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CCNE2 Gene

protein-coding   GIFtS: 62
GCID: GC08M095892

Cyclin E2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin E21 2
CYCE22
G1/S-Specific Cyclin-E22

External Ids:    HGNC: 15901   Entrez Gene: 91342   Ensembl: ENSG000001753057   OMIM: 6037755   UniProtKB: O960203   

Export aliases for CCNE2 gene to outside databases

Previous GC identifers: GC08M094798 GC08M095864 GC08M095561 GC08M095849 GC08M095961 GC08M091101


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNE2 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role
in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of
tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was
observed in tumor-derived cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNE2 Gene:
CCNE2 (cyclin E2) is a protein-coding gene. Diseases associated with CCNE2 include measles, and oral squamous cell carcinoma. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020
Function: Essential for the control of the cell cycle at the late G1 and early S phase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNE2 gene promoter:
         AREB6   PPAR-gamma1   PPAR-gamma2   CUTL1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNE2 promoter sequence
   Search Chromatin IP Primers for CCNE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

CCNE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNE2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M095892:  view genomic region     (about GC identifiers)

Start:
95,891,998 bp from pter      End:
95,908,906 bp from pter
Size:
16,909 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020 (See protein sequence)
Recommended Name: G1/S-specific cyclin-E2  
Size: 404 amino acids; 46757 Da
Subunit: Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase
holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex
Secondary accessions: O95439
Alternative splicing: 2 isoforms:  O96020-1   O96020-2   

Explore the universe of human proteins at neXtProt for CCNE2: NX_O96020

Explore proteomics data for CCNE2 at MOPED

Post-translational modifications: 

  • Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCNE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_477097.1  
    ENSEMBL proteins: 
     ENSP00000429089   ENSP00000379437   ENSP00000430060   ENSP00000428988   ENSP00000430875  
     ENSP00000309181  
    Reactome Protein details: O96020

    CCNE2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCNE2
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    Novus Biologicals CCNE2 Protein
    Novus Biologicals CCNE2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNE2

    CCNE2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNE2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CCNE2 
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    Abcam antibodies for CCNE2
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    LSBio Antibodies in human, mouse, rat for CCNE2

    CCNE2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CCNE2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCNE2
    Cloud-Clone Corp. CLIAs for CCNE2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028858 Cyclin_E
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry O96020

    ProtoNet protein and cluster: O96020

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020
    Similarity: Belongs to the cyclin family. Cyclin E subfamily


    CCNE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNE2_HUMAN, O96020
    Function: Essential for the control of the cell cycle at the late G1 and early S phase
    Induction: Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb,
    respectively

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15232106
    GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity IEA--
    GO:0019901protein kinase binding IEA--
         
    CCNE2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCNE2:
     Increased S DNA content 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccne2):
     behavior/neurological  cardiovascular system  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  mortality/aging  nervous system  normal  reproductive system 

    CCNE2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CCNE2: Ccne2tm1Pisc Ccne2tm1Boa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNE2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCNE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNE2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCNE2:
    hsa-mir-126-3p (MIRT000965), hsa-mir-200c-3p (MIRT006667), hsa-mir-34c-5p (MIRT000766), hsa-mir-449a (MIRT006347), hsa-mir-196a-5p (MIRT048230), hsa-mir-34a-5p (MIRT000768), hsa-mir-503-5p (MIRT000645), hsa-mir-200a-3p (MIRT006665), hsa-mir-30b-5p (MIRT006303), hsa-mir-449b-5p (MIRT006350), hsa-mir-16-5p (MIRT031722), hsa-mir-32-5p (MIRT028325), hsa-mir-200b-3p (MIRT006666), hsa-mir-26a-5p (MIRT000111), hsa-mir-34b-5p (MIRT000767), hsa-mir-25-3p (MIRT050210)

    Block miRNA regulation of human, mouse, rat CCNE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNE2 (see all 36):
    hsa-miR-3164 hsa-miR-429 hsa-miR-25 hsa-miR-200a hsa-miR-16-1* hsa-miR-30d hsa-miR-449a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidCCNE2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCNE2
    Predesigned siRNA for gene silencing in human, mouse, rat CCNE2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CCNE2

    Clone
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    OriGene clones in human, mouse for CCNE2 (see all 7)
    OriGene ORF clones in mouse, rat for CCNE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCNE2 (NM_057749)
    Sino Biological Human cDNA Clone for CCNE2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNE2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCNE2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNE2_HUMAN, O96020: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    CCNE2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNE2 About   (see all 30)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    p53-Dependent G1/S DNA damage checkpoint0.92
    Cyclin A-Cdk2-associated events at S phase entry0.85
    p53-Dependent G1 DNA Damage Response0.92
    S Phase0.78
    G1/S DNA Damage Checkpoints0.87
    Cell Cycle Checkpoints0.58
    SCF(Skp2)-mediated degradation of p27/p210.86
    Parkinson's Disease Pathway0.31
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cell Cycle Control by BTG Proteins0.36
    G1-S Phase Transition0.67
    Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes0.00
    3E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    G1/S Transition0.81
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNE2 (see all 12)
        Cell Cycle Control by BTG Proteins
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    TOB in T-Cell Signaling
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for CCNE2
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for CCNE2
        Transcription Ligand-dependent activation of the ESR1/SP pathway

