Aliases for CCNE1 Gene
Aliases for CCNE1 Gene
External Ids for CCNE1 Gene
- HGNC: 1589
- Entrez Gene: 898
- Ensembl: ENSG00000105173
- OMIM: 123837
- UniProtKB: P24864
Previous HGNC Symbols for CCNE1 Gene
- CCNE
Previous GeneCards Identifiers for CCNE1 Gene
- GC19P030925
- GC19P030751
- GC19P034978
- GC19P034994
- GC19P030302
- GC19P026814
Summaries for CCNE1 Gene
-
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
-
Cyclin E, while currenly not as widely implicated as its cyclin D counterparts, has been implicated in various carcinomas, including breast, gastric, stomach and colorectal. High levels of cyclin E, either by gene amplification or overexpression, have been shown to lead to poorer prognosis in gastic carcinoma, and these measurements are correlated with later stage disease. In lung cancer, neoplastic cells with higher levels of the cyclin E/CDK2 complex are more radiosensitive than their more lowly expressed counterparts.
GeneCards Summary for CCNE1 Gene
CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Chronic Endophthalmitis and Facial Dermatosis. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Chaperonin-mediated protein folding. GO annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCNE2.
UniProtKB/Swiss-Prot for CCNE1 Gene
-
Essential for the control of the cell cycle at the G1/S (start) transition.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE1 Gene
Genomics for CCNE1 Gene
Regulatory Elements for CCNE1 Gene
Enhancers for CCNE1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19G029870 | 1.5 | Ensembl ENCODE dbSUPER | 18 | +61.4 | 61397 | 5.3 | ATF1 ZNF133 SIN3A ZNF121 GLIS2 GATA2 ELK1 ZNF143 ZNF207 KLF7 | CCNE1 URI1 ENSG00000267528 ENSG00000267433 |
| GH19G029836 | 0.8 | ENCODE | 30.1 | +25.5 | 25473 | 1.6 | PKNOX1 TBL1XR1 ZNF121 EGR1 ZNF207 RELB ETV6 IKZF2 CREM EGR2 | CCNE1 ENSG00000267433 |
| GH19G029804 | 1.1 | Ensembl ENCODE | 21.2 | -6.0 | -6019 | 3.6 | NFIB RARA CHAMP1 YY1 ZNF366 SCRT2 FOS EGR2 ZIK1 NFYC | CCNE1 ENSG00000266910 C19orf12 |
| GH19G029759 | 1.2 | Ensembl ENCODE | 17.8 | -51.6 | -51613 | 0.6 | PKNOX1 ARID4B SIN3A GLI4 ZNF2 ZNF48 ZNF121 GLIS2 ZNF143 ZNF207 | CCNE1 C19orf12 |
| GH19G029810 | 1.1 | ENCODE | 15.3 | -0.7 | -719 | 1.8 | HDGF PKNOX1 CREB3L1 SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 KLF13 | CCNE1 RPL9P32 ENSG00000266910 C19orf12 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCNE1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CCNE1 gene promoter:
Regulatory Element Products
Genomic Location for CCNE1 Gene
- Chromosome:
- 19
- Start:
- 29,811,898 bp from pter
- End:
- 29,824,312 bp from pter
- Size:
- 12,415 bases
- Orientation:
- Plus strand
Genomic View for CCNE1 Gene
Genes around CCNE1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q12 by Ensembl
- 19q12 by Entrez Gene
- 19q12 by HGNC
CCNE1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCNE1 Gene
Proteins for CCNE1 Gene
-
Protein details for CCNE1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24864-CCNE1_HUMAN
- Recommended name:
- G1/S-specific cyclin-E1
- Protein Accession:
- P24864
- A8K684
- Q14091
- Q8NFG1
- Q92501
- Q9UD21
Protein attributes for CCNE1 Gene
- Size:
- 410 amino acids
- Molecular mass:
- 47077 Da
- Quaternary structure:
-
- Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.
