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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNO Gene

protein-coding   GIFtS: 55
GCID: GC05M054526

Cyclin O

(Previous name: cyclin U)
(Previous symbol: CCNU)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin O1 2     Cyclin Domain Containing2
CCNU1 2     cyclin-O2
Cyclin U1 2     UNG25
UDG22     

External Ids:    HGNC: 185761   Entrez Gene: 103092   Ensembl: ENSG000001526697   OMIM: 6077525   UniProtKB: P226743   

Export aliases for CCNO gene to outside databases

Previous GC identifers: GC05M054564 GC05M054565 GC05M051499


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNO Gene:
This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed
ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family
member. The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so
confusion exists in the scientific literature and in some databases for these two genes.(provided by RefSeq, Nov
2010)

GeneCards Summary for CCNO Gene: 
CCNO (cyclin O) is a protein-coding gene. Diseases associated with CCNO include x-linked hyper igm syndrome, and herpes simplex, and among its related super-pathways are Base-free sugar-phosphate removal via the single-nucleotide replacement pathway and Removal of DNA patch containing abasic residue. GO annotations related to this gene include protein kinase binding and uracil DNA N-glycosylase activity. An important paralog of this gene is CCNE1.

Gene Wiki entry for CCNO (Cyclin O) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNO gene promoter:
         NF-1   Pax-6   CUTL1   Tal-1beta   Arnt   GATA-1   Pax-3   CP2   ZIC2/Zic2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNO promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

CCNO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNO gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M054526:  view genomic region     (about GC identifiers)

Start:
54,526,980 bp from pter      End:
54,529,508 bp from pter
Size:
2,529 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNO_HUMAN, P22674 (See protein sequence)
Recommended Name: Cyclin-O  
Size: 350 amino acids; 38096 Da
Developmental stage: Maximum levels during G(1) phase. Levels decrease through S and G(2) phases
Caution: Was originally thought to have uracil-DNA glycosylase (UDG) activity and wrongly named UNG2 and UDG2
(PubMed:2001396). It was later shown that it is a member of the cyclin family (PubMed:8419333). UNG2 corresponds
to the isoform 2 of UNG gene
Sequence caution: Sequence=AAB05817.1; Type=Miscellaneous discrepancy; Note=Sequencing errors;
Sequence=CAA36728.1; Type=Miscellaneous discrepancy; Note=Sequencing errors;
Secondary accessions: A8K1W5 Q0P6J2 Q9H6B0 Q9UMD5
Alternative splicing: 2 isoforms:  P22674-1   P22674-2   

Explore the universe of human proteins at neXtProt for CCNO: NX_P22674

Explore proteomics data for CCNO at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22674

  • CCNO Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNO Protein Expression
    REFSEQ proteins: NP_066970.3  
    ENSEMBL proteins: 
     ENSP00000422485   ENSP00000282572  
    Reactome Protein details: P22674
    Human Recombinant Protein Products for CCNO: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCNO
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCNO
    GenScript Custom Purified and Recombinant Proteins Services for CCNO
    Novus Biologicals CCNO Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNO 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    CCNO for ontologies           About GeneDecksing



    CCNO Antibody Products: 
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    Cloud-Clone Corp. Antibodies for CCNO 
    ThermoFisher Antibodies for CCNO
    LSBio Antibodies in human, mouse, rat for CCNO 

    Assay Products for CCNO: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CCNO 
    Cloud-Clone Corp. CLIAs for CCNO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P22674

    ProtoNet protein and cluster: P22674

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNO_HUMAN, P22674
    Similarity: Belongs to the cyclin family


    CCNO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004844uracil DNA N-glycosylase activity IDA12161446
    GO:0019901protein kinase binding IEA--
         
    CCNO for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNO 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNO 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNO 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNO
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCNO
    SwitchGear 3'UTR luciferase reporter plasmidCCNO 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCNO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNO

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CCNO

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCNO (see all 7)
    OriGene ORF clones in mouse, rat for CCNO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCNO (NM_021147)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNO
    Sirion Biotech Customized lentivirus for stable overexpression of CCNO 
                         Customized lentivirus expression plasmids for stable overexpression of CCNO 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNO


