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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNK Gene

protein-coding   GIFtS: 59
GCID: GC14P099947

Cyclin K

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin K1 2
CPR42 3
cyclin-K2

External Ids:    HGNC: 15961   Entrez Gene: 88122   Ensembl: ENSG000000900617   OMIM: 6035445   UniProtKB: O759093   

Export aliases for CCNK gene to outside databases

Previous GC identifers: GC14P097459 GC14P093763 GC14P097937 GC14P097949 GC14P099017 GC14P080131


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNK Gene:
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate
transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate
the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in
regulating CDK and RNA polymerase II activities. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNK Gene: 
CCNK (cyclin K) is a protein-coding gene. Diseases associated with CCNK include kaposi's sarcoma, and pthirus pubis infestation. GO annotations related to this gene include RNA polymerase II carboxy-terminal domain kinase activity and protein kinase binding. An important paralog of this gene is CCNL2.

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
Function: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward
both RNA polymerase II C-terminal domain and CDK2 (CAK)

Gene Wiki entry for CCNK (Cyclin K) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNK gene promoter:
         MAZR   p53   FOXD1   CUTL1   POU6F1 (c2)   FOXO4   STAT3   NF-Y   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNK promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32

CCNK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNK gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P099947:  view genomic region     (about GC identifiers)

Start:
99,947,506 bp from pter      End:
100,001,381 bp from pter
Size:
53,876 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909 (See protein sequence)
Recommended Name: Cyclin-K  
Size: 580 amino acids; 64240 Da
Subunit: Part of a cyclin-kinase pair in the RNA polymerase II holoenzyme. Binds to CDK9
1 PDB 3D structure from and Proteopedia for CCNK:
2I53 (3D)    
Secondary accessions: Q59FT6 Q86U16 Q96B63 Q9NNY9
Alternative splicing: 4 isoforms:  O75909-3   O75909-2   O75909-1   O75909-4   

Explore the universe of human proteins at neXtProt for CCNK: NX_O75909

Explore proteomics data for CCNK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75909

  • CCNK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNK Protein Expression
    REFSEQ proteins: NP_001092872.1  
    ENSEMBL proteins: 
     ENSP00000374529   ENSP00000450792   ENSP00000452307   ENSP00000450440  

    Human Recombinant Protein Products for CCNK: 
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    Novus Biologicals CCNK Protein
    Novus Biologicals CCNK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNK 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002944cyclin K-CDK12 complex IPI--
    GO:0002945cyclin K-CDK13 complex IPI--

    CCNK for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR015429 Cyclin_C/H/T/L

    Graphical View of Domain Structure for InterPro Entry O75909

    ProtoNet protein and cluster: O75909

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    CCNK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNK_HUMAN, O75909
    Function: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward
    both RNA polymerase II C-terminal domain and CDK2 (CAK)

         Genatlas biochemistry entry for CCNK:
    cyclin K,RNA polymerase II associated cyclin,ubiquitously expressed but most abundant in developing germ cells of
    adult testis and ovary,likely involved in the regulation of basal transcription

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IDA9632813
    GO:0005515protein binding IPI16713569
    GO:0008353RNA polymerase II carboxy-terminal domain kinase activity IDA9632813
    GO:0019901protein kinase binding IPI--
         
    CCNK for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CCNK:
     Decreased Hepatitis C virus re  Decreased POU5F1-GFP protein e  Decreased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ccnk):
     mortality/aging 

    CCNK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNK 

    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNK (see all 33):
    hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-30d hsa-miR-624 hsa-miR-30a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCCNK 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of CCNK 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCNK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for CCNK
        Direct p53 effectors


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for CCNK (O759091, 2, 3 ENSP000003745294) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-739806,EBI-930964 MINT-2865482 MINT-2855089 I2D: score=3 STRING: ENSP00000244769
    CCDC85BQ158342, 3, ENSP000003116954MINT-66150 I2D: score=5 STRING: ENSP00000311695
    HMG20AQ9NP662, 3, ENSP000003368564MINT-68052 I2D: score=5 STRING: ENSP00000336856
    RBPMSQ930622, 3, ENSP000003401764MINT-66934 I2D: score=5 STRING: ENSP00000340176
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-67823 I2D: score=5 STRING: ENSP00000360441
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS9632813
    GO:0006974response to DNA damage stimulus IMP--

    CCNK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNK

    Search CenterWatch for drugs/clinical trials and news about CCNK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNK gene (2 alternative transcripts): 
    NM_001099402.1  NM_003858.3  

    Unigene Cluster for CCNK:

    Cyclin K
    Hs.510409  [show with all ESTs]
    Unigene Representative Sequence: AB209373
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557165 ENST00000389879(uc001ygi.4) ENST00000553636 ENST00000557441
    ENST00000555049 ENST00000555842 ENST00000556641 ENST00000555942 ENST00000553865

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNK (see all 33):
    hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-30d hsa-miR-624 hsa-miR-30a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCCNK 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNK
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    Additional mRNA sequence: 

    AB209373.1 AK000799.1 AK124466.1 AK311075.1 BC015935.1 BT006950.1 BX247958.1 

    13 DOTS entries:

    DT.215479  DT.95098492  DT.100723022  DT.100812855  DT.40192993  DT.86999816  DT.91946474  DT.102830769 
    DT.91990905  DT.120780549  DT.92445866  DT.95093600  DT.95150722 

    24/175 AceView cDNA sequences (see all 175):

