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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCNO Gene

protein-coding GIFtS: 53
GCID: GC05M054526

cyclin O

(Previous name: cyclin U )
(Previous symbol: CCNU)

Explore 4 diseases affiliated with
CCNO via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin O¹ ²		UNG2¹ ⁵
CCNU¹ ²		FLJ22422¹
UDG2¹ ²		Cyclin Domain Containing²
Cyclin U¹ ²		Cyclin-O¹

External Ids:	HGNC: 18576¹	Entrez Gene: 10309²	Ensembl: ENSG00000152669⁷	OMIM: 607752⁵	UniProtKB: P22674³

Export aliases for CCNO gene to outside databases

Previous GC identifers: GC05M054564 GC05M054565 GC05M051499

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNO:

This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID:

2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member.

The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in

the scientific literature and in some databases for these two genes.(provided by RefSeq, Nov 2010)

Gene Wiki entry for CCNO (Cyclin O)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNO gene promoter:
NF-1 Pax-6 CUTL1 Tal-1beta Arnt GATA-1 Pax-3 CP2 ZIC2/Zic2 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNO promoter sequence

Search SABiosciences Chromatin IP Primers for CCNO

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNO

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2

CCNO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNO gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M054526: view genomic region (about GC identifiers)

Start:	54,526,980 bp from pter	End:	54,529,508 bp from pter
Size:	2,529 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCNO_HUMAN, P22674 (See protein sequence)

Recommended Name: Cyclin-O

Size: 350 amino acids; 38096 Da

Developmental stage: Maximum levels during G(1) phase. Levels decrease through S and G(2) phases

Caution: Was originally thought to have uracil-DNA glycosylase (UDG) activity and wrongly named UNG2 and UDG2

(PubMed:2001396). It was later shown that it is a member of the cyclin family (PubMed:8419333). UNG2 corresponds to

the isoform 2 of UNG gene

Sequence caution: Sequence=AAB05817.1; Type=Miscellaneous discrepancy; Note=Sequencing errors; Sequence=CAA36728.1;

Type=Miscellaneous discrepancy; Note=Sequencing errors;

Secondary accessions: A8K1W5 Q0P6J2 Q9H6B0 Q9UMD5

Alternative splicing: 2 isoforms: P22674-1 P22674-2

Explore the universe of human proteins at neXtProt for CCNO: NX_P22674

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P22674

CCNO Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_066970.3

ENSEMBL proteins:

ENSP00000282572 ENSP00000422485

Reactome Protein details: P22674
Human Recombinant Protein Products:

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	Novus Biologicals CCNO Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CCNO

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--

CCNO for ontologies About GeneDecksing

CCNO Antibody Products:

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	OriGene Antibodies (see all 2): CCNO OriGene Custom Antibody Services for CCNO
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	Novus Biologicals CCNO Antibodies
	Search for Antibodies for CCNO at Abcam
	Uscn Antibodies for CCNO
	ThermoFisher Antibodies for CCNO

Assay Products for CCNO:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for CCNO
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCNO

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCNO for domains About GeneDecksing

4 InterPro domains/families:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR004367 Cyclin_C

IPR014400 Cyclin_A/B/D/E

Graphical View of Domain Structure for InterPro Entry P22674

ProtoNet protein and cluster: P22674

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNO_HUMAN, P22674

Similarity: Belongs to the cyclin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone: CCNO Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNO
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCNO
		SwitchGear 3'UTR luciferase reporter plasmid: CCNO 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNO (see all 7) OriGene shRNA RFP: CCNO OriGene siRNA: CCNO
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNO

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCNO

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNO (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNO OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCNO (NM_021147)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNO
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNO

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCNO
		Search LifeMap BioReagents cell lines for CCNO

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNO

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004844	uracil DNA N-glycosylase activity	IDA	12161446
GO:0019901	protein kinase binding	IEA	--

CCNO for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Base-Excision Repair, AP Site Formation

