Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCNI2 Gene

Aliases for CCNI2 Gene

  • Cyclin I Family Member 2 2 3 5
  • Cyclin I Family, Member 2 2
  • Cyclin-I2 3

External Ids for CCNI2 Gene

Previous GeneCards Identifiers for CCNI2 Gene

  • GC05P132112
  • GC05P127275

Summaries for CCNI2 Gene

GeneCards Summary for CCNI2 Gene

CCNI2 (Cyclin I Family Member 2) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNI.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNI2 Gene

Genomics for CCNI2 Gene

Regulatory Elements for CCNI2 Gene

Enhancers for CCNI2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F132770 1.3 Ensembl ENCODE 12.5 +27.1 27092 7.9 HDGF PKNOX1 ARID4B SIN3A ZNF48 YY1 GLIS2 CBX5 GATA2 ZNF143 SEPT8 CCNI2 KIF3A RAD50 ENSG00000224431 SOWAHA SHROOM1 TH2LCRR IL13 IL4
GH05F132767 1.2 Ensembl ENCODE 12 +20.6 20579 1.6 ATF1 PKNOX1 ARNT CREB3L1 ZNF766 GATA2 FOS JUNB NCOA1 TBX21 SEPT8 CCNI2 KIF3A SHROOM1 SOWAHA TH2LCRR IL4 RNU7-15P RNA5SP192 ENSG00000230612
GH05F132818 1.2 Ensembl ENCODE 10.7 +72.4 72392 2.2 ELF3 HDAC1 CBX3 ATF1 TBL1XR1 WRNIP1 ARID4B ZNF2 RAD21 YY1 GDF9 RNU7-15P RNA5SP192 UQCRQ CCNI2 KIF3A IL4 ENSG00000230612 SHROOM1 ENSG00000272203
GH05F132812 0.9 ENCODE 11 +68.2 68192 5.4 CBX3 YY1 GLIS2 EGR2 ZNF202 ZNF263 ZNF362 ZNF280D CEBPB ZEB2 IL4 GDF9 RAD50 AFF4 RNU7-15P RNA5SP192 CCNI2 UQCRQ KIF3A ZCCHC10
GH05F132788 0.8 ENCODE 10.8 +41.5 41524 1.7 BCOR HDAC1 LEF1 ZNF146 PKNOX1 TBL1XR1 TAL1 NFRKB ZMYM3 ZIC2 SEPT8 SOWAHA SHROOM1 CCNI2 KIF3A RNU7-15P RNA5SP192 ENSG00000230612 LEAP2 GC05M132776
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNI2 on UCSC Golden Path with GeneCards custom track

Promoters for CCNI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CCNI2 Gene

132,747,411 bp from pter
132,756,255 bp from pter
8,845 bases
Plus strand

Genomic View for CCNI2 Gene

Genes around CCNI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNI2 Gene

Proteins for CCNI2 Gene

  • Protein details for CCNI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RNE2
    • B7ZMB7
    • B7ZMB8

    Protein attributes for CCNI2 Gene

    369 amino acids
    Molecular mass:
    40622 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNI2 Gene


neXtProt entry for CCNI2 Gene

Post-translational modifications for CCNI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNI2 Gene

No data available for DME Specific Peptides for CCNI2 Gene

Domains & Families for CCNI2 Gene

Gene Families for CCNI2 Gene

Protein Domains for CCNI2 Gene


Suggested Antigen Peptide Sequences for CCNI2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family.
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNI2: view

Function for CCNI2 Gene

Phenotypes for CCNI2 Gene

GenomeRNAi human phenotypes for CCNI2:
genes like me logo Genes that share phenotypes with CCNI2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCNI2 Gene

Localization for CCNI2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNI2 gene
Compartment Confidence
nucleus 3
peroxisome 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCNI2 Gene

Pathways & Interactions for CCNI2 Gene

SuperPathways for CCNI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNI2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCNI2 Gene

Transcripts for CCNI2 Gene

mRNA/cDNA for CCNI2 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCNI2 Gene

Cyclin I family, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNI2 Gene

No ASD Table

Relevant External Links for CCNI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCNI2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNI2 Gene:


SOURCE GeneReport for Unigene cluster for CCNI2 Gene:

genes like me logo Genes that share expression patterns with CCNI2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCNI2 Gene

Orthologs for CCNI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCNI2 34 35
  • 99.1 (n)
(Canis familiaris)
Mammalia CCNI2 34 35
  • 86.99 (n)
(Bos Taurus)
Mammalia CCNI2 34 35
  • 75.14 (n)
(Ornithorhynchus anatinus)
Mammalia CCNI2 35
  • 36 (a)
(Gallus gallus)
Aves CCNI2 35
  • 37 (a)
(Anolis carolinensis)
Reptilia CCNI2 35
  • 38 (a)
(Danio rerio)
Actinopterygii ccni2 35
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycG 35
  • 11 (a)
Species where no ortholog for CCNI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNI2 Gene

Gene Tree for CCNI2 (if available)
Gene Tree for CCNI2 (if available)

Paralogs for CCNI2 Gene

Paralogs for CCNI2 Gene

(1) SIMAP similar genes for CCNI2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCNI2: view

Variants for CCNI2 Gene

Sequence variations from dbSNP and Humsavar for CCNI2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10042315 -- 132,753,983(+) TTTGG(G/T)GTGTT intron-variant, utr-variant-3-prime
rs10042319 -- 132,753,985(+) tGGTG(G/T)GTTTG intron-variant, utr-variant-3-prime
rs10520113 -- 132,750,693(-) GCTAT(C/G)TGTCA intron-variant, downstream-variant-500B
rs111234856 -- 132,751,724(+) TTTCC(A/G)CTCAT intron-variant, utr-variant-3-prime
rs111400635 -- 132,748,071(+) GATCC(A/G)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNI2 Gene

Variant ID Type Subtype PubMed ID
nsv529021 CNV loss 19592680
nsv528687 CNV gain 19592680
esv3606809 CNV gain 21293372

Variation tolerance for CCNI2 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNI2 Gene

Disorders for CCNI2 Gene

Relevant External Links for CCNI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCNI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNI2 Gene

Publications for CCNI2 Gene

  1. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. (PMID: 23707792) Taneera J. … Groop L. (Mol. Cell. Endocrinol. 2013) 2 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CCNI2 Gene

Sources for CCNI2 Gene

Loading form....