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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCND1 Gene

protein-coding   GIFtS: 73
GCID: GC11P069455

cyclin D1

(Previous name: cyclin D1 (PRAD1: parathyroid adenomatosis 1) )
(Previous symbols: BCL1, D11S287E, PRAD1)
 Explore 257 diseases affiliated with
CCND1 via
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 Human Malady Compendium 
Biological research products
for CCND1    

Aliases
for CCND1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin D11 2     BCL-1 Oncogene2 3
BCL11 2 3 5     PRAD1 Oncogene2 3
PRAD11 2 3 5     Cyclin D1 (PRAD1: Parathyroid Adenomatosis 1)1
D11S287E1 2     B-Cell CLL/Lymphoma 12
U21B311 2     G1/S-Specific Cyclin-D12
B-Cell Lymphoma 1 Protein2 3     BCL-13

External Ids:    HGNC: 15821   Entrez Gene: 5952   Ensembl: ENSG000001100927   OMIM: 1684615   UniProtKB: P243853   

Export aliases for CCND1 gene to outside databases

Previous GC identifers: GC11P071950 GC11P071141 GC11P069704 GC11P069228 GC11P069165 GC11P065748


Summaries
for CCND1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCND1:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases.
Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination
of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose
activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor
protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression
of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute
to tumorigenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the
retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent
transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates
RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic
signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its
transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation
and activity of the cyclin D-CDK4 complex

Gene Wiki entry for CCND1 (Cyclin D1)


Genomic Views
for CCND1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCND1 gene promoter:
         AhR   AP-1   ATF-2   Egr-1   STAT5A   Arnt   C/EBPalpha   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CCND1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCND1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13

CCND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCND1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P069455:  view genomic region     (about GC identifiers)

Start:
 69,455,855 bp from pter      End:
 69,469,242 bp from pter
Size:
 13,388 bases      Orientation:
 plus strand

Proteins
for CCND1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385 (See protein sequence)
Recommended Name: G1/S-specific cyclin-D1  
Size: 295 amino acids; 33729 Da
Subunit: Interacts with FBXO4 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a
serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component
of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase
activity. Interacts directly with CDKN1B. Interacts with UHRF2; the interaction ubiquitinates CCND1 and appears to
occur independently of phosphorylation. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with USP2
Subcellular location: Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and
are then translocated to the nucleus through interaction with KIP/CIP family members (By similarity)
4 PDB 3D structures from and Proteopedia for CCND1:
2W96 (3D)        2W99 (3D)        2W9F (3D)        2W9Z (3D)    
Secondary accessions: Q6LEF0

Explore the universe of human proteins at neXtProt for CCND1: NX_P24385

Post-translational modifications:

  • Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It
    • probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase
    complex1
  • Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein)
    • ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Following DNA damage it is ubiquitinated by some SCF
    (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286
    phosphorylation (By similarity). Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner.
    Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P24385

    • CCND1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_444284.1  
    ENSEMBL proteins: 
     ENSP00000227507   ENSP00000438482  
    Reactome Protein details: P24385
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): CCND1
    OriGene Protein Over-expression Lysate: CCND1
    OriGene Custom Protein Services for CCND1 
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    Novus Biologicals CCND1 Protein
    Novus Biologicals CCND1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CCND1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA17420273
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA11793365
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----


    CCND1 for ontologies           About GeneDecksing



    CCND1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCND1
    R&D Systems Antibodies for CCND1 (Cyclin D1, Cyclin D1/D2)
    Cell Signaling Technology (CST) Antibodies for CCND1 
    OriGene Antibodies (see all 4): CCND1
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    GenScript Custom Superior Antibodies Services for CCND1
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    Abcam antibodies for CCND1 
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    ThermoFisher Antibody for CCND1

    Assay Products for CCND1: 
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    GenScript Custom Assay Services for CCND1
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CCND1

    Protein Domains /
    Families
    for CCND1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCND1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P24385

    ProtoNet protein and cluster: P24385

    1 Blocks protein family: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
    Similarity: Belongs to the cyclin family. Cyclin D subfamily
    Similarity: Contains 1 cyclin N-terminal domain


