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CCNL1 Gene

protein-coding   GIFtS: 55
GCID: GC03M156864

Cyclin L1

  Search for CCNL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin L11 2     Cyclin L Gamma2
ANIA6A2 5     cyclin-L2
PRO10732     cyclin-L12
ania-6a2     Cyclin-L3
Cyclin L Ania-6a2     

External Ids:    HGNC: 205691   Entrez Gene: 570182   Ensembl: ENSG000001636607   OMIM: 6133845   UniProtKB: Q9UK583   

Export aliases for CCNL1 gene to outside databases

Previous GC identifers: GC03M157812 GC03M158147 GC03M158186 GC03M158348 GC03M154261


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCNL1 Gene:
CCNL1 (cyclin L1) is a protein-coding gene. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNL2.

UniProtKB/Swiss-Prot: CCNL1_HUMAN, Q9UK58
Function: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be
involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases
(CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous
cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21

Gene Wiki entry for CCNL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNL1 gene promoter:
         AML1a   GCNF   FOXD1   FOXL1   GATA-2   AREB6   GCNF-1   FOXO1a   GCNF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNL1 promoter sequence
   Search Chromatin IP Primers for CCNL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.31   Ensembl cytogenetic band:  3q25.31   HGNC cytogenetic band: 3q25.31

CCNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNL1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M156864:  view genomic region     (about GC identifiers)

Start:
156,864,297 bp from pter      End:
156,878,549 bp from pter
Size:
14,253 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCNL1_HUMAN, Q9UK58 (See protein sequence)
Recommended Name: Cyclin-L1  
Size: 526 amino acids; 59634 Da
Subunit: Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with
CDK11A, CDK11B, CDK12, CDK13 and SFRS2
Miscellaneous: CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional
metastases and an unfavorable clinical outcome of HNSCC
Sequence caution: Sequence=AAF64257.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=AAQ89026.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: B3KMY3 Q6NVY9 Q6UWS7 Q8NI48 Q96QT0 Q9NZF3
Alternative splicing: 3 isoforms:  Q9UK58-1   Q9UK58-4   Q9UK58-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CCNL1: NX_Q9UK58

Explore proteomics data for CCNL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCNL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064703.1  
    ENSEMBL proteins: 
     ENSP00000420277   ENSP00000295926   ENSP00000417343   ENSP00000417237   ENSP00000417218  
     ENSP00000418449   ENSP00000418094   ENSP00000295925  

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    Novus Biologicals CCNL1 Protein
    Novus Biologicals CCNL1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNL1

     
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    Search eBioscience for ELISAs for CCNL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR017060 Cyclin_L
     IPR015429 Cyclin_C/H/T/L
     IPR015431 Cyclin_L1_met

    Graphical View of Domain Structure for InterPro Entry Q9UK58

    ProtoNet protein and cluster: Q9UK58

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNL1_HUMAN, Q9UK58
    Domain: Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark
    of the SR family of splicing factors. This region probably plays a role in protein-protein interactions
    Similarity: Belongs to the cyclin family. Cyclin L subfamily


    Find genes that share domains with CCNL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNL1_HUMAN, Q9UK58
    Function: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be
    involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases
    (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous
    cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21

         Genatlas biochemistry entry for CCNL1:
    cyclin like 1,most likely member of a new family of cyclins,with homology to mouse cyclin G

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019901protein kinase binding IEA--
         
    Find genes that share ontologies with CCNL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCNL1:
     Decreased viability 

    Animal Models:
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    miRTarBase miRNAs that target CCNL1:
    hsa-mir-34a-5p (MIRT025231), hsa-mir-199a-3p (MIRT006586), hsa-mir-18a-5p (MIRT004383), hsa-mir-19b-3p (MIRT031118), hsa-mir-199a-5p (MIRT003963)

    Block miRNA regulation of human, mouse, rat CCNL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNL1 (see all 19):
    hsa-miR-4288 hsa-miR-3942-5p hsa-miR-346 hsa-miR-632 hsa-miR-548l hsa-miR-7-1* hsa-miR-199b-5p hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmidCCNL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNL1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNL1_HUMAN, Q9UK58: Nucleus speckle (By similarity). Note=More specifically found in nuclear intrachromatin
    granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins
    involved in mRNA processing (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17494991
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with CCNL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCNL1
    Interactions:

