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CCNK Gene

protein-coding   GIFtS: 61
GCID: GC14P099947

Cyclin K

  See CCNK-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin K1 2
CPR42 3
cyclin-K2

External Ids:    HGNC: 15961   Entrez Gene: 88122   Ensembl: ENSG000000900617   OMIM: 6035445   UniProtKB: O759093   

Export aliases for CCNK gene to outside databases

Previous GC identifers: GC14P097459 GC14P093763 GC14P097937 GC14P097949 GC14P099017 GC14P080131


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNK Gene:
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate
transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate
the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in
regulating CDK and RNA polymerase II activities. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNK Gene:
CCNK (cyclin K) is a protein-coding gene. Diseases associated with CCNK include pthirus pubis infestation, and kaposi's sarcoma. GO annotations related to this gene include RNA polymerase II carboxy-terminal domain kinase activity and protein kinase binding. An important paralog of this gene is CCNL2.

UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
Function: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward
both RNA polymerase II C-terminal domain and CDK2 (CAK)

Gene Wiki entry for CCNK (Cyclin K) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNK gene promoter:
         MAZR   p53   FOXD1   CUTL1   POU6F1 (c2)   FOXO4   STAT3   NF-Y   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNK promoter sequence
   Search Chromatin IP Primers for CCNK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32

CCNK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNK gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P099947:  view genomic region     (about GC identifiers)

Start:
99,947,506 bp from pter      End:
100,001,381 bp from pter
Size:
53,876 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909 (See protein sequence)
Recommended Name: Cyclin-K  
Size: 580 amino acids; 64240 Da
Subunit: Part of a cyclin-kinase pair in the RNA polymerase II holoenzyme. Binds to CDK9
2 PDB 3D structures from and Proteopedia for CCNK:
2I53 (3D)        4CJY (3D)    
Secondary accessions: Q59FT6 Q86U16 Q96B63 Q9NNY9
Alternative splicing: 4 isoforms:  O75909-3   O75909-2   O75909-1   O75909-4   

Explore the universe of human proteins at neXtProt for CCNK: NX_O75909

Explore proteomics data for CCNK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys166
  • Modification sites at PhosphoSitePlus

  • See CCNK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001092872.1  
    ENSEMBL proteins: 
     ENSP00000374529   ENSP00000450792   ENSP00000452307   ENSP00000450440  

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    Cloud-Clone Corp. Proteins for CCNK

     
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    antibodies-online proteins for CCNK (4 products) 

     
    antibodies-online peptides for CCNK

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    antibodies-online antibodies for CCNK (25 products) 

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    antibodies-online kits for CCNK (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR015429 Cyclin_C/H/T/L

    Graphical View of Domain Structure for InterPro Entry O75909

    ProtoNet protein and cluster: O75909

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    Find genes that share domains with CCNK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNK_HUMAN, O75909
    Function: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward
    both RNA polymerase II C-terminal domain and CDK2 (CAK)

         Genatlas biochemistry entry for CCNK:
    cyclin K,RNA polymerase II associated cyclin,ubiquitously expressed but most abundant in developing germ cells of
    adult testis and ovary,likely involved in the regulation of basal transcription

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IDA9632813
    GO:0005515protein binding IPI16713569
    GO:0008353RNA polymerase II carboxy-terminal domain kinase activity IDA9632813
    GO:0019901protein kinase binding IPI--
         
    Find genes that share ontologies with CCNK           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CCNK:
     Decreased Hepatitis C virus re  Decreased POU5F1-GFP protein e  Decreased homologous recombina 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ccnk):
     mortality/aging 

    Find genes that share phenotypes with CCNK           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCNK

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCNK:
    hsa-mir-296-3p (MIRT038452), hsa-let-7b-5p (MIRT032200), hsa-mir-484 (MIRT041776)

    Block miRNA regulation of human, mouse, rat CCNK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNK (see all 33):
    hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-30d hsa-miR-624 hsa-miR-30a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCCNK 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCNK
    Predesigned siRNA for gene silencing in human, mouse, rat CCNK

