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Aliases for CCNG1 Gene

Aliases for CCNG1 Gene

  • Cyclin G1 2 3 5
  • Cyclin-G 3 4
  • CCNG 3 4
  • CYCG1 4

External Ids for CCNG1 Gene

Previous HGNC Symbols for CCNG1 Gene

  • CCNG

Previous GeneCards Identifiers for CCNG1 Gene

  • GC05P163067
  • GC05P162800
  • GC05P162845
  • GC05P162797
  • GC05P162864
  • GC05P157964

Summaries for CCNG1 Gene

Entrez Gene Summary for CCNG1 Gene

  • The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNG1 Gene

CCNG1 (Cyclin G1) is a Protein Coding gene. Diseases associated with CCNG1 include Breast Cancer and Severe Combined Immune Deficiency. Among its related pathways are Gene Expression and GPCR Pathway. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is CCNI.

UniProtKB/Swiss-Prot for CCNG1 Gene

  • May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).

Gene Wiki entry for CCNG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNG1 Gene

Genomics for CCNG1 Gene

Regulatory Elements for CCNG1 Gene

Enhancers for CCNG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCNG1 on UCSC Golden Path with GeneCards custom track

Promoters for CCNG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNG1 Gene

163,437,270 bp from pter
163,446,151 bp from pter
8,882 bases
Plus strand

Genomic View for CCNG1 Gene

Genes around CCNG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNG1 Gene

Proteins for CCNG1 Gene

  • Protein details for CCNG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R7B2
    • B4DLW7
    • D3DQK7
    • Q15757
    • Q96L32

    Protein attributes for CCNG1 Gene

    295 amino acids
    Molecular mass:
    34074 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB03903.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA54821.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNG1 Gene


neXtProt entry for CCNG1 Gene

Proteomics data for CCNG1 Gene at MOPED

Post-translational modifications for CCNG1 Gene

  • Ubiquitination at Lys 247
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNG1 Gene

No data available for DME Specific Peptides for CCNG1 Gene

Domains & Families for CCNG1 Gene

Gene Families for CCNG1 Gene

Protein Domains for CCNG1 Gene


Suggested Antigen Peptide Sequences for CCNG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin G subfamily.
  • Belongs to the cyclin family. Cyclin G subfamily.
genes like me logo Genes that share domains with CCNG1: view

Function for CCNG1 Gene

Molecular function for CCNG1 Gene

GENATLAS Biochemistry:
cyclin G,modulator of the cell cycle and apoptosis,transcriptional target of p53 tumor suppressor gene
UniProtKB/Swiss-Prot Function:
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
UniProtKB/Swiss-Prot Induction:
Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.
genes like me logo Genes that share phenotypes with CCNG1: view

Animal Models for CCNG1 Gene

MGI Knock Outs for CCNG1:

Animal Model Products

miRNA for CCNG1 Gene

miRTarBase miRNAs that target CCNG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNG1 Gene

Localization for CCNG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNG1 Gene

Nucleus. Note=DNA replication foci after DNA damage.

Subcellular locations from

Jensen Localization Image for CCNG1 Gene COMPARTMENTS Subcellular localization image for CCNG1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CCNG1 Gene

Pathways & Interactions for CCNG1 Gene

genes like me logo Genes that share pathways with CCNG1: view

Gene Ontology (GO) - Biological Process for CCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8626390
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CCNG1: view

No data available for SIGNOR curated interactions for CCNG1 Gene

Drugs & Compounds for CCNG1 Gene

(12) Drugs for CCNG1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MX-DNG1 Pharma 0

(5) Additional Compounds for CCNG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCNG1: view

Transcripts for CCNG1 Gene

Unigene Clusters for CCNG1 Gene

Cyclin G1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNG1 Gene

No ASD Table

Relevant External Links for CCNG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNG1 Gene

mRNA expression in normal human tissues for CCNG1 Gene

Protein differential expression in normal tissues from HIPED for CCNG1 Gene

This gene is overexpressed in Fetal heart (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNG1 Gene

