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CCNT2 Gene

protein-coding   GIFtS: 55
GCID: GC02P135698

Cyclin T2

  See CCNT2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin T21 2     cyclin-T22
CYCT22     SDS-Stable Vimentin-Bound DNA Fragment HEF42VIM222
Cyclin T2a2     Subunit Of Positive Elongation Transcription Factor B2
Cyclin T2b2     CycT23

External Ids:    HGNC: 16001   Entrez Gene: 9052   Ensembl: ENSG000000822587   OMIM: 6038625   UniProtKB: O605833   

Export aliases for CCNT2 gene to outside databases

Previous GC identifers: GC02P133321 GC02P133964 GC02P135887 GC02P135509 GC02P135392 GC02P127668


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNT2 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the
transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with,
and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this
gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.(provided by RefSeq,
Dec 2010)

GeneCards Summary for CCNT2 Gene:
CCNT2 (cyclin T2) is a protein-coding gene. Diseases associated with CCNT2 include hiv-1. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNL2.

UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583
Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive
transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to
production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase
II (RNAP II)

Gene Wiki entry for CCNT2 (Cyclin T2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CCNT2 gene promoter:
         AML1a   Sp1   FOXF2   NRSF form 1   E47   POU2F1   POU2F1a   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CCNT2 promoter sequence
   Search Chromatin IP Primers for CCNT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3

CCNT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNT2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P135698:  view genomic region     (about GC identifiers)

Start:
135,675,805 bp from pter      End:
135,716,915 bp from pter
Size:
41,111 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583 (See protein sequence)
Recommended Name: Cyclin-T2  
Size: 730 amino acids; 81029 Da
Subunit: Associates with CDK9 to form P-TEFb. Isoform 1 and isoform 2 interact with HIV-2 and SIV Tat. Does not
bind efficiently to the transactivation domain of the HIV-1 Tat
1 PDB 3D structure from and Proteopedia for CCNT2:
2IVX (3D)    
Secondary accessions: A8KA48 D3DP73 D3DP74 O60582 Q29R66 Q53SR4 Q5I1Y0
Alternative splicing: 2 isoforms:  O60583-1   O60583-2   

Explore the universe of human proteins at neXtProt for CCNT2: NX_O60583

Explore proteomics data for CCNT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCNT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001232.1  NP_490595.1  

    ENSEMBL proteins: 
     ENSP00000404653   ENSP00000399497   ENSP00000400298   ENSP00000295238   ENSP00000264157  
     ENSP00000402512   ENSP00000387436   ENSP00000415120   ENSP00000439506  
    Reactome Protein details: O60583

    CCNT2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CCNT2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR015429 Cyclin_C/H/T/L
     IPR028862 CCNT2

    Graphical View of Domain Structure for InterPro Entry O60583

    ProtoNet protein and cluster: O60583

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    Find genes that share domains with CCNT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNT2_HUMAN, O60583
    Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive
    transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to
    production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase
    II (RNAP II)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IEA--
         
    Find genes that share ontologies with CCNT2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCNT2:
     Increased HPV18 LCR reporter a  Increased cell death in breast 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ccnt2):
     mortality/aging 

    Find genes that share phenotypes with CCNT2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNT2
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    miRNA
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    miRTarBase miRNAs that target CCNT2:
    hsa-mir-204-5p (MIRT047016), hsa-mir-196a-5p (MIRT026073), hsa-mir-423-3p (MIRT042585), hsa-mir-29c-3p (MIRT020397), hsa-mir-16-5p (MIRT001801), hsa-mir-877-5p (MIRT037376), hsa-mir-484 (MIRT041987), hsa-mir-22-3p (MIRT030643)

    Block miRNA regulation of human, mouse, rat CCNT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNT2 (see all 224):
    hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-106a hsa-miR-938 hsa-miR-128 hsa-miR-1245 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCCNT2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNT2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNT2
    Addgene plasmids for CCNT2 

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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNT2_HUMAN, O60583: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16109376
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with CCNT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNT2 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    2Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription Elongation0.75
    Pausing and recovery of HIV elongation0.73
    Formation of RNA Pol II elongation complex0.75
    HIV elongation arrest and recovery0.73
    Formation of HIV elongation complex in the absence of HIV Tat0.75
    Transcription of the HIV genome0.71
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II Transcription0.60
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    Breast Cancer Regulation by Stathmin10.58
    5Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with CCNT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNT2
        Breast Cancer Regulation by Stathmin1
    Pancreatic Adenocarcinoma

    Selected Reactome Pathways for CCNT2 (see all 7)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of HIV elongation
    RNA Polymerase II Transcription Elongation
    RNA Polymerase II Pre-transcription Events
    HIV elongation arrest and recovery


    1 Kegg Pathway  (Kegg details for CCNT2):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCNT2
    Interactions:

        GeneGlobe Interaction Network for CCNT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNT2 (O605833 ENSP000002641574) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD4O608853, ENSP000002633774I2D: score=2 STRING: ENSP00000263377
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    MLLT3P425683, ENSP000003696954I2D: score=1 STRING: ENSP00000369695
    CDK9P507503, ENSP000003623614I2D: score=5 STRING: ENSP00000362361
    PKN1Q165123, ENSP000003433254I2D: score=2 STRING: ENSP00000343325
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with CCNT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNT2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNT2 gene (2 alternative transcripts): 
    NM_001241.3  NM_058241.2  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419781 ENST00000446247 ENST00000452839 ENST00000295238 ENST00000264157(uc010zbf.2 uc002tub.2 uc002tuc.2 uc002tud.2)
    ENST00000475094 ENST00000464932 ENST00000417175 ENST00000452521 ENST00000438691
    ENST00000537343
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CCNT2 (see all 224):
    hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-106a hsa-miR-938 hsa-miR-128 hsa-miR-1245 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCCNT2 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for CCNT2 
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCNT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNT2
      QuantiTect SYBR Green Assays in human, mouse, rat CCNT2
      QuantiFast Probe-based Assays in human, mouse, rat CCNT2