    Selected BioSystems Pathways for CCNE2 (see all 6)
        DNA damage response
    G1 to S cell cycle control
    Cell cycle
    Parkinsons Disease Pathway
    RB in Cancer


    Selected Reactome Pathways for CCNE2 (see all 6)
        SCF(Skp2)-mediated degradation of p27/p21
    G0 and Early G1
    Cyclin E associated events during G1/S transition
    Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
    p53-Dependent G1 DNA Damage Response


    Selected Kegg Pathways  (Kegg details for CCNE2) (see all 11):
        Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Hepatitis B


    CCNE2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CCNE2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNE2 (O960201, 2, 3 ENSP000003091814) via UniProtKB, MINT, STRING, and/or I2D (see all 218)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1AP389361, 3, ENSP000002447414EBI-375033,EBI-375077 I2D: score=4 STRING: ENSP00000244741
    CDKN1BP465271, 3, ENSP000002288724EBI-375033,EBI-519280 I2D: score=3 STRING: ENSP00000228872
    CDK2P249411, 3, ENSP000002669704EBI-375033,EBI-375096 I2D: score=6 STRING: ENSP00000266970
    ORC3Q9UBD53, ENSP000002577894I2D: score=4 STRING: ENSP00000257789
    CDK3Q005263, ENSP000004000884I2D: score=2 STRING: ENSP00000400088
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS9858585
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006270DNA replication initiation IEA--

    CCNE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNE2

    1 Novoseek inferred chemical compound relationship for CCNE2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 34.9 10 19564413 (6)



    CCNE2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCNE2 gene (3 alternative transcripts): 
    NM_057749.2  NM_004702.2  NM_057735.1  

    Unigene Cluster for CCNE2:

    Cyclin E2
    Hs.521693  [show with all ESTs]
    Unigene Representative Sequence: NM_057749
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520509 ENST00000396133(uc003yhd.2) ENST00000524224 ENST00000523476
    ENST00000521809 ENST00000519889 ENST00000517487 ENST00000308108(uc003yhc.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat CCNE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNE2 (see all 36):
    hsa-miR-3164 hsa-miR-429 hsa-miR-25 hsa-miR-200a hsa-miR-16-1* hsa-miR-30d hsa-miR-449a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidCCNE2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CCNE2 (NM_057749)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNE2
    Primer
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    OriGene qPCR primer pairs and template standards for CCNE2
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNE2
      QuantiTect SYBR Green Assays in human, mouse, rat CCNE2
      QuantiFast Probe-based Assays in human, mouse, rat CCNE2

    Additional mRNA sequence: 

    AF091433.1 AF102778.1 AF106690.1 AF112857.1 BC020729.1 

    8 DOTS entries:

    DT.95292667  DT.97858502  DT.100816549  DT.313997  DT.75145530  DT.121467030  DT.121467076  DT.95116698 

    Selected AceView cDNA sequences (see all 93):

    BC007015 AA430368 AF112857 AA436738 AF102778 AI094716 AA430417 AA361674 
    AA769139 AA215483 BX098825 AF106690 BC020729 AL710946 BX279557 AA731030 
    BU754368 AL597513 BX482908 NM_057735 BX502606 AV718081 AW175878 BU155934 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACTTGCT
    CCNE2 Expression
    About this image


    CCNE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             XX Germ Cells Ovigerous Cord
             Ovigerous Cord
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Gonad
             Mesonephric cells Mesonephros
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CCNE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521693

    UniProtKB/Swiss-Prot: CCNE2_HUMAN, O96020
    Tissue specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain.
    Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to
    non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal
    muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta,
    thymus and brain. In a lesser extent in small intestine and colon

        Pathway & Disease-focused RT2 Profiler PCR Array including CCNE2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

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    QuantiTect SYBR Green Assays in human, mouse, rat CCNE2
    QuantiFast Probe-based Assays in human, mouse, rat CCNE2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CCNE2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccne21 , 5 cyclin E21, 5 89.66(n)1
    92.31(a)1
      4 (5.07 cM)5
    124481  NM_009830.31  NP_033960.11 
     111913515 
    chicken
    (Gallus gallus)
    Aves CCNE21 cyclin E2 74.64(n)
    77.83(a)
      420231  NM_001030945.1  NP_001026116.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNE26
    cyclin E2
    75(a)
    1 ↔ 1
    4(19330146-19345598)
    African clawed frog
    (Xenopus laevis)
    Amphibia ccne2-prov2 cyclin E2 74.3(n)    BC043855.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.180812 Transcribed sequence with weak similarity to protein more 73.58(n)    CF997944.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycE3 G1/S transition of mitotic cell cycle
    cyclin-dependent more
    40(a)   35D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cye-13 Expression: seam cells, P lineage, VPC,
    intestinal, more
    31(a)   I(6788885-6791944)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLB66
    CLB16
    (see all 6)
    B-type cyclin involved in DNA replication during S...
    B-type cyclin involved in cell cycle progression; ...
    (see all 6)
    18(a)
    17(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    VII(705359-706501) YGR109C
    VII(703636-705051) YGR108W


