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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCNE2 Gene

protein-coding GIFtS: 62
GCID: GC08M095892

cyclin E2

Explore 24 diseases affiliated with
CCNE2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin E2¹ ²
CYCE2¹ ²
G1/S-Specific Cyclin-E2²

External Ids:	HGNC: 1590¹	Entrez Gene: 9134²	Ensembl: ENSG00000175305⁷	OMIM: 603775⁵	UniProtKB: O96020³

Export aliases for CCNE2 gene to outside databases

Previous GC identifers: GC08M094798 GC08M095864 GC08M095561 GC08M095849 GC08M095961 GC08M091101

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNE2:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a

dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination

of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has

been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S

transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct

from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020

Function: Essential for the control of the cell cycle at the late G1 and early S phase

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNE2 gene promoter:
AREB6 PPAR-gamma1 PPAR-gamma2 CUTL1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNE2 promoter sequence

Search SABiosciences Chromatin IP Primers for CCNE2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNE2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1

CCNE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNE2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M095892: view genomic region (about GC identifiers)

Start:	95,891,998 bp from pter	End:	95,908,906 bp from pter
Size:	16,909 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020 (See protein sequence)

Recommended Name: G1/S-specific cyclin-E2

Size: 404 amino acids; 46757 Da

Subunit: Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase

holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex

Subcellular location: Nucleus

Secondary accessions: O95439

Alternative splicing: 2 isoforms: O96020-1 O96020-2

Explore the universe of human proteins at neXtProt for CCNE2: NX_O96020

Post-translational modifications:

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway (By

similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O96020

CCNE2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_477097.1

ENSEMBL proteins:

ENSP00000429089 ENSP00000379437 ENSP00000430060 ENSP00000428988 ENSP00000430875

ENSP00000309181

Reactome Protein details: O96020
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CCNE2 Protein Novus Biologicals CCNE2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CCNE2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--

CCNE2 for ontologies About GeneDecksing

CCNE2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNE2
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	Cell Signaling Technology (CST) Antibodies for CCNE2
	OriGene Antibodies (see all 3): CCNE2 OriGene Custom Antibody Services for CCNE2
	GenScript Custom Superior Antibodies Services for CCNE2
	Novus Biologicals CCNE2 Antibodies
	Abcam antibodies for CCNE2
	Uscn Antibodies for CCNE2
	ThermoFisher Antibodies for CCNE2

Assay Products for CCNE2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCNE2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCNE2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCNE2 for domains About GeneDecksing

4 InterPro domains/families:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR004367 Cyclin_C

IPR014400 Cyclin_A/B/D/E

Graphical View of Domain Structure for InterPro Entry O96020

ProtoNet protein and cluster: O96020

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020

Similarity: Belongs to the cyclin family. Cyclin E subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020

Function: Essential for the control of the cell cycle at the late G1 and early S phase

Induction: Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively

miRNA Products:		miRTarBase miRNAs that target CCNE2: hsa-mir-126 (MIRT000965), hsa-mir-26a (MIRT000111), hsa-mir-34a (MIRT000768), hsa-mir-34c-5p (MIRT000766), hsa-mir-503 (MIRT000645), hsa-mir-34b (MIRT000767)

		OriGene 3'-UTR Clone: CCNE2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNE2
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNE2 (see all 36):
		hsa-miR-3164 hsa-miR-429 hsa-miR-25 hsa-miR-200a hsa-miR-16-1* hsa-miR-30d hsa-miR-449a hsa-miR-374c

		SwitchGear 3'UTR luciferase reporter plasmid: CCNE2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNE2 (see all 7) OriGene shRNA RFP: CCNE2 OriGene siRNA: CCNE2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNE2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCNE2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCNE2 (NM_057749)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNE2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNE2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCNE2
		Search LifeMap BioReagents cell lines for CCNE2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15232106
GO:0016538	cyclin-dependent protein kinase regulator activity	IEA	--
GO:0019901	protein kinase binding	IEA	--

