Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCNG1 Gene

Aliases for CCNG1 Gene

  • Cyclin G1 2 3 5
  • Cyclin-G 3 4
  • CCNG 3 4
  • Cyclin-G1 3
  • CYCG1 4

External Ids for CCNG1 Gene

Previous HGNC Symbols for CCNG1 Gene

  • CCNG

Previous GeneCards Identifiers for CCNG1 Gene

  • GC05P163067
  • GC05P162800
  • GC05P162845
  • GC05P162797
  • GC05P162864
  • GC05P157964

Summaries for CCNG1 Gene

Entrez Gene Summary for CCNG1 Gene

  • The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNG1 Gene

CCNG1 (Cyclin G1) is a Protein Coding gene. Diseases associated with CCNG1 include Mantle Cell Lymphoma and Breast Cancer. Among its related pathways are Regulation of TP53 Activity and Spinal Cord Injury. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is CCNG2.

UniProtKB/Swiss-Prot for CCNG1 Gene

  • May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).

Gene Wiki entry for CCNG1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNG1 Gene

Genomics for CCNG1 Gene

Regulatory Elements for CCNG1 Gene

Enhancers for CCNG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G163457 1.4 ENCODE dbSUPER 18.7 +23.4 23383 6.0 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CCNG1 MAT2B HMMR-AS1 LOC105377700 NUDCD2 HMMR
GH05G163408 0.9 Ensembl ENCODE 11.3 -28.6 -28596 1.0 CTCF ZNF654 PKNOX1 WRNIP1 TEAD2 TRIM22 REST RAD21 RFX5 PATZ1 CCNG1 LOC105377700 ENSG00000250114 GC05P163387
GH05G163502 1.4 ENCODE dbSUPER 5 +69.2 69225 8.7 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 MAT2B HMMR CCNG1 NUDCD2 GC05P163619
GH05G163407 0.4 Ensembl 10.9 -30.0 -29970 0.6 ZNF680 FOXP2 CCNG1 LOC105377700 ENSG00000250114 GC05P163387
GH05G163515 0.4 dbSUPER 5.4 +80.2 80197 3.1 PAF1 HMMR-AS1 CCNG1 MAT2B GC05P163619
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNG1 on UCSC Golden Path with GeneCards custom track

Promoters for CCNG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000190053 730 2401 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766

Genomic Location for CCNG1 Gene

Chromosome:
5
Start:
163,437,270 bp from pter
End:
163,446,151 bp from pter
Size:
8,882 bases
Orientation:
Plus strand

Genomic View for CCNG1 Gene

Genes around CCNG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNG1 Gene

Proteins for CCNG1 Gene

  • Protein details for CCNG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51959-CCNG1_HUMAN
    Recommended name:
    Cyclin-G1
    Protein Accession:
    P51959
    Secondary Accessions:
    • B2R7B2
    • B4DLW7
    • D3DQK7
    • Q15757
    • Q96L32

    Protein attributes for CCNG1 Gene

    Size:
    295 amino acids
    Molecular mass:
    34074 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB03903.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA54821.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNG1 Gene

Post-translational modifications for CCNG1 Gene

  • Ubiquitination at posLast=247247
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNG1 Gene

No data available for DME Specific Peptides for CCNG1 Gene

Domains & Families for CCNG1 Gene

Gene Families for CCNG1 Gene

Protein Domains for CCNG1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNG1 Gene

Graphical View of Domain Structure for InterPro Entry

P51959

UniProtKB/Swiss-Prot:

CCNG1_HUMAN :
  • Belongs to the cyclin family. Cyclin G subfamily.
Family:
  • Belongs to the cyclin family. Cyclin G subfamily.
genes like me logo Genes that share domains with CCNG1: view

Function for CCNG1 Gene

Molecular function for CCNG1 Gene

GENATLAS Biochemistry:
cyclin G,modulator of the cell cycle and apoptosis,transcriptional target of p53 tumor suppressor gene
UniProtKB/Swiss-Prot Function:
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
UniProtKB/Swiss-Prot Induction:
Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.

Gene Ontology (GO) - Molecular Function for CCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17245430
genes like me logo Genes that share ontologies with CCNG1: view
genes like me logo Genes that share phenotypes with CCNG1: view

Animal Models for CCNG1 Gene

MGI Knock Outs for CCNG1:

Animal Model Products

miRNA for CCNG1 Gene

miRTarBase miRNAs that target CCNG1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCNG1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNG1 Gene

Localization for CCNG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNG1 Gene

Nucleus. Note=DNA replication foci after DNA damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNG1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CCNG1: view

Pathways & Interactions for CCNG1 Gene

genes like me logo Genes that share pathways with CCNG1: view

Gene Ontology (GO) - Biological Process for CCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8626390
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CCNG1: view