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCNO About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Base-Excision Repair, AP Site Formation
    Base-free sugar-phosphate removal via the single-nucleotide replacement pathway0.90
    Recognition and association of DNA glycosylase with site containing an affected pyrimidine0.62
    Displacement of DNA glycosylase by APE10.90
    Cleavage of the damaged pyrimidine 0.62
    Base-Excision Repair, AP Site Formation0.89
    Depyrimidination0.62
    Resolution of AP sites via the single-nucleotide replacement pathway0.83
    2Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Base Excision Repair0.89
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    Removal of DNA patch containing abasic residue0.89
    3Nucleotide Excision Repair
    DNA Repair0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/12        Reactome Pathways for CCNO (see all 12)
        Recognition and association of DNA glycosylase with site containing an affected pyrimidine
    Removal of DNA patch containing abasic residue
    DNA Repair
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway
    Base-Excision Repair, AP Site Formation



    CCNO for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for CCNO (P226742, 3 ENSP000002825724) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC1P188872, 3, ENSP000002628874MINT-7294888 MINT-7294905 I2D: score=1 STRING: ENSP00000262887
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    ITSN1Q158113, ENSP000003707194I2D: score=1 STRING: ENSP00000370719
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    RPA2P159273, ENSP000003630214I2D: score=2 STRING: ENSP00000363021
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0006281DNA repair TAS--
    GO:0006284base-excision repair TAS--
    GO:0006285base-excision repair, AP site formation TAS--
    GO:0007049cell cycle IDA8419333

    CCNO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCNO for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNO

    2 Novoseek inferred chemical compound relationships for CCNO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytosine 67.7 5 17537817 (2), 17272283 (1), 17101234 (1)
    cytidine 58 1 19023113 (1)

    Search CenterWatch for drugs/clinical trials and news about CCNO

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNO gene (2 alternative transcripts): 
    NM_001024592.1  NM_021147.3  

    Unigene Cluster for CCNO:

    Cyclin O
    Hs.3041  [show with all ESTs]
    Unigene Representative Sequence: BC004877
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000501463(uc003jpv.3) ENST00000282572(uc003jpw.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNO
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCNO
    SwitchGear 3'UTR luciferase reporter plasmidCCNO 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCNO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNO
    Clone
    Products:
         
    OriGene clones in human, mouse for CCNO (see all 7)
    OriGene ORF clones in mouse, rat for CCNO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCNO (NM_021147)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNO
    Sirion Biotech Customized lentivirus for stable overexpression of CCNO 
                         Customized lentivirus expression plasmids for stable overexpression of CCNO 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNO
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCNO
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNO
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNO

    Additional mRNA sequence: 

    AK026075.1 AK290030.1 BC004877.2 BC056254.1 BC143905.1 BC143907.1 

    5 DOTS entries:

    DT.411602  DT.120864645  DT.75102448  DT.92022702  DT.95164971 

    24/66 AceView cDNA sequences (see all 66):

    CA450228 BC017345 BM845204 AK026075 BU633834 AI590103 BU178239 BC056254 
    BC004877 BM760216 AW514938 BE139607 CB132051 AI769828 AW473056 BI118165 
    BM761929 AI811909 AI949695 AI769465 BU632263 AW070688 CB142389 AW731934 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CCNO    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
    SP1:        -     -     -                           
    SP2:                                                
    SP3:                    -                           
    SP4:                                                


    ECgene alternative splicing isoforms for CCNO

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNO expression in normal human tissues (normalized intensities)      CCNO embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAGCTGA
    CCNO Expression
    About this image


    CCNO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             brain/forebrain/telencephalon   
     
     Epithelium (Respiratory System)    fully expand to see all 3 entries
             bronchial epithelia   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem ES-209, Meso-prx/latp Progenitor
     
