Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCNG1 Gene

protein-coding GIFtS: 60
GCID: GC05P162864

cyclin G1

(Previous symbol: CCNG)

Explore 54 diseases affiliated with
CCNG1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin G1¹ ²
CCNG¹ ² ³
Cyclin-G³
Cyclin-G1¹
CYCG1³
Cyclin-G³

External Ids:	HGNC: 1592¹	Entrez Gene: 900²	Ensembl: ENSG00000113328⁷	OMIM: 601578⁵	UniProtKB: P51959³

Export aliases for CCNG1 gene to outside databases

Previous GC identifers: GC05P163067 GC05P163457 GC05P162800 GC05P162845 GC05P162797 GC05P157964

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNG1:

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by

cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin

box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members.

Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same

protein have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCNG1_HUMAN, P51959

Function: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be

an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity)

Gene Wiki entry for CCNG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNG1 gene promoter:
Oct-B1 POU2F1 oct-B3 POU2F1a c-Myb Lmo2 STAT3 CUTL1 POU2F2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNG1 promoter sequence

Search SABiosciences Chromatin IP Primers for CCNG1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNG1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32-q34 Ensembl cytogenetic band: 5q34 HGNC cytogenetic band: 5q32-q34

CCNG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNG1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P162864: view genomic region (about GC identifiers)

Start:	162,864,575 bp from pter	End:	162,873,157 bp from pter
Size:	8,583 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCNG1_HUMAN, P51959 (See protein sequence)

Recommended Name: Cyclin-G1

Size: 295 amino acids; 34074 Da

Subcellular location: Nucleus. Note=DNA replication foci after DNA damage

Developmental stage: Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and

stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the

cell cycle

Sequence caution: Sequence=AAB03903.1; Type=Erroneous initiation; Sequence=CAA54821.1; Type=Erroneous initiation;

Secondary accessions: B2R7B2 D3DQK7 Q15757 Q96L32

Explore the universe of human proteins at neXtProt for CCNG1: NX_P51959

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51959

CCNG1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004051.1 NP_954854.1

ENSEMBL proteins:

ENSP00000424315 ENSP00000344635 ENSP00000424141 ENSP00000423791 ENSP00000421132

ENSP00000422379 ENSP00000427086 ENSP00000377506

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CCNG1 OriGene Custom Protein Services for CCNG1
	GenScript Custom Purified and Recombinant Proteins Services for CCNG1
	Novus Biologicals CCNG1 Proteins Novus Biologicals CCNG1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCNG1
	Uscn Proteins for CCNG1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0030425	dendrite	IEA	--
GO:0043025	neuronal cell body	IEA	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

CCNG1 for ontologies About GeneDecksing

CCNG1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CCNG1
	GenScript Custom Superior Antibodies Services for CCNG1
	Novus Biologicals CCNG1 Antibodies
	Search for Antibodies for CCNG1 at Abcam
	Uscn Antibodies for CCNG1
	ThermoFisher Antibodies for CCNG1

Assay Products for CCNG1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCNG1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCNG1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCNG1 for domains About GeneDecksing

2 InterPro domains/families:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

Graphical View of Domain Structure for InterPro Entry P51959

ProtoNet protein and cluster: P51959

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNG1_HUMAN, P51959

Similarity: Belongs to the cyclin family. Cyclin G subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCNG1_HUMAN, P51959

Function: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be

an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity)

Induction: Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage

Genatlas biochemistry entry for CCNG1:

cyclin G,modulator of the cell cycle and apoptosis,transcriptional target of p53 tumor suppressor gene

miRNA Products:		miRTarBase miRNAs that target CCNG1: hsa-mir-122 (MIRT003006)

		OriGene 3'-UTR Clone (see all 2): CCNG1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNG1
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNG1 (see all 38):
		hsa-miR-2052 hsa-miR-4307 hsa-miR-513a-5p hsa-miR-128 hsa-miR-605 hsa-miR-488 hsa-miR-3171 hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: CCNG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNG1 (see all 7) OriGene shRNA RFP: CCNG1 OriGene siRNA: CCNG1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNG1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCNG1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNG1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNG1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CCNG1 (NM_004060)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNG1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNG1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCNG1
		Search LifeMap BioReagents cell lines for CCNG1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNG1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0019904	protein domain specific binding	IEA	--

