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Aliases for CCNYL1 Gene

Aliases for CCNYL1 Gene

  • Cyclin Y Like 1 2 3 5
  • Cyclin Y-Like 1 2

External Ids for CCNYL1 Gene

Previous GeneCards Identifiers for CCNYL1 Gene

  • GC02P208285
  • GC02P208576
  • GC02P200418

Summaries for CCNYL1 Gene

GeneCards Summary for CCNYL1 Gene

CCNYL1 (Cyclin Y Like 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNY.

Additional gene information for CCNYL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNYL1 Gene

Genomics for CCNYL1 Gene

Regulatory Elements for CCNYL1 Gene

Enhancers for CCNYL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H207631 1.2 Ensembl ENCODE 19.1 -78.9 -78858 2 PKNOX1 ATF1 SIN3A FOS KAT8 NFIL3 MAFF SMARCA4 PBX2 NBN METTL21A CCNYL1 PPP1R14BP2 RNU6-664P ENSG00000200764 RPS29P9
GH02H207676 1 Ensembl ENCODE 16.5 -34.5 -34478 1 JUN BATF FOSL1 ZNF664 POLR2A EED STAT2 FOS CEBPB DPF2 CCNYL1 METTL21A FZD5 LINC01857 GC02M207681 RNU6-664P GC02M207673
GH02H207734 1.2 ENCODE dbSUPER 11.2 +23.5 23471 0 FOXA2 ATF1 MLX ARID4B ZNF143 REST PPARG KAT8 NFIL3 RCOR2 METTL21A CCNYL1 ENSG00000200764 RNU6-664P PPP1R14BP2 FZD5 PLEKHM3 ENSG00000272851
GH02H207681 1.3 Ensembl ENCODE 9.4 -28.2 -28179 3 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 ZNF121 SLC30A9 GLIS2 FOS CREB1 PIKFYVE PLEKHM3 CCNYL1 PPP1R14BP2 GC02P207688
GH02H207623 1.4 ENCODE dbSUPER 8 -85.9 -85857 4 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 ENSG00000224342 LOC100533727 LOC100288663 ENSG00000231653 ENSG00000231896 CRYGC CCNYL1 METTL21A LINC01857 GC02P207602
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNYL1 on UCSC Golden Path with GeneCards custom track

Promoters for CCNYL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000129493 460 2801 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143

Genomic Location for CCNYL1 Gene

Chromosome:
2
Start:
207,711,540 bp from pter
End:
207,761,839 bp from pter
Size:
50,300 bases
Orientation:
Plus strand

Genomic View for CCNYL1 Gene

Genes around CCNYL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNYL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNYL1 Gene

Proteins for CCNYL1 Gene

  • Protein details for CCNYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7R7-CCYL1_HUMAN
    Recommended name:
    Cyclin-Y-like protein 1
    Protein Accession:
    Q8N7R7
    Secondary Accessions:
    • Q6NX60

    Protein attributes for CCNYL1 Gene

    Size:
    359 amino acids
    Molecular mass:
    40705 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH67253.1; Type=Frameshift; Positions=47; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNYL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNYL1 Gene

Post-translational modifications for CCNYL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNYL1 Gene

Domains & Families for CCNYL1 Gene

Gene Families for CCNYL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNYL1 Gene

Suggested Antigen Peptide Sequences for CCNYL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7R7

UniProtKB/Swiss-Prot:

CCYL1_HUMAN :
  • Belongs to the cyclin family. Cyclin Y subfamily.
Family:
  • Belongs to the cyclin family. Cyclin Y subfamily.
genes like me logo Genes that share domains with CCNYL1: view

Function for CCNYL1 Gene

Phenotypes From GWAS Catalog for CCNYL1 Gene

Gene Ontology (GO) - Molecular Function for CCNYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22184064
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNYL1: view
genes like me logo Genes that share phenotypes with CCNYL1: view

Animal Models for CCNYL1 Gene

MGI Knock Outs for CCNYL1:

