Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCP110 Gene

protein-coding   GIFtS: 52
GCID: GC16P019536

Centriolar Coiled Coil Protein 110kDa

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Centriolar Coiled Coil Protein 110kDa1 2     KIAA04193 5
CP1102 3 5     Centriolar Coiled-Coil Protein Of 110 KDa2
Centrosomal Protein Of 110 KDa2 3     Centrosomal Protein CP1102
Cep1102 3     CEP1103

External Ids:    HGNC: 243421   Entrez Gene: 97382   Ensembl: ENSG000001035407   OMIM: 6095445   UniProtKB: O433033   

Export aliases for CCP110 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCP110 Gene: 
CCP110 (centriolar coiled coil protein 110kDa) is a protein-coding gene. Diseases associated with CCP110 include protein s deficiency, and prostatitis, and among its related super-pathways are G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: CP110_HUMAN, O43303
Function: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key
negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing
cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome
stability via cooperation with CALM1 and CETN2

Gene Wiki entry for CCP110 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CCP110
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCP110 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCP110

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCP110


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

CCP110 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCP110 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P019536:  view genomic region     (about GC identifiers)

Start:
19,535,133 bp from pter      End:
19,564,730 bp from pter
Size:
29,598 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP110_HUMAN, O43303 (See protein sequence)
Recommended Name: Centriolar coiled-coil protein of 110 kDa  
Size: 1012 amino acids; 113424 Da
Subunit: Interacts with CALM1, CETN2, CEP76 and CEP97. Interacts with NEURL4 and CCNF; these interactions are not
mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its
interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to
centrioles. Interacts with USP20 and USP33
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by
KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis
Sequence caution: Sequence=BAA24849.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7WP23 O43335 Q68DV9 Q8NE13
Alternative splicing: 2 isoforms:  O43303-1   O43303-2   

Explore the universe of human proteins at neXtProt for CCP110: NX_O43303

Explore proteomics data for CCP110 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CDKs
  • UniProtKB: Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing
    centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the
    period which centrioles duplicate and elongate
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43303

  • CCP110 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCP110 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001185951.1  NP_055526.3  

    ENSEMBL proteins: 
     ENSP00000379515   ENSP00000370803   ENSP00000454514   ENSP00000458123   ENSP00000459410  
     ENSP00000379511  
    Reactome Protein details: O43303
    Human Recombinant Protein Products for CCP110: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCP110
    GenScript Custom Purified and Recombinant Proteins Services for CCP110
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCP110 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA16760425
    GO:0005814centriole IDA17681131
    GO:0005829cytosol TAS--

    CCP110 for ontologies           About GeneDecksing



    CCP110 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CCP110  (CP110)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCP110
    GenScript Custom Superior Antibodies Services for CCP110
    Novus Biologicals CCP110 Antibody
    Abcam antibodies for CCP110
    Cloud-Clone Corp. Antibodies for CCP110 
    ThermoFisher Antibodies for CCP110
    LSBio Antibodies in human, mouse, rat for CCP110 

    Assay Products for CCP110: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCP110
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCP110
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCP110 
    Cloud-Clone Corp. CLIAs for CCP110


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O43303


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP110_HUMAN, O43303
    Function: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key
    negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing
    cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome
    stability via cooperation with CALM1 and CETN2
    Induction: Up-regulated during the transition from G1 to S phase of the cell cycle. The highest levels are
    observed in S phase, after which the levels decrease markedly

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12361598
         
    CCP110 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCP110 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCP110

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCP110 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCP110 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCP110
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate CCP110 (see all 40):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-3651 hsa-miR-218 hsa-miR-3658 hsa-miR-520g hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCP110 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCP110
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCP110

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCP110
    Sirion Biotech Customized adenovirus for overexpression of CCP110

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCP110 (see all 9)
    OriGene ORF clones in mouse, rat for CCP110
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CCP110
    Sino Biological Human cDNA Clone for CCP110
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCP110
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCP110
    Sirion Biotech Customized lentivirus for stable overexpression of CCP110 
                         Customized lentivirus expression plasmids for stable overexpression of CCP110 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCP110
    Search LifeMap BioReagents cell lines for CCP110
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCP110


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCP110 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    3DNA Damage
    Cell Cycle / Checkpoint Control0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CCP110
        Cell Cycle / Checkpoint Control


    5/8        Reactome Pathways for CCP110 (see all 8)
        Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    G2/M Transition
    Loss of proteins required for interphase microtubule organization,from the centrosome



