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CCNL2 Gene

protein-coding   GIFtS: 47
GCID: GC01M001321

Cyclin L2

(Previous name: cyclin M)
(Previous symbol: CCNM)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin L21 2     HCLA-ISO2
CCNM1 2     HLA-ISO2
Cyclin M1 2     PCEE2
Paneth Cell-Enhanced Expression Protein2 3     SB1382
ANIA-6B2     cyclin-L22

External Ids:    HGNC: 205701   Entrez Gene: 816692   Ensembl: ENSG000002219787   OMIM: 6134825   UniProtKB: Q96S943   

Export aliases for CCNL2 gene to outside databases

Previous GC identifers: GC01M001073 GC01M001247 GC01M001276 GC01P9A0164 GC01P8D0164 GC01M001312 GC01M000593


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNL2 Gene:
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such
as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of
the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and
antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described
for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for CCNL2 Gene:
CCNL2 (cyclin L2) is a protein-coding gene. Diseases associated with CCNL2 include hepatocellular carcinoma, and lung cancer. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNT2.

UniProtKB/Swiss-Prot: CCNL2_HUMAN, Q96S94
Function: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates
the expression of critical apoptotic factor, leading to cell apoptosis

Gene Wiki entry for CCNL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNL2 gene promoter:
         NCX/Ncx   MyoD   Lmo2   Tal-1beta   Gfi-1   E47   POU2F1   POU2F1a   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CCNL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

CCNL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNL2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001321:  view genomic region     (about GC identifiers)

Start:
1,321,091 bp from pter      End:
1,334,718 bp from pter
Size:
13,628 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCNL2_HUMAN, Q96S94 (See protein sequence)
Recommended Name: Cyclin-L2  
Size: 520 amino acids; 58147 Da
Subunit: Interacts with CDK11A, CDK11B, CDK12, CDK13, SFRS2, SFRS7 and POLR2A, the hyperphosphorylated C-terminal
domain (CTD) of RNA polymerase II
Sequence caution: Sequence=AAH71622.2; Type=Erroneous initiation; Sequence=BAB84938.1; Type=Erroneous initiation;
Secondary accessions: A8K8A3 B1B152 Q5T2N5 Q5T2N6 Q6IQ12 Q7Z4Z8 Q8N3C9 Q8N3D5 Q8NHE3 Q8TEL0
Q96B00
Alternative splicing: 3 isoforms:  Q96S94-1   Q96S94-2   Q96S94-3   (Ref.1 (AAM76789) sequence is in conflict in position: 226:K->IT)

Explore the universe of human proteins at neXtProt for CCNL2: NX_Q96S94

Explore proteomics data for CCNL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCNL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034666.1  NP_112199.2  

    ENSEMBL proteins: 
     ENSP00000462056   ENSP00000383611   ENSP00000423734   ENSP00000424647   ENSP00000386158  
     ENSP00000392899   ENSP00000464685   ENSP00000386132  

    CCNL2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCNL2
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    Cloud-Clone Corp. Proteins for CCNL2

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    LSBio Antibodies in human, mouse, rat for CCNL2

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    Cloud-Clone Corp. CLIAs for CCNL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR017060 Cyclin_L
     IPR015429 Cyclin_C/H/T/L

    Graphical View of Domain Structure for InterPro Entry Q96S94

    ProtoNet protein and cluster: Q96S94

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNL2_HUMAN, Q96S94
    Domain: Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark
    of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By
    similarity)
    Similarity: Belongs to the cyclin family. Cyclin L subfamily


    CCNL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNL2_HUMAN, Q96S94
    Function: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Also modulates
    the expression of critical apoptotic factor, leading to cell apoptosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019901protein kinase binding IEA--
         
    CCNL2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNL2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNL2

    miRNA
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    miRTarBase miRNAs that target CCNL2:
    hsa-mir-26b-5p (MIRT030118)

    Block miRNA regulation of human, mouse, rat CCNL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNL2 (see all 52):
    hsa-miR-596 hsa-miR-3194-5p hsa-miR-200a hsa-miR-29a hsa-miR-578 hsa-miR-138-2* hsa-miR-141 hsa-miR-548m
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNL2

