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Aliases for CCNO Gene

Aliases for CCNO Gene

  • Cyclin O 2 3
  • Cyclin U 2 3
  • Cyclin Domain Containing 3
  • Cyclin-O 3
  • CILD29 3
  • UDG2 3
  • CCNU 3
  • UNG2 6

External Ids for CCNO Gene

Previous Symbols for CCNO Gene

  • CCNU

Summaries for CCNO Gene

Entrez Gene Summary for CCNO Gene

  • This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

GeneCards Summary for CCNO Gene

CCNO (Cyclin O) is a Protein Coding gene. Diseases associated with CCNO include ciliary diskinesia, primary, 29 and hiv-1. Among its related pathways are Chks in Checkpoint Regulation and DNA Repair. GO annotations related to this gene include protein kinase binding and uracil DNA N-glycosylase activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNO Gene

  • Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.

Gene Wiki entry for CCNO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNO Gene

Genomics for CCNO Gene

Genomic Location for CCNO Gene

Start:
55,231,152 bp from pter
End:
55,233,680 bp from pter
Size:
2,529 bases
Orientation:
Minus strand

Genomic View for CCNO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNO Gene

Regulatory Elements for CCNO Gene

Proteins for CCNO Gene

  • Protein details for CCNO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22674-CCNO_HUMAN
    Recommended name:
    Cyclin-O
    Protein Accession:
    P22674
    Secondary Accessions:
    • A8K1W5
    • Q0P6J2
    • Q9H6B0
    • Q9UMD5

    Protein attributes for CCNO Gene

    Size:
    350 amino acids
    Molecular mass:
    38096 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB05817.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=CAA36728.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNO Gene

Proteomics data for CCNO Gene at MOPED

Post-translational modifications for CCNO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNO Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNO Gene

Domains for CCNO Gene

Protein Domains for CCNO Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22674

UniProtKB/Swiss-Prot:

CCNO_HUMAN
Family:
  • Belongs to the cyclin family.:
    • P22674
genes like me logo Genes that share domains with CCNO: view

No data available for Gene Families for CCNO Gene

Function for CCNO Gene

Molecular function for CCNO Gene

UniProtKB/Swiss-Prot Function: Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.

Gene Ontology (GO) - Molecular Function for CCNO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004844 uracil DNA N-glycosylase activity IDA 12161446
GO:0019901 protein kinase binding --
genes like me logo Genes that share ontologies with CCNO: view

miRNA for CCNO Gene

miRTarBase miRNAs that target CCNO

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCNO Gene

Localization for CCNO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNO Gene

Cytoplasm. Note=Localizes to the apical part of cytoplasm. {ECO:0000269 PubMed:24747639}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNO Gene COMPARTMENTS Subcellular localization image for CCNO gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCNO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA 12161446
GO:0005737 cytoplasm IDA 24747639
genes like me logo Genes that share ontologies with CCNO: view

Pathways for CCNO Gene

genes like me logo Genes that share pathways with CCNO: view

Gene Ontology (GO) - Biological Process for CCNO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0006281 DNA repair --
GO:0006284 base-excision repair IDA 12161446
GO:0006285 base-excision repair, AP site formation --
GO:0007049 cell cycle IDA 8419333
genes like me logo Genes that share ontologies with CCNO: view

Compounds for CCNO Gene

(2) Novoseek inferred chemical compound relationships for CCNO Gene

Compound -log(P) Hits PubMed IDs
cytosine 67.7 4
cytidine 58 1
genes like me logo Genes that share compounds with CCNO: view

Transcripts for CCNO Gene

mRNA/cDNA for CCNO Gene

Unigene Clusters for CCNO Gene

Cyclin O:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNO Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2:
SP3: -
SP4:

Relevant External Links for CCNO Gene

GeneLoc Exon Structure for
CCNO
ECgene alternative splicing isoforms for
CCNO

Expression for CCNO Gene

mRNA expression in normal human tissues for CCNO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNO Gene

