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Aliases for CCNG2 Gene

Aliases for CCNG2 Gene

  • Cyclin G2 2 3
  • Cyclin-G2 3

External Ids for CCNG2 Gene

Previous GeneCards Identifiers for CCNG2 Gene

  • GC04P077988
  • GC04P078268
  • GC04P078471
  • GC04P078536
  • GC04P078435
  • GC04P078078
  • GC04P073832

Summaries for CCNG2 Gene

Entrez Gene Summary for CCNG2 Gene

  • The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNG2 Gene

CCNG2 (Cyclin G2) is a Protein Coding gene. Diseases associated with CCNG2 include thyroid lymphoma. Among its related pathways are FoxO signaling pathway and Wnt Signaling Pathway (WikiPathways). An important paralog of this gene is CCNI.

UniProtKB/Swiss-Prot for CCNG2 Gene

  • May play a role in growth regulation and in negative regulation of cell cycle progession

Gene Wiki entry for CCNG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNG2 Gene

Genomics for CCNG2 Gene

Regulatory Elements for CCNG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNG2 Gene

77,157,151 bp from pter
77,433,388 bp from pter
276,238 bases
Plus strand

Genomic View for CCNG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNG2 Gene

Proteins for CCNG2 Gene

  • Protein details for CCNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DF25
    • Q6FGA7
    • Q6FGC6

    Protein attributes for CCNG2 Gene

    344 amino acids
    Molecular mass:
    38866 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCNG2 Gene


neXtProt entry for CCNG2 Gene

Proteomics data for CCNG2 Gene at MOPED

Post-translational modifications for CCNG2 Gene

  • Ubiquitination at Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNG2 Gene

Antibody Products

No data available for DME Specific Peptides for CCNG2 Gene

Domains for CCNG2 Gene

Gene Families for CCNG2 Gene

Protein Domains for CCNG2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin G subfamily.
  • Belongs to the cyclin family. Cyclin G subfamily.
genes like me logo Genes that share domains with CCNG2: view

Function for CCNG2 Gene

Molecular function for CCNG2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in growth regulation and in negative regulation of cell cycle progession
UniProtKB/Swiss-Prot Induction:
Activated by actinomycin-D induced DNA damage

miRNA for CCNG2 Gene

miRTarBase miRNAs that target CCNG2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CCNG2 Gene

Localization for CCNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNG2 Gene


Subcellular locations from

Jensen Localization Image for CCNG2 Gene COMPARTMENTS Subcellular localization image for CCNG2 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCNG2: view

Pathways for CCNG2 Gene

genes like me logo Genes that share pathways with CCNG2: view

Pathways by source for CCNG2 Gene

2 KEGG pathways for CCNG2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CCNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint TAS 8626390
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CCNG2: view

Drugs for CCNG2 Gene

(4) Novoseek inferred chemical compound relationships for CCNG2 Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 44.2 6
rapamycin 33.2 6
estradiol 6.25 2
estrogen 6.18 3
genes like me logo Genes that share compounds with CCNG2: view

Transcripts for CCNG2 Gene

Unigene Clusters for CCNG2 Gene

Cyclin G2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNG2 Gene

No ASD Table

Relevant External Links for CCNG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNG2 Gene

mRNA expression in normal human tissues for CCNG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNG2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.2).

SOURCE GeneReport for Unigene cluster for CCNG2 Gene Hs.740456

mRNA Expression by UniProt/SwissProt for CCNG2 Gene

Tissue specificity: High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle
genes like me logo Genes that share expressions with CCNG2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for CCNG2 Gene

Orthologs for CCNG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCNG2 35
  • 91.67 (n)
  • 93.6 (a)
CCNG2 36
  • 94 (a)
(Canis familiaris)
Mammalia CCNG2 35
  • 92.81 (n)
  • 93.88 (a)
CCNG2 36
  • 94 (a)
(Mus musculus)
Mammalia Ccng2 35
  • 85.23 (n)
  • 89.21 (a)
Ccng2 16
Ccng2 36
  • 89 (a)
(Pan troglodytes)
Mammalia CCNG2 35
  • 99.81 (n)
  • 100 (a)
CCNG2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ccng2 35
  • 85.33 (n)
  • 90.09 (a)
(Monodelphis domestica)
Mammalia CCNG2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CCNG2 36
  • 80 (a)
(Gallus gallus)
Aves CCNG2 35
  • 78.26 (n)
  • 80.92 (a)
CCNG2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia CCNG2 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccng2 35
  • 75.1 (n)
  • 78.4 (a)
Str.17220 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15316 35
(Danio rerio)
Actinopterygii -- 35
ccng2 35
  • 63.31 (n)
  • 62.26 (a)
ccng2 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6763 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001730 35
  • 39.22 (n)
  • 33.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycG 36
  • 17 (a)
Species with no ortholog for CCNG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNG2 Gene

Gene Tree for CCNG2 (if available)
Gene Tree for CCNG2 (if available)

Paralogs for CCNG2 Gene

Paralogs for CCNG2 Gene

(3) SIMAP similar genes for CCNG2 Gene using alignment to 3 proteins: Pseudogenes for CCNG2 Gene

genes like me logo Genes that share paralogs with CCNG2: view

Variants for CCNG2 Gene

Sequence variations from dbSNP and Humsavar for CCNG2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs62303569 -- 77,162,373(+) ACTTT(G/T)GGATT intron-variant
rs59628477 -- 77,162,402(+) TTTTT(-/T)GAGAC intron-variant
rs59117192 -- 77,161,118(+) TTTTT(-/TTT)GGAGA intron-variant
rs36101294 -- 77,170,343(+) AGCCC(-/T)TGAGA downstream-variant-500B
rs35801868 -- 77,162,377(+) TGGGA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNG2 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv879500 CNV Loss 21882294
nsv290177 CNV Loss 16902084

Relevant External Links for CCNG2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNG2 Gene

Disorders for CCNG2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CCNG2 Gene in MalaCards »

(1) Disease for CCNG2 Gene

(5) Novoseek inferred disease relationships for CCNG2 Gene

Disease -log(P) Hits PubMed IDs
cancer 21.6 7
breast cancer 11 4
carcinoma squamous cell 10.6 1
tumors 0 1
carcinoma 0 4

Relevant External Links for CCNG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CCNG2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CCNG2 Gene

Publications for CCNG2 Gene

  1. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. (PMID: 8806701) Bates S.A. … Vousden K.H. (Oncogene 1996) 2 3 4 23
  2. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. (PMID: 8626390) Horne M.C. … Wahl A.F. (J. Biol. Chem. 1996) 3 4 23
  3. [Ectopic expression of cyclin G2 inhibits cell proliferation in HeLa cancer cell line]. (PMID: 12452053) Tian Y.L. … Zhang X. (Ai Zheng 2002) 3 23
  4. Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells. (PMID: 18025271) Le X.F. … Bast R.C. (Mol. Cancer Ther. 2007) 3 23
  5. Cotylenin A, a new differentiation inducer, and rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2. (PMID: 18754885) Kasukabe T. … Honma Y. (Cancer Sci. 2008) 3 23

Products for CCNG2 Gene

Sources for CCNG2 Gene

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