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    GenScript: all cDNA clones in your preferred vector (see all 2): CCNL2 (NM_001039577)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNL2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNL2_HUMAN, Q96S94: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17494991
    GO:0016607nuclear speck IEA--

    CCNL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCNL2
    Interactions:

        GeneGlobe Interaction Network for CCNL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNL2 (Q96S943 ENSP000003836114) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYRK1AQ136273, ENSP000003819324I2D: score=2 STRING: ENSP00000381932
    POLR2AP249283, ENSP000003149494I2D: score=2 STRING: ENSP00000314949
    SRSF2Q011303, ENSP000003508774I2D: score=1 STRING: ENSP00000350877
    SRSF7Q166293, ENSP000003259054I2D: score=1 STRING: ENSP00000325905
    CDK11AQ9UQ883, ENSP000003844424I2D: score=1 STRING: ENSP00000384442
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006396RNA processing IEA--

    CCNL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNL2

    1 Novoseek inferred chemical compound relationship for CCNL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 43.9 3 14623875 (2), 17494991 (1)



    CCNL2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCNL2 gene (4 alternative transcripts): 
    NM_001039577.3  NM_030937.4  NM_001144867.1  NM_001144868.1  

    Unigene Cluster for CCNL2:

    Cyclin L2
    Hs.515704  [show with all ESTs]
    Unigene Representative Sequence: NM_030937
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000480479(uc010nym.1 uc001afg.1 uc001afi.2 uc001afj.2)
    ENST00000482621 ENST00000463260 ENST00000400809 ENST00000496007(uc001aff.1 uc021oep.1)
    ENST00000482365 ENST00000481223 ENST00000418865 ENST00000505849 ENST00000488340
    ENST00000492998 ENST00000469113 ENST00000480646 ENST00000471930 ENST00000408918
    ENST00000473872 ENST00000425598 ENST00000463895
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCNL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNL2 (see all 52):
    hsa-miR-596 hsa-miR-3194-5p hsa-miR-200a hsa-miR-29a hsa-miR-578 hsa-miR-138-2* hsa-miR-141 hsa-miR-548m
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCNL2
    Predesigned siRNA for gene silencing in human, mouse, rat CCNL2
    Clone
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    OriGene ORF clones in mouse, rat for CCNL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCNL2 (NM_001039577)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNL2
    Primer
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    OriGene qPCR primer pairs and template standards for CCNL2
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNL2
      QuantiTect SYBR Green Assays in human, mouse, rat CCNL2
      QuantiFast Probe-based Assays in human, mouse, rat CCNL2

    Additional mRNA sequence: 

    AF087903.1 AF251294.1 AK000685.1 AK026796.1 AK027770.1 AK056120.1 AK057133.1 AK225758.1 
    AK292268.1 AK293451.1 AL834432.1 AL834441.1 AY037150.1 BC016333.1 BC071622.1 

    Selected DOTS entries (see all 41):

    DT.100649805  DT.91757120  DT.86780790  DT.99932236  DT.100757555  DT.121375226  DT.91866937  DT.101984606 
    DT.100827562  DT.97860614  DT.97811707  DT.121375185  DT.121375220  DT.121375124  DT.95161912  DT.101984605 
    DT.121375107  DT.121375134  DT.121375227  DT.95161932  DT.121375188  DT.95161913  DT.121375097  DT.121375132 

    Selected AceView cDNA sequences (see all 187):

    AL527409 BP367272 AI338745 BU857945 BM504784 BF001218 AI700009 BQ672062 
    AI681658 AI658954 BE019565 BP358686 AI990518 AI335583 AA371353 AW160397 
    AI082366 CB119346 Z42901 AI523882 AI961043 BE386268 BU682874 AI609688 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTAATAC
    CCNL2 Expression
    About this image


    CCNL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
    CCNL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515704

