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Aliases for CCNL1 Gene

Aliases for CCNL1 Gene

  • Cyclin L1 2 3 5
  • Cyclin-L 3 4
  • Cyclin L Ania-6a 3
  • Cyclin L Gamma 3
  • Cyclin-L1 3
  • PRO1073 3
  • Ania-6a 3
  • ANIA6A 3
  • BM-001 3

External Ids for CCNL1 Gene

Previous GeneCards Identifiers for CCNL1 Gene

  • GC03M157812
  • GC03M158147
  • GC03M158186
  • GC03M158348
  • GC03M156864
  • GC03M154261

Summaries for CCNL1 Gene

GeneCards Summary for CCNL1 Gene

CCNL1 (Cyclin L1) is a Protein Coding gene. Diseases associated with CCNL1 include Squamous Cell Carcinoma, Head And Neck. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNL2.

UniProtKB/Swiss-Prot for CCNL1 Gene

  • Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).

Gene Wiki entry for CCNL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNL1 Gene

Genomics for CCNL1 Gene

Regulatory Elements for CCNL1 Gene

Enhancers for CCNL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F157150 2.5 Ensembl ENCODE 24.1 +4.2 4200 11.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC KRT18P34 CCNL1 METTL15P1 ENSG00000243176 LINC00880 ENSG00000201778
GH03F157124 2 VISTA FANTOM5 Ensembl ENCODE 24 +29.3 29312 13.5 HDGF PKNOX1 MLX ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 KRT18P34 CCNL1 LEKR1 LINC00880 ENSG00000241770 TIPARP SSR3 TIPARP-AS1 GC03M157131
GH03F157085 1.4 FANTOM5 ENCODE 22.7 +72.1 72067 6.2 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CCNL1 TIPARP TIPARP-AS1 ENSG00000241770 KRT18P34 SSR3 KCNAB1-AS1 LINC00881 LINC02029
GH03F156673 1.7 FANTOM5 Ensembl ENCODE 18.2 +480.3 480250 14.4 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 LINC00886 LEKR1 CCNL1 SSR3 TIPARP-AS1 TIPARP PIR33904 METTL15P1
GH03F157173 1.2 ENCODE 24.1 -14.5 -14476 3.6 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 KRT18P34 CCNL1 PA2G4P4 ENSG00000243176 LOC100420048
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNL1 on UCSC Golden Path with GeneCards custom track

Promoters for CCNL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001377732 1560 4001 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for CCNL1 Gene

Chromosome:
3
Start:
157,146,364 bp from pter
End:
157,160,760 bp from pter
Size:
14,397 bases
Orientation:
Minus strand

Genomic View for CCNL1 Gene

Genes around CCNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNL1 Gene

Proteins for CCNL1 Gene

  • Protein details for CCNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK58-CCNL1_HUMAN
    Recommended name:
    Cyclin-L1
    Protein Accession:
    Q9UK58
    Secondary Accessions:
    • B3KMY3
    • C9JPL0
    • Q6NVY9
    • Q6UWS7
    • Q8NI48
    • Q96QT0
    • Q9NZF3

    Protein attributes for CCNL1 Gene

    Size:
    526 amino acids
    Molecular mass:
    59634 Da
    Quaternary structure:
    • Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK12 and CDK13 (PubMed:11980906, PubMed:18216018). Isoforms 1 and 2, but not isoform 3, interact with CDK11B. May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:11980906, PubMed:18216018).
    Miscellaneous:
    • CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC.
    SequenceCaution:
    • Sequence=AAF64257.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAQ89026.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNL1 Gene

Post-translational modifications for CCNL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNL1 Gene

Domains & Families for CCNL1 Gene

Gene Families for CCNL1 Gene

Protein Domains for CCNL1 Gene

Suggested Antigen Peptide Sequences for CCNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK58

UniProtKB/Swiss-Prot:

CCNL1_HUMAN :
  • Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
  • Belongs to the cyclin family. Cyclin L subfamily.
Domain:
  • Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
Family:
  • Belongs to the cyclin family. Cyclin L subfamily.
genes like me logo Genes that share domains with CCNL1: view

Function for CCNL1 Gene

Molecular function for CCNL1 Gene

GENATLAS Biochemistry:
cyclin like 1,most likely member of a new family of cyclins,with homology to mouse cyclin G
UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).

