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Aliases for CCNC Gene

Aliases for CCNC Gene

  • Cyclin C 2 3 5
  • SRB11 Homolog 3 4
  • HSRB11 3 4
  • CycC 3

External Ids for CCNC Gene

Previous GeneCards Identifiers for CCNC Gene

  • GC06M099858
  • GC06M100006
  • GC06M100035
  • GC06M100037
  • GC06M100096
  • GC06M097430
  • GC06M099990

Summaries for CCNC Gene

Entrez Gene Summary for CCNC Gene

  • The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNC Gene

CCNC (Cyclin C) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNT2.

UniProtKB/Swiss-Prot for CCNC Gene

  • Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Gene Wiki entry for CCNC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNC Gene

Genomics for CCNC Gene

Regulatory Elements for CCNC Gene

Promoters for CCNC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNC on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNC Gene

Chromosome:
6
Start:
99,542,380 bp from pter
End:
99,568,973 bp from pter
Size:
26,594 bases
Orientation:
Minus strand

Genomic View for CCNC Gene

Genes around CCNC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNC Gene

Proteins for CCNC Gene

  • Protein details for CCNC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24863-CCNC_HUMAN
    Recommended name:
    Cyclin-C
    Protein Accession:
    P24863
    Secondary Accessions:
    • B4DPZ1
    • Q9H543

    Protein attributes for CCNC Gene

    Size:
    283 amino acids
    Molecular mass:
    33243 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II.
    SequenceCaution:
    • Sequence=AAC50825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCNC Gene

    Alternative splice isoforms for CCNC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNC Gene

Proteomics data for CCNC Gene at MOPED

Post-translational modifications for CCNC Gene

  • Ubiquitination at Lys 30 and Lys 126
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CCNC Gene

Domains & Families for CCNC Gene

Gene Families for CCNC Gene

Protein Domains for CCNC Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNC Gene

Graphical View of Domain Structure for InterPro Entry

P24863

UniProtKB/Swiss-Prot:

CCNC_HUMAN :
  • Contains 1 cyclin N-terminal domain.
  • Belongs to the cyclin family. Cyclin C subfamily.
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.
genes like me logo Genes that share domains with CCNC: view

Function for CCNC Gene

Molecular function for CCNC Gene

GENATLAS Biochemistry:
cyclin C,regulating S transition of the cell cycle,deleted in a subset of acute lymphoblastic leukemias
UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
genes like me logo Genes that share phenotypes with CCNC: view

Animal Models for CCNC Gene

MGI Knock Outs for CCNC:

Animal Model Products

miRNA for CCNC Gene

miRTarBase miRNAs that target CCNC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNC Gene

Localization for CCNC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNC Gene COMPARTMENTS Subcellular localization image for CCNC gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA --
GO:0016592 mediator complex IEA --
genes like me logo Genes that share ontologies with CCNC: view

Pathways & Interactions for CCNC Gene

genes like me logo Genes that share pathways with CCNC: view

Pathways by source for CCNC Gene

SIGNOR curated interactions for CCNC Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CCNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS --
GO:0007219 Notch signaling pathway TAS --
GO:0010467 gene expression TAS --
GO:0016567 protein ubiquitination IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with CCNC: view

Drugs & Compounds for CCNC Gene

(3) Drugs for CCNC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCNC: view

Transcripts for CCNC Gene

Unigene Clusters for CCNC Gene

Cyclin C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for CCNC Gene

GeneLoc Exon Structure for
CCNC
ECgene alternative splicing isoforms for
CCNC

Expression for CCNC Gene

mRNA expression in normal human tissues for CCNC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNC Gene

This gene is overexpressed in Salivary gland (29.0), Placenta (28.8), and Blymphocyte (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNC Gene



SOURCE GeneReport for Unigene cluster for CCNC Gene Hs.430646

mRNA Expression by UniProt/SwissProt for CCNC Gene

P24863-CCNC_HUMAN
Tissue specificity: Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
genes like me logo Genes that share expression patterns with CCNC: view

Protein tissue co-expression partners for CCNC Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCNC Gene

Orthologs for CCNC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNC 36
  • 100 (a)
OneToOne
CCNC 35
  • 99.76 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CCNC 36
  • 99 (a)
OneToOne
CCNC 35
  • 96.35 (n)
  • 99.29 (a)
dog
(Canis familiaris)
Mammalia CCNC 35
  • 97.06 (n)
  • 99.63 (a)
CCNC 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnc 16
Ccnc 36
  • 99 (a)
OneToOne
Ccnc 35
  • 94.23 (n)
  • 99.29 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNC 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccnc 35
  • 94.82 (n)
  • 99.29 (a)
chicken
(Gallus gallus)
Aves CCNC 36
  • 100 (a)
OneToOne
CCNC 35
  • 90.22 (n)
  • 99.65 (a)
lizard
(Anolis carolinensis)
Reptilia CCNC 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnc 35
  • 85.04 (n)
  • 98.23 (a)
MGC76162 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5368 35
zebrafish
(Danio rerio)
Actinopterygii ccnc 35
  • 76.44 (n)
  • 93.99 (a)
wufj11d06 35
ccnc 36
  • 94 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta CCNC_ANOGA 35
  • 61.61 (n)
  • 68.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycC 36
  • 71 (a)
OneToOne
CycC 35
  • 65.37 (n)
  • 71.98 (a)
CycC 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea H14E04.5 37
  • 34 (a)
cic-1 36
  • 36 (a)
ManyToMany
cic-1 35
  • 49.35 (n)
  • 40.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN8 36
  • 28 (a)
OneToMany
SSN8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G48640 35
  • 54.36 (n)
  • 42.49 (a)
rice
(Oryza sativa)
Liliopsida Os09g0504400 35
  • 53.63 (n)
  • 46.37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4136 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9789 36
  • 62 (a)
OneToOne
Species with no ortholog for CCNC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNC Gene

ENSEMBL:
Gene Tree for CCNC (if available)
TreeFam:
Gene Tree for CCNC (if available)

Paralogs for CCNC Gene

Paralogs for CCNC Gene

genes like me logo Genes that share paralogs with CCNC: view

Variants for CCNC Gene

Structural Variations from Database of Genomic Variants (DGV) for CCNC Gene

Variant ID Type Subtype PubMed ID
nsv886436 CNV Gain 21882294
nsv886438 CNV Gain 21882294
esv267507 CNV Insertion 20981092
nsv823790 CNV Loss 20364138

Variation tolerance for CCNC Gene

Residual Variation Intolerance Score: 38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNC Gene

HapMap Linkage Disequilibrium report
CCNC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CCNC Gene

Disorders for CCNC Gene

Relevant External Links for CCNC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNC

No disorders were found for CCNC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNC Gene

Publications for CCNC Gene

  1. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PMID: 1833066) Lew D.J. … Reed S.I. (Cell 1991) 2 3 4 23 67
  2. Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. (PMID: 19967789) Miyata Y. … Nimer S.D. (Stem Cells 2010) 3 23
  3. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. (PMID: 19047373) Knuesel M.T. … Taatjes D.J. (Mol. Cell. Biol. 2009) 3 23
  4. Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene. (PMID: 19683536) Makkonen K.M. … Carlberg C. (J. Mol. Biol. 2009) 3 23
  5. Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions. (PMID: 17385550) Katona R.L. … Lahti J.M. (Acta. Biol. Hung. 2007) 3 23

Products for CCNC Gene

Sources for CCNC Gene

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