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CCNDBP1 Gene

protein-coding   GIFtS: 52
GCID: GC15P043477

Cyclin D-Type Binding-Protein 1

  See CCNDBP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin D-Type Binding-Protein 11 2     HHM2 3
GCIP2 3 5     Grap2 Cyclin Interacting Protein1
D-Type Cyclin-Interacting Protein 11 2     HHM Protein1
Grap2 And Cyclin-D-Interacting Protein2 3     MAID Protein1
Human Homolog Of Maid2 3     Cyclin-D1-Binding Protein 12
DIP12 3     

External Ids:    HGNC: 15871   Entrez Gene: 235822   Ensembl: ENSG000001669467   OMIM: 6070895   UniProtKB: O952733   

Export aliases for CCNDBP1 gene to outside databases

Previous GC identifers: GC15P038845 GC15P036373 GC15P041057 GC15P041193 GC15P041264 GC15P020326


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNDBP1 Gene:
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein
important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D.
Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin
D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to
interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene
expression. Several alternatively spliced variants have been found for this gene. (provided by RefSeq, Apr 2009)

GeneCards Summary for CCNDBP1 Gene:
CCNDBP1 (cyclin D-type binding-protein 1) is a protein-coding gene. Diseases associated with CCNDBP1 include optic disk drusen, and congenital dyserythropoietic anemia type i.

UniProtKB/Swiss-Prot: CCDB1_HUMAN, O95273
Function: May negatively regulate cell cycle progression. May act at least in part via inhibition of the
cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription

Gene Wiki entry for CCNDBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNDBP1 gene promoter:
         STAT5B   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNDBP1 promoter sequence
   Search Chromatin IP Primers for CCNDBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNDBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14-q15   Ensembl cytogenetic band:  15q15.2   HGNC cytogenetic band: 15q14-q15

CCNDBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNDBP1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P043477:  view genomic region     (about GC identifiers)

Start:
43,477,316 bp from pter      End:
43,488,229 bp from pter
Size:
10,914 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCDB1_HUMAN, O95273 (See protein sequence)
Recommended Name: Cyclin-D1-binding protein 1  
Size: 360 amino acids; 40262 Da
Subunit: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3
Developmental stage: Expression may increase during differentiation
Sequence caution: Sequence=AAD11777.1; Type=Frameshift; Positions=8, 14, 18; Sequence=AAP97163.1; Type=Frameshift;
Positions=17, 40;
1 PDB 3D structure from and Proteopedia for CCNDBP1:
3AY5 (3D)    
Secondary accessions: A8K3Q0 A8K3U2 Q6ZQN9 Q7Z519 Q8NBS7 Q8NBY2 Q9NS19 Q9NYH3 Q9UHX9
Alternative splicing: 4 isoforms:  O95273-1   O95273-2   O95273-3   O95273-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCNDBP1: NX_O95273

Explore proteomics data for CCNDBP1 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Ubiquitination2 at Lys170, Lys179
  • Modification sites at PhosphoSitePlus

  • See CCNDBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036274.3  
    ENSEMBL proteins: 
     ENSP00000300213   ENSP00000456797   ENSP00000456839   ENSP00000455687   ENSP00000457611  
     ENSP00000456041   ENSP00000455419   ENSP00000454420   ENSP00000349047  

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    antibodies-online proteins for CCNDBP1 (8 products) 

     
    antibodies-online peptides for CCNDBP1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026907 CCNDBP1

    Graphical View of Domain Structure for InterPro Entry O95273

    ProtoNet protein and cluster: O95273

    UniProtKB/Swiss-Prot: CCDB1_HUMAN, O95273
    Similarity: Belongs to the CCNDBP1 family


    Find genes that share domains with CCNDBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCDB1_HUMAN, O95273
    Function: May negatively regulate cell cycle progression. May act at least in part via inhibition of the
    cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription
    Induction: Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10915743
         
    Find genes that share ontologies with CCNDBP1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccndbp1):
     behavior/neurological  cellular  embryogenesis  liver/biliary system  tumorigenesis 

    Find genes that share phenotypes with CCNDBP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccndbp1tm1Drmr for CCNDBP1

       genOway: Develop your customized and physiologically relevant rodent model for CCNDBP1

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    miRTarBase miRNAs that target CCNDBP1:
    hsa-mir-26b-5p (MIRT030350), hsa-mir-9-5p (MIRT021474), hsa-mir-3615 (MIRT052851)