No data available for SIGNOR curated interactions for CCNG1 Gene

Drugs & Compounds for CCNG1 Gene

(14) Drugs for CCNG1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MX-DNG1 Pharma 0

(3) Additional Compounds for CCNG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNG1: view

Transcripts for CCNG1 Gene

Unigene Clusters for CCNG1 Gene

Cyclin G1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCNG1

Alternative Splicing Database (ASD) splice patterns (SP) for CCNG1 Gene

No ASD Table

Relevant External Links for CCNG1 Gene

GeneLoc Exon Structure for
CCNG1
ECgene alternative splicing isoforms for
CCNG1

Expression for CCNG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNG1 Gene

Protein differential expression in normal tissues from HIPED for CCNG1 Gene

This gene is overexpressed in Fetal heart (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNG1 Gene



Protein tissue co-expression partners for CCNG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNG1 Gene:

CCNG1

SOURCE GeneReport for Unigene cluster for CCNG1 Gene:

Hs.79101

mRNA Expression by UniProt/SwissProt for CCNG1 Gene:

P51959-CCNG1_HUMAN
Tissue specificity: High levels in skeletal muscle, ovary, kidney and colon.

Evidence on tissue expression from TISSUES for CCNG1 Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Spleen(4.3)
  • Liver(3.4)
  • Intestine(2.4)
  • Lung(2.4)
  • Skin(2.4)
  • Kidney(2.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CCNG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNG1 Gene

Orthologs for CCNG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNG1 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia CCNG1 34 35
  • 95.14 (n)
cow
(Bos Taurus)
Mammalia CCNG1 34 35
  • 93.33 (n)
oppossum
(Monodelphis domestica)
Mammalia CCNG1 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccng1 34 16 35
  • 89.65 (n)
rat
(Rattus norvegicus)
Mammalia Ccng1 34
  • 88.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNG1 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNG1 34 35
  • 76.03 (n)
lizard
(Anolis carolinensis)
Reptilia CCNG1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccng1 34
  • 72.83 (n)
Str.1803 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53060 34
zebrafish
(Danio rerio)
Actinopterygii ccng1 34 35
  • 64.16 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10949 34
fruit fly
(Drosophila melanogaster)
Insecta CycG 34 35
  • 43.85 (n)
Species where no ortholog for CCNG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNG1 Gene

ENSEMBL:
Gene Tree for CCNG1 (if available)
TreeFam:
Gene Tree for CCNG1 (if available)

Paralogs for CCNG1 Gene

Paralogs for CCNG1 Gene

(3) SIMAP similar genes for CCNG1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CCNG1 Gene

genes like me logo Genes that share paralogs with CCNG1: view

Variants for CCNG1 Gene

Sequence variations from dbSNP and Humsavar for CCNG1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000804448 -- 163,437,840(+) AGGTG(C/G)GGGTG intron-variant, upstream-variant-2KB
rs1000831672 -- 163,442,534(+) AACTC(A/G)CCTTC nc-transcript-variant, reference, missense
rs1000945737 -- 163,445,448(+) TTAGC(C/T)GACAC downstream-variant-500B
rs1000975358 -- 163,445,060(+) AACTC(C/T)TTTAG downstream-variant-500B
rs1001124539 -- 163,442,730(+) GCCTT(C/T)ACTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNG1 Gene

Variant ID Type Subtype PubMed ID
esv3607453 CNV gain 21293372
nsv1017056 CNV gain 25217958
nsv1018494 CNV gain 25217958
nsv1029437 CNV gain 25217958
nsv600192 CNV loss 21841781
nsv830538 CNV gain+loss 17160897

Variation tolerance for CCNG1 Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNG1 Gene

Disorders for CCNG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCNG1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mantle cell lymphoma
  • lymphoma, mantle cell
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search CCNG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNG1

Genetic Association Database (GAD)
CCNG1
Human Genome Epidemiology (HuGE) Navigator
CCNG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNG1
genes like me logo Genes that share disorders with CCNG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNG1 Gene

Publications for CCNG1 Gene

  1. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. (PMID: 8806701) Bates S.A. … Vousden K.H. (Oncogene 1996) 2 3 4 22 64
  2. Structure and chromosomal assignment of the human cyclin G gene. (PMID: 8954786) Endo Y. … Nojima H. (Genomics 1996) 2 3 4 22 64
  3. Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. (PMID: 10196184) Reimer C.L. … Lee S.W. (J. Biol. Chem. 1999) 3 4 22 64
  4. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. (PMID: 8626390) Horne M.C. … Wahl A.F. (J. Biol. Chem. 1996) 3 4 22 64
  5. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham J.M. … Goode E.L. (Br. J. Cancer 2009) 3 46 64

Products for CCNG1 Gene

  • Addgene plasmids for CCNG1

Sources for CCNG1 Gene

Content
Loading form....