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Aliases for CCNK Gene

Aliases for CCNK Gene

  • Cyclin K 2 3 5
  • CPR4 3 4
  • Cyclin-K 3

External Ids for CCNK Gene

Previous GeneCards Identifiers for CCNK Gene

  • GC14P097459
  • GC14P093763
  • GC14P097937
  • GC14P097949
  • GC14P099017
  • GC14P099947
  • GC14P080131

Summaries for CCNK Gene

Entrez Gene Summary for CCNK Gene

  • The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNK Gene

CCNK (Cyclin K) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle. GO annotations related to this gene include protein kinase binding and RNA polymerase II carboxy-terminal domain kinase activity. An important paralog of this gene is CCNT1.

UniProtKB/Swiss-Prot for CCNK Gene

  • Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

Gene Wiki entry for CCNK Gene

Additional gene information for CCNK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNK Gene

Genomics for CCNK Gene

Regulatory Elements for CCNK Gene

Enhancers for CCNK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H099225 2.7 FANTOM5 Ensembl ENCODE dbSUPER 24.2 -249.9 -249889 11.4 HDGF PKNOX1 INSM2 YBX1 FEZF1 BATF ZNF2 GLIS2 ZNF366 ZSCAN5C CCNK BCL11B ENSG00000234648 RPL3P4 SETD3 GC14M099237 GC14M099236 GC14P099215
GH14H099255 3 FANTOM5 Ensembl ENCODE dbSUPER 20.2 -215.9 -215850 19.8 PKNOX1 SIN3A FEZF1 ZNF2 ZBTB7B ZNF207 ZNF143 DEK SP3 REST BCL11B RPL3P4 CCNK ENSG00000234648 ENSG00000235785
GH14H100236 1.4 ENCODE dbSUPER 34.3 +758.3 758299 5.8 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 CCNK RN7SL523P ENSG00000258560 ENSG00000258672 ENSG00000258383 ENSG00000247970 YY1 WDR25 RPS2P3 SLC25A29
GH14H099560 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 14.6 +87.8 87838 18 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 CCDC85C CCNK ENSG00000234648 ENSG00000247970 HHIPL1 RPL3P4 EML1 SETD3 GC14P099584 GC14M099518
GH14H100304 1.2 ENCODE dbSUPER 23.6 +824.9 824938 3.6 SIN3A ZBTB7B GLIS2 ELK1 ZNF143 ZNF207 SP3 SP5 NFYC GLIS1 CCNK SLC25A29 YY1 MEG3 ENSG00000259052
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNK on UCSC Golden Path with GeneCards custom track

Promoters for CCNK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000072951 -169 3201 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Locations for CCNK Gene

Genomic Locations for CCNK Gene
chr14:99,481,169-99,535,044
(GRCh38/hg38)
Size:
53,876 bases
Orientation:
Plus strand
chr14:99,947,506-100,001,381
(GRCh37/hg19)

Genomic View for CCNK Gene

Genes around CCNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNK Gene

Proteins for CCNK Gene

  • Protein details for CCNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75909-CCNK_HUMAN
    Recommended name:
    Cyclin-K
    Protein Accession:
    O75909
    Secondary Accessions:
    • Q59FT6
    • Q86U16
    • Q96B63
    • Q9NNY9

    Protein attributes for CCNK Gene

    Size:
    580 amino acids
    Molecular mass:
    64240 Da
    Quaternary structure:
    • Regulatory subunit of cyclin-dependent kinases. Identified in a complex with a kinase and the RNA polymerase II holoenzyme. Interacts with POLR2A. Interacts with CDK12 and CDK13. Interacts with CDK9 according to PubMed:10574912; does not interact with CDK9 according to PubMed:22012619.

    Three dimensional structures from OCA and Proteopedia for CCNK Gene

    Alternative splice isoforms for CCNK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNK Gene

Post-translational modifications for CCNK Gene

  • Ubiquitination at posLast=166166
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNK Gene

No data available for DME Specific Peptides for CCNK Gene

Domains & Families for CCNK Gene

Gene Families for CCNK Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNK Gene

Suggested Antigen Peptide Sequences for CCNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75909

UniProtKB/Swiss-Prot:

CCNK_HUMAN :
  • Belongs to the cyclin family. Cyclin C subfamily.
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.
genes like me logo Genes that share domains with CCNK: view

Function for CCNK Gene

Molecular function for CCNK Gene

GENATLAS Biochemistry:
cyclin K,RNA polymerase II associated cyclin,ubiquitously expressed but most abundant in developing germ cells of adult testis and ovary,likely involved in the regulation of basal transcription
UniProtKB/Swiss-Prot Function:
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