        Search GeneGlobe Interaction Network for CCNL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNL1 (Q9UK583 ENSP000002959264) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRSF2Q011303, ENSP000003508774I2D: score=1 STRING: ENSP00000350877
    CDK11AQ9UQ883, ENSP000003844424I2D: score=1 STRING: ENSP00000384442
    APPBP2Q926243I2D: score=1 
    MDFIQ997503I2D: score=1 
    MCM2ENSP000002650564STRING: ENSP00000265056
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006396RNA processing IEA--

    Find genes that share ontologies with CCNL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNL1 gene: 
    NM_020307.2  

    Unigene Cluster for CCNL1:

    Cyclin L1
    Hs.4859  [show with all ESTs]
    Unigene Representative Sequence: BX641146
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000461804(uc003fbd.1 uc003fbi.1) ENST00000295926(uc003fbf.3)
    ENST00000464316(uc003fbe.3) ENST00000471247 ENST00000474539 ENST00000475298(uc003fbg.3 uc011bor.2)
    ENST00000476744 ENST00000470121 ENST00000468977 ENST00000467849 ENST00000476367
    ENST00000477127 ENST00000464679 ENST00000495471 ENST00000481173 ENST00000479052
    ENST00000483789 ENST00000478454
    miRNA
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    Block miRNA regulation of human, mouse, rat CCNL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNL1 (see all 19):
    hsa-miR-4288 hsa-miR-3942-5p hsa-miR-346 hsa-miR-632 hsa-miR-548l hsa-miR-7-1* hsa-miR-199b-5p hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmidCCNL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCNL1
    Predesigned siRNA for gene silencing in human, mouse, rat CCNL1
    Clone
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    OriGene clones in human, mouse for CCNL1 (see all 7)
    OriGene ORF clones in mouse, rat for CCNL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCNL1 (NM_020307)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNL1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCNL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNL1
      QuantiTect SYBR Green Assays in human, mouse, rat CCNL1
      QuantiFast Probe-based Assays in human, mouse, rat CCNL1

    Additional mRNA sequence: 

    AF180920.1 AF208843.1 AF367476.1 AF367477.1 AK022974.1 AK098021.1 AK122738.1 AK125606.1 
    AY034790.1 AY358663.1 BC007081.1 BC038394.1 BC067812.1 BX641146.1 BX647554.1 

    Selected DOTS entries (see all 26):

    DT.442945  DT.100664810  DT.99987197  DT.91975143  DT.100660246  DT.101981164  DT.97817291  DT.99950023 
    DT.100892737  DT.97814388  DT.100837700  DT.100892717  DT.100711707  DT.100892735  DT.91772288  DT.101986367 
    DT.120881980  DT.95080806  DT.95080812  DT.100037644  DT.100773442  DT.120881984  DT.120881992  DT.91785442 

    Selected AceView cDNA sequences (see all 377):

    CA418724 CB528461 AU157680 AF367477 BE676579 BU070642 AK098021 CB052743 
    AI096423 BQ180877 BC067812 AW575633 BF445398 AA152106 AA328216 AU155964 
    BU188742 CB105093 AY358663 AL598242 AA677166 BM971212 CA427304 AW081919 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCNL1 (see all 18)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ·
    SP1:                          -                 -     -     -                       -                 -     -                 -                                 
    SP2:                          -                 -           -                       -                 -     -           -     -                                 
    SP3:                          -                 -     -     -                       -                 -     -     -     -     -                                 
    SP4:                          -                 -     -     -                       -                 -     -     -     -     -                                 
    SP5:                                                                                                                                                            

    ExUns: 11d ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
    SP1:  -           -           -                           
    SP2:  -           -           -                           
    SP3:  -           -           -                           
    SP4:  -           -           -     -     -     -         
    SP5:  -           -           -                           


    ECgene alternative splicing isoforms for CCNL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAAGATT
    CCNL1 Expression
    About this image


    CCNL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
     
     Ovary (Reproductive System)
    CCNL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.4859

