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CCND2 Gene

protein-coding   GIFtS: 70
GCID: GC12P004382

Cyclin D2

  See CCND2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin D21 2
G1/S-Specific Cyclin D21 2
KIAK00022
G1/S-Specific Cyclin-D22

External Ids:    HGNC: 15831   Entrez Gene: 8942   Ensembl: ENSG000001189717   OMIM: 1238335   UniProtKB: P302793   

Export aliases for CCND2 gene to outside databases

Previous GC identifers: GC12P004120 GC12P004275 GC12P004253


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCND2 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact
with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous
gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High
level expression of this gene was observed in ovarian and testicular tumors. (provided by RefSeq, Oct 2008)

GeneCards Summary for CCND2 Gene:
CCND2 (cyclin D2) is a protein-coding gene. Diseases associated with CCND2 include megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome, and posterior uveal melanoma. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279
Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the
retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for
nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity)

Gene Wiki entry for CCND2 (Cyclin D2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCND2 gene promoter:
         HEN1   STAT1   CP2   STAT1beta   PPAR-gamma2   STAT1alpha   Evi-1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CCND2 promoter sequence
   Search Chromatin IP Primers for CCND2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCND2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.32   HGNC cytogenetic band: 12p13

CCND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCND2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P004382:  view genomic region     (about GC identifiers)

Start:
4,382,902 bp from pter      End:
4,414,522 bp from pter
Size:
31,621 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279 (See protein sequence)
Recommended Name: G1/S-specific cyclin-D2  
Size: 289 amino acids; 33067 Da
Subunit: Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex.
The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin
D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity
Secondary accessions: A8K531 Q13955 Q5U035

Explore the universe of human proteins at neXtProt for CCND2: NX_P30279

Explore proteomics data for CCND2 at MOPED

Post-translational modifications: 

  • Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCND2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001750.1  
    ENSEMBL proteins: 
     ENSP00000261254   ENSP00000442807  
    Reactome Protein details: P30279

    CCND2 Human Recombinant Protein Products:

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    Novus Biologicals CCND2 Proteins
    Novus Biologicals CCND2 Lysates
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    ProSpec Recombinant Protein for CCND2
    Cloud-Clone Corp. Proteins for CCND2

     
    Search eBioscience for Proteins for CCND2 

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    Cloud-Clone Corp. ELISAs for CCND2
    Cloud-Clone Corp. CLIAs for CCND2
    Search eBioscience for ELISAs for CCND2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR015451 Cyclin_D
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P30279

    ProtoNet protein and cluster: P30279

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279
    Similarity: Belongs to the cyclin family. Cyclin D subfamily
    Similarity: Contains 1 cyclin N-terminal domain


    Find genes that share domains with CCND2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCND2_HUMAN, P30279
    Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the
    retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
    Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
    subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
    Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
    and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
    repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for
    nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity)

         Genatlas biochemistry entry for CCND2:
    cyclin D2,regulator of progression through G1 phase during the cell cycle 2,FSH responsive,involved in gonadal
    cell proliferation and oncogenesis,overexpressed in astrocytomas and in glioblastomas

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0019901protein kinase binding IPI8114739
         
    Find genes that share ontologies with CCND2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CCND2:
     Increased cell death HMECs cel  Increased cell death in breast  Synthetic lethal with Ras 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccnd2):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  nervous system  reproductive system 
     vision/eye 

    Find genes that share phenotypes with CCND2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccnd2tm1Wbg for CCND2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCND2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCND2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCND2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCND2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCND2:
    hsa-mir-342-3p (MIRT043702), hsa-mir-196a-5p (MIRT026074), hsa-mir-26a-5p (MIRT000112), hsa-mir-302d-3p (MIRT005673), hsa-mir-877-5p (MIRT037251), hsa-let-7b-5p (MIRT003835), hsa-mir-16-5p (MIRT003431), hsa-mir-335-5p (MIRT018710), hsa-mir-615-3p (MIRT040184), hsa-mir-324-3p (MIRT042861), hsa-mir-206 (MIRT007217), hsa-let-7a-5p (MIRT005478), hsa-mir-106b-5p (MIRT005862), hsa-mir-182-5p (MIRT007064), hsa-mir-19b-3p (MIRT031274), hsa-mir-301a-3p (MIRT044222), hsa-mir-320a (MIRT044790), hsa-mir-302b-3p (MIRT003555), hsa-mir-378a-3p (MIRT043920), hsa-mir-17-5p (MIRT005848), hsa-mir-20a-5p (MIRT005854), hsa-mir-423-5p (MIRT038097), hsa-mir-15a-5p (MIRT000285), hsa-mir-877-3p (MIRT036978)