CCNG1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CCNG1: Ccng1^tm1Noj Ccng1^tm1Sst
     5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccng1):

cellular

digestive/alimentary

liver/biliary system

mortality/aging

tumorigenesis

CCNG1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

GPCR Pathway

Breast Cancer Regulation by Stathmin1

0.58

Pancreatic Adenocarcinoma

0.55

GADD45 Pathway

GADD45 Pathway

1.00

p53 pathway

p53 pathway

1.00

Direct p53 effectors

Direct p53 effectors

1.00

p53 signaling pathway

p53 signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNG1

	Breast Cancer Regulation by Stathmin1
	GADD45 Pathway
	Pancreatic Adenocarcinoma

2 BioSystems Pathways for CCNG1

	Direct p53 effectors
	p53 pathway

1 Kegg Pathway (Kegg details for CCNG1):

p53 signaling pathway

CCNG1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNG1

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/18 Interacting proteins for CCNG1 (P51959^{1, 2, 3} ENSP00000344635⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP2R1A	P30153²^,³, ENSP00000324804⁴	MINT-4299123 I2D: score=1 STRING: ENSP00000324804
TNIP1	Q15025¹^,³, ENSP00000317891⁴	EBI-3905829,EBI-357849 I2D: score=1 STRING: ENSP00000317891
TP53	P04637³, ENSP00000269305⁴	I2D: score=4 STRING: ENSP00000269305
GAK	O14976³, ENSP00000314499⁴	I2D: score=3 STRING: ENSP00000314499
MDM2	Q00987³, ENSP00000417281⁴	I2D: score=3 STRING: ENSP00000417281

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	8626390
GO:0006949	syncytium formation	IEA	--
GO:0007067	mitosis	IEA	--
GO:0007095	mitotic cell cycle G2/M transition DNA damage checkpoint	IEA	--
GO:0007420	brain development	IEA	--

CCNG1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCNG1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCNG1
10/16 Novoseek chemical compound relationships for CCNG1 gene (see all 16) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mimosine	43.9	1	10530763 (1)
retinoid	11	1	11795432 (1)
rapamycin	9.68	1	8268127 (1)
calcium	2.06	1	7954463 (1)
glucose	1.49	1	7954463 (1)
estrogen	0.945	1	11109161 (1)
steroid	0	2	7981461 (1)
threonine	0	3	18981217 (1)
tyrosine	0	2	9164677 (1), 12393265 (1)
actinomycin d	0	2	8806701 (1)

Search CenterWatch for drugs/clinical trials and news about CCNG1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCNG1 gene (2 alternative transcripts):

NM_004060.3 NM_199246.1

Unigene Cluster for CCNG1:

Cyclin G1

Hs.79101 [show with all ESTs]

Unigene Representative Sequence: NM_004060

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000512163 ENST00000506186 ENST00000340828(uc011dek.1 uc003lzb.3 uc011del.2 uc003lzc.3)

ENST00000511683 ENST00000510097 ENST00000511490 ENST00000510664 ENST00000512532

ENST00000504553 ENST00000514367 ENST00000509143 ENST00000509425 ENST00000393929

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CCNG1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNG1
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNG1 (see all 38):
		hsa-miR-2052 hsa-miR-4307 hsa-miR-513a-5p hsa-miR-128 hsa-miR-605 hsa-miR-488 hsa-miR-3171 hsa-miR-548m

		SwitchGear 3'UTR luciferase reporter plasmid: CCNG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNG1 (see all 7) OriGene shRNA RFP: CCNG1 OriGene siRNA: CCNG1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNG1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNG1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNG1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CCNG1 (NM_004060)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNG1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNG1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNG1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCNG1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNG1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNG1

Additional cDNA sequence:

AK297190.1 AK312913.1 AK316234.1 BC000196.1 BC007093.2 BT007134.1 D78341.1 L49504.1

U47413.1 U53328.1 X77794.1

22 DOTS entries:

DT.91760551 DT.100710854 DT.95358160 DT.95335621 DT.100816761 DT.100662820 DT.100816772 DT.120888767

DT.100718516 DT.120888753 DT.102820239 DT.120888779 DT.100816762 DT.100816768 DT.120888731 DT.120888732

DT.121364974 DT.75162503 DT.91683075 DT.91760553 DT.92022397 DT.120888745

24/507 AceView cDNA sequences (see all 507):