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CCNK (NM_001099402)
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    Addgene plasmids for CCNK 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002944cyclin K-CDK12 complex IPI--
    GO:0002945cyclin K-CDK13 complex IPI--

    Find genes that share ontologies with CCNK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNK About    
    See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for CCNK
        Direct p53 effectors


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCNK
    Interactions:

        GeneGlobe Interaction Network for CCNK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNK (O759091, 2, 3 ENSP000003745294) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-739806,EBI-930964 MINT-2865482 MINT-2855089 I2D: score=3 STRING: ENSP00000244769
    CCDC85BQ158342, 3, ENSP000003116954MINT-66150 I2D: score=5 STRING: ENSP00000311695
    HMG20AQ9NP662, 3, ENSP000003368564MINT-68052 I2D: score=5 STRING: ENSP00000336856
    RBPMSQ930622, 3, ENSP000003401764MINT-66934 I2D: score=5 STRING: ENSP00000340176
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-67823 I2D: score=5 STRING: ENSP00000360441
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS9632813
    GO:0006468protein phosphorylation IDA9632813

    Find genes that share ontologies with CCNK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNK



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNK gene (2 alternative transcripts): 
    NM_001099402.1  NM_003858.3  

    Unigene Cluster for CCNK:

    Cyclin K
    Hs.510409  [show with all ESTs]
    Unigene Representative Sequence: AB209373
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557165 ENST00000389879(uc001ygi.4) ENST00000553636 ENST00000557441
    ENST00000555049 ENST00000555842 ENST00000556641 ENST00000555942 ENST00000553865

    miRNA
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    Block miRNA regulation of human, mouse, rat CCNK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNK (see all 33):
    hsa-miR-300 hsa-miR-513a-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-30d hsa-miR-624 hsa-miR-30a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidCCNK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNK
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    GenScript: all cDNA clones in your preferred vector: CCNK (NM_001099402)
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    Addgene plasmids for CCNK 
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    OriGene qPCR primer pairs and template standards for CCNK
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNK
      QuantiTect SYBR Green Assays in human, mouse, rat CCNK
      QuantiFast Probe-based Assays in human, mouse, rat CCNK

    Additional mRNA sequence: 

    AB209373.1 AK000799.1 AK124466.1 AK311075.1 BC015935.1 BT006950.1 BX247958.1 

    13 DOTS entries:

    DT.215479  DT.95098492  DT.100723022  DT.100812855  DT.40192993  DT.86999816  DT.91946474  DT.102830769 
    DT.91990905  DT.120780549  DT.92445866  DT.95093600  DT.95150722 

    Selected AceView cDNA sequences (see all 175):

    BM726838 BC015935 AI422138 AI935458 AA512928 BM504212 BM508958 CN484736 
    CD722655 AI335876 AW189101 AI082525 AA609588 NM_003858 CA398104 AA298483 
    BF725949 AI916400 W74357 CF541374 BX247958 AW450108 BX089377 CA398105 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCNK (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                -                                                               
    SP2:              -     -           -                                                               
    SP3:                    -           -                                                               
    SP4:              -                 -                                                               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CCNK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACCCAGAA
    CCNK Expression
    About this image


    CCNK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CCNK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.510409

    UniProtKB/Swiss-Prot: CCNK_HUMAN, O75909
    Tissue specificity: Ubiquitously expressed. Highest levels in testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCNK gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnk1 , 5 cyclin K1, 5 88.45(n)1
    95(a)1
      12 (59.23 cM)5
    124541  NM_009832.21  NP_033962.21 
     1081797385 
    chicken
    (Gallus gallus)
    Aves CCNK1 cyclin K 78.87(n)
    89.54(a)
      423446  NM_001031209.1  NP_001026380.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNK6
    cyclin K
    81(a)
    1 ↔ 1
    GL343270.1(1816456-1832354)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.43402 Xenopus laevis transcribed sequence with strong similarity more 80.72(n)    CA791066.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnk1 cyclin K 68.98(n)
    75.34(a)
      569432  NM_001163779.1  NP_001157251.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycK3 cyclin-dependent protein kinase,
    regulator
    63(a)   40E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea F43D2.13 G1/S-specfic cyclin C like 39(a)   V(14615155-14616187)   --


