Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCND3 Gene

protein-coding   GIFtS: 72
GCID: GC06M041949

Cyclin D3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin D31 2
D3-Type Cyclin2
G1/S-Specific Cyclin D32
G1/S-Specific Cyclin-D32

External Ids:    HGNC: 15851   Entrez Gene: 8962   Ensembl: ENSG000001125767   OMIM: 1238345   UniProtKB: P302813   

Export aliases for CCND3 gene to outside databases

Previous GC identifers: GC06M041904 GC06M042010 GC06M041621


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCND3 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact
with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with
this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV
radiation. Several transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Oct 2008)

GeneCards Summary for CCND3 Gene: 
CCND3 (cyclin D3) is a protein-coding gene. Diseases associated with CCND3 include bladder carcinoma in situ, and plasma cell leukemia, and among its related super-pathways are Signal transduction AKT signaling and G1-S Phase Transition. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCND3_HUMAN, P30281
Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the
retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for
nuclear translocation and activity of the cyclin D-CDK4 complex

Gene Wiki entry for CCND3 (Cyclin D3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCND3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCND3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCND3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCND3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21

CCND3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCND3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041949:  view genomic region     (about GC identifiers)

Start:
41,902,671 bp from pter      End:
42,018,095 bp from pter
Size:
115,425 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCND3_HUMAN, P30281 (See protein sequence)
Recommended Name: G1/S-specific cyclin-D3  
Size: 292 amino acids; 32520 Da
Subunit: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex.
The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K.
Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of
CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A
Subcellular location: Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear
membrane and are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity)
1 PDB 3D structure from and Proteopedia for CCND3:
3G33 (3D)    
Secondary accessions: B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49
Alternative splicing: 4 isoforms:  P30281-1   P30281-2   P30281-3   P30281-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCND3: NX_P30281

Explore proteomics data for CCND3 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30281

  • CCND3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCND3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001129489.1  NP_001129597.1  NP_001129598.1  NP_001751.1  

    ENSEMBL proteins: 
     ENSP00000362082   ENSP00000426212   ENSP00000362078   ENSP00000401595   ENSP00000362079  
     ENSP00000397545   ENSP00000425986   ENSP00000421511   ENSP00000423242   ENSP00000425830  
     ENSP00000425334   ENSP00000420991  
    Reactome Protein details: P30281
    Human Recombinant Protein Products for CCND3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCND3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCND3
    GenScript Custom Purified and Recombinant Proteins Services for CCND3
    Novus Biologicals CCND3 Proteins
    Novus Biologicals CCND3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCND3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA8114739
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    CCND3 for ontologies           About GeneDecksing



    CCND3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCND3 (Cyclin D3)
    Cell Signaling Technology (CST) Antibodies for CCND3 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCND3
    GenScript Custom Superior Antibodies Services for CCND3
    Novus Biologicals CCND3 Antibodies
    Abcam antibodies for CCND3
    Cloud-Clone Corp. Antibodies for CCND3 
    ThermoFisher Antibody for CCND3
    LSBio Antibodies in human, mouse, rat for CCND3 

    Assay Products for CCND3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCND3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCND3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCND3 
    Cloud-Clone Corp. CLIAs for CCND3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P30281

    ProtoNet protein and cluster: P30281

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCND3_HUMAN, P30281
    Similarity: Belongs to the cyclin family. Cyclin D subfamily
    Similarity: Contains 1 cyclin N-terminal domain


    CCND3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCND3_HUMAN, P30281
    Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the
    retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
    Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
    subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
    Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
    and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
    repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for
    nuclear translocation and activity of the cyclin D-CDK4 complex

         Genatlas biochemistry entry for CCND3:
    cyclin D3,regulator of progression through G1 phase during the cell cycle 3,33/34kDa,overexpressed with CDKN1B in
    agressive B cell lymphomas and in glioblastoma and gliosarcoma,involved in the loss of cell cycle control in a
    small fraction of malignant gliomas

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0005515protein binding IPI11896535
    GO:0019901protein kinase binding IPI8114739
         
    CCND3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCND3:
     Increased cell number in G1, s 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccnd3):
     behavior/neurological  cardiovascular system  cellular  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  normal 
     respiratory system  tumorigenesis  vision/eye 