CCNE2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CCNE2:

Increased S DNA content

Animal Models:
Mouse knock-outs for CCNE2: Ccne2^tm1Pisc Ccne2^tm1Boa
10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ccne2):

behavior/neurological	cardiovascular system	embryogenesis	endocrine/exocrine gland	growth/size
hematopoietic system	mortality/aging	nervous system	normal	reproductive system

CCNE2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/10 pathways (see all 10)
p53-Dependent G1/S DNA damage checkpoint	0.83	Cyclin E associated events during G1/S transition	0.67
p53-Dependent G1 DNA Damage Response	0.83	Cyclin A:Cdk2-associated events at S phase entry	0.66
G1/S DNA Damage Checkpoints	0.79	Cell Cycle Checkpoints	0.42
Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75	S Phase	0.40

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Cyclins and Cell Cycle Regulation

	Cyclins and Cell Cycle Regulation	1.00			Cell Cycle Control by BTG Proteins	0.36
	G1-S Phase Transition	0.67

G1/S Transition

G1/S Transition

1.00

Mitotic G1-G1/S phases

0.80

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CCNE2

Transcription Ligand-dependent activation of the ESR1/SP pathway

5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNE2 (see all 12)

	Cell Cycle Control by BTG Proteins
	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	TOB in T-Cell Signaling
	Glioblastoma Multiforme

1 Cell Signaling Technology (CST) Pathway for CCNE2

Cell Cycle / Checkpoint Control

1 GeneGo (Thomson Reuters) Pathway for CCNE2

Transcription Ligand-dependent activation of the ESR1/SP pathway

5 BioSystems Pathways for CCNE2

	G1 to S cell cycle control
	Parkinsons Disease Pathway
	Cell cycle
	DNA damage response
	E2F transcription factor network

5/15 Reactome Pathways for CCNE2 (see all 15)

	SCF(Skp2)-mediated degradation of p27/p21
	Mitotic G1-G1/S phases
	G0 and Early G1
	Cell Cycle
	Degradation of ubiquitinated p27/p21 by the 26S proteasome

5/7 Kegg Pathways (Kegg details for CCNE2) (see all 7):

	Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	Measles
	Pathways in cancer

CCNE2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNE2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for CCNE2 (O96020^{1, 2, 3} ENSP00000309181⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK2	P24941¹^,³, ENSP00000266970⁴	EBI-375033,EBI-375096 I2D: score=6 STRING: ENSP00000266970
CDKN1B	P46527¹^,³, ENSP00000228872⁴	EBI-375033,EBI-519280 I2D: score=3 STRING: ENSP00000228872
CDKN1A	P38936¹^,³, ENSP00000244741⁴	EBI-375033,EBI-375077 I2D: score=4 STRING: ENSP00000244741
ORC3	Q9UBD5³, ENSP00000257789⁴	I2D: score=4 STRING: ENSP00000257789
CDK3	Q00526³, ENSP00000400088⁴	I2D: score=2 STRING: ENSP00000400088

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	9858585
GO:0000079	regulation of cyclin-dependent protein kinase activity	IEA	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006270	DNA replication initiation	IEA	--

CCNE2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCNE2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCNE2
1 Novoseek chemical compound relationship for CCNE2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen	34.9	10	19564413 (6)

Search CenterWatch for drugs/clinical trials and news about CCNE2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCNE2 gene (3 alternative transcripts):

NM_057749.2 NM_004702.2 NM_057735.1

Unigene Cluster for CCNE2:

Cyclin E2

Hs.521693 [show with all ESTs]

Unigene Representative Sequence: NM_057749

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000520509 ENST00000396133(uc003yhd.2) ENST00000524224 ENST00000523476

