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CCNT1 Gene

protein-coding   GIFtS: 60
GCID: GC12M049093

Cyclin T1

(Previous name: human immunodeficiency virus type 1 (HIV-1) expression (elevated)...)
(Previous symbol: HIVE1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin T11 2     CDK9-Associated C-Type Protein2
HIVE11 2     Cyclin C-Related Protein2
Human Immunodeficiency Virus Type 1 (HIV-1) Expression (Elevated) 11 2     cyclin-T12
CCNT2 5     CycT13
CYCT12     Cyclin-T3

External Ids:    HGNC: 15991   Entrez Gene: 9042   Ensembl: ENSG000001293157   OMIM: 1430555   UniProtKB: O605633   

Export aliases for CCNT1 gene to outside databases

Previous GC identifers: GC12M049053 GC12M048803 GC12M047373 GC12M047372 GC12M049086 GC12M046120 GC12M049087


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNT1 Gene:
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with
cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In
humans, there are multiple forms of positive transcription elongation factor b, which may include one of several
different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and
cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is
both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are
also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the
largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Apr 2013)

GeneCards Summary for CCNT1 Gene:
CCNT1 (cyclin T1) is a protein-coding gene. Diseases associated with CCNT1 include hiv-1, and human immunodeficiency virus infectious disease. GO annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is CCNL2.

UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive
transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to
productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase
II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear
transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element
(TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of
viral genes

Gene Wiki entry for CCNT1 (Cyclin T1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNT1 gene promoter:
         CREB   RP58   NRSF form 1   deltaCREB   IRF-7A   NRSF form 2   MRF-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNT1 promoter sequence
   Search Chromatin IP Primers for CCNT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.11

CCNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNT1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049093:  view genomic region     (about GC identifiers)

Start:
49,082,247 bp from pter      End:
49,110,781 bp from pter
Size:
28,535 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563 (See protein sequence)
Recommended Name: Cyclin-T1  
Size: 726 amino acids; 80685 Da
Subunit: Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb
forms a complex with AFF4/AF5Q31. Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat.
Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and
NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and
CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with BRD4, probably to
target chromatin binding. Interacts with MDFIC
Miscellaneous: Interaction between Tat and cyclin-T1 requires zinc
Selected PDB 3D structures from and Proteopedia for CCNT1 (see all 19):
2PK2 (3D)        3BLH (3D)        3BLQ (3D)        3BLR (3D)        3LQ5 (3D)        3MI9 (3D)    
Secondary accessions: O60581

Explore the universe of human proteins at neXtProt for CCNT1: NX_O60563

Explore proteomics data for CCNT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCNT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231.2  NP_001264771.1  

    ENSEMBL proteins: 
     ENSP00000261900   ENSP00000399845  
    Reactome Protein details: O60563

    CCNT1 Human Recombinant Protein Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR015429 Cyclin_C/H/T/L
     IPR028863 CCNT1

    Graphical View of Domain Structure for InterPro Entry O60563

    ProtoNet protein and cluster: O60563

    UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    CCNT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNT1_HUMAN, O60563
    Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive
    transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to
    productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase
    II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear
    transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element
    (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of
    viral genes

         Genatlas biochemistry entry for CCNT1:
    cyclin T1,87kDa,associating with the transcription elongation factor CDK9,interacting with HIV-1Tat and mediating
    its high affinity to TAR

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16109376
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI12944466
    GO:0017069snRNA binding IEA--
    GO:0019901protein kinase binding IEA--
         
    CCNT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCNT1:
     Decreased p24 protein expressi  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCNT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNT1

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    miRTarBase miRNAs that target CCNT1:
    hsa-mir-27b-3p (MIRT006547), hsa-mir-198 (MIRT004603)

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    Search for qRT-PCR Assays for microRNAs that regulate CCNT1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNT1

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    OriGene ORF clones in mouse, rat for CCNT1
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    GenScript: all cDNA clones in your preferred vector: CCNT1 (NM_001240)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNT1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNT1_HUMAN, O60563: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0008024positive transcription elongation factor complex b IDA15905409

    CCNT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNT1 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    2Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.77
    Pausing and recovery of HIV elongation0.73
    HIV Transcription Elongation0.77
    HIV elongation arrest and recovery0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Polymerase II Transcription Elongation0.75
    Tat-mediated HIV elongation arrest and recovery0.72
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    4GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    Breast Cancer Regulation by Stathmin10.58
    5Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNT1
        Breast Cancer Regulation by Stathmin1
    GADD45 Pathway
    Pancreatic Adenocarcinoma

