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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNT1 Gene

protein-coding   GIFtS: 56
GCID: GC12M049086

cyclin T1

(Previous name: human immunodeficiency virus type 1 (HIV-1) expression...)
(Previous symbol: HIVE1)
 Explore 22 diseases affiliated with
CCNT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCNT1    

Aliases
for CCNT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin T11 2     Cyclin T1b2
CCNT1 2 5     Cyclin-T3
CYCT11 2     Cyclin-T11
HIVE11 2     Human Immunodeficiency Virus-1 Expression2
Human Immunodeficiency Virus Type 1 (HIV-1) Expression (Elevated) 11 2     Subunit Of Positive Elongation Transcription Factor B2
CDK9-Associated C-Type Protein2     CycT13
Cyclin C-Related Protein2     Cyclin-T3

External Ids:    HGNC: 15991   Entrez Gene: 9042   Ensembl: ENSG000001293157   OMIM: 1430555   UniProtKB: O605633   

Export aliases for CCNT1 gene to outside databases

Previous GC identifers: GC12M049053 GC12M048803 GC12M047373 GC12M047372 GC12M046120


Summaries
for CCNT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCNT1:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.
Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination
of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the
transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can
interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be
both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also
found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA
polymerase II subunit. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive
transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive
elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol
II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional
activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an
essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes

Gene Wiki entry for CCNT1 (Cyclin T1)


Genomic Views
for CCNT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNT1 gene promoter:
         CREB   RP58   NRSF form 1   deltaCREB   IRF-7A   NRSF form 2   MRF-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.11

CCNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNT1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049086:  view genomic region     (about GC identifiers)

Start:
 49,082,247 bp from pter      End:
 49,110,781 bp from pter
Size:
 28,535 bases      Orientation:
 minus strand

Proteins
for CCNT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563 (See protein sequence)
Recommended Name: Cyclin-T1  
Size: 726 amino acids; 80685 Da
Subunit: Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb
forms a complex with AFF4/AF5Q31. Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat. Component of
a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin.
Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2,
BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with MDFIC
Subcellular location: Nucleus
Miscellaneous: Interaction between Tat and cyclin-T1 requires zinc
6/17 PDB 3D structures from and Proteopedia for CCNT1 (see all 17):
2PK2 (3D)        3BLH (3D)        3BLQ (3D)        3BLR (3D)        3LQ5 (3D)        3MI9 (3D)    
Secondary accessions: O60581

Explore the universe of human proteins at neXtProt for CCNT1: NX_O60563

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60563

    • CCNT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001231.2  
    ENSEMBL proteins: 
     ENSP00000261900   ENSP00000399845  
    Reactome Protein details: O60563
    Human Recombinant Protein Products: 
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    Uscn Proteins for CCNT1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0008024positive transcription elongation factor complex b IDA15905409


    CCNT1 for ontologies           About GeneDecksing



    CCNT1 Antibody Products: 
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    Uscn Antibodies for CCNT1
    ThermoFisher Antibody for CCNT1

    Assay Products for CCNT1: 
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    Uscn ELISAs and CLIAs for CCNT1

    Protein Domains /
    Families
    for CCNT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCNT1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR015429 Cyclin_C/H/T/L

    Graphical View of Domain Structure for InterPro Entry O60563

    ProtoNet protein and cluster: O60563

    UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    Function
    for CCNT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
    Function: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive
    transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive
    elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol
    II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional
    activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an
    essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes

         Genatlas biochemistry entry for CCNT1:
    cyclin T1,87kDa,associating with the transcription elongation factor CDK9,interacting with HIV-1Tat and mediating its
    high affinity to TAR

    miRNA
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    hsa-mir-198 (MIRT004603)

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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNT1 (see all 7)
    OriGene shRNA RFP: CCNT1
    OriGene siRNA: CCNT1
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for CCNT1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNT1

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16109376
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI--
    GO:0017069snRNA binding IEA--
    GO:0019901protein kinase binding IEA--


    CCNT1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CCNT1:
     Decreased p24 protein expressi  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for CCNT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of RNA Pol II elongation complex
    8/13 pathways (see all 13)
    		RNA Polymerase II Transcription Elongation1.00
    		Pausing and recovery of HIV-1 elongation0.74
    		Formation of HIV-1 elongation complex in the absence of HIV-1 Tat1.00
    		Elongation arrest and recovery0.74
    		Formation of RNA Pol II elongation complex 1.00
    		RNA Polymerase II Pre-transcription Events0.72
    		Formation of HIV-1 elongation complex containing HIV-1 Tat0.98
    		Tat-mediated HIV-1 elongation arrest and recovery 0.71
    2Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    		Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer1.00
    		Signaling by TGF-beta Receptor Complex0.61
    		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    3Late Phase of HIV Life Cycle
    		Late Phase of HIV Life Cycle1.00
    		HIV Life Cycle0.90
    4HIV Infection
    		HIV Infection1.00
    		Host Interactions of HIV factors0.64
    5Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNT1
        Breast Cancer Regulation by Stathmin1
    GADD45 Pathway
    Pancreatic Adenocarcinoma