    Function
    for CCND1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
    Function: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the
    retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.
    Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent
    transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates
    RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic
    signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its
    transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation
    and activity of the cyclin D-CDK4 complex

         Genatlas biochemistry entry for CCND1:
    cyclin D1,regulator of progression through G1 phase during the cell cycle 1,involved with CDK4 in phosphorylating
    retinoblastoma protein,STAT5A-regulated transcription,target of activating factor 2 (ATF2) in
    chondrocytes,overexpressed in parathyroid adenoma,breast (stimulatory effect of estradiol and prolactin),carcinoma,in
    anaplastic astrocytoma squamous cell carcinoma mantle cell lymphoma (same as BCL1,D11S287E)

    miRNA
    Products:            		miRTarBase miRNAs that target CCND1:
    hsa-mir-106b (MIRT005861), hsa-mir-193b (MIRT000480), hsa-mir-16-1 (MIRT000957), hsa-mir-17 (MIRT005287), hsa-mir-449a (MIRT004679), hsa-mir-15b (MIRT003913), hsa-mir-34a (MIRT001013), hsa-mir-302a (MIRT003637), hsa-mir-15a (MIRT001227), hsa-mir-302c (MIRT005671), hsa-mir-424 (MIRT000941), hsa-mir-16 (MIRT001225), hsa-let-7b (MIRT002484), hsa-mir-20a (MIRT000179), hsa-mir-19a (MIRT003426), hsa-mir-503 (MIRT001105)

    OriGene 3'-UTR Clone: CCND1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCND1
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate CCND1 (see all 109):
    hsa-miR-576-3p hsa-miR-193a-3p hsa-miR-520e hsa-miR-520f hsa-miR-3152-3p hsa-miR-15a hsa-miR-106a hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmid: CCND1 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of CCND1 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCND1 (see all 7)
    OriGene shRNA RFP: CCND1
    OriGene siRNA: CCND1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCND1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CCND1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCND1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCND1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CCND1 (NM_053056)
    Sino Biological Human cDNA Clone for CCND1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCND1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CCND1
    Search LifeMap BioReagents cell lines for CCND1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0016301kinase activity ----
    GO:0016538cyclin-dependent protein kinase regulator activity IEA--
    GO:0019899enzyme binding IPI19412162


    CCND1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CCND1:
     Decreased viability of wild-ty  Increased cell death in breast 

    Animal Models:
         Mouse knock-outs for CCND1: Ccnd1tm1Wbg Ccnd1tm2Phin Ccnd1tm1Dsn
         15/19 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Ccnd1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  normal  reproductive system 

    CCND1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCND1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/73 super-pathways (see all 73) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cyclins and Cell Cycle Regulation
    		Cyclins and Cell Cycle Regulation1.00
    		Cyclin D associated events in G10.32
    		G1-S Phase Transition0.67
    		G1 Phase0.32
    		Cell Cycle Control by BTG Proteins0.36
    2Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt signaling pathway0.30
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt Signaling Pathway NetPath0.22
    		DNA damage response (only ATM dependent)0.35
    3Glioma
    		Glioma1.00
    		Prostate cancer0.39
    		Non-small cell lung cancer0.53
    		Signaling Pathways in Glioblastoma0.36
    		Melanoma0.43
    4Cell cycle_Cell cycle (generic schema)
    		Cell cycle_Cell cycle (generic schema)1.00
    		Cell cycle_Regulation of G1/S transition (part 2)0.38
    		Cell cycle Cell cycle (generic schema)1.00
    		Cell cycle Regulation of G1/S transition (part 2)0.38
    5Development IGF-RI signaling
    		Development IGF-RI signaling1.00
    		Signal transduction_AKT signaling0.49
    		Development_IGF-1 receptor signaling0.99
    		Signal transduction AKT signaling0.49

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/21 EMD Millipore Pathways for CCND1 (see all 21)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription Androgen Receptor nuclear signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Development Prolactin receptor signaling
    Development Thrombopoetin signaling via JAK-STAT pathway

