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CCNG1 Gene

protein-coding   GIFtS: 60
GCID: GC05P162864

Cyclin G1


(Previous symbol: CCNG)
  See CCNG1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin G11 2
CCNG1 2 3
cyclin-G2
cyclin-G12
CYCG13
Cyclin-G3

External Ids:    HGNC: 15921   Entrez Gene: 9002   Ensembl: ENSG000001133287   OMIM: 6015785   UniProtKB: P519593   

Export aliases for CCNG1 gene to outside databases

Previous GC identifers: GC05P163067 GC05P163457 GC05P162800 GC05P162845 GC05P162797 GC05P157964


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNG1 Gene:
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by
cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the
cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family
members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants
encoding the same protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNG1 Gene:
CCNG1 (cyclin G1) is a protein-coding gene. Diseases associated with CCNG1 include mantle cell lymphoma. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is CCNI2.

UniProtKB/Swiss-Prot: CCNG1_HUMAN, P51959
Function: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage.
May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity)

Gene Wiki entry for CCNG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNG1 gene promoter:
         Oct-B1   POU2F1   oct-B3   POU2F1a   c-Myb   Lmo2   STAT3   CUTL1   POU2F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNG1 promoter sequence
   Search Chromatin IP Primers for CCNG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32-q34   Ensembl cytogenetic band:  5q34   HGNC cytogenetic band: 5q32-q34

CCNG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNG1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P162864:  view genomic region     (about GC identifiers)

Start:
162,864,575 bp from pter      End:
162,873,157 bp from pter
Size:
8,583 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCNG1_HUMAN, P51959 (See protein sequence)
Recommended Name: Cyclin-G1  
Size: 295 amino acids; 34074 Da
Developmental stage: Very low levels in normal cells during G1 phase, which increase as cells enter the S phase
and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found
throughout the cell cycle
Sequence caution: Sequence=AAB03903.1; Type=Erroneous initiation; Sequence=CAA54821.1; Type=Erroneous initiation;
Secondary accessions: B2R7B2 D3DQK7 Q15757 Q96L32

Explore the universe of human proteins at neXtProt for CCNG1: NX_P51959

Explore proteomics data for CCNG1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys247
  • Modification sites at PhosphoSitePlus

  • See CCNG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004051.1  NP_954854.1  

    ENSEMBL proteins: 
     ENSP00000424315   ENSP00000344635   ENSP00000424141   ENSP00000423791   ENSP00000421132  
     ENSP00000422379   ENSP00000427086   ENSP00000377506  

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    Novus Biologicals CCNG1 Proteins
    Novus Biologicals CCNG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCNG1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCNG1 

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    Search eBioscience for ELISAs for CCNG1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR028860 CCNG1

    Graphical View of Domain Structure for InterPro Entry P51959

    ProtoNet protein and cluster: P51959

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNG1_HUMAN, P51959
    Similarity: Belongs to the cyclin family. Cyclin G subfamily


    Find genes that share domains with CCNG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNG1_HUMAN, P51959
    Function: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage.
    May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity)
    Induction: Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage

         Genatlas biochemistry entry for CCNG1:
    cyclin G,modulator of the cell cycle and apoptosis,transcriptional target of p53 tumor suppressor gene

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with CCNG1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccng1):
     cellular  digestive/alimentary  liver/biliary system  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with CCNG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CCNG1: Ccng1tm1Noj Ccng1tm1Sst

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCNG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCNG1:
    hsa-let-7a-5p (MIRT052643), hsa-mir-21-5p (MIRT031062), hsa-let-7b-5p (MIRT052358), hsa-mir-17-3p (MIRT050754), hsa-mir-181a-5p (MIRT025126), hsa-mir-122-5p (MIRT003006), hsa-mir-24-3p (MIRT050379), hsa-let-7e-5p (MIRT051584), hsa-mir-9-5p (MIRT006782), hsa-let-7c-5p (MIRT051874), hsa-mir-100-5p (MIRT048390), hsa-let-7f-5p (MIRT051412), hsa-mir-197-3p (MIRT048101)

    Block miRNA regulation of human, mouse, rat CCNG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNG1 (see all 38):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-513a-5p hsa-miR-128 hsa-miR-605 hsa-miR-488 hsa-miR-3171 hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidCCNG1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNG1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCNG1 (NM_004060)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNG1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNG1_HUMAN, P51959: Nucleus. Note=DNA replication foci after DNA damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with CCNG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNG1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    Breast Cancer Regulation by Stathmin10.58
    2p53 signaling pathway
    p53 signaling pathway0.41
    3Spinal Cord Injury
    Spinal Cord Injury
    4p53 pathway
    p53 pathway
    5MicroRNAs in cancer
    MicroRNAs in cancer


    Find genes that share SuperPaths with CCNG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNG1
        Breast Cancer Regulation by Stathmin1
    GADD45 Pathway
    Pancreatic Adenocarcinoma

