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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNL1 Gene

protein-coding   GIFtS: 54
GCID: GC03M156864

cyclin L1
 Explore 8 diseases affiliated with
CCNL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCNL1    

Aliases
for CCNL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin L11 2     Cyclin L Gamma2
Ania-6a1     Cyclin-L3
ANIA6A2 5     Cyclin-L11
PRO10732     Cyclin-L3
Cyclin L Ania-6a2     

External Ids:    HGNC: 205691   Entrez Gene: 570182   Ensembl: ENSG000001636607   OMIM: 6133845   UniProtKB: Q9UK583   

Export aliases for CCNL1 gene to outside databases

Previous GC identifers: GC03M157812 GC03M158147 GC03M158186 GC03M158348 GC03M154261


Summaries
for CCNL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CCNL1_HUMAN, Q9UK58
Function: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be
involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases
(CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell
carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21

Gene Wiki entry for CCNL1


Genomic Views
for CCNL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNL1 gene promoter:
         AML1a   GCNF   FOXD1   FOXL1   GATA-2   AREB6   GCNF-1   FOXO1a   GCNF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.31   Ensembl cytogenetic band:  3q25.31   HGNC cytogenetic band: 3q25.31

CCNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNL1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M156864:  view genomic region     (about GC identifiers)

Start:
 156,864,297 bp from pter      End:
 156,878,549 bp from pter
Size:
 14,253 bases      Orientation:
 minus strand

Proteins
for CCNL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCNL1_HUMAN, Q9UK58 (See protein sequence)
Recommended Name: Cyclin-L1  
Size: 526 amino acids; 59634 Da
Subunit: Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with
CDK11A, CDK11B, CDK12, CDK13 and SFRS2
Subcellular location: Nucleus speckle (By similarity). Note=More specifically found in nuclear intrachromatin granules
clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA
processing (By similarity)
Miscellaneous: CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional
metastases and an unfavorable clinical outcome of HNSCC
Sequence caution: Sequence=AAF64257.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=AAQ89026.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: B3KMY3 Q6NVY9 Q6UWS7 Q8NI48 Q96QT0 Q9NZF3
Alternative splicing: 3 isoforms:  Q9UK58-1   Q9UK58-4   Q9UK58-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CCNL1: NX_Q9UK58

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UK58

    • CCNL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064703.1  
    ENSEMBL proteins: 
     ENSP00000420277   ENSP00000295926   ENSP00000417343   ENSP00000417237   ENSP00000417218  
     ENSP00000418449   ENSP00000418094   ENSP00000295925  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: CCNL1
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    Novus Biologicals CCNL1 Protein
    Novus Biologicals CCNL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CCNL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0016607nuclear speck IEA--


    CCNL1 for ontologies           About GeneDecksing



    CCNL1 Antibody Products: 
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    ThermoFisher Antibodies for CCNL1

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    Uscn ELISAs and CLIAs for CCNL1

    Protein Domains /
    Families
    for CCNL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCNL1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR017060 Cyclin_L
     IPR015429 Cyclin_C/H/T/L
     IPR015431 Cyclin_L_met/fun

    Graphical View of Domain Structure for InterPro Entry Q9UK58

    ProtoNet protein and cluster: Q9UK58

    1 Blocks protein family: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNL1_HUMAN, Q9UK58
    Domain: Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of
    the SR family of splicing factors. This region probably plays a role in protein-protein interactions
    Similarity: Belongs to the cyclin family. Cyclin L subfamily


    Function
    for CCNL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCNL1_HUMAN, Q9UK58
    Function: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be
    involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases
    (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell
    carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21

         Genatlas biochemistry entry for CCNL1:
    cyclin like 1,most likely member of a new family of cyclins,with homology to mouse cyclin G

    miRNA
    Products:            		miRTarBase miRNAs that target CCNL1:
    hsa-mir-18a (MIRT004383), hsa-mir-199a-5p (MIRT003963), hsa-mir-199b-3p (MIRT004397)

    OriGene 3'-UTR Clone: CCNL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNL1
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNL1 (see all 19):
    hsa-miR-4288 hsa-miR-3942-5p hsa-miR-346 hsa-miR-632 hsa-miR-548l hsa-miR-7-1* hsa-miR-199b-5p hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmid: CCNL1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNL1 (see all 7)
    OriGene shRNA RFP: CCNL1
    OriGene siRNA: CCNL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNL1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCNL1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNL1 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNL1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CCNL1
    Search LifeMap BioReagents cell lines for CCNL1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNL1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019901protein kinase binding IEA--