     Ovary (Reproductive System)
             Secondary follicles

    See CCNO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNO

    SOURCE GeneReport for Unigene cluster: Hs.3041
        SABiosciences Expression via Pathway-Focused PCR Array including CCNO: 
              DNA Repair in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCNO
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNO
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CCNO gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccno1 , 5 cyclin O1, 5 81.61(n)1
    81.03(a)1
      13 (63.93 cM)5
    2186301  NM_001081062.11  NP_001074531.11 
     1129878025 
    chicken
    (Gallus gallus)
    Aves LOC1008573931 cyclin-O-like 73.9(n)
    67.83(a)
      100857393  XM_003642984.1  XP_003643032.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNO6
    Uncharacterized protein
    58(a)
    1 ↔ 1
    2(2606877-2612448)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.339422 Xenopus laevis transcribed sequences 74.88(n)    BJ627795.1 
    zebrafish
    (Danio rerio)
    Actinopterygii --
    --
    18(a)
    possible ortholog
    18(38995641-39005628)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLB66
    CLB36
    (see all 6)
    B-type cyclin involved in DNA replication during S...
    B-type cyclin involved in cell cycle progression; ...
    (see all 6)
    18(a)
    14(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    VII(705359-706501)
    IV(176773-178056)


    ENSEMBL Gene Tree for CCNO (if available)
    TreeFam Gene Tree for CCNO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNO gene
    CCNE12  CCND32  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  

    CCNO for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/149 SNPs in CCNO are shown (see all 149)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1380267211,2
    --51504521(+) TTTTTC/GAGACA 1 -- us2k10--------
    rs744966761,2
    F--54526593(+) CAATGG/TCTGTG 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1898356011,2
    --54526629(+) ACATGC/TTCCAT 1 -- int10--------
    rs1925418251,2
    --54526662(+) CTGGAA/TATGGC 1 -- int10--------
    rs797649711,2
    C,F--54526697(+) CTGTGT/GGGTCC 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1849288881,2
    --54526729(+) TCTGCC/TTCACC 1 -- int10--------
    rs762961751,2
    C,F--54526980(+) CAGGAT/CTTAGA 1 -- ut311Minor allele frequency- C:0.02NA 120
    rs1898620851,2
    --54527001(+) CTGTTA/TATTGG 1 -- ut310--------
    rs1159639441,2
    C,F--54527064(+) TGCTAG/ATATCG 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1148473121,2
    C,F--54527151(+) GCTACG/CGGAGA 1 -- ut311Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for CCNO (54526980 - 54529508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCNO:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6070n71CNV Loss21882294
    nsv830302CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNO
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607752    OMIM disorders: --

    4 diseases for CCNO:    About MalaCards
    x-linked hyper igm syndrome    herpes simplex    pancreatic cancer    pancreatitis


    CCNO for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CCNO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 29.5 1 17062624 (1)
    immunodeficiency 26.6 3 17062624 (1), 17272283 (1)

    Genetic Association Database (GAD): CCNO
    Human Genome Epidemiology (HuGE) Navigator: CCNO (1 document)

    Export disorders for CCNO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNO gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with CCNO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. (PubMed id 8419333)1, 2 Muller S.J. and Caradonna S. (1993)
    5. Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. (PubMed id 2001396)1, 2 Muller S.J. and Caradonna S. (1991)
    6. The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues. (PubMed id 16697536)2, 9 Hirst R.... Miller D. (2006)
    7. The HIV1 protein Vpr acts to enhance constitutive DCAF 1-dependent UNG2 turnover. (PubMed id 22292079)1 Wen X....de Noronha C.M. (2012)
    8. Uracil DNA N-glycosylase promotes assembly of human c entromere protein A. (PubMed id 21399697)1 Zeitlin S.G....Wang J.Y. (2011)
    9. The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 comple x dimerizes via a short helical region in DCAF1. (PubMed id 21226479)1 Ahn J....Gronenborn A.M. (2011)
    10. HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for pro teasome-dependent degradation. (PubMed id 20870715)1 Ahn J....Gronenborn A.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10309 HGNC: 18576 AceView: UNG2 Ensembl:ENSG00000152669 euGenes: HUgn10309
    ECgene: CCNO H-InvDB: CCNO

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNO gene:
    Search GeneIP for patents involving CCNO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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