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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNT1 Gene

protein-coding   GIFtS: 61
GCID: GC12M049087

Cyclin T1

(Previous name: human immunodeficiency virus type 1 (HIV-1) expression (elevated)...)
(Previous symbol: HIVE1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin T11 2     CDK9-Associated C-Type Protein2
HIVE11 2     Cyclin C-Related Protein2
Human Immunodeficiency Virus Type 1 (HIV-1) Expression (Elevated) 11 2     cyclin-T12
CCNT2 5     CycT13
CYCT12     Cyclin-T3

External Ids:    HGNC: 15991   Entrez Gene: 9042   Ensembl: ENSG000001293157   OMIM: 1430555   UniProtKB: O605633   

Export aliases for CCNT1 gene to outside databases

Previous GC identifers: GC12M049053 GC12M048803 GC12M047373 GC12M047372 GC12M049086 GC12M046120


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNT1 Gene:
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with
cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In
humans, there are multiple forms of positive transcription elongation factor b, which may include one of several
different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and
cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is
both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are
also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the
largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Apr 2013)

GeneCards Summary for CCNT1 Gene: 
CCNT1 (cyclin T1) is a protein-coding gene. Diseases associated with CCNT1 include human immunodeficiency virus infectious disease, and hiv type 1, and among its related super-pathways are Formation of the Early Elongation Complex and HIV Life Cycle. GO annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is CCNL2.

UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive
transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to
productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase
II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear
transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element
(TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of
viral genes

Gene Wiki entry for CCNT1 (Cyclin T1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNT1 gene promoter:
         CREB   RP58   NRSF form 1   deltaCREB   IRF-7A   NRSF form 2   MRF-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.11

CCNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNT1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049087:  view genomic region     (about GC identifiers)

Start:
49,082,247 bp from pter      End:
49,110,781 bp from pter
Size:
28,535 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563 (See protein sequence)
Recommended Name: Cyclin-T1  
Size: 726 amino acids; 80685 Da
Subunit: Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb
forms a complex with AFF4/AF5Q31. Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat.
Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and
NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and
CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with BRD4, probably to
target chromatin binding. Interacts with MDFIC
Subcellular location: Nucleus
Miscellaneous: Interaction between Tat and cyclin-T1 requires zinc
6/19 PDB 3D structures from and Proteopedia for CCNT1 (see all 19):
2PK2 (3D)        3BLH (3D)        3BLQ (3D)        3BLR (3D)        3LQ5 (3D)        3MI9 (3D)    
Secondary accessions: O60581

Explore the universe of human proteins at neXtProt for CCNT1: NX_O60563

Explore proteomics data for CCNT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60563

  • CCNT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNT1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231.2  NP_001264771.1  

    ENSEMBL proteins: 
     ENSP00000261900   ENSP00000399845  
    Reactome Protein details: O60563
    Human Recombinant Protein Products for CCNT1: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0008024positive transcription elongation factor complex b IDA15905409

    CCNT1 for ontologies           About GeneDecksing



    CCNT1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR015429 Cyclin_C/H/T/L

    Graphical View of Domain Structure for InterPro Entry O60563

    ProtoNet protein and cluster: O60563

    UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    CCNT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNT1_HUMAN, O60563
    Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive
    transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to
    productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase
    II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear
    transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element
    (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of
    viral genes

         Genatlas biochemistry entry for CCNT1:
    cyclin T1,87kDa,associating with the transcription elongation factor CDK9,interacting with HIV-1Tat and mediating
    its high affinity to TAR

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16109376
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI12944466
    GO:0017069snRNA binding IEA--
    GO:0019901protein kinase binding IEA--
         
    CCNT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCNT1:
     Decreased p24 protein expressi  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNT1

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    miRTarBase miRNAs that target CCNT1:
    hsa-mir-198 (MIRT004603)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCNT1 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.78
    HIV elongation arrest and recovery0.74
    HIV Transcription Elongation0.78
    Pausing and recovery of HIV elongation0.74
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.78
    Pausing and recovery of Tat-mediated HIV elongation0.73
    Formation of HIV elongation complex in the absence of HIV Tat0.76
    Tat-mediated HIV elongation arrest and recovery0.73
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    3Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Signaling by TGF-beta Receptor Complex0.61
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    Breast Cancer Regulation by Stathmin10.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNT1
        Breast Cancer Regulation by Stathmin1
    GADD45 Pathway
    Pancreatic Adenocarcinoma

    1 Cell Signaling Technology (CST) Pathway for CCNT1
        Chromatin Regulation / Acetylation

    5/27        Reactome Pathways for CCNT1 (see all 27)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle


