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Aliases for CCNB3 Gene

Aliases for CCNB3 Gene

  • Cyclin B3 2 3 5
  • CYCB3 4

External Ids for CCNB3 Gene

Previous GeneCards Identifiers for CCNB3 Gene

  • GC0XP048582
  • GC0XP048040
  • GC0XP048722
  • GC0XP048944
  • GC0XP049860
  • GC0XP049967
  • GC0XP047471

Summaries for CCNB3 Gene

Entrez Gene Summary for CCNB3 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CCNB3 Gene

CCNB3 (Cyclin B3) is a Protein Coding gene. Diseases associated with CCNB3 include Ewing Sarcoma. Among its related pathways are ATM Pathway and Arrhythmogenic right ventricular cardiomyopathy (ARVC). GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNB1.

UniProtKB/Swiss-Prot for CCNB3 Gene

  • Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNB3 Gene

Genomics for CCNB3 Gene

Regulatory Elements for CCNB3 Gene

Enhancers for CCNB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG050203 0.9 ENCODE 0.7 +1.8 1831 1.6 TBP BRCA1 RAD21 RFX5 YY1 ZNF143 RELB ZNF654 ZNF362 USF2 CCNB3 PIR58816
GH0XG050201 0.6 ENCODE 0.7 -0.3 -321 1.7 JUN EP300 FOSL1 JUND ZNF316 MAFF FOS MAFK EMSY AKAP4 CCNB3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNB3 on UCSC Golden Path with GeneCards custom track

Promoters for CCNB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246601 1987 1000 TBP BRCA1 RAD21 RFX5 YY1 RELB ZNF654 ZNF362 USF2 REST

Genomic Location for CCNB3 Gene

Chromosome:
X
Start:
50,202,713 bp from pter
End:
50,351,914 bp from pter
Size:
149,202 bases
Orientation:
Plus strand

Genomic View for CCNB3 Gene

Genes around CCNB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB3 Gene

Proteins for CCNB3 Gene

  • Protein details for CCNB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWL7-CCNB3_HUMAN
    Recommended name:
    G2/mitotic-specific cyclin-B3
    Protein Accession:
    Q8WWL7
    Secondary Accessions:
    • B1AQI5
    • B1AQI6
    • Q96SB5
    • Q96SB6
    • Q96SB7
    • Q9NT38

    Protein attributes for CCNB3 Gene

    Size:
    1395 amino acids
    Molecular mass:
    157916 Da
    Quaternary structure:
    • Interacts with CDK2 kinase.

    Alternative splice isoforms for CCNB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNB3 Gene

Post-translational modifications for CCNB3 Gene

  • Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNB3 Gene

Domains & Families for CCNB3 Gene

Gene Families for CCNB3 Gene

Suggested Antigen Peptide Sequences for CCNB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWL7

UniProtKB/Swiss-Prot:

CCNB3_HUMAN :
  • The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the cyclin family. Cyclin AB subfamily.
Domain:
  • The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNB3: view

Function for CCNB3 Gene

Molecular function for CCNB3 Gene

UniProtKB/Swiss-Prot Function:
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.

Gene Ontology (GO) - Molecular Function for CCNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12185076
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNB3: view
genes like me logo Genes that share phenotypes with CCNB3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCNB3 Gene

Localization for CCNB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNB3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CCNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with CCNB3: view

Pathways & Interactions for CCNB3 Gene

genes like me logo Genes that share pathways with CCNB3: view

Gene Ontology (GO) - Biological Process for CCNB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0007049 cell cycle IEA --
GO:0010389 regulation of G2/M transition of mitotic cell cycle IEA --
GO:0051301 cell division IEA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with CCNB3: view

No data available for SIGNOR curated interactions for CCNB3 Gene

Drugs & Compounds for CCNB3 Gene

No Compound Related Data Available

Transcripts for CCNB3 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:

Relevant External Links for CCNB3 Gene

GeneLoc Exon Structure for
CCNB3
ECgene alternative splicing isoforms for
CCNB3

Expression for CCNB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNB3 Gene

This gene is overexpressed in Testis (x16.7).

