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CCND1 Gene

protein-coding   GIFtS: 72
GCID: GC11P069455

Cyclin D1

(Previous name: cyclin D1 (PRAD1: parathyroid adenomatosis 1))
(Previous symbols: BCL1, D11S287E, PRAD1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin D11 2     PRAD1 Oncogene2 3
BCL11 2 3 5     Cyclin D1 (PRAD1: Parathyroid Adenomatosis 1)1
PRAD11 2 3 5     G1/S-Specific Cyclin D11
D11S287E1 2     Parathyroid Adenomatosis 11
B-Cell CLL/Lymphoma 11 2     U21B312
B-Cell Lymphoma 1 Protein2 3     G1/S-Specific Cyclin-D12
BCL-1 Oncogene2 3     BCL-13

External Ids:    HGNC: 15821   Entrez Gene: 5952   Ensembl: ENSG000001100927   OMIM: 1684615   UniProtKB: P243853   

Export aliases for CCND1 gene to outside databases

Previous GC identifers: GC11P071950 GC11P071141 GC11P069704 GC11P069228 GC11P069165 GC11P065748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCND1 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of
CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact
with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations,
amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a
variety of tumors and may contribute to tumorigenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCND1 Gene:
CCND1 (cyclin D1) is a protein-coding gene. Diseases associated with CCND1 include breast papillary carcinoma, and superficial urinary bladder cancer. GO annotations related to this gene include protein kinase binding and protein kinase activity. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the
retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for
nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity
with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner

Gene Wiki entry for CCND1 (Cyclin D1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCND1 gene promoter:
         AhR   AP-1   ATF-2   Egr-1   STAT5A   Arnt   C/EBPalpha   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCND1 promoter sequence
   Search Chromatin IP Primers for CCND1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13

CCND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCND1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P069455:  view genomic region     (about GC identifiers)

Start:
69,455,855 bp from pter      End:
69,469,242 bp from pter
Size:
13,388 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385 (See protein sequence)
Recommended Name: G1/S-specific cyclin-D1  
Size: 295 amino acids; 33729 Da
Subunit: Interacts with FBXO4 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a
serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of
CDK4-mediated kinase activity. Interacts directly with CDKN1B. Interacts with UHRF2; the interaction
ubiquitinates CCND1 and appears to occur independently of phosphorylation. Can form similar complexes with either
CDKN1A or CDKN2A. Interacts with USP2. Interacts (via cyclin N-terminus domain) with INSM1 (via N-terminus
region); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits
CDK4 activity. Interacts with CDK4; the interaction is prevented with the binding of CCND1 to INSM1 during cell
cycle progression
4 PDB 3D structures from and Proteopedia for CCND1:
2W96 (3D)        2W99 (3D)        2W9F (3D)        2W9Z (3D)    
Secondary accessions: Q6LEF0

Explore the universe of human proteins at neXtProt for CCND1: NX_P24385

Explore proteomics data for CCND1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It
    probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein
    ligase complex1
  • Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein)
    ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Following DNA damage it is ubiquitinated by some SCF
    (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286
    phosphorylation (By similarity). Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner.
    Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization1
  • Ubiquitination2 at Lys269
  • Modification sites at PhosphoSitePlus

  • See CCND1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_444284.1  
    ENSEMBL proteins: 
     ENSP00000227507   ENSP00000438482  
    Reactome Protein details: P24385

    CCND1 Human Recombinant Protein Products:

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    Novus Biologicals CCND1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCND1

    CCND1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCND1
    R&D Systems Antibodies for CCND1 (Cyclin D1, Cyclin D1/D2)
    Cell Signaling Technology (CST) Antibodies for CCND1 
    OriGene Antibodies for CCND1
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    Abcam antibodies for CCND1
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    ThermoFisher Antibody for CCND1
    LSBio Antibodies in human, mouse, rat for CCND1

    CCND1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for CCND1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCND1
    Cloud-Clone Corp. CLIAs for CCND1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR015451 Cyclin_D
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P24385

    ProtoNet protein and cluster: P24385

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
    Similarity: Belongs to the cyclin family. Cyclin D subfamily
    Similarity: Contains 1 cyclin N-terminal domain


    CCND1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCND1_HUMAN, P24385
    Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the
    retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
    Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the
    subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.
    Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic
    and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and
    repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for
    nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity
    with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner

         Genatlas biochemistry entry for CCND1:
    cyclin D1,regulator of progression through G1 phase during the cell cycle 1,involved with CDK4 in phosphorylating
    retinoblastoma protein,STAT5A-regulated transcription,target of activating factor 2 (ATF2) in
    chondrocytes,overexpressed in parathyroid adenoma,breast (stimulatory effect of estradiol and
    prolactin),carcinoma,in anaplastic astrocytoma squamous cell carcinoma mantle cell lymphoma (same as
    BCL1,D11S287E)

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IDA16569215
    GO:0004672protein kinase activity IEA--
    GO:0005515protein binding IPI15232106
    GO:0008134transcription factor binding IPI16569215
    GO:0016301kinase activity ----
         
    CCND1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCND1:
     Decreased viability of wild-ty  Increased cell death in breast 

         Selected MGI mutant phenotypes (inferred from 9 alleles(MGI details for Ccnd1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  normal  reproductive system 

    CCND1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CCND1: Ccnd1tm1Wbg Ccnd1tm2Phin Ccnd1tm1Dsn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCND1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCND1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCND1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCND1

    miRNA
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    miRTarBase miRNAs that target CCND1:
    hsa-let-7f-5p (MIRT032092), hsa-mir-425-5p (MIRT016658), hsa-mir-16-1-3p (MIRT000957), hsa-mir-374b-5p (MIRT016061), hsa-mir-34b-3p (MIRT006290), hsa-mir-15b-5p (MIRT003913), hsa-mir-302a-3p (MIRT003637), hsa-mir-520b (MIRT006283), hsa-mir-302c-3p (MIRT005671), hsa-mir-424-5p (MIRT000941), hsa-mir-196a-5p (MIRT048256), hsa-mir-16-5p (MIRT001225), hsa-mir-19a-3p (MIRT003426), hsa-mir-26b-5p (MIRT029483), hsa-mir-106b-5p (MIRT005861), hsa-mir-193b-3p (MIRT000480), hsa-mir-183-5p (MIRT024995), hsa-mir-17-5p (MIRT005287), hsa-mir-365a-3p (MIRT006242), hsa-mir-19b-1-5p (MIRT006276), hsa-mir-449a (MIRT004679), hsa-mir-1 (MIRT023800), hsa-mir-338-3p (MIRT006822), hsa-mir-9-5p (MIRT007372), hsa-mir-34a-5p (MIRT001013), hsa-mir-15a-5p (MIRT001227), hsa-mir-155-5p (MIRT020946), hsa-mir-195-5p (MIRT000225), hsa-let-7b-5p (MIRT002484), hsa-mir-20a-5p (MIRT000179), hsa-mir-92a-3p (MIRT049839), hsa-mir-93-5p (MIRT028002), hsa-mir-503-5p (MIRT001105)

    Block miRNA regulation of human, mouse, rat CCND1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCND1 (see all 109):
    hsa-miR-576-3p hsa-miR-193a-3p hsa-miR-520e hsa-miR-520f hsa-miR-3152-3p hsa-miR-15a hsa-miR-106a hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmidCCND1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCND1

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    GenScript: all cDNA clones in your preferred vector: CCND1 (NM_053056)
    Sino Biological Human cDNA Clone for CCND1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCND1_HUMAN, P24385: Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear
    membrane and are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    peroxisome2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA17420273
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    CCND1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCND1 About   (see all 87)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    2Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Prolactin signaling pathway0.33
    Leptin signaling pathway0.35
    3Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    4Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    G1 Phase0.31
    G1-S Phase Transition0.67
    Cyclin D associated events in G10.31
    Cell Cycle Control by BTG Proteins0.36
    5Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCND1
        Notch Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCND1 (see all 21)
        Cell Cycle Control by BTG Proteins
    Androgen Signaling
    IL-10 Pathway
    Molecular Mechanisms of Cancer
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for CCND1
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CCND1 (see all 21)
        Signal transduction AKT signaling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Development Endothelin-1/EDNRA signaling
    Cell cycle Cell cycle (generic schema)
    Development Thrombopoetin signaling via JAK-STAT pathway

    Selected BioSystems Pathways for CCND1 (see all 33)
        Focal Adhesion
    DNA damage response
    G1 to S cell cycle control
    Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency

    1 Sino Biological Pathway for CCND1
        p53 Pathway

    3 Reactome Pathways for CCND1
        Ubiquitin-dependent degradation of Cyclin D1
    Pre-NOTCH Transcription and Translation
    Cyclin D associated events in G1


