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Aliases for CCNY Gene

Aliases for CCNY Gene

  • Cyclin Y 2 3 5
  • Cyclin Fold Protein 1 3 4
  • Cyclin Box Protein 1 3 4
  • Cyclin-X 3 4
  • C10orf9 3 4
  • Cyc-Y 3 4
  • CBCP1 3 4
  • CFP1 3 4
  • Chromosome 10 Open Reading Frame 9 2
  • Cyclin-Box Carrying Protein 1 3
  • Cyclin-Y 3
  • CCNX 3

External Ids for CCNY Gene

Previous HGNC Symbols for CCNY Gene

  • C10orf9

Previous GeneCards Identifiers for CCNY Gene

  • GC10P035576

Summaries for CCNY Gene

Entrez Gene Summary for CCNY Gene

  • Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]

GeneCards Summary for CCNY Gene

CCNY (Cyclin Y) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is MIR4775.

UniProtKB/Swiss-Prot for CCNY Gene

  • Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.

Gene Wiki entry for CCNY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNY Gene

Genomics for CCNY Gene

Regulatory Elements for CCNY Gene

Enhancers for CCNY Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CCNY on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNY Gene

Chromosome:
10
Start:
35,246,981 bp from pter
End:
35,572,670 bp from pter
Size:
325,690 bases
Orientation:
Plus strand

Genomic View for CCNY Gene

Genes around CCNY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNY Gene

Proteins for CCNY Gene

  • Protein details for CCNY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND76-CCNY_HUMAN
    Recommended name:
    Cyclin-Y
    Protein Accession:
    Q8ND76
    Secondary Accessions:
    • B7ZKX9
    • D3DRY9
    • Q2M3V4
    • Q2TU96
    • Q6NT86
    • Q7Z4U7
    • Q8TEX2
    • Q8TEX3
    • Q96M99
    • Q96P45

    Protein attributes for CCNY Gene

    Size:
    341 amino acids
    Molecular mass:
    39337 Da
    Quaternary structure:
    • Interacts with CDK14, CDK16 and LRP6.
    SequenceCaution:
    • Sequence=AAH69224.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNY Gene

Post-translational modifications for CCNY Gene

  • Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination.
  • Ubiquitinated; leading to its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNY Gene

Domains & Families for CCNY Gene

Gene Families for CCNY Gene

Protein Domains for CCNY Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNY Gene

Graphical View of Domain Structure for InterPro Entry

Q8ND76

UniProtKB/Swiss-Prot:

CCNY_HUMAN :
  • Contains 1 cyclin N-terminal domain.
  • Belongs to the cyclin family. Cyclin Y subfamily.
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin Y subfamily.
genes like me logo Genes that share domains with CCNY: view

Function for CCNY Gene

Molecular function for CCNY Gene

UniProtKB/Swiss-Prot Function:
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.

Gene Ontology (GO) - Molecular Function for CCNY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19524571
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IDA 19524571
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNY: view
genes like me logo Genes that share phenotypes with CCNY: view

Animal Models for CCNY Gene

MGI Knock Outs for CCNY:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNY Gene

Localization for CCNY Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNY Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.
Isoform 3: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNY Gene COMPARTMENTS Subcellular localization image for CCNY gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCNY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA 19524571
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane IDA 19524571
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CCNY: view

Pathways & Interactions for CCNY Gene

SuperPathways for CCNY Gene

No Data Available

Pathways by source for CCNY Gene

1 GeneTex pathway for CCNY Gene

SIGNOR curated interactions for CCNY Gene

Activates:

Gene Ontology (GO) - Biological Process for CCNY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 20059949
GO:0016055 Wnt signaling pathway IEA --
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA 19524571
GO:0051301 cell division IEA --
GO:0060828 regulation of canonical Wnt signaling pathway IDA 20059949
genes like me logo Genes that share ontologies with CCNY: view

Drugs & Compounds for CCNY Gene

No Compound Related Data Available

Transcripts for CCNY Gene

Unigene Clusters for CCNY Gene

Cyclin Y:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNY Gene

No ASD Table

Relevant External Links for CCNY Gene

GeneLoc Exon Structure for
CCNY
ECgene alternative splicing isoforms for
CCNY

Expression for CCNY Gene

mRNA expression in normal human tissues for CCNY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNY Gene

This gene is overexpressed in Breast (23.6) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCNY Gene



Protein tissue co-expression partners for CCNY Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNY Gene:

CCNY

SOURCE GeneReport for Unigene cluster for CCNY Gene:

Hs.14745

mRNA Expression by UniProt/SwissProt for CCNY Gene:

Q8ND76-CCNY_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CCNY: view

Primer Products

No data available for mRNA differential expression in normal tissues for CCNY Gene

