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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNE2 Gene

protein-coding   GIFtS: 62
GCID: GC08M095892

cyclin E2
 Explore 24 diseases affiliated with
CCNE2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCNE2    

Aliases
for CCNE2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin E21 2
CYCE21 2
G1/S-Specific Cyclin-E22

External Ids:    HGNC: 15901   Entrez Gene: 91342   Ensembl: ENSG000001753057   OMIM: 6037755   UniProtKB: O960203   

Export aliases for CCNE2 gene to outside databases

Previous GC identifers: GC08M094798 GC08M095864 GC08M095561 GC08M095849 GC08M095961 GC08M091101


Summaries
for CCNE2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCNE2:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.
Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination
of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has
been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S
transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct
from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020
Function: Essential for the control of the cell cycle at the late G1 and early S phase




Genomic Views
for CCNE2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNE2 gene promoter:
         AREB6   PPAR-gamma1   PPAR-gamma2   CUTL1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNE2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNE2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

CCNE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNE2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M095892:  view genomic region     (about GC identifiers)

Start:
 95,891,998 bp from pter      End:
 95,908,906 bp from pter
Size:
 16,909 bases      Orientation:
 minus strand

Proteins
for CCNE2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020 (See protein sequence)
Recommended Name: G1/S-specific cyclin-E2  
Size: 404 amino acids; 46757 Da
Subunit: Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase
holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex
Subcellular location: Nucleus
Secondary accessions: O95439
Alternative splicing: 2 isoforms:  O96020-1   O96020-2   

Explore the universe of human proteins at neXtProt for CCNE2: NX_O96020

Post-translational modifications:

  • Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway (By
    • similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O96020

    • CCNE2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_477097.1  
    ENSEMBL proteins: 
     ENSP00000429089   ENSP00000379437   ENSP00000430060   ENSP00000428988   ENSP00000430875  
     ENSP00000309181  
    Reactome Protein details: O96020
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CCNE2
    OriGene Custom Protein Services for CCNE2 
    GenScript Custom Purified and Recombinant Proteins Services for CCNE2
    Novus Biologicals CCNE2 Protein
    Novus Biologicals CCNE2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CCNE2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--


    CCNE2 for ontologies           About GeneDecksing



    CCNE2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNE2
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    Abcam antibodies for CCNE2 
    Uscn Antibodies for CCNE2
    ThermoFisher Antibodies for CCNE2

    Assay Products for CCNE2: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for CCNE2

    Protein Domains /
    Families
    for CCNE2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCNE2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry O96020

    ProtoNet protein and cluster: O96020

    1 Blocks protein family: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020
    Similarity: Belongs to the cyclin family. Cyclin E subfamily


    Function
    for CCNE2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020
    Function: Essential for the control of the cell cycle at the late G1 and early S phase
    Induction: Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively

    miRNA
    Products:            		miRTarBase miRNAs that target CCNE2:
    hsa-mir-126 (MIRT000965), hsa-mir-26a (MIRT000111), hsa-mir-34a (MIRT000768), hsa-mir-34c-5p (MIRT000766), hsa-mir-503 (MIRT000645), hsa-mir-34b (MIRT000767)

    OriGene 3'-UTR Clone: CCNE2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNE2
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNE2 (see all 36):
    hsa-miR-3164 hsa-miR-429 hsa-miR-25 hsa-miR-200a hsa-miR-16-1* hsa-miR-30d hsa-miR-449a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: CCNE2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNE2 (see all 7)
    OriGene shRNA RFP: CCNE2
    OriGene siRNA: CCNE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNE2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCNE2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCNE2 (NM_057749)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNE2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CCNE2
    Search LifeMap BioReagents cell lines for CCNE2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15232106
    GO:0016538cyclin-dependent protein kinase regulator activity IEA--
    GO:0019901protein kinase binding IEA--


    CCNE2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CCNE2:
     Increased S DNA content 