    UniProtKB/Swiss-Prot: CCNL1_HUMAN, Q9UK58
    Tissue specificity: Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck
    squamous cell carcinomas (HNSCC)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNL1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnl11 , 5 cyclin L11, 5 93.09(n)1
    98.15(a)1
      3 (30.25 cM)5
    567061  NM_019937.31  NP_064321.21 
     659461515 
    chicken
    (Gallus gallus)
    Aves CCNL11 cyclin L1 81.77(n)
    93.66(a)
      425024  XM_422826.4  XP_422826.4 
    lizard
    (Anolis carolinensis)
    Reptilia CCNL16
    cyclin L1
    78(a)
    1 ↔ 1
    3(15022965-15038123)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU914792.12   -- 79.89(n)    BU914792.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283732 Danio rerio cDNA clone IMAGE6790900, partial cds 74.18(n)    BC057418.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169036
    --
    43(a)
    1 → many
    X(1972376-1974438)
    worm
    (Caenorhabditis elegans)
    Secernentea cyl-16
    Protein CYL-1, isoform a (cyl-1) mRNA, complete cd...
    36(a)
    1 → many
    V(11991010-11993767) WBGene00000876
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSN86
    Cyclin-like component of the RNA polymerase II hol...
    20(a)
    1 → many
    XIV(584320-585291) YNL025C
    rice
    (Oryza sativa)
    Liliopsida Os.15412 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.56(n)    AK069233.1 


    ENSEMBL Gene Tree for CCNL1 (if available)
    TreeFam Gene Tree for CCNL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNL1 gene
    CCNL22  CCNT22  CCNK2  CCNC2  FAM58A2  CCNT12  
    2 SIMAP similar genes for CCNL1 using alignment to 3 protein entries:     CCNL1_HUMAN (see all proteins):
    CCNL2    FAM58A

    Find genes that share paralogs with CCNL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNL1 (see all 313)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927735421,2
    --156865096(+) ATTCCA/GGCTTT 1 -- ds50010--------
    rs1854975401,2
    --156865264(+) ATTCAA/TTAGGG 1 -- ds50010--------
    rs67714651,2
    C,F,H--156865338(+) CAAATC/GAGGTT 1 -- ds50016Minor allele frequency- G:0.09NS EA WA 538
    rs1907984601,2
    C--156865369(+) ATAACA/CTTTAA 1 -- ds50010--------
    rs1427558741,2
    C--156865390(+) TTGGGC/TGACTC 1 -- ds50010--------
    rs1510348581,2
    --156865499(+) AAAGAA/GTAAGT 1 -- ds50010--------
    rs1817134931,2
    --156865640(+) ATGCAC/GACAAA 1 -- ut310--------
    rs115462461,2
    C,H--156865800(+) AAGTAC/TAATTG 1 -- ut312Minor allele frequency- T:0.01NS NA 174
    rs1843556781,2
    --156865947(+) TTTGCA/GTTTAA 1 -- ut310--------
    rs1181448371,2
    C,F--156865958(+) TGTTTT/CTGATT 1 -- ut311Minor allele frequency- C:0.04EA 120

    HapMap Linkage Disequilibrium report for CCNL1 (156864297 - 156878549 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCNL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660786CNV Deletion23128226
    nsv520331CNV Loss19592680
    nsv819788CNV Loss19587683
    nsv829766CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613384    OMIM disorders: --


    Find genes that share disorders with CCNL1           About GenesLikeMe

    2 Novoseek inferred disease relationships for CCNL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hnscc 57.2 2 15700036 (1), 16598186 (1)
    carcinoma squamous cell 28.7 3 16598186 (2), 15700036 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCNL1 (4 documents)

    Export disorders for CCNL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNL1 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with CCNL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclin L is an RS domain protein involved in pre-mRNA splicing. (PubMed id 11980906)1, 2, 3 Dickinson L.A.... Gottesfeld J.M. (J. Biol. Chem. 2002)
    2. Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer. (PubMed id 12414649)1, 2, 9 Redon R.... du Manoir S. (Cancer Res. 2002)
    3. Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC). (PubMed id 15700036)1, 2, 9 Sticht C.... Joos S. (Br. J. Cancer 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    8. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. (PubMed id 18216018)1, 9 Loyer P....Lahti J.M. (J. Biol. Chem. 2008)
    9. Characterization of cyclin L1 as an immobile component of the splicing factor compartment. (PubMed id 17494991)1, 9 Herrmann A....Becker W. (FASEB J. 2007)
    10. Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma. (PubMed id 16598186)1, 9 Muller D....Abecassis J. (Br. J. Cancer 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57018 HGNC: 20569 AceView: CCNL1 Ensembl:ENSG00000163660 euGenes: HUgn57018
    ECgene: CCNL1 H-InvDB: CCNL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNL1 gene:
    Search GeneIP for patents involving CCNL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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