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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCND1 Gene

protein-coding   GIFtS: 72
GCID: GC11P069455

Cyclin D1

(Previous name: cyclin D1 (PRAD1: parathyroid adenomatosis 1))
(Previous symbols: BCL1, D11S287E, PRAD1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin D11 2     PRAD1 Oncogene2 3
BCL11 2 3 5     Cyclin D1 (PRAD1: Parathyroid Adenomatosis 1)1
PRAD11 2 3 5     G1/S-Specific Cyclin D11
D11S287E1 2     Parathyroid Adenomatosis 11
B-Cell CLL/Lymphoma 11 2     U21B312
B-Cell Lymphoma 1 Protein2 3     G1/S-Specific Cyclin-D12
BCL-1 Oncogene2 3     BCL-13

External Ids:    HGNC: 15821   Entrez Gene: 5952   Ensembl: ENSG000001100927   OMIM: 1684615   UniProtKB: P243853   

Export aliases for CCND1 gene to outside databases

Previous GC identifers: GC11P071950 GC11P071141 GC11P069704 GC11P069228 GC11P069165 GC11P065748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCND1 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact
with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations,
amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a
variety of tumors and may contribute to tumorigenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCND1 Gene: 
CCND1 (cyclin D1) is a protein-coding gene. Diseases associated with CCND1 include mantle cell lymphoma, and b-cell lymphomas, and among its related super-pathways are Signal transduction AKT signaling and Prolactin Signaling Pathway. GO annotations related to this gene include protein kinase binding and protein kinase activity. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the
retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for
nuclear translocation and activity of the cyclin D-CDK4 complex

Gene Wiki entry for CCND1 (Cyclin D1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCND1 gene promoter:
         AhR   AP-1   ATF-2   Egr-1   STAT5A   Arnt   C/EBPalpha   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCND1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCND1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13

CCND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCND1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P069455:  view genomic region     (about GC identifiers)

Start:
69,455,855 bp from pter      End:
69,469,242 bp from pter
Size:
13,388 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385 (See protein sequence)
Recommended Name: G1/S-specific cyclin-D1  
Size: 295 amino acids; 33729 Da
Subunit: Interacts with FBXO4 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a
serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of
CDK4-mediated kinase activity. Interacts directly with CDKN1B. Interacts with UHRF2; the interaction
ubiquitinates CCND1 and appears to occur independently of phosphorylation. Can form similar complexes with either
CDKN1A or CDKN2A. Interacts with USP2
Subcellular location: Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear
membrane and are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity)
4 PDB 3D structures from and Proteopedia for CCND1:
2W96 (3D)        2W99 (3D)        2W9F (3D)        2W9Z (3D)    
Secondary accessions: Q6LEF0

Explore the universe of human proteins at neXtProt for CCND1: NX_P24385

Explore proteomics data for CCND1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It
    probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein
    ligase complex
  • UniProtKB: Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein)
    ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Following DNA damage it is ubiquitinated by some SCF
    (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286
    phosphorylation (By similarity). Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner.
    Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P24385

  • CCND1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCND1 Protein Expression
    REFSEQ proteins: NP_444284.1  
    ENSEMBL proteins: 
     ENSP00000227507   ENSP00000438482  
    Reactome Protein details: P24385
    Human Recombinant Protein Products for CCND1: 
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    OriGene Protein Over-expression Lysate for CCND1
    OriGene MassSpec for CCND1 
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    Novus Biologicals CCND1 Protein
    Novus Biologicals CCND1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCND1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA17420273
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA11793365
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----

    CCND1 for ontologies           About GeneDecksing



    CCND1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCND1
    R&D Systems Antibodies for CCND1 (Cyclin D1, Cyclin D1/D2)
    Cell Signaling Technology (CST) Antibodies for CCND1 
    OriGene Antibodies for CCND1
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    Novus Biologicals CCND1 Antibodies
    Abcam antibodies for CCND1
    Cloud-Clone Corp. Antibodies for CCND1 
    ThermoFisher Antibody for CCND1
    LSBio Antibodies in human, mouse, rat for CCND1 

    Assay Products for CCND1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCND1 
    Cloud-Clone Corp. CLIAs for CCND1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P24385

    ProtoNet protein and cluster: P24385

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
    Similarity: Belongs to the cyclin family. Cyclin D subfamily
    Similarity: Contains 1 cyclin N-terminal domain