    Block miRNA regulation of human, mouse, rat CCND2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCND2 (see all 161):
    hsa-miR-520f hsa-miR-3938 hsa-miR-106a hsa-miR-138-2* hsa-miR-520b hsa-miR-374b* hsa-miR-224* hsa-let-7e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: CCND2 (NM_001759)
    Sino Biological Human cDNA Clone for CCND2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCND2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND2
    Addgene plasmids for CCND2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCND2_HUMAN, P30279: Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear
    membrane and are then translocated into the nucleus through interaction with KIP/CIP family members (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    extracellular2
    cytoskeleton1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA18827403
    GO:0000785chromatin IDA18827403
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol IDA18827403

    Find genes that share ontologies with CCND2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCND2 About   (see all 39)  
    See pathways by source

    SuperPathContained pathways About
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    3Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    4Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    5p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41


    Find genes that share SuperPaths with CCND2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCND2 (see all 10)
        IL-10 Pathway
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics
    Colorectal Cancer Metastasis
    Breast Cancer Regulation by Stathmin1

    1 Cell Signaling Technology (CST) Pathway for CCND2
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CCND2 (see all 7)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle Regulation of G1/S transition (part 1)
    Signal transduction AKT signaling
    Development IGF-1 receptor signaling

    Selected BioSystems Pathways for CCND2 (see all 16)
        Focal Adhesion
    Cell cycle
    DNA damage response
    Wnt Signaling Pathway
    G1 to S cell cycle control


    1 Reactome Pathway for CCND2
        Cyclin D associated events in G1


    Selected Kegg Pathways  (Kegg details for CCND2) (see all 14):
        FoxO signaling pathway
    Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Wnt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCND2 (see all 12): 
              WNT Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Prostate Cancer in human mouse rat
              Liver Cancer in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCND2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCND2 (P302791, 2, 3 ENSP000002612544) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-748789,EBI-375077 MINT-2635378 I2D: score=5 STRING: ENSP00000244741
    PCGF2P352272, 3, ENSP000003540334MINT-65936 MINT-65938 MINT-65937 MINT-65935 I2D: score=2 STRING: ENSP00000354033
    CDKN1BP465272, 3, ENSP000002288724MINT-67874 I2D: score=6 STRING: ENSP00000228872
    CDK4P118023, ENSP000002579044I2D: score=7 STRING: ENSP00000257904
    AKAP8O438233, ENSP000002697014I2D: score=3 STRING: ENSP00000269701
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ----
    GO:0001934positive regulation of protein phosphorylation IDA8114739
    GO:0007049cell cycle IEA--
    GO:0045737positive regulation of cyclin-dependent protein kinase activity IDA8114739
    GO:0051301cell division IEA--

    Find genes that share ontologies with CCND2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCND2

    Selected Novoseek inferred chemical compound relationships for CCND2 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butyrolactone i 49.2 2 10378783 (1)
    rapamycin 38.4 9 15131122 (1), 12884287 (1), 15677443 (1), 17452903 (1) (see all 7)
    5-aza-2'deoxycytidine 33.2 5 12684418 (1), 15304843 (1), 12771922 (1), 14612939 (1)
    bromodeoxyuridine 32.7 5 15245432 (3), 15755480 (1), 15379904 (1)
    phosphatidylinositol 28 5 14660677 (2), 12884287 (1), 17486076 (1), 19464003 (1)
    thymidine 23.6 1 12217398 (1)
    imatinib 22.8 5 15509806 (3), 11691826 (1)
    retinoic acid 19.6 7 9778049 (2), 10585260 (1), 15498118 (1), 19956520 (1) (see all 6)
    tyrosine 14.8 9 10930570 (3), 14990053 (3), 17537993 (1), 11691826 (1)
    herbimycin a 11.2 2 8710379 (1), 10930570 (1)



