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CCNH Gene

protein-coding   GIFtS: 69
GCID: GC05M086690

Cyclin H

  Search for CCNH
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin H1 2     p342 3
MO15-Associated Protein1 2 3     p372 3
CAK Complex Subunit1 2     CAK2 5
CDK-Activating Kinase Complex Subunit1 2     CycH2
Cyclin-Dependent Kinase-Activating Kinase Complex Subunit1 2     cyclin-H2

External Ids:    HGNC: 15941   Entrez Gene: 9022   Ensembl: ENSG000001344807   OMIM: 6019535   UniProtKB: P519463   

Export aliases for CCNH gene to outside databases

Previous GC identifers: GC05M085615 GC05M086902 GC05M086728 GC05M086774 GC05M086771 GC05M086725 GC05M081894


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNH Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1.
The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase
(CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein
complexes. They participate in two different transcriptional regulation processes, suggesting an important link
between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on
chromosome 4. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Nov 2010)

GeneCards Summary for CCNH Gene:
CCNH (cyclin H) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II carboxy-terminal domain kinase activity and protein kinase binding.

UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946
Function: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK
activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to
the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive
C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of
the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and
activity are constant throughout the cell cycle

Gene Wiki entry for CCNH (Cyclin H) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNH gene promoter:
         HOXA9B   SRF   AML1a   SRF (504 AA)   MEF-2   STAT5A   MEF-2A   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNH promoter sequence
   Search Chromatin IP Primers for CCNH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3-q14   Ensembl cytogenetic band:  5q14.3   HGNC cytogenetic band: 5q13.3-q14

CCNH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNH gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M086690:  view genomic region     (about GC identifiers)

Start:
86,687,311 bp from pter      End:
86,708,850 bp from pter
Size:
21,540 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946 (See protein sequence)
Recommended Name: Cyclin-H  
Size: 323 amino acids; 37643 Da
Subunit: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the
core-TFIIH to form the TFIIH basal transcription factor
2 PDB 3D structures from and Proteopedia for CCNH:
1JKW (3D)        1KXU (3D)    
Secondary accessions: Q53X72 Q8TBL9

Explore the universe of human proteins at neXtProt for CCNH: NX_P51946

Explore proteomics data for CCNH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys72
  • Modification sites at PhosphoSitePlus

  • See CCNH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186118.1  NP_001230.1  

    ENSEMBL proteins: 
     ENSP00000426454   ENSP00000256897   ENSP00000426075  
    Reactome Protein details: P51946

    CCNH Human Recombinant Protein Products:

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    Novus Biologicals CCNH Proteins
    Novus Biologicals CCNH Lysates
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    Cloud-Clone Corp. Proteins for CCNH

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TFIIH: General transcription factor IIH complex subunits

    5 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR027081 CyclinH/Ccl1
     IPR015429 Cyclin_C/H/T/L
     IPR023598 CyclinC

    Graphical View of Domain Structure for InterPro Entry P51946

    ProtoNet protein and cluster: P51946

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNH_HUMAN, P51946
    Similarity: Belongs to the cyclin family. Cyclin C subfamily


    Find genes that share domains with CCNH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNH_HUMAN, P51946
    Function: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK
    activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to
    the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive
    C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of
    the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and
    activity are constant throughout the cell cycle

         Genatlas biochemistry entry for CCNH:
    cyclin H,37kDa,component of CDK activating kinase (CAK1),forming a ternary complex with CDK7 and MNAT1 (see
    symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle
    control,transcription,DNA repair

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008094contributes to DNA-dependent ATPase activity IDA9852112
    GO:0008353contributes to RNA polymerase II carboxy-terminal domain kinase activity IDA9852112
    GO:0016301kinase activity ----
    GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity IEA--
         
    Find genes that share ontologies with CCNH           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CCNH:
     Decreased TP53 protein express  Increased cell death in breast  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNH
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNH

    miRNA
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    miRTarBase miRNAs that target CCNH:
    hsa-mir-1301-3p (MIRT035962)

    Block miRNA regulation of human, mouse, rat CCNH using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CCNH:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidCCNH 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCNH
    Predesigned siRNA for gene silencing in human, mouse, rat CCNH

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCNH (NM_001239)
    Sino Biological Human cDNA Clone for CCNH
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNH

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNH_HUMAN, P51946: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005675holo TFIIH complex IDA9852112
    GO:0005730NOT nucleolus IDA--
    GO:0016591DNA-directed RNA polymerase II, holoenzyme ----

    Find genes that share ontologies with CCNH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNH About   (see all 23)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    mRNA Capping0.93
    RNA Polymerase II Pre-transcription Events0.73
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Transcription of the HIV genome0.71
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    Formation of the Early Elongation Complex0.77
    RNA Polymerase II Transcription Initiation0.67
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.69
    Dual incision reaction in GG-NER0.62
    Nucleotide excision repair0.69
    Formation of incision complex in GG-NER0.62
    3Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cyclin D associated events in G10.31
    G1 Phase0.31
    4E2F mediated regulation of DNA replication
    G1/S Transition0.81
    G1 to S cell cycle control0.35
    Mitotic G1-G1/S phases0.81
    5Cell cycle
    Cell cycle0.59
    Cell cycle0.59