Phenotypes From GWAS Catalog for CCNK Gene

Gene Ontology (GO) - Molecular Function for CCNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IDA 9632813
GO:0005515 protein binding IPI 16189514
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA 9632813
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA --
genes like me logo Genes that share ontologies with CCNK: view
genes like me logo Genes that share phenotypes with CCNK: view

Clone Products

  • Addgene plasmids for CCNK

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNK Gene

Localization for CCNK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNK gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002944 cyclin K-CDK12 complex IPI 22012619
GO:0002945 cyclin K-CDK13 complex IPI 22012619
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with CCNK: view

Pathways & Interactions for CCNK Gene

genes like me logo Genes that share pathways with CCNK: view

Pathways by source for CCNK Gene

Gene Ontology (GO) - Biological Process for CCNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9632813
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with CCNK: view

No data available for SIGNOR curated interactions for CCNK Gene

Drugs & Compounds for CCNK Gene

No Compound Related Data Available

Transcripts for CCNK Gene

Unigene Clusters for CCNK Gene

Cyclin K:
Representative Sequences:

Clone Products

  • Addgene plasmids for CCNK

Alternative Splicing Database (ASD) splice patterns (SP) for CCNK Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6: - -

Relevant External Links for CCNK Gene

GeneLoc Exon Structure for
CCNK
ECgene alternative splicing isoforms for
CCNK

Expression for CCNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNK Gene

This gene is overexpressed in Lymph node (16.2), Lung (10.6), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCNK Gene



Protein tissue co-expression partners for CCNK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNK Gene:

CCNK

SOURCE GeneReport for Unigene cluster for CCNK Gene:

Hs.510409

mRNA Expression by UniProt/SwissProt for CCNK Gene:

O75909-CCNK_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels in testis.

Evidence on tissue expression from TISSUES for CCNK Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Blood(4.1)
  • Intestine(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with CCNK: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNK Gene

Orthologs for CCNK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNK 33 34
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia CCNK 33 34
  • 90.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNK 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnk 33 16 34
  • 88.45 (n)
rat
(Rattus norvegicus)
Mammalia Ccnk 33
  • 87.76 (n)
dog
(Canis familiaris)
Mammalia CCNK 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNK 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNK 33 34
  • 78.87 (n)
lizard
(Anolis carolinensis)
Reptilia CCNK 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnk 33
  • 73.77 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4340 33
zebrafish
(Danio rerio)
Actinopterygii ccnk 33 34
  • 68.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CycK 35 34
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea ccnk-1 34
  • 40 (a)
OneToOne
F43D2.1 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8802 34
  • 70 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pch1 33
  • 46.52 (n)
Species where no ortholog for CCNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNK Gene

ENSEMBL:
Gene Tree for CCNK (if available)
TreeFam:
Gene Tree for CCNK (if available)

Paralogs for CCNK Gene

Paralogs for CCNK Gene

(3) SIMAP similar genes for CCNK Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCNK: view

Variants for CCNK Gene

Sequence variations from dbSNP and Humsavar for CCNK Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000002771 -- 99,508,730(+) TTGCT(C/G)TTCCA intron-variant
rs1000051674 -- 99,508,549(+) GGCGC(A/G)GTAAA intron-variant
rs1000090247 -- 99,498,027(+) CATGC(C/T)GTGGT intron-variant
rs1000318344 -- 99,504,745(+) GTGCC(C/T)AGCCT intron-variant
rs1000363308 -- 99,496,187(+) GTGTT(C/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNK Gene

Variant ID Type Subtype PubMed ID
nsv952236 CNV deletion 24416366
esv997017 OTHER inversion 20482838
esv3635481 CNV gain 21293372

Variation tolerance for CCNK Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNK Gene

Disorders for CCNK Gene

Relevant External Links for CCNK

Genetic Association Database (GAD)
CCNK
Human Genome Epidemiology (HuGE) Navigator
CCNK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNK

No disorders were found for CCNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNK Gene

Publications for CCNK Gene

  1. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. (PMID: 9632813) Edwards MC … Elledge SJ (Molecular and cellular biology 1998) 2 3 4 22 60
  2. Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9. (PMID: 17169370) Baek K … Ladias JA (Journal of molecular biology 2007) 3 4 22 60
  3. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. (PMID: 10574912) Fu TJ … Flores O (The Journal of biological chemistry 1999) 2 3 4 60
  4. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. (PMID: 22012619) Blazek D … Peterlin BM (Genes & development 2011) 3 4 60
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60

Products for CCNK Gene

  • Addgene plasmids for CCNK

Sources for CCNK Gene

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