Gene Ontology (GO) - Molecular Function for CCNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNL1: view
genes like me logo Genes that share phenotypes with CCNL1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNL1 Gene

Localization for CCNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNL1 Gene

Nucleus speckle. Nucleus, nucleoplasm. Note=Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNL1 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CCNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA --
GO:0005634 nucleus IDA 17494991
GO:0005654 nucleoplasm IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with CCNL1: view

Pathways & Interactions for CCNL1 Gene

SuperPathways for CCNL1 Gene

No Data Available

Pathways by source for CCNL1 Gene

1 GeneTex pathway for CCNL1 Gene

Gene Ontology (GO) - Biological Process for CCNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing IEA --
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with CCNL1: view

No data available for SIGNOR curated interactions for CCNL1 Gene

Transcripts for CCNL1 Gene

Unigene Clusters for CCNL1 Gene

Cyclin L1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNL1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5:
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: - - - - -
SP10:
SP11: - -
SP12: - - -
SP13: - - -
SP14:
SP15: -
SP16: - - - -
SP17:
SP18: - - -

ExUns: 11d ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17: -
SP18:

Relevant External Links for CCNL1 Gene

GeneLoc Exon Structure for
CCNL1
ECgene alternative splicing isoforms for
CCNL1

Expression for CCNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNL1 Gene

This gene is overexpressed in Heart (46.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCNL1 Gene



Protein tissue co-expression partners for CCNL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNL1 Gene:

CCNL1

SOURCE GeneReport for Unigene cluster for CCNL1 Gene:

Hs.4859

mRNA Expression by UniProt/SwissProt for CCNL1 Gene:

Q9UK58-CCNL1_HUMAN
Tissue specificity: Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
genes like me logo Genes that share expression patterns with CCNL1: view

Primer Products

No data available for mRNA differential expression in normal tissues for CCNL1 Gene

Orthologs for CCNL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNL1 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia CCNL1 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNL1 34 35
  • 95.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNL1 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnl1 34 16 35
  • 93.09 (n)
rat
(Rattus norvegicus)
Mammalia Ccnl1 34
  • 93.03 (n)
oppossum
(Monodelphis domestica)
Mammalia CCNL1 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNL1 34 35
  • 81.77 (n)
lizard
(Anolis carolinensis)
Reptilia CCNL1 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccnl1a 34 35
  • 70.36 (n)
ccnl1b 35
  • 66 (a)
OneToMany
Dr.28373 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13166 34
fruit fly
(Drosophila melanogaster)
Insecta CG16903 35
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyl-1 35
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN8 35
  • 20 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.1541 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11553 34
Species where no ortholog for CCNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCNL1 Gene

ENSEMBL:
Gene Tree for CCNL1 (if available)
TreeFam:
Gene Tree for CCNL1 (if available)

Paralogs for CCNL1 Gene

Paralogs for CCNL1 Gene

(2) SIMAP similar genes for CCNL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCNL1: view

Variants for CCNL1 Gene

Sequence variations from dbSNP and Humsavar for CCNL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10653337 -- 157,157,392(+) TAAAC(-/TCTT)TAGTC intron-variant
rs10685249 -- 157,157,393(+) AAACT(-/CTTT/TCTT)AGTCT intron-variant
rs10936061 -- 157,159,568(+) TTCCC(C/T)TTCCC intron-variant
rs10936062 -- 157,159,654(+) CGCCC(C/T)GGCCG intron-variant
rs111389559 -- 157,150,055(+) GTAAA(C/T)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNL1 Gene

Variant ID Type Subtype PubMed ID
nsv829766 CNV gain 17160897
nsv819788 CNV loss 19587683
nsv520331 CNV loss 19592680
esv2660786 CNV deletion 23128226

Variation tolerance for CCNL1 Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNL1 Gene

Disorders for CCNL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCNL1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • squamous cell carcinoma, head and neck, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CCNL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNL1

Human Genome Epidemiology (HuGE) Navigator
CCNL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNL1
genes like me logo Genes that share disorders with CCNL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNL1 Gene

Publications for CCNL1 Gene

  1. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. (PMID: 18216018) Loyer P. … Lahti J.M. (J. Biol. Chem. 2008) 3 4 22 64
  2. Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC). (PMID: 15700036) Sticht C. … Joos S. (Br. J. Cancer 2005) 3 4 22 64
  3. Cyclin L is an RS domain protein involved in pre-mRNA splicing. (PMID: 11980906) Dickinson L.A. … Gottesfeld J.M. (J. Biol. Chem. 2002) 2 3 4 64
  4. Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer. (PMID: 12414649) Redon R. … du Manoir S. (Cancer Res. 2002) 3 4 22 64
  5. Characterization of cyclin L1 as an immobile component of the splicing factor compartment. (PMID: 17494991) Herrmann A. … Becker W. (FASEB J. 2007) 3 22 64

Products for CCNL1 Gene

Sources for CCNL1 Gene

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