AA909702 BG575739 AI244199 AU280653 AW511801 AA631881 AI423572 BM453030

BE222141 C01233 BM970731 AI912285 AU120011 BE890159 AW058380 AI201352

BU634478 BM667421 AI264948 BC000196 BE504586 AA639763 AI056719 AA226926

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCNG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTATGGGT

About this image

CCNG1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCNG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNG1

SOURCE GeneReport for Unigene cluster: Hs.79101

UniProtKB/Swiss-Prot: CCNG1_HUMAN, P51959

Tissue specificity: High levels in skeletal muscle, ovary, kidney and colon

SABiosciences Expression via Pathway-Focused PCR Arrays including CCNG1:

Nephrotoxicity in human mouse rat

Cell Cycle in human mouse rat

p53 Signaling Pathway in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Hepatotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNG1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCNG1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNG1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNG1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNG1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CCNG1 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccng1^{1 , 5}	cyclin G1^{1, 5}	89.65(n)¹ 92.83(a)¹		11 (24.42 cM)⁵ 12450¹ NM_009831.2¹ NP_033961.1¹ 40748552⁵
chicken (Gallus gallus)	Aves	CCNG1¹	cyclin G1	76.03(n) 84.93(a)		416161 XM_003642047.1 XP_003642095.1
lizard (Anolis carolinensis)	Reptilia	CCNG1⁶	--	77(a)	1 ↔ 1	1(108058334-108063315)
African clawed frog (Xenopus laevis)	Amphibia	MGC53060²	similar to cyclin G1	74.12(n)		BC049393.1
zebrafish (Danio rerio)	Actinopterygii	ccng1²	cyclin G1	72.42(n)		171473 AY423016.1
fruit fly (Drosophila melanogaster)	Insecta	CycG⁶	Cyclin G	15(a)	1 → many	3R(27422364-27438386)

ENSEMBL Gene Tree for CCNG1 (if available)
TreeFam Gene Tree for CCNG1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCNG1 gene

CCNI2² CCNG2² CCNI²

3 SIMAP similar genes for CCNG1 using alignment to 6 protein entries: CCNG1_HUMAN (see all proteins):

DKFZp686M0576 CCNG2 CCNI

CCNG1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CCNG1
PGOHUM00000243779

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114917541^1,2	F,	--	162862603(+)	`CTTCTC/TATTGT`	2	--	us2k¹		1		WA	118
rs138118986^1,2		--	162862702(+)	`TTCTAA/CAGTCT`	2	--	us2k¹		0	--	--	--	--
rs17880718^1,2	C,	--	162862754(+)	`GGGTAC/TCAGTC`	2	--	us2k¹		3		NS NA WA	284
rs299325^1,2	C,F,A,H,	--	162862817(+)	`TATTCG/ATGCTT`	2	--	us2k¹		15		NS EA NA WA CSA	806
rs10071964^1,2	C,F,	--	162862903(+)	`ATCTCG/AGCTCA`	2	--	us2k¹		5		NA NS WA CSA	172
rs299324^1,2	C,F,A,	--	162863009(+)	`ttgtaT/Ctttca`	2	--	us2k¹		7		NS NA WA	178
rs17884570^1,2	C,F,	--	162863023(+)	`GAGACG/AGGGTT`	2	--	us2k¹		1		NS	166
rs192618194^1,2		--	162863109(+)	`GATTAC/TAGGTG`	2	--	us2k¹		0	--	--	--	--
rs17884119^1,2	C,F,	--	162863132(+)	`CCCAGC/GCTGCC`	2	--	us2k¹		1		NS	166
rs17881976^1,2	C,F,	--	162863171(+)	`TTTTTT/AAAAAA`	2	--	us2k¹		1		NS	166

HapMap Linkage Disequilibrium report for CCNG1 (162864575 - 162873157 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCNG1
1 CNV: 93332

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNG1

DNA2.0 Custom Variant and Variant Library Synthesis for CCNG1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCNG1 for disorders           About GeneDecksing