    1 Cell Signaling Technology (CST) Pathway for CCNT1
        Chromatin Regulation / Acetylation

    5/27        Reactome Pathways for CCNT1 (see all 27)
        Formation of RNA Pol II elongation complex
    Pausing and recovery of Tat-mediated HIV-1 elongation
    Tat-mediated HIV-1 elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Late Phase of HIV Life Cycle



    CCNT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/637 Interacting proteins for CCNT1 (O605631, 2, 3 ENSP000002619004) via UniProtKB, MINT, STRING, and/or I2D (see all 637)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HEXIM1O949922, 3, ENSP000003287734MINT-6629492 MINT-6629521 MINT-6629505 MINT-7266411 MINT-6629464 MINT-6629479 MINT-7266429 MINT-6629547 MINT-6629534 I2D: score=4 STRING: ENSP00000328773
    CDK9P507502, 3, ENSP000003623614MINT-6629492 MINT-6629521 MINT-6629505 MINT-7266411 MINT-6629464 MINT-6799506 MINT-7945693 MINT-15817 MINT-6629561 MINT-6629479 MINT-7266429 MINT-6629547 MINT-6629534 I2D: score=6 STRING: ENSP00000362361
    SNW1Q135732, 3, ENSP000002615314MINT-7945693 I2D: score=1 STRING: ENSP00000261531
    LARP7Q4G0J32, ENSP000003143114MINT-6629492 MINT-6629521 MINT-6629505 MINT-6629464 MINT-6629479 MINT-6629534 STRING: ENSP00000314311
    AFF4Q9UHB71, 3, ENSP000002653434EBI-2479671,EBI-1384303 I2D: score=3 STRING: ENSP00000265343
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity IEA--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--


    CCNT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCNT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCNT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNT1
    10/11 Novoseek chemical compound relationships for CCNT1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavopiridol 85.6 4 11431468 (1), 15972445 (1), 14751090 (1), 18566585 (1)
    roscovitine 76.2 9 19228744 (1), 17325859 (1), 17942543 (1)
    mdms 66.5 1 16330531 (1)
    phorbol 17.6 1 11739686 (1)
    cysteine 16.2 7 9990016 (2), 10329126 (1), 9832504 (1), 12692213 (1)
    lysine 13 4 17289077 (1), 10607594 (1), 12486002 (1), 19828451 (1)
    serine 12 1 15528190 (1)
    atp 0 3 10958691 (2)
    zinc 0 1 9832504 (1)
    tyrosine 0 5 9990016 (2), 10329126 (1)

    Search CenterWatch for drugs/clinical trials and news about CCNT1 

    Transcripts
    for CCNT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCNT1 gene: 
    NM_001240.3  

    Unigene Cluster for CCNT1:

    Cyclin T1
    Hs.92308  [show with all ESTs]
    Unigene Representative Sequence: NM_001240
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261900(uc001rsd.4 uc009zkz.2) ENST00000417344 ENST00000551989
    ENST00000550457

    miRNA
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    Clone
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    Additional cDNA sequence: 

    AF045161.1 AF048730.1 AK002085.1 AK290990.1 AL832083.1 BX537514.1 BX537516.1 

    7 DOTS entries:

    DT.95161009  DT.409213  DT.95155641  DT.40128020  DT.40269782  DT.114641  DT.40119559 

    3 AceView cDNA sequences:

    AF045161 NM_001240 AF048730 

    GeneLoc Exon Structure


    Expression
    for CCNT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAATTGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CCNT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNT1

    SOURCE GeneReport for Unigene cluster: Hs.92308

    UniProtKB/Swiss-Prot: CCNT1_HUMAN, O60563
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCNT1: 
              HIV Host Response in human mouse rat
              Cell Cycle in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CCNT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNT1 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008592151 cyclin-T1-like 67.16(n)
    69.33(a)    		   100859215  XM_003643378.1  XP_003643426.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CCNT16
    		 --
    		 55(a)
    		 1 ↔ 1
    		 2(94551855-94562526)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.185052 Danio rerio, similar to cyclin T1, clone IMAGE2643435, more 75.28(n)    BC044435.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CycT1 , 3 response to heat transcription elongation
    factor3
    Cyclin T1    		 57(a)3
    45.19(n)1
    38.66(a)1    		   74D43
    399611  NM_079403.31  NP_524127.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea cit-1.21 Protein CIT-1.2 41.95(n)
    26.91(a)    		   176126  NM_066344.3  NP_498745.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CYCT1;41 cyclin-T1-4 44.56(n)
    31.33(a)    		   827702  NM_118080.2  NP_193695.2 
    rice
    (Oryza sativa)    		 Liliopsida Os12g04854001 hypothetical protein 48.43(n)
    35.51(a)    		   4352229  NM_001073313.2  NP_001066781.1 


