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Aliases for CCNG2 Gene

Aliases for CCNG2 Gene

  • Cyclin G2 2 3 5
  • Cyclin-G2 3

External Ids for CCNG2 Gene

Previous GeneCards Identifiers for CCNG2 Gene

  • GC04P077988
  • GC04P078268
  • GC04P078471
  • GC04P078536
  • GC04P078435
  • GC04P078078
  • GC04P073832

Summaries for CCNG2 Gene

Entrez Gene Summary for CCNG2 Gene

  • The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNG2 Gene

CCNG2 (Cyclin G2) is a Protein Coding gene. Among its related pathways are DNA Damage Response (only ATM dependent) and Mitotic G1-G1/S phases. An important paralog of this gene is CCNG1.

UniProtKB/Swiss-Prot for CCNG2 Gene

  • May play a role in growth regulation and in negative regulation of cell cycle progression.

Gene Wiki entry for CCNG2 Gene

Additional gene information for CCNG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNG2 Gene

Genomics for CCNG2 Gene

GeneHancer (GH) Regulatory Elements for CCNG2 Gene

Promoters and enhancers for CCNG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I077151 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 558.2 -1.2 -1176 8.4 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC PPARGC1A CCNG2 LOC101928864 CNOT6L RPL7P17 RNU6-1187P GC04M077151
GH04I077092 Enhancer 1.1 FANTOM5 Ensembl ENCODE 14 -63.8 -63789 2.2 SOX6 JUN CEBPB CEBPG GABPA ZBTB5 CC2D1A POLR2A IKZF1 VEZF1 CCNG2 SEPT11 SOWAHB RPL7P17 GC04M077080
GH04I077095 Enhancer 1.1 FANTOM5 Ensembl ENCODE 13.3 -61.7 -61650 0.6 CTCF MZF1 SIN3A IRF4 RAD21 RFX5 SMC3 ZNF143 ZNF444 BCLAF1 CCNG2 RPL7P17 GC04M077080
GH04I077126 Enhancer 0.7 Ensembl ENCODE 12.6 -29.7 -29672 3 POLR2A FEZF1 RUNX3 SPI1 CCNG2 SOWAHB LOC339966 RNU6-1187P GC04M077151
GH04I077144 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -10.6 -10637 4.5 HDAC1 PKNOX1 ATF1 ZBTB40 ZNF335 ZNF766 ZNF366 FOS YY2 CEBPB CCNG2 CCNI GC04M077151 RNU6-1187P LOC339966
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCNG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCNG2 gene promoter:

Genomic Locations for CCNG2 Gene

Genomic Locations for CCNG2 Gene
chr4:77,157,151-77,433,388
(GRCh38/hg38)
Size:
276,238 bases
Orientation:
Plus strand
chr4:78,078,304-78,354,542
(GRCh37/hg19)

Genomic View for CCNG2 Gene

Genes around CCNG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNG2 Gene

Proteins for CCNG2 Gene

  • Protein details for CCNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16589-CCNG2_HUMAN
    Recommended name:
    Cyclin-G2
    Protein Accession:
    Q16589
    Secondary Accessions:
    • B4DF25
    • Q6FGA7
    • Q6FGC6

    Protein attributes for CCNG2 Gene

    Size:
    344 amino acids
    Molecular mass:
    38866 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNG2 Gene

Post-translational modifications for CCNG2 Gene

Other Protein References for CCNG2 Gene

No data available for DME Specific Peptides for CCNG2 Gene

Domains & Families for CCNG2 Gene

Gene Families for CCNG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CCNG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16589

UniProtKB/Swiss-Prot:

CCNG2_HUMAN :
  • Belongs to the cyclin family. Cyclin G subfamily.
Family:
  • Belongs to the cyclin family. Cyclin G subfamily.
genes like me logo Genes that share domains with CCNG2: view

Function for CCNG2 Gene

Molecular function for CCNG2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in growth regulation and in negative regulation of cell cycle progression.
UniProtKB/Swiss-Prot Induction:
Activated by actinomycin-D induced DNA damage.

