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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCNT2 Gene

protein-coding GIFtS: 56
GCID: GC02P135698

cyclin T2

Explore 9 diseases affiliated with
CCNT2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cyclin T2¹ ²		Cyclin-T2¹
CYCT2²		SDS-Stable Vimentin-Bound DNA Fragment HEF42VIM22²
Cyclin T2a²		Subunit Of Positive Elongation Transcription Factor B²
Cyclin T2b²		CycT2³

External Ids:	HGNC: 1600¹	Entrez Gene: 905²	Ensembl: ENSG00000082258⁷	OMIM: 603862⁵	UniProtKB: O60583³

ORGUL members:
	NONCODE:n410507

Export aliases for CCNT2 gene to outside databases

Previous GC identifers: GC02P133321 GC02P133964 GC02P135887 GC02P135509 GC02P135392 GC02P127668

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNT2:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a

dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination

of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription

elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a

negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on

chromosome 1. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583

Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive

transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production

elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II)

Gene Wiki entry for CCNT2 (Cyclin T2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNT2 gene promoter:
AML1a Sp1 FOXF2 NRSF form 1 E47 POU2F1 POU2F1a Pax-4a NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CCNT2 promoter sequence

Search SABiosciences Chromatin IP Primers for CCNT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3 Ensembl cytogenetic band: 2q21.3 HGNC cytogenetic band: 2q21.3

CCNT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNT2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P135698: view genomic region (about GC identifiers)

Start:	135,675,805 bp from pter	End:	135,716,912 bp from pter
Size:	41,108 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583 (See protein sequence)

Recommended Name: Cyclin-T2

Size: 730 amino acids; 81029 Da

Subunit: Associates with CDK9 to form P-TEFb. Isoform 1 and isoform 2 interact with HIV-2 and SIV Tat. Does not bind

efficiently to the transactivation domain of the HIV-1 Tat

Subcellular location: Nucleus

1 PDB 3D structure from and Proteopedia for CCNT2:

2IVX (3D)

Secondary accessions: A8KA48 D3DP73 D3DP74 O60582 Q29R66 Q53SR4 Q5I1Y0

Alternative splicing: 2 isoforms: O60583-1 O60583-2

Explore the universe of human proteins at neXtProt for CCNT2: NX_O60583

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60583

CCNT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001232.1 NP_490595.1

ENSEMBL proteins:

ENSP00000404653 ENSP00000399497 ENSP00000400298 ENSP00000295238 ENSP00000264157

ENSP00000402512 ENSP00000387436 ENSP00000415120 ENSP00000439506

Reactome Protein details: O60583
Human Recombinant Protein Products:

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	Novus Biologicals CCNT2 Protein Novus Biologicals CCNT2 Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CCNT2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16109376
GO:0005654	nucleoplasm	TAS	--

CCNT2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCNT2 for domains About GeneDecksing

3 InterPro domains/families:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR015429 Cyclin_C/H/T/L

Graphical View of Domain Structure for InterPro Entry O60583

ProtoNet protein and cluster: O60583

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583

Similarity: Belongs to the cyclin family. Cyclin C subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583

Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive

transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production

elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II)

miRNA Products:		miRTarBase miRNAs that target CCNT2: hsa-mir-16 (MIRT001801)

		OriGene 3'-UTR Clone (see all 2): CCNT2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNT2
		8/224 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNT2 (see all 224):
		hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-106a hsa-miR-938 hsa-miR-128 hsa-miR-1245 hsa-miR-138-2*

		SwitchGear 3'UTR luciferase reporter plasmid: CCNT2 3' UTR sequence

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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNT2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019901	protein kinase binding	IEA	--

CCNT2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CCNT2:

Increased HPV18 LCR reporter a

Increased cell death in breast

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ccnt2):

mortality/aging

CCNT2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of RNA Pol II elongation complex

RNA Polymerase II Transcription Elongation	1.00	Pausing and recovery of HIV-1 elongation	0.74
Formation of HIV-1 elongation complex in the absence of HIV-1 Tat	1.00	Elongation arrest and recovery	0.74
Formation of RNA Pol II elongation complex	1.00	RNA Polymerase II Pre-transcription Events	0.72
HIV-1 elongation arrest and recovery	0.74	Transcription of the HIV genome	0.70

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	1.00			Signaling by TGF-beta Receptor Complex	0.61
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.63

Transcription

Transcription

1.00

RNA Polymerase II Transcription

0.69

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Late Phase of HIV Life Cycle

