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Aliases for CCNC Gene

Aliases for CCNC Gene

  • Cyclin C 2 3
  • SRB11 Homolog 3 4
  • HSRB11 3 4
  • Cyclin-C 3
  • CycC 3

External Ids for CCNC Gene

Previous GeneCards Identifiers for CCNC Gene

  • GC06M099858
  • GC06M100006
  • GC06M100035
  • GC06M100037
  • GC06M100096
  • GC06M097430
  • GC06M099990

Summaries for CCNC Gene

Entrez Gene Summary for CCNC Gene

  • The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNC Gene

CCNC (Cyclin C) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNT1.

UniProtKB/Swiss-Prot for CCNC Gene

  • Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Gene Wiki entry for CCNC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNC Gene

Genomics for CCNC Gene

Regulatory Elements for CCNC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNC Gene

Start:
99,542,380 bp from pter
End:
99,568,973 bp from pter
Size:
26,594 bases
Orientation:
Minus strand

Genomic View for CCNC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNC Gene

Proteins for CCNC Gene

  • Protein details for CCNC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24863-CCNC_HUMAN
    Recommended name:
    Cyclin-C
    Protein Accession:
    P24863
    Secondary Accessions:
    • B4DPZ1
    • Q9H543

    Protein attributes for CCNC Gene

    Size:
    283 amino acids
    Molecular mass:
    33243 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II.
    SequenceCaution:
    • Sequence=AAC50825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCNC Gene

    Alternative splice isoforms for CCNC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNC Gene

Proteomics data for CCNC Gene at MOPED

Post-translational modifications for CCNC Gene

  • Ubiquitination at Lys30 and Lys126
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCNC Gene

Domains for CCNC Gene

Protein Domains for CCNC Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNC Gene

Graphical View of Domain Structure for InterPro Entry

P24863

UniProtKB/Swiss-Prot:

CCNC_HUMAN :
  • P24863
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin C subfamily.
genes like me logo Genes that share domains with CCNC: view

No data available for Gene Families for CCNC Gene

Function for CCNC Gene

Molecular function for CCNC Gene

GENATLAS Biochemistry: cyclin C,regulating S transition of the cell cycle,deleted in a subset of acute lymphoblastic leukemias
UniProtKB/Swiss-Prot Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Gene Ontology (GO) - Molecular Function for CCNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19047373
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNC: view
genes like me logo Genes that share phenotypes with CCNC: view

Animal Model Products

miRNA for CCNC Gene

miRTarBase miRNAs that target CCNC

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCNC Gene

Localization for CCNC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNC Gene COMPARTMENTS Subcellular localization image for CCNC gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016591 DNA-directed RNA polymerase II, holoenzyme --
GO:0016592 mediator complex IEA --
genes like me logo Genes that share ontologies with CCNC: view

Pathways for CCNC Gene

SuperPathways for CCNC Gene

Superpath Contained pathways
1 Loss of Function of SMAD2/3 in Cancer
2 Signaling by NOTCH1 PEST Domain Mutants in Cancer
3 Fatty acid, triacylglycerol, and ketone body metabolism
4 GPCR Pathway
5 Metabolism
genes like me logo Genes that share pathways with CCNC: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CCNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0006351 transcription, DNA-templated TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CCNC: view

Compounds for CCNC Gene

(3) Novoseek inferred chemical compound relationships for CCNC Gene

Compound -log(P) Hits PubMed IDs
calcitriol 46.6 1
vitamin d 15.8 1
zinc 2.68 1
genes like me logo Genes that share compounds with CCNC: view

Transcripts for CCNC Gene

Unigene Clusters for CCNC Gene

Cyclin C:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for CCNC Gene

GeneLoc Exon Structure for
CCNC
ECgene alternative splicing isoforms for
CCNC

Expression for CCNC Gene

mRNA expression in normal human tissues for CCNC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNC Gene

SOURCE GeneReport for Unigene cluster for CCNC Gene Hs.430646

mRNA Expression by UniProt/SwissProt for CCNC Gene

P24863-CCNC_HUMAN
Tissue specificity: Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain
genes like me logo Genes that share expressions with CCNC: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCNC Gene

