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CCNC Gene

protein-coding   GIFtS: 63
GCID: GC06M099990

Cyclin C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin C1 2
hSRB112 3
SRB11 Homolog2 3
CycC2
cyclin-C2

External Ids:    HGNC: 15811   Entrez Gene: 8922   Ensembl: ENSG000001122377   OMIM: 1238385   UniProtKB: P248633   

Export aliases for CCNC gene to outside databases

Previous GC identifers: GC06M099858 GC06M100006 GC06M100035 GC06M100037 GC06M100096 GC06M097430


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNC Gene:
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with
cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of
RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNC Gene:
CCNC (cyclin C) is a protein-coding gene. Diseases associated with CCNC include fibromatosis, and acute lymphocytic leukemia. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNL2.

UniProtKB/Swiss-Prot: CCNC_HUMAN, P24863
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all
RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates
cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA
polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex

Gene Wiki entry for CCNC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNC gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNC promoter sequence
   Search Chromatin IP Primers for CCNC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q16.2   HGNC cytogenetic band: 6q21

CCNC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNC gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M099990:  view genomic region     (about GC identifiers)

Start:
99,990,256 bp from pter      End:
100,016,849 bp from pter
Size:
26,594 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCNC_HUMAN, P24863 (See protein sequence)
Recommended Name: Cyclin-C  
Size: 283 amino acids; 33243 Da
Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11,
MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26,
MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this
module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or
more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed
by CCNC/CDK8 also associates with the large subunit of RNA polymerase II
Sequence caution: Sequence=AAC50825.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for CCNC (see all 10):
3RGF (3D)        4F6S (3D)        4F6U (3D)        4F6W (3D)        4F70 (3D)        4F7J (3D)    
Secondary accessions: B4DPZ1 Q9H543
Alternative splicing: 2 isoforms:  P24863-1   P24863-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCNC: NX_P24863

Explore proteomics data for CCNC at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys30, Lys126
  • Modification sites at PhosphoSitePlus

  • See CCNC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001013417.1  NP_005181.2  

    ENSEMBL proteins: 
     ENSP00000428982   ENSP00000358222   ENSP00000319027   ENSP00000430381   ENSP00000428577  
     ENSP00000430014   ENSP00000430077   ENSP00000430119   ENSP00000430718   ENSP00000430294  
     ENSP00000427885   ENSP00000428472   ENSP00000417072  
    Reactome Protein details: P24863

    CCNC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCNC
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCNC
    GenScript Custom Purified and Recombinant Proteins Services for CCNC
    Novus Biologicals CCNC Protein
    Novus Biologicals CCNC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNC

    CCNC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies for CCNC
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    Novus Biologicals CCNC Antibodies
    Abcam antibodies for CCNC
    Cloud-Clone Corp. Antibodies for CCNC
    ThermoFisher Antibody for CCNC
    LSBio Antibodies in human, mouse, rat for CCNC

    CCNC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCNC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCNC
    Cloud-Clone Corp. CLIAs for CCNC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR015429 Cyclin_C/H/T/L
     IPR023598 CyclinC

    Graphical View of Domain Structure for InterPro Entry P24863

    ProtoNet protein and cluster: P24863

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNC_HUMAN, P24863
    Similarity: Belongs to the cyclin family. Cyclin C subfamily
    Similarity: Contains 1 cyclin N-terminal domain


    CCNC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNC_HUMAN, P24863
    Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all
    RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific
    regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by
    direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional
    preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates
    cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA
    polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex

         Genatlas biochemistry entry for CCNC:
    cyclin C,regulating S transition of the cell cycle,deleted in a subset of acute lymphoblastic leukemias

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19914168
    GO:0019901protein kinase binding IEA--
         
    CCNC for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CCNC:
     Decreased viability of wild-ty  Increased cell death HMECs cel  Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCNC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNC

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCNC:
    hsa-mir-148b-3p (MIRT019265), hsa-let-7c-5p (MIRT051792)

    Block miRNA regulation of human, mouse, rat CCNC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNC (see all 14):
    hsa-miR-579 hsa-miR-206 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-1 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidCCNC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCNC
    Predesigned siRNA for gene silencing in human, mouse, rat CCNC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCNC

    Clone
    Products:
         
    OriGene clones in human, mouse for CCNC (see all 14)
    OriGene ORF clones in mouse, rat for CCNC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCNC (NM_005190)
    Sino Biological Human cDNA Clone for CCNC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNC

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CCNC
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCNC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNC_HUMAN, P24863: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0016591DNA-directed RNA polymerase II, holoenzyme IEA--
    GO:0016592mediator complex IEA--

    CCNC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNC About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    3Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    4GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    Breast Cancer Regulation by Stathmin10.58
    5Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNC
        Breast Cancer Regulation by Stathmin1
    GADD45 Pathway
    Pancreatic Adenocarcinoma