OMIM gene information: 601578    OMIM disorders: --

20/54 diseases for CCNG1 (see all 54):    About MalaCards

cervical intraepithelial neoplasia actinic keratosis non-hodgkin lymphoma soft tissue sarcoma

burkitt's lymphoma leukemia/lymphoma b-cell lymphomas laryngeal squamous cell carcinoma

mantle cell lymphoma leukemia/lymphoma, t-cell squamous cell carcinoma benign tumors

hodgkin's lymphoma keratosis transitional cell carcinoma chronic lymphocytic leukemia

ovarian cancer colonic polyps epithelial ovarian cancer lymphocytic leukemia

10/34 Novoseek disease relationships for CCNG1 gene (see all 34) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	79.5	21	7797074 (1), 10477583 (1), 8594075 (1), 8943373 (1) (see all 20)
lymphoma mantle-cell	48.6	1	9209645 (1)
tumors	41.3	38	8954786 (2), 12634633 (2), 12556559 (2), 10196184 (2) (see all 29)
cancer	37	15	11496300 (1), 12895470 (1), 17616664 (1), 20384524 (1) (see all 15)
osteosarcoma	30.9	7	7585620 (2), 19532136 (1), 9852531 (1), 10194136 (1) (see all 5)
lymphoma	29.3	12	11291051 (3), 11035575 (1), 19757306 (1), 9499444 (1) (see all 7)
breast cancer	21.9	6	9178893 (1), 8614416 (1), 9194584 (1), 9671407 (1) (see all 6)
carcinoma squamous cell	20.7	2	9813719 (1), 11115554 (1)
neoplastic transformation	18.1	1	9579467 (1)
burkitt lymphoma	15.9	1	8626390 (1)

Human Genome Epidemiology (HuGE) Navigator: CCNG1 (1 document)

Export disorders for CCNG1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCNG1 gene, integrated from 9 sources (see all 255):
(articles sorted by number of sources associating them with CCNG1)

Utopia: connect your pdf to the dynamic
world of online information

Structure and chromosomal assignment of the human cyclin G gene. (PubMed id 8954786)^{1, 2, 3, 9} Endo Y.... Nojima H. (1996)
Characterisation of human cyclin G1 and G2: DNA damage inducible genes. (PubMed id 8806701)^{1, 2, 3, 9} Bates S.A.... Vousden K.H. (1996)
Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. (PubMed id 8626390)^{1, 2, 9} Horne M.C....Wahl A.F. (1996)
Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. (PubMed id 10196184)^{1, 2, 9} Reimer C.L.... Lee S.W. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1. (PubMed id 16322753)^{1, 9} Seo H.R....Lee Y.S. (2006)
Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation. (PubMed id 12642871)^{1, 9} Ohtsuka T....Lee S.W. (2003)
The negative role of cyclin G in ATM-dependent p53 activation. (PubMed id 15077171)^{1, 9} Ohtsuka T....Lee S.W. (2004)
Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways. (PubMed id 12556559)^{1, 9} Zhao L....Quelle D.E. (2003)
Increased expression of cyclin G1 in leiomyoma compared with normal myometrium. (PubMed id 12634633)^{1, 9} Baek W.K....Cho C.H. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 900	HGNC: 1592	AceView: CCNG1	Ensembl:ENSG00000113328	euGenes: HUgn900
ECgene: CCNG1	Kegg: 900	H-InvDB: CCNG1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCNG1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCNG1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccng1/

Intellectual Property for CCNG1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCNG1 gene:
Search GeneIP for patents involving CCNG1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CCNG1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNG1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNG1
	OriGene Protein Over-expression Lysate for CCNG1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CCNG1		OriGene 3'-UTR Clone for CCNG1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNG1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNG1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CCNG1		OriGene Custom Protein Services for CCNG1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCNG1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNG1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNG1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNG1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNG1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNG1

	GenScript Custom Purified and Recombinant Proteins Services for CCNG1		GenScript cDNA clones with any tag delivered in your preferred vector for CCNG1
	GenScript Custom Assay Services for CCNG1		GenScript Custom Superior Antibodies Services for CCNG1
	GenScript Custom overexpressing Cell Line Services for CCNG1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CCNG1 promoter
	Search Chromatin IP Primers for CCNG1
	RT² qPCR Primer Assay in human, mouse, rat CCNG1
	GNC Network for CCNG1
	SABiosciences PCR Arrays including human, mouse, rat CCNG1

