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CCNE1 Gene

protein-coding   GIFtS: 68
GCID: GC19P030302

Cyclin E1


(Previous symbol: CCNE)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin E11 2     Cyclin E Variant Ex5del2
CCNE1 2 3 5     Cyclin E Variant Ex7del2
Cyclin Es1 2     G1/S-Specific Cyclin-E12
Cyclin Et1 2     

External Ids:    HGNC: 15891   Entrez Gene: 8982   Ensembl: ENSG000001051737   OMIM: 1238375   UniProtKB: P248643   

Export aliases for CCNE1 gene to outside databases

Previous GC identifers: GC19P030925 GC19P030751 GC19P034978 GC19P034994 GC19P026814


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNE1 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase
boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many
tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found
to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM
locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting
cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which
encode distinct isoforms, have been described. Two additional splice variants were reported but detailed
nucleotide sequence information is not yet available. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNE1 Gene:
CCNE1 (cyclin E1) is a protein-coding gene. Diseases associated with CCNE1 include phlyctenulosis, and facial dermatosis. GO annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCND3.

UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864
Function: Essential for the control of the cell cycle at the G1/S (start) transition

Gene Wiki entry for CCNE1 (Cyclin E1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNE1 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNE1 promoter sequence
   Search Chromatin IP Primers for CCNE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q12   Ensembl cytogenetic band:  19q12   HGNC cytogenetic band: 19q12

CCNE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNE1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P030302:  view genomic region     (about GC identifiers)

Start:
30,302,805 bp from pter      End:
30,315,215 bp from pter
Size:
12,411 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864 (See protein sequence)
Recommended Name: G1/S-specific cyclin-E1  
Size: 410 amino acids; 47077 Da
Subunit: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme
complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1
and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2;
the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation
1 PDB 3D structure from and Proteopedia for CCNE1:
1W98 (3D)    
Secondary accessions: A8K684 Q14091 Q8NFG1 Q92501 Q9UD21
Alternative splicing: 3 isoforms:  P24864-1   P24864-2   P24864-3   (Lacks 49 residues within the cyclin box and cannot complex with CDK2)

Explore the universe of human proteins at neXtProt for CCNE1: NX_P24864

Explore proteomics data for CCNE1 at MOPED

Post-translational modifications: 

  • Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7,
    and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low
    affinity degron also recognized by FBXW71
  • Ubiquitinated by UHRF2; appears to occur independently of phosphorylation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCNE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001229.1  
    ENSEMBL proteins: 
     ENSP00000262643   ENSP00000459024   ENSP00000410179   ENSP00000460881   ENSP00000350625  
    Reactome Protein details: P24864

    CCNE1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCNE1
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    OriGene Custom Protein Services for CCNE1
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    Novus Biologicals CCNE1 Proteins
    Novus Biologicals CCNE1 Lysates
    Sino Biological Recombinant Protein for CCNE1
    Sino Biological Cell Lysate for CCNE1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CCNE1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNE1
    R&D Systems Antibodies for CCNE1 (Cyclin E1)
    Cell Signaling Technology (CST) Antibodies for CCNE1 
    OriGene Antibodies for CCNE1
    OriGene Custom Antibody Services for CCNE1
    Novus Biologicals CCNE1 Antibodies
    Abcam antibodies for CCNE1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CCNE1
    LSBio Antibodies in human, mouse, rat for CCNE1

    CCNE1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCNE1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCNE1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028858 Cyclin_E
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P24864

    ProtoNet protein and cluster: P24864

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864
    Similarity: Belongs to the cyclin family. Cyclin E subfamily


    CCNE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNE1_HUMAN, P24864
    Function: Essential for the control of the cell cycle at the G1/S (start) transition

         Genatlas biochemistry entry for CCNE1:
    cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed in many tumors
    leading to a deregulated levels of protein and kinase activity relative to the cell cycle and inducing chromosome
    instability

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0005515protein binding IPI10330164
    GO:0016301kinase activity IEA--
    GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity IEA--
    GO:0019901protein kinase binding IEA--
         
    CCNE1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CCNE1:
     Decreased number of cells in m  G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a 

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ccne1) (see all 16):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system  integument 
     mortality/aging  nervous system  normal  reproductive system  skeleton 

