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Aliases for CCNE2 Gene

Aliases for CCNE2 Gene

  • Cyclin E2 2 3 5
  • G1/S-Specific Cyclin-E2 3
  • CYCE2 3

External Ids for CCNE2 Gene

Previous GeneCards Identifiers for CCNE2 Gene

  • GC08M095864
  • GC08M095561
  • GC08M095849
  • GC08M095961
  • GC08M095892
  • GC08M091101

Summaries for CCNE2 Gene

Entrez Gene Summary for CCNE2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNE2 Gene

CCNE2 (Cyclin E2) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Cyclins and Cell Cycle Regulation. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot for CCNE2 Gene

  • Essential for the control of the cell cycle at the late G1 and early S phase.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE2 Gene

Genomics for CCNE2 Gene

Regulatory Elements for CCNE2 Gene

Enhancers for CCNE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G095223 1.6 Ensembl ENCODE dbSUPER 10.3 -328.6 -328625 4.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143 ENSG00000254248 PLEKHF2 CCNE2 C8orf37 LINC01298 TRS-AGA2-5
GH08G094990 1.3 Ensembl ENCODE dbSUPER 10.7 -94.3 -94286 1.1 FOXA2 PKNOX1 NFIB RAD21 RCOR1 CREM MIXL1 ELF1 PPARG ZNF217 ENSG00000253878 TP53INP1 CCNE2 RNU6-1209P GC08P094978
GH08G095024 1.1 ENCODE 11.6 -128.5 -128504 2.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 TP53INP1 LOC105375650 ENSG00000253878 CCNE2 RNU6-1209P ENSG00000254307 GC08P094978
GH08G094822 1.1 ENCODE 11.3 +73.0 73013 2.6 PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 TP53INP1 INTS8 CCNE2 ENSG00000254307 ENSG00000253878 ESRP1 NDUFAF6 ENSG00000272509
GH08G094862 0.8 Ensembl ENCODE 11.6 +33.8 33751 1.6 HDGF CEBPB MAX FOXP2 CEBPG MYC INTS8 TP53INP1 CCNE2 ENSG00000253878 NDUFAF6 ENSG00000272509
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNE2 on UCSC Golden Path with GeneCards custom track

Promoters for CCNE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CCNE2 Gene

94,879,770 bp from pter
94,896,678 bp from pter
16,909 bases
Minus strand

Genomic View for CCNE2 Gene

Genes around CCNE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE2 Gene

Proteins for CCNE2 Gene

  • Protein details for CCNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G1/S-specific cyclin-E2
    Protein Accession:
    Secondary Accessions:
    • O95439

    Protein attributes for CCNE2 Gene

    404 amino acids
    Molecular mass:
    46757 Da
    Quaternary structure:
    • Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

    Alternative splice isoforms for CCNE2 Gene


neXtProt entry for CCNE2 Gene

Post-translational modifications for CCNE2 Gene

  • Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNE2 Gene

Domains & Families for CCNE2 Gene

Gene Families for CCNE2 Gene

Protein Domains for CCNE2 Gene

Suggested Antigen Peptide Sequences for CCNE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin E subfamily.
  • Belongs to the cyclin family. Cyclin E subfamily.
genes like me logo Genes that share domains with CCNE2: view

Function for CCNE2 Gene

Molecular function for CCNE2 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the late G1 and early S phase.
UniProtKB/Swiss-Prot Induction:
Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.

Gene Ontology (GO) - Molecular Function for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9840943
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNE2: view
genes like me logo Genes that share phenotypes with CCNE2: view

Animal Models for CCNE2 Gene

MGI Knock Outs for CCNE2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCNE2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNE2 Gene

Localization for CCNE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNE2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0097135 cyclin E2-CDK2 complex IEA --
genes like me logo Genes that share ontologies with CCNE2: view

Pathways & Interactions for CCNE2 Gene

genes like me logo Genes that share pathways with CCNE2: view

Gene Ontology (GO) - Biological Process for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint TAS 9858585
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9840943
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000723 telomere maintenance IEA --
GO:0006270 DNA replication initiation IEA --
genes like me logo Genes that share ontologies with CCNE2: view

No data available for SIGNOR curated interactions for CCNE2 Gene

Drugs & Compounds for CCNE2 Gene

(1) Drugs for CCNE2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCNE2: view

Transcripts for CCNE2 Gene

Unigene Clusters for CCNE2 Gene

Cyclin E2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCNE2

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE2 Gene

No ASD Table

Relevant External Links for CCNE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1).

