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CCNF Gene

protein-coding   GIFtS: 56
GCID: GC16P002479

Cyclin F

  See CCNF-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin F1 2
FBX12 3 5
FBXO12 3
F-Box Only Protein 12 3
cyclin-F2
G2/Mitotic-Specific Cyclin-F2

External Ids:    HGNC: 15911   Entrez Gene: 8992   Ensembl: ENSG000001620637   OMIM: 6002275   UniProtKB: P410023   

Export aliases for CCNF gene to outside databases

Previous GC identifers: GC16P002273 GC16P002504 GC16P002419 GC16P002405


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNF Gene:
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions
through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the
F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box
proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided
into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either
different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs
to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CCNF Gene:
CCNF (cyclin F) is a protein-coding gene. Diseases associated with CCNF include necrotizing fasciitis.

UniProtKB/Swiss-Prot: CCNF_HUMAN, P41002
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting
as an inhibitor of centrosome reduplication

Gene Wiki entry for CCNF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNF gene promoter:
         AhR   p300   LCR-F1   C/EBPalpha   E47   Egr-2   POU2F1   POU2F1a   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNF promoter sequence
   Search Chromatin IP Primers for CCNF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CCNF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNF gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002479:  view genomic region     (about GC identifiers)

Start:
2,479,395 bp from pter      End:
2,508,859 bp from pter
Size:
29,465 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCNF_HUMAN, P41002 (See protein sequence)
Recommended Name: Cyclin-F  
Size: 786 amino acids; 87640 Da
Subunit: Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1;
interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to
CCP110 ubiquitination and degradation via the proteasome pathway
Developmental stage: Appears in S phase, peaks in G2 phase and disappears as cells enter into mitosis (at protein
level)
Miscellaneous: Founding member of the F-box domain protein family, which obtained its name from cyclin-F
(PubMed:8706131)
Secondary accessions: B2R8H3 Q96EG9

Explore the universe of human proteins at neXtProt for CCNF: NX_P41002

Explore proteomics data for CCNF at MOPED

Post-translational modifications: 

  • Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not
    dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence1
  • Phosphorylated just before cells enter into mitosis1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCNF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001752.2  
    ENSEMBL proteins: 
     ENSP00000293968   ENSP00000380256   ENSP00000457587  

    CCNF Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CCNF

     
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    antibodies-online proteins for CCNF (5 products) 

     
    antibodies-online peptides for CCNF

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR028857 CCNF_metazoan
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom

    Graphical View of Domain Structure for InterPro Entry P41002

    ProtoNet protein and cluster: P41002

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNF_HUMAN, P41002
    Domain: The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1
    localization to the nucleus
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily
    Similarity: Contains 1 cyclin N-terminal domain
    Similarity: Contains 1 F-box domain


    Find genes that share domains with CCNF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNF_HUMAN, P41002
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting
    as an inhibitor of centrosome reduplication

         Genatlas biochemistry entry for CCNF:
    cyclin F,involved in the regulation of cell cycle

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CCNF           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCNF:
     Decreased number of cells in m 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccnf):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     limbs/digits/tail  mortality/aging  nervous system  skeleton 

    Find genes that share phenotypes with CCNF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccnftm1.1Sje for CCNF

       genOway: Develop your customized and physiologically relevant rodent model for CCNF

    miRNA
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    miRTarBase miRNAs that target CCNF:
    hsa-mir-424-5p (MIRT000653), hsa-mir-423-5p (MIRT038126), hsa-mir-615-3p (MIRT040085), hsa-mir-503-5p (MIRT000643), hsa-let-7c-5p (MIRT051739), hsa-mir-98-5p (MIRT027780), hsa-mir-324-3p (MIRT042895), hsa-let-7b-5p (MIRT005061)

    Block miRNA regulation of human, mouse, rat CCNF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNF (see all 17):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-500a hsa-let-7g hsa-miR-4314 hsa-let-7a hsa-miR-331-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCNF 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNF
    Addgene plasmids for CCNF 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNF_HUMAN, P41002: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
    Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the
    mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the
    nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005814centriole IDA--
    GO:0019005SCF ubiquitin ligase complex IDA--

    Find genes that share ontologies with CCNF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNF About    
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    2GADD45 Pathway
    GADD45 Pathway

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNF
        GADD45 Pathway
    Pancreatic Adenocarcinoma


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNF: 
              Cell Cycle in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNF (P410021, 2, 3 ENSP000003802564) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCP110O433031, 2EBI-1207574,EBI-1566217 MINT-8397026 MINT-8396972
    SKP1P632081, ENSP000002314874EBI-1207574,EBI-307486 STRING: ENSP00000231487
    CCNB1P146353, ENSP000002564424I2D: score=5 STRING: ENSP00000256442
    RRM2P313501, ENSP000003029554EBI-1207574,EBI-2339245 STRING: ENSP00000302955
    CDK1P064933I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000320re-entry into mitotic cell cycle IEA--
    GO:0001890placenta development IEA--
    GO:0007067mitosis IEA--
    GO:0010826negative regulation of centrosome duplication IDA--
    GO:0016567protein ubiquitination IDA--

    Find genes that share ontologies with CCNF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNF



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNF gene: 
    NM_001761.2  

    Unigene Cluster for CCNF:

    Cyclin F
    Hs.1973  [show with all ESTs]
    Unigene Representative Sequence: NM_001761
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293968 ENST00000397066(uc002cqd.1 uc002cqe.1) ENST00000569093
    ENST00000564333 ENST00000564236
    miRNA
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    Block miRNA regulation of human, mouse, rat CCNF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNF (see all 17):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-500a hsa-let-7g hsa-miR-4314 hsa-let-7a hsa-miR-331-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCNF 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CCNF (NM_001761)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNF
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    OriGene qPCR primer pairs and template standards for CCNF
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNF
      QuantiTect SYBR Green Assays in human, mouse, rat CCNF
      QuantiFast Probe-based Assays in human, mouse, rat CCNF

    Additional mRNA sequence: 

    AB208829.1 AK172853.1 AK313371.1 BC012349.1 U17105.1 Z36714.1 

    5 DOTS entries:

    DT.312192  DT.97763304  DT.95161989  DT.97789764  DT.312193 

    Selected AceView cDNA sequences (see all 95):

    AW402106 BU164145 BQ951762 BQ215590 BQ223292 BM792099 BQ061685 BE467820 
    AW451030 BQ690469 BQ690697 BQ949803 BC012349 BM559197 AA996201 U17105 
    BX436486 BX283093 BM478195 BP364905 BM468245 CD612812 BQ052168 BQ062981 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                -                                                     -                                       
    SP2:                    -           -                                                     -                                       
    SP3:                    -           -                                                                                             
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CCNF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGAGCCTC
    CCNF Expression
    About this image


    CCNF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    CCNF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1973

    UniProtKB/Swiss-Prot: CCNF_HUMAN, P41002
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNF: 
              Cell Cycle in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCNF
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    QuantiTect SYBR Green Assays in human, mouse, rat CCNF
    QuantiFast Probe-based Assays in human, mouse, rat CCNF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCNF gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnf1 , 5 cyclin F1, 5 83.42(n)1
    84.54(a)1
      17 (12.32 cM)5
    124491  NM_007634.41  NP_031660.31 
     242232325 
    chicken
    (Gallus gallus)
    Aves CCNF1 cyclin F 70.14(n)
    69.23(a)
      416749  XM_415043.4  XP_415043.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691752 hypothetical protein MGC69175 73.29(n)    BC056134.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnf1 cyclin F 62.41(n)
    57.82(a)
      266981  NM_207048.1  NP_996931.1 


    ENSEMBL Gene Tree for CCNF (if available)
    TreeFam Gene Tree for CCNF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNF (see all 804)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1148058581,2
    C,F--2477468(+) TCCCAT/CGCCCC 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1822546321,2
    --2477690(+) CACACC/TCTGGA 1 -- us2k10--------
    rs1417471451,2
    --2477935(+) CTCATA/GGCTGG 1 -- us2k10--------
    rs45786471,2
    C,F,A,H--2478187(+) GAATAG/TTCCCA 1 -- us2k111Minor allele frequency- T:0.24NA WA CSA EA 257
    rs1507603641,2
    C--2478202(+) CCAGAC/TCCTCT 1 -- us2k10--------
    rs44129691,2
    C,F,A,H--2478253(+) CTGTTC/TACTCT 1 -- us2k122Minor allele frequency- T:0.22NS EA NA WA CSA 2350
    rs794847871,2
    C--2478297(+) CCAGGA/GCTCCT 1 -- us2k10--------
    rs66002061,2
    C,F,A,H--2478550(+) TGGGCT/ACTGCC 1 -- us2k114Minor allele frequency- A:0.19NA WA CSA EA 559
    rs344015521,2
    C--2478746(+) GACTTC/-CCAGC 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1873293641,2
    --2478761(+) GCTCCA/GACCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNF (2479395 - 2508859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CCNF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv905153CNV Loss21882294
    dgv2545n71CNV Loss21882294
    nsv905152CNV Loss21882294
    dgv2569n71CNV Loss21882294
    nsv905149CNV Loss21882294
    nsv905139CNV Loss21882294
    nsv833121CNV Loss17160897
    dgv2570n71CNV Loss21882294
    nsv827513CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600227    OMIM disorders: --

    1 disease for CCNF:    
    About MalaCards
    necrotizing fasciitis

    1 disease from the University of Copenhagen DISEASES database for CCNF:
    Necrotizing fasciitis

    Find genes that share disorders with CCNF           About GenesLikeMe

    1 Novoseek inferred disease relationship for CCNF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12878869 (1)


    Export disorders for CCNF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNF gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with CCNF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1). (PubMed id 7896286)1, 2, 3, 9 Kraus B.... Frischauf A.-M. (Genomics 1994)
    2. Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. (PubMed id 12122006)1, 2, 9 Fung T.K.... Poon R.Y. (J. Biol. Chem. 2002)
    3. Human cyclin F. (PubMed id 7813445)1, 2, 9 Bai C.... Elledge S.J. (EMBO J. 1994)
    4. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. (PubMed id 8706131)1, 2, 9 Bai C....Elledge S.J. (Cell 1996)
    5. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. (PubMed id 20596027)1, 2 D'Angiolella V.... Pagano M. (Nature 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. (PubMed id 10716937)1, 2 Kong M.... Donoghue D.J. (EMBO J. 2000)
    8. A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis. (PubMed id 23182110)1 D'Angiolella V....Pagano M. (Trends Cell Biol. 2013)
    9. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. (PubMed id 23486064)1 Li J.... Dynlacht B.D. (Nature 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 899 HGNC: 1591 AceView: CCNF Ensembl:ENSG00000162063 euGenes: HUgn899
    ECgene: CCNF H-InvDB: CCNF

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCNF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CCNF gene:
    Search GeneIP for patents involving CCNF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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