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Aliases for CCNK Gene

Aliases for CCNK Gene

  • Cyclin K 2 3 5
  • CPR4 3 4
  • Cyclin-K 3

External Ids for CCNK Gene

Previous GeneCards Identifiers for CCNK Gene

  • GC14P097459
  • GC14P093763
  • GC14P097937
  • GC14P097949
  • GC14P099017
  • GC14P099947
  • GC14P080131

Summaries for CCNK Gene

Entrez Gene Summary for CCNK Gene

  • The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNK Gene

CCNK (Cyclin K) is a Protein Coding gene. Diseases associated with CCNK include Kaposi Sarcoma. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and HIV Life Cycle. GO annotations related to this gene include protein kinase binding and RNA polymerase II carboxy-terminal domain kinase activity. An important paralog of this gene is CCNT1.

UniProtKB/Swiss-Prot for CCNK Gene

  • Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

Gene Wiki entry for CCNK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNK Gene

Genomics for CCNK Gene

Regulatory Elements for CCNK Gene

Enhancers for CCNK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G099435 0.9 Ensembl ENCODE 15.6 -44.2 -44187 2.3 RFX1 SAP130 MAX ZBTB7B YY1 NR2F2 ZFHX2 JUND ZSCAN5C MAFK SETD3 CCNK GC14P099446 ENSG00000258383
GH14G099411 0.8 ENCODE 14.8 -68.3 -68333 2.2 TEAD4 INSM2 FEZF1 ZNF316 ZFHX2 ZNF366 GLI2 SCRT2 SMC3 FOS CCNK SETD3 GC14P099446 ENSG00000258383
GH14G099502 1 ENCODE dbSUPER 11.3 +22.2 22168 2.0 CTCF SIN3A RBBP5 ZBTB7B CTBP1 POLR2A ZSCAN5C FOS RFX1 RNF2 SETD3 CCNK ENSG00000247970 CCDC85C GC14M099501 ENSG00000258749
GH14G099415 1 Ensembl ENCODE 10.2 -65.4 -65369 0.4 ELF3 CTCF PKNOX1 ZNF384 RAD21 ZNF143 SMC3 ZNF391 ZNF362 ZNF654 SETD3 CCNK GC14P099446 ENSG00000258383
GH14G099459 0.7 ENCODE 11.4 -20.4 -20444 1.8 CTCF ATF1 CBX3 ZBTB7A ZKSCAN1 ARID1B ZFHX2 GATA3 EGR1 HMBOX1 SETD3 CCNK RNU6-91P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNK on UCSC Golden Path with GeneCards custom track

Promoters for CCNK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000072951 -169 3201 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for CCNK Gene

Chromosome:
14
Start:
99,481,169 bp from pter
End:
99,535,044 bp from pter
Size:
53,876 bases
Orientation:
Plus strand

Genomic View for CCNK Gene

Genes around CCNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNK Gene

Proteins for CCNK Gene

  • Protein details for CCNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75909-CCNK_HUMAN
    Recommended name:
    Cyclin-K
    Protein Accession:
    O75909
    Secondary Accessions:
    • Q59FT6
    • Q86U16
    • Q96B63
    • Q9NNY9

    Protein attributes for CCNK Gene

    Size:
    580 amino acids
    Molecular mass:
    64240 Da
    Quaternary structure:
    • Regulatory subunit of cyclin-dependent kinases. Identified in a complex with a kinase and the RNA polymerase II holoenzyme. Interacts with POLR2A. Interacts with CDK12 and CDK13. Interacts with CDK9 according to PubMed:10574912; does not interact with CDK9 according to PubMed:22012619.

    Three dimensional structures from OCA and Proteopedia for CCNK Gene

    Alternative splice isoforms for CCNK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNK Gene

Post-translational modifications for CCNK Gene

  • Ubiquitination at posLast=166166
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNK Gene

No data available for DME Specific Peptides for CCNK Gene

Domains & Families for CCNK Gene

Gene Families for CCNK Gene

Protein Domains for CCNK Gene

Suggested Antigen Peptide Sequences for CCNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75909

UniProtKB/Swiss-Prot:

CCNK_HUMAN :
  • Belongs to the cyclin family. Cyclin C subfamily.
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.
genes like me logo Genes that share domains with CCNK: view

Function for CCNK Gene

Molecular function for CCNK Gene

GENATLAS Biochemistry:
cyclin K,RNA polymerase II associated cyclin,ubiquitously expressed but most abundant in developing germ cells of adult testis and ovary,likely involved in the regulation of basal transcription
UniProtKB/Swiss-Prot Function:
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