    Selected Kegg Pathways  (Kegg details for CCND1) (see all 31):
        FoxO signaling pathway
    Cell cycle
    p53 signaling pathway
    PI3K-Akt signaling pathway
    Wnt signaling pathway


    CCND1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCND1 (see all 28): 
              Lung Cancer in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCND1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCND1 (P243851, 2, 3 ENSP000002275074) via UniProtKB, MINT, STRING, and/or I2D (see all 296)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity ----
    GO:0000082G1/S transition of mitotic cell cycle TAS18483258
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16569215
    GO:0000278mitotic cell cycle TAS--
    GO:0000320re-entry into mitotic cell cycle IEA--

    CCND1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CCND1
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCND1

    1 DrugBank Compound for CCND1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetantagonist12480548 17005224 16387740 16230390 17370311

    Selected Novoseek inferred chemical compound relationships for CCND1 gene (see all 154)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 70.8 303 15544931 (6), 20404095 (6), 9039267 (6), 9271411 (5) (see all 99)
    flavopiridol 69.3 29 10493518 (4), 15569374 (2), 18223228 (2), 11956082 (2) (see all 21)
    rapamycin 63.2 77 15753396 (5), 17724476 (4), 11309295 (2), 8999966 (2) (see all 45)
    phosphatidylinositol 58 44 9891068 (4), 19801633 (2), 16123159 (2), 10927622 (1) (see all 29)
    curcumin 57 51 15870875 (6), 15486348 (4), 12483537 (3), 18156803 (3) (see all 33)
    paraffin 56 54 12707028 (2), 16337860 (2), 9831200 (2), 10480344 (2) (see all 44)
    exisulind 55.9 4 12392815 (3), 16382042 (1)
    ly294002 55.3 20 9891068 (2), 10927622 (1), 12242656 (1), 14559232 (1) (see all 16)
    bromodeoxyuridine 53.9 19 8988060 (2), 11260083 (1), 10913198 (1), 19032445 (1) (see all 15)
    progesterone 53.5 126 20404095 (8), 16123159 (3), 15226262 (2), 16844559 (2) (see all 90)

    3 PharmGKB related drug/compound annotations for CCND1 gene    About this table
    Drug/compound PharmGKB Annotation
    cetuximabCA  
    fluorouracilCA  
    methotrexateCA  



    CCND1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCND1 gene: 
    NM_053056.2  

    Unigene Cluster for CCND1:

    Cyclin D1
    Hs.523852  [show with all ESTs]
    Unigene Representative Sequence: NM_053056
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227507(uc001opa.3) ENST00000539241 ENST00000536559 ENST00000535993
    ENST00000545484 ENST00000542367
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-576-3p hsa-miR-193a-3p hsa-miR-520e hsa-miR-520f hsa-miR-3152-3p hsa-miR-15a hsa-miR-106a hsa-miR-4305
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    OriGene ORF clones in mouse, rat for CCND1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCND1 (NM_053056)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCND1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CCND1
      QuantiFast Probe-based Assays in human, mouse, rat CCND1

    Additional mRNA sequence: 

    AB075505.1 AK299044.1 AK313136.1 BC000076.2 BC001501.2 BC014078.2 BC023620.2 BC025302.1 
    BT019844.1 BT019845.1 CR536538.1 CR542099.1 M64349.1 M73554.1 M74092.1 S71637.1 
    X59798.1 

    Selected DOTS entries (see all 29):

    DT.455928  DT.95276487  DT.97805708  DT.95276453  DT.100856781  DT.100667121  DT.120734257  DT.100058492 
    DT.120734332  DT.120734266  DT.120734335  DT.97846762  DT.100042942  DT.40213212  DT.75132881  DT.86841142 
    DT.120734264  DT.120734273  DT.120734358  DT.80101635  DT.92324759  DT.95276452  DT.95276461  DT.95276478 

    Selected AceView cDNA sequences (see all 690):

    CA437909 BQ000354 BM560475 BM981248 CF129264 CB163609 BF762982 BM840408 
    BM983000 CD672325 BE408935 CR542099 AU119073 BF315611 BQ004942 AU107928 
    BM914926 BM743283 CA434328 AI755078 BQ071276 BX335250 BC014078 BM423522 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCND1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
    SP1:                                -     -           -                     
    SP2:                                                                        
    SP3:                                                              -         
    SP4:                    -     -     -     -                                 
    SP5:                                                  -                     