    CCNE1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccne1tm1Pisc for CCNE1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCNE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCNE1:
    hsa-mir-15b-5p (MIRT000276), hsa-mir-503-5p (MIRT000646), hsa-mir-107 (MIRT004693), hsa-mir-26b-5p (MIRT006308), hsa-mir-15a-5p (MIRT001228), hsa-mir-151a-3p (MIRT035523), hsa-mir-192-5p (MIRT026235), hsa-mir-103a-3p (MIRT004762), hsa-mir-125b-5p (MIRT045919), hsa-mir-215-5p (MIRT024440), hsa-mir-26a-5p (MIRT006309), hsa-mir-92a-3p (MIRT049367), hsa-mir-424-5p (MIRT000936), hsa-mir-185-5p (MIRT004698), hsa-mir-342-5p (MIRT038211), hsa-mir-16-5p (MIRT001226), hsa-mir-195-5p (MIRT007237)

    Block miRNA regulation of human, mouse, rat CCNE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNE1 (see all 10):
    hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-646 hsa-miR-103a hsa-miR-424 hsa-miR-16 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidCCNE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCNE1
    Predesigned siRNA for gene silencing in human, mouse, rat CCNE1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCNE1

    Clone
    Products:
         
    OriGene clones in human, mouse for CCNE1 (see all 12)
    OriGene ORF clones in mouse, rat for CCNE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCNE1 (NM_057182)
    Sino Biological Human cDNA Clone for CCNE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNE1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CCNE1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCNE1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNE1_HUMAN, P24864: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    CCNE1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNE1 About   (see all 50)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    p53-Dependent G1/S DNA damage checkpoint0.92
    Cyclin A-Cdk2-associated events at S phase entry0.85
    p53-Dependent G1 DNA Damage Response0.92
    S Phase0.78
    G1/S DNA Damage Checkpoints0.87
    Cell Cycle Checkpoints0.58
    SCF(Skp2)-mediated degradation of p27/p210.86
    Parkinson's Disease Pathway0.31
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    G1/S-Specific Transcription0.00
    G1 to S cell cycle control0.35
    3Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cell Cycle Control by BTG Proteins0.36
    G1-S Phase Transition0.67
    Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes0.00
    4Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    5Cell cycle
    Cell cycle0.59
    Cell cycle0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNE1 (see all 15)
        Cell Cycle Control by BTG Proteins
    Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics
    TOB in T-Cell Signaling

    1 Cell Signaling Technology (CST) Pathway for CCNE1
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CCNE1 (see all 10)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation

    Selected BioSystems Pathways for CCNE1 (see all 20)
        Cell cycle
    DNA damage response
    G1 to S cell cycle control
    miRNAs involved in DDR
    Parkin-Ubiquitin Proteasomal System pathway

    1 Sino Biological Pathway for CCNE1
        p53 Pathway

    Selected Reactome Pathways for CCNE1 (see all 8)
        SCF(Skp2)-mediated degradation of p27/p21
    G0 and Early G1
    Cyclin E associated events during G1/S transition
    Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
    E2F mediated regulation of DNA replication


    Selected Kegg Pathways  (Kegg details for CCNE1) (see all 11):
        Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Hepatitis B


    CCNE1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNE1 (see all 9): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNE1 (P248641, 2, 3 ENSP000002626434) via UniProtKB, MINT, STRING, and/or I2D (see all 309)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-519526,EBI-375077 MINT-2635177 I2D: score=5 STRING: ENSP00000244741
    CDKN1BP465271, 3, ENSP000002288724EBI-519526,EBI-519280 I2D: score=3 STRING: ENSP00000228872
    BRCA1P383981, 3, ENSP000003502834EBI-519526,EBI-349905 I2D: score=2 STRING: ENSP00000350283
    UHRF2Q96PU41, 3, ENSP000002768934EBI-519526,EBI-625304 I2D: score=1 STRING: ENSP00000276893
    FBXW7Q969H02, 3, ENSP000002817084MINT-15545 MINT-15544 MINT-14269 I2D: score=5 STRING: ENSP00000281708
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006270DNA replication initiation IEA--

    CCNE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNE1

    4 Novoseek inferred chemical compound relationships for CCNE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 29.5 10 19564413 (2), 17371803 (1), 16929516 (1), 16755028 (1) (see all 5)
    calcium 0 1 16969097 (1)
    progesterone 0 1 17371803 (1)
    serine 0 1 16038965 (1)