    ENSEMBL Gene Tree for CCNE2 (if available)
    TreeFam Gene Tree for CCNE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNE2 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNB32  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  
    4 SIMAP similar genes for CCNE2 using alignment to 7 protein entries:     CCNE2_HUMAN (see all proteins):
    CCNB1    CCNB1V    CCNB2V    CCNE1

    CCNE2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNE2 (see all 371)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346041381,2
    C--91104545(+) TCCTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs169171171,2
    C,F,H--91117383(+) ATAAAT/CGTTCT 1 -- us2k126Minor allele frequency- C:0.12NA NS EA WA 2912
    rs1833808311,2
    --91117430(+) TCATAC/GTAAAG 1 -- us2k10--------
    rs113321051,2
    C--95896584(+) TTTTTA/C/TAATTT 1 -- int1 trp31NS 172
    rs784274211,2
    C,F--95901228(+) AAAATA/TTAGCA 1 -- int12Minor allele frequency- T:0.04WA NA 238
    rs339889051,2
    C--95902837(+) TTTTT-/TTGAGAC 1 -- int11Minor allele frequency- TT:0.00NA 2
    rs1164733441,2
    C,F--95904162(+) GCCAAC/TGGACC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1155794961,2
    C,F--96048987(+) TACCAT/CAGTGC 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1918238031,2
    C--96049027(+) AAGTGC/GAGCCC 1 -- ds50010--------
    rs1508877631,2
    C--96049035(+) CCTAG-/TTTTAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCNE2 (95891998 - 95908906 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCNE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6314CNV Insertion18451855
    dgv7835n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNE2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603775    OMIM disorders: --

    Selected diseases for CCNE2 (see all 27):    
    About MalaCards
    measles    oral squamous cell carcinoma    papilloma    glioblastoma multiforme
    nasopharyngitis    rhabdomyosarcoma    multiple myeloma    endometrial carcinoma
    acute leukemia    parkinson's disease    myeloma    retinoblastoma
    lung cancer    squamous cell carcinoma    ovarian cancer    breast cancer
    colorectal cancer    prostate cancer    melanoma    prostatitis


    CCNE2 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for CCNE2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    solid tumor 26.4 2 16638210 (1), 12466974 (1)
    breast cancer 24.1 4 14510182 (1), 12466974 (1), 19564413 (1), 16740753 (1)
    primary tumor 23 1 11854029 (1)
    cancer 21.2 5 19084516 (2), 11212263 (1), 9858585 (1), 20180967 (1)
    tumors 19.3 8 12466974 (4), 18345025 (1), 17974993 (1), 16740753 (1) (see all 5)
    metastasis 9.01 1 19107233 (1)

    Genetic Association Database (GAD): CCNE2
    Human Genome Epidemiology (HuGE) Navigator: CCNE2 (1 document)

    Export disorders for CCNE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNE2 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with CCNE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. (PubMed id 9840927)1, 2, 3, 9 Lauper N.... Amati B. (Oncogene 1998)
    2. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PubMed id 9840943)1, 2, 3, 9 Zariwala M.... Xiong Y. (Oncogene 1998)
    3. Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. (PubMed id 9858585)1, 2, 9 Gudas J.M....Coats S. (Mol. Cell. Biol. 1999)
    4. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    5. Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc. (PubMed id 19564413)1, 9 Caldon C.E....Musgrove E.A. (Mol. Cell. Biol. 2009)
    6. Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis. (PubMed id 19107233)1, 9 Wu Z....Theodorescu D. (Neoplasia 2009)
    7. Deregulation of cyclin E2 expression and associated kinase activity in primary breast tumors. (PubMed id 12466974)1, 9 Payton M....Coats S. (Oncogene 2002)
    8. SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis. (PubMed id 19084516)1, 9 Klotz K....Spruck C. (Exp. Cell Res. 2009)
    9. Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells. (PubMed id 19638577)1, 9 Masamha C.P. and Benbrook D.M. (Cancer Res. 2009)
    10. Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patients. (PubMed id 16740753)1, 9 Sieuwerts A.M....Foekens J.A. (Clin. Cancer Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9134 HGNC: 1590 AceView: CCNE2 Ensembl:ENSG00000175305 euGenes: HUgn9134
    ECgene: CCNE2 Kegg: 9134 H-InvDB: CCNE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNE2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNE2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccne2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNE2 gene:
    Search GeneIP for patents involving CCNE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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