SOURCE GeneReport for Unigene cluster for CCNG1 Gene Hs.79101

mRNA Expression by UniProt/SwissProt for CCNG1 Gene

Tissue specificity: High levels in skeletal muscle, ovary, kidney and colon.
genes like me logo Genes that share expression patterns with CCNG1: view

Protein tissue co-expression partners for CCNG1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CCNG1 Gene

Orthologs for CCNG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCNG1 35
  • 93.33 (n)
  • 94.24 (a)
CCNG1 36
  • 94 (a)
(Canis familiaris)
Mammalia CCNG1 35
  • 95.14 (n)
  • 97.63 (a)
CCNG1 36
  • 98 (a)
(Mus musculus)
Mammalia Ccng1 35
  • 89.65 (n)
  • 92.83 (a)
Ccng1 16
Ccng1 36
  • 93 (a)
(Pan troglodytes)
Mammalia CCNG1 35
  • 99.44 (n)
  • 100 (a)
CCNG1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ccng1 35
  • 88.77 (n)
  • 94.5 (a)
(Monodelphis domestica)
Mammalia CCNG1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CCNG1 36
  • 85 (a)
(Gallus gallus)
Aves CCNG1 35
  • 76.03 (n)
  • 84.93 (a)
CCNG1 36
  • 84 (a)
(Anolis carolinensis)
Reptilia CCNG1 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccng1 35
  • 72.83 (n)
  • 77.05 (a)
Str.1803 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53060 35
(Danio rerio)
Actinopterygii ccng1 35
  • 64.16 (n)
  • 63.7 (a)
ccng1 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10949 35
fruit fly
(Drosophila melanogaster)
Insecta CycG 35
  • 43.85 (n)
  • 34.84 (a)
CycG 36
  • 16 (a)
Species with no ortholog for CCNG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNG1 Gene

Gene Tree for CCNG1 (if available)
Gene Tree for CCNG1 (if available)

Paralogs for CCNG1 Gene

Paralogs for CCNG1 Gene

(3) SIMAP similar genes for CCNG1 Gene using alignment to 6 proteins: Pseudogenes for CCNG1 Gene

genes like me logo Genes that share paralogs with CCNG1: view

Variants for CCNG1 Gene

Sequence variations from dbSNP and Humsavar for CCNG1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2069352 - 163,441,899(+) GCATT(A/C/T)ATTTT nc-transcript-variant, reference, missense
rs11541970 - 163,441,904(+) AATTT(G/T)GAAAG nc-transcript-variant, reference, missense
rs918530 -- 163,442,062(+) GCATT(G/T)TCTAT nc-transcript-variant, reference, missense
rs299321 -- 163,443,242(+) gggag(A/G)cggag intron-variant
rs299322 -- 163,439,542(+) ATTTT(C/T)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNG1 Gene

Variant ID Type Subtype PubMed ID
nsv830538 CNV Gain+Loss 17160897

Variation tolerance for CCNG1 Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCNG1 Gene

Disorders for CCNG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCNG1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
severe combined immune deficiency
  • severe combined immunodeficiency
- elite association - COSMIC cancer census association via MalaCards
Search CCNG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCNG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNG1 Gene

Publications for CCNG1 Gene

  1. Structure and chromosomal assignment of the human cyclin G gene. (PMID: 8954786) Endo Y. … Nojima H. (Genomics 1996) 2 3 4 23 67
  2. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. (PMID: 8806701) Bates S.A. … Vousden K.H. (Oncogene 1996) 2 3 23
  3. Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A. (PMID: 18981217) Li H. … Prives C. (Mol. Cell. Biol. 2009) 3 23
  4. MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. (PMID: 19584283) Fornari F. … Bolondi L. (Cancer Res. 2009) 3 23
  5. [Expression of P27(kip1) and cyclin G in patients with acute leukemia and its correlation]. (PMID: 19698214) Chen H.Y. … Hu J.D. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009) 3 23

Products for CCNG1 Gene

Sources for CCNG1 Gene