    CCNE1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCNE1 gene (2 alternative transcripts): 
    NM_001238.2  NM_057182.1  

    Unigene Cluster for CCNE1:

    Cyclin E1
    Hs.244723  [show with all ESTs]
    Unigene Representative Sequence: NM_001238
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262643(uc002nsn.3 uc002nso.3) ENST00000575243 ENST00000444983
    ENST00000586912 ENST00000576532 ENST00000574121 ENST00000357943
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCNE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNE1 (see all 10):
    hsa-miR-15a hsa-miR-503 hsa-miR-497 hsa-miR-646 hsa-miR-103a hsa-miR-424 hsa-miR-16 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidCCNE1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCNE1
    Predesigned siRNA for gene silencing in human, mouse, rat CCNE1
    Clone
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    OriGene clones in human, mouse for CCNE1 (see all 12)
    OriGene ORF clones in mouse, rat for CCNE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCNE1 (NM_057182)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNE1
    Primer
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    OriGene qPCR primer pairs and template standards for CCNE1
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNE1
      QuantiTect SYBR Green Assays in human, mouse, rat CCNE1
      QuantiFast Probe-based Assays in human, mouse, rat CCNE1

    Additional mRNA sequence: 

    AK291549.1 BC035498.2 M73812.1 M74093.1 

    8 DOTS entries:

    DT.100022532  DT.211154  DT.100720928  DT.100842149  DT.65284654  DT.100719142  DT.91966702  DT.121419930 

    Selected AceView cDNA sequences (see all 82):

    BC035498 M73812 BM045770 CR591189 NM_001238 BQ646961 AW771831 BM793183 
    AW304866 CR601172 BX360890 NM_057182 BQ653397 BX402709 BE887210 BX361099 
    BM047945 CR593053 BG395682 BX372891 BX350684 W95471 BF980611 BE744187 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CCNE1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
    SP1:              -                       -                                                                     
    SP2:                                      -                                                                     
    SP3:                                                                                                            
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for CCNE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCNE1 expression in normal human tissues (normalized intensities)      CCNE1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTCTGAAC
    CCNE1 Expression
    About this image


    CCNE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Placenta (Extraembryonic Tissues)
    CCNE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.244723

    UniProtKB/Swiss-Prot: CCNE1_HUMAN, P24864
    Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNE1 (see all 9): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CCNE1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccne11 , 5 cyclin E11, 5 79.32(n)1
    79.65(a)1
      7 (25.35 cM)5
    124471  NM_007633.21  NP_031659.21 
     380979845 
    chicken
    (Gallus gallus)
    Aves CCNE11 cyclin E1 74.42(n)
    73.75(a)
      426117  NM_001031358.1  NP_001026529.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNE16
    cyclin E1
    66(a)
    1 ↔ 1
    GL343299.1(1574534-1585991)
    African clawed frog
    (Xenopus laevis)
    Amphibia L43513.12   -- 75.17(n)    L43513.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045842.12   -- 74.76(n)   30188  BC045842.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycE1 , 3 G1/S transition of mitotic cell cycle
    cyclin-dependent more3
    Cyclin E1
    43(a)3
    52.43(n)1
    49.34(a)1
      35D43
    349241  NM_057612.41  NP_476960.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cye-13 Expression: seam cells, P lineage, VPC,
    intestinal, more
    31(a)   I(6788885-6791944)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLB66
    CLB16
    (see all 6)
    B-type cyclin involved in DNA replication during S...
    B-type cyclin involved in cell cycle progression; ...
    (see all 6)
    18(a)
    17(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    VII(705359-706501) YGR109C
    VII(703636-705051) YGR108W


    ENSEMBL Gene Tree for CCNE1 (if available)
    TreeFam Gene Tree for CCNE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNE1 gene
    CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  
    2 SIMAP similar genes for CCNE1 using alignment to 7 protein entries:     CCNE1_HUMAN (see all proteins):
    CCNB1    CCNE2

