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Aliases for CCNH Gene

Aliases for CCNH Gene

  • Cyclin H 2 3 5
  • MO15-Associated Protein 2 3 4
  • Cyclin-Dependent Kinase-Activating Kinase Complex Subunit 2 3
  • CDK-Activating Kinase Complex Subunit 2 3
  • CAK Complex Subunit 2 3
  • P34 3 4
  • P37 3 4
  • CycH 3
  • CAK 3

External Ids for CCNH Gene

Previous GeneCards Identifiers for CCNH Gene

  • GC05M085615
  • GC05M086902
  • GC05M086728
  • GC05M086774
  • GC05M086771
  • GC05M086725
  • GC05M086690
  • GC05M081894

Summaries for CCNH Gene

Entrez Gene Summary for CCNH Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]

GeneCards Summary for CCNH Gene

CCNH (Cyclin H) is a Protein Coding gene. Diseases associated with CCNH include breast cancer and fructose intolerance. Among its related pathways are Gene Expression and HIV Life Cycle. GO annotations related to this gene include protein kinase binding and DNA-dependent ATPase activity.

UniProtKB/Swiss-Prot for CCNH Gene

  • Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Gene Wiki entry for CCNH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNH Gene

Genomics for CCNH Gene

Regulatory Elements for CCNH Gene

Promoters for CCNH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNH on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNH Gene

Chromosome:
5
Start:
87,391,493 bp from pter
End:
87,413,033 bp from pter
Size:
21,541 bases
Orientation:
Minus strand

Genomic View for CCNH Gene

Genes around CCNH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNH Gene

Proteins for CCNH Gene

  • Protein details for CCNH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51946-CCNH_HUMAN
    Recommended name:
    Cyclin-H
    Protein Accession:
    P51946
    Secondary Accessions:
    • Q53X72
    • Q8TBL9

    Protein attributes for CCNH Gene

    Size:
    323 amino acids
    Molecular mass:
    37643 Da
    Quaternary structure:
    • Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

    Three dimensional structures from OCA and Proteopedia for CCNH Gene

neXtProt entry for CCNH Gene

Proteomics data for CCNH Gene at MOPED

Post-translational modifications for CCNH Gene

  • Ubiquitination at Lys 72
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNH Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCNH (CCNH)

No data available for DME Specific Peptides for CCNH Gene

Domains & Families for CCNH Gene

Gene Families for CCNH Gene

Protein Domains for CCNH Gene

Suggested Antigen Peptide Sequences for CCNH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51946

UniProtKB/Swiss-Prot:

CCNH_HUMAN :
  • Belongs to the cyclin family. Cyclin C subfamily.
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.
genes like me logo Genes that share domains with CCNH: view

Function for CCNH Gene

Molecular function for CCNH Gene

GENATLAS Biochemistry:
cyclin H,37kDa,component of CDK activating kinase (CAK1),forming a ternary complex with CDK7 and MNAT1 (see symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle control,transcription,DNA repair
UniProtKB/Swiss-Prot Function:
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
genes like me logo Genes that share phenotypes with CCNH: view

Animal Model Products

miRNA for CCNH Gene

miRTarBase miRNAs that target CCNH

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNH Gene

Localization for CCNH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNH Gene COMPARTMENTS Subcellular localization image for CCNH gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CCNH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CCNH: view

Pathways & Interactions for CCNH Gene

SuperPathways for CCNH Gene

Superpath Contained pathways
1 RNA Polymerase II Transcription Initiation And Promoter Clearance
2 Formation of the HIV-1 Early Elongation Complex
3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
4 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
5 Infectious disease
.48
genes like me logo Genes that share pathways with CCNH: view

SIGNOR curated interactions for CCNH Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006294 nucleotide-excision repair, preincision complex assembly TAS --
genes like me logo Genes that share ontologies with CCNH: view

Drugs & Compounds for CCNH Gene

(4) Drugs for CCNH Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCNH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNH: view

Transcripts for CCNH Gene

Unigene Clusters for CCNH Gene

Cyclin H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNH Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: - - - - - - - - - - - - - - -

