Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CCNY Gene

protein-coding   GIFtS: 55
GCID: GC10P035576

Cyclin Y

(Previous name: chromosome 10 open reading frame 9)
(Previous symbol: C10orf9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cyclin Y1 2     CCNX2 5
C10orf91 2 3 5     Chromosome 10 Open Reading Frame 91
CFP12 3 5     cyc-Y2
Cyclin Box Protein 12 3     cyclin-Y2
Cyclin Fold Protein 12 3     Cyclin-Box Carrying Protein 12
CBCP12 3     Cyc-Y3
cyclin-X2 3     

External Ids:    HGNC: 233541   Entrez Gene: 2197712   Ensembl: ENSG000001081007   OMIM: 6127865   UniProtKB: Q8ND763   

Export aliases for CCNY gene to outside databases

Previous GC identifer: GC10P035254


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CCNY Gene:
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940)
(Li et al., 2009 (PubMed 18060517)).(supplied by OMIM, May 2009)

GeneCards Summary for CCNY Gene:
CCNY (cyclin Y) is a protein-coding gene. Diseases associated with CCNY include crohn's disease, and ulcerative colitis. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase binding. An important paralog of this gene is CCNYL1.

UniProtKB/Swiss-Prot: CCNY_HUMAN, Q8ND76
Function: Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle
regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and
promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the
plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription

Gene Wiki entry for CCNY Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNY gene promoter:
         Pax-5   GCNF   ATF-2   Pax-2   Nkx2-5   Pax-2a   Arnt   COMP1   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CCNY promoter sequence
   Search Chromatin IP Primers for CCNY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.21   Ensembl cytogenetic band:  10p11.21   HGNC cytogenetic band: 10p11.22

CCNY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNY gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P035576:  view genomic region     (about GC identifiers)

Start:
35,535,953 bp from pter      End:
35,860,852 bp from pter
Size:
324,900 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CCNY_HUMAN, Q8ND76 (See protein sequence)
Recommended Name: Cyclin-Y  
Size: 341 amino acids; 39337 Da
Subunit: Interacts with CDK14, CDK16 and LRP6
Developmental stage: Enriched at G2/M
Sequence caution: Sequence=AAH69224.1; Type=Erroneous initiation;
Secondary accessions: B7ZKX9 D3DRY9 Q2M3V4 Q2TU96 Q6NT86 Q7Z4U7 Q8TEX2 Q8TEX3 Q96M99 Q96P45
Alternative splicing: 3 isoforms:  Q8ND76-1   Q8ND76-2   Q8ND76-3   

Explore the universe of human proteins at neXtProt for CCNY: NX_Q8ND76

Explore proteomics data for CCNY at MOPED

Post-translational modifications: 

  • Ubiquitinated; leading to its degradation1
  • Ubiquitination2 at Lys72
  • Modification sites at PhosphoSitePlus

  • See CCNY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001269781.1  NP_001269782.1  NP_001269783.1  NP_659449.3  NP_859049.2  

    ENSEMBL proteins: 
     ENSP00000473487   ENSP00000363838   ENSP00000473625   ENSP00000363836   ENSP00000344275  
     ENSP00000265375  

    CCNY Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCNY
    OriGene Protein Over-expression Lysate for CCNY
    OriGene MassSpec for CCNY
    OriGene Custom Protein Services for CCNY
    GenScript Custom Purified and Recombinant Proteins Services for CCNY
    Novus Biologicals CCNY Protein
    Novus Biologicals CCNY Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNY

    CCNY Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCNY
    Novus Biologicals CCNY Antibodies
    Abcam antibodies for CCNY
    Cloud-Clone Corp. Antibodies for CCNY
    ThermoFisher Antibodies for CCNY
    LSBio Antibodies in human, mouse, rat for CCNY

    CCNY Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCNY
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCNY
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCNY
    Cloud-Clone Corp. CLIAs for CCNY


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR012399 Cyclin_Y
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N

