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Aliases for CCNG2 Gene

Aliases for CCNG2 Gene

  • Cyclin G2 2 3 5

External Ids for CCNG2 Gene

Previous GeneCards Identifiers for CCNG2 Gene

  • GC04P077988
  • GC04P078268
  • GC04P078471
  • GC04P078536
  • GC04P078435
  • GC04P078078
  • GC04P073832

Summaries for CCNG2 Gene

Entrez Gene Summary for CCNG2 Gene

  • The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNG2 Gene

CCNG2 (Cyclin G2) is a Protein Coding gene. Diseases associated with CCNG2 include esophageal cancer. Among its related pathways are Wnt Signaling Pathway (WikiPathways) and p53 signaling pathway. An important paralog of this gene is CCNI.

UniProtKB/Swiss-Prot for CCNG2 Gene

  • May play a role in growth regulation and in negative regulation of cell cycle progession.

Gene Wiki entry for CCNG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNG2 Gene

Genomics for CCNG2 Gene

Regulatory Elements for CCNG2 Gene

Promoters for CCNG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNG2 Gene

Chromosome:
4
Start:
77,157,151 bp from pter
End:
77,433,388 bp from pter
Size:
276,238 bases
Orientation:
Plus strand

Genomic View for CCNG2 Gene

Genes around CCNG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNG2 Gene

Proteins for CCNG2 Gene

  • Protein details for CCNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16589-CCNG2_HUMAN
    Recommended name:
    Cyclin-G2
    Protein Accession:
    Q16589
    Secondary Accessions:
    • B4DF25
    • Q6FGA7
    • Q6FGC6

    Protein attributes for CCNG2 Gene

    Size:
    344 amino acids
    Molecular mass:
    38866 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNG2 Gene

Proteomics data for CCNG2 Gene at MOPED

Post-translational modifications for CCNG2 Gene

  • Ubiquitination at Lys 36
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNG2 Gene

Antibody Products

No data available for DME Specific Peptides for CCNG2 Gene

Domains & Families for CCNG2 Gene

Gene Families for CCNG2 Gene

Protein Domains for CCNG2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q16589

UniProtKB/Swiss-Prot:

CCNG2_HUMAN :
  • Belongs to the cyclin family. Cyclin G subfamily.
Family:
  • Belongs to the cyclin family. Cyclin G subfamily.
genes like me logo Genes that share domains with CCNG2: view

Function for CCNG2 Gene

Molecular function for CCNG2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in growth regulation and in negative regulation of cell cycle progession.
UniProtKB/Swiss-Prot Induction:
Activated by actinomycin-D induced DNA damage.

Phenotypes for CCNG2 Gene

genes like me logo Genes that share phenotypes with CCNG2: view

Animal Model Products

miRNA for CCNG2 Gene

miRTarBase miRNAs that target CCNG2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNG2 Gene

Localization for CCNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNG2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNG2 Gene COMPARTMENTS Subcellular localization image for CCNG2 gene
Compartment Confidence
cytosol 3
nucleus 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CCNG2 Gene

Pathways & Interactions for CCNG2 Gene

genes like me logo Genes that share pathways with CCNG2: view

Pathways by source for CCNG2 Gene

1 GeneTex pathway for CCNG2 Gene
2 KEGG pathways for CCNG2 Gene

Gene Ontology (GO) - Biological Process for CCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint TAS 8626390
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CCNG2: view

No data available for SIGNOR curated interactions for CCNG2 Gene

Drugs & Compounds for CCNG2 Gene

(3) Drugs for CCNG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCNG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNG2: view

Transcripts for CCNG2 Gene

Unigene Clusters for CCNG2 Gene

Cyclin G2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNG2 Gene

No ASD Table

Relevant External Links for CCNG2 Gene

GeneLoc Exon Structure for
CCNG2
ECgene alternative splicing isoforms for
CCNG2

Expression for CCNG2 Gene

mRNA expression in normal human tissues for CCNG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNG2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

SOURCE GeneReport for Unigene cluster for CCNG2 Gene Hs.740456

mRNA Expression by UniProt/SwissProt for CCNG2 Gene

Q16589-CCNG2_HUMAN
Tissue specificity: High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.
genes like me logo Genes that share expression patterns with CCNG2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCNG2 Gene

Orthologs for CCNG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNG2 36
  • 100 (a)
OneToOne
CCNG2 35
  • 99.81 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CCNG2 35
  • 91.67 (n)
  • 93.6 (a)
CCNG2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNG2 36
  • 94 (a)
OneToOne
CCNG2 35
  • 92.81 (n)
  • 93.88 (a)
mouse
(Mus musculus)
Mammalia Ccng2 16
Ccng2 36
  • 89 (a)
OneToOne
Ccng2 35
  • 85.23 (n)
  • 89.21 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNG2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNG2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccng2 35
  • 85.33 (n)
  • 90.09 (a)
chicken
(Gallus gallus)
Aves CCNG2 35
  • 78.26 (n)
  • 80.92 (a)
CCNG2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNG2 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15316 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccng2 35
  • 75.1 (n)
  • 78.4 (a)
Str.17220 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6763 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ccng2 35
  • 63.31 (n)
  • 62.26 (a)
ccng2 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001730 35
  • 39.22 (n)
  • 33.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycG 36
  • 17 (a)
OneToMany
Species with no ortholog for CCNG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNG2 Gene

ENSEMBL:
Gene Tree for CCNG2 (if available)
TreeFam:
Gene Tree for CCNG2 (if available)

Paralogs for CCNG2 Gene

Paralogs for CCNG2 Gene

(3) SIMAP similar genes for CCNG2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCNG2 Gene

genes like me logo Genes that share paralogs with CCNG2: view

Variants for CCNG2 Gene

Sequence variations from dbSNP and Humsavar for CCNG2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_014333 -
VAR_014334 -
rs4150053 -- 77,158,698(+) TGCTC(-/TC)AAGCA intron-variant
rs4150084 -- 77,163,751(+) TTTTT(A/G)GGAAA intron-variant
rs4150085 -- 77,164,236(+) TTGGG(A/G/T)GACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNG2 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv879500 CNV Loss 21882294
nsv290177 CNV Loss 16902084

Variation tolerance for CCNG2 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNG2 Gene

HapMap Linkage Disequilibrium report
CCNG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNG2 Gene

Disorders for CCNG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCNG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CCNG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNG2

Genetic Association Database (GAD)
CCNG2
Human Genome Epidemiology (HuGE) Navigator
CCNG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNG2
genes like me logo Genes that share disorders with CCNG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNG2 Gene

Publications for CCNG2 Gene

  1. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. (PMID: 8806701) Bates S.A. … Vousden K.H. (Oncogene 1996) 2 3 4 23 67
  2. Expression levels of cyclin G2, but not cyclin E, correlate with gastric cancer progression. (PMID: 19559447) Choi M.G. … Kim S. (J. Surg. Res. 2009) 3 23
  3. Cotylenin A, a new differentiation inducer, and rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2. (PMID: 18754885) Kasukabe T. … Honma Y. (Cancer Sci. 2008) 3 23
  4. Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7. (PMID: 18784254) Xu G. … Peng C. (Mol. Biol. Cell 2008) 3 23
  5. Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells. (PMID: 18025271) Le X.F. … Bast R.C. (Mol. Cancer Ther. 2007) 3 23

Products for CCNG2 Gene

Sources for CCNG2 Gene

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