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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCNH Gene

protein-coding GIFtS: 67
GCID: GC05M086690

cyclin H

Explore 35 diseases affiliated with
CCNH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin H¹ ²		CAK Complex Subunit²
P34¹		CDK-Activating Kinase Complex Subunit²
P37¹		Cyclin-H¹
MO15-Associated Protein² ³		Cyclin-Dependent Kinase-Activating Kinase Complex Subunit²
CAK² ⁵

External Ids:	HGNC: 1594¹	Entrez Gene: 902²	Ensembl: ENSG00000134480⁷	OMIM: 601953⁵	UniProtKB: P51946³

Export aliases for CCNH gene to outside databases

Previous GC identifers: GC05M085615 GC05M086902 GC05M086728 GC05M086774 GC05M086771 GC05M086725 GC05M081894

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNH:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a

dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination

of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex

is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its

kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two

different transcriptional regulation processes, suggesting an important link between basal transcription control and

the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple

transcript variants.(provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946

Function: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the

cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH

basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain

(CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved

in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant

throughout the cell cycle

Gene Wiki entry for CCNH (Cyclin H)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNH gene promoter:
HOXA9B SRF AML1a SRF (504 AA) MEF-2 STAT5A MEF-2A Meis-1a aMEF-2 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNH promoter sequence

Search SABiosciences Chromatin IP Primers for CCNH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3-q14 Ensembl cytogenetic band: 5q14.3 HGNC cytogenetic band: 5q13.3-q14

CCNH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNH gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M086690: view genomic region (about GC identifiers)

Start:	86,687,311 bp from pter	End:	86,708,836 bp from pter
Size:	21,526 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946 (See protein sequence)

Recommended Name: Cyclin-H

Size: 323 amino acids; 37643 Da

Subunit: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH

to form the TFIIH basal transcription factor

Subcellular location: Nucleus

2 PDB 3D structures from and Proteopedia for CCNH:

1JKW (3D)

1KXU (3D)

Secondary accessions: Q53X72 Q8TBL9

Explore the universe of human proteins at neXtProt for CCNH: NX_P51946

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51946

CCNH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001186118.1 NP_001230.1

ENSEMBL proteins:

ENSP00000426454 ENSP00000256897 ENSP00000426075

Reactome Protein details: P51946
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CCNH OriGene Protein Over-expression Lysate: CCNH OriGene Custom Protein Services for CCNH
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	Novus Biologicals CCNH Proteins Novus Biologicals CCNH Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCNH
	Uscn Proteins for CCNH

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	7936635
GO:0005654	nucleoplasm	TAS	--
GO:0005675	holo TFIIH complex	IDA	9852112
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	IDA	8692842

CCNH for ontologies About GeneDecksing

CCNH Antibody Products:

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	Uscn Antibodies for CCNH
	ThermoFisher Antibodies for CCNH

Assay Products for CCNH:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCNH

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCNH for domains About GeneDecksing

5 InterPro domains/families:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR027081 CyclinH/Ccl1

IPR015429 Cyclin_C/H/T/L

IPR023598 CyclinC

Graphical View of Domain Structure for InterPro Entry P51946

ProtoNet protein and cluster: P51946

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946

Similarity: Belongs to the cyclin family. Cyclin C subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946

Function: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the

cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH

basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain

(CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved

in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant

throughout the cell cycle

Genatlas biochemistry entry for CCNH:

cyclin H,37kDa,component of CDK activating kinase (CAK1),forming a ternary complex with CDK7 and MNAT1 (see

symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle

control,transcription,DNA repair

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNH
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		hsa-miR-516a-3p hsa-miR-516b*
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNH

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	contributes to protein kinase activity	IDA	9852112
GO:0005515	protein binding	IPI	--
GO:0008094	contributes to DNA-dependent ATPase activity	IDA	9852112
GO:0008353	contributes to RNA polymerase II carboxy-terminal domain kinase activity	IDA	9852112
GO:0016301	kinase activity	--	--

CCNH for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for CCNH:

Decreased TP53 protein express

Increased cell death in breast

Upregulation of Wnt/beta-caten

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of RNA Pol II elongation complex

