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CCNJL Gene

protein-coding   GIFtS: 45
GCID: GC05M159678

Cyclin J-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cyclin J-Like1 2
Cyclin-J-Like Protein2

External Ids:    HGNC: 258761   Entrez Gene: 796162   Ensembl: ENSG000001350837   UniProtKB: Q8IV133   
ORGUL members:         

Export aliases for CCNJL gene to outside databases

Previous GC identifers: GC05M159612 GC05M154772


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCNJL Gene:
CCNJL (cyclin J-like) is a protein-coding gene. An important paralog of this gene is CCNJ.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNJL gene promoter:
         AhR   NF-1/L   NF-1   Elk-1   RelA   CUTL1   c-Ets-1   AREB6   HSF2   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNJL promoter sequence
   Search Chromatin IP Primers for CCNJL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNJL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

CCNJL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNJL gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M159678:  view genomic region     (about GC identifiers)

Start:
159,678,659 bp from pter      End:
159,772,403 bp from pter
Size:
93,745 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCNJL_HUMAN, Q8IV13 (See protein sequence)
Recommended Name: Cyclin-J-like protein  
Size: 435 amino acids; 48406 Da
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=AAH13353.1; Type=Erroneous initiation; Sequence=BAB14856.1; Type=Erroneous initiation;
Secondary accessions: Q6ZN43 Q9H7W8
Alternative splicing: 2 isoforms:  Q8IV13-1   Q8IV13-2   

Explore the universe of human proteins at neXtProt for CCNJL: NX_Q8IV13

Explore proteomics data for CCNJL at MOPED


See CCNJL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_078841.3  
ENSEMBL proteins: 
 ENSP00000377547   ENSP00000257536   ENSP00000427960   ENSP00000428836   ENSP00000446367  
 ENSP00000444778  

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antibodies-online proteins for CCNJL (3 products) 

 
antibodies-online peptides for CCNJL

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antibodies-online kits for CCNJL (16 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR013763 Cyclin-like
 IPR006671 Cyclin_N
 IPR004367 Cyclin_C-dom

Graphical View of Domain Structure for InterPro Entry Q8IV13

ProtoNet protein and cluster: Q8IV13

1 Blocks protein domain: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNJL_HUMAN, Q8IV13
Similarity: Belongs to the cyclin family. Cyclin J subfamily
Similarity: Contains 1 cyclin N-terminal domain


Find genes that share domains with CCNJL           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CCNJL

miRNA
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Block miRNA regulation of human, mouse, rat CCNJL using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CCNJL (see all 60):
hsa-miR-193a-3p hsa-miR-3146 hsa-miR-429 hsa-let-7d hsa-miR-15a hsa-miR-25 hsa-miR-605 hsa-miR-30d
SwitchGear 3'UTR luciferase reporter plasmidCCNJL 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNJL

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNJL


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus2
cytosol1
extracellular1
mitochondrion1
peroxisome1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with CCNJL           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCNJL
Interactions:

    Search GeneGlobe Interaction Network for CCNJL

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

Selected Interacting proteins for CCNJL (Q8IV133 ENSP000003775474) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
KRTAP4-12Q9BQ663I2D: score=1 
PLSCR1O151623I2D: score=1 
RHOXF2Q9BQY43I2D: score=1 
CLK1ENSP000003268304STRING: ENSP00000326830
CDK2ENSP000002669704STRING: ENSP00000266970
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CCNJL



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CCNJL gene: 
NM_024565.5  

Unigene Cluster for CCNJL:

Cyclin J-like
Hs.14070  [show with all ESTs]
Unigene Representative Sequence: NM_024565
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000393977(uc003lyb.1 uc011dee.1) ENST00000377503(uc003lyc.1)
ENST00000257536(uc011def.1) ENST00000519673 ENST00000520748 ENST00000518764
ENST00000521643 ENST00000541762 ENST00000505287
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate CCNJL (see all 60):
hsa-miR-193a-3p hsa-miR-3146 hsa-miR-429 hsa-let-7d hsa-miR-15a hsa-miR-25 hsa-miR-605 hsa-miR-30d
SwitchGear 3'UTR luciferase reporter plasmidCCNJL 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat CCNJL
Clone
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GenScript: all cDNA clones in your preferred vector: CCNJL (NM_024565)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNJL
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for CCNJL
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNJL
  QuantiTect SYBR Green Assays in human, mouse, rat CCNJL
  QuantiFast Probe-based Assays in human, mouse, rat CCNJL