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCND1 (see all 21)
        Cell Cycle Control by BTG Proteins
    Androgen Signaling
    IL-10 Pathway
    Molecular Mechanisms of Cancer
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for CCND1
        Cell Cycle / Checkpoint Control

    5/21 GeneGo (Thomson Reuters) Pathways for CCND1 (see all 21)
        Signal transduction AKT signaling
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Development Endothelin-1/EDNRA signaling
    Cell cycle Cell cycle (generic schema)
    Development Thrombopoetin signaling via JAK-STAT pathway

    5/31 BioSystems Pathways for CCND1 (see all 31) 
        Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    miRNAs involved in DDR
    G1 to S cell cycle control
    DNA damage response

    5/9        Reactome Pathways for CCND1 (see all 9)
        G1 Phase
    Proteasome mediated degradation of Cyclin D1
    Mitotic G1-G1/S phases
    Ubiquitin-dependent degradation of Cyclin D1
    Cell Cycle


    5/20         Kegg Pathways  (Kegg details for CCND1) (see all 20):
        Cell cycle
    p53 signaling pathway
    Wnt signaling pathway
    Focal adhesion
    Jak-STAT signaling pathway


    CCND1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCND1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/201 Interacting proteins for CCND1 (P243851, 2, 3 ENSP000002275074) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK4P118021, 2, 3, ENSP000002579044EBI-375001,EBI-295644 MINT-50433 I2D: score=11 STRING: ENSP00000257904
    CDKN1BP465271, 3, ENSP000002288724EBI-375001,EBI-519280 I2D: score=7 STRING: ENSP00000228872
    BRCA1P383981, 3, ENSP000003502834EBI-375001,EBI-349905 I2D: score=5 STRING: ENSP00000350283
    ORC4O439292, 3, ENSP000002641694MINT-50436 I2D: score=4 STRING: ENSP00000264169
    UHRF2Q96PU41, 3, ENSP000002768934EBI-375001,EBI-625304 I2D: score=1 STRING: ENSP00000276893
    About this table

    Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080G1 phase of mitotic cell cycle TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS18483258
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000320re-entry into mitotic cell cycle IEA--


    CCND1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCND1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCND1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CCND1

    Browse Tocris compounds for CCND1

    1 DrugBank Compound for CCND1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetantagonist12480548 17005224 16387740 16230390 17370311

    10/154 Novoseek chemical compound relationships for CCND1 gene (see all 154)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 70.8 303 15544931 (6), 20404095 (6), 9039267 (6), 9271411 (5) (see all 99)
    flavopiridol 69.3 29 10493518 (4), 15569374 (2), 18223228 (2), 11956082 (2) (see all 21)
    rapamycin 63.2 77 15753396 (5), 17724476 (4), 11309295 (2), 8999966 (2) (see all 45)
    phosphatidylinositol 58 44 9891068 (4), 19801633 (2), 16123159 (2), 10927622 (1) (see all 29)
    curcumin 57 51 15870875 (6), 15486348 (4), 12483537 (3), 18156803 (3) (see all 33)
    paraffin 56 54 12707028 (2), 16337860 (2), 9831200 (2), 10480344 (2) (see all 44)
    exisulind 55.9 4 12392815 (3), 16382042 (1)
    ly294002 55.3 20 9891068 (2), 10927622 (1), 12242656 (1), 14559232 (1) (see all 16)
    bromodeoxyuridine 53.9 19 8988060 (2), 11260083 (1), 10913198 (1), 19032445 (1) (see all 15)
    progesterone 53.5 126 20404095 (8), 16123159 (3), 15226262 (2), 16844559 (2) (see all 90)

    2 PharmGKB related drug/compound annotations for CCND1 gene
    Drug/compound PharmGKB Annotation
    cetuximabCA  
    methotrexateCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about CCND1 

    Transcripts
    for CCND1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCND1 gene: 
    NM_053056.2  

    Unigene Cluster for CCND1:

    Cyclin D1
    Hs.523852  [show with all ESTs]
    Unigene Representative Sequence: NM_053056
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227507(uc001opa.3) ENST00000539241 ENST00000536559 ENST00000535993
    ENST00000545484 ENST00000542367

