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Aliases for CCND1 Gene

Aliases for CCND1 Gene

  • Cyclin D1 2 3 5
  • B-Cell Lymphoma 1 Protein 3 4
  • B-Cell CLL/Lymphoma 1 2 3
  • BCL-1 Oncogene 3 4
  • PRAD1 Oncogene 3 4
  • PRAD1 3 4
  • BCL1 3 4
  • Cyclin D1 (PRAD1: Parathyroid Adenomatosis 1) 2
  • Parathyroid Adenomatosis 1 2
  • G1/S-Specific Cyclin D1 2
  • G1/S-Specific Cyclin-D1 3
  • D11S287E 3
  • U21B31 3
  • BCL-1 4

External Ids for CCND1 Gene

Previous HGNC Symbols for CCND1 Gene

  • BCL1
  • D11S287E
  • PRAD1

Previous GeneCards Identifiers for CCND1 Gene

  • GC11P071950
  • GC11P071141
  • GC11P069704
  • GC11P069228
  • GC11P069165
  • GC11P069455
  • GC11P065748

Summaries for CCND1 Gene

Entrez Gene Summary for CCND1 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCND1 Gene

CCND1 (Cyclin D1) is a Protein Coding gene. Diseases associated with CCND1 include Chronic Lymphocytic Leukemia and Multiple Myeloma. Among its related pathways are Development Ligand-independent activation of ESR1 and ESR2 and Glioma. GO annotations related to this gene include protein kinase activity and enzyme binding. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCND1 Gene

  • Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Gene Wiki entry for CCND1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCND1 Gene

Genomics for CCND1 Gene

Regulatory Elements for CCND1 Gene

Enhancers for CCND1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F069667 0.5 ENCODE 11.2 +26.9 26893 1.6 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 YBX1 ZNF48 SLC30A9 ZNF207 CCND1 MRGPRF-AS1 MRGPRF ORAOV1 ENSG00000281781
GH11F069258 0.6 ENCODE 5.6 -382.5 -382541 1.1 CTCF MTA2 BHLHE40 YBX1 EBF1 EP300 RELA SP1 CBX5 IKZF1 CCND1 GC11M069240 LOC105369368
GH11F069635 0.9 FANTOM5 ENCODE 3.6 +1.4 1379 13.5 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 ZNF143 ORAOV1 CCND1 ENSG00000281781
GH11F069368 0.4 FANTOM5 3.6 -272.8 -272792 0.2 ZFHX2 ZNF518A ZNF781 EGR2 ORAOV1 MYEOV CCND1 GC11P069370 IFITM9P
GH11F069442 1.1 FANTOM5 ENCODE 2.8 -197.1 -197148 3.6 HDGF PKNOX1 CREB3L1 MLX ARID4B DMAP1 YBX1 SLC30A9 CBX5 ZNF143 ENSG00000246889 ORAOV1 CCND1 ENSG00000255606 LOC102724265
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCND1 on UCSC Golden Path with GeneCards custom track

Promoters for CCND1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000564600 -87 5601 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 NFYC JUNB

Genomic Location for CCND1 Gene

Chromosome:
11
Start:
69,641,087 bp from pter
End:
69,654,474 bp from pter
Size:
13,388 bases
Orientation:
Plus strand

Genomic View for CCND1 Gene

Genes around CCND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCND1 Gene

Proteins for CCND1 Gene

  • Protein details for CCND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24385-CCND1_HUMAN
    Recommended name:
    G1/S-specific cyclin-D1
    Protein Accession:
    P24385
    Secondary Accessions:
    • Q6LEF0

    Protein attributes for CCND1 Gene

    Size:
    295 amino acids
    Molecular mass:
    33729 Da
    Quaternary structure:
    • Interacts with FBXO4 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Interacts with UHRF2; the interaction ubiquitinates CCND1 and appears to occur independently of phosphorylation. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with USP2. Interacts (via cyclin N-terminal domain) with INSM1 (via N-terminal region); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits CDK4 activity. Interacts with CDK4; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression.

