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CCNJ Gene

protein-coding   GIFtS: 42
GCID: GC10P097793

Cyclin J

  Search for CCNJ
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin J1 2
bA690P14.12
cyclin-J2

External Ids:    HGNC: 234341   Entrez Gene: 546192   Ensembl: ENSG000001074437   UniProtKB: Q5T5M93   

Export aliases for CCNJ gene to outside databases

Previous GC identifers: GC10P097468 GC10P091430


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCNJ Gene:
CCNJ (cyclin J) is a protein-coding gene. An important paralog of this gene is CCNJL.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNJ gene promoter:
         AhR   MyoD   Tal-1beta   RORalpha2   Chx10   STAT3   c-Myb   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNJ promoter sequence
   Search Chromatin IP Primers for CCNJ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNJ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23.33

CCNJ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNJ gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P097793:  view genomic region     (about GC identifiers)

Start:
97,803,151 bp from pter      End:
97,820,627 bp from pter
Size:
17,477 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCNJ_HUMAN, Q5T5M9 (See protein sequence)
Recommended Name: Cyclin-J  
Size: 372 amino acids; 42581 Da
Sequence caution: Sequence=BAA91887.1; Type=Erroneous initiation;
Secondary accessions: B7Z4E7 Q86XL1 Q9NV69
Alternative splicing: 3 isoforms:  Q5T5M9-1   Q5T5M9-2   Q5T5M9-3   

Explore the universe of human proteins at neXtProt for CCNJ: NX_Q5T5M9

Explore proteomics data for CCNJ at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCNJ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001127847.1  NP_001127848.1  NP_061957.2  

    ENSEMBL proteins: 
     ENSP00000384498   ENSP00000265992   ENSP00000435373   ENSP00000441415  

    CCNJ Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR028859 Cyclin-J

    Graphical View of Domain Structure for InterPro Entry Q5T5M9

    ProtoNet protein and cluster: Q5T5M9

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNJ_HUMAN, Q5T5M9
    Similarity: Belongs to the cyclin family
    Similarity: Contains 1 cyclin N-terminal domain


    CCNJ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNJ
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    Block miRNA regulation of human, mouse, rat CCNJ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNJ (see all 97):
    hsa-miR-520e hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-146a hsa-miR-128 hsa-miR-93 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCCNJ 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CCNJ for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCNJ
    Interactions:

        Search GeneGlobe Interaction Network for CCNJ

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNJ



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCNJ gene (3 alternative transcripts): 
    NM_001134375.1  NM_001134376.1  NM_019084.4  

    Unigene Cluster for CCNJ:

    Cyclin J
    Hs.596479  [show with all ESTs]
    Unigene Representative Sequence: NM_001134375
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403870 ENST00000265992(uc001klm.3 uc001kln.3) ENST00000465148
    ENST00000534974
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    hsa-miR-520e hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-146a hsa-miR-128 hsa-miR-93 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCCNJ 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK001757.1 AK025932.1 AK092360.1 AK297264.1 AK303018.1 BC043175.1 

    7 DOTS entries:

    DT.101959871  DT.100687932  DT.100779502  DT.100779503  DT.206829  DT.100658286  DT.91798460 

    Selected AceView cDNA sequences (see all 64):

    BM716702 C20801 CR607594 BM784745 BU507922 AU133451 AA961466 AK025932 
    BU738456 BM789816 BM712849 CB105424 AW377123 N36090 BX431213 AU129043 
    T16093 BX420301 AI360364 BU601468 AW451926 AK001757 AU131647 AU154786 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNJ    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                  -                     
    SP2:                                                  -                     
    SP3:                                                                        
    SP4:                                                                        
    SP5:        -     -                                                         


    ECgene alternative splicing isoforms for CCNJ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNJ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATTGTTT
    CCNJ Expression
    About this image

    CCNJ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNJ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.596479
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCNJ gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnj1 , 5 cyclin J1, 5 87.25(n)1
    96.57(a)1
      19 (34.26 cM)5
    2406651  NM_172839.41  NP_766427.11 
     408312795 
    chicken
    (Gallus gallus)
    Aves CCNJ1 cyclin J 78.57(n)
    85.04(a)
      423821  XM_003641518.2  XP_003641566.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNJ6
    cyclin J
    84(a)
    1 ↔ 1
    GL343262.1(1465667-1486172)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.14082 Transcribed sequence with moderate similarity to protein more 78.31(n)    137720578 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5575931 cyclin-J-like 66.48(n)
    70.09(a)
      557593  XM_005173036.1  XP_005173093.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycJ6
    Cyclin J
    22(a)
    1 → many
    3L(3466414-3468098)


    ENSEMBL Gene Tree for CCNJ (if available)
    TreeFam Gene Tree for CCNJ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNJ gene
    CCNJL2  
    1 SIMAP similar gene for CCNJ using alignment to 2 protein entries:     CCNJ_HUMAN (see all proteins):
    CCNJL

    CCNJ for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CCNJ
    PGOHUM00000244798 PGOHUM00000232713


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCNJ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825529CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNJ gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCNJ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    9. Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions. (PubMed id 19591820)9 Althoff F....Lehner C.F. (Dev. Biol. 2009)
    10. A role for cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis. (PubMed id 11071782)9 Kolonin M.G. and Finley R.L. (Dev. Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54619 HGNC: 23434 AceView: CCNJ Ensembl:ENSG00000107443 euGenes: HUgn54619
    ECgene: CCNJ H-InvDB: CCNJ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNJ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNJ gene:
    Search GeneIP for patents involving CCNJ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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