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CCND3 Gene

protein-coding   GIFtS: 71
GCID: GC06M041949

Cyclin D3

  See CCND3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin D31 2
D3-Type Cyclin2
G1/S-Specific Cyclin D32
G1/S-Specific Cyclin-D32

External Ids:    HGNC: 15851   Entrez Gene: 8962   Ensembl: ENSG000001125767   OMIM: 1238345   UniProtKB: P302813   

Export aliases for CCND3 gene to outside databases

Previous GC identifers: GC06M041904 GC06M042010 GC06M041621


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCND3 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact
with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with
this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV
radiation. Several transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Oct 2008)

GeneCards Summary for CCND3 Gene:
CCND3 (cyclin D3) is a protein-coding gene. Diseases associated with CCND3 include bladder carcinoma in situ, and myeloma. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCND3_HUMAN, P30281
Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the
retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for
nuclear translocation and activity of the cyclin D-CDK4 complex

Gene Wiki entry for CCND3 (Cyclin D3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCND3 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCND3 promoter sequence
   Search Chromatin IP Primers for CCND3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCND3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21

CCND3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCND3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M041949:  view genomic region     (about GC identifiers)

Start:
41,902,671 bp from pter      End:
42,018,095 bp from pter
Size:
115,425 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCND3_HUMAN, P30281 (See protein sequence)
Recommended Name: G1/S-specific cyclin-D3  
Size: 292 amino acids; 32520 Da
Subunit: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex.
The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K.
Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of
CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A
1 PDB 3D structure from and Proteopedia for CCND3:
3G33 (3D)    
Secondary accessions: B2RD63 B3KQ22 E9PAS4 E9PB36 Q5T8J0 Q6FG62 Q96F49
Alternative splicing: 4 isoforms:  P30281-1   P30281-2   P30281-3   P30281-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCND3: NX_P30281

Explore proteomics data for CCND3 at MOPED

Post-translational modifications: 

  • Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCND3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001129489.1  NP_001129597.1  NP_001129598.1  NP_001274356.1  NP_001274363.1  NP_001751.1  

    ENSEMBL proteins: 
     ENSP00000362082   ENSP00000426212   ENSP00000362078   ENSP00000401595   ENSP00000362079  
     ENSP00000397545   ENSP00000425986   ENSP00000421511   ENSP00000423242   ENSP00000425830  
     ENSP00000425334   ENSP00000420991  
    Reactome Protein details: P30281

    CCND3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCND3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCND3
    GenScript Custom Purified and Recombinant Proteins Services for CCND3
    Novus Biologicals CCND3 Proteins
    Novus Biologicals CCND3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCND3

     
    Search eBioscience for Proteins for CCND3 

    CCND3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCND3 (Cyclin D3)
    Cell Signaling Technology (CST) Antibodies for CCND3 
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    OriGene Custom Antibody Services for CCND3
    Novus Biologicals CCND3 Antibodies
    Abcam antibodies for CCND3
    Cloud-Clone Corp. Antibodies for CCND3
    ThermoFisher Antibody for CCND3
    LSBio Antibodies in human, mouse, rat for CCND3

    CCND3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCND3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCND3
    Cloud-Clone Corp. CLIAs for CCND3
    Search eBioscience for ELISAs for CCND3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR015451 Cyclin_D
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P30281

    ProtoNet protein and cluster: P30281

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCND3_HUMAN, P30281
    Similarity: Belongs to the cyclin family. Cyclin D subfamily
    Similarity: Contains 1 cyclin N-terminal domain


    Find genes that share domains with CCND3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCND3_HUMAN, P30281
    Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the
    retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
    Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
    subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
    Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
    and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
    repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for
    nuclear translocation and activity of the cyclin D-CDK4 complex

         Genatlas biochemistry entry for CCND3:
    cyclin D3,regulator of progression through G1 phase during the cell cycle 3,33/34kDa,overexpressed with CDKN1B in
    agressive B cell lymphomas and in glioblastoma and gliosarcoma,involved in the loss of cell cycle control in a
    small fraction of malignant gliomas

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0005515protein binding IPI11896535
    GO:0019901protein kinase binding IPI8114739
         
    Find genes that share ontologies with CCND3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCND3:
     Increased cell number in G1, s 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccnd3):
     behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  normal  respiratory system 
     tumorigenesis  vision/eye 

