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Aliases for CCNI Gene

Aliases for CCNI Gene

  • Cyclin I 2 3 5
  • Cyclin ITI 3
  • Cyclin-I 3
  • CCNI1 3
  • CYC1 3
  • CYI 3

External Ids for CCNI Gene

Previous GeneCards Identifiers for CCNI Gene

  • GC04M077878
  • GC04M078159
  • GC04M078361
  • GC04M078427
  • GC04M078326
  • GC04M077968
  • GC04M073720

Summaries for CCNI Gene

Entrez Gene Summary for CCNI Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]

GeneCards Summary for CCNI Gene

CCNI (Cyclin I) is a Protein Coding gene. Diseases associated with CCNI include Epilepsy, Familial Temporal Lobe, 3. An important paralog of this gene is CCNI2.

Gene Wiki entry for CCNI Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNI Gene

Genomics for CCNI Gene

Regulatory Elements for CCNI Gene

Enhancers for CCNI Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G077052 0.9 ENCODE dbSUPER 12.9 +23.6 23550 0.7 BCOR CTCF PKNOX1 ZNF146 CEBPB REST CEBPG RAD21 SMARCA4 SCRT2 CCNI SEPT11 GC04M077051 GC04P077075
GH04G077174 0.8 ENCODE dbSUPER 12 -99.2 -99206 1.2 ZNF585B BCL11A POLR2A TEAD4 MAX CHD7 EZH2 CCNI CCNG2 FTLP9
GH04G077171 0.8 ENCODE dbSUPER 12 -96.2 -96200 2.4 HDAC2 BHLHE40 POU5F1 FOS CHD7 NFE2L2 CCNI CCNG2 FTLP9
GH04G077176 0.8 ENCODE dbSUPER 12 -101.8 -101832 3.0 ZNF316 POLR2A SMARCA4 MAFK EZH2 NR2F2 CCNI CCNG2 FTLP9
GH04G077053 0.6 FANTOM5 dbSUPER 14 +22.5 22457 0.4 CCNI SEPT11 GC04M077051 GC04P077075
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNI on UCSC Golden Path with GeneCards custom track

Promoters for CCNI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000169595 813 3601 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3

Genomic Location for CCNI Gene

Chromosome:
4
Start:
77,047,155 bp from pter
End:
77,076,013 bp from pter
Size:
28,859 bases
Orientation:
Minus strand

Genomic View for CCNI Gene

Genes around CCNI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNI Gene

Proteins for CCNI Gene

  • Protein details for CCNI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14094-CCNI_HUMAN
    Recommended name:
    Cyclin-I
    Protein Accession:
    Q14094
    Secondary Accessions:
    • B2R6M0
    • B7Z6X4

    Protein attributes for CCNI Gene

    Size:
    377 amino acids
    Molecular mass:
    42557 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNI Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNI Gene

Post-translational modifications for CCNI Gene

  • Ubiquitination at posLast=22 and posLast=1818
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCNI Gene

Domains & Families for CCNI Gene

Gene Families for CCNI Gene

Protein Domains for CCNI Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNI Gene

Graphical View of Domain Structure for InterPro Entry

Q14094

UniProtKB/Swiss-Prot:

CCNI_HUMAN :
  • Belongs to the cyclin family.
Family:
  • Belongs to the cyclin family.
genes like me logo Genes that share domains with CCNI: view

Function for CCNI Gene

genes like me logo Genes that share phenotypes with CCNI: view

Animal Models for CCNI Gene

MGI Knock Outs for CCNI:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNI Gene

Localization for CCNI Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNI gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCNI Gene

Pathways & Interactions for CCNI Gene

No Data Available

Pathways by source for CCNI Gene

1 GeneTex pathway for CCNI Gene

Gene Ontology (GO) - Biological Process for CCNI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis NAS 9705831
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CCNI: view

No data available for SIGNOR curated interactions for CCNI Gene

Drugs & Compounds for CCNI Gene

No Compound Related Data Available

Transcripts for CCNI Gene

Unigene Clusters for CCNI Gene

Cyclin I:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNI Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c
SP1: - -
SP2: - - - -
SP3: -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7:
SP8: -
SP9: - - - -

