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CCND2 Gene

protein-coding GIFtS: 71

GC12P004253

cyclin D2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
KIAK0002 ^²
MGC102758 ^²

Descriptions
G1/S-specific cyclin D2 ^²
cyclin D2 ^²

External Ids
HGNC: 1583¹
Entrez Gene: 894²
UniProtKB: P30279³
Ensembl: ENSG00000118971⁷

Search outside databases for aliases for CCND2 gene

Previous GC identifers: GC12P004120 GC12P004275

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CCND2:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are

characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins

function as regulators of CDK kinases. Different cyclins exhibit distinct expression and

degradation patterns which contribute to the temporal coordination of each mitotic event. This

cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity

is required for cell cycle G1/S transition. This protein has been shown to interact with and be

involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous

gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell

proliferation. High level expression of this gene was observed in ovarian and testicular tumors.

[provided by RefSeq]

UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279

Function: Essential for the control of the cell cycle at the G1/S (start) transition

Gene Wiki entry for CCND2 (Cyclin_D2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CCND2 gene

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.32 HGNC cytogenetic band: 12p13

CCND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P004253: (about GC identifiers)

Start:	4,253,199 bp from pter
End:	4,284,777 bp from pter
Size:	31,579 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009759.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279 (See protein sequence)

Recommended Name: G1/S-specific cyclin-D2

Size: 289 amino acids; 33067 Da

Subunit: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase

holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex

Secondary accessions: Q13955 Q5U035

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001750.1

ENSEMBL proteins:

ENSP00000261254

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cyclin D2)
	Human Recombinant Proteins from Abnova (CCND2)

OriGene Purified Recombinant Human Protein: CCND2

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IDA	8114739
GO:0005634	nucleus	IEA	--

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Antibodies for CCND2:

	Invitrogen Antibodies for CCND2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for CCND2
	R&D Systems Antibodies for CCND2 (Cyclin D2)
	Cell Signaling Technology (CST) Antibodies for CCND2 (Cyclin D2)
	Antibodies from Abcam (Cyclin D2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CCND2)
	Novus Biologicals Antibodies for CCND2

Assays for CCND2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P30279

ProtoNet protein and cluster: P30279

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279

Similarity: Belongs to the cyclin family. Cyclin D subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCND2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCND2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001759

Applied Biosystems Silencer® siRNAs for CCND2

Sigma-Aldrich siRNA and siRNA Panels for CCND2

Sigma-Aldrich shRNA Panels and shRNA for CCND2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CCND2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001759
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001759
untagged cDNA clone in CMV expression vector: NM_001759

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001759

UniProtKB/Swiss-Prot: CCND2_HUMAN, P30279

Function: Essential for the control of the cell cycle at the G1/S (start) transition

Genatlas biochemistry entry for CCND2:

cyclin D2,regulator of progression through G1 phase during the cell cycle 2,FSH responsive,involved

in gonadal cell proliferation and oncogenesis,overexpressed in astrocytomas and in glioblastomas

12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ccnd2):

	behavior/neurological	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	liver/biliary system	nervous system
reproductive system	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11896535
GO:0019901	protein kinase binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for CCND2 (Your Favorite Gene powered by Ingenuity)

Aryl Hydrocarbon Receptor Signaling
Cell Cycle: G1/S Checkpoint Regulation
Molecular Mechanisms of Cancer
p53 Signaling
IL-8 Signaling

GeneDecks CCND2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CCND2

5/72 Interacting proteins for CCND2 (P30279^{1, 2} ENSP00000261254³) via UniProtKB, MINT, and/or STRING (see all 72 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK4	P11802¹, ENSP00000257904³	EBI-748789, EBI-295644 STRING (score=.999)
CDKN1B	P46527², ENSP00000228872³	MINT-67874 STRING (score=.994)
PCGF2	P35227²	MINT-65936 MINT-65938 MINT-65937 MINT-65935
CDKN1A	P38936²	MINT-2635378
CDK2	ENSP00000266970³	STRING (score=.998)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IEA	--
GO:0001934	positive regulation of protein amino acid phosphorylation	IDA	8114739
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0045737	positive regulation of cyclin-dependent protein kinase activity	IDA	8114739
GO:0051301	cell division	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CCND2

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CCND2
10/11 Novoseek chemical compound relationships for CCND2 gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bromodeoxyuridine	31.83	5	15245432 (3), 15755480 (1), 15379904 (1)
phosphatidylinositol	27.26	4	14660677 (2), 12884287 (1), 17486076 (1)
thymidine	22.54	1	12217398 (1)
tyrosine	8.57	9	10930570 (3), 14990053 (3), 17537993 (1), 11691826 (1)
pd 98,059	4.13	1	10930570 (1)
calcium	2.48	1	9574917 (1)
progesterone	0.80	1	15041725 (1)
forskolin	0.00	1	9658398 (1)
estradiol	0.00	3	9658398 (2)
oligonucleotide	0.00	2	15245432 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCND2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCND2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001759

Sigma-Aldrich siRNA and siRNA Panels for CCND2

Sigma-Aldrich shRNA Panels and shRNA for CCND2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001759

