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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNI2 Gene

protein-coding   GIFtS: 36
GCID: GC05P132112

Cyclin I Family, Member 2

  Search for CCNI2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin I Family, Member 21 2
cyclin-I22

External Ids:    HGNC: 338691   Entrez Gene: 6451212   Ensembl: ENSG000002050897   UniProtKB: Q6ZMN83   

Export aliases for CCNI2 gene to outside databases

Previous GC identifer: GC05P127275


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCNI2 Gene: 
CCNI2 (cyclin I family, member 2) is a protein-coding gene. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNG1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNI2 gene promoter:
         AhR   TBP   SRF   Sox5   SRF (504 AA)   MEF-2A   HEN1   AREB6   COMP1   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CCNI2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

CCNI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNI2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P132112:  view genomic region     (about GC identifiers)

Start:
132,083,137 bp from pter      End:
132,089,856 bp from pter
Size:
6,720 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNI2_HUMAN, Q6ZMN8 (See protein sequence)
Recommended Name: Cyclin-I2  
Size: 369 amino acids; 40622 Da
Secondary accessions: B2RNE2

Explore the universe of human proteins at neXtProt for CCNI2: NX_Q6ZMN8

Explore proteomics data for CCNI2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZMN8

  • CCNI2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNI2 Protein Expression
    REFSEQ proteins: NP_001034869.1  
    ENSEMBL proteins: 
     ENSP00000368005  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry Q6ZMN8

    ProtoNet protein and cluster: Q6ZMN8

    UniProtKB/Swiss-Prot: CCNI2_HUMAN, Q6ZMN8
    Similarity: Belongs to the cyclin family


    CCNI2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IEA--
         
    CCNI2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCNI2

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0051726regulation of cell cycle ----

    CCNI2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about CCNI2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for CCNI2 gene: 
    NM_001039780.2  

    Unigene Cluster for CCNI2:

    Cyclin I family, member 2
    Hs.714496  [show with all ESTs]
    Unigene Representative Sequence: AK131553
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378731(uc003kxq.1 uc011cxg.1 uc011cxh.1) ENST00000492179
    ENST00000468733
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    Additional mRNA sequence: 

    AK131553.1 BC132837.1 BC136836.1 BC144416.1 BC144417.1 

    4 DOTS entries:

    DT.120876759  DT.40303743  DT.91955824  DT.120876765 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTGGGAGG
    CCNI2 Expression
    About this image


    See CCNI2 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.714496
        SABiosciences Custom PCR Arrays for CCNI2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCNI2 gene from 5/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CCNI26
    cyclin I family, member 2
    77(a)
    1 ↔ 1
    11(21050176-21054922)
    chicken
    (Gallus gallus)
    Aves CCNI26
    cyclin I family, member 2
    37(a)
    1 ↔ 1
    13(16302773-16308299)
    lizard
    (Anolis carolinensis)
    Reptilia CCNI26
    cyclin I family, member 2
    37(a)
    1 ↔ 1
    2(127551568-127565606)
    zebrafish
    (Danio rerio)
    Actinopterygii ccni26
    cyclin I family, member 2
    37(a)
    1 ↔ 1
    21(41785656-41803900)
    fruit fly
    (Drosophila melanogaster)
    Insecta CycG6
    Cyclin G
    11(a)
    1 → many
    3R(27422364-27438386)


    ENSEMBL Gene Tree for CCNI2 (if available)
    TreeFam Gene Tree for CCNI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNI2 gene
    CCNG12  CCNG22  CCNI2  
    1 SIMAP similar gene for CCNI2 using alignment to 3 protein entries:     CCNI2_HUMAN (see all proteins):
    CCNI

    CCNI2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/98 SNPs in CCNI2 are shown (see all 98)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs68853481,2
    C,F,A--132081164(+) GATTTC/TCTGCA 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1120865731,2
    F--132081186(+) ACTTTC/TATTTT 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1444427631,2
    --132081263(+) CACAGC/TACCCC 1 -- us2k10--------
    rs1390886281,2
    --132081305(+) TCCCCA/GCTCTG 1 -- us2k10--------
    rs68858491,2
    C,F,H--132081403(+) ctgttC/Tctgtg 1 -- us2k17Minor allele frequency- T:0.08NS NA WA 1010
    rs797572541,2
    C,F--132081465(+) GACATG/TATTTC 1 -- us2k14Minor allele frequency- T:0.14NA EA 244
    rs68858651,2
    C,F,A--132081487(+) tgactA/Gcatag 1 -- us2k16Minor allele frequency- G:0.34NA WA CSA 128
    rs1440642681,2
    --132081507(+) TTGTAC/TATGTA 1 -- us2k10--------
    rs1464500251,2
    --132081547(+) AAGGGC/TACCTA 1 -- us2k10--------
    rs1410418001,2
    --132081588(+) AGTACC/TGTGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNI2 (132083137 - 132089856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CCNI2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv529021CNV Loss19592680
    nsv882918CNV Loss21882294
    nsv528687CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNI2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCNI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 645121 HGNC: 33869 Ensembl:ENSG00000205089 euGenes: HUgn645121 ECgene: CCNI2
    H-InvDB: CCNI2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNI2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNI2 gene:
    Search GeneIP for patents involving CCNI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Antibodies for CCNI2
     See all of Abcam's Antibodies, Kits and Proteins for CCNI2
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CCNI2
     Antibodies for CCNI2
     ELISAs for CCNI2
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     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNI2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CCNI2
     Browse SwitchGear Promoter luciferase reporter plasmids for CCNI2
     Search ThermoFisher Antibodies for CCNI2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNI2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNI2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNI2
    Customized:
     lentivirus for stable overexpression of CCNI2
     lentivirus expression plasmids for stable overexpression of CCNI2
     adenovirus for overexpression of CCNI2
     LSBio Antibodies in human, mouse, rat for CCNI2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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