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CCND1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCND1
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate CCND1 (see all 109):
    hsa-miR-576-3p hsa-miR-193a-3p hsa-miR-520e hsa-miR-520f hsa-miR-3152-3p hsa-miR-15a hsa-miR-106a hsa-miR-4305
    SwitchGear 3'UTR luciferase reporter plasmid: CCND1 3' UTR sequence
    Inhib. RNA
    Products:             		EMD Millipore RNAi Products for the Analysis of CCND1 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCND1 (see all 7)
    OriGene shRNA RFP: CCND1
    OriGene siRNA: CCND1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCND1
    Clone
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    Additional cDNA sequence: 

    AB075505.1 AK299044.1 AK313136.1 BC000076.2 BC001501.2 BC014078.2 BC023620.2 BC025302.1 
    BT019844.1 BT019845.1 CR536538.1 CR542099.1 M64349.1 M73554.1 M74092.1 S71637.1 
    X59798.1 

    24/30 DOTS entries (see all 30):

    DT.455928  DT.95276487  DT.97805708  DT.95276453  DT.100856781  DT.100667121  DT.120734257  DT.100058492 
    DT.120734332  DT.120734266  DT.120734335  DT.97846762  DT.100042942  DT.40213212  DT.75132881  DT.86841142 
    DT.120734264  DT.120734273  DT.120734358  DT.80101635  DT.92324759  DT.95276452  DT.95276461  DT.95276478 

    24/690 AceView cDNA sequences (see all 690):

    BF764933 BU538773 BM743303 BF762982 CD514813 AI674613 AU119073 CR542099 
    CD672325 BX446447 BQ010133 AA642544 AI633564 BM715554 CB135891 CB117898 
    AL514204 BU509374 BQ685189 BM722271 CR536538 BM423522 BC014078 CR624763 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCND1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6
    SP1:                                -     -           -                     
    SP2:                                                                        
    SP3:                                                              -         
    SP4:                    -     -     -     -                                 
    SP5:                                                  -                     


    ECgene alternative splicing isoforms for CCND1

    Expression
    for CCND1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCND1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGTCTAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCND1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/26 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 26) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod Growth PlateHypertrophic ChondrocytesBone, Cartilage
    BoneCervical VertebraeHypertrophic ChondrocytesBone, Cartilage
    BoneLumbar VertebraeHypertrophic ChondrocytesBone, Cartilage
    BoneSacral VertebraeHypertrophic ChondrocytesBone, Cartilage
    BoneStylopod Growth PlateHypertrophic ChondrocytesBone, Cartilage
    BoneThoracic RibHypertrophic ChondrocytesBone, Cartilage
    BoneThoracic VertebraeHypertrophic ChondrocytesBone, Cartilage
    BoneZeugopod Growth PlateHypertrophic ChondrocytesBone, Cartilage
    EyeNeuroblastic LayerEarly Retinal Progenitor CellsRetina
    EyeNeuroblastic LayerLate Retinal Progenitor CellsRetina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See CCND1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCND1

    SOURCE GeneReport for Unigene cluster: Hs.523852
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCND1 (see all 28): 
              Lung Cancer in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Prostate Cancer in human mouse rat

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    In Situ
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    Orthologs
    for CCND1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCND1 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCND11 cyclin D1 78.54(n)
    86.99(a)    		   396341  NM_205381.1  NP_990712.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CCND16
    		 --
    		 81(a)
    		 1 ↔ 1
    		 1(55295956-55312814)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ccnd1-prov2 cyclin D1 (PRAD1 parathyroid adenomatosis 1) 79.22(n)    BC041525.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ccnd12 cyclin D1 74.56(n)   30222  AF365874.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CycD3 cell proliferation cyclin-dependent protein
    kinase, more    		 37(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea cyd-16
    		 CYclin D family member (cyd-1)
    		 14(a)
    		 1 → many
    		 II(12980522-12993049)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SDS6
    		 cyclin-SDS
    		 7(a)
    		 possible ortholog
    		 1(5079407-5082520)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 cyclin, putative, expressed
    		 10(a)
    		 possible ortholog
    		 3(6555387-6561025)