    3 BioSystems Pathways for CCNG1
        Spinal Cord Injury
    Direct p53 effectors
    p53 pathway


    2 Kegg Pathways  (Kegg details for CCNG1):
        p53 signaling pathway
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNG1: 
              Nephrotoxicity in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNG1 (P519591, 2, 3 ENSP000003446354) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AP301532, 3, ENSP000003248044MINT-4299123 I2D: score=1 STRING: ENSP00000324804
    TNIP1Q150251, 3, ENSP000003178914EBI-3905829,EBI-357849 I2D: score=1 STRING: ENSP00000317891
    TP53P046373, ENSP000002693054I2D: score=4 STRING: ENSP00000269305
    GAKO149763, ENSP000003144994I2D: score=3 STRING: ENSP00000314499
    MDM2Q009873, ENSP000004172814I2D: score=3 STRING: ENSP00000417281
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS8626390
    GO:0006949syncytium formation IEA--
    GO:0007067mitosis IEA--
    GO:0007095mitotic G2 DNA damage checkpoint IEA--
    GO:0007420brain development IEA--

    Find genes that share ontologies with CCNG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNG1

    Selected Novoseek inferred chemical compound relationships for CCNG1 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mimosine 43.9 1 10530763 (1)
    retinoid 11 1 11795432 (1)
    rapamycin 9.68 1 8268127 (1)
    calcium 2.06 1 7954463 (1)
    glucose 1.49 1 7954463 (1)
    estrogen 0.945 1 11109161 (1)
    steroid 0 2 7981461 (1)
    threonine 0 3 18981217 (1)
    tyrosine 0 2 9164677 (1), 12393265 (1)
    actinomycin d 0 2 8806701 (1)



    Find genes that share compounds with CCNG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNG1 gene (2 alternative transcripts): 
    NM_004060.3  NM_199246.1  

    Unigene Cluster for CCNG1:

    Cyclin G1
    Hs.79101  [show with all ESTs]
    Unigene Representative Sequence: NM_004060
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512163 ENST00000506186 ENST00000340828(uc011dek.1 uc003lzb.3 uc011del.2 uc003lzc.3)
    ENST00000511683 ENST00000510097 ENST00000511490 ENST00000510664 ENST00000512532
    ENST00000504553 ENST00000514367 ENST00000509143 ENST00000509425 ENST00000393929

    miRNA
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    Block miRNA regulation of human, mouse, rat CCNG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNG1 (see all 38):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-513a-5p hsa-miR-128 hsa-miR-605 hsa-miR-488 hsa-miR-3171 hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidCCNG1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCNG1 (NM_004060)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNG1
      QuantiTect SYBR Green Assays in human, mouse, rat CCNG1
      QuantiFast Probe-based Assays in human, mouse, rat CCNG1

    Additional mRNA sequence: 

    AK297190.1 AK312913.1 AK316234.1 BC000196.1 BC007093.2 BT007134.1 D78341.1 L49504.1 
    U47413.1 U53328.1 X77794.1 

    22 DOTS entries:

    DT.91760551  DT.100710854  DT.95358160  DT.95335621  DT.100816761  DT.100662820  DT.100816772  DT.120888767 
    DT.100718516  DT.120888753  DT.102820239  DT.120888779  DT.100816762  DT.100816768  DT.120888731  DT.120888732 
    DT.121364974  DT.75162503  DT.91683075  DT.91760553  DT.92022397  DT.120888745 

    Selected AceView cDNA sequences (see all 507):

    CB119891 AI571088 AU154072 CA393880 BM471186 BQ653527 AW304999 AI245036 
    AI831894 AI928044 AI423572 AW304929 AW955657 BQ000370 AW058380 AL516671 
    BM470061 BE890159 W20044 AA947227 AW016735 BU539752 BQ882968 AA639763 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATGGGT
    CCNG1 Expression
    About this image


    CCNG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    CCNG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79101

    UniProtKB/Swiss-Prot: CCNG1_HUMAN, P51959
    Tissue specificity: High levels in skeletal muscle, ovary, kidney and colon

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNG1: 
              Nephrotoxicity in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat

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    QuantiTect SYBR Green Assays in human, mouse, rat CCNG1
    QuantiFast Probe-based Assays in human, mouse, rat CCNG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCNG1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccng11 , 5 cyclin G11, 5 89.65(n)1
    92.83(a)1
      11 (24.42 cM)5
    124501  NM_009831.21  NP_033961.11 
     407485525 
    chicken
    (Gallus gallus)
    Aves CCNG11 cyclin G1 76.03(n)
    84.93(a)
      416161  XM_414493.4  XP_414493.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNG16
    cyclin G1
    71(a)
    1 ↔ 1
    1(108052719-108068210)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC530602 similar to cyclin G1 74.12(n)    BC049393.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccng12 cyclin G1 72.42(n)   171473  AY423016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycG1 Cyclin G 43.85(n)
    34.84(a)
      43724  NM_001276217.1  NP_001263146.1 