REFSEQ mRNAs for CCND2 gene:

NM_001759.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001759

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001759
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001759
                                 untagged cDNA clone in CMV expression vector: NM_001759

Additional cDNA sequence:

AK223577.1 AK291146.1 BC010958.1 BC014357.1 BC089384.1 BT019847.1 BX647508.1 CR600898.1

D13639.1 M90813.1 X68452.1

16 DOTS entries:

DT.95139513 DT.418769 DT.100027257 DT.97825041 DT.75193426 DT.121197504 DT.70100480 DT.100643619

DT.121197494 DT.121197513 DT.95263984 DT.121197523 DT.121197541 DT.75100426 DT.95177141 DT.95263988

24/470 AceView cDNA sequences (see all 470 ):

BM663326 AW365080 AA327695 H40179 BG287657 AW337771 BP344026 CR600898

AA247822 NM_001759 BQ574704 AA485301 BF172298 X68452 BM720660 BF089595

AI633881 AA885870 BP375742 AA977482 T28541 AI083619 BQ954071 AI650875

highest scoring ESTs for CCND2:

AW026491 D13639 X68452 AA011227 AA136888 AA136999 AA225568 AA322340 AA327873 AA361211

Unigene Cluster for CCND2:

Cyclin D2

Hs.376071 [show with all ESTs]

Unigene Representative Sequence: NM_001759

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000261254

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CCND2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CCND2

¹ / ² / ³

11 probe-sets matching CCND2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73316_at²^{, 3}	U95-E	1	1.00	1.00	0.97	0.88	AW026491	1.00	1.00	1.00	1
36650_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.03	D13639	1.00	1.00	1.00	1
1983_at²^{, 3}	U95-A	2	1.00	0.97	0.49	0.95	X68452	1.00	1.00	1.00	1
84881_at²^{, 3}	U95-D	2	0.69	0.91	0.82	1.16	AI939324	0.60	1.00	0.82	1
200951_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW026491	1.00	1.00	1.00	1
200952_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI635187	0.80	1.00	0.91	1
200953_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001759	0.60	1.00	0.82	1
200951_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200952_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200953_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1565735_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CCND2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: ATATAGTCAG

SOURCE GeneReport for Unigene cluster: Hs.376071
Expression variation in blood from EXPOLDB for CCND2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CCND2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CCND2¹	--	cyclin D2	90.08(n) 94.81(a)	611782 XM_849493.1 XP_854586.1
chimpanzee (Pan troglodytes)	CCND2¹	--	cyclin D2	99.88(n) 100(a)	747123 XM_001156857.1 XP_001156857.1
cow (Bos taurus)	CCND2¹	--	cyclin D2	89.27(n) 94.46(a)	615414 NM_001076372.1 NP_001069840.1
rat (Rattus norvegicus)	Ccnd2¹	--	cyclin D2	88.54(n) 92.71(a)	64033 NM_022267.1 NP_071603.1
mouse (Mus musculus)	Ccnd2^{1, 5}	6 (61.10 cM)⁵	cyclin D2^{1, 5}	89.47(n)¹ 92.36(a)¹	12444¹ NM_009829.3¹ NP_033959.1¹ AF015788⁵ AI256817⁵ (see all 32)

About this table Species with no ortholog for CCND2

ENSEMBL Gene Tree for CCND2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CCND2 gene

CCND3² CCND1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/295 NCBI SNPs in CCND2 are shown (see all 295 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 171)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3217786^1,2	A,C,F,H	4253419(+)	`AAACCC/TTTTTC`	1	--	ut5¹		5	NS EU EA WA	558
	rs1049612^1,2	A,C,F,H	4283023(+)	`GGCCAA/GATCCT`	1	--	ut3¹ ese³		12	NS MN EU EA WA	1442
	rs3217925^1,2	A,C,F,H	4281900(+)	`TTCCCC/TTCCCC`	1	--	ut3¹ ese³ trp³		19	NS EA NA EU WA	1810
	rs3217926^1,2	A,C,F,H	4281944(+)	`GCAGGT/CTTCCT`	1	--	ut3¹ ese³		13	NS NA EA EU WA	1228
	rs1049606^1,2	C,F,H,O	4253297(+)	`GCCTCT/CCTTCT`	1	--	ut5¹ ese³ trp³		6	NS MN EU EA WA	772
	rs3217927^1,2	A,C,F,H	4282065(+)	`CTGCTA/GAGCGG`	1	--	ut3¹ ese³		16	NS NA MN EA EU WA	2640
	rs3217935^1,2	C,F,H	4284983(+)	`GTGCCC/TATGCA`	1	--	ng3¹		3	NS EU WA	406
--	rs3812821^1,2	A,C,F	4252585(+)	`GGGCAG/CAAGGG`	1	--	ng5¹		2	MN EA	376
	rs3217783^1,2	C,F,H	4252860(+)	`GTCGTA/GTTTTG`	1	--	ng5¹		8	NS EU EA WA NA	724
	rs3217923^1,2	C,F,H	4281090(+)	`tttttA/Catttt`	1	--	ut3¹		8	NS EU EA WA NA	716