    Three dimensional structures from OCA and Proteopedia for CCND1 Gene

neXtProt entry for CCND1 Gene

Post-translational modifications for CCND1 Gene

  • Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.
  • Ubiquitinated, primarily as Lys-48-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286 phosphorylation (By similarity). Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization.
  • Ubiquitination at Lys 269
  • Modification sites at PhosphoSitePlus

Other Protein References for CCND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCND1 Gene

Domains & Families for CCND1 Gene

Gene Families for CCND1 Gene

Protein Domains for CCND1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P24385

UniProtKB/Swiss-Prot:

CCND1_HUMAN :
  • Contains 1 cyclin N-terminal domain.
  • Belongs to the cyclin family. Cyclin D subfamily.
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin D subfamily.
genes like me logo Genes that share domains with CCND1: view

Function for CCND1 Gene

Molecular function for CCND1 Gene

GENATLAS Biochemistry:
cyclin D1,regulator of progression through G1 phase during the cell cycle 1,involved with CDK4 in phosphorylating retinoblastoma protein,STAT5A-regulated transcription,target of activating factor 2 (ATF2) in chondrocytes,overexpressed in parathyroid adenoma,breast (stimulatory effect of estradiol and prolactin),carcinoma,in anaplastic astrocytoma squamous cell carcinoma mantle cell lymphoma (same as BCL1,D11S287E)
UniProtKB/Swiss-Prot Function:
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Gene Ontology (GO) - Molecular Function for CCND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 16569215
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 7568034
GO:0008134 transcription factor binding IPI 16569215
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CCND1: view
genes like me logo Genes that share phenotypes with CCND1: view

Human Phenotype Ontology for CCND1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CCND1 Gene

MGI Knock Outs for CCND1:

Animal Model Products

miRNA for CCND1 Gene

miRTarBase miRNAs that target CCND1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCND1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCND1 Gene

Localization for CCND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCND1 Gene

Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCND1 Gene COMPARTMENTS Subcellular localization image for CCND1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
plasma membrane 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA,IDA 8114739
GO:0005622 intracellular IDA --
GO:0005634 nucleus IDA 11793365
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCND1: view

Pathways & Interactions for CCND1 Gene

genes like me logo Genes that share pathways with CCND1: view

SIGNOR curated interactions for CCND1 Gene

Gene Ontology (GO) - Biological Process for CCND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 18483258
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16569215
GO:0000320 re-entry into mitotic cell cycle IEA --
GO:0001889 liver development IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 8114739
genes like me logo Genes that share ontologies with CCND1: view

Drugs & Compounds for CCND1 Gene

(101) Drugs for CCND1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma inhibitor, Target, antagonist 119
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 737
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1791
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1518
Trisenox Approved September 2000 Pharma 0

(66) Additional Compounds for CCND1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) ApexBio Compounds for CCND1 Gene

Compound Action Cas Number
[Ala92]-p16 (84-103) 189064-08-2
CDK4 inhibitor CDK4/Cyclin D1 inhibitor 1256963-02-6
LEE011 succinate hydrate CDK inhibitor 1374639-79-8
NSC 625987 141992-47-4
Ryuvidine 265312-55-8
genes like me logo Genes that share compounds with CCND1: view

Drug Products

Transcripts for CCND1 Gene

Unigene Clusters for CCND1 Gene

Cyclin D1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCND1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCND1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
SP1: - - -
SP2:
SP3: -
SP4: - - - -
SP5: -

Relevant External Links for CCND1 Gene

GeneLoc Exon Structure for
CCND1
ECgene alternative splicing isoforms for
CCND1

Expression for CCND1 Gene

mRNA expression in normal human tissues for CCND1 Gene

Protein differential expression in normal tissues from HIPED for CCND1 Gene

This gene is overexpressed in Lung (28.7), Bone (27.7), and Breast (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCND1 Gene



Protein tissue co-expression partners for CCND1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCND1 Gene:

CCND1

SOURCE GeneReport for Unigene cluster for CCND1 Gene:

Hs.523852
genes like me logo Genes that share expression patterns with CCND1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCND1 Gene

