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CCNE1 Gene

protein-coding   GIFtS: 66

GC19P034994
cyclin E1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CCNE)
Services    

Aliases &
Descriptions
for CCNE1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CCNE 2, 3
Descriptions
cyclin E1 2
cyclin Es 2
cyclin Et 2
External Ids
HGNC: 15891
Entrez Gene: 8982
UniProtKB: P248643
Ensembl: ENSG000001051737
Search outside databases for aliases for CCNE1 gene

Previous GC identifers: GC19P030925 GC19P030751 GC19P034978

Summaries
for CCNE1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for CCNE1:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are
characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins
function as regulators of CDK kinases. Different cyclins exhibit distinct expression and
degradation patterns which contribute to the temporal coordination of each mitotic event. This
cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is
required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and
is degraded as cells progress through S phase. Overexpression of this gene has been observed in
many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.
This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein
(nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene
expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have
been described. Two additional splice variants were reported but detailed nucleotide sequence
information is not yet available. [provided by RefSeq]

UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864
Function: Essential for the control of the cell cycle at the G1/S (start) transition

Gene Wiki entry for CCNE1 (Cyclin_E1)

Genomic Location
for CCNE1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CCNE1 gene  

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q12   HGNC cytogenetic band: 19q12

CCNE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P034994:     (about GC identifiers)

Start:
 34,994,741 bp from pter
End:
 35,007,059 bp from pter
Size:
 12,319 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  

Proteins
for CCNE1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864 (See protein sequence)
Recommended Name: G1/S-specific cyclin-E1  
Size: 410 amino acids; 47077 Da
Subunit: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase
holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts
with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with
CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1
Subcellular location: Nucleus
PDB structures from and Proteopedia :
1W98 (3D)    
Secondary accessions: A8K684 Q14091 Q8NFG1 Q92501 Q9UD21
Alternative splicing: 3 isoforms:  P24864-1   P24864-2   P24864-3   

Post-translational modifications:

  • Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin
    proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001229.1  NP_476530.1  


    ENSEMBL proteins: 
    ENSP00000262643 ENSP00000350625 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CCNE1
    Recombinant Proteins from Abcam (Cyclin E)
    Human Recombinant Proteins from Abnova (CCNE1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS--
    GO:0005654 nucleoplasm EXP7629134 10454565
    GO:0005829 cytosol EXP7799941 11907280
    About this table

    Antibodies for CCNE1: 
    Invitrogen Antibodies for CCNE1
    Millipore Mono- and Polyclonal Antibodies for the study of CCNE1
    Sigma-Aldrich Antibodies for CCNE1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CCNE1  (CycE Kinase)
    Antibodies from Abcam (Cyclin E), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (CCNE1)
    Novus Biologicals Antibodies for CCNE1

    Assays for CCNE1: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of CCNE1
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for CCNE1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro domains/families:
     IPR006670 Cyclin
     IPR013763 Cyclin_related
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C
     IPR014400 Cyclin_A_B_D_E


       GeneDecks  CCNE1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P24864

    ProtoNet protein and cluster: P24864

    1 Blocks protein family: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864
    Similarity: Belongs to the cyclin family. Cyclin E subfamily

    Gene Function
    for CCNE1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CCNE1)
    Millipore RNAi Products for the Analysis of CCNE1 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (CCNE1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001238

                  Applied Biosystems Silencer® siRNAs for CCNE1

                  Sigma-Aldrich siRNA and siRNA Panels for CCNE1  
                         Sigma-Aldrich shRNA Panels and shRNA for CCNE1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for CCNE1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001238
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001238
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001238 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001238

    UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864
    Function: Essential for the control of the cell cycle at the G1/S (start) transition

    Genatlas biochemistry entry for CCNE1:
    cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed
    in many tumors leading to a deregulated levels of protein and kinase activity relative to the cell
    cycle and inducing chromosome instability

    14 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ccne1):

    cellulardigestive/alimentaryembryogenesisendocrine/exocrine gland
    growth/sizehematopoietic systemimmune systemlethality-prenatal/perinatallife span-post-weaning/aging
    normalreproductive systemskeletontumorigenesis

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713 transcription coactivator activity NAS15572661
    GO:0005515 protein binding IPI9891079
    GO:0050681 androgen receptor binding NAS15572661
    About this table

    Pathways & Interactions
    for CCNE1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5 Invitrogen iPath™ Online BioAtlas - Pathways for CCNE1 (Maps provided by GeneGo):
     Cdc25 regulation of cell cycle
     Opioid and somatostatin systems in negative cell growth regulation via MAP kinase pathways
     ATM/ATR regulation of G1/S checkpoint
     Regulatory cascade of cyclin gene expression
     Regulation of G1-S transition

       GeneDecks  CCNE1 for the pathways selected above  
    About GeneDecksing

    5/10 Millipore Pathways for CCNE1 (see all 10 )
     DNA damage ATM/ATR regulation of G1/S checkpoint
     Cell cycle Regulation of G1/S transition (part 2)
     Cell cycle Regulation of G1/S transition (part 1)
     Cell cycle Start of DNA replication in early S phase
     Cell cycle ESR1 regulation of G1/S transition

