CCNE1 Gene
protein-coding GIFtS: 67
GCID: GC19P030302
|
|
cyclin E1
(Previous symbol: CCNE)
| |
Aliases
for CCNE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cyclin E11 2 | | CCNE1 2 3 5 | | Cyclin Es2 | | Cyclin Et2 | | G1/S-Specific Cyclin-E12 |
Export aliases for CCNE1 gene to outside databasesPrevious GC identifers: GC19P030925 GC19P030751 GC19P034978 GC19P034994 GC19P026814 |
Summaries
for CCNE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCNE1:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by adramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordinationof each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activityis required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded ascells progress through S phase. Overexpression of this gene has been observed in many tumors, which results inchromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and beinvolved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates incell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in theabsence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have beendescribed. Two additional splice variants were reported but detailed nucleotide sequence information is not yetavailable. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864Function: Essential for the control of the cell cycle at the G1/S (start) transition
Gene Wiki entry for CCNE1 (Cyclin E1)
|
Genomic Views
for CCNE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCNE1 gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCNE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q12 Ensembl cytogenetic band: 19q12 HGNC cytogenetic band: 19q12CCNE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P030302: view genomic region
(about GC identifiers)
Start:
|
30,302,805 bp from pter |
End:
|
30,315,219 bp from pter |
Size:
|
12,415 bases |
Orientation:
|
plus strand |
|
Proteins
for CCNE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864 (See
protein sequence)Recommended Name: G1/S-specific cyclin-E1 Size: 410 amino acids; 47077 Da
Subunit: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex.The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (Bysimilarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interactionubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation
Subcellular location: Nucleus
1 PDB 3D structure from  and Proteopedia  for CCNE1:1W98 (3D)
Secondary accessions: A8K684 Q14091 Q8NFG1 Q92501 Q9UD21Alternative splicing: 3 isoforms: P24864-1 P24864-2 P24864-3 (Lacks 49 residues within the cyclin box and cannot complex with CDK2)Explore the universe of human proteins at neXtProt for CCNE1: NX_P24864
Post-translational modifications:
Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway1
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P24864
CCNE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001229.1
ENSEMBL proteins: ENSP00000262643 ENSP00000459024 ENSP00000410179 ENSP00000460881 ENSP00000350625 Reactome Protein details: P24864
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CCNE1 for ontologies About GeneDecksing
CCNE1 Antibody Products:
Assay Products for CCNE1: |
Protein
Domains /
Families
for CCNE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCNE1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P24864ProtoNet protein and cluster: P24864 1 Blocks protein family: IPB006670 Cyclin
UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864Similarity: Belongs to the cyclin family. Cyclin E subfamily |
Function
for CCNE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864Function: Essential for the control of the cell cycle at the G1/S (start) transition Genatlas biochemistry entry for CCNE1:cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed in many tumorsleading to a deregulated levels of protein and kinase activity relative to the cell cycle and inducing chromosomeinstability
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CCNE1 (NM_057182) | |  | Sino Biological Human cDNA Clone for CCNE1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCNE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
CCNE1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for CCNE1:
Animal Models:
Mouse knock-out Ccne1tm1Pisc for CCNE1
15/16 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Ccne1) (see all 16):
CCNE1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CCNE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/46 super-pathways (see all 46) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitinated Orc1 is degraded by the proteasome | | | 2 | Cell cycle_Cell cycle (generic schema) | | | 3 | G1/S-Specific Transcription | | | 4 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway | | | 5 | Cell cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 EMD Millipore Pathways for CCNE1 (see all 10)
