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Aliases for CCNH Gene

Aliases for CCNH Gene

  • Cyclin H 2 3
  • MO15-Associated Protein 2 3 4
  • Cyclin-Dependent Kinase-Activating Kinase Complex Subunit 2 3
  • CDK-Activating Kinase Complex Subunit 2 3
  • CAK Complex Subunit 2 3
  • P34 3 4
  • CAK 3 6
  • P37 3 4
  • Cyclin-H 3
  • CycH 3

External Ids for CCNH Gene

Previous GeneCards Identifiers for CCNH Gene

  • GC05M085615
  • GC05M086902
  • GC05M086728
  • GC05M086774
  • GC05M086771
  • GC05M086725
  • GC05M086690
  • GC05M081894

Summaries for CCNH Gene

Entrez Gene Summary for CCNH Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]

GeneCards Summary for CCNH Gene

CCNH (Cyclin H) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include protein kinase binding and RNA polymerase II carboxy-terminal domain kinase activity.

UniProtKB/Swiss-Prot for CCNH Gene

  • Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Gene Wiki entry for CCNH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNH Gene

Genomics for CCNH Gene

Regulatory Elements for CCNH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNH Gene

Start:
87,376,254 bp from pter
End:
87,413,033 bp from pter
Size:
36,780 bases
Orientation:
Minus strand

Genomic View for CCNH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNH Gene

Proteins for CCNH Gene

  • Protein details for CCNH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51946-CCNH_HUMAN
    Recommended name:
    Cyclin-H
    Protein Accession:
    P51946
    Secondary Accessions:
    • Q53X72
    • Q8TBL9

    Protein attributes for CCNH Gene

    Size:
    323 amino acids
    Molecular mass:
    37643 Da
    Quaternary structure:
    • Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

    Three dimensional structures from OCA and Proteopedia for CCNH Gene

neXtProt entry for CCNH Gene

Proteomics data for CCNH Gene at MOPED

Post-translational modifications for CCNH Gene

  • Ubiquitination at Lys72
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCNH (CCNH)

No data available for DME Specific Peptides for CCNH Gene

Domains for CCNH Gene

Gene Families for CCNH Gene

HGNC:
  • TFIIH :General transcription factor IIH complex subunits

Protein Domains for CCNH Gene

Suggested Antigen Peptide Sequences for CCNH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51946

UniProtKB/Swiss-Prot:

CCNH_HUMAN :
  • P51946
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.
genes like me logo Genes that share domains with CCNH: view

Function for CCNH Gene

Molecular function for CCNH Gene

GENATLAS Biochemistry: cyclin H,37kDa,component of CDK activating kinase (CAK1),forming a ternary complex with CDK7 and MNAT1 (see symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle control,transcription,DNA repair
UniProtKB/Swiss-Prot Function: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Gene Ontology (GO) - Molecular Function for CCNH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008094 contributes_to DNA-dependent ATPase activity IDA 9852112
GO:0008353 contributes_to RNA polymerase II carboxy-terminal domain kinase activity IDA 9852112
GO:0016301 kinase activity --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
genes like me logo Genes that share ontologies with CCNH: view
genes like me logo Genes that share phenotypes with CCNH: view

Animal Model Products

miRNA for CCNH Gene

miRTarBase miRNAs that target CCNH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCNH Gene

Localization for CCNH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNH Gene COMPARTMENTS Subcellular localization image for CCNH gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CCNH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7936635
GO:0005654 nucleoplasm TAS --
GO:0005675 holo TFIIH complex IDA 9852112
GO:0016591 DNA-directed RNA polymerase II, holoenzyme --
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex IDA 8692842
genes like me logo Genes that share ontologies with CCNH: view

Pathways for CCNH Gene

SuperPathways for CCNH Gene

Superpath Contained pathways
1 Formation of RNA Pol II elongation complex
2 DNA Repair
3 Global Genomic NER (GG-NER)
4 RNA Polymerase I Promoter Opening
5 HIV Life Cycle
genes like me logo Genes that share pathways with CCNH: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCNH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000718 nucleotide-excision repair, DNA damage removal TAS --
genes like me logo Genes that share ontologies with CCNH: view

Compounds for CCNH Gene

(5) Novoseek inferred chemical compound relationships for CCNH Gene

Compound -log(P) Hits PubMed IDs
roscovitine 63.7 2
threonine 50.9 7
retinoic acid 41.1 17
serine 7.93 2
atp 0 1
genes like me logo Genes that share compounds with CCNH: view

Transcripts for CCNH Gene

Unigene Clusters for CCNH Gene

Cyclin H:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNH Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: - - - - - - - - - - - - - - -