ENST00000521809 ENST00000519889 ENST00000517487 ENST00000308108(uc003yhc.3)

miRNA Products:		OriGene 3'-UTR Clone: CCNE2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNE2
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNE2 (see all 36):
		hsa-miR-3164 hsa-miR-429 hsa-miR-25 hsa-miR-200a hsa-miR-16-1* hsa-miR-30d hsa-miR-449a hsa-miR-374c

		SwitchGear 3'UTR luciferase reporter plasmid: CCNE2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNE2 (see all 7) OriGene shRNA RFP: CCNE2 OriGene siRNA: CCNE2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNE2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCNE2 (NM_057749)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNE2
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNE2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNE2

Additional cDNA sequence:

AF091433.1 AF102778.1 AF106690.1 AF112857.1 BC020729.1

8 DOTS entries:

DT.95292667 DT.97858502 DT.100816549 DT.313997 DT.75145530 DT.121467030 DT.121467076 DT.95116698

24/93 AceView cDNA sequences (see all 93):

AA731030 AA361674 AF112857 AF106690 BX279557 AA215483 BC007015 AA769139

BX098825 BC020729 AL710946 AA430417 AA436738 BU754368 AI094716 AA430368

AL597513 AF102778 AA830205 NM_004702 AV718083 BI222712 BX502606 AV718081

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCNE2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAACTTGCT

About this image

CCNE2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovigerous Cord

XX Germ Cells

Female Gametocytes, Germ Cells

Reproductive System

Ovary

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCNE2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNE2

SOURCE GeneReport for Unigene cluster: Hs.521693

UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020

Tissue specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower

levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed

proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney.

Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a

lesser extent in small intestine and colon

SABiosciences Expression via Pathway-Focused PCR Array including CCNE2:

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNE2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCNE2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNE2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNE2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNE2 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCNE2¹	cyclin E2	74.64(n) 77.83(a)		420231 NM_001030945.1 NP_001026116.1
lizard (Anolis carolinensis)	Reptilia	CCNE2⁶	--	73(a)	1 ↔ 1	4(19330083-19345497)
African clawed frog (Xenopus laevis)	Amphibia	ccne2-prov²	cyclin E2	74.3(n)		BC043855.1
zebrafish (Danio rerio)	Actinopterygii	Dr.18081²	Transcribed sequence with weak similarity to protein more	73.58(n)		CF997944.1
fruit fly (Drosophila melanogaster)	Insecta	CycE³	G1/S transition of mitotic cell cycle cyclin-dependent more	40(a)		35D4 --
worm (Caenorhabditis elegans)	Secernentea	cye-1³	Expression: seam cells, P lineage, VPC, intestinal, more	31(a)		I(6788885-6791944) --
thale cress (Arabidopsis thaliana)	eudicotyledons	SDS⁶	cyclin-SDS	7(a)	possible ortholog	1(5079407-5082520)
rice (Oryza sativa)	Liliopsida	--	cyclin, putative, expressed	11(a)	possible ortholog	3(6555387-6561025)

ENSEMBL Gene Tree for CCNE2 (if available)
TreeFam Gene Tree for CCNE2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCNE2 gene

