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Aliases for CCNT1 Gene

Aliases for CCNT1 Gene

  • Cyclin T1 2 3
  • Human Immunodeficiency Virus Type 1 (HIV-1) Expression (Elevated) 1 2 3
  • CYCT1 3 4
  • CCNT 3 6
  • CDK9-Associated C-Type Protein 3
  • Cyclin C-Related Protein 3
  • Cyclin-T1 3
  • Cyclin-T 4
  • HIVE1 3

External Ids for CCNT1 Gene

Previous Symbols for CCNT1 Gene

  • HIVE1

Summaries for CCNT1 Gene

Entrez Gene Summary for CCNT1 Gene

  • This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

GeneCards Summary for CCNT1 Gene

CCNT1 (Cyclin T1) is a Protein Coding gene. Diseases associated with CCNT1 include hiv-1. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is CCNT2.

UniProtKB/Swiss-Prot for CCNT1 Gene

  • Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tats affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.

Gene Wiki entry for CCNT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNT1 Gene

Genomics for CCNT1 Gene

Genomic Location for CCNT1 Gene

Start:
48,688,458 bp from pter
End:
48,716,998 bp from pter
Size:
28,541 bases
Orientation:
Minus strand

Genomic View for CCNT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNT1 Gene

Regulatory Elements for CCNT1 Gene

Proteins for CCNT1 Gene

  • Protein details for CCNT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60563-CCNT1_HUMAN
    Recommended name:
    Cyclin-T1
    Protein Accession:
    O60563
    Secondary Accessions:
    • A9XU13
    • E7EX76
    • O60581

    Protein attributes for CCNT1 Gene

    Size:
    726 amino acids
    Molecular mass:
    80685 Da
    Quaternary structure:
    • Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with BRD4, probably to target chromatin binding. Interacts with MDFIC.
    Miscellaneous:
    • Interaction between Tat and cyclin-T1 requires zinc

    Three dimensional structures from OCA and Proteopedia for CCNT1 Gene

    Alternative splice isoforms for CCNT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNT1 Gene

Proteomics data for CCNT1 Gene at MOPED

Post-translational modifications for CCNT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNT1 Gene

Domains for CCNT1 Gene

Protein Domains for CCNT1 Gene

UniProtKB/Swiss-Prot:

CCNT1_HUMAN
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.:
    • O60563
genes like me logo Genes that share domains with CCNT1: view

No data available for Gene Families for CCNT1 Gene

Function for CCNT1 Gene

Molecular function for CCNT1 Gene

GENATLAS Biochemistry: cyclin T1,87kDa,associating with the transcription elongation factor CDK9,interacting with HIV-1Tat and mediating its high affinity to TAR
UniProtKB/Swiss-Prot Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tats affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.

Gene Ontology (GO) - Molecular Function for CCNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16109376
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 12944466
GO:0017069 snRNA binding IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNT1: view

Phenotypes for CCNT1 Gene

genes like me logo Genes that share phenotypes with CCNT1: view

miRNA for CCNT1 Gene

miRTarBase miRNAs that target CCNT1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCNT1 Gene

Localization for CCNT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNT1 Gene COMPARTMENTS Subcellular localization image for CCNT1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CCNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12944466
GO:0005654 nucleoplasm TAS --
GO:0005730 NOT nucleolus IDA 16109376
GO:0008024 positive transcription elongation factor complex b IDA 15905409
genes like me logo Genes that share ontologies with CCNT1: view

Pathways for CCNT1 Gene

SuperPathways for CCNT1 Gene

Superpath Contained pathways
1 Loss of Function of SMAD2/3 in Cancer
2 Formation of RNA Pol II elongation complex
3 HIV Life Cycle
4 GPCR Pathway
5 Gene Expression
genes like me logo Genes that share pathways with CCNT1: view

Pathways by source for CCNT1 Gene

Gene Ontology (GO) - Biological Process for CCNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0006351 transcription, DNA-templated TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with CCNT1: view

Compounds for CCNT1 Gene

(11) Novoseek inferred chemical compound relationships for CCNT1 Gene

Compound -log(P) Hits PubMed IDs
flavopiridol 85.6 4
roscovitine 76.2 3
mdms 66.5 1
phorbol 17.6 1
cysteine 16.2 5
genes like me logo Genes that share compounds with CCNT1: view

Transcripts for CCNT1 Gene

mRNA/cDNA for CCNT1 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCNT1 Gene