       GeneDecks  CCNE1 for the pathways selected above  
    About GeneDecksing

    5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for  CCNE1  (Your Favorite Gene powered by Ingenuity) (see all 7 ) 
     Factors Promoting Cardiogenesis in Vertebrates
     Small Cell Lung Cancer Signaling
     Cell Cycle Regulation by BTG Family Proteins
     Molecular Mechanisms of Cancer
     Prostate Cancer Signaling

       GeneDecks  CCNE1 for the pathways selected above  
    About GeneDecksing

    5 Kegg Pathways  (Kegg details for CCNE1):
     hsa04110 Cell cycle
     hsa04115 p53 signaling pathway
     hsa05200 Pathways in cancer
     hsa05215 Prostate cancer
     hsa05222 Small cell lung cancer

       GeneDecks  CCNE1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  CCNE1 


    5/80 Interacting proteins for CCNE1 (P248641, 2 ENSP000002626433) via UniProtKB, MINT, and/or STRING (see all 80 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXW7Q969H02, ENSP000002817083MINT-15545 MINT-15544 MINT-14269 STRING (score=.999)
    CDKN1BP465271, ENSP000002288723EBI-519526, EBI-519280 STRING (score=.999)
    BRCA1P383981, ENSP000003502833EBI-519526, EBI-349905 STRING (score=.972)
    CDK2P249411, 2, ENSP000002669703EBI-519526, EBI-375096 MINT-2983466 EBI-519526, EBI-375096 MINT-2983466 STRING (score=.999)
    CDKN1AP389361, 2EBI-519526, EBI-375077 MINT-2635177 EBI-519526, EBI-375077 MINT-2635177
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082 G1/S transition of mitotic cell cycle NAS8207080
    GO:0007049 cell cycle IEA--
    GO:0030521 androgen receptor signaling pathway NAS15572661
    GO:0045893 positive regulation of transcription, DNA-dependent NAS15572661
    GO:0051301 cell division IEA--
    About this table

    Drugs & Compounds
    for CCNE1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for CCNE1
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for CCNE1
    2 Novoseek chemical compound relationships for CCNE1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 0.06 1 17371803 (1)
    calcium 0.00 1 16969097 (1)
    About this table


    Transcripts
    for CCNE1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CCNE1)
    Millipore RNAi Products for the Analysis of CCNE1 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (CCNE1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001238

                  Sigma-Aldrich siRNA and siRNA Panels for CCNE1  
                         Sigma-Aldrich shRNA Panels and shRNA for CCNE1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001238  NM_057182  

    REFSEQ mRNAs for CCNE1 gene (2 alternative transcripts): 

    NM_001238.1   NM_057182.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001238  NM_057182  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001238
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001238
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001238 

    Additional cDNA sequence: 

    AK291549.1 BC035498.2 CR591189.1 CR593053.1 CR601172.1 M73812.1 M74093.1 

    8 DOTS entries:

    DT.100022532  DT.211154  DT.100720928  DT.121419930  DT.100842149  DT.65284654  DT.100719142  DT.91966702 

    24/82 AceView cDNA sequences (see all 82 ):

    BM793183 NM_001238 CR591189 BX361099 AW771831 BX402709 BC035498 NM_057182 
    AW304866 CR593053 BQ653397 CR601172 BE887210 BM047945 BM045770 BX360890 
    BQ646961 M73812 BF980611 M74093 BE544205 BQ018270 AU156110 BF980866 

    highest scoring ESTs for CCNE1:

    M73812 AA570076 AA592960 AA628312 AI186210 AI671049 AU135533 AU156110 AU157314 AW300786 

    Unigene Cluster for CCNE1:

    Cyclin E1
    Hs.244723  [show with all ESTs]
    Unigene Representative Sequence: BC035498


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CCNE1

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:              -                       -                                                                     
    SP2:                                      -                                                                     
    SP3:                                                                                                            
    SP4:                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for CCNE1

    2 Ensembl transcripts including schematic representations:
    ENST00000262643  ENST00000357943  

    Expression
    for CCNE1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CCNE1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CCNE1

    1 / 2 / 3

    4 probe-sets matching CCNE1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		2021_s_at2, 3 U95-A 1 1.00 1.00 0.87 0.81 M73812 1.00 1.00 1.00 1
    41060_at2, 3 U95-A 1 1.00 1.00 0.95 1.20 M73812 1.00 1.00 1.00 1

    		213523_at2, 3 U133-A 1 1.00 1.00 -- -- AI671049 0.80 1.00 0.91 1

    		213523_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  CCNE1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTGTCTGAAC

    SOURCE GeneReport for Unigene cluster: Hs.244723

    Expression variation in blood from EXPOLDB for CCNE1

    UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864
    Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial
    cells

