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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNH Gene

protein-coding   GIFtS: 68
GCID: GC05M086690

Cyclin H

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin H1 2     p342 3
MO15-Associated Protein1 2 3     p372 3
CAK Complex Subunit1 2     CAK2 5
CDK-Activating Kinase Complex Subunit1 2     cyclin-H2
Cyclin-Dependent Kinase-Activating Kinase Complex Subunit1 2     

External Ids:    HGNC: 15941   Entrez Gene: 9022   Ensembl: ENSG000001344807   OMIM: 6019535   UniProtKB: P519463   

Export aliases for CCNH gene to outside databases

Previous GC identifers: GC05M085615 GC05M086902 GC05M086728 GC05M086774 GC05M086771 GC05M086725 GC05M081894


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNH Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1.
The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase
(CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein
complexes. They participate in two different transcriptional regulation processes, suggesting an important link
between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on
chromosome 4. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Nov 2010)

GeneCards Summary for CCNH Gene: 
CCNH (cyclin H) is a protein-coding gene. Diseases associated with CCNH include biliary tract cancer, and diffuse large b-cell lymphoma, and among its related super-pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Global Genomic NER (GG-NER). GO annotations related to this gene include protein kinase binding and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946
Function: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK
activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to
the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive
C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of
the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and
activity are constant throughout the cell cycle

Gene Wiki entry for CCNH (Cyclin H) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNH gene promoter:
         HOXA9B   SRF   AML1a   SRF (504 AA)   MEF-2   STAT5A   MEF-2A   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNH promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3-q14   Ensembl cytogenetic band:  5q14.3   HGNC cytogenetic band: 5q13.3-q14

CCNH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNH gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M086690:  view genomic region     (about GC identifiers)

Start:
86,687,311 bp from pter      End:
86,708,850 bp from pter
Size:
21,540 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946 (See protein sequence)
Recommended Name: Cyclin-H  
Size: 323 amino acids; 37643 Da
Subunit: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the
core-TFIIH to form the TFIIH basal transcription factor
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for CCNH:
1JKW (3D)        1KXU (3D)    
Secondary accessions: Q53X72 Q8TBL9

Explore the universe of human proteins at neXtProt for CCNH: NX_P51946

Explore proteomics data for CCNH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51946

  • CCNH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNH Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186118.1  NP_001230.1  

    ENSEMBL proteins: 
     ENSP00000426454   ENSP00000256897   ENSP00000426075  
    Reactome Protein details: P51946
    Human Recombinant Protein Products for CCNH: 
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    Cloud-Clone Corp. Proteins for CCNH 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS7936635
    GO:0005654nucleoplasm TAS--
    GO:0005675holo TFIIH complex IDA9852112
    GO:0016591DNA-directed RNA polymerase II, holoenzyme ----
    GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex IDA8692842

    CCNH for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TFIIH: General transcription factor IIH complex subunits

    5 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR027081 CyclinH/Ccl1
     IPR015429 Cyclin_C/H/T/L
     IPR023598 CyclinC

    Graphical View of Domain Structure for InterPro Entry P51946

    ProtoNet protein and cluster: P51946

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    CCNH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNH_HUMAN, P51946
    Function: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK
    activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to
    the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive
    C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of
    the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and
    activity are constant throughout the cell cycle

         Genatlas biochemistry entry for CCNH:
    cyclin H,37kDa,component of CDK activating kinase (CAK1),forming a ternary complex with CDK7 and MNAT1 (see
    symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle
    control,transcription,DNA repair

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008094contributes to DNA-dependent ATPase activity IDA9852112
    GO:0008353contributes to RNA polymerase II carboxy-terminal domain kinase activity IDA9852112
    GO:0016301kinase activity ----
    GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity IEA--
         
    CCNH for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CCNH:
     Decreased TP53 protein express  Increased cell death in breast  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNH 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNH 
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    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidCCNH 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCNH About   (see all 25)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    RNA Polymerase II Pre-transcription Events0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Transcription of the HIV genome0.70
    mRNA Capping0.93
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    HIV Transcription Elongation0.78
    RNA Polymerase II HIV Promoter Escape0.67
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.70
    Dual incision reaction in GG-NER0.61
    Nucleotide excision repair0.70
    Formation of incision complex in GG-NER0.61
    3Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cyclin D associated events in G10.32
    G1 Phase0.32
    4Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    5Cell cycle
    Cell cycle0.59
    Cell cycle0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CCNH
        Cell cycle Regulation of G1/S transition (part 2)
    Meiosis
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNH
        Breast Cancer Regulation by Stathmin1
    Cyclins and Cell Cycle Regulation
    Salmonella Infection
    Pancreatic Adenocarcinoma

    1 Cell Signaling Technology (CST) Pathway for CCNH
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for CCNH
        Cell cycle Regulation of G1/S transition (part 2)
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4 BioSystems Pathways for CCNH
        Cell cycle
    G1 to S cell cycle control
    Eukaryotic Transcription Initiation
    Retinoic acid receptors-mediated signaling


