Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CCNI Gene

protein-coding   GIFtS: 55
GCID: GC04M077968

Cyclin I

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cyclin I1 2
CYC12
CYI2
Cyclin ITI2
cyclin-I2

External Ids:    HGNC: 15951   Entrez Gene: 109832   Ensembl: ENSG000001188167   UniProtKB: Q140943   

Export aliases for CCNI gene to outside databases

Previous GC identifers: GC04M077878 GC04M078159 GC04M078361 GC04M078427 GC04M078326 GC04M073720


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CCNI Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of
this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not
yet been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNI Gene:
CCNI (cyclin I) is a protein-coding gene. An important paralog of this gene is CCNI2.

Gene Wiki entry for CCNI Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNI gene promoter:
         COUP-TF1   STAT5B   NCX/Ncx   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   C/EBPalpha   COUP-TF   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CCNI promoter sequence
   Search Chromatin IP Primers for CCNI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

CCNI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNI gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M077968:  view genomic region     (about GC identifiers)

Start:
77,968,311 bp from pter      End:
77,997,158 bp from pter
Size:
28,848 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CCNI_HUMAN, Q14094 (See protein sequence)
Recommended Name: Cyclin-I  
Size: 377 amino acids; 42557 Da
Developmental stage: Expression is independent of the cell cycle in lung fibroblasts
Secondary accessions: B2R6M0

Explore the universe of human proteins at neXtProt for CCNI: NX_Q14094

Explore proteomics data for CCNI at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18
  • Modification sites at PhosphoSitePlus

  • See CCNI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006826.1  
    ENSEMBL proteins: 
     ENSP00000237654   ENSP00000425935   ENSP00000425360   ENSP00000426467   ENSP00000426235  
     ENSP00000421594   ENSP00000441001  

    CCNI Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CCNI
    OriGene Protein Over-expression Lysate for CCNI
    OriGene MassSpec for CCNI
    OriGene Custom Protein Services for CCNI
    GenScript Custom Purified and Recombinant Proteins Services for CCNI
    Novus Biologicals CCNI Proteins
    Novus Biologicals CCNI Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNI

     
    Search eBioscience for Proteins for CCNI 

     
    antibodies-online proteins for CCNI (2 products) 

     
    antibodies-online peptides for CCNI

    CCNI Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCNI
    Novus Biologicals CCNI Antibodies
    Abcam antibodies for CCNI
    Cloud-Clone Corp. Antibodies for CCNI
    ThermoFisher Antibodies for CCNI
    antibodies-online antibodies for CCNI (24 products) 

    CCNI Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCNI
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCNI
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCNI
    Cloud-Clone Corp. CLIAs for CCNI
    Search eBioscience for ELISAs for CCNI 
    antibodies-online kits for CCNI (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR028856 Cyclin_I

    Graphical View of Domain Structure for InterPro Entry Q14094

    ProtoNet protein and cluster: Q14094

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNI_HUMAN, Q14094
    Similarity: Belongs to the cyclin family


    Find genes that share domains with CCNI           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Phenotypes:
         1 GenomeRNAi human phenotype for CCNI:
     Increased cell death in breast 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccni):
     cellular  homeostasis/metabolism  renal/urinary system 

    Find genes that share phenotypes with CCNI           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCNI

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCNI:
    hsa-mir-423-5p (MIRT038027), hsa-mir-92a-3p (MIRT049008), hsa-mir-148a-3p (MIRT048043), hsa-mir-26b-5p (MIRT028976), hsa-mir-320a (MIRT044457), hsa-mir-374b-5p (MIRT016039)

    Block miRNA regulation of human, mouse, rat CCNI using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CCNI:
    hsa-miR-149 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidCCNI 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCNI
    Predesigned siRNA for gene silencing in human, mouse, rat CCNI

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCNI

    Clone
    Products:
         
    OriGene clones in human, mouse for CCNI (see all 6)
    OriGene ORF clones in mouse, rat for CCNI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCNI (NM_006835)
    Sino Biological Human cDNA Clone for CCNI
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNI

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCNI
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCNI 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNI


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCNI
    Interactions:

        Search GeneGlobe Interaction Network for CCNI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNI (Q140943 ENSP000002376544) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP63Q96MT83, ENSP000003365244I2D: score=2 STRING: ENSP00000336524
    ATRENSP000003437414STRING: ENSP00000343741
    UBCENSP000003448184STRING: ENSP00000344818
    CDC6ENSP000002097284STRING: ENSP00000209728
    PPP6CENSP000003921474STRING: ENSP00000392147
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis NAS9705831

    Find genes that share ontologies with CCNI           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNI



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CCNI gene: 
    NM_006835.2  

    Unigene Cluster for CCNI:

    Cyclin I
    Hs.518827  [show with all ESTs]
    Unigene Representative Sequence: NM_006835
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000237654(uc003hkm.3 uc011ccb.2) ENST00000515468 ENST00000506614
    ENST00000511943 ENST00000505609 ENST00000504697 ENST00000513774 ENST00000507788
    ENST00000515790 ENST00000537948
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCNI using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CCNI:
    hsa-miR-149 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidCCNI 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCNI
    Predesigned siRNA for gene silencing in human, mouse, rat CCNI
    Clone
    Products:
         
    OriGene clones in human, mouse for CCNI (see all 6)
    OriGene ORF clones in mouse, rat for CCNI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCNI (NM_006835)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNI
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCNI
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNI
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNI
      QuantiTect SYBR Green Assays in human, mouse, rat CCNI
      QuantiFast Probe-based Assays in human, mouse, rat CCNI

    Additional mRNA sequence: 

    AB209766.1 AF135162.1 AK222931.1 AK301111.1 AK312632.1 BC000420.2 BC004975.1 BT020019.1 
    CR541783.1 D50310.1 

    Selected DOTS entries (see all 40):

    DT.100683453  DT.87024747  DT.100683449  DT.92341872  DT.96086522  DT.91885583  DT.92324404  DT.95215327 
    DT.95215294  DT.100683446  DT.121254591  DT.91854889  DT.102839656  DT.95215287  DT.100683448  DT.92464873 
    DT.100683445  DT.121254549  DT.92464860  DT.95215296  DT.95282406  DT.100683447  DT.95215308  DT.95215315 

    Selected AceView cDNA sequences (see all 1180):

    BU956287 AI869576 BM128012 AA405203 BM555910 BE382365 CR601669 AA703243 
    CN483826 CB135336 BE326321 AA310922 AJ707455 BC000420 BF591740 BU956183 
    BQ673790 H88954 AI032951 BQ220811 CB135453 AI832925 AA987628 BU078719 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCNI (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c
    SP1:                                -                 -                                                                           
    SP2:                                -     -     -     -                                                                           
    SP3:                                                  -                                                                           
    SP4:                                -     -     -     -     -                                                                     
    SP5:                                -                 -     -     -     -     -                                                   


    ECgene alternative splicing isoforms for CCNI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CCNI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAATCAGG
    CCNI Expression
    About this image


    CCNI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Colon (Gastrointestinal Tract)
    CCNI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNI Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518827

    UniProtKB/Swiss-Prot: CCNI_HUMAN, Q14094
    Tissue specificity: Highest levels in adult heart, brain and skeletal muscle. Lower levels in adult placenta,
    lung, kidney and pancreas. Also high levels in fetal brain and lower levels in fetal lung, liver and kidney. Also
    abundant in testis and thyroid

        Custom PCR Arrays for CCNI
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCNI
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNI
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNI
    QuantiTect SYBR Green Assays in human, mouse, rat CCNI
    QuantiFast Probe-based Assays in human, mouse, rat CCNI
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CCNI gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccni1 , 5 cyclin I1, 5 92.75(n)1
    93.9(a)1
      5 (47.29 cM)5
    124531  NM_017367.31  NP_059063.21 
     931819335 
    chicken
    (Gallus gallus)
    Aves CCNI1 cyclin I 79.49(n)
    81.43(a)
      422634  XM_004941162.1  XP_004941219.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNI6
    cyclin I
    74(a)
    1 ↔ 1
    5(146220355-146241918)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686602 hypothetical protein MGC68660 76.72(n)    BC061670.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.100852 Danio rerio cDNA clone MGC55449 IMAGE2639743, complete more 77(n)    BC044400.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycG6
    Cyclin G
    12(a)
    1 → many
    3R(27422364-27438386)


    ENSEMBL Gene Tree for CCNI (if available)
    TreeFam Gene Tree for CCNI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CCNI gene
    CCNI22  CCNG12  CCNG22  
    3 SIMAP similar genes for CCNI using alignment to 8 protein entries:     CCNI_HUMAN (see all proteins):
    CCNI2    CCNG1    CCNG2