    Find genes that share compounds with CCND2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCND2 gene: 
    NM_001759.3  

    Unigene Cluster for CCND2:

    Cyclin D2
    Hs.376071  [show with all ESTs]
    Unigene Representative Sequence: NM_001759
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261254(uc001qmo.3) ENST00000536537 ENST00000536795 ENST00000541542

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    Selected qRT-PCR Assays for microRNAs that regulate CCND2 (see all 161):
    hsa-miR-520f hsa-miR-3938 hsa-miR-106a hsa-miR-138-2* hsa-miR-520b hsa-miR-374b* hsa-miR-224* hsa-let-7e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND2
    Addgene plasmids for CCND2 
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    OriGene qPCR primer pairs and template standards for CCND2
    OriGene qSTAR qPCR primer pairs in human, mouse for CCND2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCND2
      QuantiTect SYBR Green Assays in human, mouse, rat CCND2
      QuantiFast Probe-based Assays in human, mouse, rat CCND2

    Additional mRNA sequence: 

    AK223577.1 AK291146.1 BC010958.1 BC014357.1 BC089384.1 BT019847.1 BX647508.1 D13639.1 
    M90813.1 X68452.1 

    16 DOTS entries:

    DT.95139513  DT.418769  DT.100027257  DT.97825041  DT.121197504  DT.70100480  DT.75193426  DT.100643619 
    DT.121197494  DT.121197513  DT.95177141  DT.95263984  DT.121197523  DT.121197541  DT.95263988  DT.95264009 

    Selected AceView cDNA sequences (see all 470):

    C05060 AW263260 AI083619 AV710808 C01834 AA136888 BG697904 CA396682 
    AW337771 AA327695 AW365080 BG319487 AA587183 AW008625 BG287657 BE763184 
    T28541 AW590428 AA977482 BQ574704 BM663326 CA393509 W80990 CR600898 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCND2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATAGTCAG
    CCND2 Expression
    About this image


    CCND2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Gonad
             Primordial Germ Cells Allantois
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             Thymus
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Basal Cells Respiratory Bronchioles
             Stem Bronchi
    CCND2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCND2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.376071
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCND2 (see all 12): 
              WNT Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Prostate Cancer in human mouse rat
              Liver Cancer in human mouse rat
              Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCND2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnd21 , 5 cyclin D21, 5 89.47(n)1
    92.36(a)1
      6 (61.92 cM)5
    124441  NM_009829.31  NP_033959.11 
     1271257795 
    chicken
    (Gallus gallus)
    Aves CCND21 cyclin D2 79.12(n)
    85.12(a)
      374047  NM_204213.1  NP_989544.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia ccnd2-A2 cyclin D2 81.69(n)    X83503.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnd2a1 cyclin D2, a 70.93(n)
    81.66(a)
      799608  NM_001089445.1  NP_001082914.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycD1 , 3 cell proliferation cyclin-dependent
    protein kinase, more3
    Cyclin D1
    44(a)3
    55.23(n)1
    45.89(a)1
      325511  NM_167473.21  NP_727913.21 


    ENSEMBL Gene Tree for CCND2 (if available)
    TreeFam Gene Tree for CCND2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCND2 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  
    CCNA12  CCNA22  
    2 SIMAP similar genes for CCND2 using alignment to 2 protein entries:     CCND2_HUMAN (see all proteins):
    CCND1    CCND3

    Find genes that share paralogs with CCND2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCND2
    PGOHUM00000242760


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCND2 (see all 753)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869705901,2
    --4380919(+) CCGCGA/GCGCTG 1 -- us2k10--------
    rs732477411,2
    C,F--4381102(+) CGGCCG/TGGCCT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs784551911,2
    --4381345(+) CCCCTC/GCTTTC 1 -- us2k10--------
    rs1510645501,2
    --4381545(+) GGTGAC/GGGAGG 1 -- us2k10--------
    rs1140334411,2
    F--4381566(+) GCCTCG/CGTGTG 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs64895311,2
    C,H--4381763(+) TCAAGG/CATGCG 1 -- us2k18Minor allele frequency- C:0.00NA WA CSA 14
    rs1906544411,2
    C--4381946(+) CGCAGA/GGGGAG 1 -- us2k10--------
    rs73042701,2
    C--4381981(+) TCACTC/TGCCCC 1 -- us2k1 tfbs34Minor allele frequency- T:0.14WA NA EA 360
    rs1387562771,2
    --4382159(+) CCCTAA/GACGCT 1 -- us2k10--------
    rs740588241,2
    C,F--4382256(+) CACCCC/TCCTTC 1 -- us2k12Minor allele frequency- T:0.02WA 120

