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Aliases for CCNT2 Gene

Aliases for CCNT2 Gene

  • Cyclin T2 2 3 5
  • CYCT2 3 4
  • Subunit Of Positive Elongation Transcription Factor B 3
  • SDS-Stable Vimentin-Bound DNA Fragment HEF42VIM22 3
  • Cyclin T2a 3
  • Cyclin T2b 3

External Ids for CCNT2 Gene

Previous GeneCards Identifiers for CCNT2 Gene

  • GC02P133321
  • GC02P133964
  • GC02P135698
  • GC02P135887
  • GC02P135509
  • GC02P135392
  • GC02P127668

Summaries for CCNT2 Gene

Entrez Gene Summary for CCNT2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

GeneCards Summary for CCNT2 Gene

CCNT2 (Cyclin T2) is a Protein Coding gene. Diseases associated with CCNT2 include hiv-1. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNT1.

UniProtKB/Swiss-Prot for CCNT2 Gene

  • Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involded in early embryo development (By similarity).

  • (Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters.

Gene Wiki entry for CCNT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNT2 Gene

Genomics for CCNT2 Gene

Regulatory Elements for CCNT2 Gene

Promoters for CCNT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNT2 Gene

Chromosome:
2
Start:
134,918,235 bp from pter
End:
134,959,345 bp from pter
Size:
41,111 bases
Orientation:
Plus strand

Genomic View for CCNT2 Gene

Genes around CCNT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNT2 Gene

Proteins for CCNT2 Gene

  • Protein details for CCNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60583-CCNT2_HUMAN
    Recommended name:
    Cyclin-T2
    Protein Accession:
    O60583
    Secondary Accessions:
    • A8KA48
    • D3DP73
    • D3DP74
    • O60582
    • Q29R66
    • Q53SR4
    • Q5I1Y0

    Protein attributes for CCNT2 Gene

    Size:
    730 amino acids
    Molecular mass:
    81029 Da
    Quaternary structure:
    • Interacts with CDK9 to form P-TEFb (PubMed:9499409, PubMed:16331689). Interacts with POLR2A (via the C-terminal domain (CTD)); mediates transcriptional activity (PubMed:15563843). Interacts with HEXIM1; mediates formation of a tripartite complex with KPNA2. Interacts with HEXIM2 (PubMed:19883659). Interacts with PKN1; enhances MYOD1-dependent transcription (PubMed:16331689). P-TEFB complex interacts with RB1; promotes phosphorylation of RB1 (PubMed:12037672). P-TEFB complex interacts with MYOD1; promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation (By similarity). Interacts with MDFI and MDFIC (PubMed:17289077). Interacts with MON1B; downregulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection (PubMed:21509660).
    • (Microbial infection) Interacts with HIV-2 and SIV Tat. Does not bind efficiently to the transactivation domain of the HIV-1 Tat (PubMed:10364329).

    Three dimensional structures from OCA and Proteopedia for CCNT2 Gene

    Alternative splice isoforms for CCNT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNT2 Gene

Proteomics data for CCNT2 Gene at MOPED

Post-translational modifications for CCNT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CCNT2 Gene

Domains & Families for CCNT2 Gene

Gene Families for CCNT2 Gene

Protein Domains for CCNT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNT2 Gene

Graphical View of Domain Structure for InterPro Entry

O60583

UniProtKB/Swiss-Prot:

CCNT2_HUMAN :
  • Contains 1 cyclin N-terminal domain.
  • Belongs to the cyclin family. Cyclin C subfamily.
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.
genes like me logo Genes that share domains with CCNT2: view

Function for CCNT2 Gene

Molecular function for CCNT2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involded in early embryo development (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters.

Gene Ontology (GO) - Molecular Function for CCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9499409
GO:0019901 protein kinase binding IPI 16331689
GO:0097322 7SK snRNA binding IDA 11713533
genes like me logo Genes that share ontologies with CCNT2: view
genes like me logo Genes that share phenotypes with CCNT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCNT2

miRNA for CCNT2 Gene

miRTarBase miRNAs that target CCNT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNT2 Gene

Localization for CCNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNT2 Gene

Cytoplasm, perinuclear region. Nucleus. Note=Nucleus in differentiating cells. {ECO:0000250 UniProtKB:Q7TQK0}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNT2 Gene COMPARTMENTS Subcellular localization image for CCNT2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for CCNT2 Gene

Pathways & Interactions for CCNT2 Gene

genes like me logo Genes that share pathways with CCNT2: view

Pathways by source for CCNT2 Gene

1 GeneTex pathway for CCNT2 Gene

Gene Ontology (GO) - Biological Process for CCNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with CCNT2: view

