Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCNO Gene

Aliases for CCNO Gene

  • Cyclin O 2 3
  • Cyclin U 2 3
  • Cyclin Domain Containing 3
  • CILD29 3
  • UDG2 3
  • CCNU 3

External Ids for CCNO Gene

Previous HGNC Symbols for CCNO Gene

  • CCNU

Previous GeneCards Identifiers for CCNO Gene

  • GC05M054564
  • GC05M054565
  • GC05M054526
  • GC05M051499

Summaries for CCNO Gene

Entrez Gene Summary for CCNO Gene

  • This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

GeneCards Summary for CCNO Gene

CCNO (Cyclin O) is a Protein Coding gene. Diseases associated with CCNO include primary ciliary dyskinesia29: ccno-related primary ciliary dyskinesia and ciliary dyskinesia, primary, 29. GO annotations related to this gene include protein kinase binding and uracil DNA N-glycosylase activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNO Gene

  • Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.

Gene Wiki entry for CCNO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNO Gene

Genomics for CCNO Gene

Regulatory Elements for CCNO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNO Gene

Chromosome:
5
Start:
55,231,152 bp from pter
End:
55,233,717 bp from pter
Size:
2,566 bases
Orientation:
Minus strand

Genomic View for CCNO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNO Gene

Proteins for CCNO Gene

  • Protein details for CCNO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22674-CCNO_HUMAN
    Recommended name:
    Cyclin-O
    Protein Accession:
    P22674
    Secondary Accessions:
    • A8K1W5
    • Q0P6J2
    • Q9H6B0
    • Q9UMD5

    Protein attributes for CCNO Gene

    Size:
    350 amino acids
    Molecular mass:
    38096 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB05817.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=CAA36728.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNO Gene

Proteomics data for CCNO Gene at MOPED

Post-translational modifications for CCNO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNO Gene

Domains & Families for CCNO Gene

Gene Families for CCNO Gene

Protein Domains for CCNO Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22674

UniProtKB/Swiss-Prot:

CCNO_HUMAN :
  • Belongs to the cyclin family.
Family:
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNO: view

Function for CCNO Gene

Molecular function for CCNO Gene

UniProtKB/Swiss-Prot Function:
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.

Gene Ontology (GO) - Molecular Function for CCNO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004844 uracil DNA N-glycosylase activity IDA 12161446
genes like me logo Genes that share ontologies with CCNO: view

Phenotypes for CCNO Gene

GenomeRNAi human phenotypes for CCNO:
genes like me logo Genes that share phenotypes with CCNO: view

miRNA for CCNO Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNO

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNO Gene

Localization for CCNO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNO Gene

Cytoplasm. Note=Localizes to the apical part of cytoplasm. {ECO:0000269 PubMed:24747639}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNO Gene COMPARTMENTS Subcellular localization image for CCNO gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for CCNO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA 12161446
GO:0005737 cytoplasm IDA 24747639
genes like me logo Genes that share ontologies with CCNO: view

Pathways & Interactions for CCNO Gene

SuperPathways for CCNO Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CCNO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006284 base-excision repair IDA 12161446
GO:0007049 cell cycle IDA 8419333
GO:0042384 cilium assembly IMP 24747639
GO:0042493 response to drug IEA --
GO:0051301 cell division IDA 8419333
genes like me logo Genes that share ontologies with CCNO: view

No data available for Pathways by source and SIGNOR curated interactions for CCNO Gene

Drugs & Compounds for CCNO Gene

(1) Drugs for CCNO Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine Experimental Pharma 0

(1) Additional Compounds for CCNO Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cytosine
  • 4-Amino-2(1H)-pyrimidinone
  • 4-Amino-2-hydroxypyrimidine
  • 4-Amino-2-oxo-1,2-dihydropyrimidine
  • 4-Aminouracil
  • Cytosine
71-30-7
genes like me logo Genes that share compounds with CCNO: view

Transcripts for CCNO Gene

mRNA/cDNA for CCNO Gene

Unigene Clusters for CCNO Gene

Cyclin O:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNO Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2:
SP3: -
SP4:

Relevant External Links for CCNO Gene

GeneLoc Exon Structure for
CCNO
ECgene alternative splicing isoforms for
CCNO

Expression for CCNO Gene

mRNA expression in normal human tissues for CCNO Gene

mRNA differential expression in normal tissues according to GTEx for CCNO Gene

This gene is overexpressed in Pancreas (x5.1) and Testis (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNO Gene



