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Aliases for CCNE2 Gene

Aliases for CCNE2 Gene

  • Cyclin E2 2 3
  • CYCE2 3

External Ids for CCNE2 Gene

Previous GeneCards Identifiers for CCNE2 Gene

  • GC08M095864
  • GC08M095561
  • GC08M095849
  • GC08M095961
  • GC08M095892
  • GC08M091101

Summaries for CCNE2 Gene

Entrez Gene Summary for CCNE2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNE2 Gene

CCNE2 (Cyclin E2) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNE2 Gene

  • Essential for the control of the cell cycle at the late G1 and early S phase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE2 Gene

Genomics for CCNE2 Gene

Regulatory Elements for CCNE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNE2 Gene

Chromosome:
8
Start:
94,879,770 bp from pter
End:
94,896,678 bp from pter
Size:
16,909 bases
Orientation:
Minus strand

Genomic View for CCNE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE2 Gene

Proteins for CCNE2 Gene

  • Protein details for CCNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96020-CCNE2_HUMAN
    Recommended name:
    G1/S-specific cyclin-E2
    Protein Accession:
    O96020
    Secondary Accessions:
    • O95439

    Protein attributes for CCNE2 Gene

    Size:
    404 amino acids
    Molecular mass:
    46757 Da
    Quaternary structure:
    • Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex

    Alternative splice isoforms for CCNE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNE2 Gene

Proteomics data for CCNE2 Gene at MOPED

Post-translational modifications for CCNE2 Gene

  • Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNE2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCNE2 (CCNE2)

No data available for DME Specific Peptides for CCNE2 Gene

Domains & Families for CCNE2 Gene

Gene Families for CCNE2 Gene

Protein Domains for CCNE2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O96020

UniProtKB/Swiss-Prot:

CCNE2_HUMAN :
  • Belongs to the cyclin family. Cyclin E subfamily.
Family:
  • Belongs to the cyclin family. Cyclin E subfamily.
genes like me logo Genes that share domains with CCNE2: view

Function for CCNE2 Gene

Molecular function for CCNE2 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the late G1 and early S phase
UniProtKB/Swiss-Prot Induction:
Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively

Gene Ontology (GO) - Molecular Function for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9840943
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNE2: view
genes like me logo Genes that share phenotypes with CCNE2: view

Animal Models for CCNE2 Gene

MGI Knock Outs for CCNE2:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNE2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCNE2 Gene

Localization for CCNE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNE2 Gene COMPARTMENTS Subcellular localization image for CCNE2 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CCNE2: view

Pathways & Interactions for CCNE2 Gene

genes like me logo Genes that share pathways with CCNE2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G-Protein-Coupled Receptor Signaling PathwayFinder in human,mouse,rat

Gene Ontology (GO) - Biological Process for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint TAS 9858585
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9840943
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006270 DNA replication initiation IEA --
genes like me logo Genes that share ontologies with CCNE2: view

No data available for SIGNOR curated interactions for CCNE2 Gene

Drugs & Compounds for CCNE2 Gene

(1) Drugs for CCNE2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
estrogen Pharma 0
genes like me logo Genes that share compounds with CCNE2: view

Transcripts for CCNE2 Gene

Unigene Clusters for CCNE2 Gene

Cyclin E2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNE2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE2 Gene

No ASD Table

Relevant External Links for CCNE2 Gene

GeneLoc Exon Structure for
CCNE2
ECgene alternative splicing isoforms for
CCNE2

Expression for CCNE2 Gene

mRNA expression in normal human tissues for CCNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1).