    ENSEMBL Gene Tree for CCND1 (if available)
    TreeFam Gene Tree for CCND1 (if available) 

    Paralogs
    for CCND1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCND1 gene
    CCND32  CCNO2  CCNE12  CCNB22  CCNE22  CCNB32  CCNB12  CCNA12  
    CCND22  CCNA22  
    3 SIMAP similar genes for CCND1 using alignment to 4 protein entries:     CCND1_HUMAN (see all proteins):
    cyclin D1    CCND2    CCND3

    CCND1 for paralogs           About GeneDecksing



    Genomic Variants
    for CCND1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/305 NCBI SNPs in CCND1 are shown (see all 305)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs362250671,2
    		C,F,--65746469(+) GCCGGA/CGTGGG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs362250681,2
    		C,--65746472(+) GGAGTG/TGGCGA 1 -- us2k10--------
    rs362250691,2
    		C,--65746620(+) CATCCA/TGGCGG 1 -- us2k10--------
    rs362250731,2
    		C,F,--65746760(+) CGTAGG/ATGCTC 2 -- us2k1 ds50011Minor allele frequency- A:0.15WA 118
    rs32128591,2
    		C,F,--65747191(+) TATTGG/TGGACC 2 -- us2k1 ds500111Minor allele frequency- T:0.09NS WA NA 1206
    rs9546181,2
    		C,A--65747194(+) TGGGGA/GCCCTC 2 -- us2k1 ds50012Minor allele frequency- G:0.00NS MN 336
    rs9546191,2
    		C,F,H,--65747218(+) AACACC/TTATCG 2 -- us2k1 spa1 tfbs310Minor allele frequency- T:0.06NS MN NA WA CSA 736
    rs794829631,2
    		F,--65747272(+) TAATTG/TTTCTG 2 -- us2k1 int11Minor allele frequency- T:0.03WA 118
    rs32128601,2
    		C,F,H,--65747591(+) AAGGCA/TGCCCG 2 -- us2k1 int117Minor allele frequency- T:0.06NS EA NA WA CSA 1556
    rs360640481,2
    		C,--65747789(+) CTTGCA/CCAGGG 2 -- us2k1 int14Minor allele frequency- C:0.04NA WA 124

    HapMap Linkage Disequilibrium report for CCND1 (69455855 - 69469242 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CCND1
         1 CNV: 4755
    Human Gene Mutation Database (HGMD): CCND1

    SABiosciences Cancer Mutation PCR Assays
    4 SABiosciences qBiomarker Copy Number PCR Arrays containing CCND1:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    WNT Signaling
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCND1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCND1

    Disorders / Diseases
    for CCND1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCND1 for disorders           About GeneDecksing

    OMIM gene information: 168461   
    OMIM disorders: 114500  193300  
    UniProtKB/Swiss-Prot: CCND1_HUMAN, P24385
  • Note=A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly
    • mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may
    be oncogenic by directly altering progression through the cell cycle
  • Note=A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation
    • t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer
  • Defects in CCND1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells
    • usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia,
    Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and
    spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have
    a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of
    diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal
    aberration involving CCND1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus

    20/257 diseases for CCND1 (see all 257):    About MalaCards
    parathyroid adenomatosis    b-cell lymphomas    von hippel-lindau disease, modification of    von hippel-lindau disease
    acth-secreting pituitary adenoma    marginal zone b-cell lymphoma    estrogen-receptor negative breast cancer    estrogen-receptor positive breast cancer
    splenic marginal zone lymphoma    atypical teratoid rhabdoid tumor    b-cell non-hodgkin lymphoma    squamous cell carcinoma
    superficial spreading melanoma    ethmoid sinusitis    diffuse large b-cell lymphoma    non-hodgkin lymphoma
    familial adenomatous polyposis    superficial urinary bladder cancer    central nervous system lymphoma    extramedullary plasmacytoma