SOURCE GeneReport for Unigene cluster for CCNO Gene Hs.3041

mRNA Expression by UniProt/SwissProt for CCNO Gene

P22674-CCNO_HUMAN
Tissue specificity: Present in respiratory cells (at protein level).
genes like me logo Genes that share expression patterns with CCNO: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for CCNO Gene

Orthologs for CCNO Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNO 35
  • 87.84 (n)
  • 88.22 (a)
CCNO 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNO 35
  • 88.38 (n)
  • 90.29 (a)
CCNO 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccno 35
  • 81.52 (n)
  • 80.57 (a)
Ccno 16
Ccno 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNO 35
  • 99.43 (n)
  • 98.86 (a)
CCNO 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccno 35
  • 80.74 (n)
  • 81.17 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNO 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNO 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNO 35
  • 75.03 (n)
  • 69.32 (a)
CCNO 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNO 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccno 35
  • 60.73 (n)
  • 57.76 (a)
Str.1266 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33942 35
zebrafish
(Danio rerio)
Actinopterygii LOC101883490 35
  • 57.89 (n)
  • 53.07 (a)
ccnd3 36
  • 21 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CycD 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for CCNO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNO Gene

ENSEMBL:
Gene Tree for CCNO (if available)
TreeFam:
Gene Tree for CCNO (if available)

Paralogs for CCNO Gene

Paralogs for CCNO Gene

genes like me logo Genes that share paralogs with CCNO: view

Variants for CCNO Gene

Sequence variations from dbSNP and Humsavar for CCNO Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_029081 -
VAR_071197 Ciliary dyskinesia, primary, 29 (CILD29)

Structural Variations from Database of Genomic Variants (DGV) for CCNO Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV Gain 17160897
dgv6070n71 CNV Loss 21882294

Variation tolerance for CCNO Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNO Gene

HapMap Linkage Disequilibrium report
CCNO
Human Gene Mutation Database (HGMD)
CCNO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNO Gene

Disorders for CCNO Gene

MalaCards: The human disease database

(7) MalaCards diseases for CCNO Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
primary ciliary dyskinesia29: ccno-related primary ciliary dyskinesia
  • ciliary dyskinesia, primary, 29
ciliary dyskinesia, primary, 29
  • primary ciliary dyskinesia without situs inversus
mucociliary clearance disorder
ciliary dyskinesia, primary, 1, with or without situs inversus
  • kartagener syndrome
bronchiectasis
  • kartagener syndrome
- elite association
Search CCNO in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CCNO_HUMAN
  • Ciliary dyskinesia, primary, 29 (CILD29) [MIM:615872]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD29 patients do not exhibit situs inversus, a congenital abnormality in which visceral organs are opposite to their normal positions (situs solitus) due to lateral transposition. {ECO:0000269 PubMed:24747639}. Note=The disease is caused by mutations affecting the gene represented in this entry. Marked reduction of cilia in multiciliate cells due to defective mother centriole generation and placement. Remaining cilia correctly express axonemal motor proteins, are motile and do not show beating defects. Defects are probably caused by a strong reduction in the number of multiple motile cilia covering the cell surface in respiratory epithelial cells (PubMed:24747639). {ECO:0000269 PubMed:24747639}.

Relevant External Links for CCNO

Genetic Association Database (GAD)
CCNO
Human Genome Epidemiology (HuGE) Navigator
CCNO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNO
genes like me logo Genes that share disorders with CCNO: view

No data available for Genatlas for CCNO Gene

Publications for CCNO Gene

  1. Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression. (PMID: 19411194) Aas P.A. … Skorpen F. (DNA Repair (Amst.) 2009) 23 67
  2. Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting. (PMID: 19023113) Longo N.S. … Lipsky P.E. (Blood 2009) 23 67
  3. Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil. (PMID: 19402749) Kunz C. … SchAor P. (PLoS Biol. 2009) 23 67
  4. Uracil DNA Glycosylase 2 negatively regulates HIV-1 LTR transcription. (PMID: 19696076) Fenard D. … Briant L. (Nucleic Acids Res. 2009) 23 67
  5. Physical and functional interactions between uracil-DNA glycosylase and proliferating cell nuclear antigen from the euryarchaeon Pyrococcus furiosus. (PMID: 18562313) Kiyonari S. … Ishino Y. (J. Biol. Chem. 2008) 23 67

Products for CCNO Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCNO
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCNO
    • Block miRNA regulation of CCNO using miScript Target Protectors

    Sources for CCNO Gene

    Back to Top

    Content