No data available for SIGNOR curated interactions for CCNT2 Gene

Drugs & Compounds for CCNT2 Gene

No Compound Related Data Available

Transcripts for CCNT2 Gene

Unigene Clusters for CCNT2 Gene

Cyclin T2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ·
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: -
SP6: - - -
SP7: - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - -
SP10:
SP11: -
SP12: -
SP13:

ExUns: 11c ^ 12a · 12b · 12c · 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for CCNT2 Gene

GeneLoc Exon Structure for
CCNT2
ECgene alternative splicing isoforms for
CCNT2

Expression for CCNT2 Gene

mRNA expression in normal human tissues for CCNT2 Gene

Protein differential expression in normal tissues from HIPED for CCNT2 Gene

This gene is overexpressed in Pancreatic juice (48.4) and Pancreas (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNT2 Gene



SOURCE GeneReport for Unigene cluster for CCNT2 Gene Hs.744115

mRNA Expression by UniProt/SwissProt for CCNT2 Gene

O60583-CCNT2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with CCNT2: view

Protein tissue co-expression partners for CCNT2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CCNT2 Gene

Orthologs for CCNT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNT2 36
  • 100 (a)
OneToOne
CCNT2 35
  • 99.77 (n)
  • 99.86 (a)
cow
(Bos Taurus)
Mammalia CCNT2 36
  • 94 (a)
OneToOne
CCNT2 35
  • 95.19 (n)
  • 94.78 (a)
dog
(Canis familiaris)
Mammalia CCNT2 35
  • 95.71 (n)
  • 96.71 (a)
CCNT2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnt2 36
  • 88 (a)
OneToOne
Ccnt2 16
Ccnt2 35
  • 86.06 (n)
  • 86.25 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNT2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNT2 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnt2 35
  • 85.3 (n)
  • 84.98 (a)
chicken
(Gallus gallus)
Aves CCNT2 35
  • 81.14 (n)
  • 83.13 (a)
CCNT2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNT2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnt2 35
  • 75.74 (n)
  • 76.53 (a)
Str.6760 35
zebrafish
(Danio rerio)
Actinopterygii ccnt2a 36
  • 62 (a)
OneToMany
ccnt2b 36
  • 59 (a)
OneToMany
-- 35
ccnt2a 35
  • 66.42 (n)
  • 67.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycT 37
  • 59 (a)
CycT 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cit-1.1 36
  • 25 (a)
ManyToMany
cit-1.2 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToMany
Species with no ortholog for CCNT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNT2 Gene

ENSEMBL:
Gene Tree for CCNT2 (if available)
TreeFam:
Gene Tree for CCNT2 (if available)

Paralogs for CCNT2 Gene

Paralogs for CCNT2 Gene

(3) SIMAP similar genes for CCNT2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CCNT2 Gene

genes like me logo Genes that share paralogs with CCNT2: view

Variants for CCNT2 Gene

Sequence variations from dbSNP and Humsavar for CCNT2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1947112 -- 134,958,387(-) TACTG(C/T)CTCCC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1979033 -- 134,947,988(-) TTCAT(C/T)TGATA intron-variant
rs1984559 -- 134,921,318(+) AAATG(A/G)TCTAG intron-variant
rs2305153 -- 134,939,154(-) TTCTT(C/G)AATAA intron-variant
rs2034261 -- 134,949,188(-) CAAAA(A/C)TTAGC intron-variant

Variation tolerance for CCNT2 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNT2 Gene

HapMap Linkage Disequilibrium report
CCNT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCNT2 Gene

Disorders for CCNT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCNT2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search CCNT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNT2

Genetic Association Database (GAD)
CCNT2
Human Genome Epidemiology (HuGE) Navigator
CCNT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNT2
genes like me logo Genes that share disorders with CCNT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNT2 Gene

Publications for CCNT2 Gene

  1. Identification of multiple cyclin subunits of human P-TEFb. (PMID: 9499409) Peng J.-M. … Price D.H. (Genes Dev. 1998) 2 3 4 23 67
  2. The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity. (PMID: 10465067) Napolitano G. … Lania L. (AIDS 1999) 2 3 23
  3. The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation. (PMID: 18566585) Baumli S. … Johnson L.N. (EMBO J. 2008) 3 23
  4. Pkn is a novel partner of cyclin T2a in muscle differentiation. (PMID: 16331689) Cottone G. … De Luca A. (J. Cell. Physiol. 2006) 3 23
  5. Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb. (PMID: 15563843) Kurosu T. … Peterlin B.M. (Gene 2004) 3 23

Products for CCNT2 Gene

Sources for CCNT2 Gene

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