    Graphical View of Domain Structure for InterPro Entry Q8ND76

    ProtoNet protein and cluster: Q8ND76

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNY_HUMAN, Q8ND76
    Similarity: Belongs to the cyclin family. Cyclin Y subfamily
    Similarity: Contains 1 cyclin N-terminal domain


    CCNY for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNY_HUMAN, Q8ND76
    Function: Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle
    regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and
    promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the
    plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19524571
    GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity IDA19524571
    GO:0019901protein kinase binding IEA--
         
    CCNY for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCNY:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNY
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCNY

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNY
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNY

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCNY:
    hsa-mir-215-5p (MIRT024653), hsa-mir-93-3p (MIRT038847), hsa-mir-193b-3p (MIRT041426), hsa-mir-744-5p (MIRT037619), hsa-let-7b-5p (MIRT032307), hsa-mir-192-5p (MIRT026358)

    Block miRNA regulation of human, mouse, rat CCNY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNY (see all 91):
    hsa-miR-548j hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-218-1* hsa-miR-128 hsa-miR-30d hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCNY 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCNY
    Predesigned siRNA for gene silencing in human, mouse, rat CCNY

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCNY

    Clone
    Products:
         
    OriGene clones in human, mouse for CCNY (see all 13)
    OriGene ORF clones in mouse, rat for CCNY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCNY (NM_001142300)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNY

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCNY
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCNY 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CCNY_HUMAN, Q8ND76: Cell membrane; Lipid-anchor; Cytoplasmic side
    CCNY_HUMAN, Q8ND76: Isoform 3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000308cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA19524571
    GO:0005634nucleus IDA--
    GO:0005886plasma membrane IDA19524571

    CCNY for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCNY
    Interactions:

        Search GeneGlobe Interaction Network for CCNY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CCNY (Q8ND761, 2, 3 ENSP000003638364) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK14O949211, 2, 3, ENSP000002657414EBI-1049189,EBI-1043945 MINT-7147585 MINT-7147628 MINT-7147743 MINT-7147695 MINT-7147713 MINT-7147647 MINT-7147665 MINT-7147614 MINT-7147598 MINT-7147680 MINT-7147725 I2D: score=3 STRING: ENSP00000265741
    YWHAGP619812, 3, ENSP000003063304MINT-50885 MINT-50680 I2D: score=3 STRING: ENSP00000306330
    SMARCB1Q128243I2D: score=5 
    BTBD10Q9BSF83I2D: score=2 
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ----
    GO:0000086G2/M transition of mitotic cell cycle IDA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0045737positive regulation of cyclin-dependent protein kinase activity IDA19524571
    GO:0051301cell division IEA--

    CCNY for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNY



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CCNY gene (5 alternative transcripts): 
    NM_001282852.1  NM_001282853.1  NM_001282854.1  NM_145012.5  NM_181698.3  

    Unigene Cluster for CCNY:

    Cyclin Y
    Hs.14745  [show with all ESTs]
    Unigene Representative Sequence: NM_145012
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490012 ENST00000374706(uc001iyu.4 uc001iyv.4) ENST00000493157
    ENST00000374704(uc001iyw.4 uc001iyx.4 uc009xmb.3 uc010qet.2)
    ENST00000492478 ENST00000470025 ENST00000465416 ENST00000497692 ENST00000339497
    ENST00000265375
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCNY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNY (see all 91):
    hsa-miR-548j hsa-miR-361-5p hsa-miR-607 hsa-miR-300 hsa-miR-218-1* hsa-miR-128 hsa-miR-30d hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCNY 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCNY
    Predesigned siRNA for gene silencing in human, mouse, rat CCNY
    Clone
    Products:
         
    OriGene clones in human, mouse for CCNY (see all 13)
    OriGene ORF clones in mouse, rat for CCNY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCNY (NM_001142300)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNY
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNY
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCNY
      QuantiTect SYBR Green Assays in human, mouse, rat CCNY
      QuantiFast Probe-based Assays in human, mouse, rat CCNY

    Additional mRNA sequence: 