    1 GeneGo (Thomson Reuters) Pathway for CCNC
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    Selected Reactome Pathways for CCNC (see all 7)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Transcriptional regulation of white adipocyte differentiation
    Generic Transcription Pathway
    PPARA activates gene expression



    CCNC for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CCNC: 
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNC (P248631, 3 ENSP000003582224) via UniProtKB, MINT, STRING, and/or I2D (see all 263)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK8P493361, 3, ENSP000003709384EBI-395261,EBI-394377 I2D: score=13 STRING: ENSP00000370938
    CDK3Q005263, ENSP000004000884I2D: score=2 STRING: ENSP00000400088
    CDK7P506133, ENSP000002564434I2D: score=2 STRING: ENSP00000256443
    MED13LQ71F563, ENSP000002819284I2D: score=2 STRING: ENSP00000281928
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--

    CCNC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNC

    3 Novoseek inferred chemical compound relationships for CCNC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcitriol 46.6 1 10679818 (1)
    vitamin d 15.8 3 11295155 (1)
    zinc 2.68 2 10850412 (1)



    CCNC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCNC gene (2 alternative transcripts): 
    NM_001013399.1  NM_005190.3  

    Unigene Clusters for CCNC:

    Cyclin C
    Hs.430646  [show with all ESTs], Hs.633351  [show with all ESTs]
    Unigene Representative Sequences: BC041123, BM670000
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520429(uc003pqd.3 uc003pqe.3 uc010kcr.3 uc010kcs.3 uc011eah.2)
    ENST00000369220 ENST00000326298 ENST00000520371 ENST00000523961 ENST00000523799
    ENST00000486428 ENST00000523985 ENST00000484049 ENST00000518714 ENST00000524049
    ENST00000519617 ENST00000521017 ENST00000523639 ENST00000369217 ENST00000482541(uc003pqf.3)
    ENST00000523310 ENST00000523541
    miRNA
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    Block miRNA regulation of human, mouse, rat CCNC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNC (see all 14):
    hsa-miR-579 hsa-miR-206 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-1 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidCCNC 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCNC
    Predesigned siRNA for gene silencing in human, mouse, rat CCNC
    Clone
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    OriGene clones in human, mouse for CCNC (see all 14)
    OriGene ORF clones in mouse, rat for CCNC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCNC (NM_005190)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCNC
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNC
      QuantiTect SYBR Green Assays in human, mouse, rat CCNC
      QuantiFast Probe-based Assays in human, mouse, rat CCNC

    Additional mRNA sequence: AK130983.1 

    Selected DOTS entries (see all 31):

    DT.100028106  DT.100823224  DT.92443493  DT.100658993  DT.121316169  DT.95151793  DT.95151787  DT.100756518 
    DT.121316096  DT.91833824  DT.100823221  DT.121315913  DT.91806052  DT.100823220  DT.121315893  DT.121316119 
    DT.75133404  DT.92443501  DT.121315840  DT.121315941  DT.121315945  DT.91996564  DT.92443494  DT.92443498 

    Selected AceView cDNA sequences (see all 355):

    AA451686 AA044021 AA369522 AW513161 BM788069 BP333936 CB138730 BU956329 
    AA877263 BM802853 AA164211 BC050726 BC056153 AU134703 BQ440698 BQ218375 
    BF222002 BQ890014 AI280005 BI755304 BP352353 AB125137 CD514697 AK130983 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCNC (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                    -                       -                 -                                         -               
    SP2:                    -                       -                 -                       -                 -               
    SP3:                    -                       -                 -                       -                 -               
    SP4:                    -                       -                                                                           
    SP5:                                                                                      -                                 


    ECgene alternative splicing isoforms for CCNC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCNC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTATTTA
    CCNC Expression
    About this image


    CCNC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Thyroid (Endocrine System)
     
     Gall Bladder (Hepatobiliary System)
    CCNC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNC Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.430646 Hs.633351

    UniProtKB/Swiss-Prot: CCNC_HUMAN, P24863
    Tissue specificity: Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low
    levels in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including CCNC: 
              Cell Cycle in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCNC
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCNC
    QuantiTect SYBR Green Assays in human, mouse, rat CCNC
    QuantiFast Probe-based Assays in human, mouse, rat CCNC
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNC gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnc1 , 5 cyclin C1, 5 94.23(n)1
    99.29(a)1
      4 (8.86 cM)5
    518131  NM_016746.31  NP_058026.21 
     217277015 
    chicken
    (Gallus gallus)
    Aves CCNC1 cyclin C 90.22(n)
    99.65(a)
      421791  NM_001167765.1  NP_001161237.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNC6
    cyclin C
    99(a)
    1 ↔ 1
    1(171704373-171724246)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC761622 cyclin C 84.75(n)    BC061613.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj11d062 wufj11d06 77.29(n)   335429  AY398320.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycC1 , 3 G1/S transition of mitotic cell cycle
    RNA polymerase more3
    Cyclin C1
    71(a)3
    65.37(n)1
    71.98(a)1
      88D63
    418011  NM_057500.31  NP_476848.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H14E04.53
    cic-11
    cyclin3
    cic-11
    34(a)3
    49.35(n)1
    40.62(a)1
      III(2466220-2473025)3
    1753571  NM_065147.41  NP_497548.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSN8(YNL025C)4 Cyclin-like component of the RNA polymerase II holoenzyme, more   --   14(585291-584320) 855706  NP_014373.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G486401 AT5G48640 54.36(n)
    42.49(a)
      834921  NM_124240.2  NP_199675.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g05044001 Os09g0504400 53.63(n)
    46.37(a)
      9272663  NM_001189000.1  NP_001175929.1 