Protein differential expression in normal tissues from HIPED for CCNE2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNE2 Gene



SOURCE GeneReport for Unigene cluster for CCNE2 Gene Hs.521693

mRNA Expression by UniProt/SwissProt for CCNE2 Gene

O96020-CCNE2_HUMAN
Tissue specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon
genes like me logo Genes that share expression patterns with CCNE2: view

Protein tissue co-expression partners for CCNE2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CCNE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNE2 35
  • 94.55 (n)
  • 95.05 (a)
CCNE2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNE2 35
  • 92.93 (n)
  • 94.26 (a)
CCNE2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccne2 35
  • 89.66 (n)
  • 92.31 (a)
Ccne2 16
Ccne2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNE2 35
  • 99.01 (n)
  • 98.51 (a)
CCNE2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccne2 35
  • 89.5 (n)
  • 93.05 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCNE2 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNE2 35
  • 74.64 (n)
  • 77.83 (a)
CCNE2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNE2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccne2 35
  • 66.5 (n)
  • 65.56 (a)
Str.20470 35
African clawed frog
(Xenopus laevis)
Amphibia ccne2-prov 35
zebrafish
(Danio rerio)
Actinopterygii ccne2 35
  • 62.27 (n)
  • 61.5 (a)
Dr.18081 35
ccne2 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycE 37
  • 40 (a)
CycE 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cye-1 37
  • 31 (a)
cye-1 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB1 36
  • 17 (a)
ManyToMany
CLB2 36
  • 16 (a)
ManyToMany
CLB3 36
  • 17 (a)
ManyToMany
CLB4 36
  • 13 (a)
ManyToMany
CLB5 36
  • 16 (a)
ManyToMany
CLB6 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for CCNE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNE2 Gene

ENSEMBL:
Gene Tree for CCNE2 (if available)
TreeFam:
Gene Tree for CCNE2 (if available)

Paralogs for CCNE2 Gene

Paralogs for CCNE2 Gene

(4) SIMAP similar genes for CCNE2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CCNE2: view

Variants for CCNE2 Gene

Sequence variations from dbSNP and Humsavar for CCNE2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2278891 -- 94,883,474(-) AATGT(C/T)CCTAT intron-variant, downstream-variant-500B
rs2467670 -- 94,883,878(+) ATTCT(C/G)TTTGT intron-variant, utr-variant-3-prime
rs4269509 -- 94,886,252(+) AGATA(C/T)TTTCA intron-variant
rs7009940 -- 94,882,572(+) GATTC(A/G)TTTCA intron-variant
rs7835501 -- 94,893,032(+) ATGGA(A/T)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNE2 Gene

Variant ID Type Subtype PubMed ID
nsv6314 CNV Insertion 18451855
dgv7835n71 CNV Loss 21882294

Variation tolerance for CCNE2 Gene

Residual Variation Intolerance Score: 35.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNE2 Gene

HapMap Linkage Disequilibrium report
CCNE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE2 Gene

Disorders for CCNE2 Gene

Relevant External Links for CCNE2

Genetic Association Database (GAD)
CCNE2
Human Genome Epidemiology (HuGE) Navigator
CCNE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNE2
genes like me logo Genes that share disorders with CCNE2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNE2 Gene

Publications for CCNE2 Gene

  1. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PMID: 9840943) Zariwala M. … Xiong Y. (Oncogene 1998) 2 23 67
  2. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. (PMID: 9840927) Lauper N. … Amati B. (Oncogene 1998) 2 23 67
  3. Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer. (PMID: 20180967) Caldon C.E. … Musgrove E.A. (Cell Div 2010) 23 67
  4. Regulation of cell cycle and RNA transcription genes identified by microarray analysis of PC-3 human prostate cancer cells treated with luteolin. (PMID: 19837161) Shoulars K. … Markaverich B.M. (J. Steroid Biochem. Mol. Biol. 2010) 23 67
  5. Grade-dependent effects on cell cycle progression and apoptosis in response to doxorubicin in human bladder cancer cell lines. (PMID: 19082486) Stravopodis D.J. … Voutsinas G.E. (Int. J. Oncol. 2009) 23 67

Products for CCNE2 Gene

Sources for CCNE2 Gene

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