    Find genes that share SuperPaths with CCNH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNH
        Breast Cancer Regulation by Stathmin1
    Cyclins and Cell Cycle Regulation
    Salmonella Infection
    Pancreatic Adenocarcinoma

    1 Cell Signaling Technology (CST) Pathway for CCNH
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for CCNH
        Cell cycle Regulation of G1/S transition (part 2)
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4 BioSystems Pathways for CCNH
        Cell cycle
    G1 to S cell cycle control
    Eukaryotic Transcription Initiation
    Retinoic acid receptors-mediated signaling


    Selected Reactome Pathways for CCNH (see all 31)
        Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase I Promoter Escape
    NoRC negatively regulates rRNA expression
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    3 Kegg Pathways  (Kegg details for CCNH):
        Basal transcription factors
    Nucleotide excision repair
    Cell cycle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNH: 
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNH (P519461, 2, 3 ENSP000002568974) via UniProtKB, MINT, STRING, and/or I2D (see all 276)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSSCA1O602322, 3, ENSP000003123184MINT-66160 I2D: score=5 STRING: ENSP00000312318
    PSMA1P257862, 3MINT-66940 I2D: score=5 
    ENSG00000096150P622693I2D: score=1 
    ENSG00000223367P622693I2D: score=1 
    ENSG00000226225P622693I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000718nucleotide-excision repair, DNA damage removal TAS--

    Find genes that share ontologies with CCNH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNH

    5 Novoseek inferred chemical compound relationships for CCNH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 63.7 8 19228744 (1), 17325859 (1)
    threonine 50.9 8 14597612 (1), 9465303 (1), 11113184 (1), 11676600 (1) (see all 7)
    retinoic acid 41.1 34 12213824 (5), 15345685 (3), 19917671 (3), 16935935 (3) (see all 6)
    serine 7.93 2 18400256 (1), 2208288 (1)
    atp 0 1 14551212 (1)



    Find genes that share compounds with CCNH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNH gene (2 alternative transcripts): 
    NM_001199189.1  NM_001239.3  

    Unigene Cluster for CCNH:

    Cyclin H
    Hs.292524  [show with all ESTs]
    Unigene Representative Sequence: AB209342
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505587(uc003kiy.1) ENST00000510921 ENST00000508855(uc003kiz.1)
    ENST00000256897(uc003kjb.3) ENST00000504878(uc003kja.3) ENST00000511207
    ENST00000504115 ENST00000513499 ENST00000510020 ENST00000505230
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CCNH:
    hsa-miR-516a-3p hsa-miR-516b*
    SwitchGear 3'UTR luciferase reporter plasmidCCNH 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCNH (NM_001239)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNH
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCNH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNH
      QuantiTect SYBR Green Assays in human, mouse, rat CCNH
      QuantiFast Probe-based Assays in human, mouse, rat CCNH

    Additional mRNA sequence: 

    AB209342.1 AK094534.1 AK291720.1 BC005280.1 BC016705.1 BC016823.1 BC022351.1 BX537673.1 
    CR407658.1 U11791.1 U12685.1 

    21 DOTS entries:

    DT.215123  DT.95172345  DT.95172343  DT.65287245  DT.92454258  DT.92454254  DT.120829249  DT.120829320 
    DT.120829422  DT.100833161  DT.120829262  DT.40275453  DT.205022  DT.92441685  DT.92454256  DT.92454259 
    DT.97820076  DT.120829242  DT.120829324  DT.87016271  DT.95287975 

    Selected AceView cDNA sequences (see all 252):

    BF000550 BU620481 BQ637935 CA943022 CB241823 AA678403 BU167387 CD677557 
    BM974902 U12685 BM698344 BQ575834 AU102735 BU618767 AU098517 CB240639 
    BM665487 CB529822 CD366945 BM782543 AI674980 BX537673 BM710121 AK094534 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCNH (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                                                                    -     -                                                     -                     
    SP2:                                      -                             -     -                                                     -                     
    SP3:                                                                    -     -                                                                           
    SP4:                                      -                             -     -                 -     -                                                   
    SP5:                                                                                                                                -     -     -         


    ECgene alternative splicing isoforms for CCNH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCNH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGAAGA
    CCNH Expression
    About this image


