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Aliases for CCND1 Gene

Aliases for CCND1 Gene

  • Cyclin D1 2 3
  • PRAD1 3 4 6
  • BCL1 3 4 6
  • B-Cell Lymphoma 1 Protein 3 4
  • B-Cell CLL/Lymphoma 1 2 3
  • BCL-1 Oncogene 3 4
  • PRAD1 Oncogene 3 4
  • Cyclin D1 (PRAD1: Parathyroid Adenomatosis 1) 2
  • Parathyroid Adenomatosis 1 2
  • G1/S-Specific Cyclin D1 2
  • G1/S-Specific Cyclin-D1 3
  • D11S287E 3
  • U21B31 3
  • BCL-1 4

External Ids for CCND1 Gene

Previous HGNC Symbols for CCND1 Gene

  • BCL1
  • D11S287E
  • PRAD1

Previous GeneCards Identifiers for CCND1 Gene

  • GC11P071950
  • GC11P071141
  • GC11P069228
  • GC11P069165
  • GC11P069455
  • GC11P065748

Summaries for CCND1 Gene

Entrez Gene Summary for CCND1 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCND1 Gene

CCND1 (Cyclin D1) is a Protein Coding gene. Diseases associated with CCND1 include multiple myeloma and mantle cell lymphoma. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include protein kinase binding and protein kinase activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCND1 Gene

  • Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Gene Wiki entry for CCND1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCND1 Gene

Genomics for CCND1 Gene

Regulatory Elements for CCND1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCND1 Gene

Start:
69,641,087 bp from pter
End:
69,654,474 bp from pter
Size:
13,388 bases
Orientation:
Plus strand

Genomic View for CCND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCND1 Gene

Proteins for CCND1 Gene

  • Protein details for CCND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24385-CCND1_HUMAN
    Recommended name:
    G1/S-specific cyclin-D1
    Protein Accession:
    P24385
    Secondary Accessions:
    • Q6LEF0

    Protein attributes for CCND1 Gene

    Size:
    295 amino acids
    Molecular mass:
    33729 Da
    Quaternary structure:
    • Interacts with FBXO4 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Interacts with UHRF2; the interaction ubiquitinates CCND1 and appears to occur independently of phosphorylation. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with USP2. Interacts (via cyclin N-terminal domain) with INSM1 (via N-terminal region); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits CDK4 activity. Interacts with CDK4; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression.

    Three dimensional structures from OCA and Proteopedia for CCND1 Gene

neXtProt entry for CCND1 Gene

Proteomics data for CCND1 Gene at MOPED

Post-translational modifications for CCND1 Gene

  • Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.
  • Ubiquitinated, primarily as Lys-48-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286 phosphorylation (By similarity). Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization.
  • Ubiquitination at Lys269
  • Modification sites at PhosphoSitePlus

Other Protein References for CCND1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCND1 (CCND1)

No data available for DME Specific Peptides for CCND1 Gene

Domains for CCND1 Gene

Protein Domains for CCND1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P24385

UniProtKB/Swiss-Prot:

CCND1_HUMAN :
  • P24385
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin D subfamily.
genes like me logo Genes that share domains with CCND1: view

No data available for Gene Families for CCND1 Gene

Function for CCND1 Gene

Molecular function for CCND1 Gene

GENATLAS Biochemistry: cyclin D1,regulator of progression through G1 phase during the cell cycle 1,involved with CDK4 in phosphorylating retinoblastoma protein,STAT5A-regulated transcription,target of activating factor 2 (ATF2) in chondrocytes,overexpressed in parathyroid adenoma,breast (stimulatory effect of estradiol and prolactin),carcinoma,in anaplastic astrocytoma squamous cell carcinoma mantle cell lymphoma (same as BCL1,D11S287E)
UniProtKB/Swiss-Prot Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Gene Ontology (GO) - Molecular Function for CCND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 16569215
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 15232106
GO:0008134 transcription factor binding IPI 16569215
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with CCND1: view
genes like me logo Genes that share phenotypes with CCND1: view

Animal Models for CCND1 Gene

MGI Knock Outs for CCND1:

Animal Model Products

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCND1 Gene

Localization for CCND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCND1 Gene

Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCND1 Gene COMPARTMENTS Subcellular localization image for CCND1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
peroxisome 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CCND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 17420273
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA 11793365
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with CCND1: view

Pathways for CCND1 Gene

genes like me logo Genes that share pathways with CCND1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0000082 G1/S transition of mitotic cell cycle TAS 18483258
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16569215
GO:0000278 mitotic cell cycle TAS --
GO:0000320 re-entry into mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with CCND1: view

Compounds for CCND1 Gene

(1) Drugbank Compounds for CCND1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Arsenic trioxide
  • Acide Arsenieux [French]
1327-53-3 target antagonist