    Selected AceView cDNA sequences (see all 184):

    BG943619 BM709798 BU733840 AI806736 AA330452 BQ025119 CA946761 AA732241 
    BX474808 AA767019 AA737512 AI559232 CB128783 AA485144 BM724747 CA393618 
    AA747539 AA723794 AA831390 AW182918 AI004990 AI457106 BX489822 BE644772 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCNT2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ·
    SP1:                                                              -     -                 -                             -                                       
    SP2:                                                              -     -     -     -     -           -     -     -     -                                       
    SP3:                                                              -     -     -     -     -           -     -     -     -                                       
    SP4:                                                              -     -                 -           -     -     -     -                                       
    SP5:                                                              -                                                                                             

    ExUns: 11c ^ 12a · 12b · 12c · 12d
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CCNT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCNT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCNT2 Expression
    About this image


    CCNT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CCNT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNT2 Protein Expression

    UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for CCNT2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for CCNT2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnt21 , 5 cyclin T21, 5 86.06(n)1
    86.25(a)1
      1 (55.80 cM)5
    729491  NM_028399.11  NP_082675.11 
     1277741645 
    chicken
    (Gallus gallus)
    Aves CCNT21 cyclin T2 81.14(n)
    83.13(a)
      424289  XM_004942989.1  XP_004943046.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNT26
    cyclin T2
    79(a)
    1 ↔ 1
    1(96449074-96465347)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA791672.12   -- 85.24(n)    CA791672.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044378.12   -- 82.31(n)   327568  BC044378.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycT3 response to heat transcription
    elongation factor
    59(a)   74D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cit-1.16
    cit-1.26
    Protein CIT-1.2, isoform a
    25(a)
    22(a)
    many ↔ many
    many ↔ many
    III(8005826-8009821) WBGene00000507
    III(8010778-8013771) WBGene00000508


    ENSEMBL Gene Tree for CCNT2 (if available)
    TreeFam Gene Tree for CCNT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNT2 gene
    CCNL22  CCNK2  CCNC2  CCNL12  FAM58A2  CCNT12  
    3 SIMAP similar genes for CCNT2 using alignment to 7 protein entries:     CCNT2_HUMAN (see all proteins):
    CYCT1b    CCNK    CCNT1

    Find genes that share paralogs with CCNT2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCNT2
    PGOHUM00000244141


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNT2 (see all 845)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924533491,2
    --127667761(+) TCCCCA/TCCCCG 3 -- us2k10--------
    rs38418621,2
    C--127669165(-) ACAACAAAC/-  
            
    TAGTA
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1881469741,2
    C--127677596(+) GGAGTC/GCAATG 3 -- int10--------
    rs746216111,2
    C--127677599(+) GTGCAA/GTGGCG 3 -- int10--------
    rs1995567771,2
    --127678389(+) AATGC-/CAAAAAG 3 -- int10--------
    rs2014679591,2
    C--127678918(+) ATGCC-/TTTTTT 3 -- int10--------
    rs105762981,2
    C--127681451(+) CACCA-/TGTGTTA 3 -- int10--------
    rs763546461,2
    --127695033(+) TCTTCC/TTTTTT 3 -- int11Minor allele frequency- T:0.50NA 2
    rs113859001,2
    C--127697985(+) TTTTT-/TGAGTC 3 -- int1 trp30--------
    rs603208051,2
    C--127699072(+) GGGGG-/CG/   
      TG
    /TGG
    GGGGG
    5 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for CCNT2 (135675805 - 135716915 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCNT2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNT2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603862    OMIM disorders: --

    1 disease for CCNT2:    
    About MalaCards
    hiv-1


    Find genes that share disorders with CCNT2           About GenesLikeMe

    1 Novoseek inferred disease relationship for CCNT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 32 1 10049833 (1)

    Genetic Association Database (GAD): CCNT2
    Human Genome Epidemiology (HuGE) Navigator: CCNT2 (1 document)

    Export disorders for CCNT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNT2 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with CCNT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of multiple cyclin subunits of human P-TEFb. (PubMed id 9499409)1, 2, 3, 9 Peng J.-M.... Price D.H. (Genes Dev. 1998)
    2. The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity. (PubMed id 10465067)1, 3, 9 Napolitano G....Lania L. (AIDS 1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. (PubMed id 10364329)1, 2 Bieniasz P.D.... Cullen B.R. (J. Virol. 1999)
    7. Pkn is a novel partner of cyclin T2a in muscle differentiation. (PubMed id 16331689)1, 9 Cottone G....De Luca A. (J. Cell. Physiol. 2006)
    8. Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. (PubMed id 10329126)1, 9 Kwak Y.T.... Gaynor R.B. (J. Mol. Biol. 1999)
    9. Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. (PubMed id 10049833)1, 9 Wimmer J....Peterlin B.M. (Virology 1999)
    10. Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb. (PubMed id 15563843)1, 9 Kurosu T....Peterlin B.M. (Gene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 905 HGNC: 1600 AceView: CCNT2 Ensembl:ENSG00000082258 euGenes: HUgn905
    ECgene: CCNT2 Kegg: 905 H-InvDB: CCNT2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNT2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnt2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNT2 gene:
    Search GeneIP for patents involving CCNT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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