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Aliases for CCP110 Gene

Aliases for CCP110 Gene

  • Centriolar Coiled-Coil Protein 110 2 3 5
  • Centrosomal Protein Of 110 KDa 3 4
  • Cep110 3 4
  • CP110 3 4
  • Centriolar Coiled-Coil Protein Of 110 KDa 3
  • Centriolar Coiled Coil Protein 110kDa 2
  • Centriolar Coiled-Coil Protein 110kDa 3
  • Centrosomal Protein CP110 3
  • KIAA0419 4

External Ids for CCP110 Gene

Summaries for CCP110 Gene

GeneCards Summary for CCP110 Gene

CCP110 (Centriolar Coiled-Coil Protein 110) is a Protein Coding gene. Diseases associated with CCP110 include Spinocerebellar Ataxia 11 and Joubert Syndrome 1. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Deubiquitination.

UniProtKB/Swiss-Prot for CCP110 Gene

  • Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).

Gene Wiki entry for CCP110 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCP110 Gene

Genomics for CCP110 Gene

Regulatory Elements for CCP110 Gene

Enhancers for CCP110 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G019523 1.3 ENCODE dbSUPER 19.4 +0.8 839 2.8 HDGF PKNOX1 FOXA2 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 CCP110 KNOP1 ENSG00000259871 GC16P019537
GH16G019554 1.1 ENCODE 19.1 +31.8 31815 2.6 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CCP110 COQ7 TMC5 KNOP1 GDE1 C16orf62 GC16M019688 GC16M019687
GH16G019520 1.7 FANTOM5 ENCODE dbSUPER 11.9 -2.2 -2170 3.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 CCP110 KNOP1 SYT17 GDE1 GC16P019512
GH16G019529 1 dbSUPER 18.1 +10.1 10105 8.2 HNRNPUL1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 MXD4 CCP110 C16orf62 RNU4-46P KNOP1 GDE1 GC16P019537
GH16G019512 1.2 Ensembl ENCODE 11.2 -10.0 -10029 1.6 HDAC1 ATF1 ZSCAN4 KLF17 SIN3A DMAP1 ZNF48 ZNF2 RAD21 YY1 CCP110 COQ7 GC16P019512 GDE1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCP110 on UCSC Golden Path with GeneCards custom track

Promoters for CCP110 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000279954 589 1601 HDGF PKNOX1 FOXA2 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1

Genomic Location for CCP110 Gene

Chromosome:
16
Start:
19,523,811 bp from pter
End:
19,553,408 bp from pter
Size:
29,598 bases
Orientation:
Plus strand

Genomic View for CCP110 Gene

Genes around CCP110 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCP110 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCP110 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCP110 Gene

Proteins for CCP110 Gene

  • Protein details for CCP110 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43303-CP110_HUMAN
    Recommended name:
    Centriolar coiled-coil protein of 110 kDa
    Protein Accession:
    O43303
    Secondary Accessions:
    • B7WP23
    • O43335
    • Q68DV9
    • Q8NE13

    Protein attributes for CCP110 Gene

    Size:
    1012 amino acids
    Molecular mass:
    113424 Da
    Quaternary structure:
    • Interacts with CALM1, CETN2, CEP76, CEP97, CEP104, CEP290, TALPID3. Seems to associate with discrete CETN2, CEP97 and CEP290-containing complexes. Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to centrioles. Interacts with USP20 and USP33.
    SequenceCaution:
    • Sequence=BAA24849.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCP110 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCP110 Gene

Post-translational modifications for CCP110 Gene

  • Phosphorylated by CDKs.
  • Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate.
  • Ubiquitination at Lys639, Lys648, Lys844, posLast=917917, and Lys940
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCP110 Gene

Domains & Families for CCP110 Gene

Protein Domains for CCP110 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCP110 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCP110: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCP110 Gene

Function for CCP110 Gene

Molecular function for CCP110 Gene

UniProtKB/Swiss-Prot Function:
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).
UniProtKB/Swiss-Prot Induction:
Up-regulated during the transition from G1 to S phase of the cell cycle. The highest levels are observed in S phase, after which the levels decrease markedly.