    CCND1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCND1_HUMAN, P24385
    Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the
    retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
    Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
    subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
    Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
    and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
    repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for
    nuclear translocation and activity of the cyclin D-CDK4 complex

         Genatlas biochemistry entry for CCND1:
    cyclin D1,regulator of progression through G1 phase during the cell cycle 1,involved with CDK4 in phosphorylating
    retinoblastoma protein,STAT5A-regulated transcription,target of activating factor 2 (ATF2) in
    chondrocytes,overexpressed in parathyroid adenoma,breast (stimulatory effect of estradiol and
    prolactin),carcinoma,in anaplastic astrocytoma squamous cell carcinoma mantle cell lymphoma (same as
    BCL1,D11S287E)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0005515protein binding IPI15232106
    GO:0016301kinase activity ----
    GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity IEA--
    GO:0019899enzyme binding IPI19412162
         
    CCND1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCND1:
     Decreased viability of wild-ty  Increased cell death in breast 

         15/19 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Ccnd1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  normal  reproductive system 

    CCND1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CCND1: Ccnd1tm1Wbg Ccnd1tm2Phin Ccnd1tm1Dsn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCND1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCND1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCND1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCND1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCND1:
    hsa-mir-106b (MIRT005861), hsa-mir-193b (MIRT000480), hsa-mir-16-1 (MIRT000957), hsa-mir-17 (MIRT005287), hsa-mir-449a (MIRT004679), hsa-mir-15b (MIRT003913), hsa-mir-34a (MIRT001013), hsa-mir-302a (MIRT003637), hsa-mir-15a (MIRT001227), hsa-mir-302c (MIRT005671), hsa-mir-424 (MIRT000941), hsa-mir-16 (MIRT001225), hsa-let-7b (MIRT002484), hsa-mir-20a (MIRT000179), hsa-mir-19a (MIRT003426), hsa-mir-503 (MIRT001105)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCND1
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate CCND1 (see all 109):
    hsa-miR-576-3p hsa-miR-193a-3p hsa-miR-520e hsa-miR-520f hsa-miR-3152-3p hsa-miR-15a hsa-miR-106a hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmidCCND1 3' UTR sequence
    Inhib. RNA
    Products:
        
    EMD Millipore RNAi Products for the Analysis of CCND1 Gene knock-down
    OriGene RNAi products in human, mouse, rat for CCND1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCND1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CCND1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: CCND1 (NM_053056)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCND1 About   (see all 79)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Development Prolactin receptor signaling
    Development Prolactin receptor signaling0.39
    Prolactin signaling pathway0.33
    Leptin signaling pathway0.35
    3Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    4Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.32
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.32
    Cell Cycle Control by BTG Proteins0.36
    5Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/21 EMD Millipore Pathways for CCND1 (see all 21)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription Androgen Receptor nuclear signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Development Prolactin receptor signaling
    Development Thrombopoetin signaling via JAK-STAT pathway

    1 R&D Systems Pathway for CCND1
        Notch Signaling Pathways

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCND1 (see all 21)
        Cell Cycle Control by BTG Proteins
    Androgen Signaling
    IL-10 Pathway
    Molecular Mechanisms of Cancer
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for CCND1
        Cell Cycle / Checkpoint Control

    5/21 GeneGo (Thomson Reuters) Pathways for CCND1 (see all 21)
        Signal transduction AKT signaling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Development Endothelin-1/EDNRA signaling
    Cell cycle Cell cycle (generic schema)
    Development Thrombopoetin signaling via JAK-STAT pathway

    5/32 BioSystems Pathways for CCND1 (see all 32)
        DNA damage response
    Focal Adhesion
    Wnt Signaling Pathway
    G1 to S cell cycle control
    DNA damage response (only ATM dependent)

    1 Sino Biological Pathway for CCND1 
        p53 Pathway

    5/8        Reactome Pathways for CCND1 (see all 8)
        G1 Phase
    Mitotic G1-G1/S phases
    Ubiquitin-dependent degradation of Cyclin D1
    Cell Cycle
    S Phase


    5/28         Kegg Pathways  (Kegg details for CCND1) (see all 28):
        Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Wnt signaling pathway
    Hippo signaling pathway