    CCNE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNE1 (see all 368)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1855966401,2
    --30301123(+) TTTTGG/TAAACA 1 -- us2k10--------
    rs1901189241,2
    --30301179(+) GGGGGA/GTTCAG 1 -- us2k10--------
    rs1382432601,2
    --30301275(+) TAAGAA/CCCTGG 1 -- us2k10--------
    rs1816498201,2
    --30301284(+) GGCTCC/TAACTT 1 -- us2k10--------
    rs362253991,2
    C--30301288(+) CTAAC-/TTCAAG 1 -- us2k10--------
    rs1430334651,2
    --30301380(+) TTTACA/GCACAT 1 -- us2k10--------
    rs1443997921,2
    --30301493(+) CTTTCA/CAATGT 1 -- us2k10--------
    rs362253981,2
    C,F--30301535(+) GTCCAG/AGCACT 1 -- us2k13Minor allele frequency- A:0.04WA EA 240
    rs1487599321,2
    --30301541(+) GCACTA/CTGCCA 1 -- us2k10--------
    rs1424066971,2
    --30301609(+) CAGAGA/GGGCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNE1 (30302805 - 30315215 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CCNE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274862CNV Loss21479260
    nsv833800CNV Loss17160897
    nsv2456CNV Loss18451855
    nsv828518CNV Loss20364138
    nsv828517CNV Gain20364138

    Human Gene Mutation Database (HGMD): CCNE1
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing CCNE1:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing CCNE1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123837    OMIM disorders: --

    Selected diseases for CCNE1 (see all 70):    About MalaCards
    phlyctenulosis    facial dermatosis    chronic endophthalmitis    spindle cell sarcoma
    malignant peritoneal mesothelioma    endophthalmitis    polyploidy    primary mediastinal large b-cell lymphoma
    estrogen-receptor positive breast cancer    clear cell adenocarcinoma    mediastinitis    diffuse large b-cell lymphoma
    peritonitis    familial breast cancer    clear cell renal cell carcinoma    retinoblastoma
    testicular germ cell tumor    b-cell lymphomas    ovarian cancer    gastric adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for CCNE1:
    Facial dermatosis     Phlyctenulosis     Chronic endophthalmitis

    CCNE1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CCNE1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 51.9 2 16949911 (1), 12674332 (1)
    breast cancer 44.7 21 19777567 (3), 16929516 (2), 16912169 (2), 16849587 (2) (see all 10)
    cancer 44.4 15 16808878 (4), 20180967 (3), 16912169 (2), 19084516 (2) (see all 7)
    tumors 35.9 26 12466974 (3), 16849587 (3), 11687642 (2), 10666388 (2) (see all 16)
    ovarian cancer 32.9 3 18281541 (2), 20336784 (1)
    primary tumor 32.5 1 11854029 (1)
    bladder cancer 30.1 4 10980118 (2), 18008359 (1)
    carcinoma 26.5 3 18047954 (1), 15770521 (1), 18008359 (1)
    hepatocellular carcinoma 14.9 1 19356046 (1)
    lymphoma 8.66 7 11291051 (4)

    Genetic Association Database (GAD): CCNE1
    Human Genome Epidemiology (HuGE) Navigator: CCNE1 (15 documents)

    Export disorders for CCNE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNE1 gene, integrated from 10 sources (see all 405):
    (articles sorted by number of sources associating them with CCNE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PubMed id 1833066)1, 2, 3 Lew D.J.... Reed S.I. (Cell 1991)
    2. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PubMed id 18281541)1, 4, 9 Song H....Gayther S.A. (Clin. Cancer Res. 2008)
    3. Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. (PubMed id 8833152)1, 2, 9 Li H....Kidd V.J. (Genomics 1996)
    4. The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. (PubMed id 15660127)1, 2, 9 Honda R....Johnson L.N. (EMBO J. 2005)
    5. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PubMed id 9840943)1, 2, 9 Zariwala M.... Xiong Y. (Oncogene 1998)
    6. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PubMed id 19258477)1, 4, 9 Goode E.L....Sellers T.A. (amp 2009)
    7. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PubMed id 18174243)1, 4, 9 Driver K.E....Dunning A.M. (Carcinogenesis 2008)
    8. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (Breast Cancer Res. 2008)
    9. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PubMed id 17409409)1, 4, 9 Gayther S.A....Pharoah P.D. (Cancer Res. 2007)
    10. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 898 HGNC: 1589 AceView: CCNE1 Ensembl:ENSG00000105173 euGenes: HUgn898
    ECgene: CCNE1 Kegg: 898 H-InvDB: CCNE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNE1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccne1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNE1 gene:
    Search GeneIP for patents involving CCNE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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