Gene Ontology (GO) - Molecular Function for CCP110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12361598
genes like me logo Genes that share ontologies with CCP110: view
genes like me logo Genes that share phenotypes with CCP110: view

Animal Models for CCP110 Gene

MGI Knock Outs for CCP110:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCP110 Gene

Localization for CCP110 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCP110 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact. {ECO:0000250 UniProtKB:Q7TSH4, ECO:0000269 PubMed:21620453}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCP110 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for CCP110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 12361598
GO:0005814 centriole IDA 17681131
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CCP110: view

Pathways & Interactions for CCP110 Gene

genes like me logo Genes that share pathways with CCP110: view

Pathways by source for CCP110 Gene

1 Cell Signaling Technology pathway for CCP110 Gene

Gene Ontology (GO) - Biological Process for CCP110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007099 centriole replication IMP 16244668
GO:0016579 protein deubiquitination TAS --
GO:0030030 cell projection organization IEA --
GO:0032053 ciliary basal body organization ISS --
genes like me logo Genes that share ontologies with CCP110: view

No data available for SIGNOR curated interactions for CCP110 Gene

Drugs & Compounds for CCP110 Gene

No Compound Related Data Available

Transcripts for CCP110 Gene

Unigene Clusters for CCP110 Gene

Centriolar coiled coil protein 110kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCP110 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for CCP110 Gene

GeneLoc Exon Structure for
CCP110
ECgene alternative splicing isoforms for
CCP110

Expression for CCP110 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCP110 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCP110 Gene

This gene is overexpressed in Testis (25.8), Platelet (16.3), Kidney (11.2), and Fetal Brain (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCP110 Gene



Protein tissue co-expression partners for CCP110 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCP110 Gene:

CCP110

SOURCE GeneReport for Unigene cluster for CCP110 Gene:

Hs.279912

mRNA Expression by UniProt/SwissProt for CCP110 Gene:

O43303-CP110_HUMAN
Tissue specificity: Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for CCP110 Gene

  • Nervous system(4.9)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CCP110: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCP110 Gene

Orthologs for CCP110 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCP110 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCP110 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia CCP110 34 35
  • 89.81 (n)
cow
(Bos Taurus)
Mammalia CCP110 34 35
  • 89.35 (n)
rat
(Rattus norvegicus)
Mammalia Ccp110 34
  • 81.04 (n)
mouse
(Mus musculus)
Mammalia Ccp110 34 16 35
  • 80.85 (n)
oppossum
(Monodelphis domestica)
Mammalia CCP110 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCP110 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCP110 34 35
  • 65.43 (n)
lizard
(Anolis carolinensis)
Reptilia CCP110 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccp110 34
  • 54.58 (n)
Str.16736 34
zebrafish
(Danio rerio)
Actinopterygii CCP110 35
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7045 35
  • 19 (a)
OneToOne
Species where no ortholog for CCP110 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCP110 Gene

ENSEMBL:
Gene Tree for CCP110 (if available)
TreeFam:
Gene Tree for CCP110 (if available)

Paralogs for CCP110 Gene

Pseudogenes.org Pseudogenes for CCP110 Gene

genes like me logo Genes that share paralogs with CCP110: view

No data available for Paralogs for CCP110 Gene

Variants for CCP110 Gene

Sequence variations from dbSNP and Humsavar for CCP110 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000045866 -- 19,527,046(+) CCTAA(A/T)CCCTC intron-variant
rs1000081970 -- 19,534,510(+) CTTCC(A/G)AATAT intron-variant
rs1000175799 -- 19,534,285(+) TTGGT(C/T)CATTG intron-variant
rs1000241897 -- 19,541,391(+) ACTTT(A/G)GGAGG intron-variant
rs1000446236 -- 19,527,156(+) AAATA(C/T)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCP110 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV insertion 17901297
nsv571582 CNV gain 21841781
nsv833163 CNV gain 17160897

Variation tolerance for CCP110 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.25; 88.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCP110 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCP110

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCP110 Gene

Disorders for CCP110 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCP110 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 11
  • spinocerebellar ataxia type 11
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CCP110

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCP110
genes like me logo Genes that share disorders with CCP110: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCP110 Gene

Publications for CCP110 Gene

  1. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. (PMID: 16760425) Tsang W.Y. … Dynlacht B.D. (Mol. Biol. Cell 2006) 2 3 4 64
  2. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. (PMID: 12361598) Chen Z. … Dynlacht B.D. (Dev. Cell 2002) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 64
  4. Specific CP110 phosphorylation sites mediate anaphase catastrophe after CDK2 inhibition: evidence for cooperation with USP33 knockdown. (PMID: 26304236) Hu S. … Dmitrovsky E. (Mol. Cancer Ther. 2015) 3 4 64
  5. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. (PMID: 24421332) Kobayashi T. … Dynlacht B.D. (J. Cell Biol. 2014) 3 4 64

Products for CCP110 Gene

Sources for CCP110 Gene

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