8/26 pathways (see all 26)
RNA Polymerase II Transcription Elongation	1.00	Dual incision reaction in TC-NER	0.46
Formation of HIV-1 elongation complex in the absence of HIV-1 Tat	1.00	Formation of transcription-coupled NER (TC-NER) repair complex	0.46
Formation of RNA Pol II elongation complex	1.00	Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition	0.40
Formation of HIV-1 elongation complex containing HIV-1 Tat	0.98	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.40

RNA Polymerase I Chain Elongation

RNA Polymerase I Chain Elongation	1.00	RNA Polymerase I Transcription Termination	0.90
RNA Polymerase I Promoter Escape	0.95	RNA Polymerase I Promoter Clearance	0.86
RNA Polymerase I Transcription Initiation	0.90	RNA Polymerase I Transcription	0.79

Global Genomic NER (GG-NER)

	Global Genomic NER (GG-NER)	1.00			Dual incision reaction in GG-NER	0.61
	Nucleotide excision repair	0.70			Formation of incision complex in GG-NER	0.61

HIV Infection

	HIV Infection	1.00			Transcription Ligand-Dependent Transcription of Retinoid-Target genes	0.28
	Transcription_Ligand-Dependent Transcription of Retinoid-Target genes	0.28

Nucleotide Excision Repair

	Nucleotide Excision Repair	1.00			DNA Repair	0.46
	Transcription-coupled NER (TC-NER)	0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CCNH

	Cell cycle Regulation of G1/S transition (part 2)
	Meiosis
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNH

	Breast Cancer Regulation by Stathmin1
	Cyclins and Cell Cycle Regulation
	Salmonella Infection
	Pancreatic Adenocarcinoma

1 Cell Signaling Technology (CST) Pathway for CCNH

Cell Cycle / Checkpoint Control

2 GeneGo (Thomson Reuters) Pathways for CCNH

	Cell cycle Regulation of G1/S transition (part 2)
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes

4 BioSystems Pathways for CCNH

	G1 to S cell cycle control
	Eukaryotic Transcription Initiation
	Cell cycle
	Retinoic acid receptors-mediated signaling

5/58 Reactome Pathways for CCNH (see all 58)

	Tat-mediated elongation of the HIV-1 transcript
	RNA Polymerase I Promoter Escape
	RNA Polymerase II Transcription Initiation And Promoter Clearance
	RNA Polymerase I Transcription
	S Phase

3 Kegg Pathways (Kegg details for CCNH):

	Basal transcription factors
	Nucleotide excision repair
	Cell cycle

CCNH for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/203 Interacting proteins for CCNH (P51946^{1, 2, 3} ENSP00000256897⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 203)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SSSCA1	O60232²^,³, ENSP00000312318⁴	MINT-66160 I2D: score=5 STRING: ENSP00000312318
PSMA1	P25786²^,³	MINT-66940 I2D: score=5
HIST1H2BC	P62807³	I2D: score=1
HIST1H2BE	P62807³	I2D: score=1
HIST1H2BF	P62807³	I2D: score=1

About this table

Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	IEA	--
GO:0000080	G1 phase of mitotic cell cycle	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--

CCNH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCNH for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCNH
5 Novoseek chemical compound relationships for CCNH gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
roscovitine	63.7	8	19228744 (1), 17325859 (1)
threonine	50.9	8	14597612 (1), 9465303 (1), 11113184 (1), 11676600 (1) (see all 7)
retinoic acid	41.1	34	12213824 (5), 15345685 (3), 19917671 (3), 16935935 (3) (see all 6)
serine	7.93	2	18400256 (1), 2208288 (1)
atp	0	1	14551212 (1)

Search CenterWatch for drugs/clinical trials and news about CCNH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCNH gene (2 alternative transcripts):

NM_001199189.1 NM_001239.3

Unigene Cluster for CCNH:

Cyclin H

Hs.292524 [show with all ESTs]

Unigene Representative Sequence: AB209342

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000505587(uc003kiy.1) ENST00000510921 ENST00000508855(uc003kiz.1)

