External Ids for CCNO Gene
Previous HGNC Symbols for CCNO Gene
Previous GeneCards Identifiers for CCNO Gene
This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]
GeneCards Summary for CCNO Gene
CCNO (Cyclin O) is a Protein Coding gene. Diseases associated with CCNO include primary ciliary dyskinesia29: ccno-related primary ciliary dyskinesia and ciliary dyskinesia, primary, 29. GO annotations related to this gene include protein kinase binding and uracil DNA N-glycosylase activity. An important paralog of this gene is CCND2.
UniProtKB/Swiss-Prot for CCNO Gene
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.