    1 Cell Signaling Technology (CST) Pathway for CCNT1
        Chromatin Regulation / Acetylation

    Selected Reactome Pathways for CCNT1 (see all 12)
        Pausing and recovery of Tat-mediated HIV elongation
    Formation of RNA Pol II elongation complex
    Tat-mediated HIV elongation arrest and recovery
    Interactions of Tat with host cellular proteins
    Tat-mediated elongation of the HIV-1 transcript


    1 Kegg Pathway  (Kegg details for CCNT1):
        Transcriptional misregulation in cancer


    CCNT1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNT1: 
              HIV Host Response in human mouse rat
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNT1 (O605631, 2, 3 ENSP000002619004) via UniProtKB, MINT, STRING, and/or I2D (see all 713)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HEXIM1O949922, 3, ENSP000003287734MINT-6629492 MINT-6629521 MINT-6629505 MINT-7266411 MINT-6629464 MINT-6629479 MINT-7266429 MINT-6629547 MINT-6629534 I2D: score=4 STRING: ENSP00000328773
    CDK9P507501, 2, 3, ENSP000003623614EBI-2479671,EBI-1383449 MINT-6629492 MINT-6629521 MINT-6629505 MINT-7266411 MINT-6629464 MINT-6799506 MINT-7945693 MINT-15817 MINT-6629561 MINT-6629479 MINT-7266429 MINT-6629547 MINT-6629534 I2D: score=6 STRING: ENSP00000362361
    SNW1Q135732, 3, ENSP000002615314MINT-7945693 I2D: score=1 STRING: ENSP00000261531
    LARP7Q4G0J32, ENSP000003143114MINT-6629492 MINT-6629521 MINT-6629505 MINT-6629464 MINT-6629479 MINT-6629534 STRING: ENSP00000314311
    AFF4Q9UHB71, 3, ENSP000002653434EBI-2479671,EBI-395282 I2D: score=3 STRING: ENSP00000265343
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    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    CCNT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNT1

    Selected Novoseek inferred chemical compound relationships for CCNT1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavopiridol 85.6 4 11431468 (1), 15972445 (1), 14751090 (1), 18566585 (1)
    roscovitine 76.2 9 19228744 (1), 17325859 (1), 17942543 (1)
    mdms 66.5 1 16330531 (1)
    phorbol 17.6 1 11739686 (1)
    cysteine 16.2 7 9990016 (2), 10329126 (1), 9832504 (1), 12692213 (1)
    lysine 13 4 17289077 (1), 10607594 (1), 12486002 (1), 19828451 (1)
    serine 12 1 15528190 (1)
    atp 0 3 10958691 (2)
    zinc 0 1 9832504 (1)
    tyrosine 0 5 9990016 (2), 10329126 (1)



    CCNT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCNT1 gene (2 alternative transcripts): 
    NM_001240.3  NM_001277842.1  

    Unigene Cluster for CCNT1:

    Cyclin T1
    Hs.92308  [show with all ESTs]
    Unigene Representative Sequence: NM_001240
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261900(uc001rsd.4 uc009zkz.2) ENST00000417344 ENST00000551989
    ENST00000550457
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF045161.1 AF048730.1 AK002085.1 AK290990.1 AL832083.1 BX537514.1 BX537516.1 

    7 DOTS entries:

    DT.95161009  DT.409213  DT.95155641  DT.40128020  DT.40269782  DT.114641  DT.40119559 

    3 AceView cDNA sequences:

    AF045161 NM_001240 AF048730 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAATTGAAG
    CCNT1 Expression
    About this image


    CCNT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CCNT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.92308

    UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNT1: 
              HIV Host Response in human mouse rat
              Cell Cycle in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCNT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNT1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCNT1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnt11 , 5 cyclin T11, 5 86.9(n)1
    89.79(a)1
      15 (54.54 cM)5
    124551  NM_009833.11  NP_033963.11 
     985386895 
    chicken
    (Gallus gallus)
    Aves CCNT11 cyclin T1 67.05(n)
    68.77(a)
      100859215  XM_003643378.2  XP_003643426.2 
    lizard
    (Anolis carolinensis)
    Reptilia CCNT16
    cyclin T1
    70(a)
    1 ↔ 1
    2(94551837-94562526)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.185052 Danio rerio, similar to cyclin T1, clone IMAGE2643435, more 75.28(n)    BC044435.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycT3 response to heat transcription
    elongation factor
    57(a)   74D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cit-1.16
    cit-1.26
    Protein CIT-1.2, isoform a
    25(a)
    24(a)
    many ↔ many
    many ↔ many
    III(8005826-8009821) WBGene00000507
    III(8010778-8013771) WBGene00000508


