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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNJL Gene

protein-coding   GIFtS: 44
GCID: GC05M159678

Cyclin J-Like

  Search for CCNJL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin J-Like1 2
Cyclin-J-Like Protein2

External Ids:    HGNC: 258761   Entrez Gene: 796162   Ensembl: ENSG000001350837   UniProtKB: Q8IV133   

Export aliases for CCNJL gene to outside databases

Previous GC identifers: GC05M159612 GC05M154772


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCNJL Gene: 
CCNJL (cyclin J-like) is a protein-coding gene. An important paralog of this gene is CCNJ.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNJL gene promoter:
         AhR   NF-1/L   NF-1   Elk-1   RelA   CUTL1   c-Ets-1   AREB6   HSF2   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNJL promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNJL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNJL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

CCNJL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNJL gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M159678:  view genomic region     (about GC identifiers)

Start:
159,678,659 bp from pter      End:
159,772,403 bp from pter
Size:
93,745 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNJL_HUMAN, Q8IV13 (See protein sequence)
Recommended Name: Cyclin-J-like protein  
Size: 435 amino acids; 48406 Da
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Sequence caution: Sequence=AAH13353.1; Type=Erroneous initiation; Sequence=BAB14856.1; Type=Erroneous initiation;
Secondary accessions: Q6ZN43 Q9H7W8
Alternative splicing: 2 isoforms:  Q8IV13-1   Q8IV13-2   

Explore the universe of human proteins at neXtProt for CCNJL: NX_Q8IV13

Explore proteomics data for CCNJL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IV13

  • CCNJL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNJL Protein Expression
    REFSEQ proteins: NP_078841.3  
    ENSEMBL proteins: 
     ENSP00000377547   ENSP00000257536   ENSP00000427960   ENSP00000428836   ENSP00000446367  
     ENSP00000444778  

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    Novus Biologicals CCNJL Protein
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for CCNJL 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CCNJL for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CCNJL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom

    Graphical View of Domain Structure for InterPro Entry Q8IV13

    ProtoNet protein and cluster: Q8IV13

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNJL_HUMAN, Q8IV13
    Similarity: Belongs to the cyclin family. Cyclin J subfamily
    Similarity: Contains 1 cyclin N-terminal domain


    CCNJL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNJL 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNJL 
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    SwitchGear 3'UTR luciferase reporter plasmidCCNJL 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CCNJL (NM_024565)
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                         Customized lentivirus expression plasmids for stable overexpression of CCNJL 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNJL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCNJL

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for CCNJL (Q8IV133 ENSP000003775474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ663I2D: score=1 
    PLSCR1O151623I2D: score=1 
    RHOXF2Q9BQY43I2D: score=1 
    CLK1ENSP000003268304STRING: ENSP00000326830
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNJL

    Search CenterWatch for drugs/clinical trials and news about CCNJL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNJL gene: 
    NM_024565.5  

    Unigene Cluster for CCNJL:

    Cyclin J-like
    Hs.14070  [show with all ESTs]
    Unigene Representative Sequence: NM_024565
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393977(uc003lyb.1 uc011dee.1) ENST00000377503(uc003lyc.1)
    ENST00000257536(uc011def.1) ENST00000519673 ENST00000520748 ENST00000518764
    ENST00000521643 ENST00000541762 ENST00000505287
    miRNA
    Products:
         
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNJL (see all 60):
    hsa-miR-193a-3p hsa-miR-3146 hsa-miR-429 hsa-let-7d hsa-miR-15a hsa-miR-25 hsa-miR-605 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidCCNJL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCNJL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNJL
    Clone
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    OriGene clones in human, mouse for CCNJL (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCNJL (NM_024565)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNJL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNJL
    Sirion Biotech Customized lentivirus for stable overexpression of CCNJL 
                         Customized lentivirus expression plasmids for stable overexpression of CCNJL 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCNJL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCNJL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNJL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNJL

