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Aliases for CCNT1 Gene

Aliases for CCNT1 Gene

  • Cyclin T1 2 3 5
  • Human Immunodeficiency Virus Type 1 (HIV-1) Expression (Elevated) 1 2 3
  • CYCT1 3 4
  • CDK9-Associated C-Type Protein 3
  • Cyclin C-Related Protein 3
  • Cyclin-T 4
  • HIVE1 3
  • CCNT 3

External Ids for CCNT1 Gene

Previous HGNC Symbols for CCNT1 Gene

  • HIVE1

Previous GeneCards Identifiers for CCNT1 Gene

  • GC12M049053
  • GC12M048803
  • GC12M047373
  • GC12M047372
  • GC12M049086
  • GC12M046120
  • GC12M049087
  • GC12M049093

Summaries for CCNT1 Gene

Entrez Gene Summary for CCNT1 Gene

  • This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

GeneCards Summary for CCNT1 Gene

CCNT1 (Cyclin T1) is a Protein Coding gene. Diseases associated with CCNT1 include hiv-1 and ipex syndrome. Among its related pathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. GO annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is CCNT2.

UniProtKB/Swiss-Prot for CCNT1 Gene

  • Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).

  • (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tats affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.

Gene Wiki entry for CCNT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNT1 Gene

Genomics for CCNT1 Gene

Regulatory Elements for CCNT1 Gene

Enhancers for CCNT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCNT1 on UCSC Golden Path with GeneCards custom track

Promoters for CCNT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNT1 Gene

Chromosome:
12
Start:
48,688,458 bp from pter
End:
48,716,998 bp from pter
Size:
28,541 bases
Orientation:
Minus strand

Genomic View for CCNT1 Gene

Genes around CCNT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNT1 Gene

Proteins for CCNT1 Gene

  • Protein details for CCNT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60563-CCNT1_HUMAN
    Recommended name:
    Cyclin-T1
    Protein Accession:
    O60563
    Secondary Accessions:
    • A9XU13
    • E7EX76
    • O60581

    Protein attributes for CCNT1 Gene

    Size:
    726 amino acids
    Molecular mass:
    80685 Da
    Quaternary structure:
    • Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with BRD4, probably to target chromatin binding. Interacts with MDFIC.
    • (Microbial infection) Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat.
    Miscellaneous:
    • Interaction between Tat and cyclin-T1 requires zinc.

    Three dimensional structures from OCA and Proteopedia for CCNT1 Gene

    Alternative splice isoforms for CCNT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNT1 Gene

Proteomics data for CCNT1 Gene at MOPED

Post-translational modifications for CCNT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNT1 Gene

No data available for DME Specific Peptides for CCNT1 Gene

Domains & Families for CCNT1 Gene

Gene Families for CCNT1 Gene

Protein Domains for CCNT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60563

UniProtKB/Swiss-Prot:

CCNT1_HUMAN :
  • Belongs to the cyclin family. Cyclin C subfamily.
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.
genes like me logo Genes that share domains with CCNT1: view

Function for CCNT1 Gene

Molecular function for CCNT1 Gene

GENATLAS Biochemistry:
cyclin T1,87kDa,associating with the transcription elongation factor CDK9,interacting with HIV-1Tat and mediating its high affinity to TAR
UniProtKB/Swiss-Prot Function:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tats affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.

Gene Ontology (GO) - Molecular Function for CCNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9499409
GO:0017069 snRNA binding IEA --
genes like me logo Genes that share ontologies with CCNT1: view
genes like me logo Genes that share phenotypes with CCNT1: view

Animal Model Products

miRNA for CCNT1 Gene

miRTarBase miRNAs that target CCNT1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNT1 Gene

Localization for CCNT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNT1 Gene COMPARTMENTS Subcellular localization image for CCNT1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CCNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CCNT1: view

Pathways & Interactions for CCNT1 Gene

genes like me logo Genes that share pathways with CCNT1: view

SIGNOR curated interactions for CCNT1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CCNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IPI 16109376
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process IEA,TAS --
genes like me logo Genes that share ontologies with CCNT1: view