Cyclin T1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNT1 Gene

No ASD Table

Relevant External Links for CCNT1 Gene

GeneLoc Exon Structure for
CCNT1
ECgene alternative splicing isoforms for
CCNT1

Expression for CCNT1 Gene

mRNA expression in normal human tissues for CCNT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNT1 Gene

SOURCE GeneReport for Unigene cluster for CCNT1 Gene Hs.92308

mRNA Expression by UniProt/SwissProt for CCNT1 Gene

O60563-CCNT1_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with CCNT1: view

Orthologs for CCNT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNT1 36
  • 99.76 (n)
  • 99.72 (a)
CCNT1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNT1 36
  • 90.43 (n)
  • 88.97 (a)
CCNT1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNT1 36
  • 93.63 (n)
  • 93.63 (a)
CCNT1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnt1 36
  • 86.9 (n)
  • 89.79 (a)
Ccnt1 16
Ccnt1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNT1 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNT1 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnt1 36
  • 83.85 (n)
  • 86.6 (a)
chicken
(Gallus gallus)
Aves CCNT1 36
  • 67.05 (n)
  • 68.77 (a)
CCNT1 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNT1 37
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5159 36
zebrafish
(Danio rerio)
Actinopterygii ccnt1 36
  • 59.39 (n)
  • 62.56 (a)
ccnt1 37
  • 56 (a)
OneToOne
Dr.18505 36
fruit fly
(Drosophila melanogaster)
Insecta CycT 37
  • 23 (a)
OneToMany
CycT 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea cit-1.1 37
  • 25 (a)
ManyToMany
cit-1.2 37
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 61 (a)
OneToMany
Species with no ortholog for CCNT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCNT1 Gene

ENSEMBL:
Gene Tree for CCNT1 (if available)
TreeFam:
Gene Tree for CCNT1 (if available)

Paralogs for CCNT1 Gene

Paralogs for CCNT1 Gene

Selected SIMAP similar genes for CCNT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCNT1: view

Variants for CCNT1 Gene

Sequence variations from dbSNP and Humsavar for CCNT1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3013 -- 48,693,873(+) CGCTC(C/G)GGGTT reference, synonymous-codon, utr-variant-3-prime
rs11534 -- 48,688,636(-) GTTAT(A/G)TGAAT utr-variant-3-prime
rs15105 -- 48,688,682(+) AGGTG(A/C)CCCAA utr-variant-3-prime
rs1110432 -- 48,716,465(-) ATGCT(C/T)TGGCG intron-variant
rs1316514 -- 48,715,855(+) TTCGT(A/G)GGTAT intron-variant

Relevant External Links for CCNT1 Gene

HapMap Linkage Disequilibrium report
CCNT1

No data available for Structural Variations from Database of Genomic Variants (DGV) for CCNT1 Gene

Disorders for CCNT1 Gene

(1) MalaCards Diseases for CCNT1 Gene

Search for CCNT1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CCNT1 Gene

(9) Novoseek inferred disease relationships for CCNT1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 74.4 44
equine infectious anemia 74.2 2
vesicular stomatitis 40.6 1
leukemia 20.1 2
hiv infections 12.8 2

Relevant External Links for CCNT1

Genetic Association Database (GAD)
CCNT1
Human Genome Epidemiology (HuGE) Navigator
CCNT1
genes like me logo Genes that share disorders with CCNT1: view

No data available for UniProtKB/Swiss-Prot for CCNT1 Gene

Publications for CCNT1 Gene

  1. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. (PMID: 9491887) Wei P. … Jones K.A. (Cell 1998) 2 3 4 23
  2. Identification of multiple cyclin subunits of human P-TEFb. (PMID: 9499409) Peng J.-M. … Price D.H. (Genes Dev. 1998) 2 3 4 23
  3. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. (PMID: 9832504) Garber M.E. … Jones K.A. (Genes Dev. 1998) 3 4 23
  4. Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation. (PMID: 10329125) Ivanov D. … Gaynor R.B. (J. Mol. Biol. 1999) 3 4 23
  5. Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. (PMID: 10329126) Kwak Y.T. … Gaynor R.B. (J. Mol. Biol. 1999) 3 4 23

Products for CCNT1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cell Cycle in human,mouse,rat
    • HIV Host Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCNT1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCNT1
    • Block miRNA regulation of CCNT1 using miScript Target Protectors
    • Addgene plasmids for CCNT1

    Sources for CCNT1 Gene

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