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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCND2 Gene

protein-coding GIFtS: 69
GCID: GC12P004382

cyclin D2

Explore 68 diseases affiliated with
CCND2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin D2¹ ²
KIAK0002²
G1/S-Specific Cyclin D2²
G1/S-Specific Cyclin-D2²

External Ids:	HGNC: 1583¹	Entrez Gene: 894²	Ensembl: ENSG00000118971⁷	OMIM: 123833⁵	UniProtKB: P30279³

Export aliases for CCND2 gene to outside databases

Previous GC identifers: GC12P004120 GC12P004275 GC12P004253

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCND2:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a

dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination

of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose

activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in

the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the

essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was

observed in ovarian and testicular tumors. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279

Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the

retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.

Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent

transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates

RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic

signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its

transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation

and activity of the cyclin D-CDK4 complex (By similarity)

Gene Wiki entry for CCND2 (Cyclin D2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009759.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCND2 gene promoter:
HEN1 STAT1 CP2 STAT1beta PPAR-gamma2 STAT1alpha Evi-1 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CCND2 promoter sequence

Search SABiosciences Chromatin IP Primers for CCND2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCND2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.32 HGNC cytogenetic band: 12p13

CCND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCND2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P004382: view genomic region (about GC identifiers)

Start:	4,382,902 bp from pter	End:	4,414,522 bp from pter
Size:	31,621 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279 (See protein sequence)

Recommended Name: G1/S-specific cyclin-D2

Size: 289 amino acids; 33067 Da

Subunit: Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The

cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B

required for nuclear translocation and modulation of CDK4-mediated kinase activity

Subcellular location: Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and

are then translocated into the nucleus through interaction with KIP/CIP family members (By similarity)

Secondary accessions: A8K531 Q13955 Q5U035

Explore the universe of human proteins at neXtProt for CCND2: NX_P30279

Post-translational modifications:

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30279

CCND2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001750.1

ENSEMBL proteins:

ENSP00000261254 ENSP00000442807

Reactome Protein details: P30279
Human Recombinant Protein Products:

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	Novus Biologicals CCND2 Proteins Novus Biologicals CCND2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCND2
	Uscn Proteins for CCND2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IDA	8114739
GO:0000785	chromatin	IDA	18827403
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005829	cytosol	IDA	18827403

CCND2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CCND2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCND2 for domains About GeneDecksing

4 InterPro domains/families:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR004367 Cyclin_C

IPR014400 Cyclin_A/B/D/E

Graphical View of Domain Structure for InterPro Entry P30279

ProtoNet protein and cluster: P30279

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279

Similarity: Belongs to the cyclin family. Cyclin D subfamily

Similarity: Contains 1 cyclin N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279

Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the

retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.

Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent

transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates

RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic

signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its

transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation

and activity of the cyclin D-CDK4 complex (By similarity)

Genatlas biochemistry entry for CCND2:

cyclin D2,regulator of progression through G1 phase during the cell cycle 2,FSH responsive,involved in gonadal cell

proliferation and oncogenesis,overexpressed in astrocytomas and in glioblastomas

miRNA Products:		miRTarBase miRNAs that target CCND2: hsa-mir-26a (MIRT000112), hsa-mir-106b (MIRT005862), hsa-let-7a (MIRT005478), hsa-mir-302d (MIRT005673), hsa-let-7b (MIRT003835), hsa-mir-302b (MIRT003555), hsa-mir-17 (MIRT005848), hsa-mir-20a (MIRT005854), hsa-mir-15a (MIRT000285)

		OriGene 3'-UTR Clone: CCND2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCND2
		8/161 QIAGEN miScript miRNA Assays for microRNAs that regulate CCND2 (see all 161):
		hsa-miR-520f hsa-miR-3938 hsa-miR-106a hsa-miR-138-2* hsa-miR-520b hsa-miR-374b* hsa-miR-224* hsa-let-7e

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCND2 (see all 7) OriGene shRNA RFP: CCND2 OriGene siRNA: CCND2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCND2

Gene Editing
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DNA2.0 Custom Protein Engineering Service for CCND2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0019901	protein kinase binding	IPI	8114739

CCND2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for CCND2:

Increased cell death HMECs cel

Increased cell death in breast

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Ccnd2^tm1Wbg for CCND2
12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ccnd2):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	liver/biliary system	mortality/aging	nervous system
reproductive system	vision/eye

CCND2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell cycle_Cell cycle (generic schema)

