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Aliases for CCNF Gene

Aliases for CCNF Gene

  • Cyclin F 2 3
  • FBX1 3 4 6
  • F-Box Only Protein 1 3 4
  • FBXO1 3 4
  • G2/Mitotic-Specific Cyclin-F 3
  • Cyclin-F 3

External Ids for CCNF Gene

Summaries for CCNF Gene

Entrez Gene Summary for CCNF Gene

  • This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNF Gene

CCNF (Cyclin F) is a Protein Coding gene. Diseases associated with CCNF include necrotizing fasciitis. Among its related pathways are GPCR Pathway and GADD45 Pathway.

UniProtKB/Swiss-Prot for CCNF Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.

Gene Wiki entry for CCNF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNF Gene

Genomics for CCNF Gene

Genomic Location for CCNF Gene

Start:
2,429,394 bp from pter
End:
2,458,858 bp from pter
Size:
29,465 bases
Orientation:
Plus strand

Genomic View for CCNF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNF Gene

Regulatory Elements for CCNF Gene

Proteins for CCNF Gene

  • Protein details for CCNF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41002-CCNF_HUMAN
    Recommended name:
    Cyclin-F
    Protein Accession:
    P41002
    Secondary Accessions:
    • B2R8H3
    • Q96EG9

    Protein attributes for CCNF Gene

    Size:
    786 amino acids
    Molecular mass:
    87640 Da
    Quaternary structure:
    • Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway.
    Miscellaneous:
    • Founding member of the F-box domain protein family, which obtained its name from cyclin-F.

neXtProt entry for CCNF Gene

Proteomics data for CCNF Gene at MOPED

Post-translational modifications for CCNF Gene

  • Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence
  • Phosphorylated just before cells enter into mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNF Gene

Domains for CCNF Gene

Gene Families for CCNF Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for CCNF Gene

UniProtKB/Swiss-Prot:

CCNF_HUMAN
Domain:
  • The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.:
    • P41002
  • Contains 1 cyclin N-terminal domain.:
    • P41002
  • Contains 1 F-box domain.:
    • P41002
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.:
    • P41002
genes like me logo Genes that share domains with CCNF: view

Function for CCNF Gene

Molecular function for CCNF Gene

GENATLAS Biochemistry: cyclin F,involved in the regulation of cell cycle
UniProtKB/Swiss-Prot Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.

Gene Ontology (GO) - Molecular Function for CCNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20596027
genes like me logo Genes that share ontologies with CCNF: view
genes like me logo Genes that share phenotypes with CCNF: view

Animal Models for CCNF Gene

MGI Knock Outs for CCNF:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCNF Gene

Localization for CCNF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNF Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNF Gene COMPARTMENTS Subcellular localization image for CCNF gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20596027
GO:0005814 centriole IDA 20596027
GO:0019005 SCF ubiquitin ligase complex IDA 20596027
genes like me logo Genes that share ontologies with CCNF: view

Pathways for CCNF Gene

SuperPathways for CCNF Gene

Superpath Contained pathways
1 GPCR Pathway
2 GADD45 Pathway
genes like me logo Genes that share pathways with CCNF: view

Pathways by source for CCNF Gene

2 Qiagen pathways for CCNF Gene

Gene Ontology (GO) - Biological Process for CCNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000320 re-entry into mitotic cell cycle IEA --
GO:0001890 placenta development IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0010826 negative regulation of centrosome duplication IDA 20596027
GO:0016567 protein ubiquitination IDA 20596027
genes like me logo Genes that share ontologies with CCNF: view

Transcripts for CCNF Gene

Unigene Clusters for CCNF Gene

Cyclin F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5:

Relevant External Links for CCNF Gene

GeneLoc Exon Structure for
CCNF
ECgene alternative splicing isoforms for
CCNF

Expression for CCNF Gene

mRNA expression in normal human tissues for CCNF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCNF Gene

SOURCE GeneReport for Unigene cluster for CCNF Gene Hs.1973

mRNA Expression by UniProt/SwissProt for CCNF Gene

P41002-CCNF_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with CCNF: view

Orthologs for CCNF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCNF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNF 36
  • 99.45 (n)
  • 99.87 (a)
CCNF 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNF 36
  • 84.93 (n)
  • 87.01 (a)
CCNF 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNF 36
  • 86.3 (n)
  • 87.5 (a)
CCNF 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnf 36
  • 83.42 (n)
  • 84.54 (a)
Ccnf 16
Ccnf 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNF 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNF 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnf 36
  • 84.06 (n)
  • 85.51 (a)
chicken
(Gallus gallus)
Aves CCNF 36
  • 70.14 (n)
  • 69.23 (a)
CCNF 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69175 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnf 36
  • 64.23 (n)
  • 65 (a)
Str.10283 36
zebrafish
(Danio rerio)
Actinopterygii ccnf 36
  • 62.41 (n)
  • 57.82 (a)
ccnf 37
  • 53 (a)
OneToOne
Species with no ortholog for CCNF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNF Gene

ENSEMBL:
Gene Tree for CCNF (if available)
TreeFam:
Gene Tree for CCNF (if available)

Paralogs for CCNF Gene

No data available for Paralogs for CCNF Gene

Variants for CCNF Gene

Sequence variations from dbSNP and Humsavar for CCNF Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1136062 -- 2,452,640(-) ATGTC(A/G)TCAAT intron-variant
rs1802723 -- 2,457,683(+) ATGTG(A/T)ACACC utr-variant-3-prime
rs3810795 -- 2,457,928(-) ACAGA(A/G)GACTT utr-variant-3-prime
rs4305017 -- 2,435,191(+) gcttg(C/T)agtga intron-variant
rs4306510 -- 2,434,950(+) TTTGA(C/T)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNF Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2545n71 CNV Loss 21882294
nsv905139 CNV Loss 21882294
nsv833121 CNV Loss 17160897
dgv2569n71 CNV Loss 21882294
dgv2570n71 CNV Loss 21882294
nsv905149 CNV Loss 21882294
nsv905152 CNV Loss 21882294
nsv905153 CNV Loss 21882294
nsv827513 CNV Gain 20364138

Relevant External Links for CCNF Gene

HapMap Linkage Disequilibrium report
CCNF

Disorders for CCNF Gene

(1) MalaCards Diseases for CCNF Gene

Search for CCNF Gene in MalaCards »

(1) University of Copenhagen DISEASES for CCNF Gene

(1) Novoseek inferred disease relationships for CCNF Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
genes like me logo Genes that share disorders with CCNF: view

No data available for UniProtKB/Swiss-Prot for CCNF Gene

Publications for CCNF Gene

  1. A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). (PMID: 7896286) Kraus B. … Frischauf A.-M. (Genomics 1994) 2 3 4 23
  2. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. (PMID: 8706131) Bai C. … Elledge S.J. (Cell 1996) 3 4 23
  3. Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. (PMID: 12122006) Fung T.K. … Poon R.Y. (J. Biol. Chem. 2002) 3 4 23
  4. Human cyclin F. (PMID: 7813445) Bai C. … Elledge S.J. (EMBO J. 1994) 3 4 23
  5. Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. (PMID: 10716937) Kong M. … Donoghue D.J. (EMBO J. 2000) 3 4

Products for CCNF Gene

  • Addgene plasmids for CCNF

Sources for CCNF Gene

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