    CCND3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccnd3tm1Pisc for CCND3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCND3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCND3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCND3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCND3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCND3:
    hsa-mir-34a (MIRT001010), hsa-mir-424 (MIRT000937), hsa-mir-16 (MIRT000940)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCND3
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate CCND3 (see all 32):
    hsa-miR-642a hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-424 hsa-miR-409-5p hsa-miR-124 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCND3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCND3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCND3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCND3
    Sirion Biotech Customized adenovirus for overexpression of CCND3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCND3 (see all 19)
    OriGene ORF clones in mouse, rat for CCND3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCND3 (NM_001136017)
    Sino Biological Human cDNA Clone for CCND3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCND3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND3
    Sirion Biotech Customized lentivirus for stable overexpression of CCND3 
                         Customized lentivirus expression plasmids for stable overexpression of CCND3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCND3
    Search LifeMap BioReagents cell lines for CCND3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCND3 About   (see all 33)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.32
    3Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for CCND3 (see all 9)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Regulation of G1/S transition (part 2)
    Cytoskeleton remodeling FAK signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Signal transduction AKT signaling

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCND3 (see all 9)
        G1-S Phase Transition
    Breast Cancer Regulation by Stathmin1
    Cyclins and Cell Cycle Regulation
    IL-10 Pathway
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for CCND3
        Cell Cycle / Checkpoint Control

    5/9 GeneGo (Thomson Reuters) Pathways for CCND3 (see all 9)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Signal transduction AKT signaling
    Development IGF-1 receptor signaling
    Cell cycle Cell cycle (generic schema)

    5/14 BioSystems Pathways for CCND3 (see all 14)
        DNA damage response
    Focal Adhesion
    Cell cycle
    Wnt Signaling Pathway
    G1 to S cell cycle control


    5        Reactome Pathways for CCND3
        G1 Phase
    Mitotic G1-G1/S phases
    Cell Cycle
    Cell Cycle, Mitotic
    Cyclin D associated events in G1


    5/10         Kegg Pathways  (Kegg details for CCND3) (see all 10):
        Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Wnt signaling pathway
    Hippo signaling pathway


    CCND3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCND3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for CCND3 (P302811, 2, 3 ENSP000003620824) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCM10Q7L5902, 3MINT-50440 I2D: score=5 
    EIF3KQ9UBQ52, 3, ENSP000002483424MINT-50583 MINT-50582 MINT-50584 I2D: score=3 STRING: ENSP00000248342
    CDK4P118021, 2, 3, ENSP000002579044EBI-375013,EBI-295644 MINT-50438 I2D: score=10 STRING: ENSP00000257904
    CDK6Q005341, 2, 3, ENSP000002657344EBI-375013,EBI-295663 MINT-50439 I2D: score=8 STRING: ENSP00000265734
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-375013,EBI-375077 MINT-50441 I2D: score=7 STRING: ENSP00000244741
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ----
    GO:0001934positive regulation of protein phosphorylation IDA8114739
    GO:0007165signal transduction IEA--
    GO:0042098T cell proliferation IEA--
    GO:0045737positive regulation of cyclin-dependent protein kinase activity IDA8114739

    CCND3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCND3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCND3

    10/38 Novoseek inferred chemical compound relationships for CCND3 gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 41 22 15131122 (5), 16985050 (4), 12393642 (1), 10849422 (1) (see all 7)
    retinoic acid 38.4 27 16920920 (4), 16024653 (4), 12482873 (4), 17209053 (2) (see all 9)
    betulinic acid 31 6 19102935 (3), 19107355 (3)
    sulforaphane 29 3 12530531 (2), 15033759 (1)
    butyrate 24.8 5 10716680 (2), 11029587 (1), 14526425 (1)
    rottlerin 24.4 2 17407153 (1), 16959960 (1)
    curcumin 21 3 12674762 (2), 12483537 (1)
    phosphatidylinositol 19.1 2 16815849 (2)
    silymarin 16.1 1 16322307 (1)
    ly294002 15.8 1 16267832 (1)