    Animal Models:
         Mouse knock-outs for CCNE2: Ccne2tm1Pisc Ccne2tm1Boa
         10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccne2):
     behavior/neurological  cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  mortality/aging  nervous system  normal  reproductive system 

    CCNE2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCNE2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/10 pathways (see all 10)
    		p53-Dependent G1/S DNA damage checkpoint0.83
    		Cyclin E associated events during G1/S transition 0.67
    		p53-Dependent G1 DNA Damage Response0.83
    		Cyclin A:Cdk2-associated events at S phase entry0.66
    		G1/S DNA Damage Checkpoints0.79
    		Cell Cycle Checkpoints0.42
    		Degradation of ubiquitinated p27/p21 by the 26S proteasome0.75
    		S Phase0.40
    2Cell cycle
    		Cell cycle1.00
    		G1 to S cell cycle control0.38
    		Cell cycle0.57
    3Cyclins and Cell Cycle Regulation
    		Cyclins and Cell Cycle Regulation1.00
    		Cell Cycle Control by BTG Proteins0.36
    		G1-S Phase Transition0.67
    4G1/S Transition
    		G1/S Transition1.00
    		Mitotic G1-G1/S phases0.80
    5Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CCNE2
        Transcription Ligand-dependent activation of the ESR1/SP pathway

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNE2 (see all 12)
        Cell Cycle Control by BTG Proteins
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    TOB in T-Cell Signaling
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for CCNE2
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for CCNE2
        Transcription Ligand-dependent activation of the ESR1/SP pathway

    5 BioSystems Pathways for CCNE2 
        G1 to S cell cycle control
    Parkinsons Disease Pathway
    Cell cycle
    DNA damage response
    E2F transcription factor network

    5/15        Reactome Pathways for CCNE2 (see all 15)
        SCF(Skp2)-mediated degradation of p27/p21
    Mitotic G1-G1/S phases
    G0 and Early G1
    Cell Cycle
    Degradation of ubiquitinated p27/p21 by the 26S proteasome


    5/7         Kegg Pathways  (Kegg details for CCNE2) (see all 7):
        Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    Measles
    Pathways in cancer


    CCNE2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for CCNE2 (O960201, 2, 3 ENSP000003091814) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249411, 3, ENSP000002669704EBI-375033,EBI-375096 I2D: score=6 STRING: ENSP00000266970
    CDKN1BP465271, 3, ENSP000002288724EBI-375033,EBI-519280 I2D: score=3 STRING: ENSP00000228872
    CDKN1AP389361, 3, ENSP000002447414EBI-375033,EBI-375077 I2D: score=4 STRING: ENSP00000244741
    ORC3Q9UBD53, ENSP000002577894I2D: score=4 STRING: ENSP00000257789
    CDK3Q005263, ENSP000004000884I2D: score=2 STRING: ENSP00000400088
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS9858585
    GO:0000079regulation of cyclin-dependent protein kinase activity IEA--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006270DNA replication initiation IEA--


    CCNE2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCNE2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCNE2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNE2
    1 Novoseek chemical compound relationship for CCNE2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 34.9 10 19564413 (6)

    Search CenterWatch for drugs/clinical trials and news about CCNE2 

    Transcripts
    for CCNE2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCNE2 gene (3 alternative transcripts): 
    NM_057749.2  NM_004702.2  NM_057735.1  

    Unigene Cluster for CCNE2:

    Cyclin E2
    Hs.521693  [show with all ESTs]
    Unigene Representative Sequence: NM_057749
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520509 ENST00000396133(uc003yhd.2) ENST00000524224 ENST00000523476
    ENST00000521809 ENST00000519889 ENST00000517487 ENST00000308108(uc003yhc.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: CCNE2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNE2
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNE2 (see all 36):
    hsa-miR-3164 hsa-miR-429 hsa-miR-25 hsa-miR-200a hsa-miR-16-1* hsa-miR-30d hsa-miR-449a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: CCNE2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNE2 (see all 7)
    OriGene shRNA RFP: CCNE2
    OriGene siRNA: CCNE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNE2
    Clone
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    GenScript: all cDNA clones in your preferred vector: CCNE2 (NM_057749)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNE2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNE2

