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Aliases for CCNYL1 Gene

Aliases for CCNYL1 Gene

  • Cyclin Y-Like 1 2 3

External Ids for CCNYL1 Gene

Previous GeneCards Identifiers for CCNYL1 Gene

  • GC02P208285
  • GC02P208576
  • GC02P200418

Summaries for CCNYL1 Gene

GeneCards Summary for CCNYL1 Gene

CCNYL1 (Cyclin Y-Like 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNY.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNYL1 Gene

Genomics for CCNYL1 Gene

Regulatory Elements for CCNYL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNYL1 Gene

Chromosome:
2
Start:
207,711,540 bp from pter
End:
207,761,839 bp from pter
Size:
50,300 bases
Orientation:
Plus strand

Genomic View for CCNYL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNYL1 Gene

Proteins for CCNYL1 Gene

  • Protein details for CCNYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7R7-CCYL1_HUMAN
    Recommended name:
    Cyclin-Y-like protein 1
    Protein Accession:
    Q8N7R7
    Secondary Accessions:
    • Q6NX60

    Protein attributes for CCNYL1 Gene

    Size:
    359 amino acids
    Molecular mass:
    40705 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH67253.1; Type=Frameshift; Positions=47; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNYL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNYL1 Gene

Proteomics data for CCNYL1 Gene at MOPED

Post-translational modifications for CCNYL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNYL1 Gene

Antibody Products

No data available for DME Specific Peptides for CCNYL1 Gene

Domains & Families for CCNYL1 Gene

Gene Families for CCNYL1 Gene

Protein Domains for CCNYL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNYL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7R7

UniProtKB/Swiss-Prot:

CCYL1_HUMAN :
  • Contains 1 cyclin N-terminal domain.
  • Belongs to the cyclin family. Cyclin Y subfamily.
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin Y subfamily.
genes like me logo Genes that share domains with CCNYL1: view

Function for CCNYL1 Gene

Gene Ontology (GO) - Molecular Function for CCNYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNYL1: view
genes like me logo Genes that share phenotypes with CCNYL1: view

Animal Model Products

miRNA for CCNYL1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNYL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNYL1 Gene

Localization for CCNYL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNYL1 Gene COMPARTMENTS Subcellular localization image for CCNYL1 gene
Compartment Confidence
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCNYL1 Gene

Pathways & Interactions for CCNYL1 Gene

SuperPathways for CCNYL1 Gene

No Data Available

Interacting Proteins for CCNYL1 Gene

Gene Ontology (GO) - Biological Process for CCNYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with CCNYL1: view

No data available for Pathways by source and SIGNOR curated interactions for CCNYL1 Gene

Drugs & Compounds for CCNYL1 Gene

No Compound Related Data Available

Transcripts for CCNYL1 Gene

Unigene Clusters for CCNYL1 Gene

Cyclin Y-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNYL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNYL1 Gene

No ASD Table

Relevant External Links for CCNYL1 Gene

GeneLoc Exon Structure for
CCNYL1
ECgene alternative splicing isoforms for
CCNYL1

Expression for CCNYL1 Gene

mRNA expression in normal human tissues for CCNYL1 Gene

Protein differential expression in normal tissues from HIPED for CCNYL1 Gene

This gene is overexpressed in Breast (21.9), Heart (18.8), Peripheral blood mononuclear cells (15.2), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNYL1 Gene



SOURCE GeneReport for Unigene cluster for CCNYL1 Gene Hs.471234

genes like me logo Genes that share expression patterns with CCNYL1: view

Protein tissue co-expression partners for CCNYL1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCNYL1 Gene

Orthologs for CCNYL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNYL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNYL1 35
  • 94.81 (n)
  • 98.62 (a)
CCNYL1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNYL1 35
  • 95.73 (n)
  • 97.92 (a)
CCNYL1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnyl1 35
  • 94.46 (n)
  • 98.96 (a)
Ccnyl1 16
Ccnyl1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnyl1 35
  • 93.7 (n)
  • 99.21 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNYL1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNYL1 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNYL1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNYL1 35
  • 83.45 (n)
  • 91.26 (a)
CCNYL1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNYL1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnyl1 35
  • 80.39 (n)
  • 87.89 (a)
Str.135 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14028 35
zebrafish
(Danio rerio)
Actinopterygii ccnyl1 35
  • 74.63 (n)
  • 86.51 (a)
wufi41h04 35
ccnyl1 36
  • 65 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.775 35
fruit fly
(Drosophila melanogaster)
Insecta CycY 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyy-1 36
  • 39 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6853 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5028 36
  • 50 (a)
OneToMany
Species with no ortholog for CCNYL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNYL1 Gene

ENSEMBL:
Gene Tree for CCNYL1 (if available)
TreeFam:
Gene Tree for CCNYL1 (if available)

Paralogs for CCNYL1 Gene

Paralogs for CCNYL1 Gene

(6) SIMAP similar genes for CCNYL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCNYL1: view

Variants for CCNYL1 Gene

Sequence variations from dbSNP and Humsavar for CCNYL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs906850 -- 207,710,198(-) ttttt(G/T)ttttt upstream-variant-2KB
rs906851 -- 207,743,123(-) GAAGC(C/T)TTCTC intron-variant
rs1043068 -- 207,755,419(+) TTTGT(A/G)AAGGT utr-variant-3-prime
rs1810105 -- 207,710,199(-) TTTTT(G/T)GTTTT upstream-variant-2KB
rs2012984 -- 207,714,490(+) TTCAG(G/T)GGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNYL1 Gene

Variant ID Type Subtype PubMed ID
nsv875742 CNV Gain 21882294
nsv3133 CNV Insertion 18451855

Variation tolerance for CCNYL1 Gene

Residual Variation Intolerance Score: 43.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNYL1 Gene

HapMap Linkage Disequilibrium report
CCNYL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNYL1 Gene

Disorders for CCNYL1 Gene

Relevant External Links for CCNYL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNYL1
genes like me logo Genes that share disorders with CCNYL1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNYL1 Gene

Publications for CCNYL1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67

Products for CCNYL1 Gene

Sources for CCNYL1 Gene

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