    Find genes that share phenotypes with CCND3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccnd3tm1Pisc for CCND3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCND3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCND3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCND3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCND3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCND3:
    hsa-let-7b-5p (MIRT052181), hsa-mir-324-5p (MIRT043067), hsa-mir-34a-5p (MIRT001010), hsa-mir-424-5p (MIRT000937), hsa-mir-138-5p (MIRT006299), hsa-mir-615-3p (MIRT039712), hsa-mir-27b-3p (MIRT046238), hsa-mir-16-5p (MIRT000940), hsa-mir-195-5p (MIRT006246)

    Block miRNA regulation of human, mouse, rat CCND3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCND3 (see all 32):
    hsa-miR-642a hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-424 hsa-miR-409-5p hsa-miR-124 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCND3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCND3
    Predesigned siRNA for gene silencing in human, mouse, rat CCND3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCND3

    Clone
    Products:
         
    OriGene clones in human, mouse for CCND3 (see all 21)
    OriGene ORF clones in mouse, rat for CCND3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCND3 (NM_001136017)
    Sino Biological Human cDNA Clone for CCND3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCND3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND3
    Addgene plasmids for CCND3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCND3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCND3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCND3_HUMAN, P30281: Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear
    membrane and are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA8114739
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with CCND3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCND3 About   (see all 37)  
    See pathways by source

    SuperPathContained pathways About
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    3Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41


    Find genes that share SuperPaths with CCND3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCND3 (see all 9)
        G1-S Phase Transition
    Breast Cancer Regulation by Stathmin1
    Cyclins and Cell Cycle Regulation
    IL-10 Pathway
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for CCND3
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CCND3 (see all 9)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Signal transduction AKT signaling
    Development IGF-1 receptor signaling
    Cell cycle Cell cycle (generic schema)

    Selected BioSystems Pathways for CCND3 (see all 15)
        Focal Adhesion
    Cell cycle
    DNA damage response
    Wnt Signaling Pathway
    G1 to S cell cycle control


    2 Reactome Pathways for CCND3
        Transcriptional regulation of white adipocyte differentiation
    Cyclin D associated events in G1


    Selected Kegg Pathways  (Kegg details for CCND3) (see all 10):
        Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Wnt signaling pathway
    Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCND3: 
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCND3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCND3 (P302811, 2, 3 ENSP000003620824) via UniProtKB, MINT, STRING, and/or I2D (see all 182)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-375013,EBI-375077 MINT-50441 I2D: score=7 STRING: ENSP00000244741
    EIF3KQ9UBQ52, 3, ENSP000002483424MINT-50583 MINT-50582 MINT-50584 I2D: score=3 STRING: ENSP00000248342
    MCM10Q7L5902, 3MINT-50440 I2D: score=5 
    CDK4P118021, 2, 3, ENSP000002579044EBI-375013,EBI-295644 MINT-50438 I2D: score=10 STRING: ENSP00000257904
    CDK6Q005341, 2, 3, ENSP000002657344EBI-375013,EBI-295663 MINT-50439 I2D: score=8 STRING: ENSP00000265734
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ----
    GO:0001934positive regulation of protein phosphorylation IDA8114739
    GO:0007165signal transduction IEA--
    GO:0042098T cell proliferation IEA--
    GO:0045737positive regulation of cyclin-dependent protein kinase activity IDA8114739

    Find genes that share ontologies with CCND3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCND3

    Selected Novoseek inferred chemical compound relationships for CCND3 gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 41 22 15131122 (5), 16985050 (4), 12393642 (1), 10849422 (1) (see all 7)
    retinoic acid 38.4 27 16920920 (4), 16024653 (4), 12482873 (4), 17209053 (2) (see all 9)
    betulinic acid 31 6 19102935 (3), 19107355 (3)
    sulforaphane 29 3 12530531 (2), 15033759 (1)
    butyrate 24.8 5 10716680 (2), 11029587 (1), 14526425 (1)
    rottlerin 24.4 2 17407153 (1), 16959960 (1)
    curcumin 21 3 12674762 (2), 12483537 (1)
    phosphatidylinositol 19.1 2 16815849 (2)
    silymarin 16.1 1 16322307 (1)
    ly294002 15.8 1 16267832 (1)



    Find genes that share compounds with CCND3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCND3 gene (6 alternative transcripts): 
    NM_001136017.3  NM_001136125.2  NM_001136126.2  NM_001287427.1  NM_001287434.1  NM_001760.4  

    Unigene Cluster for CCND3:

    Cyclin D3
    Hs.534307  [show with all ESTs]
    Unigene Representative Sequence: AL833425
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000372991(uc003orn.3 uc003oro.3) ENST00000511642 ENST00000372987(uc003orm.3)
    ENST00000415497(uc011duk.2) ENST00000372988(uc003orp.3) ENST00000414200
    ENST00000510503 ENST00000511686 ENST00000512426 ENST00000513956 ENST00000506555
    ENST00000508143 ENST00000505064 ENST00000510058(uc011dul.1) ENST00000505672(uc011dum.1)
    ENST00000511161 ENST00000505884 ENST00000514382
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCND3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCND3 (see all 32):
    hsa-miR-642a hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-424 hsa-miR-409-5p hsa-miR-124 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCND3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCND3
    Predesigned siRNA for gene silencing in human, mouse, rat CCND3
    Clone
    Products:
         
    OriGene clones in human, mouse for CCND3 (see all 21)
    OriGene ORF clones in mouse, rat for CCND3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCND3 (NM_001136017)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCND3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND3
    Addgene plasmids for CCND3 
    Primer
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    OriGene qPCR primer pairs and template standards for CCND3
    OriGene qSTAR qPCR primer pairs in human, mouse for CCND3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCND3
      QuantiTect SYBR Green Assays in human, mouse, rat CCND3
      QuantiFast Probe-based Assays in human, mouse, rat CCND3

    Additional mRNA sequence: 

    AB209825.1 AK022376.1 AK055519.1 AK057206.1 AK096276.1 AK097856.1 AK299187.1 AK303452.1 
    AK315421.1 AL833425.1 BC011616.2 BC113829.1 CR542246.1 M90814.1 M92287.1 

    Selected DOTS entries (see all 36):

    DT.95272637  DT.92449495  DT.451799  DT.100655604  DT.92449485  DT.92449488  DT.121342198  DT.121342234 
    DT.100645664  DT.95272627  DT.100871371  DT.100039492  DT.100839600  DT.121342343  DT.100803363  DT.70102100 
    DT.121342215  DT.121342253  DT.100655598  DT.91904779  DT.92449493  DT.100865398  DT.100655611  DT.100803504 

    Selected AceView cDNA sequences (see all 563):

    AL135406 CF131879 BI757163 BM919489 BQ668607 BQ708218 CR598524 BG391620 
    BQ669355 BM720467 BQ225689 BU145356 BI030512 BP381788 BP338278 CR605119 
    CR600566 CR620389 BQ230039 BM475805 CR613159 NM_001760 BX400847 AI276632 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCND3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
    SP1:              -           -     -                       -                           
    SP2:                          -     -                       -                           
    SP3:              -     -     -     -                       -                           
    SP4:                          -     -                                                   
    SP5:                          -     -           -     -     -                           


    ECgene alternative splicing isoforms for CCND3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCND3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCCTCTC
    CCND3 Expression
    About this image


    CCND3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Eye (Sensory Organs)
             Mature Muller Glia Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CCND3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCND3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534307
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCND3: 
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCND3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnd31 , 5 cyclin D31, 5 90.41(n)1
    94.52(a)1
      17 (23.37 cM)5
    124451  NM_001081636.11  NP_001075105.11 
     475050515 
    chicken
    (Gallus gallus)
    Aves CCND31 cyclin D3 73.68(n)
    73.45(a)
      419928  NM_001008453.1  NP_001008453.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCND36
    cyclin D3
    71(a)
    1 ↔ 1
    4(119230864-119256570)
    zebrafish
    (Danio rerio)
    Actinopterygii ccnd2b6
    cyclin D2, b
    50(a)
    many ↔ many
    4(5006161-5026744) ENSDARG00000070408
    fruit fly
    (Drosophila melanogaster)
    Insecta CycD3 cell proliferation cyclin-dependent
    protein kinase, more
    39(a)     --


    ENSEMBL Gene Tree for CCND3 (if available)
    TreeFam Gene Tree for CCND3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCND3 gene
    CCNE12  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  
    4 SIMAP similar genes for CCND3 using alignment to 8 protein entries:     CCND3_HUMAN (see all proteins):
    CCND2    CCND1    cyclin D1    CCNB2V

    Find genes that share paralogs with CCND3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CCND3
    PGOHUM00000238391 PGOHUM00000235102


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCND3 (see all 2486)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs576810331,2
    C--41696890(+) GAATG-/AATG  
            