5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNE1 (see all 15)
1 
Cell Signaling Technology (CST) Pathway for CCNE1
5/10  GeneGo (Thomson Reuters) Pathways for CCNE1 (see all 10)
5/20  BioSystems Pathways for CCNE1 (see all 20)
5/18 
Reactome Pathways for CCNE1 (see all 18)
5/7 
Kegg Pathways (Kegg details for CCNE1) (see all 7):
CCNE1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNE1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/134 Interacting proteins for CCNE1 (P248641, 2, 3 ENSP000002626434) via UniProtKB, MINT, STRING, and/or I2D (see all 134)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CDK2 | P249411, 2, 3, ENSP000002669704 | EBI-519526,EBI-375096 MINT-2983466 I2D:
score=10 STRING: ENSP00000266970 | | CDKN1B | P465271, 3, ENSP000002288724 | EBI-519526,EBI-519280 I2D:
score=3 STRING: ENSP00000228872 | | BRCA1 | P383981, 3, ENSP000003502834 | EBI-519526,EBI-349905 I2D:
score=2 STRING: ENSP00000350283 | | UHRF2 | Q96PU41, 3, ENSP000002768934 | EBI-519526,EBI-625304 I2D:
score=1 STRING: ENSP00000276893 | | FBXW7 | Q969H02, 3, ENSP000002817084 | MINT-15545 MINT-15544 MINT-14269 I2D:
score=5 STRING: ENSP00000281708 |
About this table
Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000079 | regulation of cyclin-dependent protein kinase activity |
IEA | -- | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000083 | regulation of transcription involved in G1/S phase of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- | | GO:0001547 | antral ovarian follicle growth |
-- | -- |
CCNE1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCNE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CCNE1 for compounds About GeneDecksing
 Browse Tocris compounds for CCNE1
4 Novoseek chemical compound relationships for CCNE1 gene About this table
Search CenterWatch for drugs/clinical trials and news about CCNE1
|
Transcripts
for CCNE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCNE1 gene (2 alternative transcripts): NM_001238.2 NM_057182.1 Unigene Cluster for CCNE1: Cyclin E1 Hs.244723 [show with all ESTs]Unigene Representative Sequence: NM_0012387 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262643(uc002nsn.3 uc002nso.3) ENST00000575243 ENST00000444983
ENST00000586912 ENST00000576532 ENST00000574121 ENST00000357943
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CCNE1 (NM_057182) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCNE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNE1 |
Additional cDNA sequence: AK291549.1 BC035498.2 M73812.1 M74093.1 8 DOTS entries: DT.100022532 DT.211154 DT.100720928 DT.100842149 DT.65284654 DT.100719142 DT.91966702 DT.121419930 24/82 AceView cDNA sequences (see all 82): M73812 BQ646961 CR601172 CR591189 BX360890 BM045770 NM_057182 NM_001238 BE887210 BQ653397 BM793183 BM047945 AW304866 BC035498 BX402709 CR593053 AW771831 BX361099 AA628312 BE544205 BX361098 BE867255 BG395682 BX350684
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CCNE1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCNE1
|
Expression
for CCNE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCNE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTCTGAAC
About this image
See CCNE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNE1
SOURCE GeneReport for Unigene cluster: Hs.244723
UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells
SABiosciences Expression via Pathway-Focused PCR Arrays including CCNE1 (see all 9):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCNE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE1 |
Orthologs
for CCNE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCNE1 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CCNE11 |
cyclin E1 |
74.42(n)
73.75(a) |
|
426117 NM_001031358.1 NP_001026529.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CCNE16 |
-- |
67(a) |
1 ↔ 1 |
GL343299.1(1576162-1586611) |
African clawed frog
(Xenopus laevis) |
Amphibia |
L43513.12 |
-- |
75.17(n) |
|
L43513.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC045842.12 |
-- |
74.76(n) |
|
30188 BC045842.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CycE1 , 3 |
G1/S transition of mitotic cell cycle
cyclin-dependent more3
Cyclin E1 |
43(a)3
52.43(n)1
49.34(a)1 |
|
35D43
349241 NM_165125.21 NP_723926.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
cye-11 , 3 |
Expression: seam cells, P lineage, VPC,
intestinal, more3
Protein CYE-11 |
31(a)3
47.57(n)1
33.58(a)1 |
|
I(6788885-6791944)3
1723991 NM_001025857.11 NP_001021028.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SDS6 |
cyclin-SDS |
9(a) |
possible ortholog |
1(5079407-5082520) |
rice
(Oryza sativa) |
Liliopsida |
-- |
cyclin, putative, expressed |
11(a) |
possible ortholog |
3(6555387-6561025) |
ENSEMBL Gene Tree for CCNE1 (if available)
TreeFam Gene Tree for CCNE1 (if available) |
Paralogs
for CCNE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCNE1 gene