This gene is overexpressed in Pancreas (5.1) and Testis (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCNO Gene

SOURCE GeneReport for Unigene cluster for CCNO Gene Hs.3041

mRNA Expression by UniProt/SwissProt for CCNO Gene

P22674-CCNO_HUMAN
Tissue specificity: Present in respiratory cells (at protein level).
genes like me logo Genes that share expressions with CCNO: view

Orthologs for CCNO Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNO 35
  • 99.43 (n)
  • 98.86 (a)
CCNO 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNO 35
  • 87.84 (n)
  • 88.22 (a)
CCNO 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNO 35
  • 88.38 (n)
  • 90.29 (a)
CCNO 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccno 35
  • 81.52 (n)
  • 80.57 (a)
Ccno 16
Ccno 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNO 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNO 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccno 35
  • 80.74 (n)
  • 81.17 (a)
chicken
(Gallus gallus)
Aves CCNO 35
  • 75.03 (n)
  • 69.32 (a)
CCNO 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNO 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33942 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccno 35
  • 60.73 (n)
  • 57.76 (a)
Str.1266 35
zebrafish
(Danio rerio)
Actinopterygii ccnd3 36
  • 21 (a)
ManyToMany
LOC101883490 35
  • 57.89 (n)
  • 53.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycD 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for CCNO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNO Gene

ENSEMBL:
Gene Tree for CCNO (if available)
TreeFam:
Gene Tree for CCNO (if available)

Paralogs for CCNO Gene

Paralogs for CCNO Gene

genes like me logo Genes that share paralogs with CCNO: view

Variants for CCNO Gene

Sequence variations from dbSNP and Humsavar for CCNO Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs151202 -- 55,233,776(+) GCCGG(A/G)GGGAG upstream-variant-2KB
rs151203 -- 55,234,691(+) GGCCT(G/T)AGTGA upstream-variant-2KB
rs163104 -- 55,233,802(+) GCGCC(A/C)GGCAC upstream-variant-2KB
rs163105 -- 55,234,608(+) CCGAC(C/T)GGGCG upstream-variant-2KB
rs163106 -- 55,235,163(+) GCCTG(A/G)CCAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCNO Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV Gain 17160897
dgv6070n71 CNV Loss 21882294

Relevant External Links for CCNO Gene

HapMap Linkage Disequilibrium report
CCNO
Human Gene Mutation Database (HGMD)
CCNO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNO Gene

Disorders for CCNO Gene

UniProtKB/Swiss-Prot

CCNO_HUMAN
  • Ciliary dyskinesia, primary, 29 (CILD29) [MIM:615872]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD29 patients do not exhibit situs inversus, a congenital abnormality in which visceral organs are opposite to their normal positions (situs solitus) due to lateral transposition. {ECO:0000269 PubMed:24747639}. Note=The disease is caused by mutations affecting the gene represented in this entry. Marked reduction of cilia in multiciliate cells due to defective mother centriole generation and placement. Remaining cilia correctly express axonemal motor proteins, are motile and do not show beating defects. Defects are probably caused by a strong reduction in the number of multiple motile cilia covering the cell surface in respiratory epithelial cells (PubMed:24747639). {ECO:0000269 PubMed:24747639}.

(2) Novoseek inferred disease relationships for CCNO Gene

Disease -log(P) Hits PubMed IDs
lymphoma b-cell 29.5 1
immunodeficiency 26.6 2

Relevant External Links for CCNO

Genetic Association Database (GAD)
CCNO
Human Genome Epidemiology (HuGE) Navigator
CCNO
genes like me logo Genes that share disorders with CCNO: view

Publications for CCNO Gene

  1. The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues. (PMID: 16697536) Hirst R. … Miller D. (Gene 2006) 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. (PMID: 2001396) Muller S.J. … Caradonna S. (Biochim. Biophys. Acta 1991) 3 4

Products for CCNO Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCNO
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCNO
    • Block miRNA regulation of CCNO using miScript Target Protectors

    Sources for CCNO Gene

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