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Aliases for CCNJL Gene

Aliases for CCNJL Gene

  • Cyclin J Like 2 3 5
  • Cyclin J-Like 2

External Ids for CCNJL Gene

Previous GeneCards Identifiers for CCNJL Gene

  • GC05M159612
  • GC05M159678
  • GC05M154772

Summaries for CCNJL Gene

GeneCards Summary for CCNJL Gene

CCNJL (Cyclin J Like) is a Protein Coding gene. An important paralog of this gene is CCNJ.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNJL Gene

Genomics for CCNJL Gene

Regulatory Elements for CCNJL Gene

Enhancers for CCNJL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G160293 1.2 FANTOM5 Ensembl ENCODE 40.6 +51.1 51089 1.6 RFX1 MTA2 ZBTB11 NR2F1 IKZF1 MAX BMI1 EBF1 CCNJL SLU7 PWWP2A GC05P160291 SNRPEP1
GH05G160209 1.2 FANTOM5 ENCODE 11.8 +134.9 134877 2.9 HDAC1 PKNOX1 ARNT NFRKB ZBTB40 ELK1 FOS ELF1 ZEB2 POLR2H FABP6 CCNJL C1QTNF2 LOC105377690
GH05G160230 1.2 FANTOM5 Ensembl ENCODE 11.7 +114.2 114232 0.9 CTCF MTA2 EBF1 RELA IKZF1 SMC3 RELB ZBTB33 FOS IKZF2 CCNJL SLU7 ENSG00000253772 LOC105377690
GH05G160187 1.2 Ensembl ENCODE 11.5 +157.2 157153 2.3 HDGF TBP CBX3 RB1 NFXL1 RAD21 TCF12 GTF3C2 GATA2 ZNF143 CCNJL ZBED8 FABP6 PWWP2A LOC105377690
GH05G160080 1.2 Ensembl ENCODE 11.3 +264.4 264402 1.4 PKNOX1 WRNIP1 FEZF1 TCF12 TSHZ1 REST ZNF592 SMARCA4 PBX2 HMBOX1 PWWP2A FABP6 CCNJL ZBED8 GC05P160046
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNJL on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNJL Gene

Chromosome:
5
Start:
160,251,652 bp from pter
End:
160,345,396 bp from pter
Size:
93,745 bases
Orientation:
Minus strand

Genomic View for CCNJL Gene

Genes around CCNJL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNJL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNJL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNJL Gene

Proteins for CCNJL Gene

  • Protein details for CCNJL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV13-CCNJL_HUMAN
    Recommended name:
    Cyclin-J-like protein
    Protein Accession:
    Q8IV13
    Secondary Accessions:
    • Q6ZN43
    • Q9H7W8

    Protein attributes for CCNJL Gene

    Size:
    435 amino acids
    Molecular mass:
    48406 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13353.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14856.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNJL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNJL Gene

Post-translational modifications for CCNJL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNJL Gene

Domains & Families for CCNJL Gene

Gene Families for CCNJL Gene

Protein Domains for CCNJL Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IV13

UniProtKB/Swiss-Prot:

CCNJL_HUMAN :
  • Belongs to the cyclin family. Cyclin J subfamily.
Family:
  • Belongs to the cyclin family. Cyclin J subfamily.
genes like me logo Genes that share domains with CCNJL: view

Function for CCNJL Gene

genes like me logo Genes that share phenotypes with CCNJL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCNJL Gene

Localization for CCNJL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNJL gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCNJL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CCNJL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNJL Gene

Pathways & Interactions for CCNJL Gene

SuperPathways for CCNJL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNJL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCNJL Gene

Drugs & Compounds for CCNJL Gene

No Compound Related Data Available

Transcripts for CCNJL Gene

Unigene Clusters for CCNJL Gene

Cyclin J-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNJL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for CCNJL Gene

GeneLoc Exon Structure for
CCNJL
ECgene alternative splicing isoforms for
CCNJL

Expression for CCNJL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNJL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNJL Gene

This gene is overexpressed in Whole Blood (x19.7), Brain - Cerebellar Hemisphere (x5.3), and Brain - Cerebellum (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of CCNJL Gene:

CCNJL

SOURCE GeneReport for Unigene cluster for CCNJL Gene:

Hs.14070

Evidence on tissue expression from TISSUES for CCNJL Gene

  • Nervous system(4.2)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with CCNJL: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNJL Gene

Orthologs for CCNJL Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNJL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNJL 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnjl 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNJL 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CCNJL 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNJL 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNJL 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNJL 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCNJL 35
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycJ 35
  • 19 (a)
OneToMany
Species where no ortholog for CCNJL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNJL Gene

ENSEMBL:
Gene Tree for CCNJL (if available)
TreeFam:
Gene Tree for CCNJL (if available)

Paralogs for CCNJL Gene

Paralogs for CCNJL Gene

(10) SIMAP similar genes for CCNJL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CCNJL: view

Variants for CCNJL Gene

Sequence variations from dbSNP and Humsavar for CCNJL Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000032667 -- 160,259,311(+) CCCTT(C/T)CTTTG intron-variant
rs1000072348 -- 160,341,145(+) CCAGG(C/T)TTACT upstream-variant-2KB
rs1000088370 -- 160,270,421(+) CCTGG(C/G)TGACA intron-variant, upstream-variant-2KB
rs1000090505 -- 160,265,358(+) GCCGG(A/C)CAGGT intron-variant
rs1000091299 -- 160,314,730(+) AAAAC(A/T)TTAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCNJL Gene

Variant ID Type Subtype PubMed ID
dgv359n21 CNV loss 19592680
esv3607364 CNV gain 21293372
esv3607367 CNV gain 21293372
esv3607369 CNV loss 21293372
esv3607370 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv5096 CNV insertion 18451855

Variation tolerance for CCNJL Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNJL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNJL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNJL Gene

Disorders for CCNJL Gene

Relevant External Links for CCNJL

Genetic Association Database (GAD)
CCNJL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNJL

No disorders were found for CCNJL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNJL Gene

Publications for CCNJL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for CCNJL Gene

Sources for CCNJL Gene

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