    AF429969.1 AF465728.1 AF465729.1 AK024813.1 AK057280.1 AK303283.1 AK314666.1 AL834355.1 
    AY504868.1 BC015778.1 BC050310.1 BC069224.1 BC094815.1 BC104773.1 BC104801.1 BC143450.1 
    BC143455.1 

    21 DOTS entries:

    DT.101984089  DT.455788  DT.121245698  DT.91757492  DT.100793600  DT.95254611  DT.97849546  DT.91757501 
    DT.97849545  DT.121245637  DT.95362149  DT.75173441  DT.100793597  DT.121245590  DT.121245667  DT.95254600 
    DT.95254613  DT.95284277  DT.102834586  DT.121245572  DT.439585 

    Selected AceView cDNA sequences (see all 423):

    AK024813 BM850247 AI383106 AA700917 AA476431 BM693183 D25619 BU675909 
    AA365202 BE503208 AA723573 AI473134 AA505574 BG779150 CD518460 CA419612 
    CA444266 BE326554 AI638777 AI302146 BE677639 BQ181264 BE467812 BU728592 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CCNY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCAGACTT
    CCNY Expression
    About this image


    CCNY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    CCNY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNY Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14745

    UniProtKB/Swiss-Prot: CCNY_HUMAN, Q8ND76
    Tissue specificity: Widely expressed

        Custom PCR Arrays for CCNY
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNY
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCNY
    QuantiTect SYBR Green Assays in human, mouse, rat CCNY
    QuantiFast Probe-based Assays in human, mouse, rat CCNY
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CCNY gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccny1 , 5 cyclin Y1, 5 91.5(n)1
    98.24(a)1
      18 (4.91 cM)5
    679741  NM_026484.31  NP_080760.21 
     93140445 
    chicken
    (Gallus gallus)
    Aves CCNY1 cyclin Y 86.02(n)
    95.6(a)
      428412  XM_425973.3  XP_425973.2 
    lizard
    (Anolis carolinensis)
    Reptilia CCNY6
    cyclin Y
    90(a)
    1 ↔ 1
    6(10702877-10734131)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ccny1 cyclin Y 82.11(n)
    92.67(a)
      100492064  XM_002935160.2  XP_002935206.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccny1 cyclin Y 79.96(n)
    91.2(a)
      557738  XM_002666600.3  XP_002666646.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycY1 Cyclin Y 64.87(n)
    70.71(a)
      34593  NM_001273465.1  NP_001260394.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cyy-11 cyy-1 58.46(n)
    58.36(a)
      176188  NM_066457.3  NP_498858.2 


    ENSEMBL Gene Tree for CCNY (if available)
    TreeFam Gene Tree for CCNY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CCNY gene
    CCNYL12  
    5 SIMAP similar genes for CCNY using alignment to 3 protein entries:     CCNY_HUMAN (see all proteins):
    CCNYL1    CCNYL3    AGAP8    AGAP4    CCNYL2

    CCNY for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCNY
    PGOHUM00000236738


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CCNY (see all 5841)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1484549811,2
    C--35534241(+) AATTAC/TGTAAG 1 -- us2k10--------
    rs1901325831,2
    --35534330(+) GCTCAC/TGCCTG 1 -- us2k10--------
    rs1820605451,2
    --35534483(+) CCCAGC/TGACTT 1 -- us2k10--------
    rs1426319881,2
    --35534552(+) GATCGC/TGCCAC 1 -- us2k10--------
    rs1880585971,2
    --35534558(+) GCCACC/TGCACT 1 -- us2k10--------
    rs1145022891,2
    C,F--35534694(+) CTCTAT/CGATGC 1 -- us2k11Minor allele frequency- C:0.13WA 118
    rs1475851621,2
    --35534701(+) ATGCCC/TCATTA 1 -- us2k10--------
    rs1420299371,2
    --35534838(+) GCTTAC/TGGTTC 1 -- us2k10--------
    rs122553271,2
    C--35535311(+) GAGGCG/TGGTGG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs2006424241,2
    C--35535410(+) AGCAC-/AACGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNY (35535953 - 35785953 bp, first 250kb of CCNY)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CCNY (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735373CNV Deletion23290073
    esv2735417CNV Deletion23290073
    esv5330CNV Deletion18987735
    esv2735384CNV Deletion23290073
    esv1068454CNV Deletion17803354
    esv2004683CNV Deletion18987734
    esv2735395CNV Deletion23290073
    dgv129e199CNV Deletion23128226
    esv2661770CNV Deletion23128226
    esv2735406CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNY
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612786    OMIM disorders: --