Protein differential expression in normal tissues from HIPED for CCNB3 Gene

This gene is overexpressed in Frontal cortex (36.2) and Pancreatic juice (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNB3 Gene



Protein tissue co-expression partners for CCNB3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCNB3 Gene:

CCNB3

SOURCE GeneReport for Unigene cluster for CCNB3 Gene:

Hs.130310

mRNA Expression by UniProt/SwissProt for CCNB3 Gene:

Q8WWL7-CCNB3_HUMAN
Tissue specificity: Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.

Evidence on tissue expression from TISSUES for CCNB3 Gene

  • Intestine(5)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with CCNB3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNB3 Gene

Orthologs for CCNB3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNB3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CCNB3 34 35
  • 71.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNB3 35
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnb3 34
  • 59.65 (n)
mouse
(Mus musculus)
Mammalia Ccnb3 34 16 35
  • 58.12 (n)
cow
(Bos Taurus)
Mammalia CCNB3 35
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNB3 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNB3 35
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNB3 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10800 34
African clawed frog
(Xenopus laevis)
Amphibia ccnb3-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii ccnb3 35
  • 47 (a)
OneToOne
Dr.15486 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2747 34
fruit fly
(Drosophila melanogaster)
Insecta CycB3 36 35
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea cyb-3 35
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB3 35
  • 25 (a)
ManyToMany
CLB6 35
  • 24 (a)
ManyToMany
CLB1 35
  • 23 (a)
ManyToMany
CLB2 35
  • 23 (a)
ManyToMany
CLB4 35
  • 22 (a)
ManyToMany
CLB5 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8934 35
  • 38 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14019 34
Species where no ortholog for CCNB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNB3 Gene

ENSEMBL:
Gene Tree for CCNB3 (if available)
TreeFam:
Gene Tree for CCNB3 (if available)

Paralogs for CCNB3 Gene

Paralogs for CCNB3 Gene

(2) SIMAP similar genes for CCNB3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CCNB3 Gene

genes like me logo Genes that share paralogs with CCNB3: view

Variants for CCNB3 Gene

Sequence variations from dbSNP and Humsavar for CCNB3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036580 A colorectal cancer sample
rs1000057984 -- 50,224,162(+) TTCCT(C/T)CTGCA intron-variant
rs1000270569 -- 50,314,979(+) TCTGC(C/T)AGCTG intron-variant
rs1000333513 -- 50,215,193(+) ACTGT(A/G)TTAGC intron-variant
rs1000403267 -- 50,215,437(+) CATGG(A/G)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNB3 Gene

Variant ID Type Subtype PubMed ID
nsv1125092 CNV duplication 24896259
nsv1152203 CNV duplication 26484159
nsv508771 CNV insertion 20534489

Variation tolerance for CCNB3 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNB3 Gene

Disorders for CCNB3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCNB3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • neuroepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search CCNB3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNB3
genes like me logo Genes that share disorders with CCNB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNB3 Gene

Publications for CCNB3 Gene

  1. Molecular cloning, gene localization, and structure of human cyclin B3. (PMID: 11846420) Lozano J.-C. … Picard A. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 22 64
  2. Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin. (PMID: 12185076) Nguyen T.B. … Koff A. (J. Biol. Chem. 2002) 2 3 4 22 64
  3. Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins. (PMID: 8313904) Gallant P. … Nigg E.A. (EMBO J. 1994) 3 22 64
  4. BCOR-CCNB3 fusions are frequent in undifferentiated sarcomas of male children. (PMID: 25360585) Peters T.L. … Roy A. (Mod. Pathol. 2015) 3 64
  5. Screening of BCOR-CCNB3 sarcoma using immunohistochemistry for CCNB3: A clinicopathological report of three pediatric cases. (PMID: 26037154) Shibayama T. … Haga H. (Pathol. Int. 2015) 3 64

Products for CCNB3 Gene

Sources for CCNB3 Gene

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