	Cell cycle_Cell cycle (generic schema)	1.00			Cell cycle_Regulation of G1/S transition (part 2)	0.38
	Cell cycle Cell cycle (generic schema)	1.00			Cell cycle Regulation of G1/S transition (part 2)	0.38

Development IGF-RI signaling

	Development IGF-RI signaling	1.00			Signal transduction_AKT signaling	0.49
	Development_IGF-1 receptor signaling	0.99			Signal transduction AKT signaling	0.49

Wnt Signaling Pathway

	Wnt Signaling Pathway	1.00			DNA damage response (only ATM dependent)	0.35
	Wnt Signaling Pathway and Pluripotency	0.55			Wnt signaling pathway	0.30

Cyclins and Cell Cycle Regulation

	Cyclins and Cell Cycle Regulation	1.00			Cyclin D associated events in G1	0.32
	G1-S Phase Transition	0.67			G1 Phase	0.32

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for CCND2 (see all 7)

	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Regulation of G1/S transition (part 2)
	Cell cycle Regulation of G1/S transition (part 1)
	Signal transduction AKT signaling
	Immune response MIF-JAB1 signaling

5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCND2 (see all 10)

	IL-10 Pathway
	Molecular Mechanisms of Cancer
	Calpain Protease Regulates Cellular Mechanics
	Colorectal Cancer Metastasis
	Breast Cancer Regulation by Stathmin1

1 Cell Signaling Technology (CST) Pathway for CCND2

Cell Cycle / Checkpoint Control

5/7 GeneGo (Thomson Reuters) Pathways for CCND2 (see all 7)

	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Regulation of G1/S transition (part 2)
	Cell cycle Regulation of G1/S transition (part 1)
	Signal transduction AKT signaling
	Development IGF-1 receptor signaling

5/15 BioSystems Pathways for CCND2 (see all 15)

	DNA damage response
	Wnt Signaling Pathway and Pluripotency
	Focal Adhesion
	SRF and miRs in Smooth Muscle Differentiation and Proliferation
	Wnt Signaling Pathway

5 Reactome Pathways for CCND2

	G1 Phase
	Mitotic G1-G1/S phases
	Cell Cycle
	Cell Cycle, Mitotic
	Cyclin D associated events in G1

5/6 Kegg Pathways (Kegg details for CCND2) (see all 6):

	Cell cycle
	p53 signaling pathway
	Wnt signaling pathway
	Focal adhesion
	Jak-STAT signaling pathway

CCND2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCND2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/64 Interacting proteins for CCND2 (P30279^{2, 3} ENSP00000261254⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PCGF2	P35227²^,³, ENSP00000354033⁴	MINT-65936 MINT-65938 MINT-65937 MINT-65935 I2D: score=2 STRING: ENSP00000354033
CDKN1B	P46527²^,³, ENSP00000228872⁴	MINT-67874 I2D: score=6 STRING: ENSP00000228872
CDKN1A	P38936²^,³, ENSP00000244741⁴	MINT-2635378 I2D: score=5 STRING: ENSP00000244741
CDK4	P11802³, ENSP00000257904⁴	I2D: score=7 STRING: ENSP00000257904
AKAP8	O43823³, ENSP00000269701⁴	I2D: score=3 STRING: ENSP00000269701

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001541	ovarian follicle development	--	--
GO:0001889	liver development	--	--
GO:0001934	positive regulation of protein phosphorylation	IDA	8114739
GO:0007049	cell cycle	IEA	--
GO:0007283	spermatogenesis	--	--

CCND2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCND2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCND2
10/25 Novoseek chemical compound relationships for CCND2 gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
butyrolactone i	49.2	2	10378783 (1)
rapamycin	38.4	9	15131122 (1), 12884287 (1), 15677443 (1), 17452903 (1) (see all 7)
5-aza-2'deoxycytidine	33.2	5	12684418 (1), 15304843 (1), 12771922 (1), 14612939 (1)
bromodeoxyuridine	32.7	5	15245432 (3), 15755480 (1), 15379904 (1)
phosphatidylinositol	28	5	14660677 (2), 12884287 (1), 17486076 (1), 19464003 (1)
thymidine	23.6	1	12217398 (1)
imatinib	22.8	5	15509806 (3), 11691826 (1)
retinoic acid	19.6	7	9778049 (2), 10585260 (1), 15498118 (1), 19956520 (1) (see all 6)
tyrosine	14.8	9	10930570 (3), 14990053 (3), 17537993 (1), 11691826 (1)
herbimycin a	11.2	2	8710379 (1), 10930570 (1)