    CA398104 CF541374 BU171093 BF725949 NM_003858 BX247958 BM504212 AA298483 
    BM465940 BM717996 BC015935 BM508958 AI916400 BM505592 AW450108 CA398105 
    CD365522 AI001776 CD722655 W74357 AA417379 AA421192 BU168392 AW189612 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CCNK (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                -                                                               
    SP2:              -     -           -                                                               
    SP3:                    -           -                                                               
    SP4:              -                 -                                                               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CCNK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACCCAGAA
    CCNK Expression
    About this image


    See CCNK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNK

    SOURCE GeneReport for Unigene cluster: Hs.510409

    UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
    Tissue specificity: Ubiquitously expressed. Highest levels in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCNK gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnk1 , 5 cyclin K1, 5 89.6(n)1
    96.21(a)1
      12 (59.23 cM)5
    124541  NM_009832.21  NP_033962.21 
     1081797385 
    chicken
    (Gallus gallus)
    Aves CCNK1 cyclin K 79.15(n)
    91.51(a)
      423446  NM_001031209.1  NP_001026380.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNK6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343270.1(1816456-1832354)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.43402 Xenopus laevis transcribed sequence with strong similarity to protein spO75909 (H.sapiens) CYCK_HUMAN Cyclin K less 80.72(n)    CA791066.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnk1 cyclin K 68.97(n)
    76.45(a)
      569432  NM_001163779.1  NP_001157251.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycK1 , 3 cyclin-dependent protein kinase,
    regulator3
    Cyclin K1
    63(a)3
    54.01(n)1
    53.93(a)1
      40E43
    498161  NM_176068.31  NP_788082.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F43D2.13
    CELE_F43D2.11
    G1/S-specfic cyclin C like3
    Protein F43D2.11
    39(a)3
    50.35(n)1
    42.13(a)1
      V(14615155-14616187)3
    1857041  NM_074214.21  NP_506615.21 


    ENSEMBL Gene Tree for CCNK (if available)
    TreeFam Gene Tree for CCNK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNK gene
    CCNL22  CCNT22  CCNC2  CCNL12  FAM58A2  CCNT12  
    3 SIMAP similar genes for CCNK using alignment to 4 protein entries:     CCNK_HUMAN (see all proteins):
    CYCT1b    CCNT2    FAM58A

    CCNK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/559 SNPs in CCNK are shown (see all 559)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890570531,2
    --99949245(+) TTCTTA/TAAAAT 1 -- int10--------
    rs1419984421,2
    --99949254(+) ATTGGA/GTAAGG 1 -- int10--------
    rs1462436311,2
    C--99949358(+) TTGCAA/GATGAC 1 -- int10--------
    rs80151371,2
    H--99949402(+) TCCTAA/GAAGTA 1 -- int14Minor allele frequency- G:0.00NS EA 408
    rs1932678421,2
    --99949451(+) TTTTCA/GCATAG 1 -- int10--------
    rs1391302191,2
    C--99949452(+) TTTCAC/GATAGA 1 -- int10--------
    rs80153041,2
    C,F,A--99949522(+) GGAAGA/GGCCAA 1 -- int18Minor allele frequency- G:0.46NA WA EA 368
    rs1848423821,2
    --99949751(+) CAGATA/GTGGAG 1 -- int10--------
    rs786204581,2
    C,F--99949883(+) CCCTGT/ACTCAA 1 -- int12Minor allele frequency- A:0.15CSA WA 120
    rs1891874791,2
    --99949950(+) GGTGAC/TTGGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCNK (99947506 - 100001381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCNK:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1977n71CNV Loss21882294
    esv997017OTHER Inversion20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603544    OMIM disorders: --

    9 diseases for CCNK:    About MalaCards
    kaposi's sarcoma    pthirus pubis infestation    fanconi's anemia    sarcoma
    anemia    neuroblastoma    myeloma    endotheliitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CCNK:
    Pthirus pubis infestation

    CCNK for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CCNK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kaposi sarcoma 46.3 2 15870436 (1), 15144954 (1)
    lymphoma 17.1 2 20331971 (1), 16115893 (1)
    tumors 0 2 12743275 (1), 11988847 (1)
    cancer 0 1 16552186 (1)

    Genetic Association Database (GAD): CCNK
    Human Genome Epidemiology (HuGE) Navigator: CCNK (1 document)

    Export disorders for CCNK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNK gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with CCNK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. (PubMed id 9632813)1, 2, 3, 9 Edwards M.C.... Elledge S.J. (1998)
    2. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. (PubMed id 10574912)1, 2, 3 Fu T.J.... Flores O. (1999)
    3. Crystal structure of human cyclin K, a positive regulator of cyclin- dependent kinase 9. (PubMed id 17169370)1, 2, 9 Baek K.... Ladias J.A. (2007)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Cyclin K as a direct transcriptional target of the p53 tumor suppressor. (PubMed id 11988847)1, 9 Mori T....Arakawa H. (2002)
    7. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. (PubMed id 11884399)1, 9 Lin X....Peterlin B.M. (2002)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8812 HGNC: 1596 AceView: CCNK Ensembl:ENSG00000090061 euGenes: HUgn8812
    ECgene: CCNK H-InvDB: CCNK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNK Genetics and Cytogenetics in Oncology and Haematology
    NIEHS SNPshttp://egp.gs.washington.edu/data/ccnk/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNK gene:
    Search GeneIP for patents involving CCNK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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