    HapMap Linkage Disequilibrium report for CCND2 (4382902 - 4414522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CCND2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745447CNV Deletion23290073
    esv2674492CNV Deletion23128226
    dgv260n67CNV Loss20364138
    esv275292CNV Loss21479260
    nsv468984CNV Loss19166990
    nsv437722CNV Loss16327808
    nsv832317CNV Gain17160897
    esv275173CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing CCND2:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing CCND2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCND2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123833    OMIM disorders: --

    5 diseases for CCND2:    
    About MalaCards
    megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome    posterior uveal melanoma    male germ cell tumor    mantle cell lymphoma
    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for CCND2:
    Retinoblastoma     Lymphoma     Multiple myeloma     Leukemia

    Find genes that share disorders with CCND2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCND2 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 72.6 17 7784057 (1), 19145199 (1), 17897300 (1), 9103470 (1) (see all 17)
    leukemia t-cell 63.4 3 11314046 (1), 15169570 (1)
    seminoma 55.4 4 9056671 (1), 15747581 (1), 14612934 (1)
    tumors 54.3 65 10666388 (3), 14581343 (2), 18661512 (2), 10935479 (2) (see all 44)
    carcinoma embryonal 53.6 5 12777997 (2), 9056671 (1), 18930031 (1)
    medulloblastoma 52.5 3 12959442 (1), 19164512 (1)
    lymphoma 51.9 26 20062012 (4), 11291051 (3), 19608671 (2), 18391076 (1) (see all 11)
    lymphoma b-cell 48.7 5 20016842 (1), 17593082 (1), 15920548 (1), 17038524 (1) (see all 5)
    myeloma 46.9 13 18431519 (3), 9565604 (2), 11552984 (1), 19196658 (1) (see all 6)
    burkitt lymphoma 46.8 3 8455931 (1), 8045261 (1)

    Genetic Association Database (GAD): CCND2
    Human Genome Epidemiology (HuGE) Navigator: CCND2 (15 documents)
    Tumor Gene Database (TGDB): CCND2

    Export disorders for CCND2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCND2 gene, integrated from 10 sources (see all 499):
    (articles sorted by number of sources associating them with CCND2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. (PubMed id 1386335)1, 2, 3, 9 Inaba T....Look A.T. (Genomics 1992)
    2. Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines. (PubMed id 8455931)1, 2, 9 Palmero I.... Peters G. (Oncogene 1993)
    3. Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition. (PubMed id 18827403)1, 2, 9 Wang Z.... Meng A. (Cell Struct. Funct. 2008)
    4. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. (PubMed id 1386336)1, 2, 9 Xiong Y.... Ward D.C. (Genomics 1992)
    5. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PubMed id 19258477)1, 4, 9 Goode E.L....Sellers T.A. (amp 2009)
    6. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PubMed id 18174243)1, 4, 9 Driver K.E....Dunning A.M. (Carcinogenesis 2008)
    7. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PubMed id 18281541)1, 4, 9 Song H....Gayther S.A. (Clin. Cancer Res. 2008)
    8. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PubMed id 18507837)1, 4, 9 Azzato E.M....Pharoah P.D. (Breast Cancer Res. 2008)
    9. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PubMed id 17409409)1, 4, 9 Gayther S.A....Pharoah P.D. (Cancer Res. 2007)
    10. F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. (PubMed id 22323446)1, 2 Chen B.B.... Mallampalli R.K. (Blood 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 894 HGNC: 1583 AceView: CCND2 Ensembl:ENSG00000118971 euGenes: HUgn894
    ECgene: CCND2 Kegg: 894 H-InvDB: CCND2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCND2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCND2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnd2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCND2 gene:
    Search GeneIP for patents involving CCND2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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