    Orthologs
    for CCNE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for CCNE1 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 CCNE11   -- cyclin E1 86.6(n)
    86.6(a)    		 484610  XM_541724.2  XP_541724.2 
    chimpanzee
    (Pan troglodytes)    		 CCNE11   -- cyclin E1 99.91(n)
    99.74(a)    		 455914  XM_512559.2  XP_512559.2 
    cow
    (Bos taurus)    		 CCNE11   -- cyclin E1 88.4(n)
    85.93(a)    		 533526  XM_612960.3  XP_612960.3 
    rat
    (Rattus norvegicus)    		 Ccne11   -- cyclin E1 79.41(n)
    80.15(a)    		 25729  XM_574426.2  XP_574426.2 
    mouse
    (Mus musculus)    		 Ccne11, 5 7 (16.00 cM)5
    		 cyclin E11, 5 79.32(n)1
    79.65(a)1    		 124471  NM_007633.21  NP_031659.21 
     AA4378685  AK0899505  (see all 19)
    About this table        Species with no ortholog for CCNE1

    ENSEMBL Gene Tree for CCNE1

    Paralogs
    for CCNE1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CCNE1 gene
    CCNE22  

    SNPs/Variants
    for CCNE1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/142 NCBI SNPs in CCNE1 are shown (see all 142 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 29)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs14061,2
    		A,C,F,H35006952(-) AGAGGG/TCAGCC 2 -- ut31 ese36Minor allele frequency- T:0.35NS MN EU EA WA 720
    rs32180761,2
    		C,F,H35007110(+) TTTAAT/GTGTGG 2 -- ng3117Minor allele frequency- G:0.44NS EU EA WA NA 1582
    --
    rs32180261,2
    		C,F34994978(+) gggtgC/Aggccg 2 -- int1 ng511Minor allele frequency- A:0.36NS 168
    rs72573301,2
    		F,H34993663(+) GGGTGG/AGGGAT 2 -- ng514Minor allele frequency- A:0.16EU EA WA 416
    --
    rs32180731,2
    		F35006856(+) TGGCTC/TTCCTC 2 -- ut31 ese31Minor allele frequency- T:0.12NS 116
    --
    rs129731031,2
    		A35007167(+) TCTTTC/Tttttt 2 -- ng310--------
    --
    rs32180251,2
    		F34994823(+) TCCCGGCGCCGCCGCCG
    CCACTGCCGT    /-    CGCCG     		2 -- ng51 ut511Minor allele frequency- -:0.09NS 174
    --
    rs32180281,2
    		F34995225(+) AAGGGG/-TACTG 2 -- int1 ng51 trp31Minor allele frequency- -:0.18NS 170
    --
    rs32180751,2
    		F35007070(+) TTTTAT/CGAGCT 2 -- ng311Minor allele frequency- C:0.02NS 114
    --
    rs32180271,2
    		F34995192(+) CTggcT/Ccgccc 2 -- ng51 int11Minor allele frequency- C:0.13NS 178
    About this table

    HapMap Linkage Disequilibrium images for CCNE1 (up to first 250kb)

    Disorders & Mutations
    for CCNE1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 123837

    10/15 Novoseek disease relationships for CCNE1 gene (see all 15 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 47.99 2 16949911 (1), 12674332 (1)
    cancer 39.60 10 16808878 (4), 16912169 (2), 15166955 (1), 18507837 (1) (see all 5)
    breast cancer 36.50 17 16929516 (2), 16912169 (2), 16849587 (2), 12466974 (1) (see all 8)
    primary tumor 35.89 1 11854029 (1)
    tumors 33.61 22 12466974 (3), 16849587 (3), 11687642 (2), 10666388 (2) (see all 14)
    ovarian cancer 31.86 2 18281541 (2)
    carcinoma 27.01 3 18047954 (1), 15770521 (1), 18008359 (1)
    bladder cancer 26.84 4 10980118 (2), 18008359 (1)
    hepatocellular carcinoma 18.90 1 19356046 (1)
    gastric cancer 8.80 2 10666388 (2)
    About this table

    Human Genome Epidemiology Navigator: CCNE1 (8 documents)

    Medical News
    for CCNE1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for CCNE1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/212 PubMed articles for CCNE1 gene (see all 212 ):

    Search for CCNE1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCNE1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 898 HGNC: 1589 AceView: CCNE1 Ensembl:ENSG00000105173 euGenes: HUgn898
    ECgene: CCNE1 H-InvDB: CCNE1

    Other Databases showing CCNE1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing CCNE1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CCNE1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccne1/

    Licensable Technologies
    for CCNE1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for CCNE1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CCNE1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for CCNE1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for CCNE1 Antibodies for CCNE1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CCNE1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (CCNE1)
     Antibodies (CCNE1)
     Chimera RNAi (CCNE1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Antibodies & Assays for CCNE1  (CycE Kinase)

     Recombinant Proteins
    (Cyclin E)
     Antibodies (Cyclin E)
     Search OriGene for CCNE1
     Search Tocris compounds for CCNE1




     Drugs/Proteins for CCNE1
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for CCNE1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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