    UniProtKB/Swiss-Prot: CCNL2_HUMAN, Q96S94
    Tissue specificity: Ubiquitously expressed, with a higher expression level observed in ovary, heart, liver and
    pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CCNL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnl21 , 5 cyclin L21, 5 85.76(n)1
    91.58(a)1
      4 (87.47 cM)5
    560361  NM_207678.11  NP_997561.11 
     1558124895 
    chicken
    (Gallus gallus)
    Aves CCNL21 cyclin L2 75.93(n)
    84.77(a)
      395124  NM_204470.2  NP_989801.2 
    lizard
    (Anolis carolinensis)
    Reptilia CCNL26
    cyclin L2
    77(a)
    1 ↔ 1
    GL343701.1(53195-67246)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165422 Xenopus laevis transcribed sequence with moderate similarity more 78.95(n)    BQ727551.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169036
    --
    42(a)
    1 → many
    X(1972376-1974438)
    worm
    (Caenorhabditis elegans)
    Secernentea cyl-16
    Protein CYL-1, isoform a (cyl-1) mRNA, complete cd...
    34(a)
    1 → many
    V(11991010-11993767) WBGene00000876
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSN86
    Cyclin-like component of the RNA polymerase II hol...
    20(a)
    1 → many
    XIV(584320-585291) YNL025C


    ENSEMBL Gene Tree for CCNL2 (if available)
    TreeFam Gene Tree for CCNL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNL2 gene
    CCNT22  CCNK2  CCNC2  CCNL12  FAM58A2  CCNT12  
    3 SIMAP similar genes for CCNL2 using alignment to 5 protein entries:     CCNL2_HUMAN (see all proteins):
    CCNL1    FAM58A    CYCT1b

    CCNL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCNL2
    PGOHUM00000263127


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNL2 (see all 416)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829596361,2
    --1303380(+) CCCGGC/GTTCAA 1 -- ds50010--------
    rs1121977111,2
    C,F--1303405(+) TCAGCC/TTCCTG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1410938261,2
    --1303410(+) CTCCTC/GAGTAG 1 -- ds50010--------
    rs1858365491,2
    --1303526(+) GATCCA/GCCTGC 1 -- ds50010--------
    rs49704441,2
    C,F,A--1303553(+) gctggA/Gattac 1 -- ds50018Minor allele frequency- G:0.12NA WA CSA 17
    rs1902091091,2
    --1303563(+) CAGGCA/GTAAGC 1 -- ds50010--------
    rs288126231,2
    C--1303678(-) AGCGCC/TGTGGG 1 -- ds50010--------
    rs288336211,2
    C--1303696(-) GCTCAG/CGCCTG 1 -- ds50011Minor allele frequency- C:0.50NA 2
    rs96612881,2
    C--1303722(-) agcgcT/Cgtggg 1 -- ds50014Minor allele frequency- C:0.00NA 10
    rs1824934081,2
    --1303796(+) ACCGCA/GCCCGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCNL2 (1321091 - 1334718 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CCNL2 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv12n71CNV Loss21882294
    dgv25n71CNV Loss21882294
    dgv19n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv34n71CNV Loss21882294
    nsv871837CNV Loss21882294
    dgv33n71CNV Loss21882294
    dgv20n71CNV Loss21882294
    dgv38n71CNV Loss21882294
    dgv31n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613482    OMIM disorders: --

    3 diseases for CCNL2:    
    About MalaCards
    hepatocellular carcinoma    lung cancer    cerebritis


    CCNL2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CCNL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 14684736 (2)


    Export disorders for CCNL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNL2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CCNL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. (PubMed id 14684736)1, 2, 9 Yang L.... Cao X. (J. Biol. Chem. 2004)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors. (PubMed id 14623875)1, 9 de Graaf K.... Becker W. (J. Biol. Chem. 2004)
    6. Characterization of cyclin L1 as an immobile component of the splicing factor compartment. (PubMed id 17494991)1, 9 Herrmann A....Becker W. (FASEB J. 2007)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. (PubMed id 24218572)1 Guen V.J....Colas P. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81669 HGNC: 20570 AceView: CCNL2 Ensembl:ENSG00000221978 euGenes: HUgn81669
    ECgene: CCNL2 H-InvDB: CCNL2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCNL2 gene:
    Search GeneIP for patents involving CCNL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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