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Aliases for CCNDBP1 Gene

Aliases for CCNDBP1 Gene

  • Cyclin D-Type Binding-Protein 1 2 3
  • GCIP 3 4 6
  • Grap2 And Cyclin-D-Interacting Protein 3 4
  • D-Type Cyclin-Interacting Protein 1 2 3
  • Human Homolog Of Maid 3 4
  • DIP1 3 4
  • HHM 3 4
  • Grap2 Cyclin Interacting Protein 2
  • Cyclin-D1-Binding Protein 1 3
  • MAID Protein 2
  • HHM Protein 2

External Ids for CCNDBP1 Gene

Previous GeneCards Identifiers for CCNDBP1 Gene

  • GC15P038845
  • GC15P036373
  • GC15P041057
  • GC15P041193
  • GC15P041264
  • GC15P043477
  • GC15P020326

Summaries for CCNDBP1 Gene

Entrez Gene Summary for CCNDBP1 Gene

  • This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for CCNDBP1 Gene

CCNDBP1 (Cyclin D-Type Binding-Protein 1) is a Protein Coding gene. Diseases associated with CCNDBP1 include optic disk drusen.

UniProtKB/Swiss-Prot for CCNDBP1 Gene

  • May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.

Gene Wiki entry for CCNDBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNDBP1 Gene

Genomics for CCNDBP1 Gene

Regulatory Elements for CCNDBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNDBP1 Gene

Start:
43,185,118 bp from pter
End:
43,197,177 bp from pter
Size:
12,060 bases
Orientation:
Plus strand

Genomic View for CCNDBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNDBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNDBP1 Gene

Proteins for CCNDBP1 Gene

  • Protein details for CCNDBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95273-CCDB1_HUMAN
    Recommended name:
    Cyclin-D1-binding protein 1
    Protein Accession:
    O95273
    Secondary Accessions:
    • A8K3Q0
    • A8K3U2
    • Q6ZQN9
    • Q7Z519
    • Q8NBS7
    • Q8NBY2
    • Q9NS19
    • Q9NYH3
    • Q9UHX9

    Protein attributes for CCNDBP1 Gene

    Size:
    360 amino acids
    Molecular mass:
    40262 Da
    Quaternary structure:
    • Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.
    SequenceCaution:
    • Sequence=AAD11777.1; Type=Frameshift; Positions=8, 14, 18; Evidence={ECO:0000305}; Sequence=AAP97163.1; Type=Frameshift; Positions=17, 40; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCNDBP1 Gene

    Alternative splice isoforms for CCNDBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNDBP1 Gene

Proteomics data for CCNDBP1 Gene at MOPED

Post-translational modifications for CCNDBP1 Gene

No data available for DME Specific Peptides for CCNDBP1 Gene

Domains for CCNDBP1 Gene

Protein Domains for CCNDBP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95273

UniProtKB/Swiss-Prot:

CCDB1_HUMAN :
  • O95273
Family:
  • Belongs to the CCNDBP1 family.
genes like me logo Genes that share domains with CCNDBP1: view

No data available for Gene Families for CCNDBP1 Gene

Function for CCNDBP1 Gene

Molecular function for CCNDBP1 Gene

UniProtKB/Swiss-Prot Function: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
UniProtKB/Swiss-Prot Induction: Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation.

Gene Ontology (GO) - Molecular Function for CCNDBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10915743
genes like me logo Genes that share ontologies with CCNDBP1: view
genes like me logo Genes that share phenotypes with CCNDBP1: view

Animal Models for CCNDBP1 Gene

MGI Knock Outs for CCNDBP1:

Animal Model Products

CRISPR Products

miRNA for CCNDBP1 Gene

miRTarBase miRNAs that target CCNDBP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCNDBP1 Gene

Localization for CCNDBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNDBP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNDBP1 Gene COMPARTMENTS Subcellular localization image for CCNDBP1 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCNDBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12437976
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCNDBP1: view

Pathways for CCNDBP1 Gene

SuperPathways for CCNDBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCNDBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CCNDBP1: view

No data available for Pathways by source for CCNDBP1 Gene

Compounds for CCNDBP1 Gene

(1) HMDB Compounds for CCNDBP1 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with CCNDBP1: view