    1         Kegg Pathway  (Kegg details for CCNT1):
        Transcriptional misregulation in cancer


    CCNT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/665 Interacting proteins for CCNT1 (O605631, 2, 3 ENSP000002619004) via UniProtKB, MINT, STRING, and/or I2D (see all 665)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HEXIM1O949922, 3, ENSP000003287734MINT-6629492 MINT-6629521 MINT-6629505 MINT-7266411 MINT-6629464 MINT-6629479 MINT-7266429 MINT-6629547 MINT-6629534 I2D: score=4 STRING: ENSP00000328773
    CDK9P507502, 3, ENSP000003623614MINT-6629492 MINT-6629521 MINT-6629505 MINT-7266411 MINT-6629464 MINT-6799506 MINT-7945693 MINT-15817 MINT-6629561 MINT-6629479 MINT-7266429 MINT-6629547 MINT-6629534 I2D: score=6 STRING: ENSP00000362361
    SNW1Q135732, 3, ENSP000002615314MINT-7945693 I2D: score=1 STRING: ENSP00000261531
    LARP7Q4G0J32, ENSP000003143114MINT-6629492 MINT-6629521 MINT-6629505 MINT-6629464 MINT-6629479 MINT-6629534 STRING: ENSP00000314311
    AFF4Q9UHB71, 3, ENSP000002653434EBI-2479671,EBI-395282 I2D: score=3 STRING: ENSP00000265343
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    CCNT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCNT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CCNT1

    10/11 Novoseek inferred chemical compound relationships for CCNT1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavopiridol 85.6 4 11431468 (1), 15972445 (1), 14751090 (1), 18566585 (1)
    roscovitine 76.2 9 19228744 (1), 17325859 (1), 17942543 (1)
    mdms 66.5 1 16330531 (1)
    phorbol 17.6 1 11739686 (1)
    cysteine 16.2 7 9990016 (2), 10329126 (1), 9832504 (1), 12692213 (1)
    lysine 13 4 17289077 (1), 10607594 (1), 12486002 (1), 19828451 (1)
    serine 12 1 15528190 (1)
    atp 0 3 10958691 (2)
    zinc 0 1 9832504 (1)
    tyrosine 0 5 9990016 (2), 10329126 (1)

    Search CenterWatch for drugs/clinical trials and news about CCNT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNT1 gene (2 alternative transcripts): 
    NM_001240.3  NM_001277842.1  

    Unigene Cluster for CCNT1:

    Cyclin T1
    Hs.92308  [show with all ESTs]
    Unigene Representative Sequence: NM_001240
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261900(uc001rsd.4 uc009zkz.2) ENST00000417344 ENST00000551989
    ENST00000550457
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF045161.1 AF048730.1 AK002085.1 AK290990.1 AL832083.1 BX537514.1 BX537516.1 

    7 DOTS entries:

    DT.95161009  DT.409213  DT.95155641  DT.40128020  DT.40269782  DT.114641  DT.40119559 

    3 AceView cDNA sequences:

    AF045161 NM_001240 AF048730 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNT1 expression in normal human tissues (normalized intensities)      CCNT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAATTGAAG
    CCNT1 Expression
    About this image


    CCNT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
             sperm   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             brain/hindbrain   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See CCNT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNT1

    SOURCE GeneReport for Unigene cluster: Hs.92308

    UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCNT1: 
              HIV Host Response in human mouse rat
              Cell Cycle in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNT1 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnt11 , 5 cyclin T11, 5 87.02(n)1
    90.06(a)1
      15 (54.54 cM)5
    124551  NM_009833.11  NP_033963.11 
     985386895 
    chicken
    (Gallus gallus)
    Aves LOC1008592151 cyclin-T1-like 67.16(n)
    69.33(a)
      100859215  XM_003643378.1  XP_003643426.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNT16
    Uncharacterized protein
    70(a)
    1 ↔ 1
    2(94551837-94562526)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.185052 Danio rerio, similar to cyclin T1, clone IMAGE2643435, more 75.28(n)    BC044435.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycT1 , 3 response to heat transcription
    elongation factor3
    Cyclin T1
    57(a)3
    45.19(n)1
    38.66(a)1
      74D43
    399611  NM_079403.31  NP_524127.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cit-1.21 Protein CIT-1.2 41.95(n)
    26.91(a)
      176126  NM_066344.3  NP_498745.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYCT1;41 cyclin-T1-4 44.56(n)
    31.33(a)
      827702  NM_118080.2  NP_193695.2 
    rice
    (Oryza sativa)
    Liliopsida Os12g04854001 hypothetical protein 48.43(n)
    35.51(a)
      4352229  NM_001073313.2  NP_001066781.1 


