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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNF Gene

protein-coding   GIFtS: 56
GCID: GC16P002479

cyclin F
 Explore 8 diseases affiliated with
CCNF via
MalaCards
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 Human Malady Compendium 
Biological research products
for CCNF    

Aliases
for CCNF gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin F1 2
FBX11 2 3 5
FBXO11 2 3
F-Box Only Protein 12 3
Cyclin-F1
G2/Mitotic-Specific Cyclin-F2

External Ids:    HGNC: 15911   Entrez Gene: 8992   Ensembl: ENSG000001620637   OMIM: 6002275   UniProtKB: P410023   

Export aliases for CCNF gene to outside databases

Previous GC identifers: GC16P002273 GC16P002504 GC16P002419 GC16P002405


Summaries
for CCNF gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCNF:
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through
their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein
family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of
the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in
phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40
domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction
modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the
first proteins in which the F-box motif was identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCNF_HUMAN, P41002
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an
inhibitor of centrosome reduplication

Gene Wiki entry for CCNF


Genomic Views
for CCNF gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNF gene promoter:
         AhR   p300   LCR-F1   C/EBPalpha   E47   Egr-2   POU2F1   POU2F1a   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNF promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CCNF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNF gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002479:  view genomic region     (about GC identifiers)

Start:
 2,479,395 bp from pter      End:
 2,508,859 bp from pter
Size:
 29,465 bases      Orientation:
 plus strand

Proteins
for CCNF gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCNF_HUMAN, P41002 (See protein sequence)
Recommended Name: Cyclin-F  
Size: 786 amino acids; 87640 Da
Subunit: Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1;
interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110
ubiquitination and degradation via the proteasome pathway
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, centrosome, centriole. Note=Localization in the centrosome is
rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to
centrosomes is not dependent on CP110. Also localizes to the nucleus
Developmental stage: Appears in S phase, peaks in G2 phase and disappears as cells enter into mitosis (at protein
level)
Miscellaneous: Founding member of the F-box domain protein family, which obtained its name from cyclin-F
(PubMed:8706131)
Secondary accessions: B2R8H3 Q96EG9

Explore the universe of human proteins at neXtProt for CCNF: NX_P41002

Post-translational modifications:

  • Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on
    • the proteasome or ubiquitin and depends on the C-terminal PEST sequence1
  • Phosphorylated just before cells enter into mitosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41002

    • CCNF Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001752.2  
    ENSEMBL proteins: 
     ENSP00000293968   ENSP00000380256   ENSP00000457587  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: CCNF
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    Novus Biologicals CCNF Protein
    Novus Biologicals CCNF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CCNF

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005814centriole IDA--
    GO:0019005SCF ubiquitin ligase complex IDA--


    CCNF for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CCNF

    Protein Domains /
    Families
    for CCNF gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCNF for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry P41002

    ProtoNet protein and cluster: P41002

    1 Blocks protein family: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNF_HUMAN, P41002
    Domain: The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1
    localization to the nucleus
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily
    Similarity: Contains 1 cyclin N-terminal domain
    Similarity: Contains 1 F-box domain


    Function
    for CCNF gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCNF_HUMAN, P41002
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
    mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an
    inhibitor of centrosome reduplication

         Genatlas biochemistry entry for CCNF:
    cyclin F,involved in the regulation of cell cycle

    miRNA
    Products:            		miRTarBase miRNAs that target CCNF:
    hsa-mir-424 (MIRT000653), hsa-mir-503 (MIRT000643), hsa-let-7b (MIRT005061)

    OriGene 3'-UTR Clone: CCNF
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNF
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNF (see all 17):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-500a hsa-let-7g hsa-miR-4314 hsa-let-7a hsa-miR-331-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CCNF 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNF (see all 7)
    OriGene shRNA RFP: CCNF
    OriGene siRNA: CCNF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNF

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCNF

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNF (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNF
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    GenScript: all cDNA clones in your preferred vector: CCNF (NM_001761)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNF 

    Cell Line
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    Search LifeMap BioReagents cell lines for CCNF

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNF

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    CCNF for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CCNF:
     Decreased number of cells in m 

    Animal Models:
         Mouse knock-out Ccnftm1.1Sje for CCNF
         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccnf):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     limbs/digits/tail  mortality/aging  nervous system  skeleton 

    CCNF for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCNF gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GADD45 Pathway
    		GADD45 Pathway1.00
    2GPCR Pathway
    		Pancreatic Adenocarcinoma0.55

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNF
        GADD45 Pathway
    Pancreatic Adenocarcinoma


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for CCNF (P410021, 2, 3 ENSP000003802564) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, ENSP000002314874EBI-1207574,EBI-307486 STRING: ENSP00000231487
    CCNB1P146353, ENSP000002564424I2D: score=5 STRING: ENSP00000256442
    RRM2P313501, ENSP000003029554EBI-1207574,EBI-2339245 STRING: ENSP00000302955
    CCP110O433032MINT-8397026 MINT-8396972
    CDK1P064933I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000320re-entry into mitotic cell cycle IEA--
    GO:0001890placenta development IEA--
    GO:0007067mitosis IEA--
    GO:0010826negative regulation of centrosome duplication IDA--
    GO:0016567protein ubiquitination IDA--


    CCNF for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCNF gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNF
    Search CenterWatch for drugs/clinical trials and news about CCNF 

    Transcripts
    for CCNF gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCNF gene: 
    NM_001761.2  

    Unigene Cluster for CCNF:

    Cyclin F
    Hs.1973  [show with all ESTs]
    Unigene Representative Sequence: NM_001761
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293968 ENST00000397066(uc002cqd.1 uc002cqe.1) ENST00000569093
    ENST00000564333 ENST00000564236

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CCNF
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNF
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNF (see all 17):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-500a hsa-let-7g hsa-miR-4314 hsa-let-7a hsa-miR-331-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CCNF 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNF (see all 7)
    OriGene shRNA RFP: CCNF
    OriGene siRNA: CCNF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNF
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNF (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNF
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCNF (NM_001761)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNF 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNF
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCNF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNF

    Additional cDNA sequence: 

    AB208829.1 AK172853.1 AK313371.1 BC012349.1 U17105.1 Z36714.1 

    5 DOTS entries:

    DT.312192  DT.97763304  DT.95161989  DT.97789764  DT.312193 

    24/95 AceView cDNA sequences (see all 95):

    BM559197 BM478195 BU164145 BQ215590 BX283093 BC012349 U17105 BM792099 
    BQ690469 BQ061685 AW402106 AW451030 AA996201 BQ949803 BP364905 BQ951762 
    BE467820 BX436486 BQ223292 BQ690697 AA598598 BM456066 BX452305 NM_001761 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                -                                                     -                                       
    SP2:                    -           -                                                     -                                       
    SP3:                    -           -                                                                                             
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CCNF

    Expression
    for CCNF gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGAGCCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CCNF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNF

    SOURCE GeneReport for Unigene cluster: Hs.1973

    UniProtKB/Swiss-Prot: CCNF_HUMAN, P41002
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCNF: 
              Cell Cycle in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNF
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNF

    Orthologs
    for CCNF gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNF gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCNF1 cyclin F 69.71(n)
    68.47(a)    		   416749  XM_415043.3  XP_415043.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC691752 hypothetical protein MGC69175 73.29(n)    BC056134.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ccnf1 cyclin F 60.77(n)
    55.68(a)    		   266981  NM_207048.1  NP_996931.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CYCA3;36
    CYCA3;16
    (see all 10)    		 cyclin A3-1
    (see all 10)    		 20(a)
    20(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 1(17303676-17305197)
    5(17293227-17294789)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 15)    		 cyclin, putative, expressed
    (see all 15)    		 5(a)
    18(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 2(23804423-23813955)
    3(22843972-22845834)