    CCP110 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCP110

    5/29 Interacting proteins for CCP110 (O433031, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEURL4Q96JN82MINT-8396480 MINT-8396863 MINT-8396954 MINT-8396999 MINT-8396578 MINT-8396972 MINT-8396494 MINT-8396768 MINT-8396653 MINT-8396896 MINT-8396594 MINT-8396414
    CEP97Q8IW351, 2, 3EBI-1566217,EBI-1566210 MINT-8396999 MINT-8396578 MINT-8396594 MINT-8396494 MINT-8396609 I2D: score=3 
    CALM1P621581, 3EBI-1566217,EBI-397435 I2D: score=3 
    CALM2P621581, 3EBI-1566217,EBI-397435 I2D: score=3 
    CALM3P621581, 3EBI-1566217,EBI-397435 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007099centriole replication IMP16244668
    GO:0030030cell projection organization IEA--
    GO:0032465regulation of cytokinesis IMP16760425

    CCP110 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCP110 (CP110)

    Search CenterWatch for drugs/clinical trials and news about CCP110 / CP110

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCP110 gene (2 alternative transcripts): 
    NM_001199022.1  NM_014711.4  

    Unigene Cluster for CCP110:

    Centriolar coiled coil protein 110kDa
    Hs.279912  [show with all ESTs]
    Unigene Representative Sequence: NM_014711
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396212(uc002dgk.4) ENST00000381396(uc002dgl.4) ENST00000569190(uc002dgj.3)
    ENST00000565376 ENST00000573412 ENST00000562083 ENST00000561888 ENST00000566523
    ENST00000562616 ENST00000567451 ENST00000396208
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCP110
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate CCP110 (see all 40):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-3651 hsa-miR-218 hsa-miR-3658 hsa-miR-520g hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCP110 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCP110
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCP110
    Clone
    Products:
         
    OriGene clones in human, mouse for CCP110 (see all 9)
    OriGene ORF clones in mouse, rat for CCP110
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CCP110
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCP110
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCP110
    Sirion Biotech Customized lentivirus for stable overexpression of CCP110 
                         Customized lentivirus expression plasmids for stable overexpression of CCP110 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCP110
    OriGene qSTAR qPCR primer pairs in human, mouse for CCP110
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCP110
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCP110
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCP110

    Additional mRNA sequence: 

    AB007879.1 AK300426.1 AK309196.1 BC030223.1 BC034140.1 BC036654.2 CR749255.1 

    13 DOTS entries:

    DT.92423422  DT.312302  DT.100776034  DT.97819915  DT.91665210  DT.91839936  DT.92423423  DT.120655487 
    DT.102828245  DT.120655491  DT.40121827  DT.95132520  DT.92021983 

    24/117 AceView cDNA sequences (see all 117):

    AI245492 AI129176 BQ720815 BQ632514 AW512972 BQ632809 BF589922 AL705345 
    AL120161 AL043539 BX643257 AW021147 AU123761 AL119036 AI698739 BQ423812 
    BM978900 BQ425942 BI492093 AL705235 AA987370 AB007879 BI713730 AU142871 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CCP110 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                                                                                                                                      
    SP2:                                                                                                                                      -               
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for CCP110

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCP110 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGAATGA
    CCP110 Expression
    About this image


    See CCP110 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCP110

    SOURCE GeneReport for Unigene cluster: Hs.279912

    UniProtKB/Swiss-Prot: CP110_HUMAN, O43303
    Tissue specificity: Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small
    intestine, colon and peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for CCP110
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCP110
    OriGene qSTAR qPCR primer pairs in human, mouse for CCP110
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCP110
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCP110
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCP110
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCP110

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCP110 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccp1101 , 5 RIKEN cDNA 6330503K22 gene5
    centriolar coiled coil protein 1101
    80.85(n)1
    73.63(a)1
      7 (63.58 cM)5
    1015651  NM_182995.11  NP_892040.11 
     1187125525 
    chicken
    (Gallus gallus)
    Aves CCP1101 centriolar coiled coil protein 110kDa 65.3(n)
    56.1(a)
      416613  XM_003642124.1  XP_003642172.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCP1106
    centriolar coiled coil protein 110kDa
    47(a)
    1 ↔ 1
    GL344150.1(40240-65213)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.167362 Transcribed sequence with moderate similarity to protein more 77.33(n)    AL883921.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CCP1106
    centriolar coiled coil protein 110kDa
    29(a)
    1 ↔ 1
    3(13526942-13543059)
    fruit fly
    (Drosophila melanogaster)
    Insecta Cp1106
    --
    17(a)
    1 ↔ 1
    X(21884237-21889294)


    ENSEMBL Gene Tree for CCP110 (if available)
    TreeFam Gene Tree for CCP110 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCP110 gene

    CCP110 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCP110
    PGOHUM00000259104


