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Aliases for CCNI2 Gene

Aliases for CCNI2 Gene

  • Cyclin I Family Member 2 2 3 5
  • Cyclin I Family, Member 2 2

External Ids for CCNI2 Gene

Previous GeneCards Identifiers for CCNI2 Gene

  • GC05P132112
  • GC05P127275

Summaries for CCNI2 Gene

GeneCards Summary for CCNI2 Gene

CCNI2 (Cyclin I Family Member 2) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNI.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNI2 Gene

Genomics for CCNI2 Gene

Regulatory Elements for CCNI2 Gene

Promoters for CCNI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNI2 Gene

Chromosome:
5
Start:
132,747,411 bp from pter
End:
132,756,255 bp from pter
Size:
8,845 bases
Orientation:
Plus strand

Genomic View for CCNI2 Gene

Genes around CCNI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNI2 Gene

Proteins for CCNI2 Gene

  • Protein details for CCNI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMN8-CCNI2_HUMAN
    Recommended name:
    Cyclin-I2
    Protein Accession:
    Q6ZMN8
    Secondary Accessions:
    • B2RNE2
    • B7ZMB7
    • B7ZMB8

    Protein attributes for CCNI2 Gene

    Size:
    369 amino acids
    Molecular mass:
    40622 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNI2 Gene

Proteomics data for CCNI2 Gene at MOPED

Post-translational modifications for CCNI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNI2 Gene

No data available for DME Specific Peptides for CCNI2 Gene

Domains & Families for CCNI2 Gene

Gene Families for CCNI2 Gene

Protein Domains for CCNI2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNI2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMN8

UniProtKB/Swiss-Prot:

CCNI2_HUMAN :
  • Belongs to the cyclin family.
Family:
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNI2: view

Function for CCNI2 Gene

Phenotypes for CCNI2 Gene

GenomeRNAi human phenotypes for CCNI2:
genes like me logo Genes that share phenotypes with CCNI2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCNI2 Gene

Localization for CCNI2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNI2 Gene COMPARTMENTS Subcellular localization image for CCNI2 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCNI2 Gene

Pathways & Interactions for CCNI2 Gene

SuperPathways for CCNI2 Gene

No Data Available

Interacting Proteins for CCNI2 Gene

Gene Ontology (GO) - Biological Process for CCNI2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCNI2 Gene

Drugs & Compounds for CCNI2 Gene

No Compound Related Data Available

Transcripts for CCNI2 Gene

mRNA/cDNA for CCNI2 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCNI2 Gene

Cyclin I family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNI2 Gene

No ASD Table

Relevant External Links for CCNI2 Gene

GeneLoc Exon Structure for
CCNI2
ECgene alternative splicing isoforms for
CCNI2

Expression for CCNI2 Gene

mRNA expression in normal human tissues for CCNI2 Gene

SOURCE GeneReport for Unigene cluster for CCNI2 Gene Hs.714496

genes like me logo Genes that share expression patterns with CCNI2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCNI2 Gene

Orthologs for CCNI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNI2 35
  • 99.1 (n)
  • 98.64 (a)
CCNI2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNI2 36
  • 61 (a)
OneToOne
CCNI2 35
  • 75.14 (n)
  • 64.8 (a)
dog
(Canis familiaris)
Mammalia CCNI2 35
  • 86.99 (n)
  • 79.28 (a)
CCNI2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNI2 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNI2 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNI2 36
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccni2 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycG 36
  • 11 (a)
OneToMany
Species with no ortholog for CCNI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNI2 Gene

ENSEMBL:
Gene Tree for CCNI2 (if available)
TreeFam:
Gene Tree for CCNI2 (if available)

Paralogs for CCNI2 Gene

Paralogs for CCNI2 Gene

(1) SIMAP similar genes for CCNI2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCNI2: view

Variants for CCNI2 Gene

Sequence variations from dbSNP and Humsavar for CCNI2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs803056 - 132,747,766(-) GACCG(C/G)GTCTG reference, missense
rs803057 -- 132,746,205(-) acaag(C/T)ggtca upstream-variant-2KB
rs2009357 -- 132,749,836(-) ACCAG(C/T)TTCAT intron-variant
rs6885849 -- 132,745,711(+) ctgtt(C/T)ctgtg upstream-variant-2KB
rs6885865 -- 132,745,795(+) tgact(A/G)catag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCNI2 Gene

Variant ID Type Subtype PubMed ID
nsv529021 CNV Loss 19592680
nsv882918 CNV Loss 21882294
nsv528687 CNV Gain 19592680

Variation tolerance for CCNI2 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNI2 Gene

HapMap Linkage Disequilibrium report
CCNI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNI2 Gene

Disorders for CCNI2 Gene

Relevant External Links for CCNI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNI2

No disorders were found for CCNI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNI2 Gene

Publications for CCNI2 Gene

  1. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. (PMID: 23707792) Taneera J. … Groop L. (Mol. Cell. Endocrinol. 2013) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CCNI2 Gene

Sources for CCNI2 Gene

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