    Block miRNA regulation of human, mouse, rat CCNDBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNDBP1 (see all 12):
    hsa-miR-136 hsa-miR-1179 hsa-miR-3921 hsa-miR-340 hsa-miR-3144-3p hsa-miR-3922-3p hsa-miR-4287 hsa-miR-9
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCDB1_HUMAN, O95273: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CCNDBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCNDBP1
    Interactions:

        GeneGlobe Interaction Network for CCNDBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for CCNDBP1 (O952731, 2, 3 ENSP000003002134) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ID2Q023631, 2EBI-748961,EBI-713450 MINT-8396328 MINT-8396313 MINT-8396281 MINT-8396356
    COPS5Q929051, 3, ENSP000003505124EBI-748961,EBI-594661 I2D: score=1 STRING: ENSP00000350512
    CCND1P243852, 3, ENSP000002275074MINT-8396267 I2D: score=2 STRING: ENSP00000227507
    OLIG1Q8TAK62, 3, ENSP000003310664MINT-8396226 I2D: score=1 STRING: ENSP00000331066
    MRPS9P829332, 3, ENSP000002584554MINT-64674 I2D: score=4 STRING: ENSP00000258455
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0051726regulation of cell cycle ----

    Find genes that share ontologies with CCNDBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNDBP1 (CCDB1)

    1 HMDB Compound for CCNDBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNDBP1 gene (2 alternative transcripts): 
    NM_012142.4  NM_037370.2  

    Unigene Cluster for CCNDBP1:

    Cyclin D-type binding-protein 1
    Hs.36794  [show with all ESTs]
    Unigene Representative Sequence: NM_012142
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564630(uc021sjs.1) ENST00000300213(uc001zqv.3 uc010udl.2 uc021sjt.1 uc010bdb.3)
    ENST00000566515 ENST00000569745 ENST00000563065 ENST00000567434 ENST00000566833
    ENST00000568507 ENST00000565296(uc021sju.1) ENST00000562553 ENST00000567690
    ENST00000444658(uc001zqy.3) ENST00000566882 ENST00000568936 ENST00000565958
    ENST00000356633
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    hsa-miR-136 hsa-miR-1179 hsa-miR-3921 hsa-miR-340 hsa-miR-3144-3p hsa-miR-3922-3p hsa-miR-4287 hsa-miR-9
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      QuantiTect SYBR Green Assays in human, mouse, rat CCNDBP1
      QuantiFast Probe-based Assays in human, mouse, rat CCNDBP1

    Additional mRNA sequence: 

    AF082569.1 AF087852.1 AF132034.1 AF246144.1 AK225143.1 AK225645.1 AK290665.1 AK290707.1 
    AK295017.1 BC009689.1 CR450331.1 NR_027513.2 NR_027514.2 NR_045998.1 NR_045999.1 

    Selected DOTS entries (see all 25):

    DT.92443948  DT.100828950  DT.100828948  DT.100829729  DT.100751104  DT.95147136  DT.100828952  DT.100801128 
    DT.100654188  DT.100828946  DT.116592  DT.121051238  DT.101976190  DT.429308  DT.101983802  DT.95147142 
    DT.100828940  DT.100828949  DT.100761380  DT.100828938  DT.100828945  DT.91823930  DT.92443947  DT.95147148 

    Selected AceView cDNA sequences (see all 344):

    CA427361 BM768556 BM666400 CR622678 BX357085 BQ014620 CR623865 AA386027 
    CR616591 BI793217 CR598585 CR623091 CA414891 BG328129 BG469516 BX365544 
    H88096 AA993010 CA450112 AA862628 CB106950 AI990446 AK124193 BU740620 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCNDBP1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ^
    SP1:                          -           -     -           -                 -                                                                             -   
    SP2:                          -           -     -           -                 -                                                                             -   
    SP3:                                                        -                 -                                                                             -   
    SP4:                          -           -     -     -     -                 -                                                                                 
    SP5:                          -           -     -           -                 -     -     -                                                                     

    ExUns: 10a · 10b ^ 11
    SP1:  -               
    SP2:                  
    SP3:  -               
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CCNDBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNDBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCTCATT
    CCNDBP1 Expression
    About this image


    CCNDBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thyroid (Endocrine System)
     
     Adrenal Gland (Endocrine System)
     
     Placenta (Extraembryonic Tissues)
    CCNDBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNDBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.36794