    ENSEMBL Gene Tree for CCNT1 (if available)
    TreeFam Gene Tree for CCNT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNT1 gene
    CCNL22  CCNT22  CCNK2  CCNC2  CCNL12  FAM58A2  
    2 SIMAP similar genes for CCNT1 using alignment to 1 protein entry:     CCNT1_HUMAN:
    CYCT1b    CCNT2

    CCNT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNT1 (see all 677)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473680111,2
    Cuntested149086999(+) AGCAGA/GGAGTG 3 S syn1 ut310--------
    rs794123261,2
    C,F--49081787(+) TCCAAC/TGGACT 2 -- ds50014Minor allele frequency- T:0.11WA CSA 124
    rs755445201,2
    C,F--49081788(+) CCAACG/AGACTC 2 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1473647281,2
    C--49081903(+) TGGACA/GCGGTG 2 -- ds50010--------
    rs1394056721,2
    C--49081905(+) GACGCA/GGTGGC 2 -- ds50010--------
    rs1927250401,2
    --49082101(+) GAACCC/TGGGAA 2 -- ds50010--------
    rs1453027751,2
    --49082127(+) AGCCGA/GGATCA 2 -- ds50010--------
    rs347706861,2
    C--49082178(+) GTCTC-/AAAAAA 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1845087751,2
    --49082228(+) ACATAA/GACAAC 2 -- ds50010--------
    rs1510014241,2
    C--49082270(+) TTGATA/GGGATG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CCNT1 (49082247 - 49110781 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCNT1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNT1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 143055    OMIM disorders: --

    Selected diseases for CCNT1 (see all 28):    
    About MalaCards
    hiv-1    human immunodeficiency virus infectious disease    werner syndrome    cytomegalovirus infection
    acquired immunodeficiency syndrome    stomatitis    vaccinia    brain cancer
    diffuse large b-cell lymphoma    vaginitis    b-cell lymphomas    lung adenocarcinoma
    intellectual disability    nasopharyngitis    influenza    t-cell leukemia
    chronic lymphocytic leukemia    tonsillitis    leukemia    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for CCNT1:
    Acquired immunodeficiency syndrome

    CCNT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    9 Novoseek inferred disease relationships for CCNT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 74.4 51 15254183 (2), 12368300 (2), 16439541 (2), 11739686 (2) (see all 39)
    equine infectious anemia 74.2 2 17540406 (1), 10683321 (1)
    vesicular stomatitis 40.6 1 16713742 (1)
    leukemia 20.1 2 15096811 (1), 12727882 (1)
    hiv infections 12.8 4 19886831 (1), 16330531 (1)
    lymphoma b-cell 7.92 1 15258998 (1)
    tumors 2.72 7 15753651 (1), 19228744 (1), 14751090 (1)
    leukemia lymphocytic chronic 2.02 1 17325859 (1)
    lymphoma 0 3 15258998 (2), 17325859 (1)

    Genetic Association Database (GAD): CCNT1
    Human Genome Epidemiology (HuGE) Navigator: CCNT1 (1 document)

    Export disorders for CCNT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CCNT1 gene, integrated from 10 sources (see all 374):
    (articles sorted by number of sources associating them with CCNT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of multiple cyclin subunits of human P-TEFb. (PubMed id 9499409)1, 2, 3, 9 Peng J.-M.... Price D.H. (Genes Dev. 1998)
    2. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. (PubMed id 9491887)1, 2, 3, 9 Wei P.... Jones K.A. (Cell 1998)
    3. Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1. (PubMed id 14972556)1, 2, 9 Das C.... Frankel A.D. (Virology 2004)
    4. Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation. (PubMed id 10329125)1, 2, 9 Ivanov D....Gaynor R.B. (J. Mol. Biol. 1999)
    5. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. (PubMed id 12944466)1, 2, 9 Young T.M.... Mathews M.B. (Mol. Cell. Biol. 2003)
    6. Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter. (PubMed id 10913173)1, 2, 9 Fong Y.W. and Zhou Q. (Mol. Cell. Biol. 2000)
    7. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. (PubMed id 9832504)1, 2, 9 Garber M.E.... Jones K.A. (Genes Dev. 1998)
    8. Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. (PubMed id 10329126)1, 2, 9 Kwak Y.T.... Gaynor R.B. (J. Mol. Biol. 1999)
    9. Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. (PubMed id 10364329)1, 2, 9 Bieniasz P.D.... Cullen B.R. (J. Virol. 1999)
    10. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1, 2 Jeronimo C.... Coulombe B. (Mol. Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 904 HGNC: 1599 AceView: CCNT1 Ensembl:ENSG00000129315 euGenes: HUgn904
    ECgene: CCNT1 Kegg: 904 H-InvDB: CCNT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCNT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCNT1 gene:
    Search GeneIP for patents involving CCNT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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