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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNT2 Gene

protein-coding   GIFtS: 60
GCID: GC02P135698

Cyclin T2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cyclin T21 2     cyclin-T22
CYCT22     SDS-Stable Vimentin-Bound DNA Fragment HEF42VIM222
Cyclin T2a2     Subunit Of Positive Elongation Transcription Factor B2
Cyclin T2b2     CycT23

External Ids:    HGNC: 16001   Entrez Gene: 9052   Ensembl: ENSG000000822587   OMIM: 6038625   UniProtKB: O605833   
ORGUL members:         
NONCODE14:n410507      

Export aliases for CCNT2 gene to outside databases

Previous GC identifers: GC02P133321 GC02P133964 GC02P135887 GC02P135509 GC02P135392 GC02P127668


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNT2 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the
transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with,
and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this
gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.(provided by RefSeq,
Dec 2010)

GeneCards Summary for CCNT2 Gene: 
CCNT2 (cyclin T2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CCNT2 include rhabdomyosarcoma, and adenocarcinoma, and among its related super-pathways are RNA Polymerase II Transcription Elongation and HIV Life Cycle. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNL2.

UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583
Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive
transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to
production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase
II (RNAP II)

Gene Wiki entry for CCNT2 (Cyclin T2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNT2 gene promoter:
         AML1a   Sp1   FOXF2   NRSF form 1   E47   POU2F1   POU2F1a   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CCNT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3

CCNT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNT2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P135698:  view genomic region     (about GC identifiers)

Start:
135,675,805 bp from pter      End:
135,716,915 bp from pter
Size:
41,111 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583 (See protein sequence)
Recommended Name: Cyclin-T2  
Size: 730 amino acids; 81029 Da
Subunit: Associates with CDK9 to form P-TEFb. Isoform 1 and isoform 2 interact with HIV-2 and SIV Tat. Does not
bind efficiently to the transactivation domain of the HIV-1 Tat
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for CCNT2:
2IVX (3D)    
Secondary accessions: A8KA48 D3DP73 D3DP74 O60582 Q29R66 Q53SR4 Q5I1Y0
Alternative splicing: 2 isoforms:  O60583-1   O60583-2   

Explore the universe of human proteins at neXtProt for CCNT2: NX_O60583

Explore proteomics data for CCNT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60583

  • CCNT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNT2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001232.1  NP_490595.1  

    ENSEMBL proteins: 
     ENSP00000404653   ENSP00000399497   ENSP00000400298   ENSP00000295238   ENSP00000264157  
     ENSP00000402512   ENSP00000387436   ENSP00000415120   ENSP00000439506  
    Reactome Protein details: O60583
    Human Recombinant Protein Products for CCNT2: 
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    Novus Biologicals CCNT2 Protein
    Novus Biologicals CCNT2 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNT2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16109376
    GO:0005654nucleoplasm TAS--

    CCNT2 for ontologies           About GeneDecksing



    CCNT2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for CCNT2 
    Cloud-Clone Corp. CLIAs for CCNT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR015429 Cyclin_C/H/T/L

    Graphical View of Domain Structure for InterPro Entry O60583

    ProtoNet protein and cluster: O60583

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    CCNT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNT2_HUMAN, O60583
    Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive
    transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to
    production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase
    II (RNAP II)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IEA--
         
    CCNT2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCNT2:
     Increased HPV18 LCR reporter a  Increased cell death in breast 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ccnt2):
     mortality/aging 

    CCNT2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNT2 

    miRNA
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    miRTarBase miRNAs that target CCNT2:
    hsa-mir-16 (MIRT001801)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNT2
    8/224 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNT2 (see all 224):
    hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-106a hsa-miR-938 hsa-miR-128 hsa-miR-1245 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCCNT2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCNT2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Formation of RNA Pol II elongation complex
    Formation of HIV elongation complex in the absence of HIV Tat0.76
    HIV elongation arrest and recovery0.74
    RNA Polymerase II Transcription Elongation0.76
    Pausing and recovery of HIV elongation0.74
    Formation of RNA Pol II elongation complex 0.76
    RNA Polymerase II Pre-transcription Events0.72
    Elongation arrest and recovery0.74
    Transcription of the HIV genome0.70
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    3Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Signaling by TGF-beta Receptor Complex0.61
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    Breast Cancer Regulation by Stathmin10.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNT2
        Breast Cancer Regulation by Stathmin1
    Pancreatic Adenocarcinoma