Orthologs for CCNY Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNY Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNY 34
  • 93.73 (n)
  • 99.3 (a)
CCNY 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNY 34
  • 94.83 (n)
  • 99.31 (a)
CCNY 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccny 34
  • 91.5 (n)
  • 98.24 (a)
Ccny 16
Ccny 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNY 34
  • 99.77 (n)
  • 100 (a)
CCNY 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccny 34
  • 91.5 (n)
  • 97.95 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNY 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNY 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNY 34
  • 86.02 (n)
  • 95.6 (a)
CCNY 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNY 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccny 34
  • 82.11 (n)
  • 92.67 (a)
zebrafish
(Danio rerio)
Actinopterygii ccny 34
  • 79.96 (n)
  • 91.2 (a)
ccny 35
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008969 34
  • 63.45 (n)
  • 68.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycY 34
  • 64.87 (n)
  • 70.71 (a)
CycY 35
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyy-1 34
  • 58.46 (n)
  • 58.36 (a)
cyy-1 35
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5028 35
  • 61 (a)
OneToMany
Species where no ortholog for CCNY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNY Gene

ENSEMBL:
Gene Tree for CCNY (if available)
TreeFam:
Gene Tree for CCNY (if available)

Paralogs for CCNY Gene

Paralogs for CCNY Gene

(5) SIMAP similar genes for CCNY Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCNY Gene

genes like me logo Genes that share paralogs with CCNY: view

Variants for CCNY Gene

Sequence variations from dbSNP and Humsavar for CCNY Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1998061 -- 35,348,764(+) GAATG(G/T)TTCGG intron-variant
rs2024933 -- 35,562,155(-) TTTAC(G/T)GGAAC intron-variant
rs2086153 -- 35,271,661(-) AGATG(A/G)TGGAG intron-variant
rs3214429 -- 35,472,997(-) TTTTT(-/C)CTAGC intron-variant
rs3215622 -- 35,337,733(+) TACCG(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNY Gene

Variant ID Type Subtype PubMed ID
dgv110e214 CNV gain 21293372
dgv129e199 CNV deletion 23128226
dgv396n106 CNV deletion 24896259
dgv397n106 CNV deletion 24896259
dgv707n100 CNV gain 25217958
esv1068454 CNV deletion 17803354
esv2004683 CNV deletion 18987734
esv2661770 CNV deletion 23128226
esv2735373 CNV deletion 23290073
esv2735384 CNV deletion 23290073
esv2735395 CNV deletion 23290073
esv2735406 CNV deletion 23290073
esv2735417 CNV deletion 23290073
esv3263273 CNV deletion 24192839
esv3384924 CNV duplication 20981092
esv3546154 CNV deletion 23714750
esv3546157 CNV deletion 23714750
esv3576383 CNV gain 25503493
esv3622897 CNV loss 21293372
esv3622898 CNV loss 21293372
esv3622899 CNV loss 21293372
esv3622901 CNV loss 21293372
esv5330 CNV loss 18987735
nsv1068685 CNV deletion 25765185
nsv1119793 CNV deletion 24896259
nsv1139519 CNV duplication 24896259
nsv1145439 CNV deletion 24896259
nsv479818 CNV novel sequence insertion 20440878
nsv481013 CNV novel sequence insertion 20440878
nsv550398 CNV gain 21841781
nsv550403 CNV gain 21841781
nsv6332 CNV deletion 18451855
nsv6343 CNV insertion 18451855
nsv958308 CNV deletion 24416366

Variation tolerance for CCNY Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNY Gene

Disorders for CCNY Gene

Relevant External Links for CCNY

Genetic Association Database (GAD)
CCNY
Human Genome Epidemiology (HuGE) Navigator
CCNY
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNY

No disorders were found for CCNY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNY Gene

Publications for CCNY Gene

  1. Lentivirus-mediated knockdown of cyclin Y (CCNY) inhibits glioma cell proliferation. (PMID: 20441050) Xu Y. … Yue W. (Oncol. Res. 2010) 2 3 22 65
  2. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PMID: 19174780) Weersma R.K. … Vermeire S. (Am. J. Gastroenterol. 2009) 3 22 46 65
  3. Cell cycle control of wnt receptor activation. (PMID: 20059949) Davidson G. … Niehrs C. (Dev. Cell 2009) 3 4 22 65
  4. Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. (PMID: 24794231) Li S. … Chen J. (FEBS Lett. 2014) 3 4 65
  5. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. (PMID: 22184064) Mikolcevic P. … Geley S. (Mol. Cell. Biol. 2012) 3 4 65

Products for CCNY Gene

Sources for CCNY Gene

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