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Aliases for CCNT2 Gene

Aliases for CCNT2 Gene

  • Cyclin T2 2 3
  • CYCT2 3 4
  • Subunit Of Positive Elongation Transcription Factor B 3
  • SDS-Stable Vimentin-Bound DNA Fragment HEF42VIM22 3
  • Cyclin T2a 3
  • Cyclin T2b 3
  • Cyclin-T2 3

External Ids for CCNT2 Gene

Summaries for CCNT2 Gene

Entrez Gene Summary for CCNT2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

GeneCards Summary for CCNT2 Gene

CCNT2 (Cyclin T2) is a Protein Coding gene. Diseases associated with CCNT2 include hiv-1. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNT1.

UniProtKB/Swiss-Prot for CCNT2 Gene

  • Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).

Gene Wiki entry for CCNT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNT2 Gene

Genomics for CCNT2 Gene

Genomic Location for CCNT2 Gene

Start:
134,918,235 bp from pter
End:
134,959,345 bp from pter
Size:
41,111 bases
Orientation:
Plus strand

Genomic View for CCNT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNT2 Gene

Regulatory Elements for CCNT2 Gene

Proteins for CCNT2 Gene

  • Protein details for CCNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60583-CCNT2_HUMAN
    Recommended name:
    Cyclin-T2
    Protein Accession:
    O60583
    Secondary Accessions:
    • A8KA48
    • D3DP73
    • D3DP74
    • O60582
    • Q29R66
    • Q53SR4
    • Q5I1Y0

    Protein attributes for CCNT2 Gene

    Size:
    730 amino acids
    Molecular mass:
    81029 Da
    Quaternary structure:
    • Associates with CDK9 to form P-TEFb. Isoform 1 and isoform 2 interact with HIV-2 and SIV Tat. Does not bind efficiently to the transactivation domain of the HIV-1 Tat

    Three dimensional structures from OCA and Proteopedia for CCNT2 Gene

    Alternative splice isoforms for CCNT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNT2 Gene

Proteomics data for CCNT2 Gene at MOPED

Post-translational modifications for CCNT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNT2 Gene

No data available for DME Specific Peptides for CCNT2 Gene

Domains for CCNT2 Gene

Protein Domains for CCNT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNT2 Gene

Graphical View of Domain Structure for InterPro Entry

O60583

UniProtKB/Swiss-Prot:

CCNT2_HUMAN
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.:
    • O60583
genes like me logo Genes that share domains with CCNT2: view

No data available for Gene Families for CCNT2 Gene

Function for CCNT2 Gene

Molecular function for CCNT2 Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).

Gene Ontology (GO) - Molecular Function for CCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNT2: view

Phenotypes for CCNT2 Gene

genes like me logo Genes that share phenotypes with CCNT2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCNT2 Gene

Localization for CCNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNT2 Gene COMPARTMENTS Subcellular localization image for CCNT2 gene
Compartment Confidence
nucleus 5
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CCNT2: view

Pathways for CCNT2 Gene

genes like me logo Genes that share pathways with CCNT2: view

Pathways by source for CCNT2 Gene

Gene Ontology (GO) - Biological Process for CCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0006351 transcription, DNA-templated TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with CCNT2: view

Transcripts for CCNT2 Gene

Unigene Clusters for CCNT2 Gene

Cyclin T2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ·
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - - -
SP7: - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - -
SP10:
SP11: -
SP12: -
SP13:

ExUns: 11c ^ 12a · 12b · 12c · 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for CCNT2 Gene

GeneLoc Exon Structure for
CCNT2
ECgene alternative splicing isoforms for
CCNT2

Expression for CCNT2 Gene

mRNA expression in normal human tissues for CCNT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNT2 Gene

SOURCE GeneReport for Unigene cluster for CCNT2 Gene Hs.744115

mRNA Expression by UniProt/SwissProt for CCNT2 Gene

O60583-CCNT2_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with CCNT2: view

No data available for mRNA differential expression in normal tissues for CCNT2 Gene

Orthologs for CCNT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNT2 35
  • 99.77 (n)
  • 99.86 (a)
CCNT2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNT2 35
  • 95.19 (n)
  • 94.78 (a)
CCNT2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNT2 35
  • 95.71 (n)
  • 96.71 (a)
CCNT2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnt2 35
  • 86.06 (n)
  • 86.25 (a)
Ccnt2 16
Ccnt2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNT2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNT2 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnt2 35
  • 85.3 (n)
  • 84.98 (a)
chicken
(Gallus gallus)
Aves CCNT2 35
  • 81.14 (n)
  • 83.13 (a)
CCNT2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNT2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnt2 35
  • 75.74 (n)
  • 76.53 (a)
Str.6760 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ccnt2a 35
  • 66.42 (n)
  • 67.21 (a)
ccnt2a 36
  • 62 (a)
OneToMany
ccnt2b 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CycT 36
  • 23 (a)
OneToMany
CycT 37
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea cit-1.1 36
  • 25 (a)
ManyToMany
cit-1.2 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToMany
Species with no ortholog for CCNT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNT2 Gene

ENSEMBL:
Gene Tree for CCNT2 (if available)
TreeFam:
Gene Tree for CCNT2 (if available)

Paralogs for CCNT2 Gene

Paralogs for CCNT2 Gene

Selected SIMAP similar genes for CCNT2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CCNT2 Gene

genes like me logo Genes that share paralogs with CCNT2: view

Variants for CCNT2 Gene

Sequence variations from dbSNP and Humsavar for CCNT2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1057045 -- 134,955,678(+) ATGAC(A/C)CCATA utr-variant-3-prime, nc-transcript-variant
rs1057046 -- 134,955,686(+) ATATT(C/T)TTAAA utr-variant-3-prime, nc-transcript-variant
rs1374289 -- 134,936,809(-) TTTAA(A/G)AACAA intron-variant
rs1823118 -- 134,936,784(-) ACCCT(C/G)TATTT intron-variant
rs1947112 -- 134,958,387(-) TACTG(C/T)CTCCC utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B

Relevant External Links for CCNT2 Gene

HapMap Linkage Disequilibrium report
CCNT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCNT2 Gene

Disorders for CCNT2 Gene

(1) MalaCards Diseases for CCNT2 Gene

Search for CCNT2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for CCNT2 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 32 1

Relevant External Links for CCNT2

Genetic Association Database (GAD)
CCNT2
Human Genome Epidemiology (HuGE) Navigator
CCNT2
genes like me logo Genes that share disorders with CCNT2: view

No data available for UniProtKB/Swiss-Prot for CCNT2 Gene

Publications for CCNT2 Gene

  1. Identification of multiple cyclin subunits of human P-TEFb. (PMID: 9499409) Peng J.-M. … Price D.H. (Genes Dev. 1998) 2 3 4 23
  2. The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity. (PMID: 10465067) Napolitano G. … Lania L. (AIDS 1999) 2 3 23
  3. Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. (PMID: 10049833) Wimmer J. … Peterlin B.M. (Virology 1999) 3 23
  4. Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. (PMID: 10329126) Kwak Y.T. … Gaynor R.B. (J. Mol. Biol. 1999) 3 23
  5. Pkn is a novel partner of cyclin T2a in muscle differentiation. (PMID: 16331689) Cottone G. … De Luca A. (J. Cell. Physiol. 2006) 3 23

Products for CCNT2 Gene

  • Addgene plasmids for CCNT2

Sources for CCNT2 Gene

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