    Additional mRNA sequence: 

    AK024228.1 AK294000.1 AK302823.1 BC013353.2 BC035871.1 

    4 DOTS entries:

    DT.440792  DT.95138072  DT.92017482  DT.40189495 

    24/55 AceView cDNA sequences (see all 55):

    AK131381 BC035871 BM981490 BM701110 BC013353 AW025049 AA894965 NM_024565 
    BM715897 AA355535 AI139936 C01507 AW207204 BG764802 BF111450 AA515524 
    AI049552 BE793555 AK024228 BM051160 AA005222 BE218730 BE797409 AA677771 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCNJL    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:              -                                             
    SP2:                    -                       -               
    SP3:              -     -                                       


    ECgene alternative splicing isoforms for CCNJL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNJL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACAGTAA
    CCNJL Expression
    About this image


    See CCNJL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNJL

    SOURCE GeneReport for Unigene cluster: Hs.14070
        SABiosciences Custom PCR Arrays for CCNJL
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNJL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNJL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCNJL gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CCNJL6
    cyclin J-like
    41(a)
    1 ↔ 1
    13(7192751-7211125)
    lizard
    (Anolis carolinensis)
    Reptilia CCNJL6
    cyclin J-like
    42(a)
    1 ↔ 1
    GL343286.1(1162197-1174908)
    zebrafish
    (Danio rerio)
    Actinopterygii CCNJL6
    cyclin J-like
    43(a)
    1 ↔ 1
    21(28798829-28825696)
    fruit fly
    (Drosophila melanogaster)
    Insecta CycJ6
    Cyclin J
    18(a)
    1 → many
    3L(3466414-3468098)
            Species with no ortholog for CCNJL

    ENSEMBL Gene Tree for CCNJL (if available)
    TreeFam Gene Tree for CCNJL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNJL gene
    CCNJ2  
    10 SIMAP similar genes for CCNJL using alignment to 5 protein entries:     CCNJL_HUMAN (see all proteins):
    C12orf76    SH2B3    SNRPF    MST132    COQ5    KIAA1651
    CCNJ    PFKFB3    TUBA1C    ATF1

    CCNJL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1490 SNPs in CCNJL are shown (see all 1490)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863361351,2
    --159678185(+) CGTAAA/GAGCAA 1 -- ds50010--------
    rs1909387271,2
    --159678248(+) ATCATA/GCCTGA 1 -- ds50010--------
    rs1156769041,2
    C,F--159678249(+) TCATGC/TCTGAG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1446500101,2
    --159678432(+) TGGAAA/TAACCC 1 -- ds50010--------
    rs1484757271,2
    --159678483(+) CCTCCA/GCTGGC 1 -- ds50010--------
    rs1831525711,2
    --159678595(+) TGCTCA/GCCAGG 1 -- ds50010--------
    rs738173581,2
    C,F--159678628(+) GGGGCC/TGGCCC 1 -- ds50012Minor allele frequency- T:0.03WA 120
    rs1426341321,2
    --159678659(+) AGAGGC/TGAGAG 1 -- ds50010--------
    rs37497981,2
    C,F,H--159678995(+) CCTGGC/TGGCCC 1 -- ut31 ese320Minor allele frequency- T:0.10EA NS NA CSA WA 3789
    rs1886188741,2
    --159678997(+) TGGCGA/GCCCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCNJL (159678659 - 159772403 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCNJL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5096CNV Insertion18451855
    dgv359n21CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNJL
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNJL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCNJL for disorders           About MalaCards

    CCNJL for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCNJL

    Export disorders for CCNJL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNJL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCNJL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79616 HGNC: 25876 AceView: FLJ14166 Ensembl:ENSG00000135083 euGenes: HUgn79616
    ECgene: CCNJL H-InvDB: CCNJL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNJL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNJL gene:
    Search GeneIP for patents involving CCNJL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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