Protein differential expression in normal tissues from HIPED for CCNE2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNE2 Gene

Protein tissue co-expression partners for CCNE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNE2 Gene:


SOURCE GeneReport for Unigene cluster for CCNE2 Gene:


mRNA Expression by UniProt/SwissProt for CCNE2 Gene:

Tissue specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.

Evidence on tissue expression from TISSUES for CCNE2 Gene

  • Lung(4.3)
  • Skin(4.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with CCNE2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNE2 Gene

Orthologs for CCNE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCNE2 34 35
  • 99.01 (n)
(Bos Taurus)
Mammalia CCNE2 34 35
  • 94.55 (n)
(Canis familiaris)
Mammalia CCNE2 34 35
  • 92.93 (n)
(Mus musculus)
Mammalia Ccne2 34 16 35
  • 89.66 (n)
(Rattus norvegicus)
Mammalia Ccne2 34
  • 89.5 (n)
(Ornithorhynchus anatinus)
Mammalia CCNE2 35
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
-- 35
  • 76 (a)
-- 35
  • 69 (a)
(Gallus gallus)
Aves CCNE2 34 35
  • 74.64 (n)
(Anolis carolinensis)
Reptilia CCNE2 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccne2 34
  • 66.5 (n)
Str.20470 34
African clawed frog
(Xenopus laevis)
Amphibia ccne2-prov 34
(Danio rerio)
Actinopterygii ccne2 34 35
  • 62.27 (n)
Dr.18081 34
fruit fly
(Drosophila melanogaster)
Insecta CycE 36 35
  • 40 (a)
(Caenorhabditis elegans)
Secernentea cye-1 36 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB6 35
  • 18 (a)
CLB1 35
  • 17 (a)
CLB3 35
  • 17 (a)
CLB2 35
  • 16 (a)
CLB5 35
  • 16 (a)
CLB4 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
Species where no ortholog for CCNE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNE2 Gene

Gene Tree for CCNE2 (if available)
Gene Tree for CCNE2 (if available)

Paralogs for CCNE2 Gene

Paralogs for CCNE2 Gene

(4) SIMAP similar genes for CCNE2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CCNE2: view

Variants for CCNE2 Gene

Sequence variations from dbSNP and Humsavar for CCNE2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000142631 -- 94,892,139(+) AAGTG(-/A)AAAAA intron-variant
rs1000355678 -- 94,891,054(+) GGAAA(C/T)AATTT intron-variant
rs1000370794 -- 94,897,888(+) GGCAT(A/G)TATAG intron-variant, upstream-variant-2KB
rs1000636233 -- 94,884,416(+) ATCTC(A/G)GCTCA intron-variant, utr-variant-3-prime
rs1000989360 -- 94,896,365(+) GGGGG(C/T)CCGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCNE2 Gene

Variant ID Type Subtype PubMed ID
nsv6314 CNV insertion 18451855
nsv971685 CNV duplication 23825009

Variation tolerance for CCNE2 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE2 Gene

Disorders for CCNE2 Gene

Relevant External Links for CCNE2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCNE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNE2 Gene

Publications for CCNE2 Gene

  1. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. (PMID: 9840927) Lauper N. … Amati B. (Oncogene 1998) 2 3 4 22 64
  2. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PMID: 9840943) Zariwala M. … Xiong Y. (Oncogene 1998) 2 3 4 22 64
  3. Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. (PMID: 9858585) Gudas J.M. … Coats S. (Mol. Cell. Biol. 1999) 3 4 22 64
  4. Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells. (PMID: 19638577) Masamha C.P. … Benbrook D.M. (Cancer Res. 2009) 3 22 64
  5. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham J.M. … Goode E.L. (Br. J. Cancer 2009) 3 46 64

Products for CCNE2 Gene

  • Addgene plasmids for CCNE2

Sources for CCNE2 Gene

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