    ECgene alternative splicing isoforms for CCND1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCND1 expression in normal human tissues (normalized intensities)      CCND1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGTCTAGA
    CCND1 Expression
    About this image


    CCND1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Kidney (Urinary System)    fully expand to see all 9 entries
             Distal Renal Vesicle Cells Renal Vesicle
             Proximal Tubule
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Human embryonic stem cells (family)
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Odontoblasts Dentin
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Cerebellum
    CCND1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCND1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523852
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCND1 (see all 28): 
              Lung Cancer in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CCND1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCND1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnd11 , 5 cyclin D11, 5 90.06(n)1
    93.9(a)1
      7 (88.92 cM)5
    124431  NM_007631.21  NP_031657.11 
     1449299315 
    chicken
    (Gallus gallus)
    Aves CCND11 cyclin D1 78.54(n)
    86.99(a)
      396341  NM_205381.1  NP_990712.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCND16
    cyclin D1
    81(a)
    1 ↔ 1
    1(55295806-55312819)
    African clawed frog
    (Xenopus laevis)
    Amphibia ccnd1-prov2 cyclin D1 (PRAD1 parathyroid adenomatosis 1) 79.22(n)    BC041525.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnd12 cyclin D1 74.56(n)   30222  AF365874.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycD3 cell proliferation cyclin-dependent
    protein kinase, more
    37(a)     --


    ENSEMBL Gene Tree for CCND1 (if available)
    TreeFam Gene Tree for CCND1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCND1 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCNA12  
    CCND22  CCNA22  
    3 SIMAP similar genes for CCND1 using alignment to 4 protein entries:     CCND1_HUMAN (see all proteins):
    cyclin D1    CCND2    CCND3

    CCND1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCND1 (see all 11)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs19441291,2
    C,F--69329216(-) ATCCCA/GGGCGC 1 -- us2k114Minor allele frequency- G:0.40NA EA WA CSA 733
    rs362250711,2
    C--69329223(+) GGATGC/GGGGGG 1 -- us2k10--------
    rs1402640331,2
    --69329246(+) CTGGAC/TCCAGA 1 -- us2k10--------
    rs362250671,2
    C,F--69329266(+) GCCGGA/CGTGGG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs362250681,2
    C--69329269(+) GGAGTG/TGGCGA 1 -- us2k10--------
    rs1840119131,2
    --69329325(+) CGCCTC/TGGGCT 1 -- us2k10--------
    rs362250691,2
    C--69329417(+) CATCCA/TGGCGG 1 -- us2k10--------
    rs362250701,2
    C--69329453(+) AAAAAC/GCAGCT 1 -- us2k10--------
    rs362250721,2
    C--69453940(+) GGGGGG/-TGAAG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs719505961,2
    ----69342895(+) CACAC-/ACA   
       CACAC
    ACACA
    1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCND1 (69455855 - 69469242 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CCND1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675336CNV Deletion23128226
    nsv897880CNV Loss21882294
    nsv897878CNV Loss21882294
    dgv16n68CNV Loss17160897
    nsv897882CNV Loss21882294
    nsv897879CNV Loss21882294
    nsv897881CNV Loss21882294
    nsv825973CNV Gain20364138
    nsv825974CNV Gain20364138

    Human Gene Mutation Database (HGMD): CCND1
    Site Specific Mutation Identification with PCR Assays
    4 Copy Number PCR Panels containing CCND1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing CCND1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCND1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 168461   
    OMIM disorders: 114500  193300  254500  
    UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
  • Note=A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly
    mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1
    may be oncogenic by directly altering progression through the cell cycle
  • Note=A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation
    t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer
  • Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow
    and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and
    anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord
    compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high
    prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of
    diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=The gene
    represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving CCND1 is found
    in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus

  • Selected diseases for CCND1 (see all 232):    About MalaCards
    breast papillary carcinoma    superficial urinary bladder cancer    von hippel-lindau disease, modifier of    colorectal cancer
    mantle cell lymphoma    papillary carcinoma    b-cell lymphomas    ethmoid sinus adenocarcinoma
    ethmoid sinusitis    extramedullary plasmacytoma    b-cell chronic lymphocytic leukemia    laryngeal squamous cell carcinoma
    esophagus adenocarcinoma    periampullary adenocarcinoma    multiple myeloma    gastrointestinal lymphoma
    thymic hyperplasia    pleomorphic adenoma carcinoma    parathyroid carcinoma    laryngeal carcinoma