(154) Novoseek inferred chemical compound relationships for CCND1 Gene

Compound -log(P) Hits PubMed IDs
estrogen 70.8 174
flavopiridol 69.3 28
rapamycin 63.2 58
phosphatidylinositol 58 34
curcumin 57 47

(3) PharmGKB related drug/compound annotations for CCND1 Gene

Drug/compound Annotation
cetuximab CA
fluorouracil CA
methotrexate CA
genes like me logo Genes that share compounds with CCND1: view

Transcripts for CCND1 Gene

Unigene Clusters for CCND1 Gene

Cyclin D1:
Representative Sequences:

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCND1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
SP1: - - -
SP2:
SP3: -
SP4: - - - -
SP5: -

Relevant External Links for CCND1 Gene

GeneLoc Exon Structure for
CCND1
ECgene alternative splicing isoforms for
CCND1

Expression for CCND1 Gene

mRNA expression in normal human tissues for CCND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCND1 Gene

SOURCE GeneReport for Unigene cluster for CCND1 Gene Hs.523852

genes like me logo Genes that share expressions with CCND1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCND1 Gene

Orthologs for CCND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCND1 35
  • 91.72 (n)
  • 90.48 (a)
CCND1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCND1 35
  • 92.63 (n)
  • 93.88 (a)
CCND1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCND1 35
  • 91.84 (n)
  • 94.56 (a)
CCND1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnd1 35
  • 90.06 (n)
  • 93.9 (a)
Ccnd1 16
Ccnd1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCND1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCND1 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnd1 35
  • 89.6 (n)
  • 93.9 (a)
chicken
(Gallus gallus)
Aves CCND1 35
  • 78.54 (n)
  • 86.99 (a)
CCND1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCND1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ccnd1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnd1 35
  • 74.94 (n)
  • 78.62 (a)
Str.11367 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9205 35
zebrafish
(Danio rerio)
Actinopterygii ccnd1 35
  • 71.25 (n)
  • 77.32 (a)
ccnd1 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycD 36
  • 23 (a)
OneToMany
CycD 37
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3282 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for CCND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCND1 Gene

ENSEMBL:
Gene Tree for CCND1 (if available)
TreeFam:
Gene Tree for CCND1 (if available)

Paralogs for CCND1 Gene

Paralogs for CCND1 Gene

Selected SIMAP similar genes for CCND1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCND1: view

Variants for CCND1 Gene

Sequence variations from dbSNP and Humsavar for CCND1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7177 -- 69,651,347(+) GCTCC(A/C)CTGAC utr-variant-3-prime
rs9344 other 69,648,142(+) GACCC(A/G)GTAAG synonymous-codon, reference
rs586459 -- 69,646,606(+) CCGAC(C/G)TCCGG intron-variant
rs602652 -- 69,647,874(+) ATACC(A/C/G)AGTGC intron-variant
rs616294 -- 69,644,278(+) AGGCC(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCND1 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV Loss 17160897
nsv825973 CNV Gain 20364138
nsv825974 CNV Gain 20364138
nsv897878 CNV Loss 21882294
esv2675336 CNV Deletion 23128226
nsv897879 CNV Loss 21882294
nsv897880 CNV Loss 21882294
nsv897881 CNV Loss 21882294
nsv897882 CNV Loss 21882294

Relevant External Links for CCND1 Gene

HapMap Linkage Disequilibrium report
CCND1
Human Gene Mutation Database (HGMD)
CCND1

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCND1 Gene

Disorders for CCND1 Gene

(3) OMIM Diseases for CCND1 Gene (168461)

UniProtKB/Swiss-Prot

CCND1_HUMAN
  • Note=A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.
  • Note=A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.
  • Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. {ECO:0000269 PubMed:8695815}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving CCND1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus.

(95) Novoseek inferred disease relationships for CCND1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 90.2 159
tumors 83.3 313
breast cancer 78.5 282
cancer 77.9 176
lymphoma 77 180

Relevant External Links for CCND1

Genetic Association Database (GAD)
CCND1
Human Genome Epidemiology (HuGE) Navigator
CCND1
Tumor Gene Database (TGDB):
CCND1
genes like me logo Genes that share disorders with CCND1: view

Publications for CCND1 Gene

  1. The PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. (PMID: 7687458) Motokura T. … Arnold A. (Genes Chromosomes Cancer 1993) 3 4 23
  2. Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle- cell lymphomas and t(11q13)-associated leukemias. (PMID: 8204893) Rimokh R. … Vuillaume M. (Blood 1994) 3 4 23
  3. Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286. (PMID: 10766840) Germain D. … Hendley J. (J. Biol. Chem. 2000) 3 4 23
  4. Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: a case-control study. (PMID: 11470749) Zheng Y. … Wei Q. (Carcinogenesis 2001) 3 23 48
  5. Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas. (PMID: 11698342) Simpson D.J. … Farrell W.E. (Carcinogenesis 2001) 3 23 48

Products for CCND1 Gene

  • Addgene plasmids for CCND1

Sources for CCND1 Gene

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