548j hsa-miR-3651 hsa-miR-218 hsa-miR-3658 hsa-miR-520g hsa-miR-548d-5p hsa-miR-548a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CCP110 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCP110 (see all 4) OriGene shRNA RFP: CCP110 OriGene siRNA: CCP110
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCP110

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CCP110

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCP110 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCP110 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CCP110
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCP110
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCP110

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCP110
		Search LifeMap BioReagents cell lines for CCP110

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCP110

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for CCP110 gene

	Super-pathway	contained gene-specific pathways
1	Recruitment of mitotic centrosome proteins and complexes	Centrosome maturation 1.00 Mitotic G2-G2/M phases 0.81 Recruitment of mitotic centrosome proteins and complexes 1.00 Loss of proteins required for interphase microtubule organization from the centrosome 0.78 G2/M Transition 0.83 Loss of Nlp from mitotic centrosomes 0.78
2	Cell Cycle	Cell Cycle 1.00 Cell Cycle, Mitotic 0.84
3	Cell Cycle / Checkpoint Control	Cell Cycle / Checkpoint Control 1.00

1 Cell Signaling Technology (CST) Pathway for CCP110

Cell Cycle / Checkpoint Control

5/8        Reactome Pathways for CCP110

	Centrosome maturation
	Cell Cycle
	Recruitment of mitotic centrosome proteins and complexes
	G2/M Transition
	Loss of proteins required for interphase microtubule organization from the centrosome

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for CCP110 gene

Transcripts
for CCP110 gene

Expression
for CCP110 gene

CCP110 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTGAATGA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	TestisSeminiferous TubulesSecondary Spermatocyte			Germ Cells, Male Gametocytes
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCP110 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCP110
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCP110
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCP110

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCP110

Orthologs
for CCP110 gene

Paralogs
for CCP110 gene

Paralogs for CCP110 gene

CCP110 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CCP110
PGOHUM00000259104

Genomic Variants
for CCP110 gene

10/534 NCBI SNPs in CCP110 are shown (see all 534)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1885337771,2		--	19533454(+)	GTCGGA/CCGCCC	3	--	us2k1		0	--	--	--	--
rs1404542201,2		--	19533484(+)	TTCGCA/CGCGCC	3	--	us2k1		0	--	--	--	--
rs1455518701,2		--	19533543(+)	CCCCAC/GGCTCA	3	--	us2k1		0	--	--	--	--
rs1380358871,2		--	19533581(+)	TTTCCA/GAGGTC	3	--	us2k1		0	--	--	--	--
rs1408142741,2		--	19533632(+)	GGAGGG/TATAAG	3	--	us2k1		0	--	--	--	--
rs721305621,2	C,	--	19533743(+)	GACTATCAAT/-          TCAAT	3	--	us2k1		1		CSA	2
rs667255931,2	C	--	19533746(+)	ATTCA-/ATTCA          GTTCA	3	--	us2k1		1		NA	2
rs676636491,2	C,	--	19533761(+)	ATTCAG/ATTCAG	3	--	us2k1		1		CSA	2
rs1811977581,2		--	19533819(+)	CCGGAC/TACAGT	3	--	us2k1		0	--	--	--	--
rs1871674571,2		--	19533925(+)	TACCAC/TGTCCC	3	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCP110 (19535133 - 19564730 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CCP110: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCP110

DNA2.0 Custom Variant and Variant Library Synthesis for CCP110

Disorders / Diseases
for CCP110 gene

Publications
for CCP110 gene

PubMed articles for CCP110 gene, integrated from 9 sources (see all 37): (articles sorted by number of sources associating them with CCP110)

Utopia: connect your pdf to the dynamic world of online information

1. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. (PubMed id 16760425)^{1, 2, 3} Tsang W.Y.... Dynlacht B.D. (2006)
2. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. (PubMed id 12361598)^{1, 2, 3} Chen Z.... Dynlacht B.D. (2002)
3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)^{1, 2, 3} Ishikawa K....Ohara O. (1997)
4. Neurl4, a novel daughter centriole protein, prevents f ormation of ectopic microtubule organizing centres. (PubMed id 22441691)^{1, 2} Li J....Dynlacht B.D. (2012)
5. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)^{1, 2} Al-Hakim A.K....Pelletier L. (2012)
6. Centriolar kinesin Kif24 interacts with CP110 to remo del microtubules and regulate ciliogenesis. (PubMed id 21620453)^{1, 2} Kobayashi T....Dynlacht B.D. (2011)
7. SCF(Cyclin F) controls centrosome homeostasis and mit otic fidelity through CP110 degradation. (PubMed id 20596027)^{1, 2} D'Angiolella V....Pagano M. (2010)
8. Cep76, a centrosomal protein that specifically restrains centriole reduplication. (PubMed id 19460342)^{1, 2} Tsang W.Y.... Dynlacht B.D. (2009)
9. Cep97 and CP110 suppress a cilia assembly program. (PubMed id 17719545)^{1, 2} Spektor A.... Dynlacht B.D. (2007)
10. Plk4-induced centriole biogenesis in human cells. (PubMed id 17681131)^{1, 2} Kleylein-Sohn J.... Nigg E.A. (2007)

External Searches for CCP110 gene

Genome Databases showing CCP110 gene

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Products
for CCP110 gene