Relevant External Links for CCNH Gene

GeneLoc Exon Structure for
CCNH
ECgene alternative splicing isoforms for
CCNH

Expression for CCNH Gene

mRNA expression in normal human tissues for CCNH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNH Gene

SOURCE GeneReport for Unigene cluster for CCNH Gene Hs.292524

genes like me logo Genes that share expressions with CCNH: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCNH Gene

Orthologs for CCNH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNH 35
  • 99.48 (n)
  • 100 (a)
CCNH 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
CCNH 35
  • 91.53 (n)
  • 96.46 (a)
dog
(Canis familiaris)
Mammalia CCNH 35
  • 92.16 (n)
  • 97.21 (a)
CCNH 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnh 35
  • 89.89 (n)
  • 95.05 (a)
Ccnh 16
Ccnh 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNH 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNH 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnh 35
  • 89.68 (n)
  • 94.43 (a)
chicken
(Gallus gallus)
Aves CCNH 35
  • 75.65 (n)
  • 80.56 (a)
CCNH 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNH 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ccnh-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnh 35
  • 69.76 (n)
  • 71.21 (a)
Str.8233 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10544 35
zebrafish
(Danio rerio)
Actinopterygii ccnh 35
  • 65.3 (n)
  • 66.77 (a)
ccnh 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008417 35
  • 53.15 (n)
  • 48.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycH 35
  • 53.94 (n)
  • 49.09 (a)
CycH 36
  • 42 (a)
OneToOne
CycH 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea cyh-1 35
  • 45.96 (n)
  • 37.45 (a)
cyh-1 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCL1 36
  • 23 (a)
OneToOne
CCL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCH;1 35
  • 47.34 (n)
  • 35.93 (a)
rice
(Oryza sativa)
Liliopsida Os03g0737600 35
  • 49.63 (n)
  • 38.06 (a)
Species with no ortholog for CCNH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNH Gene

ENSEMBL:
Gene Tree for CCNH (if available)
TreeFam:
Gene Tree for CCNH (if available)

Paralogs for CCNH Gene

Pseudogenes.org Pseudogenes for CCNH Gene

genes like me logo Genes that share paralogs with CCNH: view

No data available for Paralogs for CCNH Gene

Variants for CCNH Gene

Sequence variations from dbSNP and Humsavar for CCNH Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1807895 -- 87,413,020(-) CTCAG(G/T)GGGCG upstream-variant-2KB, utr-variant-5-prime
rs2230641 - 87,399,457(-) AGAAG(A/C/T)TGCTG missense, reference, nc-transcript-variant
rs2234941 -- 87,412,822(-) TCTGC(G/T)CCCTC utr-variant-5-prime, nc-transcript-variant
rs2234942 - 87,412,712(-) CAACC(G/T)CAAAT utr-variant-5-prime, reference, missense, nc-transcript-variant
rs2234943 -- 87,408,087(-) AGGAG(A/G)GCACT frameshift-variant, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNH Gene

Variant ID Type Subtype PubMed ID
nsv830379 CNV Gain 17160897

Relevant External Links for CCNH Gene

HapMap Linkage Disequilibrium report
CCNH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNH Gene

Disorders for CCNH Gene

(9) Novoseek inferred disease relationships for CCNH Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 48.8 6
promyelocytic leukemia 35 1
osteosarcoma 10.8 1
cancer lung 0 5
glioma 0 1

Relevant External Links for CCNH

Genetic Association Database (GAD)
CCNH
Human Genome Epidemiology (HuGE) Navigator
CCNH
genes like me logo Genes that share disorders with CCNH: view

No data available for UniProtKB/Swiss-Prot for CCNH Gene

Publications for CCNH Gene

  1. Cdk-activating kinase complex is a component of human transcription factor TFIIH. (PMID: 7533895) Shiekhattar R. … Reinberg D. (Nature 1995) 3 4 23
  2. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PMID: 8069918) Fisher R.P. … Morgan D.O. (Cell 1994) 3 4 23
  3. A cyclin associated with the CDK-activating kinase MO15. (PMID: 8078587) Maekelae T.P. … Weinberg R.A. (Nature 1994) 3 4 23
  4. Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. (PMID: 8836101) Kim K.K. … Kim S.-H. (Nat. Struct. Biol. 1996) 3 4 23
  5. The structure of cyclin H: common mode of kinase activation and specific features. (PMID: 9118957) Andersen G. … Moras D. (EMBO J. 1997) 3 4 23

Products for CCNH Gene

Sources for CCNH Gene

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