Phenotypes for CCNG2 Gene

genes like me logo Genes that share phenotypes with CCNG2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNG2 Gene

Localization for CCNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNG2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNG2 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCNG2: view

Pathways & Interactions for CCNG2 Gene

genes like me logo Genes that share pathways with CCNG2: view

Pathways by source for CCNG2 Gene

1 GeneTex pathway for CCNG2 Gene
2 KEGG pathways for CCNG2 Gene

Gene Ontology (GO) - Biological Process for CCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint TAS 8626390
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CCNG2: view

No data available for SIGNOR curated interactions for CCNG2 Gene

Drugs & Compounds for CCNG2 Gene

(3) Drugs for CCNG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CCNG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNG2: view

Transcripts for CCNG2 Gene

Unigene Clusters for CCNG2 Gene

Cyclin G2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNG2 Gene

No ASD Table

Relevant External Links for CCNG2 Gene

GeneLoc Exon Structure for
CCNG2
ECgene alternative splicing isoforms for
CCNG2

Expression for CCNG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNG2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of CCNG2 Gene:

CCNG2

SOURCE GeneReport for Unigene cluster for CCNG2 Gene:

Hs.740456

mRNA Expression by UniProt/SwissProt for CCNG2 Gene:

Q16589-CCNG2_HUMAN
Tissue specificity: High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.

Evidence on tissue expression from TISSUES for CCNG2 Gene

  • Nervous system(4.8)
  • Blood(4.4)
  • Spleen(4.3)
  • Lymph node(2.2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with CCNG2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNG2 Gene

Orthologs for CCNG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNG2 33 34
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia CCNG2 33 34
  • 92.81 (n)
oppossum
(Monodelphis domestica)
Mammalia CCNG2 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNG2 33 34
  • 91.67 (n)
rat
(Rattus norvegicus)
Mammalia Ccng2 33
  • 85.33 (n)
mouse
(Mus musculus)
Mammalia Ccng2 33 16 34
  • 85.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNG2 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNG2 33 34
  • 78.26 (n)
lizard
(Anolis carolinensis)
Reptilia CCNG2 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccng2 33
  • 75.1 (n)
Str.17220 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15316 33
zebrafish
(Danio rerio)
Actinopterygii ccng2 33 34
  • 63.31 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6763 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001730 33
  • 39.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CycG 34
  • 17 (a)
OneToMany
Species where no ortholog for CCNG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNG2 Gene

ENSEMBL:
Gene Tree for CCNG2 (if available)
TreeFam:
Gene Tree for CCNG2 (if available)

Paralogs for CCNG2 Gene

Paralogs for CCNG2 Gene

(3) SIMAP similar genes for CCNG2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CCNG2 Gene

genes like me logo Genes that share paralogs with CCNG2: view

Variants for CCNG2 Gene

Sequence variations from dbSNP and Humsavar for CCNG2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000097436 -- 77,161,275(+) T/C intron_variant
rs1000210112 -- 77,156,996(+) C/T upstream_transcript_variant
rs1000242500 -- 77,156,846(+) C/T upstream_transcript_variant
rs1000278426 -- 77,160,420(+) A/G intron_variant
rs1000612531 -- 77,159,060(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCNG2 Gene

Variant ID Type Subtype PubMed ID
nsv290177 CNV deletion 16902084
nsv7363 OTHER inversion 18451855

Variation tolerance for CCNG2 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCNG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNG2 Gene

Disorders for CCNG2 Gene

Additional Disease Information for CCNG2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCNG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNG2 Gene

Publications for CCNG2 Gene

  1. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. (PMID: 8806701) Bates S … Vousden KH (Oncogene 1996) 2 3 4 22 58
  2. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. (PMID: 8626390) Horne MC … Wahl AF (The Journal of biological chemistry 1996) 3 4 22 58
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  4. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham JM … Goode EL (British journal of cancer 2009) 3 44 58
  5. Expression levels of cyclin G2, but not cyclin E, correlate with gastric cancer progression. (PMID: 19559447) Choi MG … Kim S (The Journal of surgical research 2009) 3 22 58

Products for CCNG2 Gene

Sources for CCNG2 Gene

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