    Find genes that share paralogs with CCNI           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CCNI (see all 766)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs42529541,2
    C,F,H--77968691(-) GGTTTG/CTTGAA 1 -- ds50016Minor allele frequency- C:0.03NS EA WA 710
    rs42529531,2
    C,F,A,H--77968695(-) CTTAGG/ATTTGT 1 -- ds50018Minor allele frequency- A:0.07NS EA WA CSA 706
    rs1827653951,2
    --77968827(+) TTTGCC/TATCTC 1 -- ds50010--------
    rs1874497681,2
    --77968861(+) AGTACC/TCTTTT 1 -- ds50010--------
    rs42529521,2
    C,F,H--77968875(-) TTCCAA/GTTAGT 1 -- ds50015Minor allele frequency- G:0.01NS EA 554
    rs42415981,2
    C,F,A,H--77968968(-) TAATAG/ATTACT 1 -- ds500112Minor allele frequency- A:0.13NS EA NA WA 1072
    rs121861,2
    C,F,H--77969013(+) AATCAG/CGATGC 1 -- ds500111Minor allele frequency- C:0.07NS MN EA NA WA 1028
    rs42529511,2
    C,F,H--77969066(-) GCCCCG/TTCAAA 1 -- ds50015Minor allele frequency- T:0.00NS EA 596
    rs42529501,2
    F--77969071(-) AGCTTG/-CCCCG 1 -- ds50011Minor allele frequency- -:0.01NS 172
    rs2015097491,2
    C--77969161(+) TTGGA-/TTTCT 
            
    TTTTT
    1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCNI (77968311 - 77997158 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCNI:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv879499CNV Loss21882294
    nsv7363OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNI
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with CCNI           About GenesLikeMe

    1 Novoseek inferred disease relationship for CCNI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 6.28 1 15754132 (1)

    Genetic Association Database (GAD): CCNI
    Human Genome Epidemiology (HuGE) Navigator: CCNI (2 documents)

    Export disorders for CCNI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CCNI gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with CCNI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclin I: a new cyclin encoded by a gene isolated from human brain. (PubMed id 7493655)1, 2, 3, 9 Nakamura T.... Mori N. (Exp. Cell Res. 1995)
    2. Expression of a novel isoform of cyclin I in human testis. (PubMed id 9705831)1, 2, 9 Zhu X. and Naz R.K. (Biochem. Biophys. Res. Commun. 1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. (PubMed id 17507299)1, 9 Sun Z.L....Miao Y. (Biochim. Biophys. Acta 2007)
    5. Cyclin I is involved in the regulation of cell cycle progression. (PubMed id 23907122)1 Nagano T....Kamada S. (Cell Cycle 2013)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10983 HGNC: 1595 AceView: CCNI Ensembl:ENSG00000118816 euGenes: HUgn10983
    ECgene: CCNI H-InvDB: CCNI

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CCNI Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccni/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CCNI gene:
    Search GeneIP for patents involving CCNI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCNI  
     OriGene qPCR primer pairs and template standards for CCNI   OriGene Protein Over-expression Lysate for CCNI  
     OriGene MassSpec for CCNI   OriGene clones in human, mouse for CCNI  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCNI   OriGene Purified Protein for CCNI  
     OriGene ORF clones in mouse, rat for CCNI   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCNI   OriGene Custom Protein Services for CCNI  

     
     
     Block miRNA regulation of human, mouse, rat CCNI using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCNI
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNI Predesigned siRNA for gene silencing in human, mouse, rat CCNI
     QuantiFast Probe-based Assays in human, mouse, rat CCNI QuantiTect SYBR Green Assays in human, mouse, rat CCNI
     Custom PCR Arrays for CCNI Search Chromatin IP Primers for CCNI
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNI  Search GeneGlobe Interaction Network for CCNI
     Regulatory tfbs in CCNI promoter
     GenScript Custom Purified and Recombinant Proteins Services for CCNI GenScript cDNA clones with any tag delivered in your preferred vector for CCNI
     GenScript Custom Assay Services for CCNI GenScript Custom overexpressing Cell Line Services for CCNI
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CCNI
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CCNI
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CCNI antibodies
     CCNI proteins
     CCNI lysates
     Antibodies for CCNI
     See all of Abcam's Antibodies, Kits and Proteins for CCNI
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CCNI
     Antibodies for CCNI
     ELISAs for CCNI
     CLIAs for CCNI



     Browse ESI BIO Cell Lines and PureStem Progenitors for CCNI
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNI
     SwitchGear 3'UTR luciferase reporter plasmids for CCNI
     SwitchGear Promoter luciferase reporter plasmids for CCNI
     ThermoFisher Antibodies for CCNI
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNI
     Browse compounds at ApexBio
     Search Addgene for plasmids for CCNI
      Search eBioscience for proteins for CCNI
      Search eBioscience for elisas for CCNI
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CCNI
     antibodies-online antibodies for CCNI (24 products)
     antibodies-online kits for CCNI (16 products)
     antibodies-online peptides for CCNI
     antibodies-online proteins for CCNI (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCNI gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4