    5/20        Reactome Pathways for CCNT2 (see all 20)
        Formation of RNA Pol II elongation complex
    Late Phase of HIV Life Cycle
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    RNA Polymerase II Transcription
    Disease


    1         Kegg Pathway  (Kegg details for CCNT2):
        Transcriptional misregulation in cancer


    CCNT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for CCNT2 (O605833 ENSP000002641574) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD4O608853, ENSP000002633774I2D: score=2 STRING: ENSP00000263377
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    MLLT3P425683, ENSP000003696954I2D: score=1 STRING: ENSP00000369695
    CDK9P507503, ENSP000003623614I2D: score=5 STRING: ENSP00000362361
    PKN1Q165123, ENSP000003433254I2D: score=2 STRING: ENSP00000343325
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    CCNT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNT2

    Search CenterWatch for drugs/clinical trials and news about CCNT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNT2 gene (2 alternative transcripts): 
    NM_001241.3  NM_058241.2  

    Unigene Cluster for CCNT2:

    Cyclin T2
    Hs.744115  [show with all ESTs]
    Unigene Representative Sequence: NM_058241
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419781 ENST00000446247 ENST00000452839 ENST00000295238 ENST00000264157(uc010zbf.2 uc002tub.2 uc002tuc.2 uc002tud.2)
    ENST00000475094 ENST00000464932 ENST00000417175 ENST00000452521 ENST00000438691
    ENST00000537343
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/224 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNT2 (see all 224):
    hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-106a hsa-miR-938 hsa-miR-128 hsa-miR-1245 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCCNT2 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNT2
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    Additional mRNA sequence: 

    AF048731.1 AF048732.1 AK023645.1 AK075041.1 AK292913.1 AK294889.1 BC114366.2 BX648174.1 
    NR_037649.1 

    13 DOTS entries:

    DT.114190  DT.75127817  DT.100672775  DT.95248449  DT.95200382  DT.92423498  DT.121642210  DT.120938115 
    DT.75141944  DT.100783657  DT.114191  DT.86837919  DT.91640590 

    24/184 AceView cDNA sequences (see all 184):

    BG943619 AI559232 AA747539 CA390157 BU733840 BM974814 AW152646 AI061460 
    AI004990 CB128783 AW512545 CA946761 AI334118 AA831390 AI457106 BE644772 
    BX474808 AI806736 AA737512 BM724747 AW182918 BM709798 AA723794 BX489822 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CCNT2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ·
    SP1:                                                              -     -                 -                             -                                       
    SP2:                                                              -     -     -     -     -           -     -     -     -                                       
    SP3:                                                              -     -     -     -     -           -     -     -     -                                       
    SP4:                                                              -     -                 -           -     -     -     -                                       
    SP5:                                                              -                                                                                             

    ExUns: 11c ^ 12a · 12b · 12c · 12d
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CCNT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNT2 expression in normal human tissues (normalized intensities)      CCNT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCNT2 Expression
    About this image


    CCNT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
             breast epithelium   
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             posterior singulate   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow cd34+   
     
     Breast
             breast ; myoepithelial cells   
             breast epithelium   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See CCNT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNT2