    5/54        Reactome Pathways for CCNH (see all 54)
        Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase I Promoter Escape
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase I Transcription
    S Phase


    3         Kegg Pathways  (Kegg details for CCNH):
        Basal transcription factors
    Nucleotide excision repair
    Cell cycle


    CCNH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/207 Interacting proteins for CCNH (P519461, 2, 3 ENSP000002568974) via UniProtKB, MINT, STRING, and/or I2D (see all 207)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSSCA1O602322, 3, ENSP000003123184MINT-66160 I2D: score=5 STRING: ENSP00000312318
    CDK2P249411, 3, ENSP000002669704EBI-741406,EBI-375096 I2D: score=3 STRING: ENSP00000266970
    PSMA1P257862, 3MINT-66940 I2D: score=5 
    ENSG00000096150P622693I2D: score=1 
    ENSG00000223367P622693I2D: score=1 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000718nucleotide-excision repair, DNA damage removal TAS--

    CCNH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCNH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNH

    5 Novoseek inferred chemical compound relationships for CCNH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 63.7 8 19228744 (1), 17325859 (1)
    threonine 50.9 8 14597612 (1), 9465303 (1), 11113184 (1), 11676600 (1) (see all 7)
    retinoic acid 41.1 34 12213824 (5), 15345685 (3), 19917671 (3), 16935935 (3) (see all 6)
    serine 7.93 2 18400256 (1), 2208288 (1)
    atp 0 1 14551212 (1)

    Search CenterWatch for drugs/clinical trials and news about CCNH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNH gene (2 alternative transcripts): 
    NM_001199189.1  NM_001239.3  

    Unigene Cluster for CCNH:

    Cyclin H
    Hs.292524  [show with all ESTs]
    Unigene Representative Sequence: AB209342
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505587(uc003kiy.1) ENST00000510921 ENST00000508855(uc003kiz.1)
    ENST00000256897(uc003kjb.3) ENST00000504878(uc003kja.3) ENST00000511207
    ENST00000504115 ENST00000513499 ENST00000510020 ENST00000505230
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB209342.1 AK094534.1 AK291720.1 BC005280.1 BC016705.1 BC016823.1 BC022351.1 BX537673.1 
    CR407658.1 U11791.1 U12685.1 

    21 DOTS entries:

    DT.215123  DT.95172345  DT.95172343  DT.65287245  DT.92454258  DT.92454254  DT.120829249  DT.120829320 
    DT.120829422  DT.100833161  DT.120829262  DT.40275453  DT.205022  DT.92441685  DT.92454256  DT.92454259 
    DT.97820076  DT.120829242  DT.120829324  DT.87016271  DT.95287975 

    24/252 AceView cDNA sequences (see all 252):

    BC005280 BU620481 CD366945 BQ637935 CD677557 AA318747 CN483894 BM698344 
    BM974902 BU658931 BM665487 CB240639 BF511482 BM509272 CA943022 BM672305 
    CD723990 BF000550 CK902745 BM750069 BE896879 BM671301 BQ575834 AA678403 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CCNH (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                                                                    -     -                                                     -                     
    SP2:                                      -                             -     -                                                     -                     
    SP3:                                                                    -     -                                                                           
    SP4:                                      -                             -     -                 -     -                                                   
    SP5:                                                                                                                                -     -     -         


    ECgene alternative splicing isoforms for CCNH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNH expression in normal human tissues (normalized intensities)      CCNH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGAAGA
    CCNH Expression
    About this image


    CCNH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Kidney (Urinary System)
             kidney ; cells in tubules   
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Lower Urinary Tract (Urinary System)
             urinary bladder ; urothelial cells   

    See CCNH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNH

    SOURCE GeneReport for Unigene cluster: Hs.292524
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCNH: 
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNH gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnh1 , 5 cyclin H1, 5 89.89(n)1
    95.05(a)1
      13 (45.05 cM)5
    666711  NM_023243.51  NP_075732.11 
     851894085 
    chicken
    (Gallus gallus)
    Aves CCNH1 cyclin H 75.79(n)
    80.82(a)
      427328  XM_424908.3  XP_424908.2 
    lizard
    (Anolis carolinensis)
    Reptilia CCNH6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    2(20889479-20909410)
    African clawed frog
    (Xenopus laevis)
    Amphibia ccnh-A2 cyclin H 74.9(n)    U20505.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnh1 cyclin H 65.3(n)
    66.77(a)
      541325  NM_001013453.1  NP_001013471.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycH1 , 3 transcription initiation from Pol II
    promoter more3
    Cyclin H1
    47(a)3
    53.82(n)1
    49.09(a)1
      404291  NM_079483.21  NP_524207.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cyh-11 Protein CYH-1 44.52(n)
    35.36(a)
      190078  NM_062163.3  NP_494564.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCL1(YPR025C)4
    CCL11
    Cyclin associated with protein kinase Kin28p, which more4
    Ccl1p1
    44.3(n)1
    30.87(a)1
      16(614558-613377)4
    8561361, 4  NP_015350.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYCH;11 cyclin H;1 47.12(n)
    35.59(a)
      832824  NM_122644.4  NP_198114.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g07376001 hypothetical protein 48.83(n)
    36.12(a)
      4334040  NM_001057738.1  NP_001051203.1 