    Additional cDNA sequence: 

    AF091433.1 AF102778.1 AF106690.1 AF112857.1 BC020729.1 

    8 DOTS entries:

    DT.95292667  DT.97858502  DT.100816549  DT.313997  DT.75145530  DT.121467030  DT.121467076  DT.95116698 

    24/93 AceView cDNA sequences (see all 93):

    AA731030 AA361674 AF112857 AF106690 BX279557 AA215483 BC007015 AA769139 
    BX098825 BC020729 AL710946 AA430417 AA436738 BU754368 AI094716 AA430368 
    AL597513 AF102778 AA830205 NM_004702 AV718083 BI222712 BX502606 AV718081 

    GeneLoc Exon Structure


    Expression
    for CCNE2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAACTTGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCNE2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordXX Germ CellsFemale Gametocytes, Germ Cells
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    OvaryOvigerous CordOvary
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CCNE2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNE2

    SOURCE GeneReport for Unigene cluster: Hs.521693

    UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020
    Tissue specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower
    levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed
    proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney.
    Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a
    lesser extent in small intestine and colon

        SABiosciences Expression via Pathway-Focused PCR Array including CCNE2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNE2
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNE2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNE2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE2

    Orthologs
    for CCNE2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNE2 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCNE21 cyclin E2 74.64(n)
    77.83(a)    		   420231  NM_001030945.1  NP_001026116.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CCNE26
    		 --
    		 73(a)
    		 1 ↔ 1
    		 4(19330083-19345497)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ccne2-prov2 cyclin E2 74.3(n)    BC043855.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.180812 Transcribed sequence with weak similarity to protein more 73.58(n)    CF997944.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CycE3 G1/S transition of mitotic cell cycle
    cyclin-dependent more    		 40(a)   35D4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea cye-13 Expression: seam cells, P lineage, VPC,
    intestinal, more    		 31(a)   I(6788885-6791944)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SDS6
    		 cyclin-SDS
    		 7(a)
    		 possible ortholog
    		 1(5079407-5082520)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 cyclin, putative, expressed
    		 11(a)
    		 possible ortholog
    		 3(6555387-6561025)


    ENSEMBL Gene Tree for CCNE2 (if available)
    TreeFam Gene Tree for CCNE2 (if available) 

    Paralogs
    for CCNE2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNE2 gene
    CCND32  CCNO2  CCNE12  CCNB22  CCNB32  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  
    4 SIMAP similar genes for CCNE2 using alignment to 7 protein entries:     CCNE2_HUMAN (see all proteins):
    CCNB1    CCNB1V    CCNB2V    CCNE1

    CCNE2 for paralogs           About GeneDecksing



    Genomic Variants
    for CCNE2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/299 NCBI SNPs in CCNE2 are shown (see all 299)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1155794961,2
    		C,F,--91099961(+) TACCAT/CAGTGC 2 -- int1 ds50011Minor allele frequency- C:0.02WA 118
    rs283995891,2
    		C,F,H,--91100957(-) AGTGTG/AACTAA 2 -- ut31 int18Minor allele frequency- A:0.02NS NA 1032
    rs753546151,2
    		--91101102(+) TGTCAA/TGAAAG 2 -- ut31 int11Minor allele frequency- T:0.01EA 120
    rs758764781,2
    		C,F,--91101231(+) TATGGC/AAAGGC 1 -- ut311Minor allele frequency- A:0.07WA 118
    rs283995881,2
    		C,F,--91101422(-) TGTTAG/CATTCT 1 -- ut31 ese33Minor allele frequency- C:0.04NS WA NA 414
    rs283995871,2
    		C,F,H,--91101565(-) GTCTAT/CACCAT 1 -- ut3113Minor allele frequency- C:0.03NS NA WA 1890
    rs283995861,2
    		C,F,H,--91101684(-) TTACAA/GTTGGC 1 -- ut31 ese35Minor allele frequency- G:0.02NS NA EA 476
    rs169171061,2
    		C,F,H,--91102221(+) TGCCCC/ATTAGA 1 -- int122Minor allele frequency- A:0.19NA NS EA WA CSA 2534
    rs283995841,2
    		C,F,--91102230(-) AAAGAA/TAGTTC 1 -- int1 trp38Minor allele frequency- T:0.02NS NA 962
    rs609949071,2
    		--91102645(+) TCACTC/TTCAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCNE2 (95891998 - 95908906 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCNE2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNE2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNE2