Drugs & Compounds for CCNT1 Gene

(9) Drugs for CCNT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CCNT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNT1: view

Transcripts for CCNT1 Gene

mRNA/cDNA for CCNT1 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCNT1 Gene

Cyclin T1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNT1 Gene

No ASD Table

Relevant External Links for CCNT1 Gene

GeneLoc Exon Structure for
CCNT1
ECgene alternative splicing isoforms for
CCNT1

Expression for CCNT1 Gene

mRNA expression in normal human tissues for CCNT1 Gene

Protein differential expression in normal tissues from HIPED for CCNT1 Gene

This gene is overexpressed in Liver (38.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNT1 Gene



SOURCE GeneReport for Unigene cluster for CCNT1 Gene Hs.92308

mRNA Expression by UniProt/SwissProt for CCNT1 Gene

O60563-CCNT1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with CCNT1: view

Protein tissue co-expression partners for CCNT1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CCNT1 Gene

Orthologs for CCNT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNT1 35
  • 90.43 (n)
  • 88.97 (a)
CCNT1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNT1 35
  • 93.63 (n)
  • 93.63 (a)
CCNT1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnt1 35
  • 86.9 (n)
  • 89.79 (a)
Ccnt1 16
Ccnt1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNT1 35
  • 99.76 (n)
  • 99.72 (a)
CCNT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnt1 35
  • 83.85 (n)
  • 86.6 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNT1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNT1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNT1 35
  • 67.05 (n)
  • 68.77 (a)
CCNT1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNT1 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccnt1 35
  • 59.39 (n)
  • 62.56 (a)
Dr.18505 35
ccnt1 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5159 35
fruit fly
(Drosophila melanogaster)
Insecta CycT 37
  • 57 (a)
CycT 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cit-1.1 36
  • 25 (a)
ManyToMany
cit-1.2 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for CCNT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCNT1 Gene

ENSEMBL:
Gene Tree for CCNT1 (if available)
TreeFam:
Gene Tree for CCNT1 (if available)

Paralogs for CCNT1 Gene

Paralogs for CCNT1 Gene

(2) SIMAP similar genes for CCNT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCNT1: view

Variants for CCNT1 Gene

Sequence variations from dbSNP and Humsavar for CCNT1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17123261 - 48,694,129(+) AGGAA(C/T)GATCA reference, missense, utr-variant-3-prime
VAR_069400 -
rs3013 -- 48,693,873(+) CGCTC(A/C/G)GGGTT reference, synonymous-codon, utr-variant-3-prime
rs7134192 -- 48,713,177(+) TTCCT(A/C/G)TTCTT intron-variant
rs11534 -- 48,688,636(-) GTTAT(A/G)TGAAT utr-variant-3-prime

Variation tolerance for CCNT1 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNT1 Gene

HapMap Linkage Disequilibrium report
CCNT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCNT1 Gene

Disorders for CCNT1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCNT1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
ipex syndrome
  • immunodeficiency
- elite association - COSMIC cancer census association via MalaCards
Search CCNT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNT1

Genetic Association Database (GAD)
CCNT1
Human Genome Epidemiology (HuGE) Navigator
CCNT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNT1
genes like me logo Genes that share disorders with CCNT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNT1 Gene

Publications for CCNT1 Gene

  1. Identification of multiple cyclin subunits of human P-TEFb. (PMID: 9499409) Peng J.-M. … Price D.H. (Genes Dev. 1998) 2 3 4 23 67
  2. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. (PMID: 9491887) Wei P. … Jones K.A. (Cell 1998) 2 3 23
  3. Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters. (PMID: 20054825) Hoque M. … Pe'ery T. (J. Cell. Physiol. 2010) 3 23
  4. A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1. (PMID: 20210365) SchAPnichen A. … Geyer M. (Biochemistry 2010) 3 23
  5. Transcriptional restriction of human immunodeficiency virus type 1 gene expression in undifferentiated primary monocytes. (PMID: 19211771) Dong C. … Wu L. (J. Virol. 2009) 3 23

Products for CCNT1 Gene

Sources for CCNT1 Gene

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