Relevant External Links for CCNH Gene

GeneLoc Exon Structure for
CCNH
ECgene alternative splicing isoforms for
CCNH

Expression for CCNH Gene

mRNA expression in normal human tissues for CCNH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNH Gene

This gene is overexpressed in Liver (42.2) and Breast (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNH Gene



SOURCE GeneReport for Unigene cluster for CCNH Gene Hs.292524

genes like me logo Genes that share expression patterns with CCNH: view

Protein tissue co-expression partners for CCNH Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCNH Gene

Orthologs for CCNH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNH 35
  • 91.53 (n)
  • 96.46 (a)
-- 36
  • 89 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCNH 35
  • 92.16 (n)
  • 97.21 (a)
CCNH 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnh 35
  • 89.89 (n)
  • 95.05 (a)
Ccnh 16
Ccnh 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNH 35
  • 99.48 (n)
  • 100 (a)
CCNH 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnh 35
  • 89.68 (n)
  • 94.43 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNH 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNH 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNH 35
  • 75.65 (n)
  • 80.56 (a)
CCNH 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNH 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnh 35
  • 69.76 (n)
  • 71.21 (a)
Str.8233 35
African clawed frog
(Xenopus laevis)
Amphibia ccnh-A 35
zebrafish
(Danio rerio)
Actinopterygii ccnh 35
  • 65.3 (n)
  • 66.77 (a)
ccnh 36
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10544 35
fruit fly
(Drosophila melanogaster)
Insecta CycH 37
  • 47 (a)
CycH 35
  • 53.94 (n)
  • 49.09 (a)
CycH 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008417 35
  • 53.15 (n)
  • 48.65 (a)
worm
(Caenorhabditis elegans)
Secernentea cyh-1 35
  • 45.96 (n)
  • 37.45 (a)
cyh-1 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCL1 36
  • 23 (a)
OneToOne
CCL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCH;1 35
  • 47.34 (n)
  • 35.93 (a)
rice
(Oryza sativa)
Liliopsida Os03g0737600 35
  • 49.63 (n)
  • 38.06 (a)
Species with no ortholog for CCNH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNH Gene

ENSEMBL:
Gene Tree for CCNH (if available)
TreeFam:
Gene Tree for CCNH (if available)

Paralogs for CCNH Gene

Pseudogenes.org Pseudogenes for CCNH Gene

genes like me logo Genes that share paralogs with CCNH: view

No data available for Paralogs for CCNH Gene

Variants for CCNH Gene

Sequence variations from dbSNP and Humsavar for CCNH Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_013067 -
VAR_013068 -
rs2266691 - 87,408,088(-) GGAGA(A/G)GGCAC reference, missense
rs2230641 - 87,399,457(-) AGAAG(A/C/T)TGCTG reference, missense
rs3804229 -- 87,398,589(+) ATTTT(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNH Gene

Variant ID Type Subtype PubMed ID
nsv830379 CNV Gain 17160897

Variation tolerance for CCNH Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNH Gene

HapMap Linkage Disequilibrium report
CCNH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNH Gene

Disorders for CCNH Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCNH Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
fructose intolerance
  • hereditary fructose intolerance syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CCNH in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNH

Genetic Association Database (GAD)
CCNH
Human Genome Epidemiology (HuGE) Navigator
CCNH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNH
genes like me logo Genes that share disorders with CCNH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNH Gene

Publications for CCNH Gene

  1. Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. (PMID: 17707548) Li Y. … Lu D. (Lung Cancer 2007) 3 23 48 67
  2. Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively. (PMID: 9465303) Eki T. … Hanaoka F. (Genomics 1998) 2 3 23
  3. Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma. (PMID: 18400256) Bavi P. … Al-Kuraya K.S. (Hum. Pathol. 2008) 3 23
  4. [Expression and clinical significance of cyclin H and CDK7 in human hemangiomas]. (PMID: 18950027) Liu J. … Shan S.G. (Zhonghua Zheng Xing Wai Ke Za Zhi 2008) 3 23
  5. Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells. (PMID: 17628022) Luo P. … Wu L. (Stem Cells 2007) 3 23

Products for CCNH Gene

Sources for CCNH Gene

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