    UniProtKB/Swiss-Prot: CCDB1_HUMAN, O95273
    Tissue specificity: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including
    breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNDBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCNDBP1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccndbp11 , 5 cyclin D-type binding-protein 11, 5 84.2(n)1
    82.37(a)1
      2 (60.37 cM)5
    171511  NM_010761.21  NP_034891.21 
     1210084035 
    chicken
    (Gallus gallus)
    Aves CCNDBP11 cyclin D-type binding-protein 1 61.37(n)
    53.21(a)
      419217  XM_417394.4  XP_417394.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNDBP16
    cyclin D-type binding-protein 1
    43(a)
    1 ↔ 1
    GL343820.1(35886-46041)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX853508.12   -- 76.06(n)    BX853508.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1620821 zgc:162082 54.57(n)
    42.68(a)
      553373  NM_001089365.1  NP_001082834.1 


    ENSEMBL Gene Tree for CCNDBP1 (if available)
    TreeFam Gene Tree for CCNDBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNDBP1 (see all 266)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833381081,2
    --43477938(+) GCCGGA/GCTTGG 5 -- int10--------
    rs2021033441,2
    C--43478036(+) GGAGAC/G/TCACCG 10 T S I mis1 int10--------
    rs3696289391,2
    C--43478095(+) CCTTCC/TGGGCT 5 -- int10--------
    rs1419439081,2
    C--43478109(+) CTTGCC/TTCAGT 5 -- int10--------
    rs5405871,2
    C,F,A,H--43478113(+) CCTCAC/GTTCCT 5 -- int121Minor allele frequency- G:0.25NS EA NA MN WA CSA 2520
    rs2009728431,2
    C--43478119(+) TTCCTC/TCAGCG 5 -- int10--------
    rs1888459491,2
    --43478151(+) CTGTCC/TCCCAC 5 -- int10--------
    rs10782431,2
    C--43478156(-) CCTCCC/GTGGGG 5 -- int14Minor allele frequency- G:0.49NA MN CSA WA 306
    rs797521411,2
    C,F--43478170(+) CTGCTC/TTCCCC 5 -- int13Minor allele frequency- T:0.08CSA WA 122
    rs1458964621,2
    C--43478207(+) TACCCA/GCCTCA 5 -- int10--------

    HapMap Linkage Disequilibrium report for CCNDBP1 (43477316 - 43488229 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCNDBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2368n71CNV Loss21882294
    nsv525461CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNDBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNDBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607089    OMIM disorders: --

    2 diseases for CCNDBP1:    
    About MalaCards
    optic disk drusen    congenital dyserythropoietic anemia type i

    1 disease from the University of Copenhagen DISEASES database for CCNDBP1:
    Optic disk drusen

    Find genes that share disorders with CCNDBP1           About GenesLikeMe


    Export disorders for CCNDBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNDBP1 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with CCNDBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. (PubMed id 10801854)1, 2, 3, 9 Xia C.... Liu M. (J. Biol. Chem. 2000)
    2. GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis. (PubMed id 17131381)1, 2, 9 Ma W.... Liu M. (J. Cell. Biochem. 2007)
    3. Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells. (PubMed id 17621266)1, 2, 9 Chang T.-W....Chang M.-C. (Oncogene 2008)
    4. Human homologue of maid is a useful marker protein in hepatocarcinogenesis. (PubMed id 15887118)1, 2 Takami T.... Okita K. (Gastroenterology 2005)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    6. Human homologue of maid: a dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression. (PubMed id 10915743)1, 2 Terai S.... Thorgeirsson S.S. (Hepatology 2000)
    7. p29, a novel GCIP-interacting protein, localizes in the nucleus. (PubMed id 11118353)1, 2 Chang M.-S.... Yang Y.-C. (Biochem. Biophys. Res. Commun. 2000)
    8. Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins. (PubMed id 10854051)1, 2 Yao Y....Weinstein I.B. (Exp. Cell Res. 2000)
    9. Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model. (PubMed id 17532760)1, 9 Chellas-GAcry B....Fields K.A. (Cell. Microbiol. 2007)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23582 HGNC: 1587 AceView: CCNDBP1 Ensembl:ENSG00000166946 euGenes: HUgn23582
    ECgene: CCNDBP1 H-InvDB: CCNDBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNDBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNDBP1 gene:
    Search GeneIP for patents involving CCNDBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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