    CCND1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCND1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/210 Interacting proteins for CCND1 (P243851, 2, 3 ENSP000002275074) via UniProtKB, MINT, STRING, and/or I2D (see all 210)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ----
    GO:0000082G1/S transition of mitotic cell cycle TAS18483258
    GO:0000278mitotic cell cycle TAS--
    GO:0000320re-entry into mitotic cell cycle IEA--
    GO:0001889liver development IEA--

    CCND1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCND1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CCND1

    Browse Tocris compounds for CCND1

    1 DrugBank Compound for CCND1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetantagonist12480548 17005224 16387740 16230390 17370311

    10/154 Novoseek inferred chemical compound relationships for CCND1 gene (see all 154)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 70.8 303 15544931 (6), 20404095 (6), 9039267 (6), 9271411 (5) (see all 99)
    flavopiridol 69.3 29 10493518 (4), 15569374 (2), 18223228 (2), 11956082 (2) (see all 21)
    rapamycin 63.2 77 15753396 (5), 17724476 (4), 11309295 (2), 8999966 (2) (see all 45)
    phosphatidylinositol 58 44 9891068 (4), 19801633 (2), 16123159 (2), 10927622 (1) (see all 29)
    curcumin 57 51 15870875 (6), 15486348 (4), 12483537 (3), 18156803 (3) (see all 33)
    paraffin 56 54 12707028 (2), 16337860 (2), 9831200 (2), 10480344 (2) (see all 44)
    exisulind 55.9 4 12392815 (3), 16382042 (1)
    ly294002 55.3 20 9891068 (2), 10927622 (1), 12242656 (1), 14559232 (1) (see all 16)
    bromodeoxyuridine 53.9 19 8988060 (2), 11260083 (1), 10913198 (1), 19032445 (1) (see all 15)
    progesterone 53.5 126 20404095 (8), 16123159 (3), 15226262 (2), 16844559 (2) (see all 90)

    3 PharmGKB related drug/compound annotations for CCND1 gene    About this table
    Drug/compound PharmGKB Annotation
    cetuximabCA  
    fluorouracilCA  
    methotrexateCA  

    Search CenterWatch for drugs/clinical trials and news about CCND1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCND1 gene: 
    NM_053056.2  

    Unigene Cluster for CCND1:

    Cyclin D1
    Hs.523852  [show with all ESTs]
    Unigene Representative Sequence: NM_053056
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227507(uc001opa.3) ENST00000539241 ENST00000536559 ENST00000535993
    ENST00000545484 ENST00000542367
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCND1
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate CCND1 (see all 109):
    hsa-miR-576-3p hsa-miR-193a-3p hsa-miR-520e hsa-miR-520f hsa-miR-3152-3p hsa-miR-15a hsa-miR-106a hsa-miR-4305
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    Additional mRNA sequence: 

    AB075505.1 AK299044.1 AK313136.1 BC000076.2 BC001501.2 BC014078.2 BC023620.2 BC025302.1 
    BT019844.1 BT019845.1 CR536538.1 CR542099.1 M64349.1 M73554.1 M74092.1 S71637.1 
    X59798.1 

    24/29 DOTS entries (see all 29):

    DT.455928  DT.95276487  DT.97805708  DT.95276453  DT.100856781  DT.100667121  DT.120734257  DT.100058492 
    DT.120734332  DT.120734266  DT.120734335  DT.97846762  DT.100042942  DT.40213212  DT.75132881  DT.86841142 
    DT.120734264  DT.120734273  DT.120734358  DT.80101635  DT.92324759  DT.95276452  DT.95276461  DT.95276478 

    24/690 AceView cDNA sequences (see all 690):

    BM728588 BM670453 AI768962 AI755078 BC014078 CR624763 BG284468 CB136705 
    BM909858 BG056068 CB157625 AU107929 CA437909 BM423522 AI453532 BM914926 
    BM471396 BX335250 BM743283 BE645864 AI659596 AI633564 CB163609 BM715554 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCND1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
    SP1:                                -     -           -                     
    SP2:                                                                        
    SP3:                                                              -         
    SP4:                    -     -     -     -                                 
    SP5:                                                  -                     


    ECgene alternative splicing isoforms for CCND1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCND1 expression in normal human tissues (normalized intensities)      CCND1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGTCTAGA
    CCND1 Expression
    About this image