    ENSEMBL Gene Tree for CCNT1 (if available)
    TreeFam Gene Tree for CCNT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNT1 gene
    CCNL22  CCNT22  CCNK2  CCNC2  CCNL12  FAM58A2  
    2 SIMAP similar genes for CCNT1 using alignment to 1 protein entry:     CCNT1_HUMAN:
    CYCT1b    CCNT2

    CCNT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/677 SNPs in CCNT1 are shown (see all 677)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473680111,2
    Cuntested149086999(+) AGCAGA/GGAGTG 3 S syn1 ut310--------
    VAR_0694004
    ----see VAR_0694002 R C mis40--------
    rs794123261,2
    C,F--49081787(+) TCCAAC/TGGACT 2 -- ds50014Minor allele frequency- T:0.11WA CSA 124
    rs755445201,2
    C,F--49081788(+) CCAACG/AGACTC 2 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1473647281,2
    C--49081903(+) TGGACA/GCGGTG 2 -- ds50010--------
    rs1394056721,2
    C--49081905(+) GACGCA/GGTGGC 2 -- ds50010--------
    rs1927250401,2
    --49082101(+) GAACCC/TGGGAA 2 -- ds50010--------
    rs1453027751,2
    --49082127(+) AGCCGA/GGATCA 2 -- ds50010--------
    rs347706861,2
    C--49082178(+) GTCTC-/AAAAAA 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1845087751,2
    --49082228(+) ACATAA/GACAAC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCNT1 (49082247 - 49110781 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCNT1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNT1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 143055    OMIM disorders: --

    18 diseases for CCNT1:    About MalaCards
    human immunodeficiency virus infectious disease    hiv type 1    werner syndrome    cytomegalovirus infection
    vaccinia    diffuse large b-cell lymphoma    b-cell lymphomas    lung adenocarcinoma
    nasopharyngitis    influenza    anemia    t-cell leukemia
    chronic lymphocytic leukemia    leukemia    neuroblastoma    adenocarcinoma
    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CCNT1:
    Acquired immunodeficiency syndrome

    CCNT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    9 Novoseek inferred disease relationships for CCNT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 74.4 51 15254183 (2), 12368300 (2), 16439541 (2), 11739686 (2) (see all 39)
    equine infectious anemia 74.2 2 17540406 (1), 10683321 (1)
    vesicular stomatitis 40.6 1 16713742 (1)
    leukemia 20.1 2 15096811 (1), 12727882 (1)
    hiv infections 12.8 4 19886831 (1), 16330531 (1)
    lymphoma b-cell 7.92 1 15258998 (1)
    tumors 2.72 7 15753651 (1), 19228744 (1), 14751090 (1)
    leukemia lymphocytic chronic 2.02 1 17325859 (1)
    lymphoma 0 3 15258998 (2), 17325859 (1)

    Genetic Association Database (GAD): CCNT1
    Human Genome Epidemiology (HuGE) Navigator: CCNT1 (1 document)

    Export disorders for CCNT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNT1 gene, integrated from 9 sources (see all 372):
    (articles sorted by number of sources associating them with CCNT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of multiple cyclin subunits of human P-TEFb. (PubMed id 9499409)1, 2, 3, 9 Peng J.-M.... Price D.H. (1998)
    2. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. (PubMed id 9491887)1, 2, 3, 9 Wei P.... Jones K.A. (1998)
    3. Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1. (PubMed id 14972556)1, 2, 9 Das C.... Frankel A.D. (2004)
    4. Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation. (PubMed id 10329125)1, 2, 9 Ivanov D....Gaynor R.B. (1999)
    5. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. (PubMed id 12944466)1, 2, 9 Young T.M.... Mathews M.B. (2003)
    6. Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter. (PubMed id 10913173)1, 2, 9 Fong Y.W. and Zhou Q. (2000)
    7. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. (PubMed id 9832504)1, 2, 9 Garber M.E.... Jones K.A. (1998)
    8. Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. (PubMed id 10329126)1, 2, 9 Kwak Y.T.... Gaynor R.B. (1999)
    9. Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. (PubMed id 10364329)1, 2, 9 Bieniasz P.D.... Cullen B.R. (1999)
    10. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1, 2 Jeronimo C.... Coulombe B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 904 HGNC: 1599 AceView: CCNT1 Ensembl:ENSG00000129315 euGenes: HUgn904
    ECgene: CCNT1 Kegg: 904 H-InvDB: CCNT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNT1 gene:
    Search GeneIP for patents involving CCNT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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