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Aliases for CCNY Gene

Aliases for CCNY Gene

  • Cyclin Y 2 3
  • C10orf9 3 4 6
  • CFP1 3 4 6
  • Cyclin Fold Protein 1 3 4
  • Cyclin Box Protein 1 3 4
  • Cyclin-X 3 4
  • Cyc-Y 3 4
  • CBCP1 3 4
  • CCNX 3 6
  • Chromosome 10 Open Reading Frame 9 2
  • Cyclin-Box Carrying Protein 1 3
  • Cyclin-Y 3

External Ids for CCNY Gene

Previous Symbols for CCNY Gene

  • C10orf9

Summaries for CCNY Gene

Entrez Gene Summary for CCNY Gene

  • Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]

GeneCards Summary for CCNY Gene

CCNY (Cyclin Y) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CCNYL1.

UniProtKB/Swiss-Prot for CCNY Gene

  • Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.

Gene Wiki entry for CCNY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNY Gene

Genomics for CCNY Gene

Genomic Location for CCNY Gene

Start:
35,246,981 bp from pter
End:
35,572,670 bp from pter
Size:
325,690 bases
Orientation:
Plus strand

Genomic View for CCNY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNY Gene

Regulatory Elements for CCNY Gene

Proteins for CCNY Gene

  • Protein details for CCNY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND76-CCNY_HUMAN
    Recommended name:
    Cyclin-Y
    Protein Accession:
    Q8ND76
    Secondary Accessions:
    • B7ZKX9
    • D3DRY9
    • Q2M3V4
    • Q2TU96
    • Q6NT86
    • Q7Z4U7
    • Q8TEX2
    • Q8TEX3
    • Q96M99
    • Q96P45

    Protein attributes for CCNY Gene

    Size:
    341 amino acids
    Molecular mass:
    39337 Da
    Quaternary structure:
    • Interacts with CDK14, CDK16 and LRP6.
    SequenceCaution:
    • Sequence=AAH69224.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNY Gene

Proteomics data for CCNY Gene at MOPED

Post-translational modifications for CCNY Gene

  • Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination.
  • Ubiquitinated; leading to its degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys72

No data available for DME Specific Peptides for CCNY Gene

Domains for CCNY Gene

Protein Domains for CCNY Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CCNY_HUMAN
Domain:
  • Contains 1 cyclin N-terminal domain.:
    • Q8ND76
Family:
  • Belongs to the cyclin family. Cyclin Y subfamily.:
    • Q8ND76
genes like me logo Genes that share domains with CCNY: view

No data available for Gene Families for CCNY Gene

Function for CCNY Gene

Molecular function for CCNY Gene

UniProtKB/Swiss-Prot Function: Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.

Gene Ontology (GO) - Molecular Function for CCNY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19524571
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IDA 19524571
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNY: view

Phenotypes for CCNY Gene

GenomeRNAi human phenotypes for CCNY:
genes like me logo Genes that share phenotypes with CCNY: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCNY Gene

Localization for CCNY Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNY Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.
Isoform 3: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNY Gene COMPARTMENTS Subcellular localization image for CCNY gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCNY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA 19524571
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane IDA 19524571
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CCNY: view

Pathways for CCNY Gene

SuperPathways for CCNY Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0000086 G2/M transition of mitotic cell cycle IDA 20059949
GO:0016055 Wnt signaling pathway IEA --
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA 19524571
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CCNY: view

No data available for Pathways by source for CCNY Gene

Transcripts for CCNY Gene

Unigene Clusters for CCNY Gene

Cyclin Y:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNY Gene

No ASD Table

Relevant External Links for CCNY Gene

GeneLoc Exon Structure for
CCNY
ECgene alternative splicing isoforms for
CCNY

Expression for CCNY Gene

mRNA expression in normal human tissues for CCNY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNY Gene

SOURCE GeneReport for Unigene cluster for CCNY Gene Hs.14745

mRNA Expression by UniProt/SwissProt for CCNY Gene

Q8ND76-CCNY_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with CCNY: view

Orthologs for CCNY Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNY 36
  • 99.77 (n)
  • 100 (a)
CCNY 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNY 36
  • 93.73 (n)
  • 99.3 (a)
CCNY 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNY 36
  • 94.83 (n)
  • 99.31 (a)
CCNY 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccny 36
  • 91.5 (n)
  • 98.24 (a)
Ccny 16
Ccny 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNY 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNY 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccny 36
  • 91.5 (n)
  • 97.95 (a)
chicken
(Gallus gallus)
Aves CCNY 36
  • 86.02 (n)
  • 95.6 (a)
CCNY 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNY 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccny 36
  • 82.11 (n)
  • 92.67 (a)
zebrafish
(Danio rerio)
Actinopterygii ccny 36
  • 79.96 (n)
  • 91.2 (a)
ccny 37
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008969 36
  • 63.45 (n)
  • 68.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycY 36
  • 64.87 (n)
  • 70.71 (a)
CycY 37
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyy-1 36
  • 58.46 (n)
  • 58.36 (a)
cyy-1 37
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5028 37
  • 61 (a)
OneToMany
Species with no ortholog for CCNY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNY Gene

ENSEMBL:
Gene Tree for CCNY (if available)
TreeFam:
Gene Tree for CCNY (if available)

Paralogs for CCNY Gene

Paralogs for CCNY Gene

Selected SIMAP similar genes for CCNY Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCNY Gene

genes like me logo Genes that share paralogs with CCNY: view

Variants for CCNY Gene

Sequence variations from dbSNP and Humsavar for CCNY Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs731544 -- 35,368,475(+) ATGTT(A/G)TTATT intron-variant
rs875970 -- 35,382,689(-) TGTCT(C/G)AAGCT intron-variant
rs879110 -- 35,359,578(+) TGAAG(C/T)GATCT intron-variant
rs910963 -- 35,528,470(-) TGCCT(C/T)GGCCT intron-variant
rs910964 -- 35,528,425(-) CGCTC(A/G)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNY Gene

Variant ID Type Subtype PubMed ID
nsv6332 CNV Loss 18451855
esv2004683 CNV Deletion 18987734
esv5330 CNV Deletion 18987735
esv2735373 CNV Deletion 23290073
dgv129e199 CNV Deletion 23128226
esv2661770 CNV Deletion 23128226
esv2735384 CNV Deletion 23290073
esv2735395 CNV Deletion 23290073
esv2735406 CNV Deletion 23290073
esv1068454 CNV Deletion 17803354
esv2735417 CNV Deletion 23290073
nsv6343 CNV Insertion 18451855

Relevant External Links for CCNY Gene

HapMap Linkage Disequilibrium report
CCNY

Disorders for CCNY Gene

Relevant External Links for CCNY

Genetic Association Database (GAD)
CCNY
Human Genome Epidemiology (HuGE) Navigator
CCNY
genes like me logo Genes that share disorders with CCNY: view

No data available for UniProtKB/Swiss-Prot for CCNY Gene

Publications for CCNY Gene

  1. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PMID: 19174780) Weersma R.K. … Vermeire S. (Am. J. Gastroenterol. 2009) 3 23 49
  2. Cell cycle control of wnt receptor activation. (PMID: 20059949) Davidson G. … Niehrs C. (Dev. Cell 2009) 3 4 23
  3. Lentivirus-mediated knockdown of cyclin Y (CCNY) inhibits glioma cell proliferation. (PMID: 20441050) Xu Y. … Yue W. (Oncol. Res. 2010) 2 3 23
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for CCNY Gene

Sources for CCNY Gene

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