Animal Model Products

CRISPR Products

miRNA for CCNYL1 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCNYL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNYL1 Gene

Localization for CCNYL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNYL1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCNYL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNYL1 Gene

Pathways & Interactions for CCNYL1 Gene

SuperPathways for CCNYL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0007283 spermatogenesis IEA --
GO:0030317 flagellated sperm motility IEA --
GO:0045859 regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with CCNYL1: view

No data available for Pathways by source and SIGNOR curated interactions for CCNYL1 Gene

Drugs & Compounds for CCNYL1 Gene

No Compound Related Data Available

Transcripts for CCNYL1 Gene

Unigene Clusters for CCNYL1 Gene

Cyclin Y-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCNYL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCNYL1 Gene

No ASD Table

Relevant External Links for CCNYL1 Gene

GeneLoc Exon Structure for
CCNYL1
ECgene alternative splicing isoforms for
CCNYL1

Expression for CCNYL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNYL1 Gene

Protein differential expression in normal tissues from HIPED for CCNYL1 Gene

This gene is overexpressed in Breast (21.9), Heart (18.8), Peripheral blood mononuclear cells (15.2), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCNYL1 Gene



Protein tissue co-expression partners for CCNYL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNYL1 Gene:

CCNYL1

SOURCE GeneReport for Unigene cluster for CCNYL1 Gene:

Hs.471234

Evidence on tissue expression from TISSUES for CCNYL1 Gene

  • Liver(4.2)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with CCNYL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNYL1 Gene

Orthologs for CCNYL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNYL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNYL1 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNYL1 33 34
  • 95.73 (n)
cow
(Bos Taurus)
Mammalia CCNYL1 33 34
  • 94.81 (n)
mouse
(Mus musculus)
Mammalia Ccnyl1 33 16 34
  • 94.46 (n)
rat
(Rattus norvegicus)
Mammalia Ccnyl1 33
  • 93.7 (n)
oppossum
(Monodelphis domestica)
Mammalia CCNYL1 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNYL1 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNYL1 33 34
  • 83.45 (n)
lizard
(Anolis carolinensis)
Reptilia CCNYL1 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnyl1 33
  • 80.39 (n)
Str.135 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14028 33
zebrafish
(Danio rerio)
Actinopterygii ccnyl1 33 34
  • 74.63 (n)
wufi41h04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.775 33
fruit fly
(Drosophila melanogaster)
Insecta CycY 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyy-1 34
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5028 34
  • 50 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6853 33
Species where no ortholog for CCNYL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNYL1 Gene

ENSEMBL:
Gene Tree for CCNYL1 (if available)
TreeFam:
Gene Tree for CCNYL1 (if available)

Paralogs for CCNYL1 Gene

Paralogs for CCNYL1 Gene

(6) SIMAP similar genes for CCNYL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCNYL1: view

Variants for CCNYL1 Gene

Sequence variations from dbSNP and Humsavar for CCNYL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000154338 -- 207,724,064(+) TTATC(G/T)TGACA intron-variant
rs1000179612 -- 207,740,983(+) GGGCA(A/C)GGTGG intron-variant
rs1000196925 -- 207,710,564(+) TTTTT(C/G)TATTT upstream-variant-2KB
rs1000259394 -- 207,753,045(+) GAAAA(-/AAAT)AATAA intron-variant, upstream-variant-2KB
rs1000296213 -- 207,751,398(+) TTGAA(C/T)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNYL1 Gene

Variant ID Type Subtype PubMed ID
nsv3133 CNV insertion 18451855
nsv963769 CNV duplication 23825009

Variation tolerance for CCNYL1 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNYL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNYL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNYL1 Gene

Disorders for CCNYL1 Gene

Relevant External Links for CCNYL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNYL1

No disorders were found for CCNYL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNYL1 Gene

Publications for CCNYL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for CCNYL1 Gene

Sources for CCNYL1 Gene

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