External Ids for CCNG2 Gene
Previous GeneCards Identifiers for CCNG2 Gene
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNG2 Gene
CCNG2 (Cyclin G2) is a Protein Coding gene. Diseases associated with CCNG2 include Esophageal Cancer. Among its related pathways are Mitotic G1-G1/S phases and p53 signaling pathway. An important paralog of this gene is CCNI.
UniProtKB/Swiss-Prot for CCNG2 Gene
May play a role in growth regulation and in negative regulation of cell cycle progession.