Protein Expression for CCNE1 Gene
Post-translational modifications for CCNE1 Gene
- Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
- Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CCNE1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CCNE1
- R&D Systems Antibodies for CCNE1 (Cyclin E1)
- Cell Signaling Technology (CST) Antibodies for CCNE1 (CCNE1)
-
Custom Antibody ServicesOriGene Antibodies for CCNE1
- AM05221PU-N
- AM32439PU-M
- AM32439PU-N
- AM32439PU-S
- TA590076
- TA353775
- TA353774
- TA336648
- TA333147
- TA325318
- TA325317
- TA325316
- TA325315
- TA321313
- TA321312
- TA311854
- TA311853
- TA311852
- TA311851
- R1000
- DM266-05
- DM266
- DM181-05
- DM181
- AP33174PU-S
- AP33174PU-N
- AP31751PU-N
- AP22705PU-N
- AP15512PU-S
- AP15512PU-N
- AP15512PU-M
- AP13251PU-N
- AP06082PU-N
- AP06081PU-N
- Novus Biologicals Antibodies for CCNE1
-
Abcam antibodies for CCNE1
- Invitrogen Antibodies for CCNE1
- antibodies-online Antibodies for CCNE1: See all 326
- GeneTex CCNE1 antibody for CCNE1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCNE1
Protein Products
-
OriGene Purified Proteins for CCNE1
- Search Origene for MassSpec and Protein Over-expression Lysates for CCNE1
- Origene Custom Protein Services for CCNE1
- Sino Biological Recombinant Proteins for CCNE1
- Sino Biological Cell Lysates for CCNE1
- antibodies-online Proteins for CCNE1: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CCNE1
-
Abcam proteins for CCNE1
Assay Products
- antibodies-online Kits for CCNE1: See all 26
No data available for DME Specific Peptides for CCNE1 Gene
Domains & Families for CCNE1 Gene
Gene Families for CCNE1 Gene
- HGNC:
Protein Domains for CCNE1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CCNE1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P24864- Family:
-
- Belongs to the cyclin family. Cyclin E subfamily.
Function for CCNE1 Gene
Molecular function for CCNE1 Gene
- GENATLAS Biochemistry:
- cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed in many tumors leading to a deregulated levels of protein and kinase activity relative to the cell cycle and inducing chromosome instability
- UniProtKB/Swiss-Prot Function:
- Essential for the control of the cell cycle at the G1/S (start) transition.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | NAS | 15572661 |
| GO:0005515 | protein binding | IPI | 8756624 |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | IEA | -- |
| GO:0019901 | protein kinase binding | IEA | -- |
Phenotypes for CCNE1 Gene
- MGI mutant phenotypes for CCNE1:
-
inferred from 5 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- cardiovascular system phenotype
- digestive/alimentary phenotype
- neoplasm
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for CCNE1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased G1 DNA content
- G0/1 arrest
- Increased HPV18 LCR reporter activity
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCNE1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCNE1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNE1 gene
- Search ViGene Biosciences for CCNE1
CRISPR Products
-
OriGene CRISPR knockouts for CCNE1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNE1
- GenScript: Design CRISPR guide RNA sequences for CCNE1
miRNA for CCNE1 Gene
- miRTarBase miRNAs that target CCNE1
-
- hsa-mir-15b-5p (MIRT000276)
- hsa-mir-503-5p (MIRT000646)
- hsa-mir-424-5p (MIRT000936)
- hsa-mir-16-5p (MIRT001226)
- hsa-mir-15a-5p (MIRT001228)
- hsa-mir-107 (MIRT004693)
- hsa-mir-185-5p (MIRT004698)
- hsa-mir-103a-3p (MIRT004762)
- hsa-mir-26b-5p (MIRT006308)
- hsa-mir-26a-5p (MIRT006309)
- hsa-mir-16-1-3p (MIRT006741)
- hsa-mir-195-5p (MIRT007237)
- hsa-mir-215-5p (MIRT024440)
- hsa-mir-192-5p (MIRT026235)
- hsa-mir-151a-3p (MIRT035523)
- hsa-mir-342-5p (MIRT038211)
- hsa-mir-125b-5p (MIRT045919)
- hsa-mir-92a-3p (MIRT049367)
- hsa-mir-383-3p (MIRT081648)
- hsa-mir-497-5p (MIRT081649)
- hsa-mir-4524a-5p (MIRT081651)
- hsa-mir-4694-3p (MIRT081652)
- hsa-mir-4524b-5p (MIRT081653)
- hsa-mir-6838-5p (MIRT081654)
- hsa-mir-7-5p (MIRT438133)
