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Aliases for CCND3 Gene

Aliases for CCND3 Gene

  • Cyclin D3 2 3 5

External Ids for CCND3 Gene

Previous GeneCards Identifiers for CCND3 Gene

  • GC06M041904
  • GC06M041949
  • GC06M042010
  • GC06M041621

Summaries for CCND3 Gene

Entrez Gene Summary for CCND3 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

CIViC summary for CCND3 Gene

  • Cyclin D has been shown in many cancer types to be misregulated. Well established for their oncogenic properties, the cyclins and the cyclin-dependent kinases (CDK's) they activate have been the focus of major research and development efforts over the past decade. The methods by which the cyclins are misregulated are widely variable, ranging from genomic amplification to changes in promoter methylation. Cyclin D3 loss has been reported in T-ALL, a seemingly unique trend when compared to the amplifcations and overexpressions of the other cyclin D's. In a mouse study, the targeted therapeutic palbociclib significantly increased the median survival of the cyclin D3 knockouts.

GeneCards Summary for CCND3 Gene

CCND3 (Cyclin D3) is a Protein Coding gene. Diseases associated with CCND3 include Bladder Carcinoma In Situ and B-Cell Lymphomas. Among its related pathways are Development IGF-1 receptor signaling and MAPK Signaling: Mitogen Stimulation Pathway. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCND3 Gene

  • Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Gene Wiki entry for CCND3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCND3 Gene

Genomics for CCND3 Gene

Regulatory Elements for CCND3 Gene


Enhancers around CCND3 on UCSC Golden Path with GeneCards custom track

Promoters for CCND3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320635 -443 1201 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1
ENSR00000196920 1757 1601 HDGF FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZBTB7B ZNF766 ZNF207

Transcription factor binding sites by QIAGEN in the CCND3 gene promoter:

Genomic Location for CCND3 Gene

Chromosome:
6
Start:
41,934,933 bp from pter
End:
42,050,357 bp from pter
Size:
115,425 bases
Orientation:
Minus strand

Genomic View for CCND3 Gene

Genes around CCND3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCND3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCND3 Gene

Proteins for CCND3 Gene

  • Protein details for CCND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30281-CCND3_HUMAN
    Recommended name:
    G1/S-specific cyclin-D3
    Protein Accession:
    P30281
    Secondary Accessions:
    • B2RD63
    • B3KQ22
    • E9PAS4
    • E9PB36
    • Q5T8J0
    • Q6FG62
    • Q96F49

    Protein attributes for CCND3 Gene

    Size:
    292 amino acids
    Molecular mass:
    32520 Da
    Quaternary structure:
    • Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.

    Three dimensional structures from OCA and Proteopedia for CCND3 Gene

    Alternative splice isoforms for CCND3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCND3 Gene

Post-translational modifications for CCND3 Gene

  • Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCND3 (CCND3)
  • Cloud-Clone Corp. Antibodies for CCND3

No data available for DME Specific Peptides for CCND3 Gene

Domains & Families for CCND3 Gene

Gene Families for CCND3 Gene

Protein Domains for CCND3 Gene

Graphical View of Domain Structure for InterPro Entry

P30281

UniProtKB/Swiss-Prot:

CCND3_HUMAN :
  • Belongs to the cyclin family. Cyclin D subfamily.
Family:
  • Belongs to the cyclin family. Cyclin D subfamily.
genes like me logo Genes that share domains with CCND3: view

Function for CCND3 Gene

Molecular function for CCND3 Gene

GENATLAS Biochemistry:
cyclin D3,regulator of progression through G1 phase during the cell cycle 3,33/34kDa,overexpressed with CDKN1B in agressive B cell lymphomas and in glioblastoma and gliosarcoma,involved in the loss of cell cycle control in a small fraction of malignant gliomas
UniProtKB/Swiss-Prot Function:
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Gene Ontology (GO) - Molecular Function for CCND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 9106657
GO:0019901 protein kinase binding IPI 8114739
genes like me logo Genes that share ontologies with CCND3: view
genes like me logo Genes that share phenotypes with CCND3: view

Animal Models for CCND3 Gene

MGI Knock Outs for CCND3:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCND3 Gene

Localization for CCND3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCND3 Gene

Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCND3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 8114739
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CCND3: view

Pathways & Interactions for CCND3 Gene

genes like me logo Genes that share pathways with CCND3: view

SIGNOR curated interactions for CCND3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 8114739
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA --
GO:0042098 T cell proliferation IEA --
genes like me logo Genes that share ontologies with CCND3: view

Drugs & Compounds for CCND3 Gene

(30) Drugs for CCND3 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BAY1000394 Pharma Inhibition, Biomarker CDK4 Inhibitors, CDK2 Inhibitors 0
LEE011 Pharma inhibitor, Biomarker CDK4/6 inhibitor, CDK4 Inhibitors, Kinase Inhibitors 0
LY2835219 Pharma Inhibition, inhibitor, Biomarker CDK4/6 inhibitor,potent and selective, CDK4/6 inhibitor, CDK4 Inhibitors 0
PD-0332991 Pharma Biomarker CDK4 Inhibitors 0

(12) Additional Compounds for CCND3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCND3: view

Transcripts for CCND3 Gene

Unigene Clusters for CCND3 Gene

Cyclin D3:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCND3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: -

