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Aliases for CCNL1 Gene

Aliases for CCNL1 Gene

  • Cyclin L1 2 3
  • Cyclin-L 3 4
  • ANIA6A 3 6
  • Cyclin L Ania-6a 3
  • Cyclin L Gamma 3
  • Cyclin-L1 3
  • PRO1073 3
  • Ania-6a 3
  • BM-001 3

External Ids for CCNL1 Gene

Previous GeneCards Identifiers for CCNL1 Gene

  • GC03M157812
  • GC03M158147
  • GC03M158186
  • GC03M158348
  • GC03M156864
  • GC03M154261

Summaries for CCNL1 Gene

GeneCards Summary for CCNL1 Gene

CCNL1 (Cyclin L1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNT1.

UniProtKB/Swiss-Prot for CCNL1 Gene

  • Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.

Gene Wiki entry for CCNL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNL1 Gene

Genomics for CCNL1 Gene

Regulatory Elements for CCNL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNL1 Gene

Start:
157,146,364 bp from pter
End:
157,160,760 bp from pter
Size:
14,397 bases
Orientation:
Minus strand

Genomic View for CCNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNL1 Gene

Proteins for CCNL1 Gene

  • Protein details for CCNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK58-CCNL1_HUMAN
    Recommended name:
    Cyclin-L1
    Protein Accession:
    Q9UK58
    Secondary Accessions:
    • B3KMY3
    • Q6NVY9
    • Q6UWS7
    • Q8NI48
    • Q96QT0
    • Q9NZF3

    Protein attributes for CCNL1 Gene

    Size:
    526 amino acids
    Molecular mass:
    59634 Da
    Quaternary structure:
    • Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK11B, CDK12, CDK13 and SFRS2.
    Miscellaneous:
    • CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC
    SequenceCaution:
    • Sequence=AAF64257.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAQ89026.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNL1 Gene

Proteomics data for CCNL1 Gene at MOPED

Post-translational modifications for CCNL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNL1 Gene

Domains for CCNL1 Gene

Protein Domains for CCNL1 Gene

Suggested Antigen Peptide Sequences for CCNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK58

UniProtKB/Swiss-Prot:

CCNL1_HUMAN :
  • Q9UK58
Domain:
  • Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.
Family:
  • Belongs to the cyclin family. Cyclin L subfamily.
genes like me logo Genes that share domains with CCNL1: view

No data available for Gene Families for CCNL1 Gene

Function for CCNL1 Gene

Molecular function for CCNL1 Gene

GENATLAS Biochemistry: cyclin like 1,most likely member of a new family of cyclins,with homology to mouse cyclin G
UniProtKB/Swiss-Prot Function: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.

Gene Ontology (GO) - Molecular Function for CCNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNL1: view

Phenotypes for CCNL1 Gene

GenomeRNAi human phenotypes for CCNL1:
genes like me logo Genes that share phenotypes with CCNL1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCNL1 Gene

Localization for CCNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNL1 Gene

Nucleus speckle. Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNL1 Gene COMPARTMENTS Subcellular localization image for CCNL1 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17494991
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with CCNL1: view

Pathways for CCNL1 Gene

SuperPathways for CCNL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with CCNL1: view

No data available for Pathways by source for CCNL1 Gene

Transcripts for CCNL1 Gene

Unigene Clusters for CCNL1 Gene

Cyclin L1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CCNL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNL1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5:
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: - - - - -
SP10:
SP11: - -
SP12: - - -
SP13: - - -
SP14:
SP15: -
SP16: - - - -
SP17:
SP18: - - -

ExUns: 11d ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17: -
SP18:

Relevant External Links for CCNL1 Gene

GeneLoc Exon Structure for
CCNL1
ECgene alternative splicing isoforms for
CCNL1

Expression for CCNL1 Gene

mRNA expression in normal human tissues for CCNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNL1 Gene

SOURCE GeneReport for Unigene cluster for CCNL1 Gene Hs.4859

mRNA Expression by UniProt/SwissProt for CCNL1 Gene

Q9UK58-CCNL1_HUMAN
Tissue specificity: Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).
genes like me logo Genes that share expressions with CCNL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCNL1 Gene

Orthologs for CCNL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNL1 35
  • 99.81 (n)
  • 100 (a)
CCNL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNL1 35
  • 95.31 (n)
  • 98.48 (a)
CCNL1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNL1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnl1 35
  • 93.09 (n)
  • 98.15 (a)
Ccnl1 16
Ccnl1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNL1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNL1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnl1 35
  • 93.03 (n)
  • 97.34 (a)
chicken
(Gallus gallus)
Aves CCNL1 35
  • 81.77 (n)
  • 93.66 (a)
CCNL1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNL1 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13166 35
zebrafish
(Danio rerio)
Actinopterygii ccnl1a 35
  • 70.36 (n)
  • 82.75 (a)
ccnl1a 36
  • 76 (a)
OneToMany
ccnl1b 36
  • 66 (a)
OneToMany
Dr.28373 35
fruit fly
(Drosophila melanogaster)
Insecta CG16903 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyl-1 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN8 36
  • 20 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.1541 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11553 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for CCNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCNL1 Gene

ENSEMBL:
Gene Tree for CCNL1 (if available)
TreeFam:
Gene Tree for CCNL1 (if available)

Paralogs for CCNL1 Gene

Paralogs for CCNL1 Gene

Selected SIMAP similar genes for CCNL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCNL1: view

Variants for CCNL1 Gene

Sequence variations from dbSNP and Humsavar for CCNL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8925 -- 157,150,661(+) ATATA(C/T)TTCTG intron-variant, utr-variant-3-prime
rs3202590 -- 157,154,317(-) ATCTA(A/G)GAATG intron-variant
rs3202591 -- 157,154,260(-) AAGCC(C/T)AATTC intron-variant
rs4371471 -- 157,161,308(+) TTTCA(A/G)AAAGA upstream-variant-2KB
rs4680341 -- 157,151,413(+) AAGTG(C/T)TAAAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCNL1 Gene

Variant ID Type Subtype PubMed ID
nsv829766 CNV Gain 17160897
nsv520331 CNV Loss 19592680
nsv819788 CNV Loss 19587683
esv2660786 CNV Deletion 23128226

Relevant External Links for CCNL1 Gene

HapMap Linkage Disequilibrium report
CCNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNL1 Gene

Disorders for CCNL1 Gene

(2) Novoseek inferred disease relationships for CCNL1 Gene

Disease -log(P) Hits PubMed IDs
hnscc 57.2 2
carcinoma squamous cell 28.7 3

Relevant External Links for CCNL1

Human Genome Epidemiology (HuGE) Navigator
CCNL1
genes like me logo Genes that share disorders with CCNL1: view

No data available for UniProtKB/Swiss-Prot for CCNL1 Gene

Publications for CCNL1 Gene

  1. Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer. (PMID: 12414649) Redon R. … du Manoir S. (Cancer Res. 2002) 3 4 23
  2. Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC). (PMID: 15700036) Sticht C. … Joos S. (Br. J. Cancer 2005) 3 4 23
  3. Cyclin L is an RS domain protein involved in pre-mRNA splicing. (PMID: 11980906) Dickinson L.A. … Gottesfeld J.M. (J. Biol. Chem. 2002) 2 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CCNL1 Gene

Sources for CCNL1 Gene

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