CCNI Gene
protein-coding GIFtS : 50
GCID: GC04 M077968
cyclin I
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Aliasesfor CCNI gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cyclin I 1 2 CYC12 CYI2 Cyclin ITI2 Cyclin-I1
Export aliases for CCNI gene to outside databases Previous GC identifers: GC04M077878 GC04M078159 GC04M078361 GC04M078427 GC04M078326 GC04M073720
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Summariesfor CCNI gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CCNI : The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined. (provided by RefSeq, Jul 2008) Gene Wiki entry for CCNI
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Genomic Viewsfor CCNI gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CCNI gene promoter: COUP-TF1 STAT5B NCX/Ncx COUP HNF-4alpha2 Nkx2-5 HNF-4alpha1 C/EBPalpha COUP-TF STAT3 Other transcription factors Search SABiosciences Chromatin IP Primers for CCNI Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CCNI
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q21.1 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21.1 CCNI Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M077968: view genomic region
(about GC identifiers )
Start:
77,968,311 bp from pter
End:
77,997,158 bp from pter
Size:
28,848 bases
Orientation:
minus strand
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Proteinsfor CCNI gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CCNI_HUMAN, Q14094 (See
protein sequence )Recommended Name: Cyclin-I Size : 377 amino acids; 42557 Da
Developmental stage : Expression is independent of the cell cycle in lung fibroblasts
Secondary accessions : B2R6M0Explore the universe of human proteins at neXtProt for CCNI: NX_Q14094 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q14094 CCNI Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_006826.1 ENSEMBL proteins: ENSP00000237654 ENSP00000425935 ENSP00000425360 ENSP00000426467 ENSP00000426235 ENSP00000421594 ENSP00000441001 Human Recombinant Protein Products: CCNI Antibody Products: Assay Products for CCNI:
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Protein
Domains / Familiesfor CCNI gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CCNI for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q14094 ProtoNet protein and cluster: Q14094
1 Blocks protein family : IPB006670 Cyclin UniProtKB/Swiss-Prot: CCNI_HUMAN, Q14094 Similarity : Belongs to the cyclin family
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Functionfor CCNI gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCNI (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCNIOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCNI (NM_006835 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCNI Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCNI
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNI
1 GenomeRNAi human phenotype for CCNI :Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ccni) :
CCNI for phenotypes About GeneDecksing
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Pathways & Interactionsfor CCNI gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCNI STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/6 Interacting proteins for CCNI (Q14094 3 ENSP00000237654 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
CCNI for ontologies About GeneDecksing
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Drugs & Compoundsfor CCNI gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CCNI Search CenterWatch for drugs/clinical trials and news about CCNI
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Transcriptsfor CCNI gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for CCNI gene: NM_006835.2 Unigene Cluster for CCNI:
Cyclin I Hs.518827 [show with all ESTs ] Unigene Representative Sequence: NM_006835 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000237654 (uc003hkm.3 uc011ccb.2 ) ENST00000515468 ENST00000506614 ENST00000511943 ENST00000505609 ENST00000504697 ENST00000513774 ENST00000507788 ENST00000515790 ENST00000537948 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCNI (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCNIOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCNI (NM_006835 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCNI Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCNI
Additional cDNA sequence: AB209766.1 AF135162.1 AK222931.1 AK301111.1 AK312632.1 BC000420.2 BC004975.1 BT020019.1 CR541783.1 D50310.1
24/43 DOTS entries (see all 43 ): DT.100683449 DT.100683453
DT.92341872 DT.87024747 DT.96086522 DT.91885583 DT.95215327 DT.92324404 DT.100683446 DT.95215294 DT.121254591 DT.91854889 DT.95215287 DT.102839656 DT.92464873 DT.100683448 DT.100683445 DT.121254549 DT.121254885 DT.92464860 DT.95215296 DT.95215315 DT.95282406 DT.100683447 24/1180 AceView cDNA sequences (see all 1180 ):
AI879971 BQ672234 BU728494 CB155399 CN483826 BU784337 BM128012 BF940012 AA094874 AI097582 BM669562 BU187633 BF116238 AJ712254 D60574 AI681819 CK301014 CD512156 CA441689 AI611682 BU685664 BE393970 BU078719 AI582101 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CCNI (see all 9 ) About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c SP1 :           -       -                           SP2 :           -   -   -   -                           SP3 :                 -                           SP4 :           -   -   -   -   -                         SP5 :           -       -   -   -   -   -                  
ECgene alternative splicing isoforms for CCNI
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Expression for CCNI gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CCNI expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAAAATCAGG
About this image CCNI expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Endoderm-like cells (Generation of hepato... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CCNI Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CCNI SOURCE GeneReport for Unigene cluster: Hs.518827 UniProtKB/Swiss-Prot: CCNI_HUMAN, Q14094 Tissue specificity : Highest levels in adult heart, brain and skeletal muscle. Lower levels in adult placenta, lung,kidney and pancreas. Also high levels in fetal brain and lower levels in fetal lung, liver and kidney. Also abundant in testis and thyroid SABiosciences Custom PCR Arrays for CCNI Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCNIBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CCNI QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCNI QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCNI In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNI
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Orthologsfor CCNI gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CCNI gene from 4/13 species (see all 13 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
CCNI1
cyclin I
79.49(n) 81.43(a)
 