    GATTT
    2 -- int11Minor allele frequency- AATG:0.00NA 2
    rs106034831,2
    C--41896993(+) aaaaa-/A/AA  
            
    gaaga
    2 -- int1 trp31NA 2
    rs32181141,2
    C,F,H--41902352(-) TGGTTG/AAGAAA 4 -- ds500113Minor allele frequency- A:0.16NS NA WA EA 1200
    rs2017864541,2
    --41902385(+) TATCC-/TTTTTT 4 -- ds50010--------
    rs32181131,2
    C,F,H--41902394(-) CATTTT/AAAAAA 4 -- ds50015Minor allele frequency- A:0.32NS EA 550
    rs1859978001,2
    --41902460(+) TCTTTA/TTTGTG 4 -- ds50010--------
    rs32181111,2
    C,F--41902467(-) AAAATA/G/TGCACA 4 -- ds50011NS 174
    rs32181101,2
    C,F--41902509(-) TTTATAAT/-GTGAC 4 -- ds50011Minor allele frequency- -:0.21NS 178
    rs105600801,2
    C--41902511(+) CACAT-/TATAAAgc 8 -- ds5001 cds12Minor allele frequency- TAT:0.25NA 4
    rs1449608511,2
    C--41902526(+) AACTGA/GCTATA 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCND3 (41902671 - 42018095 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CCND3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2301238CNV Deletion18987734
    esv1427717CNV Deletion17803354
    esv2676088CNV Deletion23128226
    esv2544548CNV Deletion19546169
    esv2659555CNV Deletion23128226
    esv2731981CNV Deletion23290073
    esv2731982CNV Deletion23290073
    nsv885834CNV Loss21882294
    nsv526116CNV Loss19592680
    nsv527131CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing CCND3:
    Glioma
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing CCND3
    DNA2.0 Custom Variant and Variant Library Synthesis for CCND3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123834    OMIM disorders: --

    2 diseases for CCND3:    
    About MalaCards
    bladder carcinoma in situ    myeloma

    2 diseases from the University of Copenhagen DISEASES database for CCND3:
    Retinoblastoma     Lymphoma

    Find genes that share disorders with CCND3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCND3 gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 77.4 25 12421932 (1), 9154817 (1), 14559823 (1), 16267832 (1) (see all 25)
    plasma cell myeloma 54.9 1 15305377 (1)
    lymphoma b-cell 54.2 16 11895902 (3), 12647795 (2), 20107311 (2), 10397744 (1) (see all 11)
    tumors 49.1 73 15362377 (4), 17885491 (2), 8816437 (2), 15671552 (2) (see all 44)
    burkitt lymphoma 47.1 1 10512172 (1)
    lymphoma 43.6 27 11242797 (3), 19639271 (3), 17300668 (2), 9376597 (2) (see all 11)
    cancer 43 10 14666699 (2), 15475449 (2), 11922774 (1), 20372804 (1) (see all 8)
    monoclonal gammopathy 41 1 19996118 (1)
    leukemia lymphocytic chronic 35.9 3 11896535 (1), 19704260 (1), 9376597 (1)
    plasma cell leukemia 32.8 1 15543617 (1)

    Genetic Association Database (GAD): CCND3
    Human Genome Epidemiology (HuGE) Navigator: CCND3 (19 documents)
    Tumor Gene Database (TGDB): CCND3

    Export disorders for CCND3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCND3 gene, integrated from 10 sources (see all 503):
    (articles sorted by number of sources associating them with CCND3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. (PubMed id 1386335)1, 2, 3, 9 Inaba T....Look A.T. (Genomics 1992)
    2. Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3. (PubMed id 15327989)1, 2, 9 Shen X.... Gu J. (FEBS Lett. 2004)
    3. The structure of CDK4/cyclin D3 has implications for models of CDK activation. (PubMed id 19237555)1, 2, 9 Takaki T....Noble M.E. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. Polymorphic loci of E2F2, CCND1 and CCND3 are associated with HER2 status of breast tumors. (PubMed id 19142864)1, 4, 9 Justenhoven C....Brauch H. (Int. J. Cancer 2009)
    5. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. (PubMed id 15358120)1, 2, 9 Liu W.... Gu J. (Biochem. Biophys. Res. Commun. 2004)
    6. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. (PubMed id 1383201)1, 2, 9 Motokura T.... Arnold A. (J. Biol. Chem. 1992)
    7. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. (PubMed id 1386336)1, 2, 9 Xiong Y.... Ward D.C. (Genomics 1992)
    8. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PubMed id 19258477)1, 4, 9 Goode E.L....Sellers T.A. (amp 2009)
    9. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4, 9 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    10. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PubMed id 18174243)1, 4, 9 Driver K.E....Dunning A.M. (Carcinogenesis 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 896 HGNC: 1585 AceView: CCND3 Ensembl:ENSG00000112576 euGenes: HUgn896
    ECgene: CCND3 Kegg: 896 H-InvDB: CCND3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCND3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCND3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnd3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCND3 gene:
    Search GeneIP for patents involving CCND3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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