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HapMap Linkage Disequilibrium images for CCND2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 123833

10/52 Novoseek disease relationships for CCND2 gene (see all 52 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	73.38	17	7784057 (1), 19145199 (1), 17897300 (1), 9103470 (1) (see all 17)
leukemia t-cell	64.64	3	11314046 (1), 15169570 (1)
carcinoma embryonal	55.05	5	12777997 (2), 9056671 (1), 18930031 (1)
tumors	53.48	59	10666388 (3), 14581343 (2), 18661512 (2), 10935479 (2) (see all 39)
seminoma	52.85	4	9056671 (1), 15747581 (1), 14612934 (1)
lymphoma	49.53	17	11291051 (3), 18391076 (1), 16393687 (1), 16424013 (1) (see all 8)
medulloblastoma	47.71	3	12959442 (1), 19164512 (1)
myeloma	47.00	13	18431519 (3), 9565604 (2), 11552984 (1), 19196658 (1) (see all 6)
burkitt lymphoma	43.22	3	8455931 (1), 8045261 (1)
cancer	42.98	22	14581343 (3), 10547574 (3), 7784057 (1), 17270028 (1) (see all 15)

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1 PharmGKB disease relationship for CCND2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

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Human Genome Epidemiology Navigator: CCND2 (8 documents)
Tumor Gene Database: CCND2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/409 PubMed articles for CCND2 gene (see all 409 ):

Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. (PubMed id 1386335)^{1, 2, 3, 4} Inaba T....Look A.T. (1992)
Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines. (PubMed id 8455931)^{1, 3, 4} Palmero I.... Peters G. (1993)
Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. (PubMed id 1386336)^{1, 3, 4} Xiong Y....Ward D.C. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. (PubMed id 15509806)^{1, 3} Fernandez de Mattos S....Lam E.W. (2004)
Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer. (PubMed id 12771922)^{1, 3} Yu J....Sung J.J. (2003)
Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia. (PubMed id 16548914)^{1, 3} Karrman K....Johansson B. (2006)
Glycogen synthase kinase-3beta and p38 phosphorylate cyclin D2 on Thr280 to trigger its ubiquitin/proteasome-dependent degradation in hematopoietic cells. (PubMed id 17486076)^{1, 3} Kida A....Miura O. (2007)
Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation. (PubMed id 14581343)^{1, 3} Padar A....Gazdar A.F. (2003)
Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation. (PubMed id 11289162)^{1, 3} Evron E....Sukumar S. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 894	HGNC: 1583	AceView: CCND2	Ensembl:ENSG00000118971	euGenes: HUgn894
ECgene: CCND2	H-InvDB: CCND2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CCND2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccnd2/

Licensable Technologies for CCND2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CCND2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CCND2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CCND2		Antibodies for CCND2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CCND2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CCND2)
	Antibodies (CCND2)
	Chimera RNAi (CCND2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CCND2 (Cyclin D2)

	Recombinant Proteins (Cyclin D2)
	Antibodies (Cyclin D2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CCND2

	Drugs for CCND2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CCND2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CCND2 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for CCND2

Summaries
for CCND2

Genomic Location
for CCND2

Proteins
for CCND2

Protein Domains/
Families
for CCND2

Gene Function
for CCND2

Pathways & Interactions
for CCND2

Drugs & Compounds
for CCND2

Transcripts
for CCND2

Expression
for CCND2

Orthologs
for CCND2

Paralogs
for CCND2

SNPs/Variants
for CCND2

Disorders & Mutations
for CCND2

Medical News
for CCND2

Publications
for CCND2

Search for CCND2

Genome Databases showing CCND2

Other Databases showing CCND2

Specialized Databases showing CCND2

Licensable Technologies
for CCND2

Services
for CCND2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CCND2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor CCND2

Summariesfor CCND2

Genomic Locationfor CCND2

Proteinsfor CCND2

Protein Domains/Familiesfor CCND2

Gene Functionfor CCND2

Pathways & Interactionsfor CCND2

Drugs & Compoundsfor CCND2

Transcriptsfor CCND2

Expression for CCND2

Orthologsfor CCND2

Paralogsfor CCND2

SNPs/Variantsfor CCND2

Disorders & Mutationsfor CCND2

Medical Newsfor CCND2

Publicationsfor CCND2

Search for CCND2

Genome Databases showing CCND2

Other Databases showing CCND2

Specialized Databases showing CCND2

Licensable Technologiesfor CCND2

Servicesfor CCND2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CCND2

Summaries
for CCND2

Genomic Location
for CCND2

Proteins
for CCND2

Protein Domains/
Families
for CCND2

Gene Function
for CCND2

Pathways & Interactions
for CCND2

Drugs & Compounds
for CCND2

Transcripts
for CCND2

Expression
for CCND2

Orthologs
for CCND2

Paralogs
for CCND2

SNPs/Variants
for CCND2

Disorders & Mutations
for CCND2

Medical News
for CCND2

Publications
for CCND2

Licensable Technologies
for CCND2

Services
for CCND2