    CCNL1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CCNL1:
     Decreased viability 


    Pathways & Interactions
    for CCNL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCNL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/18 Interacting proteins for CCNL1 (Q9UK583 ENSP000002959264) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRSF2Q011303, ENSP000003508774I2D: score=1 STRING: ENSP00000350877
    CDK11AQ9UQ883, ENSP000003844424I2D: score=1 STRING: ENSP00000384442
    APPBP2Q926243I2D: score=1 
    MDFIQ997503I2D: score=1 
    MCM2ENSP000002650564STRING: ENSP00000265056
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein kinase activity IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006396RNA processing IEA--


    CCNL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCNL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNL1
    Search CenterWatch for drugs/clinical trials and news about CCNL1 

    Transcripts
    for CCNL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCNL1 gene: 
    NM_020307.2  

    Unigene Cluster for CCNL1:

    Cyclin L1
    Hs.4859  [show with all ESTs]
    Unigene Representative Sequence: BX641146
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000461804(uc003fbd.1 uc003fbi.1) ENST00000295926(uc003fbf.3)
    ENST00000464316(uc003fbe.3) ENST00000471247 ENST00000474539 ENST00000475298(uc003fbg.3 uc011bor.2)
    ENST00000476744 ENST00000470121 ENST00000468977 ENST00000467849 ENST00000476367
    ENST00000477127 ENST00000464679 ENST00000495471 ENST00000481173 ENST00000479052
    ENST00000483789 ENST00000478454

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CCNL1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNL1
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNL1 (see all 19):
    hsa-miR-4288 hsa-miR-3942-5p hsa-miR-346 hsa-miR-632 hsa-miR-548l hsa-miR-7-1* hsa-miR-199b-5p hsa-miR-591
    SwitchGear 3'UTR luciferase reporter plasmid: CCNL1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNL1 (see all 7)
    OriGene shRNA RFP: CCNL1
    OriGene siRNA: CCNL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNL1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNL1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNL1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCNL1 (NM_020307)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNL1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCNL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNL1

    Additional cDNA sequence: 

    AF180920.1 AF208843.1 AF367476.1 AF367477.1 AK022974.1 AK098021.1 AK122738.1 AK125606.1 
    AY034790.1 AY358663.1 BC007081.1 BC038394.1 BC067812.1 BX641146.1 BX647554.1 

    24/26 DOTS entries (see all 26):

    DT.442945  DT.99987197  DT.100664810  DT.91975143  DT.101981164  DT.100660246  DT.97817291  DT.99950023 
    DT.100892737  DT.97814388  DT.100837700  DT.100892717  DT.100711707  DT.100892735  DT.91772288  DT.101986367 
    DT.120881980  DT.95080806  DT.95080812  DT.100037644  DT.100773442  DT.120881984  DT.120881992  DT.91785442 

    24/377 AceView cDNA sequences (see all 377):

    AI434411 CB048746 AA828427 BM280390 AI762343 AF367477 CA398223 AI436633 
    AA908537 BQ180877 BU070642 AI952711 AW440957 BC067812 BX642239 AW575633 
    AA479780 BC007081 AA826520 AA328216 AI969491 BQ719728 AW150124 AA152106 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CCNL1 (see all 18)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ·
    SP1:                          -                 -     -     -                       -                 -     -                 -                                 
    SP2:                          -                 -           -                       -                 -     -           -     -                                 
    SP3:                          -                 -     -     -                       -                 -     -     -     -     -                                 
    SP4:                          -                 -     -     -                       -                 -     -     -     -     -                                 
    SP5:                                                                                                                                                            

    ExUns: 11d ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
    SP1:  -           -           -                           
    SP2:  -           -           -                           
    SP3:  -           -           -                           
    SP4:  -           -           -     -     -     -         
    SP5:  -           -           -                           


    ECgene alternative splicing isoforms for CCNL1

    Expression
    for CCNL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTAAAGATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CCNL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNL1

    SOURCE GeneReport for Unigene cluster: Hs.4859

    UniProtKB/Swiss-Prot: CCNL1_HUMAN, Q9UK58
    Tissue specificity: Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous
    cell carcinomas (HNSCC)

        SABiosciences Custom PCR Arrays for CCNL1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNL1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNL1