    ENSEMBL Gene Tree for CCNG1 (if available)
    TreeFam Gene Tree for CCNG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNG1 gene
    CCNI22  CCNG22  CCNI2  
    3 SIMAP similar genes for CCNG1 using alignment to 6 protein entries:     CCNG1_HUMAN (see all proteins):
    DKFZp686M0576    CCNG2    CCNI

    Find genes that share paralogs with CCNG1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCNG1
    PGOHUM00000243779


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNG1 (see all 236)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149175411,2
    F--162862603(+) CTTCTC/TATTGT 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1381189861,2
    --162862702(+) TTCTAA/CAGTCT 2 -- us2k10--------
    rs178807181,2
    C,F--162862754(+) GGGTAC/TCAGTC 2 -- us2k13Minor allele frequency- T:0.02NS NA WA 284
    rs2993251,2
    C,F,A,H--162862817(+) TATTCG/ATGCTT 2 -- us2k115Minor allele frequency- A:0.31NS EA NA WA CSA 806
    rs100719641,2
    C,F--162862903(+) ATCTCG/AGCTCA 2 -- us2k15Minor allele frequency- A:0.47NA NS WA CSA 172
    rs2993241,2
    C,F,A--162863009(+) ttgtaT/Ctttca 2 -- us2k17Minor allele frequency- C:0.19NS NA WA 178
    rs178845701,2
    C,F--162863023(+) GAGACG/AGGGTT 2 -- us2k11Minor allele frequency- A:0.03NS 166
    rs1926181941,2
    --162863109(+) GATTAC/TAGGTG 2 -- us2k10--------
    rs178841191,2
    C,F--162863132(+) CCCAGC/GCTGCC 2 -- us2k11Minor allele frequency- G:0.02NS 166
    rs178819761,2
    C,F--162863171(+) TTTTTT/AAAAAA 2 -- us2k11Minor allele frequency- A:0.02NS 166

    HapMap Linkage Disequilibrium report for CCNG1 (162864575 - 162873157 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCNG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830538CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNG1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601578    OMIM disorders: --

    1 disease for CCNG1:    
    About MalaCards
    mantle cell lymphoma


    Find genes that share disorders with CCNG1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCNG1 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 79.5 21 7797074 (1), 10477583 (1), 8594075 (1), 8943373 (1) (see all 20)
    lymphoma mantle-cell 48.6 1 9209645 (1)
    tumors 41.3 38 8954786 (2), 12634633 (2), 12556559 (2), 10196184 (2) (see all 29)
    cancer 37 15 11496300 (1), 12895470 (1), 17616664 (1), 20384524 (1) (see all 15)
    osteosarcoma 30.9 7 7585620 (2), 19532136 (1), 9852531 (1), 10194136 (1) (see all 5)
    lymphoma 29.3 12 11291051 (3), 11035575 (1), 19757306 (1), 9499444 (1) (see all 7)
    breast cancer 21.9 6 9178893 (1), 8614416 (1), 9194584 (1), 9671407 (1) (see all 6)
    carcinoma squamous cell 20.7 2 9813719 (1), 11115554 (1)
    neoplastic transformation 18.1 1 9579467 (1)
    burkitt lymphoma 15.9 1 8626390 (1)

    Genetic Association Database (GAD): CCNG1
    Human Genome Epidemiology (HuGE) Navigator: CCNG1 (1 document)

    Export disorders for CCNG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNG1 gene, integrated from 10 sources (see all 259):
    (articles sorted by number of sources associating them with CCNG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and chromosomal assignment of the human cyclin G gene. (PubMed id 8954786)1, 2, 3, 9 Endo Y.... Nojima H. (Genomics 1996)
    2. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. (PubMed id 8806701)1, 2, 3, 9 Bates S.A.... Vousden K.H. (Oncogene 1996)
    3. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. (PubMed id 8626390)1, 2, 9 Horne M.C....Wahl A.F. (J. Biol. Chem. 1996)
    4. Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. (PubMed id 10196184)1, 2, 9 Reimer C.L.... Lee S.W. (J. Biol. Chem. 1999)
    5. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1. (PubMed id 16322753)1, 9 Seo H.R....Lee Y.S. (Cell Death Differ. 2006)
    8. Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation. (PubMed id 12642871)1, 9 Ohtsuka T....Lee S.W. (Oncogene 2003)
    9. The negative role of cyclin G in ATM-dependent p53 activation. (PubMed id 15077171)1, 9 Ohtsuka T....Lee S.W. (Oncogene 2004)
    10. Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways. (PubMed id 12556559)1, 9 Zhao L....Quelle D.E. (Mol. Cancer Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 900 HGNC: 1592 AceView: CCNG1 Ensembl:ENSG00000113328 euGenes: HUgn900
    ECgene: CCNG1 Kegg: 900 H-InvDB: CCNG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNG1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccng1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNG1 gene:
    Search GeneIP for patents involving CCNG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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