Additional mRNA sequence: 

AK024228.1 AK294000.1 AK302823.1 BC013353.2 BC035871.1 

4 DOTS entries:

DT.440792  DT.95138072  DT.92017482  DT.40189495 

Selected AceView cDNA sequences (see all 55):

NM_024565 BM701110 AA355535 AA894965 BM981490 C01507 AI139936 BC013353 
BC035871 BM715897 AK131381 AW025049 AW207204 BE793555 AI049552 BM051160 
T89503 AA515524 AU126411 BE674592 AK024228 BF111450 AA677771 BM903757 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CCNJL    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1:              -                                             
SP2:                    -                       -               
SP3:              -     -                                       


ECgene alternative splicing isoforms for CCNJL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCNJL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGACAGTAA
CCNJL Expression
About this image


CCNJL expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Blood (Hematopoietic System)
         Granulocytes Peripheral Blood
CCNJL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCNJL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.14070
    Custom PCR Arrays for CCNJL
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNJL

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CCNJL gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves CCNJL6
cyclin J-like
49(a)
1 ↔ 1
13(7192751-7211125)
lizard
(Anolis carolinensis)
Reptilia CCNJL6
cyclin J-like
47(a)
1 ↔ 1
GL343286.1(1162197-1174908)
zebrafish
(Danio rerio)
Actinopterygii CCNJL6
cyclin J-like
45(a)
1 ↔ 1
21(28798829-28826582) ENSDARG00000077116
fruit fly
(Drosophila melanogaster)
Insecta CycJ6
Cyclin J
19(a)
1 → many
3L(3466414-3468098)
        Species with no ortholog for CCNJL

ENSEMBL Gene Tree for CCNJL (if available)
TreeFam Gene Tree for CCNJL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CCNJL gene
CCNJ2  
10 SIMAP similar genes for CCNJL using alignment to 5 protein entries:     CCNJL_HUMAN (see all proteins):
C12orf76    SH2B3    SNRPF    MST132    COQ5    KIAA1651
CCNJ    PFKFB3    TUBA1C    ATF1

Find genes that share paralogs with CCNJL           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CCNJL (see all 1490)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1863361351,2
--159678185(+) CGTAAA/GAGCAA 1 -- ds50010--------
rs1909387271,2
--159678248(+) ATCATA/GCCTGA 1 -- ds50010--------
rs1156769041,2
C,F--159678249(+) TCATGC/TCTGAG 1 -- ds50011Minor allele frequency- T:0.03WA 118
rs1446500101,2
--159678432(+) TGGAAA/TAACCC 1 -- ds50010--------
rs1484757271,2
--159678483(+) CCTCCA/GCTGGC 1 -- ds50010--------
rs1831525711,2
--159678595(+) TGCTCA/GCCAGG 1 -- ds50010--------
rs738173581,2
C,F--159678628(+) GGGGCC/TGGCCC 1 -- ds50012Minor allele frequency- T:0.03WA 120
rs1426341321,2
--159678659(+) AGAGGC/TGAGAG 1 -- ds50010--------
rs37497981,2
C,F,H--159678995(+) CCTGGC/TGGCCC 1 -- ut31 ese320Minor allele frequency- T:0.10EA NS NA CSA WA 3789
rs1886188741,2
--159678997(+) TGGCGA/GCCCCT 1 -- ut310--------

HapMap Linkage Disequilibrium report for CCNJL (159678659 - 159772403 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CCNJL:    About this table    
Variant IDTypeSubtypePubMed ID
nsv5096CNV Insertion18451855
dgv359n21CNV Loss19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CCNJL
DNA2.0 Custom Variant and Variant Library Synthesis for CCNJL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with CCNJL           About GenesLikeMe

Genetic Association Database (GAD): CCNJL

Export disorders for CCNJL gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CCNJL gene integrated from 10 sources:
(articles sorted by number of sources associating them with CCNJL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79616 HGNC: 25876 AceView: FLJ14166 Ensembl:ENSG00000135083 euGenes: HUgn79616
ECgene: CCNJL H-InvDB: CCNJL

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CCNJL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CCNJL gene:
Search GeneIP for patents involving CCNJL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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