422634 XM_420590.3 XP_420590.1
lizard (Anolis carolinensis)
Reptilia
CCNI6
--
72(a)
1 ↔ 1
5(146220381-146241918)
African clawed frog (Xenopus laevis)
Amphibia
MGC686602
hypothetical protein MGC68660
76.72(n)
 
BC061670.1
zebrafish (Danio rerio)
Actinopterygii
Dr.100852
Danio rerio cDNA clone MGC55449 IMAGE2639743, complete more
77(n)
 
BC044400.1
ENSEMBL Gene Tree for CCNI (if available)TreeFam Gene Tree for CCNI (if available)
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Paralogsfor CCNI gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CCNI gene CCNI2 2 CCNG1 2 CCNG2 2 3 SIMAP similar genes for CCNI using alignment to 8 protein entries: CCNI_HUMAN (see all proteins ):CCNI2 CCNG1 CCNG2
CCNI for paralogs About GeneDecksing
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Genomic Variantsfor CCNI gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCNI
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Disorders
/ Diseasesfor CCNI gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CCNI for disorders About GeneDecksing 8 diseases for CCNI : About MalaCards temporal lobe epilepsy breast cancer pancreatic carcinoma pancreatitis schizophrenia thyroiditis carcinoma prostatitis 1 Novoseek disease relationship for CCNI gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer
6.28
1
15754132 (1)
Human Genome Epidemiology (HuGE) Navigator: CCNI (2 documents) Export disorders for CCNI gene to outside databases
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Publicationsfor CCNI gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CCNI gene, integrated from 9 sources (see all 18 ): (articles sorted by number of sources associating them with CCNI) Utopia : connect your pdf to the dynamic world of online information
Cyclin I: a new cyclin encoded by a gene isolated from human brain. (PubMed id 7493655) 1 , 2 , 3, 9 Nakamura T.... Mori N. (1995) Expression of a novel isoform of cyclin I in human testis. (PubMed id 9705831) 1 , 2 , 9 Zhu X. and Naz R.K. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. (PubMed id 17507299) 1 , 9 Sun Z.L....Miao Y. (2007) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677) 1 Camargo L.M....Brandon N.J. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CCNI gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CCNI gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CCNI gene
(According to HUGE )
About This Section --
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Specialized Databases showing CCNI gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CCNI Pharmacogenomics, SNPs, Pathways NIEHS-SNPs http://egp.gs.washington.edu/data/ccni/
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About This Section Patent Information for CCNI gene: Search GeneIP for patents involving CCNI GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CCNI gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CCNI OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CCNI OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCNI OriGene Protein Over-expression Lysate for CCNI Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CCNI OriGene 3'-UTR Clone for CCNI OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCNI OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCNI Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CCNI OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CCNI OriGene Custom Protein Services for CCNI OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCNI QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCNI QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CCNI QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CCNI QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCNI QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCNI
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CCNI Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNI
Search ThermoFisher Antibodies for CCNI
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCNI
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Aliases for CCNI
Databases for CCNI
Disorders / Diseases for CCNI
Domains / Families for CCNI
Drugs / Compounds for CCNI
Expression for CCNI
Function for CCNI
Genomic Views for CCNI
Intellectual Property for CCNI
Orthologs for CCNI
Paralogs for CCNI
Pathways / Interactions for CCNI
Products for CCNI
Proteins for CCNI
Publications for CCNI
Search Box for CCNI
Summaries for CCNI
Transcripts for CCNI
Variants for CCNI
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