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Aliases for CCNK Gene

Aliases for CCNK Gene

  • Cyclin K 2 3
  • CPR4 3 4
  • Cyclin-K 3

External Ids for CCNK Gene

Previous GeneCards Identifiers for CCNK Gene

  • GC14P097459
  • GC14P093763
  • GC14P097937
  • GC14P097949
  • GC14P099017
  • GC14P099947
  • GC14P080131

Summaries for CCNK Gene

Entrez Gene Summary for CCNK Gene

  • The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNK Gene

CCNK (Cyclin K) is a Protein Coding gene. Diseases associated with CCNK include pthirus pubis infestation and kaposi sarcoma. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include protein kinase binding and RNA polymerase II carboxy-terminal domain kinase activity. An important paralog of this gene is CCNT1.

UniProtKB/Swiss-Prot for CCNK Gene

  • Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

Gene Wiki entry for CCNK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNK Gene

Genomics for CCNK Gene

Regulatory Elements for CCNK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNK Gene

Start:
99,481,169 bp from pter
End:
99,535,044 bp from pter
Size:
53,876 bases
Orientation:
Plus strand

Genomic View for CCNK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNK Gene

Proteins for CCNK Gene

  • Protein details for CCNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75909-CCNK_HUMAN
    Recommended name:
    Cyclin-K
    Protein Accession:
    O75909
    Secondary Accessions:
    • Q59FT6
    • Q86U16
    • Q96B63
    • Q9NNY9

    Protein attributes for CCNK Gene

    Size:
    580 amino acids
    Molecular mass:
    64240 Da
    Quaternary structure:
    • Regulatory subunit of cyclin-dependent kinases. Identified in a complex with a kinase and the RNA polymerase II holoenzyme. Interacts with POLR2A. Interacts with CDK12 and CDK13. Interacts with CDK9 according to PubMed:10574912; does not interact with CDK9 according to PubMed:22012619.

    Three dimensional structures from OCA and Proteopedia for CCNK Gene

    Alternative splice isoforms for CCNK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNK Gene

Proteomics data for CCNK Gene at MOPED

Post-translational modifications for CCNK Gene

  • Ubiquitination at Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNK Gene

No data available for DME Specific Peptides for CCNK Gene

Domains for CCNK Gene

Protein Domains for CCNK Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75909

UniProtKB/Swiss-Prot:

CCNK_HUMAN :
  • O75909
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.
genes like me logo Genes that share domains with CCNK: view

No data available for Gene Families for CCNK Gene

Function for CCNK Gene

Molecular function for CCNK Gene

GENATLAS Biochemistry: cyclin K,RNA polymerase II associated cyclin,ubiquitously expressed but most abundant in developing germ cells of adult testis and ovary,likely involved in the regulation of basal transcription
UniProtKB/Swiss-Prot Function: Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

Gene Ontology (GO) - Molecular Function for CCNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IDA 9632813
GO:0005515 protein binding IPI 16189514
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA 9632813
GO:0019901 protein kinase binding IPI 22012619
genes like me logo Genes that share ontologies with CCNK: view
genes like me logo Genes that share phenotypes with CCNK: view

Animal Model Products

miRNA for CCNK Gene

miRTarBase miRNAs that target CCNK

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNK

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCNK Gene

Localization for CCNK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNK Gene COMPARTMENTS Subcellular localization image for CCNK gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002944 cyclin K-CDK12 complex IPI 22012619
GO:0002945 cyclin K-CDK13 complex IPI 22012619
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CCNK: view

Pathways for CCNK Gene

SuperPathways for CCNK Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with CCNK: view

Pathways by source for CCNK Gene

1 BioSystems pathway for CCNK Gene

Gene Ontology (GO) - Biological Process for CCNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9632813
GO:0006468 protein phosphorylation IDA 9632813
genes like me logo Genes that share ontologies with CCNK: view

Transcripts for CCNK Gene

Unigene Clusters for CCNK Gene

Cyclin K:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNK Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6: - -