Search CenterWatch for drugs/clinical trials and news about CCND2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCND2 gene:

NM_001759.3

Unigene Cluster for CCND2:

Cyclin D2

Hs.376071 [show with all ESTs]

Unigene Representative Sequence: NM_001759

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261254(uc001qmo.3) ENST00000536537 ENST00000536795 ENST00000541542

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCND2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCND2

Additional cDNA sequence:

AK223577.1 AK291146.1 BC010958.1 BC014357.1 BC089384.1 BT019847.1 BX647508.1 D13639.1

M90813.1 X68452.1

16 DOTS entries:

DT.95139513 DT.418769 DT.100027257 DT.97825041 DT.121197504 DT.70100480 DT.75193426 DT.100643619

DT.121197494 DT.121197513 DT.95177141 DT.95263984 DT.121197523 DT.121197541 DT.95263988 DT.95264009

24/470 AceView cDNA sequences (see all 470):

AA885870 BI916864 BG697904 AW365080 AW087405 AI681249 BG319487 AA485301

BX389538 BG287657 BQ574704 BP344026 AA587183 BF089595 AW590428 AI650875

AW008625 AA598876 X68452 AA550847 AA485300 BG291402 AA311165 AW849412

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCND2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATAGTCAG

About this image

CCND2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatogonium Type A

Germ Cells, Male Gametocytes

Testis

Seminiferous Tubules

Spermatogonium Type B

Germ Cells, Male Gametocytes

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Diencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Epiblast-like cells (Reconstitution of mo...)

See CCND2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCND2

SOURCE GeneReport for Unigene cluster: Hs.376071

SABiosciences Expression via Pathway-Focused PCR Arrays including CCND2 (see all 12):

WNT Signaling Pathway in human mouse rat

Cancer PathwayFinder in human mouse rat

Prostate Cancer in human mouse rat

Liver Cancer in human mouse rat

Stem Cells in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCND2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCND2 gene from 7/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCND2¹	cyclin D2	79.24(n) 85.12(a)		374047 NM_204213.1 NP_989544.1
African clawed frog (Xenopus laevis)	Amphibia	ccnd2-A²	cyclin D2	81.69(n)		X83503.1
zebrafish (Danio rerio)	Actinopterygii	ccnd2a¹	cyclin D2, a	70.93(n) 81.66(a)		799608 NM_001089445.1 NP_001082914.1
fruit fly (Drosophila melanogaster)	Insecta	CycD^{1 , 3}	cell proliferation cyclin-dependent protein kinase, more³ Cyclin D¹	44(a)³ 53.5(n)¹ 41.56(a)¹		32551¹ NM_078631.3¹ NP_523355.2¹
worm (Caenorhabditis elegans)	Secernentea	cyd-1⁶	CYclin D family member (cyd-1)	14(a)	1 → many	II(12980522-12993049)
thale cress (Arabidopsis thaliana)	eudicotyledons	SDS⁶	cyclin-SDS	6(a)	possible ortholog	1(5079407-5082520)
rice (Oryza sativa)	Liliopsida	--	cyclin, putative, expressed	10(a)	possible ortholog	3(6555387-6561025)

ENSEMBL Gene Tree for CCND2 (if available)
TreeFam Gene Tree for CCND2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CCND2 gene

CCND3² CCNO² CCNE1² CCNB2² CCNE2² CCNB3² CCNB1² CCND1²

CCNA1² CCNA2²

2 SIMAP similar genes for CCND2 using alignment to 2 protein entries: CCND2_HUMAN (see all proteins):

CCND1 CCND3

CCND2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CCND2
PGOHUM00000242760

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186970590^1,2		--	4380919(+)	`CCGCGA/GCGCTG`	1	--	us2k¹		0	--	--	--	--
rs73247741^1,2	C,	--	4381102(+)	`CGGCCG/TGGCCT`	1	--	us2k¹		1		WA	2
rs78455191^1,2		--	4381345(+)	`CCCCTC/GCTTTC`	1	--	us2k¹		0	--	--	--	--
rs151064550^1,2		--	4381545(+)	`GGTGAC/GGGAGG`	1	--	us2k¹		0	--	--	--	--
rs114033441^1,2	F,	--	4381566(+)	`GCCTCG/CGTGTG`	1	--	us2k¹		1		WA	118
rs6489531^1,2	C,H,	--	4381763(+)	`TCAAGG/CATGCG`	1	--	us2k¹		8		NA WA CSA	14
rs190654441^1,2		--	4381946(+)	`CGCAGA/GGGGAG`	1	--	us2k¹		0	--	--	--	--
rs7304270^1,2	C,	--	4381981(+)	`TCACTC/TGCCCC`	1	--	us2k¹ tfbs³		4		WA NA EA	360
rs138756277^1,2		--	4382159(+)	`CCCTAA/GACGCT`	1	--	us2k¹		0	--	--	--	--
rs74058824^1,2	C,	--	4382256(+)	`CACCCC/TCCTTC`	1	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for CCND2 (4382902 - 4414522 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCND2
1 CNV: 1246