    CCND1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
             Septum   
     
     Kidney (Urinary System)    fully expand to see all 10 entries
             Proximal Tubule Cells Proximal Tubule
             Proximal Tubule
             visceral organ/metanephros/calyx   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             skeleton/cranium/viscerocranium   
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             skeleton/cranium/viscerocranium   
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
             Retina
             optic nerve head astrocytes   

    See CCND1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCND1

    SOURCE GeneReport for Unigene cluster: Hs.523852
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCND1 (see all 28): 
              Lung Cancer in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCND1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnd11 , 5 cyclin D11, 5 90.06(n)1
    93.9(a)1
      7 (88.92 cM)5
    124431  NM_007631.21  NP_031657.11 
     1449299315 
    chicken
    (Gallus gallus)
    Aves CCND11 cyclin D1 78.54(n)
    86.99(a)
      396341  NM_205381.1  NP_990712.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCND16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    1(55295806-55312819)
    African clawed frog
    (Xenopus laevis)
    Amphibia ccnd1-prov2 cyclin D1 (PRAD1 parathyroid adenomatosis 1) 79.22(n)    BC041525.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnd12 cyclin D1 74.56(n)   30222  AF365874.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycD3 cell proliferation cyclin-dependent
    protein kinase, more
    37(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea cyd-16
    Protein CYD-1
    18(a)
    1 → many
    II(12980591-12993118)


    ENSEMBL Gene Tree for CCND1 (if available)
    TreeFam Gene Tree for CCND1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCND1 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCNA12  
    CCND22  CCNA22  
    3 SIMAP similar genes for CCND1 using alignment to 4 protein entries:     CCND1_HUMAN (see all proteins):
    cyclin D1    CCND2    CCND3

    CCND1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/11 SNPs in CCND1 are shown (see all 11)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs19441291,2
    C,F--69329216(-) ATCCCA/GGGCGC 1 -- us2k114Minor allele frequency- G:0.40NA EA WA CSA 733
    rs362250711,2
    C--69329223(+) GGATGC/GGGGGG 1 -- us2k10--------
    rs1402640331,2
    --69329246(+) CTGGAC/TCCAGA 1 -- us2k10--------
    rs362250671,2
    C,F--69329266(+) GCCGGA/CGTGGG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs362250681,2
    C--69329269(+) GGAGTG/TGGCGA 1 -- us2k10--------
    rs1840119131,2
    --69329325(+) CGCCTC/TGGGCT 1 -- us2k10--------
    rs362250691,2
    C--69329417(+) CATCCA/TGGCGG 1 -- us2k10--------
    rs362250701,2
    C--69329453(+) AAAAAC/GCAGCT 1 -- us2k10--------
    rs362250721,2
    C--69453940(+) GGGGGG/-TGAAG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs719505961,2
    ----69342895(+) CACAC-/ACA   
       CACAC
    ACACA
    1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCND1 (69455855 - 69469242 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CCND1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675336CNV Deletion23128226
    nsv897880CNV Loss21882294
    nsv897878CNV Loss21882294
    dgv16n68CNV Loss17160897
    nsv897882CNV Loss21882294
    nsv897879CNV Loss21882294
    nsv897881CNV Loss21882294
    nsv825973CNV Gain20364138
    nsv825974CNV Gain20364138


    Human Gene Mutation Database (HGMD): CCND1
    SABiosciences Cancer Mutation PCR Assays
    4 SABiosciences qBiomarker Copy Number PCR Arrays containing CCND1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing CCND1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCND1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 168461   
    OMIM disorders: 114500  193300  
    UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
  • Note=A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly
    mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1
    may be oncogenic by directly altering progression through the cell cycle
  • Note=A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation
    t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer
  • Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow
    and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and
    anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord
    compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high
    prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of
    diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=The gene
    represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving CCND1 is found
    in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus

  • 20/227 diseases for CCND1 (see all 227):    About MalaCards
    mantle cell lymphoma    b-cell lymphomas    breast papillary carcinoma    b-cell chronic lymphocytic leukemia
    superficial urinary bladder cancer    papillary carcinoma    extramedullary plasmacytoma    ethmoid sinus adenocarcinoma
    ethmoid sinusitis    periampullary adenocarcinoma    esophagus adenocarcinoma    gastrointestinal lymphoma
    rectosigmoid cancer    endometrial stromal tumor    parathyroid carcinoma    thymic hyperplasia
    pleomorphic adenoma carcinoma    superficial spreading melanoma    laryngeal squamous cell carcinoma    plasma cell leukemia