    ENSEMBL Gene Tree for CCNF (if available)
    TreeFam Gene Tree for CCNF (if available) 

    Paralogs
    for CCNF gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CCNF gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/618 NCBI SNPs in CCNF are shown (see all 618)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1148058581,2
    		C,--2477468(+) TCCCAT/CGCCCC 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1822546321,2
    		--2477690(+) CACACC/TCTGGA 1 -- us2k10--------
    rs1417471451,2
    		--2477935(+) CTCATA/GGCTGG 1 -- us2k10--------
    rs45786471,2
    		C,F,A,H,--2478187(+) GAATAG/TTCCCA 1 -- us2k111Minor allele frequency- T:0.24NA WA CSA EA 257
    rs1507603641,2
    		--2478202(+) CCAGAC/TCCTCT 1 -- us2k10--------
    rs44129691,2
    		C,F,A,H,--2478253(+) CTGTTC/TACTCT 1 -- us2k122Minor allele frequency- T:0.22NS EA NA WA CSA 2350
    rs794847871,2
    		C--2478297(+) CCAGGA/GCTCCT 1 -- us2k10--------
    rs66002061,2
    		C,F,A,H,--2478550(+) TGGGCT/ACTGCC 1 -- us2k114Minor allele frequency- A:0.19NA WA CSA EA 559
    rs344015521,2
    		C,--2478746(+) GACTTC/-CCAGC 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1873293641,2
    		--2478761(+) GCTCCA/GACCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNF (2479395 - 2508859 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CCNF
         2 CNVs: 4918 5329

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    Disorders / Diseases
    for CCNF gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCNF for disorders           About GeneDecksing

    OMIM gene information: 600227    OMIM disorders: --

    8 diseases for CCNF:    About MalaCards
    necrotizing fasciitis    fasciitis    polycystic kidney disease    kidney disease
    lung adenocarcinoma    adenocarcinoma    breast cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for CCNF:
    Necrotizing fasciitis

    1 Novoseek disease relationship for CCNF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12878869 (1)


    Export disorders for CCNF gene to outside databases

    Publications
    for CCNF gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNF gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with CCNF)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). (PubMed id 7896286)1, 2, 3, 9 Kraus B.... Frischauf A.-M. (1994)
    2. Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. (PubMed id 12122006)1, 2, 9 Fung T.K....Poon R.Y. (2002)
    3. Human cyclin F. (PubMed id 7813445)1, 2, 9 Bai C.... Elledge S.J. (1994)
    4. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. (PubMed id 8706131)1, 2, 9 Bai C....Elledge S.J. (1996)
    5. SCF(Cyclin F) controls centrosome homeostasis and mit otic fidelity through CP110 degradation. (PubMed id 20596027)1, 2 D'Angiolella V....Pagano M. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. (PubMed id 10716937)1, 2 Kong M....Donoghue D.J. (2000)
    8. A p27Kip1 mutant that does not inhibit CDK activity pr omotes centrosome amplification and micronucleation. (PubMed id 22158041)1 Sharma S.S....Pledger W.J. (2012)
    9. Cyclin F-mediated degradation of ribonucleotide reduct ase M2 controls genome integrity and DNA repair. (PubMed id 22632967)1 D'Angiolella V....Pagano M. (2012)
    10. Neurl4, a novel daughter centriole protein, prevents f ormation of ectopic microtubule organizing centres. (PubMed id 22441691)2 Li J....Dynlacht B.D. (2012)

    External Searches for CCNF gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCNF gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 899 HGNC: 1591 AceView: CCNF Ensembl:ENSG00000162063 euGenes: HUgn899
    ECgene: CCNF H-InvDB: CCNF

    Other Databases showing CCNF gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCNF gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNF Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CCNF gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCNF gene:
    Search GeneIP for patents involving CCNF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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