    SOURCE GeneReport for Unigene cluster: Hs.744115

    UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCNT2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnt21 , 5 cyclin T21, 5 88.01(n)1
    88.33(a)1
      1 (55.80 cM)5
    729491  NM_028399.11  NP_082675.11 
     1277741645 
    chicken
    (Gallus gallus)
    Aves CCNT21 cyclin T2 81.93(n)
    84.53(a)
      424289  XM_422134.3  XP_422134.3 
    lizard
    (Anolis carolinensis)
    Reptilia CCNT26
    cyclin T2
    79(a)
    1 ↔ 1
    1(96449074-96465347)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA791672.12   -- 85.24(n)    CA791672.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044378.12   -- 82.31(n)   327568  BC044378.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycT3 response to heat transcription
    elongation factor
    59(a)   74D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cit-1.16
    cit-1.26
    Cyclin-T1.2
    21(a)
    19(a)
    many ↔ many
    many ↔ many
    III(8005826-8009823)
    III(8010778-8013771)


    ENSEMBL Gene Tree for CCNT2 (if available)
    TreeFam Gene Tree for CCNT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNT2 gene
    CCNL22  CCNK2  CCNC2  CCNL12  FAM58A2  CCNT12  
    3 SIMAP similar genes for CCNT2 using alignment to 7 protein entries:     CCNT2_HUMAN (see all proteins):
    CYCT1b    CCNK    CCNT1

    CCNT2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCNT2
    PGOHUM00000244141


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/845 SNPs in CCNT2 are shown (see all 845)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924533491,2
    --127667761(+) TCCCCA/TCCCCG 3 -- us2k10--------
    rs38418621,2
    C--127669165(-) ACAACAAAC/-  
            
    TAGTA
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1881469741,2
    C--127677596(+) GGAGTC/GCAATG 3 -- int10--------
    rs746216111,2
    C--127677599(+) GTGCAA/GTGGCG 3 -- int10--------
    rs1995567771,2
    --127678389(+) AATGC-/CAAAAAG 3 -- int10--------
    rs2014679591,2
    C--127678918(+) ATGCC-/TTTTTT 3 -- int10--------
    rs105762981,2
    C--127681451(+) CACCA-/TGTGTTA 3 -- int10--------
    rs763546461,2
    --127695033(+) TCTTCC/TTTTTT 3 -- int11Minor allele frequency- T:0.50NA 2
    rs113859001,2
    C--127697985(+) TTTTT-/TGAGTC 3 -- int1 trp30--------
    rs603208051,2
    C--127699072(+) GGGGG-/CG/   
      TG
    /TGG
    GGGGG
    5 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for CCNT2 (135675805 - 135716915 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCNT2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNT2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603862    OMIM disorders: --

    5 diseases for CCNT2:    About MalaCards
    rhabdomyosarcoma    adenocarcinoma    pancreatitis    breast cancer
    leukemia


    CCNT2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CCNT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 32 1 10049833 (1)

    Genetic Association Database (GAD): CCNT2
    Human Genome Epidemiology (HuGE) Navigator: CCNT2 (1 document)

    Export disorders for CCNT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNT2 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with CCNT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of multiple cyclin subunits of human P-TEFb. (PubMed id 9499409)1, 2, 3, 9 Peng J.-M.... Price D.H. (1998)
    2. The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity. (PubMed id 10465067)1, 3, 9 Napolitano G....Lania L. (1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. (PubMed id 10364329)1, 2 Bieniasz P.D.... Cullen B.R. (1999)
    7. Pkn is a novel partner of cyclin T2a in muscle differentiation. (PubMed id 16331689)1, 9 Cottone G....De Luca A. (2006)
    8. Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. (PubMed id 10329126)1, 9 Kwak Y.T.... Gaynor R.B. (1999)
    9. Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. (PubMed id 10049833)1, 9 Wimmer J....Peterlin B.M. (1999)
    10. Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb. (PubMed id 15563843)1, 9 Kurosu T....Peterlin B.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 905 HGNC: 1600 AceView: CCNT2 Ensembl:ENSG00000082258 euGenes: HUgn905
    ECgene: CCNT2 Kegg: 905 H-InvDB: CCNT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNT2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnt2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNT2 gene:
    Search GeneIP for patents involving CCNT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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