    CCNH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Brain (Nervous System)
             Cerebellum
    CCNH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292524
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNH: 
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCNH
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNH
    QuantiTect SYBR Green Assays in human, mouse, rat CCNH
    QuantiFast Probe-based Assays in human, mouse, rat CCNH
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNH gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnh1 , 5 cyclin H1, 5 89.89(n)1
    95.05(a)1
      13 (45.05 cM)5
    666711  NM_023243.51  NP_075732.11 
     851894085 
    chicken
    (Gallus gallus)
    Aves CCNH1 cyclin H 75.65(n)
    80.56(a)
      427328  XM_424908.4  XP_424908.2 
    lizard
    (Anolis carolinensis)
    Reptilia CCNH6
    cyclin H
    81(a)
    1 ↔ 1
    2(20889479-20909410)
    African clawed frog
    (Xenopus laevis)
    Amphibia ccnh-A2 cyclin H 74.9(n)    U20505.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnh1 cyclin H 65.3(n)
    66.77(a)
      541325  NM_001013453.1  NP_001013471.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycH1 , 3 transcription initiation from Pol II
    promoter more3
    Cyclin H1
    47(a)3
    53.94(n)1
    49.09(a)1
      404291  NM_079483.31  NP_524207.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cyh-11 cyh-1 45.96(n)
    37.45(a)
      190078  NM_062163.4  NP_494564.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CCL1(YPR025C)4 Cyclin associated with protein kinase Kin28p, which more   --   16(614558-613377) 856136  NP_015350.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYCH;11 CYCH;1 47.34(n)
    35.93(a)
      832824  NM_122644.4  NP_198114.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g07376001 Os03g0737600 49.63(n)
    38.06(a)
      4334040  NM_001057738.1  NP_001051203.1 


    ENSEMBL Gene Tree for CCNH (if available)
    TreeFam Gene Tree for CCNH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNH gene

    Find genes that share paralogs with CCNH           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCNH
    PGOHUM00000245780


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNH (see all 443)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017600281,2
    C--86689620(-) TTTTTA/TATTTT 2 -- ds50010--------
    rs347275981,2
    C--86689631(+) CAACCACA/-ACAAC 2 -- cds11Minor allele frequency- -:0.50NA 2
    rs709964191,2
    C--86689633(+) ACAACAAC/-TGAAT 2 -- cds11Minor allele frequency- -:0.00NA 2
    rs1501842511,2
    C--86689677(+) TAGCG-/TTAAGA 2 -- ds50010--------
    rs30938611,2
    F--86689678(-) CTCTT-/AACGCT 2 -- ds50011Minor allele frequency- A:0.02NS 178
    rs1423805451,2
    C--86689720(+) TCTGG-/TTTTTT 2 -- ds50010--------
    rs1817705581,2
    --86689741(+) ATTTGA/GAAATG 2 -- ds50010--------
    rs1422613151,2
    --86689823(+) AATACA/CTTCTG 2 -- ds50010--------
    rs1867950931,2
    --86689843(+) AGTAAC/TGGACA 2 -- ds50010--------
    rs30938601,2
    C,F,H--86689858(-) ATATAT/CTTAGC 2 -- ds500190Minor allele frequency- C:0.01NS EA NA PA EU CA WA 5210

    HapMap Linkage Disequilibrium report for CCNH (86687311 - 86708850 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCNH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830379CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNH
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601953    OMIM disorders: --


    Find genes that share disorders with CCNH           About GenesLikeMe

    9 Novoseek inferred disease relationships for CCNH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 48.8 7 9433129 (1), 19228744 (1), 15126328 (1), 11423981 (1) (see all 6)
    promyelocytic leukemia 35 1 7658699 (1)
    osteosarcoma 10.8 2 8550604 (1)
    cancer lung 0 13 17707548 (4), 19294700 (1)
    glioma 0 1 11856176 (1)
    tumors 0 7 12878869 (1), 19228744 (1), 15126328 (1), 11113200 (1)
    carcinoma 0 2 8416202 (1), 16445666 (1)
    lymphoma 0 1 17325859 (1)
    cancer 0 5 19917671 (5)

    Genetic Association Database (GAD): CCNH
    Human Genome Epidemiology (HuGE) Navigator: CCNH (25 documents)

    Export disorders for CCNH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNH gene, integrated from 10 sources (see all 249):
    (articles sorted by number of sources associating them with CCNH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. (PubMed id 17707548)1, 4, 9 Li Y....Lu D. (Lung Cancer 2007)
    2. Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively. (PubMed id 9465303)1, 3, 9 Eki T....Hanaoka F. (Genomics 1998)
    3. The structure of cyclin H: common mode of kinase activation and specific features. (PubMed id 9118957)1, 2, 9 Andersen G.... Moras D. (EMBO J. 1997)
    4. Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. (PubMed id 8836101)1, 2, 9 Kim K.K.... Kim S.-H. (Nat. Struct. Biol. 1996)
    5. Cdk-activating kinase complex is a component of human transcription factor TFIIH. (PubMed id 7533895)1, 2, 9 Shiekhattar R.... Reinberg D. (Nature 1995)
    6. A cyclin associated with the CDK-activating kinase MO15. (PubMed id 8078587)1, 2, 9 Maekelae T.P....Weinberg R.A. (Nature 1994)
    7. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. (PubMed id 8069918)1, 2, 9 Fisher R.P. and Morgan D.O. (Cell 1994)
    8. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    9. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
    10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 902 HGNC: 1594 AceView: CCNH Ensembl:ENSG00000134480 euGenes: HUgn902
    ECgene: CCNH Kegg: 902 H-InvDB: CCNH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNH Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnh/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNH gene:
    Search GeneIP for patents involving CCNH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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