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Aliases for CCNF Gene

Aliases for CCNF Gene

  • Cyclin F 2 3 5
  • F-Box Only Protein 1 3 4
  • FBXO1 3 4
  • FBX1 3 4
  • G2/Mitotic-Specific Cyclin-F 3

External Ids for CCNF Gene

Previous GeneCards Identifiers for CCNF Gene

  • GC16P002273
  • GC16P002504
  • GC16P002419
  • GC16P002405
  • GC16P002479

Summaries for CCNF Gene

Entrez Gene Summary for CCNF Gene

  • This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNF Gene

CCNF (Cyclin F) is a Protein Coding gene. Among its related pathways are GPCR Pathway and GADD45 Pathway.

UniProtKB/Swiss-Prot for CCNF Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.

Gene Wiki entry for CCNF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNF Gene

Genomics for CCNF Gene

Regulatory Elements for CCNF Gene

Promoters for CCNF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNF on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNF Gene

Chromosome:
16
Start:
2,429,394 bp from pter
End:
2,458,858 bp from pter
Size:
29,465 bases
Orientation:
Plus strand

Genomic View for CCNF Gene

Genes around CCNF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNF Gene

Proteins for CCNF Gene

  • Protein details for CCNF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41002-CCNF_HUMAN
    Recommended name:
    Cyclin-F
    Protein Accession:
    P41002
    Secondary Accessions:
    • B2R8H3
    • Q96EG9

    Protein attributes for CCNF Gene

    Size:
    786 amino acids
    Molecular mass:
    87640 Da
    Quaternary structure:
    • Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway.
    Miscellaneous:
    • Founding member of the F-box domain protein family, which obtained its name from cyclin-F.

neXtProt entry for CCNF Gene

Proteomics data for CCNF Gene at MOPED

Post-translational modifications for CCNF Gene

  • Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence.
  • Phosphorylated just before cells enter into mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNF Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCNF (CCNF)

No data available for DME Specific Peptides for CCNF Gene

Domains & Families for CCNF Gene

Gene Families for CCNF Gene

Protein Domains for CCNF Gene

Suggested Antigen Peptide Sequences for CCNF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41002

UniProtKB/Swiss-Prot:

CCNF_HUMAN :
  • The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.
  • Belongs to the cyclin family. Cyclin AB subfamily.
Domain:
  • The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.
  • Contains 1 cyclin N-terminal domain.
  • Contains 1 F-box domain.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNF: view

Function for CCNF Gene

Molecular function for CCNF Gene

GENATLAS Biochemistry:
cyclin F,involved in the regulation of cell cycle
UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
genes like me logo Genes that share phenotypes with CCNF: view

Animal Models for CCNF Gene

MGI Knock Outs for CCNF:

Animal Model Products

miRNA for CCNF Gene

miRTarBase miRNAs that target CCNF

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNF Gene

Localization for CCNF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNF Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNF Gene COMPARTMENTS Subcellular localization image for CCNF gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IDA 20596027
genes like me logo Genes that share ontologies with CCNF: view

Pathways & Interactions for CCNF Gene

SuperPathways for CCNF Gene

Superpath Contained pathways
1 GPCR Pathway
2 GADD45 Pathway
genes like me logo Genes that share pathways with CCNF: view

Pathways by source for CCNF Gene

1 GeneTex pathway for CCNF Gene
2 Qiagen pathways for CCNF Gene

Gene Ontology (GO) - Biological Process for CCNF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0010826 negative regulation of centrosome duplication IEA,IDA 20596027
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 20596027
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CCNF: view

No data available for SIGNOR curated interactions for CCNF Gene

Drugs & Compounds for CCNF Gene

No Compound Related Data Available

Transcripts for CCNF Gene

Unigene Clusters for CCNF Gene

Cyclin F:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5:

Relevant External Links for CCNF Gene

GeneLoc Exon Structure for
CCNF
ECgene alternative splicing isoforms for
CCNF

Expression for CCNF Gene

mRNA expression in normal human tissues for CCNF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNF Gene



SOURCE GeneReport for Unigene cluster for CCNF Gene Hs.1973

mRNA Expression by UniProt/SwissProt for CCNF Gene

P41002-CCNF_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CCNF: view

Protein tissue co-expression partners for CCNF Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCNF Gene

Orthologs for CCNF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCNF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNF 35
  • 84.93 (n)
  • 87.01 (a)
CCNF 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNF 35
  • 86.3 (n)
  • 87.5 (a)
CCNF 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnf 35
  • 83.42 (n)
  • 84.54 (a)
Ccnf 16
Ccnf 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNF 35
  • 99.45 (n)
  • 99.87 (a)
CCNF 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnf 35
  • 84.06 (n)
  • 85.51 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNF 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNF 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNF 35
  • 70.14 (n)
  • 69.23 (a)
CCNF 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnf 35
  • 64.23 (n)
  • 65 (a)
Str.10283 35
African clawed frog
(Xenopus laevis)
Amphibia MGC69175 35
zebrafish
(Danio rerio)
Actinopterygii ccnf 35
  • 62.41 (n)
  • 57.82 (a)
ccnf 36
  • 53 (a)
OneToOne
Species with no ortholog for CCNF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNF Gene

ENSEMBL:
Gene Tree for CCNF (if available)
TreeFam:
Gene Tree for CCNF (if available)

Paralogs for CCNF Gene

No data available for Paralogs for CCNF Gene

Variants for CCNF Gene

Sequence variations from dbSNP and Humsavar for CCNF Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4387603 -- 2,436,614(+) TCCTA(C/T)CCCTA intron-variant
rs4494541 -- 2,435,067(+) taaca(C/T)ggtga intron-variant
rs4412969 -- 2,428,252(+) CTGTT(C/T)ACTCT upstream-variant-2KB
rs4305017 -- 2,435,191(+) gcttg(C/T)agtga intron-variant
rs4306510 -- 2,434,950(+) TTTGA(C/T)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNF Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2545n71 CNV Loss 21882294
nsv905139 CNV Loss 21882294
nsv833121 CNV Loss 17160897
dgv2569n71 CNV Loss 21882294
dgv2570n71 CNV Loss 21882294
nsv905149 CNV Loss 21882294
nsv905152 CNV Loss 21882294
nsv905153 CNV Loss 21882294
nsv827513 CNV Gain 20364138

Variation tolerance for CCNF Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNF Gene

HapMap Linkage Disequilibrium report
CCNF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNF Gene

Disorders for CCNF Gene

Relevant External Links for CCNF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNF

No disorders were found for CCNF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNF Gene

Publications for CCNF Gene

  1. A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). (PMID: 7896286) Kraus B. … Frischauf A.-M. (Genomics 1994) 2 3 4 23 67
  2. Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. (PMID: 12122006) Fung T.K. … Poon R.Y. (J. Biol. Chem. 2002) 3 23
  3. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. (PMID: 8706131) Bai C. … Elledge S.J. (Cell 1996) 3 23
  4. Human cyclin F. (PMID: 7813445) Bai C. … Elledge S.J. (EMBO J. 1994) 3 23
  5. A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis. (PMID: 23182110) D'Angiolella V. … Pagano M. (Trends Cell Biol. 2013) 3

Products for CCNF Gene

Sources for CCNF Gene

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