Orthologs for CCND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCND1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCND1 34 35
  • 92.63 (n)
dog
(Canis familiaris)
Mammalia CCND1 34 35
  • 91.84 (n)
chimpanzee
(Pan troglodytes)
Mammalia CCND1 34 35
  • 91.72 (n)
mouse
(Mus musculus)
Mammalia Ccnd1 34 16 35
  • 90.06 (n)
rat
(Rattus norvegicus)
Mammalia Ccnd1 34
  • 89.6 (n)
oppossum
(Monodelphis domestica)
Mammalia CCND1 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCND1 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCND1 34 35
  • 78.54 (n)
lizard
(Anolis carolinensis)
Reptilia CCND1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnd1 34
  • 74.94 (n)
Str.11367 34
African clawed frog
(Xenopus laevis)
Amphibia ccnd1-prov 34
zebrafish
(Danio rerio)
Actinopterygii ccnd1 34 35
  • 71.25 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9205 34
fruit fly
(Drosophila melanogaster)
Insecta CycD 36 35
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3282 34
Species where no ortholog for CCND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCND1 Gene

ENSEMBL:
Gene Tree for CCND1 (if available)
TreeFam:
Gene Tree for CCND1 (if available)

Paralogs for CCND1 Gene

Paralogs for CCND1 Gene

(3) SIMAP similar genes for CCND1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCND1: view

Variants for CCND1 Gene

Sequence variations from dbSNP and Humsavar for CCND1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs9344 other 69,648,142(+) GACCC(A/G)GTAAG reference, synonymous-codon
rs1050971 -- 69,643,220(+) CCGAC(A/G)ACTCC reference, missense
rs1051062 -- 69,653,740(+) GTTAT(A/T)CTTTG utr-variant-3-prime
rs1051357 -- 69,654,377(+) TTGCA(A/C)CGCGG utr-variant-3-prime
rs10640302 -- 69,652,779(+) CAGAT(-/A/AC/ACAC)CACAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCND1 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV loss 17160897
esv2675336 CNV deletion 23128226
nsv1070970 CNV deletion 25765185
nsv1112608 CNV deletion 24896259
nsv555326 CNV loss 21841781
nsv825973 CNV gain 20364138
nsv825974 CNV gain 20364138
nsv951033 CNV deletion 24416366

Variation tolerance for CCND1 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCND1 Gene

Human Gene Mutation Database (HGMD)
CCND1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCND1 Gene

Disorders for CCND1 Gene

MalaCards: The human disease database

(109) MalaCards diseases for CCND1 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
multiple myeloma
  • myeloma, multiple amyloidosis, systemic, included
von hippel-lindau syndrome
  • von hippel-lindau syndrome, modifier of
mantle cell lymphoma
  • lymphocytic choriomeningitis
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CCND1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CCND1_HUMAN
  • Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. {ECO:0000269 PubMed:8695815}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving CCND1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus.
  • Note=A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.
  • Note=A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.

Relevant External Links for CCND1

Genetic Association Database (GAD)
CCND1
Human Genome Epidemiology (HuGE) Navigator
CCND1
Tumor Gene Database (TGDB):
CCND1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCND1
genes like me logo Genes that share disorders with CCND1: view

No data available for Genatlas for CCND1 Gene

Publications for CCND1 Gene

  1. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman C.A. … Press M.F. (BMC Cancer 2009) 3 22 46 64
  2. CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma. (PMID: 18061526) Sathyan K.M. … Kannan S. (Oral Oncol. 2008) 3 22 46 64
  3. Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab. (PMID: 16788380) Zhang W. … Lenz H.J. (Pharmacogenet. Genomics 2006) 3 22 46 64
  4. Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma. (PMID: 16495921) Schernhammer E.S. … Fuchs C.S. (Br. J. Cancer 2006) 3 22 46 64
  5. Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer. (PMID: 12569141) Izzo J.G. … Hittelman W.N. (J. Natl. Cancer Inst. 2003) 3 22 46 64

Products for CCND1 Gene

  • Addgene plasmids for CCND1

Sources for CCND1 Gene

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