    7 diseases for CCNY:    
    About MalaCards
    crohn's disease    ulcerative colitis    type 1 diabetes    inflammatory bowel disease
    alzheimer's disease    lung cancer    malaria


    CCNY for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCNY
    Human Genome Epidemiology (HuGE) Navigator: CCNY (10 documents)

    Export disorders for CCNY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CCNY gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with CCNY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lentivirus-mediated knockdown of cyclin Y (CCNY) inhibits glioma cell proliferation. (PubMed id 20441050)1, 3, 9 Xu Y....Yue W. (Oncol. Res. 2010)
    2. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1, 4, 9 Weersma R.K.... Vermeire S. (Am. J. Gastroenterol. 2009)
    3. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. (PubMed id 22184064)1, 2 Mikolcevic P.... Geley S. (Mol. Cell. Biol. 2012)
    4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    5. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)1, 4 Wang K....Hakonarson H. (Hum. Mol. Genet. 2010)
    6. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PubMed id 20886065)1, 4 Cleynen I....Vermeire S. (PLoS ONE 2010)
    7. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. (PubMed id 19068216)1, 4 Anderson C.A....Parkes M. (Gastroenterology 2009)
    8. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    9. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. (PubMed id 19524571)1, 2 Jiang M.... Chen J. (FEBS Lett. 2009)
    10. Genetic risk profiling and prediction of disease course in Crohn's disease patients. (PubMed id 19422935)1, 4 Henckaerts L....Vermeire S. (Clin. Gastroenterol. Hepatol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 219771 HGNC: 23354 AceView: C10orf9 Ensembl:ENSG00000108100 euGenes: HUgn219771
    ECgene: CCNY H-InvDB: CCNY

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CCNY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CCNY gene:
    Search GeneIP for patents involving CCNY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCNY  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CCNY  
     OriGene MassSpec something-or-other for CCNY   OriGene clones in human, mouse for CCNY  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCNY   OriGene Purified Protein for CCNY  
     OriGene ORF clones in mouse, rat for CCNY   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCNY   OriGene Custom Protein Services for CCNY  

     
     
     Block miRNA regulation of human, mouse, rat CCNY using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCNY
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNY Predesigned siRNA for gene silencing in human, mouse, rat CCNY
     QuantiFast Probe-based Assays in human, mouse, rat CCNY QuantiTect SYBR Green Assays in human, mouse, rat CCNY
     Custom PCR Arrays for CCNY Search Chromatin IP Primers for CCNY
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCNY  Search GeneGlobe Interaction Network for CCNY
     Regulatory tfbs in CCNY promoter
     GenScript Custom Purified and Recombinant Proteins Services for CCNY GenScript cDNA clones with any tag delivered in your preferred vector for CCNY
     GenScript Custom Assay Services for CCNY GenScript Custom overexpressing Cell Line Services for CCNY
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CCNY
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CCNY antibodies
     CCNY proteins
     CCNY lysates
     Antibodies for CCNY
     See all of Abcam's Antibodies, Kits and Proteins for CCNY
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CCNY
     Antibodies for CCNY
     ELISAs for CCNY
     CLIAs for CCNY



     Browse ESI BIO Cell Lines and PureStem Progenitors for CCNY
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNY
     SwitchGear 3'UTR luciferase reporter plasmids for CCNY
     SwitchGear Promoter luciferase reporter plasmids for CCNY
     ThermoFisher Antibodies for CCNY
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNY
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNY
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCNY
     LSBio Antibodies in human, mouse, rat for CCNY
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCNY gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4