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CCNO Gene

protein-coding   GIFtS: 54
GCID: GC05M054526

Cyclin O

(Previous name: cyclin U)
(Previous symbol: CCNU)
  See CCNO-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin O1 2     Cyclin Domain Containing2
CCNU1 2     cyclin-O2
Cyclin U1 2     UNG25
UDG22     

External Ids:    HGNC: 185761   Entrez Gene: 103092   Ensembl: ENSG000001526697   OMIM: 6077525   UniProtKB: P226743   

Export aliases for CCNO gene to outside databases

Previous GC identifers: GC05M054564 GC05M054565 GC05M051499


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNO Gene:
This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed
ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family
member. The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so
confusion exists in the scientific literature and in some databases for these two genes.(provided by RefSeq, Nov
2010)

GeneCards Summary for CCNO Gene:
CCNO (cyclin O) is a protein-coding gene. Diseases associated with CCNO include ciliary diskinesia, primary, 29, and ciliary dyskinesia, primary, 19. GO annotations related to this gene include protein kinase binding and uracil DNA N-glycosylase activity. An important paralog of this gene is CCNE1.

Gene Wiki entry for CCNO (Cyclin O) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNO gene promoter:
         NF-1   Pax-6   CUTL1   Tal-1beta   Arnt   GATA-1   Pax-3   CP2   ZIC2/Zic2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNO promoter sequence
   Search Chromatin IP Primers for CCNO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

CCNO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNO gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M054526:  view genomic region     (about GC identifiers)

Start:
54,526,980 bp from pter      End:
54,529,508 bp from pter
Size:
2,529 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCNO_HUMAN, P22674 (See protein sequence)
Recommended Name: Cyclin-O  
Size: 350 amino acids; 38096 Da
Developmental stage: Maximum levels during G(1) phase. Levels decrease through S and G(2) phases
Caution: Was originally thought to have uracil-DNA glycosylase (UDG) activity and wrongly named UNG2 and UDG2
(PubMed:2001396). It was later shown that it is a member of the cyclin family (PubMed:8419333). UNG2 corresponds
to the isoform 2 of UNG gene
Sequence caution: Sequence=AAB05817.1; Type=Miscellaneous discrepancy; Note=Sequencing errors;
Sequence=CAA36728.1; Type=Miscellaneous discrepancy; Note=Sequencing errors;
Secondary accessions: A8K1W5 Q0P6J2 Q9H6B0 Q9UMD5
Alternative splicing: 2 isoforms:  P22674-1   P22674-2   

Explore the universe of human proteins at neXtProt for CCNO: NX_P22674

Explore proteomics data for CCNO at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCNO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066970.3  
    ENSEMBL proteins: 
     ENSP00000422485   ENSP00000282572  
    Reactome Protein details: P22674

    CCNO Human Recombinant Protein Products:

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    Novus Biologicals CCNO Lysate
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for CCNO

     
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    CCNO Assay Products:

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    Search eBioscience for ELISAs for CCNO 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028864 Ccno
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P22674

    ProtoNet protein and cluster: P22674

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNO_HUMAN, P22674
    Similarity: Belongs to the cyclin family


    Find genes that share domains with CCNO           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004844uracil DNA N-glycosylase activity IDA12161446
    GO:0019901protein kinase binding IEA--
         
    Find genes that share ontologies with CCNO           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNO
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCNO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNO

    miRNA
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    miRTarBase miRNAs that target CCNO:
    hsa-mir-192-5p (MIRT026829), hsa-mir-215-5p (MIRT024544)

    Block miRNA regulation of human, mouse, rat CCNO using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCNO
    SwitchGear 3'UTR luciferase reporter plasmidCCNO 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCNO
    Predesigned siRNA for gene silencing in human, mouse, rat CCNO

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CCNO (NM_021147)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNO

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with CCNO           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNO About    
    See pathways by source

    SuperPathContained pathways About
    1Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Base Excision Repair0.00
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    Displacement of DNA glycosylase by APE10.00
    Base-Excision Repair, AP Site Formation0.00
    Resolution of AP sites via the single-nucleotide replacement pathway0.00
    Base-free sugar-phosphate removal via the single-nucleotide replacement pathway0.00
    Removal of DNA patch containing abasic residue0.00
    2Cleavage of the damaged pyrimidine
    Cleavage of the damaged pyrimidine
    Depyrimidination0.00
    Recognition and association of DNA glycosylase with site containing an affected pyrimidine0.00
    3DNA Repair
    DNA Repair0.45


    Find genes that share SuperPaths with CCNO           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CCNO
        DNA Repair Mechanisms

    3 Reactome Pathways for CCNO
        Recognition and association of DNA glycosylase with site containing an affected pyrimidine
    Displacement of DNA glycosylase by APE1
    Cleavage of the damaged pyrimidine


        Pathway & Disease-focused RT2 Profiler PCR Array including CCNO: 
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNO (P226742, 3 ENSP000002825724) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC1P188872, 3, ENSP000002628874MINT-7294888 MINT-7294905 I2D: score=1 STRING: ENSP00000262887
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    ITSN1Q158113, ENSP000003707194I2D: score=1 STRING: ENSP00000370719
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    RPA2P159273, ENSP000003630214I2D: score=2 STRING: ENSP00000363021
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    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0006281DNA repair TAS--
    GO:0006284base-excision repair TAS--
    GO:0006285base-excision repair, AP site formation TAS--
    GO:0007049cell cycle IDA8419333

    Find genes that share ontologies with CCNO           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNO

    2 Novoseek inferred chemical compound relationships for CCNO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytosine 67.7 5 17537817 (2), 17272283 (1), 17101234 (1)
    cytidine 58 1 19023113 (1)