Late Phase of HIV Life Cycle

1.00

HIV Life Cycle

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNT2

	Breast Cancer Regulation by Stathmin1
	Pancreatic Adenocarcinoma

5/20 Reactome Pathways for CCNT2 (see all 20)

	Formation of RNA Pol II elongation complex
	Late Phase of HIV Life Cycle
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	RNA Polymerase II Transcription
	Disease

CCNT2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for CCNT2 (O60583³ ENSP00000264157⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BRD4	O60885³, ENSP00000263377⁴	I2D: score=2 STRING: ENSP00000263377
MEPCE	Q7L2J0³, ENSP00000308546⁴	I2D: score=1 STRING: ENSP00000308546
MLLT3	P42568³, ENSP00000369695⁴	I2D: score=1 STRING: ENSP00000369695
CDK9	P50750³, ENSP00000362361⁴	I2D: score=5 STRING: ENSP00000362361
PKN1	Q16512³, ENSP00000343325⁴	I2D: score=2 STRING: ENSP00000343325

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	IEA	--
GO:0006351	transcription, DNA-dependent	TAS	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--

CCNT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCNT2
Search CenterWatch for drugs/clinical trials and news about CCNT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCNT2 gene (2 alternative transcripts):

NM_001241.3 NM_058241.2

Unigene Cluster for CCNT2:

Cyclin T2

Hs.744115 [show with all ESTs]

Unigene Representative Sequence: NM_058241

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000419781 ENST00000446247 ENST00000452839 ENST00000295238 ENST00000264157(uc010zbf.2 uc002tub.2 uc002tuc.2 uc002tud.2)

ENST00000475094 ENST00000464932 ENST00000417175 ENST00000452521 ENST00000438691

ENST00000537343

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		hsa-miR-194* hsa-miR-411* hsa-miR-579 hsa-miR-106a hsa-miR-938 hsa-miR-128 hsa-miR-1245 hsa-miR-138-2*

		SwitchGear 3'UTR luciferase reporter plasmid: CCNT2 3' UTR sequence

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Additional cDNA sequence:

AF048731.1 AF048732.1 AK023645.1 AK075041.1 AK292913.1 AK294889.1 BC114366.2 BX648174.1

NR_037649.1

13 DOTS entries:

DT.114190 DT.75127817 DT.100672775 DT.95248449 DT.95200382 DT.92423498 DT.121642210 DT.120938115

DT.75141944 DT.100783657 DT.114191 DT.86837919 DT.91640590

24/184 AceView cDNA sequences (see all 184):

CB128783 AA767019 BE644772 AW662502 BX474808 AA330452 AW182918 BX489822

AA732241 BU184415 AI334118 CA390157 AW152646 AA723794 BG943619 BG435030

AI806736 BX471937 AA747539 BM709798 AA831390 CA946761 AI061460 AI559232

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CCNT2 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	·	9d	^	10	^	11a	·	11b	·
SP1:																					-		-						-										-
SP2:																					-		-		-		-		-				-		-		-		-
SP3:																					-		-		-		-		-				-		-		-		-
SP4:																					-		-						-				-		-		-		-
SP5:																					-

ExUns:	11c	^	12a	·	12b	·	12c	·	12d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CCNT2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCNT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See CCNT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNT2

SOURCE GeneReport for Unigene cluster: Hs.744115

UniProtKB/Swiss-Prot: CCNT2_HUMAN, O60583

Tissue specificity: Ubiquitously expressed

SABiosciences Custom PCR Arrays for CCNT2

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNT2 gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCNT2¹	cyclin T2	81.93(n) 84.53(a)		424289 XM_422134.3 XP_422134.3
lizard (Anolis carolinensis)	Reptilia	CCNT2⁶	--	67(a)	1 ↔ 1	1(96449041-96462210)
African clawed frog (Xenopus laevis)	Amphibia	CA791672.1²	--	85.24(n)		CA791672.1
zebrafish (Danio rerio)	Actinopterygii	BC044378.1²	--	82.31(n)		327568 BC044378.1
fruit fly (Drosophila melanogaster)	Insecta	CycT³	response to heat transcription elongation factor	59(a)		74D4 --
worm (Caenorhabditis elegans)	Secernentea	cit-1.1⁶ cit-1.2⁶	Cyclin-T1.2	21(a) 17(a)	many ↔ many many ↔ many	III(8005761-8009758) III(8010713-8013706)
thale cress (Arabidopsis thaliana)	eudicotyledons	CYCT1;1⁶ CYCT1;3⁶ (see all 5)	cyclin-T1-3 (see all 5)	28(a) 23(a) (see all 5)	many ↔ many many ↔ many (see all 5)	1(13035294-13036037) 1(9611103-9614336)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	cyclin-T1-1, putative, expressed (see all 3)	18(a) 18(a) (see all 3)	many ↔ many many ↔ many (see all 3)	12(17927216-17935779) 2(1733994-1737711)