    Disorders / Diseases
    for CCNE2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCNE2 for disorders           About GeneDecksing

    OMIM gene information: 603775    OMIM disorders: --

    20/24 diseases for CCNE2 (see all 24):    About MalaCards
    oral squamous cell carcinoma    squamous cell carcinoma    multiple myeloma    ovarian cancer
    papilloma    endometrial carcinoma    measles    breast cancer
    acute leukemia    myeloma    rhabdomyosarcoma    retinoblastoma
    colorectal cancer    lung cancer    carcinoma    prostate cancer
    leukemia    prostatitis    melanoma    adenocarcinoma

    6 Novoseek disease relationships for CCNE2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solid tumor 26.4 2 16638210 (1), 12466974 (1)
    breast cancer 24.1 4 14510182 (1), 12466974 (1), 19564413 (1), 16740753 (1)
    primary tumor 23 1 11854029 (1)
    cancer 21.2 5 19084516 (2), 11212263 (1), 9858585 (1), 20180967 (1)
    tumors 19.3 8 12466974 (4), 18345025 (1), 17974993 (1), 16740753 (1) (see all 5)
    metastasis 9.01 1 19107233 (1)

    Human Genome Epidemiology (HuGE) Navigator: CCNE2 (1 document)

    Export disorders for CCNE2 gene to outside databases

    Publications
    for CCNE2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNE2 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with CCNE2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. (PubMed id 9840927)1, 2, 3, 9 Lauper N.... Amati B. (1998)
    2. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PubMed id 9840943)1, 2, 3, 9 Zariwala M.... Xiong Y. (1998)
    3. Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. (PubMed id 9858585)1, 2, 9 Gudas J.M....Coats S. (1999)
    4. Estrogen regulation of cyclin E2 requires cyclin D1 b ut not c-Myc. (PubMed id 19564413)1, 9 Caldon C.E....Musgrove E.A. (2009)
    5. Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis. (PubMed id 19107233)1, 9 Wu Z....Theodorescu D. (2009)
    6. Deregulation of cyclin E2 expression and associated kinase activity in primary breast tumors. (PubMed id 12466974)1, 9 Payton M....Coats S. (2002)
    7. SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-depe ndent proteolysis. (PubMed id 19084516)1, 9 Klotz K....Spruck C. (2009)
    8. Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer ce lls. (PubMed id 19638577)1, 9 Masamha C.P. and Benbrook D.M. (2009)
    9. Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patients. (PubMed id 16740753)1, 9 Sieuwerts A.M....Foekens J.A. (2006)
    10. [Expression and clinical significance of cyclin E2 in nasopharyngeal carcinoma]. (PubMed id 22394640)1 Zhao G.H....Miao Y.Y. (2012)

    External Searches for CCNE2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCNE2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9134 HGNC: 1590 AceView: CCNE2 Ensembl:ENSG00000175305 euGenes: HUgn9134
    ECgene: CCNE2 Kegg: 9134 H-InvDB: CCNE2

    Other Databases showing CCNE2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCNE2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNE2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNE2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccne2/

    Intellectual Property
    for CCNE2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCNE2 gene:
    Search GeneIP for patents involving CCNE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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