Orthologs for CCNC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNC 35
  • 99.76 (n)
  • 100 (a)
CCNC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNC 35
  • 96.35 (n)
  • 99.29 (a)
CCNC 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNC 35
  • 97.06 (n)
  • 99.63 (a)
CCNC 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnc 35
  • 94.23 (n)
  • 99.29 (a)
Ccnc 16
Ccnc 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNC 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccnc 35
  • 94.82 (n)
  • 99.29 (a)
chicken
(Gallus gallus)
Aves CCNC 35
  • 90.22 (n)
  • 99.65 (a)
CCNC 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNC 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnc 35
  • 85.04 (n)
  • 98.23 (a)
MGC76162 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5368 35
zebrafish
(Danio rerio)
Actinopterygii ccnc 35
  • 76.44 (n)
  • 93.99 (a)
ccnc 36
  • 94 (a)
OneToOne
wufj11d06 35
African malaria mosquito
(Anopheles gambiae)
Insecta CCNC_ANOGA 35
  • 61.61 (n)
  • 68.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycC 35
  • 65.37 (n)
  • 71.98 (a)
CycC 36
  • 71 (a)
OneToOne
CycC 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea cic-1 35
  • 49.35 (n)
  • 40.62 (a)
cic-1 36
  • 36 (a)
ManyToMany
H14E04.5 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN8 36
  • 28 (a)
OneToMany
SSN8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G48640 35
  • 54.36 (n)
  • 42.49 (a)
rice
(Oryza sativa)
Liliopsida Os09g0504400 35
  • 53.63 (n)
  • 46.37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4136 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9789 36
  • 62 (a)
OneToOne
Species with no ortholog for CCNC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNC Gene

ENSEMBL:
Gene Tree for CCNC (if available)
TreeFam:
Gene Tree for CCNC (if available)

Paralogs for CCNC Gene

Paralogs for CCNC Gene

genes like me logo Genes that share paralogs with CCNC: view

Variants for CCNC Gene

Sequence variations from dbSNP and Humsavar for CCNC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs8366 -- 99,542,809(-) AAAAA(C/T)CATAA utr-variant-3-prime
rs170710 -- 99,547,177(-) ACCAC(A/G)GAGTA intron-variant
rs182791 -- 99,560,213(+) AGAGA(C/T)TTTAA intron-variant
rs330806 -- 99,545,312(-) CTGAG(G/T)GTTGT intron-variant
rs330807 -- 99,545,866(+) GGAAT(G/T)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNC Gene

Variant ID Type Subtype PubMed ID
nsv886436 CNV Gain 21882294
nsv886438 CNV Gain 21882294
esv267507 CNV Insertion 20981092
nsv823790 CNV Loss 20364138

Relevant External Links for CCNC Gene

HapMap Linkage Disequilibrium report
CCNC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNC Gene

Disorders for CCNC Gene

(8) Novoseek inferred disease relationships for CCNC Gene

Disease -log(P) Hits PubMed IDs
allelic loss 32.7 1
lymphoblastic leukemia acute 32 1
retinoblastoma 26.6 1
tumors 7.82 7
breast cancer 0.817 1
genes like me logo Genes that share disorders with CCNC: view

No data available for UniProtKB/Swiss-Prot for CCNC Gene

Publications for CCNC Gene

  1. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PMID: 1833066) Lew D.J. … Reed S.I. (Cell 1991) 2 3 4 23
  2. Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. (PMID: 8833152) Li H. … Kidd V.J. (Genomics 1996) 3 4 23
  3. Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts. (PMID: 7738192) Yoshizumi M. … Lee M.E. (J. Clin. Invest. 1995) 3 23
  4. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. (PMID: 7568034) Tassan J.-P. … Nigg E.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 23
  5. Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). (PMID: 7698009) Demetrick D.J. … Beach D.H. (Cytogenet. Cell Genet. 1995) 3 23

Products for CCNC Gene

  • Addgene plasmids for CCNC

Sources for CCNC Gene

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