    Search CenterWatch for drugs/clinical trials and news about CCND3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCND3 gene (4 alternative transcripts): 
    NM_001136017.2  NM_001136125.1  NM_001136126.1  NM_001760.3  

    Unigene Cluster for CCND3:

    Cyclin D3
    Hs.534307  [show with all ESTs]
    Unigene Representative Sequence: AL833425
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000372991(uc003orn.3 uc003oro.3) ENST00000511642 ENST00000372987(uc003orm.3)
    ENST00000415497(uc011duk.2) ENST00000372988(uc003orp.3) ENST00000414200
    ENST00000510503 ENST00000511686 ENST00000512426 ENST00000513956 ENST00000506555
    ENST00000508143 ENST00000505064 ENST00000510058(uc011dul.1) ENST00000505672(uc011dum.1)
    ENST00000511161 ENST00000505884 ENST00000514382
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCND3
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate CCND3 (see all 32):
    hsa-miR-642a hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-424 hsa-miR-409-5p hsa-miR-124 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCND3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCND3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCND3
    Clone
    Products:
         
    OriGene clones in human, mouse for CCND3 (see all 19)
    OriGene ORF clones in mouse, rat for CCND3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCND3 (NM_001136017)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCND3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND3
    Sirion Biotech Customized lentivirus for stable overexpression of CCND3 
                         Customized lentivirus expression plasmids for stable overexpression of CCND3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCND3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCND3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCND3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCND3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCND3

    Additional mRNA sequence: 

    AB209825.1 AK022376.1 AK055519.1 AK057206.1 AK096276.1 AK097856.1 AK299187.1 AK303452.1 
    AK315421.1 AL833425.1 BC011616.2 BC113829.1 CR542246.1 M90814.1 M92287.1 

    24/36 DOTS entries (see all 36):

    DT.95272637  DT.92449495  DT.451799  DT.100655604  DT.92449485  DT.92449488  DT.121342198  DT.121342234 
    DT.100645664  DT.95272627  DT.100871371  DT.100039492  DT.100839600  DT.121342343  DT.100803363  DT.70102100 
    DT.121342215  DT.121342253  DT.100655598  DT.91904779  DT.92449493  DT.100865398  DT.100655611  DT.100803504 

    24/563 AceView cDNA sequences (see all 563):

    BQ708218 BM720467 BF902757 CF131879 BG105953 BQ668607 CR613159 NM_001760 
    BX400847 AI276632 BU164011 BM753024 BQ646356 AU100320 AK057206 BG478369 
    CB153457 BX402238 BP373485 BQ690107 BP337956 CN483007 BX400719 BQ669648 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CCND3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
    SP1:              -           -     -                       -                           
    SP2:                          -     -                       -                           
    SP3:              -     -     -     -                       -                           
    SP4:                          -     -                                                   
    SP5:                          -     -           -     -     -                           


    ECgene alternative splicing isoforms for CCND3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCND3 expression in normal human tissues (normalized intensities)      CCND3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCCTCTC
    CCND3 Expression
    About this image


    CCND3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Spleen (Hematopoietic System)
             spleen ; cells in red pulp   
     
     Colon (Gastrointestinal Tract)
             colon ; peripheral nerve/ganglion   
     
     Peripheral Nervous System (Nervous System)
             colon ; peripheral nerve/ganglion   

    See CCND3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCND3

    SOURCE GeneReport for Unigene cluster: Hs.534307
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCND3: 
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCND3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCND3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCND3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCND3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCND3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCND3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnd31 , 5 cyclin D31, 5 90.41(n)1
    94.52(a)1
      17 (23.37 cM)5
    124451  NM_001081635.11  NP_001075104.11 
     475050515 
    chicken
    (Gallus gallus)
    Aves CCND31 cyclin D3 73.91(n)
    73.45(a)
      419928  NM_001008453.1  NP_001008453.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCND36
    Uncharacterized protein
    72(a)
    1 ↔ 1
    4(119230864-119256570)
    zebrafish
    (Danio rerio)
    Actinopterygii ccnd36
    im:71620846
    im:7162084
    39(a)
    32(a)
    possible ortholog
    possible ortholog
    22(512886-522929)
    3(30305087-30309514)
    fruit fly
    (Drosophila melanogaster)
    Insecta CycD3 cell proliferation cyclin-dependent
    protein kinase, more
    39(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea cyd-16
    Protein CYD-1
    18(a)
    1 → many
    II(12980591-12993118)