Search Tocris compounds for CCNG1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CCNG1 antibodies
	CCNG1 proteins
	CCNG1 lysates

	Search for Antibodies for CCNG1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CCNG1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CCNG1

CCNG1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CCNG1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNG1

	SwitchGear 3'UTR luciferase reporter plasmids for CCNG1
	SwitchGear Promoter luciferase reporter plasmids for CCNG1

ThermoFisher Antibodies for CCNG1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNG1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CCNG1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CCNG1 Gene

cyclin G1

Aliases
for CCNG1 gene

Summaries
for CCNG1 gene

Genomic Views
for CCNG1 gene

Proteins
for CCNG1 gene

Protein Domains /
Families
for CCNG1 gene

Function
for CCNG1 gene

Pathways & Interactions
for CCNG1 gene

Drugs & Compounds
for CCNG1 gene

Transcripts
for CCNG1 gene

Expression
for CCNG1 gene

Orthologs
for CCNG1 gene

Paralogs
for CCNG1 gene

Genomic Variants
for CCNG1 gene

Disorders / Diseases
for CCNG1 gene

Publications
for CCNG1 gene

External Searches for CCNG1 gene

Genome Databases showing CCNG1 gene

Other Databases showing CCNG1 gene

Specialized Databases showing CCNG1 gene

Intellectual Property
for CCNG1 gene

Products
for CCNG1 gene

View Random Gene

Gastric Cancer
BREAST CARCINOMA
Melanoma
Retinoblastoma
dysplasia
Lymphoma Mantle-Cell
Hodgkin Disease
Carcinoma
Leukemia
Osteosarcoma
Breast Cancer
NSCLC
HEPATOCELLULAR CARCINOMA
Adenocarcinoma
Cancer
Pancreatic Cancer
Cancer Lung
Cervical Intraepithelial Neoplasia
Lymphoma
GASTRIC CARCINOMA
Ovarian Cancer
Adenoma
Colorectal Cancer
Burkitt Lymphoma
benign tumor
Carcinoma Squamous Cell
Colorectal Tumors
prostate cancer
Tumors
Metastasis
Sarcoma
Lymphoma Non-Hodgkins
neoplastic transformation
Papilloma

Advanced Search

Export list of displayed genes

CCNG1 Gene

cyclin G1

Aliasesfor CCNG1 gene

Summariesfor CCNG1 gene

Genomic Viewsfor CCNG1 gene

Proteinsfor CCNG1 gene

Protein Domains /Familiesfor CCNG1 gene

Functionfor CCNG1 gene

Pathways & Interactionsfor CCNG1 gene

Drugs & Compoundsfor CCNG1 gene

Transcriptsfor CCNG1 gene

Expression for CCNG1 gene

Orthologsfor CCNG1 gene

Paralogsfor CCNG1 gene

Genomic Variantsfor CCNG1 gene

Disorders / Diseasesfor CCNG1 gene

Publicationsfor CCNG1 gene

External Searches for CCNG1 gene

Genome Databases showing CCNG1 gene

Other Databases showing CCNG1 gene

Specialized Databases showing CCNG1 gene

Intellectual Propertyfor CCNG1 gene

Productsfor CCNG1 gene

View Random Gene

Aliases
for CCNG1 gene

Summaries
for CCNG1 gene

Genomic Views
for CCNG1 gene

Proteins
for CCNG1 gene

Protein Domains /
Families
for CCNG1 gene

Function
for CCNG1 gene

Pathways & Interactions
for CCNG1 gene

Drugs & Compounds
for CCNG1 gene

Transcripts
for CCNG1 gene

Expression
for CCNG1 gene

Orthologs
for CCNG1 gene

Paralogs
for CCNG1 gene

Genomic Variants
for CCNG1 gene

Disorders / Diseases
for CCNG1 gene

Publications
for CCNG1 gene

Intellectual Property
for CCNG1 gene

Products
for CCNG1 gene