- hsa-mir-4477a (MIRT558884)
- hsa-mir-524-5p (MIRT558885)
- hsa-mir-520d-5p (MIRT558886)
- hsa-mir-5191 (MIRT558887)
- hsa-mir-646 (MIRT558888)
miRNA Products
- Search ViGene Biosciences for CCNE1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CCNE1
- Browse OriGene Inhibitory RNA Products For CCNE1
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNE1 gene
Clone Products
- Sino Biological Human cDNA Clone for CCNE1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CCNE1
- VectorBuilder custom plasmid, inducible vectors for CCNE1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCNE1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCNE1
-
ViGene Biosciences adenoviral particle packaged cDNA for CCNE1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCNE1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNE1 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-13418) for CCNE1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNE1 Gene
Localization for CCNE1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCNE1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IEA | -- |
| GO:0005634 | nucleus | IDA,IEA | 16109376 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0097134 | cyclin E1-CDK2 complex | IEA | -- |
Pathways & Interactions for CCNE1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.78
|
|
| 2 | Cyclins and Cell Cycle Regulation | ||
| 3 | Cell cycle Role of SCF complex in cell cycle regulation | ||
| 4 | DNA Damage Response | ||
| 5 | Chaperonin-mediated protein folding |
.94
|
|
Pathways by source for CCNE1 Gene
1 Sino Biological pathway for CCNE1 Gene
1 GeneTex pathway for CCNE1 Gene
1 Cell Signaling Technology pathway for CCNE1 Gene
20 BioSystems pathways for CCNE1 Gene
31 Reactome pathways for CCNE1 Gene
11 KEGG pathways for CCNE1 Gene
10 GeneGo (Thomson Reuters) pathways for CCNE1 Gene
1 R&D Systems pathway for CCNE1 Gene
Interacting Proteins for CCNE1 Gene
Selected Interacting proteins:
P24864-CCNE1_HUMAN
ENSP00000262643
for CCNE1 Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for CCNE1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | TAS | -- |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0000723 | telomere maintenance | IEA | -- |
| GO:0006270 | DNA replication initiation | IEA | -- |
Drugs & Compounds for CCNE1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Alisertib | Pharma | inhibitor, Biomarker | Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors | 0 | ||
| AMG900 | Pharma | Biomarker, inhibitor | AURKA Inhibitors, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors | 0 | ||
| BAY1000394 | Pharma | Inhibition, Biomarker | CDK4 Inhibitors, CDK2 Inhibitors | 0 | ||
| SCH727965 | Pharma | inhibitor, Biomarker | CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors | 0 |
Transcripts for CCNE1 Gene
mRNA/cDNA for CCNE1 Gene
- (6) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (82) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CCNE1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCNE1
- GenScript: Design CRISPR guide RNA sequences for CCNE1
miRNA Products
- Search ViGene Biosciences for CCNE1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CCNE1
- Browse OriGene Inhibitory RNA Products For CCNE1
-
ViGene Biosciences ready-to-package AAV shRNAs for CCNE1 gene
Clone Products
- Sino Biological Human cDNA Clone for CCNE1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CCNE1
- VectorBuilder custom plasmid, inducible vectors for CCNE1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCNE1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-13418) for CCNE1
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||
| SP4: |
Expression for CCNE1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for CCNE1 Gene
This gene is overexpressed in Testis (x4.8).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCNE1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CCNE1 Gene:
CCNE1SOURCE GeneReport for Unigene cluster for CCNE1 Gene:
Hs.244723mRNA Expression by UniProt/SwissProt for CCNE1 Gene:
P24864-CCNE1_HUMAN
Tissue specificity:
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Evidence on tissue expression from TISSUES for CCNE1 Gene
- Liver(2.3)
- Stomach(2.3)
- Intestine(2.1)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for CCNE1
-
OriGene qPCR primer pairs and template standards for CCNE1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNE1 Gene
Orthologs for CCNE1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCNE1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CCNE1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CCNE1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccne1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccne1 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCNE1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CCNE1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCNE1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CCNE1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccne1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ccne1 34 35 |
|
||
| -- 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3561 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CycE 36 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cye-1 36 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CLB6 35 |
|
ManyToMany | |
| CLB1 35 |
|
ManyToMany | |||
| CLB2 35 |
|
ManyToMany | |||
| CLB3 35 |
|
ManyToMany | |||
| CLB5 35 |
|
ManyToMany | |||
| CLB4 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.14750 34 |
|
- Species where no ortholog for CCNE1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CCNE1 Gene
Paralogs for CCNE1 Gene
(2) SIMAP similar genes for CCNE1 Gene using alignment to 7 proteins:
Variants for CCNE1 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000345404 | -- | 29,811,839(+) | GGGGC(A/G)GGTCC | upstream-variant-2KB | |
| rs1000514115 | -- | 29,824,675(+) | CTCAG(A/G)TGATC | downstream-variant-500B | |
| rs1000522945 | -- | 29,818,350(+) | GAAAC(-/G)GGGGT | intron-variant | |
| rs1000533643 | -- | 29,812,899(+) | AGCTT(C/T)CTCTT | intron-variant | |
| rs1000621456 | -- | 29,824,626(+) | TGGAG(A/G)TGGGG | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1035e212 | CNV | loss | 25503493 |
| esv274862 | CNV | loss | 21479260 |
| nsv1072344 | CNV | deletion | 25765185 |
| nsv1121975 | CNV | deletion | 24896259 |
| nsv1126519 | CNV | deletion | 24896259 |
| nsv1133066 | OTHER | inversion | 24896259 |
| nsv2456 | CNV | deletion | 18451855 |
| nsv828517 | CNV | gain | 20364138 |
| nsv828518 | CNV | loss | 20364138 |
| nsv833800 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.14;
23.12% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCNE1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE1 Gene
Disorders for CCNE1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic endophthalmitis |
|
|
| facial dermatosis |
|
|
| phlyctenulosis |
|
|
| bowenoid papulosis |
|
|
| lung adenoma |
|
|
Search CCNE1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CCNE1
No data available for UniProtKB/Swiss-Prot and Genatlas for CCNE1 Gene
Publications for CCNE1 Gene
- Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PMID: 19258477) Goode E.L. … Sellers T.A. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 22 46 64
- Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver K.E. … Dunning A.M. (Carcinogenesis 2008) 3 22 46 64
- Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PMID: 18281541) Song H. … Gayther S.A. (Clin. Cancer Res. 2008) 3 22 46 64
- Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PMID: 18507837) Azzato E.M. … Pharoah P.D. (Breast Cancer Res. 2008) 3 22 46 64
- Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PMID: 17409409) Gayther S.A. … Pharoah P.D. (Cancer Res. 2007) 3 22 46 64
Products for CCNE1 Gene
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- antibodies-online Antibodies for CCNE1: See all 326
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- Mammalian expression: PiggyBac
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- Yeast expression
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