Transcripts for CCNDBP1 Gene

Unigene Clusters for CCNDBP1 Gene

Cyclin D-type binding-protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNDBP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNDBP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: - - -
SP11:
SP12: - - - -
SP13: - - -
SP14:
SP15: - - - -

ExUns: 10a · 10b ^ 11
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CCNDBP1 Gene

GeneLoc Exon Structure for
CCNDBP1
ECgene alternative splicing isoforms for
CCNDBP1

Expression for CCNDBP1 Gene

mRNA expression in normal human tissues for CCNDBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNDBP1 Gene

This gene is overexpressed in Whole Blood (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNDBP1 Gene

SOURCE GeneReport for Unigene cluster for CCNDBP1 Gene Hs.36794

mRNA Expression by UniProt/SwissProt for CCNDBP1 Gene

O95273-CCDB1_HUMAN
Tissue specificity: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
genes like me logo Genes that share expressions with CCNDBP1: view

In Situ Assay Products

Orthologs for CCNDBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCNDBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNDBP1 35
  • 99.44 (n)
  • 98.89 (a)
CCNDBP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNDBP1 35
  • 87.92 (n)
  • 83.15 (a)
CCNDBP1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNDBP1 35
  • 86.94 (n)
  • 83.89 (a)
CCNDBP1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccndbp1 35
  • 84.2 (n)
  • 82.37 (a)
Ccndbp1 16
Ccndbp1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNDBP1 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccndbp1 35
  • 83.96 (n)
  • 79.42 (a)
chicken
(Gallus gallus)
Aves CCNDBP1 35
  • 61.37 (n)
  • 53.21 (a)
CCNDBP1 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNDBP1 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccndbp1 35
  • 58.51 (n)
  • 51.07 (a)
zebrafish
(Danio rerio)
Actinopterygii CCNDBP1 36
  • 38 (a)
OneToOne
zgc:162082 35
  • 54.57 (n)
  • 42.68 (a)
Species with no ortholog for CCNDBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNDBP1 Gene

ENSEMBL:
Gene Tree for CCNDBP1 (if available)
TreeFam:
Gene Tree for CCNDBP1 (if available)

Paralogs for CCNDBP1 Gene

No data available for Paralogs for CCNDBP1 Gene

Variants for CCNDBP1 Gene

Sequence variations from dbSNP and Humsavar for CCNDBP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs15064 -- 43,195,115(-) GAGAA(A/T)AAGGC utr-variant-3-prime, nc-transcript-variant
rs487584 -- 43,189,103(+) AAAAA(A/G)GAAAG intron-variant
rs495286 -- 43,191,339(-) AGGCG(A/G)GGCCT intron-variant
rs513071 -- 43,186,599(+) CTAGA(A/G)TTTAA intron-variant
rs530118 -- 43,186,313(+) TTGCA(C/T)GCACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNDBP1 Gene

Variant ID Type Subtype PubMed ID
nsv525461 CNV Loss 19592680
dgv2368n71 CNV Loss 21882294

Relevant External Links for CCNDBP1 Gene

HapMap Linkage Disequilibrium report
CCNDBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNDBP1 Gene

Disorders for CCNDBP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CCNDBP1 Gene including...

Search for CCNDBP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CCNDBP1 Gene

genes like me logo Genes that share disorders with CCNDBP1: view

No data available for UniProtKB/Swiss-Prot for CCNDBP1 Gene

Publications for CCNDBP1 Gene

  1. GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. (PMID: 10801854) Xia C. … Liu M. (J. Biol. Chem. 2000) 2 3 4 23
  2. GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis. (PMID: 17131381) Ma W. … Liu M. (J. Cell. Biochem. 2007) 3 4 23
  3. Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells. (PMID: 17621266) Chang T.-W. … Chang M.-C. (Oncogene 2008) 3 4 23
  4. Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model. (PMID: 17532760) Chellas-GAcry B. … Fields K.A. (Cell. Microbiol. 2007) 3 23
  5. Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins. (PMID: 10854051) Yao Y. … Weinstein I.B. (Exp. Cell Res. 2000) 3 4

Products for CCNDBP1 Gene

Sources for CCNDBP1 Gene

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