    ENSEMBL Gene Tree for CCNT1 (if available)
    TreeFam Gene Tree for CCNT1 (if available) 

    Paralogs
    for CCNT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNT1 gene
    CCNT22  CCNL22  CCNK2  CCNC2  CCNL12  FAM58A2  
    2 SIMAP similar genes for CCNT1 using alignment to 1 protein entry:     CCNT1_HUMAN:
    CYCT1b    CCNT2

    CCNT1 for paralogs           About GeneDecksing



    Genomic Variants
    for CCNT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/554 NCBI SNPs in CCNT1 are shown (see all 554)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs45160161,2
    		C,A,--46125727(+) ATATAC/TACACA 1 -- int10--------
    rs794123261,2
    		C,F,--49081787(+) TCCAAC/TGGACT 1 -- ds50014Minor allele frequency- T:0.11WA CSA 124
    rs755445201,2
    		F,--49081788(+) CCAACG/AGACTC 1 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1473647281,2
    		--49081903(+) TGGACA/GCGGTG 1 -- ds50010--------
    rs1394056721,2
    		--49081905(+) GACGCA/GGTGGC 1 -- ds50010--------
    rs1927250401,2
    		--49082101(+) GAACCC/TGGGAA 1 -- ds50010--------
    rs1453027751,2
    		--49082127(+) AGCCGA/GGATCA 1 -- ds50010--------
    rs347706861,2
    		C--49082178(+) GTCTC-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs602492121,2
    		C--49082179(+) AAAAAA/-GACTA 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1845087751,2
    		--49082228(+) ACATAA/GACAAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCNT1 (49082247 - 49110781 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCNT1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CCNT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCNT1 for disorders           About GeneDecksing

    OMIM gene information: 143055    OMIM disorders: --

    20/22 diseases for CCNT1 (see all 22):    About MalaCards
    immunodeficiency    diffuse large b-cell lymphoma    human immunodeficiency virus infectious disease    b-cell lymphomas
    cytomegalovirus infection    chronic lymphocytic leukemia    stomatitis    lymphocytic leukemia
    werner syndrome    leukemia    vaccinia    anemia
    lung adenocarcinoma    t-cell leukemia    nasopharyngitis    influenza
    adenocarcinoma    neuroblastoma    malaria    hiv type 1

    9 Novoseek disease relationships for CCNT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 74.4 51 15254183 (2), 12368300 (2), 16439541 (2), 11739686 (2) (see all 39)
    equine infectious anemia 74.2 2 17540406 (1), 10683321 (1)
    vesicular stomatitis 40.6 1 16713742 (1)
    leukemia 20.1 2 15096811 (1), 12727882 (1)
    hiv infections 12.8 4 19886831 (1), 16330531 (1)
    lymphoma b-cell 7.92 1 15258998 (1)
    tumors 2.72 7 15753651 (1), 19228744 (1), 14751090 (1)
    leukemia lymphocytic chronic 2.02 1 17325859 (1)
    lymphoma 0 3 15258998 (2), 17325859 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCNT1 (1 document)

    Export disorders for CCNT1 gene to outside databases

    Publications
    for CCNT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNT1 gene, integrated from 9 sources (see all 350):
    (articles sorted by number of sources associating them with CCNT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of multiple cyclin subunits of human P-TEFb. (PubMed id 9499409)1, 2, 3, 9 Peng J.-M.... Price D.H. (1998)
    2. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. (PubMed id 9491887)1, 2, 3, 9 Wei P.... Jones K.A. (1998)
    3. Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1. (PubMed id 14972556)1, 2, 9 Das C.... Frankel A.D. (2004)
    4. Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation. (PubMed id 10329125)1, 2, 9 Ivanov D....Gaynor R.B. (1999)
    5. The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription. (PubMed id 12944466)1, 2, 9 Young T.M.... Mathews M.B. (2003)
    6. Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter. (PubMed id 10913173)1, 2, 9 Fong Y.W. and Zhou Q. (2000)
    7. The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. (PubMed id 9832504)1, 2, 9 Garber M.E.... Jones K.A. (1998)
    8. Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation. (PubMed id 10329126)1, 2, 9 Kwak Y.T.... Gaynor R.B. (1999)
    9. Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. (PubMed id 10364329)1, 2, 9 Bieniasz P.D.... Cullen B.R. (1999)
    10. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1, 2 Jeronimo C.... Coulombe B. (2007)

    External Searches for CCNT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCNT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 904 HGNC: 1599 AceView: CCNT1 Ensembl:ENSG00000129315 euGenes: HUgn904
    ECgene: CCNT1 H-InvDB: CCNT1

    Other Databases showing CCNT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCNT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNT1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CCNT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCNT1 gene:
    Search GeneIP for patents involving CCNT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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