ENSEMBL Gene Tree for CCNT2 (if available)
TreeFam Gene Tree for CCNT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCNT2 gene

CCNL2² CCNK² CCNC² CCNL1² CCNT1² FAM58A²

3 SIMAP similar genes for CCNT2 using alignment to 7 protein entries: CCNT2_HUMAN (see all proteins):

CYCT1b CCNK CCNT1

CCNT2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CCNT2
PGOHUM00000244141

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs45617231^1,2	C,F,	--	127666197(+)	`TTTTTA/TAAAAA`	3	--	us2k¹		2		NS WA	286
rs74944153^1,2		--	127666237(+)	`GCCCAC/GGCTGG`	3	--	us2k¹		0	--	--	--	--
rs45458504^1,2	C,F,	--	127666450(+)	`TGCAGT/CATGCT`	3	--	us2k¹		2		NS WA	290
rs45441399^1,2	C,	--	127666456(+)	`ATGCTG/AAGCGT`	3	--	us2k¹		1		NS	172
rs45586534^1,2	C,F,	--	127666663(+)	`CGCCAC/GCAAAC`	3	--	us2k¹		2		NS WA	290
rs45530638^1,2	C,F,	--	127667152(+)	`GATAAT/CGTAGG`	3	--	us2k¹		2		NS WA	276
rs41449851^1,2	C,F,	--	127667212(+)	`CACTCT/CTTCCC`	3	--	us2k¹		13		NS WA NA EA	1186
rs45523237^1,2	C,F,	--	127667261(+)	`TGTTGG/ATGGCG`	3	--	us2k¹		3		NS WA NA	392
rs41362150^1,2	C,F,	--	127667940(+)	`CAAAAG/CACTAG`	3	--	us2k¹		8		NS WA	936
rs45611231^1,2	F	--	127668103(+)	`GCGGGC/GGGAGG`	3	--	ut5¹ nc-transcript-variant		1		NS	160

HapMap Linkage Disequilibrium report for CCNT2 (135675805 - 135716912 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNT2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCNT2 for disorders           About GeneDecksing

OMIM gene information: 603862    OMIM disorders: --

9 diseases for CCNT2:    About MalaCards

immunodeficiency rhabdomyosarcoma colon carcinoma carcinoma

malaria leukemia breast cancer adenocarcinoma

pancreatitis

1 Novoseek disease relationship for CCNT2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	32	1	10049833 (1)

Human Genome Epidemiology (HuGE) Navigator: CCNT2 (1 document)

Export disorders for CCNT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCNT2 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with CCNT2)

Utopia: connect your pdf to the dynamic
world of online information

Identification of multiple cyclin subunits of human P-TEFb. (PubMed id 9499409)^{1, 2, 3, 9} Peng J.-M.... Price D.H. (1998)
The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity. (PubMed id 10465067)^{1, 3, 9} Napolitano G....Lania L. (1999)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. (PubMed id 10364329)^{1, 2} Bieniasz P.D.... Cullen B.R. (1999)
Pkn is a novel partner of cyclin T2a in muscle differentiation. (PubMed id 16331689)^{1, 9} Cottone G....De Luca A. (2006)
Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. (PubMed id 10329126)^{1, 9} Kwak Y.T.... Gaynor R.B. (1999)
Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. (PubMed id 10049833)^{1, 9} Wimmer J....Peterlin B.M. (1999)
Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb. (PubMed id 15563843)^{1, 9} Kurosu T....Peterlin B.M. (2004)
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. (PubMed id 18566585)^{1, 9} Baumli S....Johnson L.N. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 905	HGNC: 1600	AceView: CCNT2	Ensembl:ENSG00000082258	euGenes: HUgn905
ECgene: CCNT2	H-InvDB: CCNT2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCNT2	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccnt2/

Intellectual Property for CCNT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCNT2 gene:
Search GeneIP for patents involving CCNT2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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