ENST00000256897(uc003kjb.3) ENST00000504878(uc003kja.3) ENST00000511207

ENST00000504115 ENST00000513499 ENST00000510020 ENST00000505230

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNH
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		hsa-miR-516a-3p hsa-miR-516b*
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Additional cDNA sequence:

AB209342.1 AK094534.1 AK291720.1 BC005280.1 BC016705.1 BC016823.1 BC022351.1 BX537673.1

CR407658.1 U11791.1 U12685.1

17 DOTS entries:

DT.215123 DT.95172345 DT.95172343 DT.65287245 DT.92454258 DT.92454254 DT.120829249 DT.120829320

DT.120829422 DT.120829262 DT.40275453 DT.92441685 DT.92454256 DT.92454259 DT.97820076 DT.205022

DT.95287975

24/252 AceView cDNA sequences (see all 252):

BM665487 BU073290 CB240639 BM671301 BF511482 BM789719 AI761780 CD723990

BM782543 BM710121 CA943022 BF511411 AU098517 CK902745 BM974880 BM672305

BU618767 AA318747 AU102735 BU658931 BM974902 BM750069 BU620481 AI674980

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CCNH (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13
SP1:																							-		-																		-
SP2:													-										-		-																		-
SP3:																							-		-
SP4:													-										-		-						-		-
SP5:																																											-		-		-

ECgene alternative splicing isoforms for CCNH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCNH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAGGAAGA

About this image

CCNH expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCNH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNH

SOURCE GeneReport for Unigene cluster: Hs.292524

SABiosciences Expression via Pathway-Focused PCR Arrays including CCNH:

Cell Cycle in human mouse rat

p53 Signaling Pathway in human mouse rat

DNA Repair in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNH gene from 10/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccnh^{1 , 5}	cyclin H^{1, 5}	89.89(n)¹ 95.05(a)¹		13 (45.05 cM)⁵ 66671¹ NM_023243.5¹ NP_075732.1¹ 85189408⁵
chicken (Gallus gallus)	Aves	CCNH¹	cyclin H	75.79(n) 80.82(a)		427328 XM_424908.3 XP_424908.2
lizard (Anolis carolinensis)	Reptilia	CCNH⁶	--	81(a)	1 ↔ 1	2(20891370-20908504)
African clawed frog (Xenopus laevis)	Amphibia	ccnh-A²	cyclin H	74.9(n)		U20505.1
zebrafish (Danio rerio)	Actinopterygii	ccnh¹	cyclin H	65.3(n) 66.77(a)		541325 NM_001013453.1 NP_001013471.1
fruit fly (Drosophila melanogaster)	Insecta	CycH^{1 , 3}	transcription initiation from Pol II promoter more³ Cyclin H¹	47(a)³ 53.82(n)¹ 49.09(a)¹		40429¹ NM_079483.2¹ NP_524207.1¹
worm (Caenorhabditis elegans)	Secernentea	cyh-1¹	Protein CYH-1	44.52(n) 35.36(a)		190078 NM_062163.3 NP_494564.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CCL1(YPR025C)⁴ CCL1¹	Cyclin associated with protein kinase Kin28p, which more⁴ Ccl1p¹	44.3(n)¹ 30.87(a)¹		16(614558-613377)⁴ 856136^{1, 4} NP_015350.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	CYCH;1¹	cyclin H;1	47.12(n) 35.59(a)		832824 NM_122644.4 NP_198114.2
rice (Oryza sativa)	Liliopsida	Os03g0737600¹	hypothetical protein	48.83(n) 36.12(a)		4334040 NM_001057738.1 NP_001051203.1

ENSEMBL Gene Tree for CCNH (if available)
TreeFam Gene Tree for CCNH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCNH gene

CCNH for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CCNH
PGOHUM00000245780