Relevant External Links for CCNK Gene

GeneLoc Exon Structure for
CCNK
ECgene alternative splicing isoforms for
CCNK

Expression for CCNK Gene

mRNA expression in normal human tissues for CCNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNK Gene

SOURCE GeneReport for Unigene cluster for CCNK Gene Hs.510409

mRNA Expression by UniProt/SwissProt for CCNK Gene

O75909-CCNK_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels in testis.
genes like me logo Genes that share expressions with CCNK: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCNK Gene

Orthologs for CCNK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNK 35
  • 99.77 (n)
  • 100 (a)
CCNK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNK 35
  • 90.06 (n)
  • 95.52 (a)
CCNK 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNK 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnk 35
  • 88.45 (n)
  • 95 (a)
Ccnk 16
Ccnk 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNK 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNK 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnk 35
  • 87.76 (n)
  • 95 (a)
chicken
(Gallus gallus)
Aves CCNK 35
  • 78.87 (n)
  • 89.54 (a)
CCNK 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNK 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4340 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnk 35
  • 73.77 (n)
  • 81.24 (a)
zebrafish
(Danio rerio)
Actinopterygii ccnk 35
  • 68.98 (n)
  • 75.34 (a)
ccnk 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycK 36
  • 55 (a)
OneToOne
CycK 37
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea ccnk-1 36
  • 40 (a)
OneToOne
F43D2.1 37
  • 39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pch1 35
  • 46.52 (n)
  • 37.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8802 36
  • 70 (a)
OneToOne
Species with no ortholog for CCNK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNK Gene

ENSEMBL:
Gene Tree for CCNK (if available)
TreeFam:
Gene Tree for CCNK (if available)

Paralogs for CCNK Gene

Paralogs for CCNK Gene

Selected SIMAP similar genes for CCNK Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCNK: view

Variants for CCNK Gene

Sequence variations from dbSNP and Humsavar for CCNK Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs941547 -- 99,506,038(-) CACAC(A/T)CTACC intron-variant
rs941548 -- 99,504,943(-) ACTTA(C/T)TGCTC intron-variant
rs2069483 -- 99,492,203(+) AGATG(C/G)TTAGT intron-variant
rs2069484 -- 99,492,710(+) CCTTC(A/G)GTAAC reference, synonymous-codon
rs2069485 -- 99,493,400(+) TAATA(C/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNK Gene

Variant ID Type Subtype PubMed ID
esv997017 OTHER Inversion 20482838
dgv1977n71 CNV Loss 21882294

Relevant External Links for CCNK Gene

HapMap Linkage Disequilibrium report
CCNK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNK Gene

Disorders for CCNK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CCNK Gene including...

Search for CCNK Gene in MalaCards »

(1) University of Copenhagen DISEASES for CCNK Gene

(4) Novoseek inferred disease relationships for CCNK Gene

Disease -log(P) Hits PubMed IDs
kaposi sarcoma 46.3 2
lymphoma 17.1 2
tumors 0 2
cancer 0 1

Relevant External Links for CCNK

Genetic Association Database (GAD)
CCNK
Human Genome Epidemiology (HuGE) Navigator
CCNK
genes like me logo Genes that share disorders with CCNK: view

No data available for UniProtKB/Swiss-Prot for CCNK Gene

Publications for CCNK Gene

  1. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. (PMID: 9632813) Edwards M.C. … Elledge S.J. (Mol. Cell. Biol. 1998) 2 3 4 23
  2. Crystal structure of human cyclin K, a positive regulator of cyclin- dependent kinase 9. (PMID: 17169370) Baek K. … Ladias J.A. (J. Mol. Biol. 2007) 3 4 23
  3. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. (PMID: 10574912) Fu T.J. … Flores O. (J. Biol. Chem. 1999) 2 3 4
  4. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. (PMID: 11884399) Lin X. … Peterlin B.M. (J. Biol. Chem. 2002) 3 23
  5. Cyclin K as a direct transcriptional target of the p53 tumor suppressor. (PMID: 11988847) Mori T. … Arakawa H. (Neoplasia 2002) 3 23

Products for CCNK Gene

Sources for CCNK Gene

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