    18 diseases from the University of Copenhagen DISEASES database for CCND1:
    Retinoblastoma     Lymphoma     Carcinoma     Breast cancer
    Colorectal cancer     Leukemia     Hepatocellular carcinoma     Multiple myeloma
    Lung cancer     Adenoma     Esophageal cancer     Prostate cancer
    Pancreatic cancer     Melanoma     Urinary bladder cancer     Ductal carcinoma in situ
    Malignant glioma     Laryngeal carcinoma

    CCND1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CCND1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 90.2 389 19919588 (6), 11286838 (5), 9497916 (5), 15509364 (4) (see all 99)
    tumors 83.3 1603 10205781 (7), 17631760 (6), 10329035 (6), 15545188 (5) (see all 99)
    breast cancer 78.5 647 17653856 (6), 17626745 (5), 20372799 (5), 9747885 (5) (see all 99)
    cancer 77.9 487 18498074 (6), 12899785 (5), 16732330 (4), 19415697 (4) (see all 99)
    lymphoma 77 407 7540362 (5), 12591969 (5), 11159766 (4), 11291051 (3) (see all 99)
    carcinoma squamous cell 76.6 276 10766394 (6), 17067457 (5), 9816282 (4), 11870667 (3) (see all 99)
    lymphoma mantle-cell 75.1 20 20062012 (2), 9846986 (2), 8204893 (2), 7772515 (1) (see all 13)
    lymphoma small lymphocytic 71.2 12 9556424 (2), 11697516 (1), 9652725 (1), 10319380 (1) (see all 9)
    lymphoma b-cell 70.7 56 18343791 (3), 7540362 (2), 14654791 (2), 7918073 (2) (see all 43)
    carcinoma 69.6 311 17374259 (5), 15354413 (4), 18047954 (4), 17631760 (4) (see all 99)

    Genetic Association Database (GAD): CCND1
    Human Genome Epidemiology (HuGE) Navigator: CCND1 (187 documents)
    Tumor Gene Database (TGDB): CCND1

    Export disorders for CCND1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCND1 gene, integrated from 10 sources (see all 3944):
    (articles sorted by number of sources associating them with CCND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cyclin encoded by a bcl1-linked candidate oncogene. (PubMed id 1826542)1, 2, 3, 9 Motokura T.... Arnold A. (Nature 1991)
    2. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PubMed id 1833066)1, 2, 3 Lew D.J.... Reed S.I. (Cell 1991)
    3. Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas. (PubMed id 11698342)1, 4, 9 Simpson D.J....Farrell W.E. (Carcinogenesis 2001)
    4. Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck. (PubMed id 11696452)1, 4, 9 Holley S.L....Hoban P.R. (Am. J. Pathol. 2001)
    5. CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma. (PubMed id 18061526)1, 4, 9 Sathyan K.M....Kannan S. (Oral Oncol. 2008)
    6. Polymorphisms of HER2 Ile655Val and cyclin D1 (CCND1) G870A are not associated with breast cancer risk but polymorphic allele of HER2 is associated with nodal metastases. (PubMed id 18237245)1, 4, 9 Naidu R....Taib N.A. (Neoplasma 2008)
    7. Suppression of cancer cell growth by promoting cyclin D1 degradation. (PubMed id 19917254)1, 2, 9 Shan J.... Gu W. (Mol. Cell 2009)
    8. Genetic polymorphisms, messenger RNA expression of p53, p21, and CCND1, and possible links with chromosomal aberrations in Chinese vinyl chloride-exposed workers. (PubMed id 18842998)1, 4, 9 Qiu Y.L....Xia Z.L. (amp 2008)
    9. Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk. (PubMed id 18194538)1, 4, 9 Onay U.V....Ozcelik H. (BMC Cancer 2008)
    10. Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma. (PubMed id 20087644)1, 4, 9 Fernberg P....EkstrAPm Smedby K. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 595 HGNC: 1582 AceView: CCND1 Ensembl:ENSG00000110092 euGenes: HUgn595
    ECgene: CCND1 Kegg: 595 H-InvDB: CCND1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCND1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCND1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnd1/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CCND1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCND1 gene:
    Search GeneIP for patents involving CCND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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