    ENSEMBL Gene Tree for CCNC (if available)
    TreeFam Gene Tree for CCNC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNC gene
    CCNL22  CCNT22  CCNK2  CCNL12  FAM58A2  CCNT12  

    CCNC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNC (see all 581)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6339891,2
    C,F,A--97458894(+) GCTACG/TCGGGA 2 -- us2k17Minor allele frequency- T:0.27NA WA CSA 11
    rs5605431,2
    C,A--97458895(-) CTCCCG/TAGTAG 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1169013191,2
    F--99989916(+) AGACTG/CAAAAC 2 -- ds50011Minor allele frequency- C:0.01NA 120
    rs566965481,2
    C,F--99989967(+) TAAAGA/CCTATA 2 -- ds50012Minor allele frequency- C:0.10NA EA 240
    rs1384701201,2
    C--99990018(+) AGAGC-/TTTTTT 2 -- ds50010--------
    rs1879384281,2
    --99990048(+) ACCTAC/TATATG 2 -- ds50010--------
    rs1906817971,2
    --99990049(+) CCTATA/GTATGT 2 -- ds50010--------
    rs1833936381,2
    --99990100(+) TGATAC/TGCTCC 2 -- ds50010--------
    rs1879328261,2
    --99990169(+) ACAACC/TTATAA 2 -- ds50010--------
    rs624323471,2
    C,F--99990177(+) TAAAAG/TGCTTT 2 -- ds50015Minor allele frequency- T:0.14NA WA EA 362

    HapMap Linkage Disequilibrium report for CCNC (99990256 - 100016849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCNC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267507CNV Insertion20981092
    nsv823790CNV Loss20364138
    nsv886438CNV Gain21882294
    nsv886436CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNC
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123838    OMIM disorders: --

    Selected diseases for CCNC (see all 29):    
    About MalaCards
    fibromatosis    acute lymphocytic leukemia    noma    sporadic breast cancer
    lymphoblastic leukemia    purpura    thrombocytopenia    retinoblastoma
    colon adenocarcinoma    gingivitis    myelodysplastic syndromes    lateral sclerosis
    amyotrophic lateral sclerosis    breast cancer    inflammatory bowel disease    osteosarcoma
    leukemia    hypertension    hypoxia    myeloid leukemia


    CCNC for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for CCNC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allelic loss 32.7 1 17089020 (1)
    lymphoblastic leukemia acute 32 1 8833152 (1)
    retinoblastoma 26.6 1 17510059 (1)
    tumors 7.82 13 8833152 (2), 11866981 (1), 17089020 (1), 18289462 (1) (see all 6)
    breast cancer 0.817 1 10679818 (1)
    shock 0 3 16387872 (1), 15765783 (1)
    hepatocellular carcinoma 0 1 12679910 (1)
    cancer 0 1 14571772 (1)


    Export disorders for CCNC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNC gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with CCNC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PubMed id 1833066)1, 2, 3, 9 Lew D.J.... Reed S.I. (Cell 1991)
    2. Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. (PubMed id 8833152)1, 2, 9 Li H....Kidd V.J. (Genomics 1996)
    3. The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder. (PubMed id 21806996)1, 2 Schneider E.V....Maskos K. (J. Mol. Biol. 2011)
    4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PubMed id 15175163)1, 2 Sato S.... Conaway R.C. (Mol. Cell 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. TFIIH is negatively regulated by cdk8-containing mediator complexes. (PubMed id 10993082)1, 2 Akoulitchev S.... Reinberg D. (Nature 2000)
    7. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. (PubMed id 10024883)1, 2 Gu W.... Roeder R.G. (Mol. Cell 1999)
    8. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PubMed id 9734358)1, 2 Sun X.... Reinberg D. (Mol. Cell 1998)
    9. Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II. (PubMed id 8700522)1, 2 Rickert P.... Lees E. (Oncogene 1996)
    10. Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. (PubMed id 19967789)1, 9 Miyata Y....Nimer S.D. (Stem Cells 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 892 HGNC: 1581 AceView: CCNC Ensembl:ENSG00000112237 euGenes: HUgn892
    ECgene: CCNC H-InvDB: CCNC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNC gene:
    Search GeneIP for patents involving CCNC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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