Relevant External Links for CCNI Gene

GeneLoc Exon Structure for
CCNI
ECgene alternative splicing isoforms for
CCNI

Expression for CCNI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNI Gene

This gene is overexpressed in Bone (56.5) and Pancreas (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNI Gene



Protein tissue co-expression partners for CCNI Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNI Gene:

CCNI

SOURCE GeneReport for Unigene cluster for CCNI Gene:

Hs.518827

mRNA Expression by UniProt/SwissProt for CCNI Gene:

Q14094-CCNI_HUMAN
Tissue specificity: Highest levels in adult heart, brain and skeletal muscle. Lower levels in adult placenta, lung, kidney and pancreas. Also high levels in fetal brain and lower levels in fetal lung, liver and kidney. Also abundant in testis and thyroid.

Evidence on tissue expression from TISSUES for CCNI Gene

  • Nervous system(4.9)
  • Kidney(4.7)
  • Muscle(4.5)
  • Spleen(4.4)
  • Eye(4.1)
  • Lung(3.8)
  • Pancreas(3)
  • Skin(2.8)
  • Intestine(2.7)
  • Heart(2.5)
  • Stomach(2.4)
  • Thyroid gland(2.2)
  • Liver(2.1)
  • Blood(2)
  • Gall bladder(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CCNI: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNI Gene

Orthologs for CCNI Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNI 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia CCNI 34 35
  • 94.96 (n)
cow
(Bos Taurus)
Mammalia CCNI 34 35
  • 93.72 (n)
mouse
(Mus musculus)
Mammalia Ccni 34 16 35
  • 92.75 (n)
rat
(Rattus norvegicus)
Mammalia Ccni 34
  • 92.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CCNI 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNI 34 35
  • 79.49 (n)
lizard
(Anolis carolinensis)
Reptilia CCNI 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccni 34
  • 71.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68660 34
zebrafish
(Danio rerio)
Actinopterygii ccni 34 35
  • 63.19 (n)
Dr.10085 34
fruit fly
(Drosophila melanogaster)
Insecta CycG 35
  • 12 (a)
OneToMany
Species where no ortholog for CCNI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNI Gene

ENSEMBL:
Gene Tree for CCNI (if available)
TreeFam:
Gene Tree for CCNI (if available)

Paralogs for CCNI Gene

Paralogs for CCNI Gene

(3) SIMAP similar genes for CCNI Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CCNI: view

Variants for CCNI Gene

Sequence variations from dbSNP and Humsavar for CCNI Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000115 -- 77,069,590(+) ccccc(C/T)ccccc intron-variant
rs1000044096 -- 77,066,034(+) AGGCA(A/G)GGGTT intron-variant
rs1000098133 -- 77,050,681(+) AAAAG(G/T)TAACA intron-variant
rs1000136644 -- 77,075,572(+) TCTCA(C/T)AGGCG utr-variant-5-prime
rs1000213747 -- 77,069,080(+) TTCTT(C/T)AATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNI Gene

Variant ID Type Subtype PubMed ID
nsv1073775 CNV deletion 25765185
nsv7363 OTHER inversion 18451855

Variation tolerance for CCNI Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNI Gene

Disorders for CCNI Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCNI Gene - From: DISEASES

Disorder Aliases PubMed IDs
epilepsy, familial temporal lobe, 3
  • familial temporal lobe epilepsy 3
- elite association - COSMIC cancer census association via MalaCards
Search CCNI in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNI

Genetic Association Database (GAD)
CCNI
Human Genome Epidemiology (HuGE) Navigator
CCNI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNI
genes like me logo Genes that share disorders with CCNI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNI Gene

Publications for CCNI Gene

  1. Cyclin I: a new cyclin encoded by a gene isolated from human brain. (PMID: 7493655) Nakamura T. … Mori N. (Exp. Cell Res. 1995) 2 3 4 22 64
  2. Expression of a novel isoform of cyclin I in human testis. (PMID: 9705831) Zhu X. … Naz R.K. (Biochem. Biophys. Res. Commun. 1998) 3 4 22 64
  3. Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. (PMID: 17507299) Sun Z.L. … Miao Y. (Biochim. Biophys. Acta 2007) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3 64

Products for CCNI Gene

Sources for CCNI Gene

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