CCND3² CCNO² CCNE1² CCNB2² CCNB3² CCNB1² CCND1² CCNA1²

CCND2² CCNA2²

4 SIMAP similar genes for CCNE2 using alignment to 7 protein entries: CCNE2_HUMAN (see all proteins):

CCNB1 CCNB1V CCNB2V CCNE1

CCNE2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115579496^1,2	C,F,	--	91099961(+)	`TACCAT/CAGTGC`	2	--	int¹ ds500¹		1		WA	118
rs28399589^1,2	C,F,H,	--	91100957(-)	`AGTGTG/AACTAA`	2	--	ut3¹ int¹		8		NS NA	1032
rs75354615^1,2		--	91101102(+)	`TGTCAA/TGAAAG`	2	--	ut3¹ int¹		1		EA	120
rs75876478^1,2	C,F,	--	91101231(+)	`TATGGC/AAAGGC`	1	--	ut3¹		1		WA	118
rs28399588^1,2	C,F,	--	91101422(-)	`TGTTAG/CATTCT`	1	--	ut3¹ ese³		3		NS WA NA	414
rs28399587^1,2	C,F,H,	--	91101565(-)	`GTCTAT/CACCAT`	1	--	ut3¹		13		NS NA WA	1890
rs28399586^1,2	C,F,H,	--	91101684(-)	`TTACAA/GTTGGC`	1	--	ut3¹ ese³		5		NS NA EA	476
rs16917106^1,2	C,F,H,	--	91102221(+)	`TGCCCC/ATTAGA`	1	--	int¹		22		NA NS EA WA CSA	2534
rs28399584^1,2	C,F,	--	91102230(-)	`AAAGAA/TAGTTC`	1	--	int¹ trp³		8		NS NA	962
rs60994907^1,2		--	91102645(+)	`TCACTC/TTCAAA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCNE2 (95891998 - 95908906 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNE2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCNE2 for disorders           About GeneDecksing

OMIM gene information: 603775    OMIM disorders: --

20/24 diseases for CCNE2 (see all 24):    About MalaCards

oral squamous cell carcinoma squamous cell carcinoma multiple myeloma ovarian cancer

papilloma endometrial carcinoma measles breast cancer

acute leukemia myeloma rhabdomyosarcoma retinoblastoma

colorectal cancer lung cancer carcinoma prostate cancer

leukemia prostatitis melanoma adenocarcinoma

6 Novoseek disease relationships for CCNE2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
solid tumor	26.4	2	16638210 (1), 12466974 (1)
breast cancer	24.1	4	14510182 (1), 12466974 (1), 19564413 (1), 16740753 (1)
primary tumor	23	1	11854029 (1)
cancer	21.2	5	19084516 (2), 11212263 (1), 9858585 (1), 20180967 (1)
tumors	19.3	8	12466974 (4), 18345025 (1), 17974993 (1), 16740753 (1) (see all 5)
metastasis	9.01	1	19107233 (1)

Human Genome Epidemiology (HuGE) Navigator: CCNE2 (1 document)

Export disorders for CCNE2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCNE2 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with CCNE2)

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Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. (PubMed id 9840927)^{1, 2, 3, 9} Lauper N.... Amati B. (1998)
Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PubMed id 9840943)^{1, 2, 3, 9} Zariwala M.... Xiong Y. (1998)
Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. (PubMed id 9858585)^{1, 2, 9} Gudas J.M....Coats S. (1999)
Estrogen regulation of cyclin E2 requires cyclin D1 b ut not c-Myc. (PubMed id 19564413)^{1, 9} Caldon C.E....Musgrove E.A. (2009)
Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis. (PubMed id 19107233)^{1, 9} Wu Z....Theodorescu D. (2009)
Deregulation of cyclin E2 expression and associated kinase activity in primary breast tumors. (PubMed id 12466974)^{1, 9} Payton M....Coats S. (2002)
SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-depe ndent proteolysis. (PubMed id 19084516)^{1, 9} Klotz K....Spruck C. (2009)
Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer ce lls. (PubMed id 19638577)^{1, 9} Masamha C.P. and Benbrook D.M. (2009)
Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patients. (PubMed id 16740753)^{1, 9} Sieuwerts A.M....Foekens J.A. (2006)
[Expression and clinical significance of cyclin E2 in nasopharyngeal carcinoma]. (PubMed id 22394640)¹ Zhao G.H....Miao Y.Y. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9134	HGNC: 1590	AceView: CCNE2	Ensembl:ENSG00000175305	euGenes: HUgn9134
ECgene: CCNE2	Kegg: 9134	H-InvDB: CCNE2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCNE2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCNE2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccne2/

Intellectual Property for CCNE2 gene
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Patent Information for CCNE2 gene:
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