CCNYL1 Gene
protein-coding GIFtS: 43
GCID: GC02P208576
|
|
cyclin Y-like 1
| |
Aliases
for CCNYL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cyclin Y-Like 11 2 | | FLJ404321 | | Cyclin-Y-Like Protein 12 |
Export aliases for CCNYL1 gene to outside databasesPrevious GC identifers: GC02P208285 GC02P200418 |
Summaries
for CCNYL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCNYL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCNYL1 gene promoter:
E2F-4 E2F-3a USF1 E2F-5 E2F-2 Max E2F E2F-1 USF-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCNYL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNYL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.3 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q33.3CCNYL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P208576: view genomic region
(about GC identifiers)
Start:
|
208,576,264 bp from pter |
End:
|
208,626,563 bp from pter |
Size:
|
50,300 bases |
Orientation:
|
plus strand |
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Proteins
for CCNYL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCYL1_HUMAN, Q8N7R7 (See
protein sequence)Recommended Name: Cyclin-Y-like protein 1 Size: 359 amino acids; 40705 Da
Sequence caution: Sequence=AAH67253.1; Type=Frameshift; Positions=47;
Secondary accessions: Q6NX60Alternative splicing: 3 isoforms: Q8N7R7-1 Q8N7R7-2 Q8N7R7-3 Explore the universe of human proteins at neXtProt for CCNYL1: NX_Q8N7R7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N7R7
CCNYL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001135772.1 NP_689736.1
ENSEMBL proteins: ENSP00000376045 ENSP00000399151 ENSP00000295414 ENSP00000342344 ENSP00000388992 ENSP00000396072
Human Recombinant Protein Products:
CCNYL1 Antibody Products:
Assay Products for CCNYL1: |
Protein
Domains /
Families
for CCNYL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCNYL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N7R7ProtoNet protein and cluster: Q8N7R7 UniProtKB/Swiss-Prot: CCYL1_HUMAN, Q8N7R7Similarity: Belongs to the cyclin family. Cyclin Y subfamilySimilarity: Contains 1 cyclin N-terminal domain |
Function
for CCNYL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNYL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNYL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for CCNYL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNYL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNYL1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019901 | protein kinase binding |
IEA | -- |
CCNYL1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CCNYL1:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ccnyl1):
CCNYL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CCNYL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCNYL1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CCNYL1 (ENSP000003423444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000079 | regulation of cyclin-dependent protein kinase activity |
IEA | -- |
CCNYL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCNYL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCNYL1
Search CenterWatch for drugs/clinical trials and news about CCNYL1 / CCYL1
|
Transcripts
for CCNYL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCNYL1 gene (2 alternative transcripts): NM_001142300.1 NM_152523.2 Unigene Cluster for CCNYL1: Cyclin Y-like 1 Hs.471234 [show with all ESTs]Unigene Representative Sequence: NM_0011423007 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392209 ENST00000420822 ENST00000295414(uc002vch.3 uc002vci.3)
ENST00000339882 ENST00000452312 ENST00000420321 ENST00000468768
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNYL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNYL1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CCNYL1 (NM_001142300) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCNYL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNYL1 |
Additional cDNA sequence: AK026922.1 AK095479.1 AK097751.1 BC047293.1 BC067253.1 6 DOTS entries: DT.455322 DT.99939397 DT.120929613 DT.102828432 DT.120929621 DT.411844 24/110 AceView cDNA sequences (see all 110): BX280895 AA629680 AW958216 BM699271 AI272986 AI050814 AA873367 AA382892 BU627624 AI627872 AK097751 BQ016415 BF594533 BC047293 BM669486 CK300719 CA420811 AA478380 AA551049 NM_152523 AA345130 AK026922 AA416803 N53903
GeneLoc Exon Structure
|
Expression
for CCNYL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCNYL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTATATTAA
About this image
See CCNYL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNYL1
SOURCE GeneReport for Unigene cluster: Hs.471234
SABiosciences Custom PCR Arrays for CCNYL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNYL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCNYL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNYL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNYL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNYL1 |
Orthologs
for CCNYL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCNYL1 gene from 6/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CCNYL11 |
cyclin Y-like 1 |
83.45(n)
91.26(a) |
|
424093 XM_421948.3 XP_421948.3 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
71(a) |
1 → many |
GL343343.1(160095-182588) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.140282 |
Xenopus laevis transcribed sequence with weak similarity more |
78.98(n) |
|
BU916058.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi41h042 |
Transcribed sequence with weak similarity to protein more |
76.45(n) |
|
57066801 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CycY6 |
Cyclin Y |
40(a) |
1 → many |
2L(11810092-11813780) |
worm
(Caenorhabditis elegans) |
Secernentea |
cyy-16 |
Uncharacterized cyclin-like protein ZK353.1 |
40(a) |
possible ortholog |
III(8405802-8409331) |
ENSEMBL Gene Tree for CCNYL1 (if available)
TreeFam Gene Tree for CCNYL1 (if available) |
Paralogs
for CCNYL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCNYL1 gene
- CCNY2 CCNYL22
6 SIMAP similar genes for CCNYL1 using alignment to 4 protein entries: CCYL1_HUMAN (see all proteins):CCNY CCNYL2 CCNYL3 AGAP4 CTGLF11P AGAP8
CCNYL1 for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for CCNYL1 (see all 6)
PGOHUM00000249021 PGOHUM00000262336 PGOHUM00000234608 PGOHUM00000245230 PGOHUM00000260709
|
Genomic Variants
for CCNYL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCNYL1 (208576264 - 208626563 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNYL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNYL1 |
|
Disorders
/ Diseases
for CCNYL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCNYL1 for disorders About GeneDecksing
2  diseases for CCNYL1: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma
Export disorders for CCNYL1 gene to outside databases
|
Publications
for CCNYL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCNYL1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with CCNYL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
|
External Searches for CCNYL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCNYL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCNYL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCNYL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCNYL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCNYL1 gene:
Search GeneIP for patents involving CCNYL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCNYL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNYL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNYL1 | | | OriGene Protein Over-expression Lysate for CCNYL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCNYL1 | | OriGene 3'-UTR Clone for CCNYL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNYL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNYL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCNYL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNYL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNYL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNYL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNYL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNYL1 |
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 | | | CCNYL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNYL1 |
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