    Find genes that share compounds with CCNO           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNO gene (2 alternative transcripts): 
    NM_001024592.1  NM_021147.3  

    Unigene Cluster for CCNO:

    Cyclin O
    Hs.3041  [show with all ESTs]
    Unigene Representative Sequence: BC004877
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000501463(uc003jpv.3) ENST00000282572(uc003jpw.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat CCNO using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CCNO
    SwitchGear 3'UTR luciferase reporter plasmidCCNO 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCNO
    Predesigned siRNA for gene silencing in human, mouse, rat CCNO
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCNO (NM_021147)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNO
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCNO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNO
      QuantiTect SYBR Green Assays in human, mouse, rat CCNO
      QuantiFast Probe-based Assays in human, mouse, rat CCNO

    Additional mRNA sequence: 

    AK026075.1 AK290030.1 BC004877.2 BC056254.1 BC143905.1 BC143907.1 

    5 DOTS entries:

    DT.411602  DT.120864645  DT.75102448  DT.92022702  DT.95164971 

    Selected AceView cDNA sequences (see all 66):

    AI769828 BU633834 AK026075 BC004877 CB132051 BE139607 BM760216 BC056254 
    BM845204 BC017345 AI590103 BU178239 AW514938 CA450228 BM982180 AI570443 
    AI536831 AW167684 AW246439 BU609132 AW137498 BI259616 BM754944 AI949695 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CCNO    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
    SP1:        -     -     -                           
    SP2:                                                
    SP3:                    -                           
    SP4:                                                


    ECgene alternative splicing isoforms for CCNO

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAGCTGA
    CCNO Expression
    About this image


    CCNO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             Dorsal forebrain-like neurons
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Neurons
             Dorsal forebrain-like neurons
     
     Neural Tube (Nervous System)
             Diencephalic Roof Plate
    CCNO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.3041
        Pathway & Disease-focused RT2 Profiler PCR Array including CCNO: 
              DNA Repair in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCNO gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccno1 , 5 cyclin O1, 5 81.52(n)1
    80.57(a)1
      13 (63.93 cM)5
    2186301  NM_001081062.11  NP_001074531.11 
     1129878025 
    chicken
    (Gallus gallus)
    Aves CCNO1 cyclin O 75.03(n)
    69.32(a)
      100857393  XM_003642984.2  XP_003643032.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNO6
    cyclin O
    59(a)
    1 ↔ 1
    2(2606877-2612448)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.339422 Xenopus laevis transcribed sequences 74.88(n)    BJ627795.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018834901 cyclin-O-like 57.89(n)
    53.07(a)
      101883490  XM_005168655.1  XP_005168712.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycD6
    Cyclin D
    12(a)
    1 → many
    X(15800855-15803709)


    ENSEMBL Gene Tree for CCNO (if available)
    TreeFam Gene Tree for CCNO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNO gene
    CCNE12  CCND32  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  

    Find genes that share paralogs with CCNO           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNO (see all 149)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380267211,2
    --51504521(+) TTTTTC/GAGACA 1 -- us2k10--------
    rs744966761,2
    F--54526593(+) CAATGG/TCTGTG 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1898356011,2
    --54526629(+) ACATGC/TTCCAT 1 -- int10--------
    rs1925418251,2
    --54526662(+) CTGGAA/TATGGC 1 -- int10--------
    rs797649711,2
    C,F--54526697(+) CTGTGT/GGGTCC 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1849288881,2
    --54526729(+) TCTGCC/TTCACC 1 -- int10--------
    rs762961751,2
    C,F--54526980(+) CAGGAT/CTTAGA 1 -- ut311Minor allele frequency- C:0.02NA 120
    rs1898620851,2
    --54527001(+) CTGTTA/TATTGG 1 -- ut310--------
    rs1159639441,2
    C,F--54527064(+) TGCTAG/ATATCG 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1148473121,2
    C,F--54527151(+) GCTACG/CGGAGA 1 -- ut311Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for CCNO (54526980 - 54529508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCNO:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6070n71CNV Loss21882294
    nsv830302CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNO
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607752    OMIM disorders: --

    2 diseases for CCNO:    
    About MalaCards
    ciliary diskinesia, primary, 29    ciliary dyskinesia, primary, 19


    Find genes that share disorders with CCNO           About GenesLikeMe

    2 Novoseek inferred disease relationships for CCNO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 29.5 1 17062624 (1)
    immunodeficiency 26.6 3 17062624 (1), 17272283 (1)

    Genetic Association Database (GAD): CCNO
    Human Genome Epidemiology (HuGE) Navigator: CCNO (1 document)

    Export disorders for CCNO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNO gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with CCNO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. (PubMed id 8419333)1, 2 Muller S.J. and Caradonna S. (J. Biol. Chem. 1993)
    5. Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. (PubMed id 2001396)1, 2 Muller S.J. and Caradonna S. (Biochim. Biophys. Acta 1991)
    6. The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues. (PubMed id 16697536)2, 9 Hirst R.... Miller D. (Gene 2006)
    7. The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection. (PubMed id 23849790)1 Casey Klockow L....de Noronha C.M. (Virology 2013)
    8. The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover. (PubMed id 22292079)1 Wen X....de Noronha C.M. (PLoS ONE 2012)
    9. Uracil DNA N-glycosylase promotes assembly of human centromere protein A. (PubMed id 21399697)1 Zeitlin S.G....Wang J.Y. (PLoS ONE 2011)
    10. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10309 HGNC: 18576 AceView: UNG2 Ensembl:ENSG00000152669 euGenes: HUgn10309
    ECgene: CCNO H-InvDB: CCNO

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNO gene:
    Search GeneIP for patents involving CCNO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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