    17 diseases from the University of Copenhagen DISEASES database for CCND1:
    Retinoblastoma     Lymphoma     Carcinoma     Breast cancer
    Colorectal cancer     Leukemia     Hepatocellular carcinoma     Multiple myeloma
    Adenoma     Lung cancer     Esophageal cancer     Prostate cancer
    Melanoma     Pancreatic cancer     Malignant glioma     Ductal carcinoma in situ
    Urinary bladder cancer

    10/95 Novoseek disease relationships for CCND1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 90.2 389 19919588 (6), 11286838 (5), 9497916 (5), 15509364 (4) (see all 99)
    tumors 83.3 1603 10205781 (7), 17631760 (6), 10329035 (6), 15545188 (5) (see all 99)
    breast cancer 78.5 647 17653856 (6), 17626745 (5), 20372799 (5), 9747885 (5) (see all 99)
    cancer 77.9 487 18498074 (6), 12899785 (5), 16732330 (4), 19415697 (4) (see all 99)
    lymphoma 77 407 7540362 (5), 12591969 (5), 11159766 (4), 11291051 (3) (see all 99)
    carcinoma squamous cell 76.6 276 10766394 (6), 17067457 (5), 9816282 (4), 11870667 (3) (see all 99)
    lymphoma mantle-cell 75.1 20 20062012 (2), 9846986 (2), 8204893 (2), 7772515 (1) (see all 13)
    lymphoma small lymphocytic 71.2 12 9556424 (2), 11697516 (1), 9652725 (1), 10319380 (1) (see all 9)
    lymphoma b-cell 70.7 56 18343791 (3), 7540362 (2), 14654791 (2), 7918073 (2) (see all 43)
    carcinoma 69.6 311 17374259 (5), 15354413 (4), 18047954 (4), 17631760 (4) (see all 99)

    Genetic Association Database (GAD): CCND1
    Human Genome Epidemiology (HuGE) Navigator: CCND1 (187 documents)
    Tumor Gene Database (TGDB): CCND1

    Export disorders for CCND1 gene to outside databases

    Publications
    for CCND1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCND1 gene, integrated from 9 sources (see all 3831):
    (articles sorted by number of sources associating them with CCND1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cyclin encoded by a bcl1-linked candidate oncogene. (PubMed id 1826542)1, 2, 3, 9 Motokura T.... Arnold A. (1991)
    2. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PubMed id 1833066)1, 2, 3 Lew D.J.... Reed S.I. (1991)
    3. Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas. (PubMed id 11698342)1, 4, 9 Simpson D.J....Farrell W.E. (2001)
    4. Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck. (PubMed id 11696452)1, 4, 9 Holley S.L....Hoban P.R. (2001)
    5. Suppression of cancer cell growth by promoting cyclin D1 degradation. (PubMed id 19917254)1, 2, 9 Shan J....Gu W. (2009)
    6. Crystal structure of human CDK4 in complex with a D-type cyclin. (PubMed id 19237565)1, 2, 9 Day P.J....Jhoti H. (2009)
    7. Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. (PubMed id 11896626)1, 4, 9 Porter T.R....Maher E.R. (2002)
    8. CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin- dependent kinases that associate with cyclin D1. (PubMed id 8302605)1, 2, 9 Bates S....Peters G. (1994)
    9. Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle- cell lymphomas and t(11q13)-associated leukemias. (PubMed id 8204893)1, 2, 9 Rimokh R.... Vuillaume M. (1994)
    10. Association of cyclin D1 genotype with breast cancer risk and survival. (PubMed id 15668481)1, 4, 9 Shu X.O....Zheng W. (2005)

    External Searches for CCND1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCND1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 595 HGNC: 1582 AceView: CCND1 Ensembl:ENSG00000110092 euGenes: HUgn595
    ECgene: CCND1 Kegg: 595 H-InvDB: CCND1

    Other Databases showing CCND1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCND1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCND1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCND1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnd1/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CCND1

    Intellectual Property
    for CCND1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCND1 gene:
    Search GeneIP for patents involving CCND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCND1
     SwitchGear 3'UTR luciferase reporter plasmids for CCND1
     SwitchGear Promoter luciferase reporter plasmids for CCND1
     ThermoFisher Antibody for CCND1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCND1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
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