    ENSEMBL Gene Tree for CCND3 (if available)
    TreeFam Gene Tree for CCND3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCND3 gene
    CCNE12  CCNO2  CCNB22  CCNB32  CCNE22  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  
    4 SIMAP similar genes for CCND3 using alignment to 8 protein entries:     CCND3_HUMAN (see all proteins):
    CCND2    CCND1    cyclin D1    CCNB2V

    CCND3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CCND3
    PGOHUM00000238391 PGOHUM00000235102


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2486 SNPs in CCND3 are shown (see all 2486)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs576810331,2
    C--41696890(+) GAATG-/AATG  
            
    GATTT
    2 -- int11Minor allele frequency- AATG:0.00NA 2
    rs106034831,2
    C--41896993(+) aaaaa-/A/AA  
            
    gaaga
    2 -- int1 trp31NA 2
    rs32181141,2
    C,F,H--41902352(-) TGGTTG/AAGAAA 4 -- ds500113Minor allele frequency- A:0.16NS NA WA EA 1200
    rs2017864541,2
    --41902385(+) TATCC-/TTTTTT 4 -- ds50010--------
    rs32181131,2
    C,F,H--41902394(-) CATTTT/AAAAAA 4 -- ds50015Minor allele frequency- A:0.32NS EA 550
    rs1859978001,2
    --41902460(+) TCTTTA/TTTGTG 4 -- ds50010--------
    rs32181111,2
    C,F--41902467(-) AAAATA/G/TGCACA 4 -- ds50011NS 174
    rs32181101,2
    C,F--41902509(-) TTTATAAT/-GTGAC 4 -- ds50011Minor allele frequency- -:0.21NS 178
    rs105600801,2
    C--41902511(+) CACAT-/TATAAAgc 8 -- ds5001 cds12Minor allele frequency- TAT:0.25NA 4
    rs1449608511,2
    C--41902526(+) AACTGA/GCTATA 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCND3 (41902671 - 42018095 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for CCND3 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2301238CNV Deletion18987734
    esv1427717CNV Deletion17803354
    esv2676088CNV Deletion23128226
    esv2544548CNV Deletion19546169
    esv2659555CNV Deletion23128226
    esv2731981CNV Deletion23290073
    esv2731982CNV Deletion23290073
    nsv885834CNV Loss21882294
    nsv526116CNV Loss19592680
    nsv527131CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing CCND3:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing CCND3
    DNA2.0 Custom Variant and Variant Library Synthesis for CCND3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123834    OMIM disorders: --

    20/75 diseases for CCND3 (see all 75):    About MalaCards
    bladder carcinoma in situ    plasma cell leukemia    gliosarcoma    gastric lymphoma
    myeloma    follicular thyroid carcinoma    laryngeal squamous cell carcinoma    malignant peripheral nerve sheath tumor
    diffuse large b-cell lymphoma    differentiating neuroblastoma    malignant glioma    herpes simplex
    bladder carcinoma    mantle cell lymphoma    giant cell tumor    gastrointestinal stromal tumor
    burkitt's lymphoma    aplastic anemia    b-cell lymphomas    testicular cancer

    2 diseases from the University of Copenhagen DISEASES database for CCND3:
    Retinoblastoma     Lymphoma

    CCND3 for disorders           About GeneDecksing

    10/62 Novoseek inferred disease relationships for CCND3 gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 77.4 25 12421932 (1), 9154817 (1), 14559823 (1), 16267832 (1) (see all 25)
    plasma cell myeloma 54.9 1 15305377 (1)
    lymphoma b-cell 54.2 16 11895902 (3), 12647795 (2), 20107311 (2), 10397744 (1) (see all 11)
    tumors 49.1 73 15362377 (4), 17885491 (2), 8816437 (2), 15671552 (2) (see all 44)
    burkitt lymphoma 47.1 1 10512172 (1)
    lymphoma 43.6 27 11242797 (3), 19639271 (3), 17300668 (2), 9376597 (2) (see all 11)
    cancer 43 10 14666699 (2), 15475449 (2), 11922774 (1), 20372804 (1) (see all 8)
    monoclonal gammopathy 41 1 19996118 (1)
    leukemia lymphocytic chronic 35.9 3 11896535 (1), 19704260 (1), 9376597 (1)
    plasma cell leukemia 32.8 1 15543617 (1)