- CCND32 CCNO2 CCNB22 CCNE22 CCNB32 CCNB12 CCND12 CCNA12
- CCND22 CCNA22
2 SIMAP similar genes for CCNE1 using alignment to 5 protein entries: CCNE1_HUMAN (see all proteins):CCNB1 CCNE2
CCNE1 for paralogs About GeneDecksing
|
Genomic Variants
for CCNE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCNE1 (30302805 - 30315219 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNE1: -- | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing CCNE1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNE1 |
|
Disorders
/ Diseases
for CCNE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCNE1 for disorders About GeneDecksing
OMIM gene information: 123837
OMIM disorders: --
20/71  diseases for CCNE1 (see all 71): About MalaCardsestrogen-receptor positive breast cancer diffuse large b-cell lymphoma facial dermatosis b-cell lymphomas
testicular germ cell tumor clear cell renal cell carcinoma endophthalmitis germ cell tumor
spindle cell sarcoma phlyctenulosis malignant peritoneal mesothelioma chronic endophthalmitis
urinary bladder cancer oral squamous cell carcinoma renal cell carcinoma clear cell adenocarcinoma
squamous cell carcinoma inflammatory bowel disease papillary thyroid carcinoma chronic lymphocytic leukemia
3 diseases from the University of Copenhagen DISEASES database for CCNE1:Facial dermatosis Phlyctenulosis Chronic endophthalmitis 10/15 Novoseek disease relationships for CCNE1 gene (see all 15) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoblastoma |
51.9 |
2 |
16949911 (1), 12674332 (1) |
| breast cancer |
44.7 |
21 |
19777567 (3), 16929516 (2), 16912169 (2), 16849587 (2) (see all 10) |
| cancer |
44.4 |
15 |
16808878 (4), 20180967 (3), 16912169 (2), 19084516 (2) (see all 7) |
| tumors |
35.9 |
26 |
12466974 (3), 16849587 (3), 11687642 (2), 10666388 (2) (see all 16) |
| ovarian cancer |
32.9 |
3 |
18281541 (2), 20336784 (1) |
| primary tumor |
32.5 |
1 |
11854029 (1) |
| bladder cancer |
30.1 |
4 |
10980118 (2), 18008359 (1) |
| carcinoma |
26.5 |
3 |
18047954 (1), 15770521 (1), 18008359 (1) |
| hepatocellular carcinoma |
14.9 |
1 |
19356046 (1) |
| lymphoma |
8.66 |
7 |
11291051 (4) |
Human Genome Epidemiology (HuGE) Navigator: CCNE1 (15 documents)
Export disorders for CCNE1 gene to outside databases
|
Publications
for CCNE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCNE1 gene, integrated from 9 sources (see all 362):
(articles sorted by number of sources associating them with CCNE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PubMed id 1833066)1, 2, 3 Lew D.J.... Reed S.I. (1991)
- Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. (PubMed id 8833152)1, 2, 9 Li H....Kidd V.J. (1996)
- Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PubMed id 9840943)1, 2, 9 Zariwala M.... Xiong Y. (1998)
- NIRF constitutes a nodal point in the cell cycle netw ork and is a candidate tumor suppressor. (PubMed id 21952639)1, 2 Mori T....Kochi H. (2011)
- NIRF induces G1 arrest and associates with Cdk2. (PubMed id 15178429)1, 2 Li Y.... Kochi H. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. (PubMed id 14536078)1, 2 Welcker M.... Roberts J.M. (2003)
- Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. (PubMed id 8861947)1, 2 Won K.A. and Reed S.I. (1996)
- Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. (PubMed id 8649818)1, 2 Geng Y.... Weinberg R.A. (1996)
- Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. (PubMed id 7739542)1, 2 Ohtsubo M.... Pagano M. (1995)
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External Searches for CCNE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CCNE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CCNE1 gene
(According to HUGE)
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Specialized Databases showing CCNE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for CCNE1 gene:
Search GeneIP for patents involving CCNE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CCNE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for CCNE1 | | OriGene shRNA RFP for CCNE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNE1 | | | OriGene Protein Over-expression Lysate for CCNE1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCNE1 | | OriGene 3'-UTR Clone for CCNE1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCNE1 | | OriGene Custom Protein Services for CCNE1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCNE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNE1 |
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| | Antibodies & Assays for CCNE1 |
| | | | Search Tocris compounds for CCNE1 |
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 | | | CCNE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE1 |
|  |  |  | | | | ThermoFisher Antibody for CCNE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNE1 |
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