    18 diseases from the University of Copenhagen DISEASES database for CCND1:
    Retinoblastoma     Lymphoma     Carcinoma     Breast cancer
    Colorectal cancer     Leukemia     Hepatocellular carcinoma     Multiple myeloma
    Lung cancer     Adenoma     Esophageal cancer     Prostate cancer
    Pancreatic cancer     Melanoma     Urinary bladder cancer     Ductal carcinoma in situ
    Malignant glioma     Laryngeal carcinoma

    CCND1 for disorders           About GeneDecksing

    10/95 Novoseek inferred disease relationships for CCND1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 90.2 389 19919588 (6), 11286838 (5), 9497916 (5), 15509364 (4) (see all 99)
    tumors 83.3 1603 10205781 (7), 17631760 (6), 10329035 (6), 15545188 (5) (see all 99)
    breast cancer 78.5 647 17653856 (6), 17626745 (5), 20372799 (5), 9747885 (5) (see all 99)
    cancer 77.9 487 18498074 (6), 12899785 (5), 16732330 (4), 19415697 (4) (see all 99)
    lymphoma 77 407 7540362 (5), 12591969 (5), 11159766 (4), 11291051 (3) (see all 99)
    carcinoma squamous cell 76.6 276 10766394 (6), 17067457 (5), 9816282 (4), 11870667 (3) (see all 99)
    lymphoma mantle-cell 75.1 20 20062012 (2), 9846986 (2), 8204893 (2), 7772515 (1) (see all 13)
    lymphoma small lymphocytic 71.2 12 9556424 (2), 11697516 (1), 9652725 (1), 10319380 (1) (see all 9)
    lymphoma b-cell 70.7 56 18343791 (3), 7540362 (2), 14654791 (2), 7918073 (2) (see all 43)
    carcinoma 69.6 311 17374259 (5), 15354413 (4), 18047954 (4), 17631760 (4) (see all 99)

    Genetic Association Database (GAD): CCND1
    Human Genome Epidemiology (HuGE) Navigator: CCND1 (187 documents)
    Tumor Gene Database (TGDB): CCND1

    Export disorders for CCND1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCND1 gene, integrated from 9 sources (see all 3896):
    (articles sorted by number of sources associating them with CCND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cyclin encoded by a bcl1-linked candidate oncogene. (PubMed id 1826542)1, 2, 3, 9 Motokura T.... Arnold A. (1991)
    2. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PubMed id 1833066)1, 2, 3 Lew D.J.... Reed S.I. (1991)
    3. Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas. (PubMed id 11698342)1, 4, 9 Simpson D.J....Farrell W.E. (2001)
    4. Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck. (PubMed id 11696452)1, 4, 9 Holley S.L....Hoban P.R. (2001)
    5. CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma. (PubMed id 18061526)1, 4, 9 Sathyan K.M....Kannan S. (2008)
    6. Polymorphisms of HER2 Ile655Val and cyclin D1 (CCND1) G870A are not associated with breast cancer risk but polymorphic allele of HER2 is associated with nodal metastases. (PubMed id 18237245)1, 4, 9 Naidu R....Taib N.A. (2008)
    7. Suppression of cancer cell growth by promoting cyclin D1 degradation. (PubMed id 19917254)1, 2, 9 Shan J....Gu W. (2009)
    8. Genetic polymorphisms, messenger RNA expression of p53, p21, and CCND1, and possible links with chromosomal aberrations in Chinese vinyl chloride-exposed workers. (PubMed id 18842998)1, 4, 9 Qiu Y.L....Xia Z.L. (2008)
    9. Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk. (PubMed id 18194538)1, 4, 9 Onay U.V....Ozcelik H. (2008)
    10. Genetic variation in chromosomal translocation breakp oint and immune function genes and risk of non-Hodgkin lymphoma. (PubMed id 20087644)1, 4, 9 Fernberg P....EkstrAPm Smedby K. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 595 HGNC: 1582 AceView: CCND1 Ensembl:ENSG00000110092 euGenes: HUgn595
    ECgene: CCND1 Kegg: 595 H-InvDB: CCND1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCND1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCND1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnd1/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CCND1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCND1 gene:
    Search GeneIP for patents involving CCND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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