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201760028^1,2	C	--	86689620(-)	`TTTTTA/TATTTT`	2	--	ds500¹		0	--	--	--	--
rs34727598^1,2	C	--	86689631(+)	`CAACCACA/-ACAAC`	2	--	ds500¹		1		NA	2
rs150184251^1,2	C,	--	86689677(+)	`TAGCG-/TTAAGA`	2	--	ds500¹		0	--	--	--	--
rs3093861^1,2	F	--	86689678(-)	`CTCTT-/AACGCT`	2	--	ds500¹		1		NS	178
rs142380545^1,2	C,	--	86689720(+)	`TCTGG-/TTTTTT`	2	--	ds500¹		0	--	--	--	--
rs181770558^1,2		--	86689741(+)	`ATTTGA/GAAATG`	2	--	ds500¹		0	--	--	--	--
rs142261315^1,2		--	86689823(+)	`AATACA/CTTCTG`	2	--	ds500¹		0	--	--	--	--
rs186795093^1,2		--	86689843(+)	`AGTAAC/TGGACA`	2	--	ds500¹		0	--	--	--	--
rs3093860^1,2	C,F,H,	--	86689858(-)	`ATATAT/CTTAGC`	2	--	ds500¹		90		NS EA NA PA EU CA WA	5210
rs191966787^1,2		--	86689921(+)	`TTCCTG/TAACAC`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCNH (86687311 - 86708836 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNH: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNH

DNA2.0 Custom Variant and Variant Library Synthesis for CCNH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCNH for disorders           About GeneDecksing

OMIM gene information: 601953    OMIM disorders: --

20/35 diseases for CCNH (see all 35):    About MalaCards

diffuse large b-cell lymphoma photosensitive trichthiodystrophy b-cell lymphomas anaplastic large cell lymphoma

xeroderma pigmentosum biliary tract cancer chronic lymphocytic leukemia malignant mesothelioma

epithelial ovarian cancer lymphocytic leukemia multiple sclerosis ovarian cancer

hemangioma colon adenocarcinoma osteosarcoma lung cancer

lung adenocarcinoma pulmonary disease colon carcinoma adenocarcinoma

9 Novoseek disease relationships for CCNH gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	48.8	7	9433129 (1), 19228744 (1), 15126328 (1), 11423981 (1) (see all 6)
promyelocytic leukemia	35	1	7658699 (1)
osteosarcoma	10.8	2	8550604 (1)
cancer lung	0	13	17707548 (4), 19294700 (1)
glioma	0	1	11856176 (1)
tumors	0	7	12878869 (1), 19228744 (1), 15126328 (1), 11113200 (1)
carcinoma	0	2	8416202 (1), 16445666 (1)
lymphoma	0	1	17325859 (1)
cancer	0	5	19917671 (5)

Genetic Association Database (GAD): CCNH
Human Genome Epidemiology (HuGE) Navigator: CCNH (25 documents)

Export disorders for CCNH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCNH gene, integrated from 9 sources (see all 240):
(articles sorted by number of sources associating them with CCNH)

Utopia: connect your pdf to the dynamic
world of online information

Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively. (PubMed id 9465303)^{1, 3, 9} Eki T....Hanaoka F. (1998)
The structure of cyclin H: common mode of kinase activation and specific features. (PubMed id 9118957)^{1, 2, 9} Andersen G.... Moras D. (1997)
Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. (PubMed id 8836101)^{1, 2, 9} Kim K.K.... Kim S.-H. (1996)
Cdk-activating kinase complex is a component of human transcription factor TFIIH. (PubMed id 7533895)^{1, 2, 9} Shiekhattar R.... Reinberg D. (1995)
A cyclin associated with the CDK-activating kinase MO15. (PubMed id 8078587)^{1, 2, 9} Maekelae T.P....Weinberg R.A. (1994)
A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PubMed id 8069918)^{1, 2, 9} Fisher R.P. and Morgan D.O. (1994)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
TFIIH is negatively regulated by cdk8-containing mediator complexes. (PubMed id 10993082)^{1, 2} Akoulitchev S.... Reinberg D. (2000)
Identification of single nucleotide polymorphisms in human DNA repair genes. (PubMed id 11062157)^{1, 4} Ford B.N....Glickman B.W. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 902	HGNC: 1594	AceView: CCNH	Ensembl:ENSG00000134480	euGenes: HUgn902
ECgene: CCNH	Kegg: 902	H-InvDB: CCNH

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCNH	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCNH	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccnh/

Intellectual Property for CCNH gene
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Patent Information for CCNH gene:
Search GeneIP for patents involving CCNH

GeneCards and IP:
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