    ENSEMBL Gene Tree for CCNK (if available)
    TreeFam Gene Tree for CCNK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNK gene
    CCNL22  CCNT22  CCNC2  CCNL12  FAM58A2  CCNT12  
    3 SIMAP similar genes for CCNK using alignment to 4 protein entries:     CCNK_HUMAN (see all proteins):
    CYCT1b    CCNT2    FAM58A

    Find genes that share paralogs with CCNK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNK (see all 559)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890570531,2
    --99949245(+) TTCTTA/TAAAAT 1 -- int10--------
    rs1419984421,2
    --99949254(+) ATTGGA/GTAAGG 1 -- int10--------
    rs1462436311,2
    C--99949358(+) TTGCAA/GATGAC 1 -- int10--------
    rs80151371,2
    H--99949402(+) TCCTAA/GAAGTA 1 -- int14Minor allele frequency- G:0.00NS EA 408
    rs1932678421,2
    --99949451(+) TTTTCA/GCATAG 1 -- int10--------
    rs1391302191,2
    C--99949452(+) TTTCAC/GATAGA 1 -- int10--------
    rs80153041,2
    C,F,A--99949522(+) GGAAGA/GGCCAA 1 -- int18Minor allele frequency- G:0.46NA WA EA 368
    rs1848423821,2
    --99949751(+) CAGATA/GTGGAG 1 -- int10--------
    rs786204581,2
    C,F--99949883(+) CCCTGT/ACTCAA 1 -- int12Minor allele frequency- A:0.15CSA WA 120
    rs1891874791,2
    --99949950(+) GGTGAC/TTGGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCNK (99947506 - 100001381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCNK:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1977n71CNV Loss21882294
    esv997017OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603544    OMIM disorders: --

    2 diseases for CCNK:    
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    pthirus pubis infestation    kaposi's sarcoma

    1 disease from the University of Copenhagen DISEASES database for CCNK:
    Pthirus pubis infestation

    Find genes that share disorders with CCNK           About GenesLikeMe

    4 Novoseek inferred disease relationships for CCNK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kaposi sarcoma 46.3 2 15870436 (1), 15144954 (1)
    lymphoma 17.1 2 20331971 (1), 16115893 (1)
    tumors 0 2 12743275 (1), 11988847 (1)
    cancer 0 1 16552186 (1)

    Genetic Association Database (GAD): CCNK
    Human Genome Epidemiology (HuGE) Navigator: CCNK (1 document)

    Export disorders for CCNK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNK gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with CCNK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. (PubMed id 9632813)1, 2, 3, 9 Edwards M.C.... Elledge S.J. (Mol. Cell. Biol. 1998)
    2. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. (PubMed id 10574912)1, 2, 3 Fu T.J.... Flores O. (J. Biol. Chem. 1999)
    3. Crystal structure of human cyclin K, a positive regulator of cyclin- dependent kinase 9. (PubMed id 17169370)1, 2, 9 Baek K.... Ladias J.A. (J. Mol. Biol. 2007)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Cyclin K as a direct transcriptional target of the p53 tumor suppressor. (PubMed id 11988847)1, 9 Mori T....Arakawa H. (Neoplasia 2002)
    7. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. (PubMed id 11884399)1, 9 Lin X.... Peterlin B.M. (J. Biol. Chem. 2002)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8812 HGNC: 1596 AceView: CCNK Ensembl:ENSG00000090061 euGenes: HUgn8812
    ECgene: CCNK H-InvDB: CCNK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNK Genetics and Cytogenetics in Oncology and Haematology
    NIEHS SNPshttp://egp.gs.washington.edu/data/ccnk/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNK gene:
    Search GeneIP for patents involving CCNK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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