    Genetic Association Database (GAD): CCND3
    Human Genome Epidemiology (HuGE) Navigator: CCND3 (19 documents)
    Tumor Gene Database (TGDB): CCND3

    Export disorders for CCND3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCND3 gene, integrated from 9 sources (see all 498):
    (articles sorted by number of sources associating them with CCND3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. (PubMed id 1386335)1, 2, 3, 9 Inaba T....Look A.T. (1992)
    2. Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3. (PubMed id 15327989)1, 2, 9 Shen X.... Gu J. (2004)
    3. The structure of CDK4/cyclin D3 has implications for models of CDK activation. (PubMed id 19237555)1, 2, 9 Takaki T....Noble M.E. (2009)
    4. Polymorphic loci of E2F2, CCND1 and CCND3 are associated with HER2 status of breast tumors. (PubMed id 19142864)1, 4, 9 Justenhoven C....Brauch H. (2009)
    5. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. (PubMed id 15358120)1, 2, 9 Liu W.... Gu J. (2004)
    6. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. (PubMed id 1383201)1, 2, 9 Motokura T.... Arnold A. (1992)
    7. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. (PubMed id 1386336)1, 2, 9 Xiong Y.... Ward D.C. (1992)
    8. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PubMed id 19258477)1, 4, 9 Goode E.L....Sellers T.A. (2009)
    9. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4, 9 Cunningham J.M....Fridley B.L. (2009)
    10. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PubMed id 18174243)1, 4, 9 Driver K.E....Dunning A.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 896 HGNC: 1585 AceView: CCND3 Ensembl:ENSG00000112576 euGenes: HUgn896
    ECgene: CCND3 Kegg: 896 H-InvDB: CCND3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCND3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCND3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnd3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCND3 gene:
    Search GeneIP for patents involving CCND3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CCND3 (Cyclin D3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCND3  
     OriGene qPCR primer pairs and template standards for CCND3   OriGene Protein Over-expression Lysate for CCND3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CCND3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCND3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CCND3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCND3   OriGene Custom Protein Services for CCND3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCND3
     QIAGEN SeqTarget long-range PCR primers for resequencing CCND3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCND3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCND3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCND3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCND3
     GenScript Custom Purified and Recombinant Proteins Services for CCND3 GenScript cDNA clones with any tag delivered in your preferred vector for CCND3
     GenScript Custom Assay Services for CCND3 GenScript Custom Superior Antibodies Services for CCND3
     GenScript Custom overexpressing Cell Line Services for CCND3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CCND3 

     Regulatory tfbs in CCND3 promoter
     Search Chromatin IP Primers for CCND3
     RT2 qPCR Primer Assay in human, mouse, rat CCND3
     GNC Network for CCND3
     SABiosciences PCR Arrays including human, mouse, rat CCND3
     Search Tocris compounds for CCND3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CCND3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCND3 antibodies
     CCND3 proteins
     CCND3 lysates
     Antibodies for CCND3
     See all of Abcam's Antibodies, Kits and Proteins for CCND3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CCND3
     Antibodies for CCND3
     ELISAs for CCND3
     CLIAs for CCND3
     Search LifeMap BioReagents cell lines for CCND3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND3
     SwitchGear 3'UTR luciferase reporter plasmids for CCND3
     SwitchGear Promoter luciferase reporter plasmids for CCND3
     ThermoFisher Antibody for CCND3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCND3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCND3
    Customized:
     lentivirus for stable overexpression of CCND3
     lentivirus expression plasmids for stable overexpression of CCND3
     adenovirus for overexpression of CCND3
     LSBio Antibodies in human, mouse, rat for CCND3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCND3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4