    Orthologs
    for CCNL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNL1 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCNL11 cyclin L1 81.77(n)
    93.66(a)    		   425024  XM_422826.3  XP_422826.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CCNL16
    		 --
    		 87(a)
    		 1 ↔ 1
    		 3(15023163-15038123)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BU914792.12   -- 79.89(n)    BU914792.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.283732 Danio rerio cDNA clone IMAGE6790900, partial cds 74.18(n)    BC057418.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG169031 CG16903 48.76(n)
    49.3(a)    		   31178  NM_130624.2  NP_569980.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea cyl-11 Protein CYL-1 49.74(n)
    44.18(a)    		   179643  NM_073606.2  NP_506007.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RCY11 cyclin-L1-1 47.57(n)
    38.77(a)    		   817183  NM_128200.4  NP_565622.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.15412 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.56(n)    AK069233.1 


    ENSEMBL Gene Tree for CCNL1 (if available)
    TreeFam Gene Tree for CCNL1 (if available) 

    Paralogs
    for CCNL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNL1 gene
    CCNT22  CCNL22  CCNK2  CCNC2  CCNT12  FAM58A2  
    2 SIMAP similar genes for CCNL1 using alignment to 3 protein entries:     CCNL1_HUMAN (see all proteins):
    CCNL2    FAM58A

    CCNL1 for paralogs           About GeneDecksing



    Genomic Variants
    for CCNL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/243 NCBI SNPs in CCNL1 are shown (see all 243)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1927735421,2
    		--156865096(+) ATTCCA/GGCTTT 1 -- ds50010--------
    rs1854975401,2
    		--156865264(+) ATTCAA/TTAGGG 1 -- ds50010--------
    rs67714651,2
    		C,F,H,--156865338(+) CAAATC/GAGGTT 1 -- ds50016Minor allele frequency- G:0.09NS EA WA 538
    rs1907984601,2
    		--156865369(+) ATAACA/CTTTAA 1 -- ds50010--------
    rs1427558741,2
    		--156865390(+) TTGGGC/TGACTC 1 -- ds50010--------
    rs1510348581,2
    		--156865499(+) AAAGAA/GTAAGT 1 -- ds50010--------
    rs1817134931,2
    		--156865640(+) ATGCAC/GACAAA 1 -- ut310--------
    rs115462461,2
    		C,H--156865800(+) AAGTAC/TAATTG 1 -- ut312Minor allele frequency- T:0.01NS NA 174
    rs1843556781,2
    		--156865947(+) TTTGCA/GTTTAA 1 -- ut310--------
    rs1181448371,2
    		C,F,--156865958(+) TGTTTT/CTGATT 1 -- ut311Minor allele frequency- C:0.04EA 120

    HapMap Linkage Disequilibrium report for CCNL1 (156864297 - 156878549 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CCNL1
         2 CNVs: 59102 50973

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    Disorders / Diseases
    for CCNL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCNL1 for disorders           About GeneDecksing

    OMIM gene information: 613384    OMIM disorders: --

    8 diseases for CCNL1:    About MalaCards
    squamous cell carcinoma    pandas    hepatocellular carcinoma    carcinoma
    breast cancer    cervicitis    malaria    neuronitis

    2 Novoseek disease relationships for CCNL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hnscc 57.2 2 15700036 (1), 16598186 (1)
    carcinoma squamous cell 28.7 3 16598186 (2), 15700036 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCNL1 (4 documents)

    Export disorders for CCNL1 gene to outside databases

    Publications
    for CCNL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNL1 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with CCNL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclin L is an RS domain protein involved in pre-mRNA splicing. (PubMed id 11980906)1, 2, 3 Dickinson L.A.... Gottesfeld J.M. (2002)
    2. Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer. (PubMed id 12414649)1, 2, 9 Redon R.... du Manoir S. (2002)
    3. Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC). (PubMed id 15700036)1, 2, 9 Sticht C.... Joos S. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    8. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. (PubMed id 18216018)1, 9 Loyer P....Lahti J.M. (2008)
    9. Characterization of cyclin L1 as an immobile component of the splicing factor compartment. (PubMed id 17494991)1, 9 Herrmann A....Becker W. (2007)
    10. Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma. (PubMed id 16598186)1, 9 Muller D....Abecassis J. (2006)

    External Searches for CCNL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCNL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57018 HGNC: 20569 AceView: CCNL1 Ensembl:ENSG00000163660 euGenes: HUgn57018
    ECgene: CCNL1 H-InvDB: CCNL1

    Other Databases showing CCNL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCNL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CCNL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCNL1 gene:
    Search GeneIP for patents involving CCNL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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