Base-Excision Repair, AP Site Formation	1.00	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	0.62
Displacement of DNA glycosylase by APE1	0.89	Cleavage of the damaged pyrimidine	0.62
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway	0.80	Depyrimidination	0.62
Resolution of AP sites via the single-nucleotide replacement pathway	0.67

Resolution of Abasic Sites (AP sites)

	Base Excision Repair	1.00			Removal of DNA patch containing abasic residue	0.89
	Resolution of Abasic Sites (AP sites)	1.00			Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.89

Nucleotide Excision Repair

DNA Repair

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

5/12 Reactome Pathways for CCNO (see all 12)

	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
	Removal of DNA patch containing abasic residue
	DNA Repair
	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
	Base-Excision Repair, AP Site Formation

CCNO for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNO

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/8 Interacting proteins for CCNO (P22674^{2, 3} ENSP00000282572⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XRCC1	P18887²^,³, ENSP00000262887⁴	MINT-7294888 MINT-7294905 I2D: score=1 STRING: ENSP00000262887
PCNA	P12004³, ENSP00000368438⁴	I2D: score=2 STRING: ENSP00000368438
ITSN1	Q15811³, ENSP00000370719⁴	I2D: score=1 STRING: ENSP00000370719
VAV2	P52735³, ENSP00000360916⁴	I2D: score=1 STRING: ENSP00000360916
RPA2	P15927³, ENSP00000363021⁴	I2D: score=2 STRING: ENSP00000363021

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	IEA	--
GO:0006281	DNA repair	TAS	--
GO:0006284	base-excision repair	TAS	--
GO:0006285	base-excision repair, AP site formation	TAS	--
GO:0007049	cell cycle	IDA	8419333

CCNO for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCNO for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCNO
2 Novoseek chemical compound relationships for CCNO gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cytosine	67.7	5	17537817 (2), 17272283 (1), 17101234 (1)
cytidine	58	1	19023113 (1)

Search CenterWatch for drugs/clinical trials and news about CCNO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCNO gene (2 alternative transcripts):

NM_001024592.1 NM_021147.3

Unigene Cluster for CCNO:

Cyclin O

Hs.3041 [show with all ESTs]

Unigene Representative Sequence: BC004877

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000282572(uc003jpw.3) ENST00000501463(uc003jpv.3)

miRNA Products:		OriGene 3'-UTR Clone: CCNO Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNO
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCNO
		SwitchGear 3'UTR luciferase reporter plasmid: CCNO 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNO (see all 7) OriGene shRNA RFP: CCNO OriGene siRNA: CCNO
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNO

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNO (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNO OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCNO (NM_021147)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNO
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNO

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNO Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCNO
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNO
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNO

Additional cDNA sequence:

AK026075.1 AK290030.1 BC004877.2 BC056254.1 BC143905.1 BC143907.1

5 DOTS entries:

DT.411602 DT.120864645 DT.75102448 DT.92022702 DT.95164971

24/66 AceView cDNA sequences (see all 66):

BU178239 CB132051 BC004877 AI769828 AI590103 AK026075 BE139607 AW514938

BM845204 BC056254 BU633834 BC017345 BM760216 CA450228 BI259616 BF879293

AI769465 BM744194 BI828887 CB142389 AW167684 BI118165 BU609132 CA422370

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CCNO About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c
SP1:			-		-		-
SP2:
SP3:							-
SP4:

ECgene alternative splicing isoforms for CCNO

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCNO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAAGCTGA

About this image

CCNO expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Diencephalic Roof Plate

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

Secondary follicles (Primary Cell)

Ovary, Reproductive System

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

See CCNO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNO

SOURCE GeneReport for Unigene cluster: Hs.3041

SABiosciences Expression via Pathway-Focused PCR Array including CCNO:

DNA Repair in human mouse rat

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCNO
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNO

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNO

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCNO gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccno^{1 , 5}	cyclin O^{1, 5}	81.61(n)¹ 81.03(a)¹		13 (63.93 cM)⁵ 218630¹ NM_001081062.1¹ NP_001074531.1¹ 112987802⁵
chicken (Gallus gallus)	Aves	LOC100857393¹	cyclin-O-like	73.9(n) 67.83(a)		100857393 XM_003642984.1 XP_003643032.1
lizard (Anolis carolinensis)	Reptilia	CCNO⁶	--	65(a)	1 ↔ 1	2(2607250-2612036)
African clawed frog (Xenopus laevis)	Amphibia	Xl.33942²	Xenopus laevis transcribed sequences	74.88(n)		BJ627795.1

ENSEMBL Gene Tree for CCNO (if available)
TreeFam Gene Tree for CCNO (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCNO gene

CCND3² CCNE1² CCNB2² CCNE2² CCNB3² CCNB1² CCND1² CCNA1²

CCND2² CCNA2²

CCNO for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74496676^1,2	F,	--	54526593(+)	`CAATGG/TCTGTG`	1	--	int¹		1		EA	120
rs189835601^1,2		--	54526629(+)	`ACATGC/TTCCAT`	1	--	int¹		0	--	--	--	--
rs192541825^1,2		--	54526662(+)	`CTGGAA/TATGGC`	1	--	int¹		0	--	--	--	--
rs79764971^1,2	C,	--	54526697(+)	`CTGTGT/GGGTCC`	1	--	int¹		1		WA	118
rs184928888^1,2		--	54526729(+)	`TCTGCC/TTCACC`	1	--	int¹		0	--	--	--	--
rs76296175^1,2	F,	--	54526980(+)	`CAGGAT/CTTAGA`	1	--	ut3¹		1		NA	120
rs189862085^1,2		--	54527001(+)	`CTGTTA/TATTGG`	1	--	ut3¹		0	--	--	--	--
rs115963944^1,2		--	54527064(+)	`TGCTAG/ATATCG`	1	--	ut3¹		1		WA	118
rs114847312^1,2	F,	--	54527151(+)	`GCTACG/CGGAGA`	1	--	ut3¹		1		WA	118
rs199894225^1,2		--	54527163(+)	`GTCCAA/GCAGCC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCNO (54526980 - 54529508 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNO: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNO

DNA2.0 Custom Variant and Variant Library Synthesis for CCNO

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCNO for disorders           About GeneDecksing

OMIM gene information: 607752    OMIM disorders: --

4 diseases for CCNO:    About MalaCards

herpes simplex immunodeficiency pancreatic cancer pancreatitis

2 Novoseek disease relationships for CCNO gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma b-cell	29.5	1	17062624 (1)
immunodeficiency	26.6	3	17062624 (1), 17272283 (1)

Human Genome Epidemiology (HuGE) Navigator: CCNO (1 document)

Export disorders for CCNO gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCNO gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with CCNO)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)^{1, 2} Schmutz J.... Rubin E.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. (PubMed id 8419333)^{1, 2} Muller S.J. and Caradonna S. (1993)
Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. (PubMed id 2001396)^{1, 2} Muller S.J. and Caradonna S. (1991)
The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues. (PubMed id 16697536)^{2, 9} Hirst R.... Miller D. (2006)
The HIV1 protein Vpr acts to enhance constitutive DCAF 1-dependent UNG2 turnover. (PubMed id 22292079)¹ Wen X....de Noronha C.M. (2012)
Uracil DNA N-glycosylase promotes assembly of human c entromere protein A. (PubMed id 21399697)¹ Zeitlin S.G....Wang J.Y. (2011)
The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 comple x dimerizes via a short helical region in DCAF1. (PubMed id 21226479)¹ Ahn J....Gronenborn A.M. (2011)
HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for pro teasome-dependent degradation. (PubMed id 20870715)¹ Ahn J....Gronenborn A.M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10309	HGNC: 18576	AceView: UNG2	Ensembl:ENSG00000152669	euGenes: HUgn10309
ECgene: CCNO	H-InvDB: CCNO

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCNO	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CCNO gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCNO gene:
Search GeneIP for patents involving CCNO

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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