    ENSEMBL Gene Tree for CCNH (if available)
    TreeFam Gene Tree for CCNH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNH gene

    CCNH for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCNH
    PGOHUM00000245780


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/443 SNPs in CCNH are shown (see all 443)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017600281,2
    C--86689620(-) TTTTTA/TATTTT 2 -- ds50010--------
    rs347275981,2
    C--86689631(+) CAACCACA/-ACAAC 2 -- cds11Minor allele frequency- -:0.50NA 2
    rs709964191,2
    C--86689633(+) ACAACAAC/-TGAAT 2 -- cds11Minor allele frequency- -:0.00NA 2
    rs1501842511,2
    C--86689677(+) TAGCG-/TTAAGA 2 -- ds50010--------
    rs30938611,2
    F--86689678(-) CTCTT-/AACGCT 2 -- ds50011Minor allele frequency- A:0.02NS 178
    rs1423805451,2
    C--86689720(+) TCTGG-/TTTTTT 2 -- ds50010--------
    rs1817705581,2
    --86689741(+) ATTTGA/GAAATG 2 -- ds50010--------
    rs1422613151,2
    --86689823(+) AATACA/CTTCTG 2 -- ds50010--------
    rs1867950931,2
    --86689843(+) AGTAAC/TGGACA 2 -- ds50010--------
    rs30938601,2
    C,F,H--86689858(-) ATATAT/CTTAGC 2 -- ds500190Minor allele frequency- C:0.01NS EA NA PA EU CA WA 5210

    HapMap Linkage Disequilibrium report for CCNH (86687311 - 86708850 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCNH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830379CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601953    OMIM disorders: --

    20/28 diseases for CCNH (see all 28):    About MalaCards
    biliary tract cancer    diffuse large b-cell lymphoma    anaplastic large cell lymphoma    lung adenocarcinoma
    malignant mesothelioma    xeroderma pigmentosum    hemangioma    b-cell lymphomas
    colon adenocarcinoma    osteosarcoma    esophageal cancer    nasopharyngitis
    chronic lymphocytic leukemia    retinoblastoma    adenocarcinoma    multiple sclerosis
    ischemia    ovarian cancer    esophagitis    lung cancer


    CCNH for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for CCNH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 48.8 7 9433129 (1), 19228744 (1), 15126328 (1), 11423981 (1) (see all 6)
    promyelocytic leukemia 35 1 7658699 (1)
    osteosarcoma 10.8 2 8550604 (1)
    cancer lung 0 13 17707548 (4), 19294700 (1)
    glioma 0 1 11856176 (1)
    tumors 0 7 12878869 (1), 19228744 (1), 15126328 (1), 11113200 (1)
    carcinoma 0 2 8416202 (1), 16445666 (1)
    lymphoma 0 1 17325859 (1)
    cancer 0 5 19917671 (5)

    Genetic Association Database (GAD): CCNH
    Human Genome Epidemiology (HuGE) Navigator: CCNH (25 documents)

    Export disorders for CCNH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNH gene, integrated from 9 sources (see all 248):
    (articles sorted by number of sources associating them with CCNH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. (PubMed id 17707548)1, 4, 9 Li Y....Lu D. (2007)
    2. Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively. (PubMed id 9465303)1, 3, 9 Eki T....Hanaoka F. (1998)
    3. The structure of cyclin H: common mode of kinase activation and specific features. (PubMed id 9118957)1, 2, 9 Andersen G.... Moras D. (1997)
    4. Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. (PubMed id 8836101)1, 2, 9 Kim K.K.... Kim S.-H. (1996)
    5. Cdk-activating kinase complex is a component of human transcription factor TFIIH. (PubMed id 7533895)1, 2, 9 Shiekhattar R.... Reinberg D. (1995)
    6. A cyclin associated with the CDK-activating kinase MO15. (PubMed id 8078587)1, 2, 9 Maekelae T.P....Weinberg R.A. (1994)
    7. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PubMed id 8069918)1, 2, 9 Fisher R.P. and Morgan D.O. (1994)
    8. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    9. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (2010)
    10. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 902 HGNC: 1594 AceView: CCNH Ensembl:ENSG00000134480 euGenes: HUgn902
    ECgene: CCNH Kegg: 902 H-InvDB: CCNH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNH Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnh/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNH gene:
    Search GeneIP for patents involving CCNH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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