Gene Ontology (GO) - Molecular Function for CCNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IDA 9632813
GO:0005515 protein binding IPI 16189514
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA 9632813
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IBA --
genes like me logo Genes that share ontologies with CCNK: view
genes like me logo Genes that share phenotypes with CCNK: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCNK
  • Applied Biological Materials Clones for CCNK

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNK Gene

Localization for CCNK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNK gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002944 cyclin K-CDK12 complex IPI 22012619
GO:0002945 cyclin K-CDK13 complex IPI 22012619
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS,IDA --
genes like me logo Genes that share ontologies with CCNK: view

Pathways & Interactions for CCNK Gene

genes like me logo Genes that share pathways with CCNK: view

Pathways by source for CCNK Gene

Gene Ontology (GO) - Biological Process for CCNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9632813
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with CCNK: view

No data available for SIGNOR curated interactions for CCNK Gene

Drugs & Compounds for CCNK Gene

No Compound Related Data Available

Transcripts for CCNK Gene

Unigene Clusters for CCNK Gene

Cyclin K:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCNK
  • Applied Biological Materials Clones for CCNK

Alternative Splicing Database (ASD) splice patterns (SP) for CCNK Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6: - -

Relevant External Links for CCNK Gene

GeneLoc Exon Structure for
CCNK
ECgene alternative splicing isoforms for
CCNK

Expression for CCNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNK Gene

This gene is overexpressed in Lymph node (16.2), Lung (10.6), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCNK Gene



Protein tissue co-expression partners for CCNK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNK Gene:

CCNK

SOURCE GeneReport for Unigene cluster for CCNK Gene:

Hs.510409

mRNA Expression by UniProt/SwissProt for CCNK Gene:

O75909-CCNK_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels in testis.

Evidence on tissue expression from TISSUES for CCNK Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Blood(4.1)
  • Intestine(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with CCNK: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNK Gene

Orthologs for CCNK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNK 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia CCNK 34 35
  • 90.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNK 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnk 34 16 35
  • 88.45 (n)
rat
(Rattus norvegicus)
Mammalia Ccnk 34
  • 87.76 (n)
dog
(Canis familiaris)
Mammalia CCNK 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNK 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNK 34 35
  • 78.87 (n)
lizard
(Anolis carolinensis)
Reptilia CCNK 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnk 34
  • 73.77 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4340 34
zebrafish
(Danio rerio)
Actinopterygii ccnk 34 35
  • 68.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CycK 36 35
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea ccnk-1 35
  • 40 (a)
OneToOne
F43D2.1 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8802 35
  • 70 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pch1 34
  • 46.52 (n)
Species where no ortholog for CCNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNK Gene

ENSEMBL:
Gene Tree for CCNK (if available)
TreeFam:
Gene Tree for CCNK (if available)

Paralogs for CCNK Gene

Paralogs for CCNK Gene

(3) SIMAP similar genes for CCNK Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCNK: view

Variants for CCNK Gene

Sequence variations from dbSNP and Humsavar for CCNK Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000002771 -- 99,508,730(+) TTGCT(C/G)TTCCA intron-variant
rs1000051674 -- 99,508,549(+) GGCGC(A/G)GTAAA intron-variant
rs1000090247 -- 99,498,027(+) CATGC(C/T)GTGGT intron-variant
rs1000318344 -- 99,504,745(+) GTGCC(C/T)AGCCT intron-variant
rs1000363308 -- 99,496,187(+) GTGTT(C/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNK Gene

Variant ID Type Subtype PubMed ID
esv3635481 CNV gain 21293372
esv997017 OTHER inversion 20482838
nsv952236 CNV deletion 24416366

Variation tolerance for CCNK Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNK Gene

Disorders for CCNK Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCNK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kaposi sarcoma
  • human herpesvirus 8
- elite association - COSMIC cancer census association via MalaCards
Search CCNK in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNK

Genetic Association Database (GAD)
CCNK
Human Genome Epidemiology (HuGE) Navigator
CCNK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNK
genes like me logo Genes that share disorders with CCNK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNK Gene

Publications for CCNK Gene

  1. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. (PMID: 9632813) Edwards M.C. … Elledge S.J. (Mol. Cell. Biol. 1998) 2 3 4 22 64
  2. Crystal structure of human cyclin K, a positive regulator of cyclin- dependent kinase 9. (PMID: 17169370) Baek K. … Ladias J.A. (J. Mol. Biol. 2007) 3 4 22 64
  3. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. (PMID: 10574912) Fu T.J. … Flores O. (J. Biol. Chem. 1999) 2 3 4 64
  4. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. (PMID: 22012619) Blazek D. … Peterlin B.M. (Genes Dev. 2011) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for CCNK Gene

  • Addgene plasmids for CCNK

Sources for CCNK Gene

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