Relevant External Links for CCND3 Gene

GeneLoc Exon Structure for
CCND3
ECgene alternative splicing isoforms for
CCND3

Expression for CCND3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCND3 Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for CCND3 Gene

This gene is overexpressed in Pancreatic juice (53.7) and Peripheral blood mononuclear cells (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCND3 Gene



Protein tissue co-expression partners for CCND3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCND3 Gene:

CCND3

SOURCE GeneReport for Unigene cluster for CCND3 Gene:

Hs.534307

Evidence on tissue expression from TISSUES for CCND3 Gene

  • Blood(4.8)
  • Lung(4.7)
  • Nervous system(4.5)
  • Bone marrow(2.8)
  • Intestine(2.7)
  • Lymph node(2.7)
  • Pancreas(2.7)
  • Spleen(2.4)
  • Thyroid gland(2.4)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with CCND3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCND3 Gene

Orthologs for CCND3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCND3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCND3 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia CCND3 34 35
  • 93.84 (n)
cow
(Bos Taurus)
Mammalia CCND3 34 35
  • 93.72 (n)
mouse
(Mus musculus)
Mammalia Ccnd3 34 16 35
  • 90.41 (n)
rat
(Rattus norvegicus)
Mammalia Ccnd3 34
  • 90.07 (n)
oppossum
(Monodelphis domestica)
Mammalia CCND3 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCND3 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCND3 34 35
  • 73.68 (n)
lizard
(Anolis carolinensis)
Reptilia CCND3 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccnd2b 35
  • 50 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012299 34
  • 52.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CycD 36 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
Species where no ortholog for CCND3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCND3 Gene

ENSEMBL:
Gene Tree for CCND3 (if available)
TreeFam:
Gene Tree for CCND3 (if available)

Paralogs for CCND3 Gene

Paralogs for CCND3 Gene

(4) SIMAP similar genes for CCND3 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for CCND3 Gene

genes like me logo Genes that share paralogs with CCND3: view

Variants for CCND3 Gene

Sequence variations from dbSNP and Humsavar for CCND3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000010041 -- 42,006,249(+) CAATA(G/T)ATGTA intron-variant
rs1000012201 -- 41,960,520(+) ACAAA(A/C)CTGGG intron-variant
rs1000052894 -- 42,013,706(+) TTCAG(A/C)CTATT intron-variant
rs1000125155 -- 41,967,790(+) TGCGT(A/G)ATTCT intron-variant
rs1000173579 -- 41,999,334(+) ACCTC(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCND3 Gene

Variant ID Type Subtype PubMed ID
dgv3305n106 CNV deletion 24896259
dgv3306n106 CNV deletion 24896259
esv1427717 CNV deletion 17803354
esv2301238 CNV deletion 18987734
esv2544548 CNV deletion 19546169
esv2659555 CNV deletion 23128226
esv2676088 CNV deletion 23128226
esv2731981 CNV deletion 23290073
esv2731982 CNV deletion 23290073
esv3567701 CNV deletion 23714750
esv3567702 CNV deletion 23714750
esv3567704 CNV deletion 23714750
esv3576144 CNV gain 25503493
esv3608793 CNV loss 21293372
esv3608794 CNV loss 21293372
nsv1074394 CNV deletion 25765185
nsv1114801 CNV deletion 24896259
nsv1117617 CNV deletion 24896259
nsv1124054 CNV deletion 24896259
nsv1137075 CNV deletion 24896259
nsv1142638 CNV deletion 24896259
nsv526116 CNV loss 19592680
nsv527131 CNV loss 19592680
nsv602989 CNV loss 21841781
nsv830646 CNV loss 17160897
nsv830649 CNV loss 17160897
nsv956532 CNV deletion 24416366

Variation tolerance for CCND3 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCND3 Gene

Human Gene Mutation Database (HGMD)
CCND3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCND3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCND3 Gene

Disorders for CCND3 Gene

MalaCards: The human disease database

(15) MalaCards diseases for CCND3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bladder carcinoma in situ
  • bladder ca in situ
b-cell lymphomas
  • b-cell lymphoma
retinoblastoma
  • retinoblastoma, trilateral
burkitt lymphoma
  • burkitt's lymphoma
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards
Search CCND3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCND3

Genetic Association Database (GAD)
CCND3
Human Genome Epidemiology (HuGE) Navigator
CCND3
Tumor Gene Database (TGDB):
CCND3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCND3
genes like me logo Genes that share disorders with CCND3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCND3 Gene

Publications for CCND3 Gene

  1. The structure of CDK4/cyclin D3 has implications for models of CDK activation. (PMID: 19237555) Takaki T. … Noble M.E. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 22 64
  2. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. (PMID: 15358120) Liu W. … Gu J. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
  3. Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3. (PMID: 15327989) Shen X. … Gu J. (FEBS Lett. 2004) 3 4 22 64
  4. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. (PMID: 1386335) Inaba T. … Look A.T. (Genomics 1992) 2 3 4 64
  5. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. (PMID: 1383201) Motokura T. … Arnold A. (J. Biol. Chem. 1992) 3 4 22 64

Products for CCND3 Gene

  • Addgene plasmids for CCND3

Sources for CCND3 Gene

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