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Aliases for CCNE2 Gene

Aliases for CCNE2 Gene

  • Cyclin E2 2 3 5
  • CYCE2 3

External Ids for CCNE2 Gene

Previous GeneCards Identifiers for CCNE2 Gene

  • GC08M095864
  • GC08M095561
  • GC08M095849
  • GC08M095961
  • GC08M095892
  • GC08M091101

Summaries for CCNE2 Gene

Entrez Gene Summary for CCNE2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNE2 Gene

CCNE2 (Cyclin E2) is a Protein Coding gene. Among its related pathways are Packaging Of Telomere Ends and p53 Pathway (RnD). GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase regulator activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNE2 Gene

  • Essential for the control of the cell cycle at the late G1 and early S phase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE2 Gene

Genomics for CCNE2 Gene

Regulatory Elements for CCNE2 Gene

Enhancers for CCNE2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCNE2 on UCSC Golden Path with GeneCards custom track

Promoters for CCNE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNE2 Gene

94,879,770 bp from pter
94,896,678 bp from pter
16,909 bases
Minus strand

Genomic View for CCNE2 Gene

Genes around CCNE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE2 Gene

Proteins for CCNE2 Gene

  • Protein details for CCNE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G1/S-specific cyclin-E2
    Protein Accession:
    Secondary Accessions:
    • O95439

    Protein attributes for CCNE2 Gene

    404 amino acids
    Molecular mass:
    46757 Da
    Quaternary structure:
    • Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

    Alternative splice isoforms for CCNE2 Gene


neXtProt entry for CCNE2 Gene

Proteomics data for CCNE2 Gene at MOPED

Post-translational modifications for CCNE2 Gene

  • Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNE2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCNE2 (CCNE2)

No data available for DME Specific Peptides for CCNE2 Gene

Domains & Families for CCNE2 Gene

Gene Families for CCNE2 Gene

Protein Domains for CCNE2 Gene


Suggested Antigen Peptide Sequences for CCNE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin E subfamily.
  • Belongs to the cyclin family. Cyclin E subfamily.
genes like me logo Genes that share domains with CCNE2: view

Function for CCNE2 Gene

Molecular function for CCNE2 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the late G1 and early S phase.
UniProtKB/Swiss-Prot Induction:
Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.
genes like me logo Genes that share phenotypes with CCNE2: view

Animal Models for CCNE2 Gene

MGI Knock Outs for CCNE2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNE2 Gene

Localization for CCNE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE2 Gene

Subcellular locations from

Jensen Localization Image for CCNE2 Gene COMPARTMENTS Subcellular localization image for CCNE2 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CCNE2 Gene

Pathways & Interactions for CCNE2 Gene

genes like me logo Genes that share pathways with CCNE2: view

Gene Ontology (GO) - Biological Process for CCNE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint TAS 9858585
GO:0000278 mitotic cell cycle TAS --
GO:0006270 DNA replication initiation IEA --
GO:0051301 cell division IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CCNE2: view

No data available for SIGNOR curated interactions for CCNE2 Gene

Drugs & Compounds for CCNE2 Gene

(1) Drugs for CCNE2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCNE2: view

Transcripts for CCNE2 Gene

Unigene Clusters for CCNE2 Gene

Cyclin E2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE2 Gene

No ASD Table

Relevant External Links for CCNE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNE2 Gene

mRNA expression in normal human tissues for CCNE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.1).

Protein differential expression in normal tissues from HIPED for CCNE2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNE2 Gene

SOURCE GeneReport for Unigene cluster for CCNE2 Gene Hs.521693

mRNA Expression by UniProt/SwissProt for CCNE2 Gene

Tissue specificity: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.
genes like me logo Genes that share expression patterns with CCNE2: view

Protein tissue co-expression partners for CCNE2 Gene

- Elite partner

Primer Products

Orthologs for CCNE2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCNE2 35
  • 94.55 (n)
  • 95.05 (a)
CCNE2 36
  • 95 (a)
(Canis familiaris)
Mammalia CCNE2 35
  • 92.93 (n)
  • 94.26 (a)
CCNE2 36
  • 96 (a)
(Mus musculus)
Mammalia Ccne2 35
  • 89.66 (n)
  • 92.31 (a)
Ccne2 16
Ccne2 36
  • 92 (a)
(Pan troglodytes)
Mammalia CCNE2 35
  • 99.01 (n)
  • 98.51 (a)
CCNE2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ccne2 35
  • 89.5 (n)
  • 93.05 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
-- 36
  • 69 (a)
-- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CCNE2 36
  • 85 (a)
(Gallus gallus)
Aves CCNE2 35
  • 74.64 (n)
  • 77.83 (a)
CCNE2 36
  • 76 (a)
(Anolis carolinensis)
Reptilia CCNE2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccne2 35
  • 66.5 (n)
  • 65.56 (a)
Str.20470 35
African clawed frog
(Xenopus laevis)
Amphibia ccne2-prov 35
(Danio rerio)
Actinopterygii ccne2 35
  • 62.27 (n)
  • 61.5 (a)
Dr.18081 35
ccne2 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycE 37
  • 40 (a)
CycE 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea cye-1 37
  • 31 (a)
cye-1 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB1 36
  • 17 (a)
CLB2 36
  • 16 (a)
CLB3 36
  • 17 (a)
CLB4 36
  • 13 (a)
CLB5 36
  • 16 (a)
CLB6 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for CCNE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNE2 Gene

Gene Tree for CCNE2 (if available)
Gene Tree for CCNE2 (if available)

Paralogs for CCNE2 Gene

Paralogs for CCNE2 Gene

(4) SIMAP similar genes for CCNE2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CCNE2: view

Variants for CCNE2 Gene

Sequence variations from dbSNP and Humsavar for CCNE2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs28399585 - 94,881,687(-) GTGCA(A/G)TGGAG reference, missense
rs2278891 -- 94,883,474(-) AATGT(C/T)CCTAT intron-variant, downstream-variant-500B
rs2467670 -- 94,883,878(+) ATTCT(C/G)TTTGT intron-variant, utr-variant-3-prime
rs7835501 -- 94,893,032(+) ATGGA(A/T)CTTTC intron-variant
rs9650134 -- 94,887,408(+) gctta(A/G)gcaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNE2 Gene

Variant ID Type Subtype PubMed ID
nsv6314 CNV Insertion 18451855
dgv7835n71 CNV Loss 21882294

Variation tolerance for CCNE2 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCNE2 Gene

Disorders for CCNE2 Gene

Relevant External Links for CCNE2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCNE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNE2 Gene

Publications for CCNE2 Gene

  1. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. (PMID: 9840927) Lauper N. … Amati B. (Oncogene 1998) 2 3 4 23 67
  2. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PMID: 9840943) Zariwala M. … Xiong Y. (Oncogene 1998) 2 3 23
  3. SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis. (PMID: 19084516) Klotz K. … Spruck C. (Exp. Cell Res. 2009) 3 23
  4. Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis. (PMID: 19107233) Wu Z. … Theodorescu D. (Neoplasia 2009) 3 23
  5. Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc. (PMID: 19564413) Caldon C.E. … Musgrove E.A. (Mol. Cell. Biol. 2009) 3 23

Products for CCNE2 Gene

Sources for CCNE2 Gene