Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCNJ Gene

Aliases for CCNJ Gene

  • Cyclin J 2 3 5
  • BA690P14.1 3
  • Cyclin-J 3

External Ids for CCNJ Gene

Previous GeneCards Identifiers for CCNJ Gene

  • GC10P097468
  • GC10P097793
  • GC10P091430

Summaries for CCNJ Gene

GeneCards Summary for CCNJ Gene

CCNJ (Cyclin J) is a Protein Coding gene. An important paralog of this gene is CCNJL.

Additional gene information for CCNJ Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNJ Gene

Genomics for CCNJ Gene

Regulatory Elements for CCNJ Gene

Enhancers for CCNJ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H096579 1.5 Ensembl ENCODE dbSUPER 46.7 +539.2 539223 2 FEZF1 GLI4 ZNF2 ZNF121 ZNF416 KLF7 ZNF548 ATF7 ZNF202 SP3 ZNF518A TCTN3 MMS19 CCNJ LCOR EXOSC1 NPM1P26 TM9SF3 MIR607 ALDH18A1
GH10H096128 1.1 ENCODE 30.8 +88.7 88683 3 HDGF ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF143 ZNF518A CCNJ LCOR NPM1P26 TCTN3 RPL13AP5 TM9SF3 SLIT1-AS1 ENTPD1-AS1 GC10M096129
GH10H096642 1.1 ENCODE dbSUPER 22.7 +599.6 599629 0 ATF1 ZSCAN4 ARID4B RAD21 CHAMP1 EGR1 RUNX3 CREM MCM3 TGIF2 TCTN3 ZNF518A CCNJ LCOR EXOSC1 NPM1P26 PIK3AP1 MIR607 MMS19 TM9SF3
GH10H096640 1.1 ENCODE dbSUPER 22.7 +599.3 599285 0 ATF1 ZSCAN4 ARID4B RAD21 CHAMP1 EGR1 ZNF143 RUNX3 CREM EGR2 TCTN3 ZNF518A CCNJ EXOSC1 NPM1P26 MMS19 TM9SF3 RPL13AP5 LCOR ZDHHC16
GH10H096670 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +632.4 632374 8 HDGF PKNOX1 FOXA2 MLX ARID4B YY1 TCF12 ZNF207 RUNX3 MCM3 PIK3AP1 NPM1P26 TCTN3 TM9SF3 RPL13AP5 CCNJ EXOSC1 LCOR GC10M096631
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNJ on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNJ Gene

Chromosome:
10
Start:
96,041,774 bp from pter
End:
96,060,870 bp from pter
Size:
19,097 bases
Orientation:
Plus strand

Genomic View for CCNJ Gene

Genes around CCNJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNJ Gene

Proteins for CCNJ Gene

  • Protein details for CCNJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T5M9-CCNJ_HUMAN
    Recommended name:
    Cyclin-J
    Protein Accession:
    Q5T5M9
    Secondary Accessions:
    • B7Z4E7
    • Q86XL1
    • Q9NV69

    Protein attributes for CCNJ Gene

    Size:
    372 amino acids
    Molecular mass:
    42581 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91887.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNJ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNJ Gene

Post-translational modifications for CCNJ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNJ Gene

Domains & Families for CCNJ Gene

Gene Families for CCNJ Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCNJ Gene

Suggested Antigen Peptide Sequences for CCNJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T5M9

UniProtKB/Swiss-Prot:

CCNJ_HUMAN :
  • Belongs to the cyclin family.
Family:
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNJ: view

Function for CCNJ Gene

Phenotypes From GWAS Catalog for CCNJ Gene

genes like me logo Genes that share phenotypes with CCNJ: view

Animal Model Products

CRISPR Products

miRNA for CCNJ Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCNJ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNJ Gene

Localization for CCNJ Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNJ gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CCNJ: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNJ Gene

Pathways & Interactions for CCNJ Gene

No Data Available

Interacting Proteins for CCNJ Gene

Gene Ontology (GO) - Biological Process for CCNJ Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCNJ Gene

Drugs & Compounds for CCNJ Gene

No Compound Related Data Available

Transcripts for CCNJ Gene

Unigene Clusters for CCNJ Gene

Cyclin J:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCNJ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCNJ Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: -
SP3:
SP4:
SP5: - -

Relevant External Links for CCNJ Gene

GeneLoc Exon Structure for
CCNJ
ECgene alternative splicing isoforms for
CCNJ

Expression for CCNJ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNJ Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNJ Gene:

CCNJ

SOURCE GeneReport for Unigene cluster for CCNJ Gene:

Hs.596479

Evidence on tissue expression from TISSUES for CCNJ Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CCNJ: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNJ Gene

Orthologs for CCNJ Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNJ 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia CCNJ 33 34
  • 93.56 (n)
oppossum
(Monodelphis domestica)
Mammalia CCNJ 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNJ 33 34
  • 92.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNJ 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnj 33
  • 87.77 (n)
mouse
(Mus musculus)
Mammalia Ccnj 33 16 34
  • 87.25 (n)
chicken
(Gallus gallus)
Aves CCNJ 33 34
  • 78.57 (n)
lizard
(Anolis carolinensis)
Reptilia CCNJ 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnj 33
  • 71.03 (n)
Str.1408 33
zebrafish
(Danio rerio)
Actinopterygii LOC557593 33
  • 66.48 (n)
CCNJ 34
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycJ 34
  • 22 (a)
OneToMany
Species where no ortholog for CCNJ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNJ Gene

ENSEMBL:
Gene Tree for CCNJ (if available)
TreeFam:
Gene Tree for CCNJ (if available)

Paralogs for CCNJ Gene

Paralogs for CCNJ Gene

(1) SIMAP similar genes for CCNJ Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CCNJ Gene

genes like me logo Genes that share paralogs with CCNJ: view

Variants for CCNJ Gene

Sequence variations from dbSNP and Humsavar for CCNJ Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000079410 -- 96,042,949(+) AAGGA(A/G)GGGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000187916 -- 96,051,560(+) GAGTA(C/T)GTAGA intron-variant
rs1000237337 -- 96,060,271(+) AACAA(C/T)AGCCA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000296120 -- 96,042,755(+) GGTTT(C/T)CTCTA intron-variant, upstream-variant-2KB
rs1000391610 -- 96,042,390(+) CTGCC(A/G)ACTTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCNJ Gene

Variant ID Type Subtype PubMed ID
esv3579077 CNV loss 25503493
nsv1110852 OTHER inversion 24896259
nsv825529 CNV loss 20364138

Variation tolerance for CCNJ Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNJ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNJ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNJ Gene

Disorders for CCNJ Gene

Relevant External Links for CCNJ

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNJ

No disorders were found for CCNJ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNJ Gene

Publications for CCNJ Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer. (PMID: 26469956) Sun X … Hu T (Cell death & disease 2015) 3 60
  5. CCNJ detected by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma. (PMID: 25672416) Takano N … Nomoto S (International journal of oncology 2015) 3 60

Products for CCNJ Gene

Sources for CCNJ Gene

Content
Loading form....