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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNI Gene

protein-coding   GIFtS: 50
GCID: GC04M077968

cyclin I

 Explore 8 diseases affiliated with
CCNI via our new
 Human Malady Compendium 
Biological research products
for CCNI
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cyclin I1 2
CYC12
CYI2
Cyclin ITI2
Cyclin-I1

External Ids:    HGNC: 15951   Entrez Gene: 109832   Ensembl: ENSG000001188167   UniProtKB: Q140943   

Export aliases for CCNI gene to outside databases

Previous GC identifers: GC04M077878 GC04M078159 GC04M078361 GC04M078427 GC04M078326 GC04M073720


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNI:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.
Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination
of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found
to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined.
(provided by RefSeq, Jul 2008)

Gene Wiki entry for CCNI


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNI gene promoter:
         COUP-TF1   STAT5B   NCX/Ncx   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   C/EBPalpha   COUP-TF   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CCNI promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

CCNI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNI gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M077968:  view genomic region     (about GC identifiers)

Start:
77,968,311 bp from pter      End:
77,997,158 bp from pter
Size:
28,848 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCNI_HUMAN, Q14094 (See protein sequence)
Recommended Name: Cyclin-I  
Size: 377 amino acids; 42557 Da
Developmental stage: Expression is independent of the cell cycle in lung fibroblasts
Secondary accessions: B2R6M0

Explore the universe of human proteins at neXtProt for CCNI: NX_Q14094

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14094

  • CCNI Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006826.1  
    ENSEMBL proteins: 
     ENSP00000237654   ENSP00000425935   ENSP00000425360   ENSP00000426467   ENSP00000426235  
     ENSP00000421594   ENSP00000441001  

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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CCNI for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N

    Graphical View of Domain Structure for InterPro Entry Q14094

    ProtoNet protein and cluster: Q14094

    1 Blocks protein family: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNI_HUMAN, Q14094
    Similarity: Belongs to the cyclin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    OriGene 3'-UTR Clone: CCNI
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNI
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNI:
    hsa-miR-149 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidCCNI 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNI (see all 7)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNI 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNI

    1 GenomeRNAi human phenotype for CCNI:
     Increased cell death in breast 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccni):
     cellular  homeostasis/metabolism  renal/urinary system 

    CCNI for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCNI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for CCNI (Q140943 ENSP000002376544) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP63Q96MT83, ENSP000003365244I2D: score=2 STRING: ENSP00000336524
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    CDC25AENSP000003037064STRING: ENSP00000303706
    IL1RAPENSP000000725164STRING: ENSP00000072516
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis NAS9705831


    CCNI for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNI
    Search CenterWatch for drugs/clinical trials and news about CCNI 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNI gene: 
    NM_006835.2  

    Unigene Cluster for CCNI:

    Cyclin I
    Hs.518827  [show with all ESTs]
    Unigene Representative Sequence: NM_006835
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000237654(uc003hkm.3 uc011ccb.2) ENST00000515468 ENST00000506614
    ENST00000511943 ENST00000505609 ENST00000504697 ENST00000513774 ENST00000507788
    ENST00000515790 ENST00000537948

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNI
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNI:
    hsa-miR-149 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidCCNI 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNI (see all 7)
    OriGene shRNA RFP: CCNI
    OriGene siRNA: CCNI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNI
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNI
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    GenScript: all cDNA clones in your preferred vector: CCNI (NM_006835)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNI 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNI
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNI

    Additional cDNA sequence: 

    AB209766.1 AF135162.1 AK222931.1 AK301111.1 AK312632.1 BC000420.2 BC004975.1 BT020019.1 
    CR541783.1 D50310.1 

    24/43 DOTS entries (see all 43):

    DT.100683449  DT.100683453  DT.92341872  DT.87024747  DT.96086522  DT.91885583  DT.95215327  DT.92324404 
    DT.100683446  DT.95215294  DT.121254591  DT.91854889  DT.95215287  DT.102839656  DT.92464873  DT.100683448 
    DT.100683445  DT.121254549  DT.121254885  DT.92464860  DT.95215296  DT.95215315  DT.95282406  DT.100683447 

    24/1180 AceView cDNA sequences (see all 1180):

    AI879971 BQ672234 BU728494 CB155399 CN483826 BU784337 BM128012 BF940012 
    AA094874 AI097582 BM669562 BU187633 BF116238 AJ712254 D60574 AI681819 
    CK301014 CD512156 CA441689 AI611682 BU685664 BE393970 BU078719 AI582101 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CCNI (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c
    SP1:                                -                 -                                                                           
    SP2:                                -     -     -     -                                                                           
    SP3:                                                  -                                                                           
    SP4:                                -     -     -     -     -                                                                     
    SP5:                                -                 -     -     -     -     -                                                   


    ECgene alternative splicing isoforms for CCNI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAAATCAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CCNI expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CCNI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNI

    SOURCE GeneReport for Unigene cluster: Hs.518827

    UniProtKB/Swiss-Prot: CCNI_HUMAN, Q14094
    Tissue specificity: Highest levels in adult heart, brain and skeletal muscle. Lower levels in adult placenta, lung,
    kidney and pancreas. Also high levels in fetal brain and lower levels in fetal lung, liver and kidney. Also abundant
    in testis and thyroid

        SABiosciences Custom PCR Arrays for CCNI
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCNI gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CCNI1 cyclin I 79.49(n)
    81.43(a)
      422634  XM_420590.3  XP_420590.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNI6
    --
    72(a)
    1 ↔ 1
    5(146220381-146241918)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686602 hypothetical protein MGC68660 76.72(n)    BC061670.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.100852 Danio rerio cDNA clone MGC55449 IMAGE2639743, complete more 77(n)    BC044400.1 


    ENSEMBL Gene Tree for CCNI (if available)
    TreeFam Gene Tree for CCNI (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNI gene
    CCNI22  CCNG12  CCNG22  
    3 SIMAP similar genes for CCNI using alignment to 8 protein entries:     CCNI_HUMAN (see all proteins):
    CCNI2    CCNG1    CCNG2

    CCNI for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNI
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCNI for disorders           About GeneDecksing

    8 diseases for CCNI:    About MalaCards
    temporal lobe epilepsy    breast cancer    pancreatic carcinoma    pancreatitis
    schizophrenia    thyroiditis    carcinoma    prostatitis

    1 Novoseek disease relationship for CCNI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 6.28 1 15754132 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCNI (2 documents)

    Export disorders for CCNI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNI gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with CCNI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclin I: a new cyclin encoded by a gene isolated from human brain. (PubMed id 7493655)1, 2, 3, 9 Nakamura T.... Mori N. (1995)
    2. Expression of a novel isoform of cyclin I in human testis. (PubMed id 9705831)1, 2, 9 Zhu X. and Naz R.K. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. (PubMed id 17507299)1, 9 Sun Z.L....Miao Y. (2007)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)1 Camargo L.M....Brandon N.J. (2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10983 HGNC: 1595 AceView: CCNI Ensembl:ENSG00000118816 euGenes: HUgn10983
    ECgene: CCNI H-InvDB: CCNI

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNI Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccni/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNI gene:
    Search GeneIP for patents involving CCNI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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