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/604 SNPs in CCP110 are shown (see all 604)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0198234
    ----see VAR_0198232 I M mis40--------
    rs735277051,2
    C,F--19535500(+) CTGAGG/AGCGGG 2 -- int13Minor allele frequency- A:0.06WA CSA 122
    rs80578471,2
    C,F,H--19535538(+) CCCCCT/CGGAAA 2 -- int18Minor allele frequency- C:0.16NS EA WA NA 766
    rs1130078111,2
    C,F--19535625(+) GCCTGG/CAGGGC 2 -- int11Minor allele frequency- C:0.50WA 2
    rs1820989901,2
    --19535681(+) TGGGGA/CGCTGG 2 -- int10--------
    rs22856591,2
    C,F,A,H--19535692(+) GGAGAG/AGGCAG 2 -- int1 trp314Minor allele frequency- A:0.17NS EA NA WA CSA 784
    rs760328091,2
    C--19535783(+) TTCTCA/CCTCCC 2 -- int10--------
    rs1850226671,2
    C--19535966(+) CTTTGA/GTTCTA 2 -- int10--------
    rs766183481,2
    C,F--19536074(+) GGAAGC/TCGTTG 2 -- int11Minor allele frequency- T:0.03EA 120
    rs1378939861,2
    --19536106(+) GTTTCA/GTTTGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for CCP110 (19535133 - 19564730 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCP110:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436835CNV Insertion17901297
    nsv833163CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCP110
    DNA2.0 Custom Variant and Variant Library Synthesis for CCP110

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609544    OMIM disorders: --

    2 diseases for CCP110:    About MalaCards
    protein s deficiency    prostatitis


    CCP110 for disorders           About GeneDecksing


    Export disorders for CCP110 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCP110 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with CCP110)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. (PubMed id 16760425)1, 2, 3 Tsang W.Y.... Dynlacht B.D. (2006)
    2. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. (PubMed id 12361598)1, 2, 3 Chen Z.... Dynlacht B.D. (2002)
    3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
    4. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. (PubMed id 23486064)1, 2 Li J.... Dynlacht B.D. (2013)
    5. Neurl4, a novel daughter centriole protein, prevents f ormation of ectopic microtubule organizing centres. (PubMed id 22441691)1, 2 Li J....Dynlacht B.D. (2012)
    6. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1, 2 Al-Hakim A.K....Pelletier L. (2012)
    7. Centriolar kinesin Kif24 interacts with CP110 to remo del microtubules and regulate ciliogenesis. (PubMed id 21620453)1, 2 Kobayashi T....Dynlacht B.D. (2011)
    8. SCF(Cyclin F) controls centrosome homeostasis and mit otic fidelity through CP110 degradation. (PubMed id 20596027)1, 2 D'Angiolella V....Pagano M. (2010)
    9. Cep76, a centrosomal protein that specifically restrains centriole reduplication. (PubMed id 19460342)1, 2 Tsang W.Y.... Dynlacht B.D. (2009)
    10. Cep97 and CP110 suppress a cilia assembly program. (PubMed id 17719545)1, 2 Spektor A.... Dynlacht B.D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9738 HGNC: 24342 AceView: CP110 Ensembl:ENSG00000103540 euGenes: HUgn9738
    ECgene: CCP110 H-InvDB: CCP110

    (According to HUGE)
    About This Section
    HUGE: KIAA0419

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCP110 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCP110 gene:
    Search GeneIP for patents involving CCP110

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCP110  
     OriGene qPCR primer pairs and template standards for CCP110   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CCP110  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCP110   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CCP110   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCP110   OriGene Custom Protein Services for CCP110  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCP110
     QIAGEN SeqTarget long-range PCR primers for resequencing CCP110
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCP110
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCP110
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCP110
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCP110
     GenScript Custom Purified and Recombinant Proteins Services for CCP110 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CCP110
     GenScript Custom Assay Services for CCP110 GenScript Custom Superior Antibodies Services for CCP110
     GenScript Custom overexpressing Cell Line Services for CCP110 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CCP110  (CP110)

     Search Regulatory tfbs for CCP110
     Search Chromatin IP Primers for CCP110
     RT2 qPCR Primer Assay in human, mouse, rat CCP110
     Search GNC Networks for CCP110
     SABiosciences Custom PCR Arrays for CCP110
     Search Tocris compounds for CCP110 (CP110)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CCP110
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCP110 antibodies
     Antibodies for CCP110
     See all of Abcam's Antibodies, Kits and Proteins for CCP110
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CCP110
     Antibodies for CCP110
     ELISAs for CCP110
     CLIAs for CCP110
     Search LifeMap BioReagents cell lines for CCP110
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCP110
     SwitchGear 3'UTR luciferase reporter plasmids for CCP110
     SwitchGear Promoter luciferase reporter plasmids for CCP110
     ThermoFisher Antibodies for CCP110
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCP110
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCP110
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCP110
    Customized:
     lentivirus for stable overexpression of CCP110
     lentivirus expression plasmids for stable overexpression of CCP110
     adenovirus for overexpression of CCP110
     LSBio Antibodies in human, mouse, rat for CCP110
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCP110 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4