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing CCND2:

Oncogenes & Tumor Suppressor Genes 384HC

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCND2

DNA2.0 Custom Variant and Variant Library Synthesis for CCND2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCND2 for disorders           About GeneDecksing

OMIM gene information: 123833    OMIM disorders: --

20/68 diseases for CCND2 (see all 68):    About MalaCards

progesterone-receptor negative breast cancer diffuse large b-cell lymphoma human t-cell leukemia virus type 1 b-cell lymphomas

germ cell tumor testicular germ cell tumor male germ cell tumor non-hodgkin lymphoma

anaplastic astrocytoma burkitt's lymphoma mantle cell lymphoma malignant glioma

lymphoblastic leukemia wilms tumor peripheral t-cell lymphoma myeloid leukemia

hodgkin's lymphoma adult t-cell leukemia leukemia acute lymphoblastic leukemia

4 diseases from the University of Copenhagen DISEASES database for CCND2:

Retinoblastoma Lymphoma Multiple myeloma Leukemia

10/52 Novoseek disease relationships for CCND2 gene (see all 52) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	72.6	17	7784057 (1), 19145199 (1), 17897300 (1), 9103470 (1) (see all 17)
leukemia t-cell	63.4	3	11314046 (1), 15169570 (1)
seminoma	55.4	4	9056671 (1), 15747581 (1), 14612934 (1)
tumors	54.3	65	10666388 (3), 14581343 (2), 18661512 (2), 10935479 (2) (see all 44)
carcinoma embryonal	53.6	5	12777997 (2), 9056671 (1), 18930031 (1)
medulloblastoma	52.5	3	12959442 (1), 19164512 (1)
lymphoma	51.9	26	20062012 (4), 11291051 (3), 19608671 (2), 18391076 (1) (see all 11)
lymphoma b-cell	48.7	5	20016842 (1), 17593082 (1), 15920548 (1), 17038524 (1) (see all 5)
myeloma	46.9	13	18431519 (3), 9565604 (2), 11552984 (1), 19196658 (1) (see all 6)
burkitt lymphoma	46.8	3	8455931 (1), 8045261 (1)

Human Genome Epidemiology (HuGE) Navigator: CCND2 (15 documents)
Tumor Gene Database (TGDB): CCND2

Export disorders for CCND2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCND2 gene, integrated from 9 sources (see all 479):
(articles sorted by number of sources associating them with CCND2)

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Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. (PubMed id 1386335)^{1, 2, 3, 9} Inaba T....Look A.T. (1992)
Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines. (PubMed id 8455931)^{1, 2, 9} Palmero I.... Peters G. (1993)
Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. (PubMed id 18827403)^{1, 2, 9} Wang Z....Meng A. (2008)
Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. (PubMed id 1386336)^{1, 2, 9} Xiong Y.... Ward D.C. (1992)
F-box protein FBXL2 targets cyclin D2 for ubiquitinati on and degradation to inhibit leukemic cell proliferation. (PubMed id 22323446)^{1, 2} Chen B.B....Mallampalli R.K. (2012)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Restoration of cyclin D2 has an inhibitory potential on the proliferation of LNCaP cells. (PubMed id 19577536)^{1, 9} Kobayashi T....Inoue T. (2009)
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. (PubMed id 15509806)^{1, 9} Fernandez de Mattos S....Lam E.W. (2004)
Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer. (PubMed id 12771922)^{1, 9} Yu J....Sung J.J. (2003)
Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia. (PubMed id 16548914)^{1, 9} Karrman K....Johansson B. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 894	HGNC: 1583	AceView: CCND2	Ensembl:ENSG00000118971	euGenes: HUgn894
ECgene: CCND2	Kegg: 894	H-InvDB: CCND2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCND2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCND2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccnd2/

Intellectual Property for CCND2 gene
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Patent Information for CCND2 gene:
Search GeneIP for patents involving CCND2

GeneCards and IP:
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cyclin D2

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