External Ids for CCNG2 Gene
Previous GeneCards Identifiers for CCNG2 Gene
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNG2 Gene
CCNG2 (Cyclin G2) is a Protein Coding gene. Diseases associated with CCNG2 include Esophageal Cancer. Among its related pathways are p53 signaling pathway and FoxO signaling pathway. An important paralog of this gene is CCNG1.
UniProtKB/Swiss-Prot for CCNG2 Gene
May play a role in growth regulation and in negative regulation of cell cycle progession.