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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNB3 Gene

protein-coding   GIFtS: 57
GCID: GC0XP049967

Cyclin B3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin B31 2
G2/Mitotic-Specific Cyclin-B32
CYCB33

External Ids:    HGNC: 187091   Entrez Gene: 854172   Ensembl: ENSG000001470827   OMIM: 3004565   UniProtKB: Q8WWL73   

Export aliases for CCNB3 gene to outside databases

Previous GC identifers: GC0XP048582 GC0XP048040 GC0XP048722 GC0XP048944 GC0XP049860 GC0XP047471


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNB3 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of
cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different
cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of
each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate
with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the
interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for
this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for CCNB3 Gene: 
CCNB3 (cyclin B3) is a protein-coding gene. Diseases associated with CCNB3 include peripheral primitive neuroectodermal tumor, and primitive neuroectodermal tumor, and among its related super-pathways are Cell cycle and DNA damage response. GO annotations related to this gene include protein binding and protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNB3_HUMAN, Q8WWL7
Function: Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an
essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue
specificity suggest that it may be required during early meiotic prophase I




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011638.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNB3 gene promoter:
         POU2F1   POU2F1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   TGIF   POU3F2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CCNB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11

CCNB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNB3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP049967:  view genomic region     (about GC identifiers)

Start:
49,967,364 bp from pter      End:
50,094,913 bp from pter
Size:
127,550 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNB3_HUMAN, Q8WWL7 (See protein sequence)
Recommended Name: G2/mitotic-specific cyclin-B3  
Size: 1395 amino acids; 157916 Da
Subunit: Interacts with CDK2 kinase
Subcellular location: Nucleus
Secondary accessions: B1AQI5 B1AQI6 Q96SB5 Q96SB6 Q96SB7 Q9NT38
Alternative splicing: 3 isoforms:  Q8WWL7-1   Q8WWL7-2   Q8WWL7-3   

Explore the universe of human proteins at neXtProt for CCNB3: NX_Q8WWL7

Explore proteomics data for CCNB3 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of
    CCNB1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WWL7

  • CCNB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNB3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_149020.2  NP_391990.1  

    ENSEMBL proteins: 
     ENSP00000365210   ENSP00000365206   ENSP00000431645   ENSP00000338682   ENSP00000276014  

    Human Recombinant Protein Products for CCNB3: 
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    Cloud-Clone Corp. Proteins for CCNB3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    CCNB3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CCNB3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR015452 Cyclin_B3

    Graphical View of Domain Structure for InterPro Entry Q8WWL7

    ProtoNet protein and cluster: Q8WWL7

    2 Blocks protein domains:
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB006670 Cyclin


    UniProtKB/Swiss-Prot: CCNB3_HUMAN, Q8WWL7
    Domain: The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the
    ubiquitin-proteasome pathway (By similarity)
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily


    CCNB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNB3_HUMAN, Q8WWL7
    Function: Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an
    essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue
    specificity suggest that it may be required during early meiotic prophase I

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12185076
    GO:0019901protein kinase binding IEA--
         
    CCNB3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CCNB3:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability  Increased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNB3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNB3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCNB3 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    3GPCR Pathway
    Pancreatic Adenocarcinoma0.59
    Breast Cancer Regulation by Stathmin10.58
    4Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation0.98
    5Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for CCNB3
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Spindle assembly and chromosome separation
    Meiosis
    Cell cycle Chromosome condensation in prometaphase
    Cell cycle Cell cycle (generic schema)

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNB3 (see all 8)
        14-3-3 and Cell Cycle Regulation
    Calpain Protease Regulates Cellular Mechanics
    DNA Damage Induced 14-3-3Sigma Signaling
    Breast Cancer Regulation by Stathmin1
    ATM Pathway

    4 GeneGo (Thomson Reuters) Pathways for CCNB3
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Chromosome condensation in prometaphase
    Cell cycle Spindle assembly and chromosome separation
    Cell cycle Cell cycle (generic schema)

    2 BioSystems Pathways for CCNB3
        DNA damage response
    Cell cycle


    3         Kegg Pathways  (Kegg details for CCNB3):
        Cell cycle
    p53 signaling pathway
    Progesterone-mediated oocyte maturation


    CCNB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for CCNB3 (Q8WWL71, 2, 3 ENSP000002760144) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249413, ENSP000002669704I2D: score=4 STRING: ENSP00000266970
    ANAPC1ENSP000003391094STRING: ENSP00000339109
    ANAPC10ENSP000003100714STRING: ENSP00000310071
    ANAPC11ENSP000003499574STRING: ENSP00000349957
    ANAPC13ENSP000003469874STRING: ENSP00000346987
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0007126meiosis IEA--
    GO:0010389regulation of G2/M transition of mitotic cell cycle IEA--
    GO:0051301cell division IEA--
    GO:0051726regulation of cell cycle ----

    CCNB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNB3

    Search CenterWatch for drugs/clinical trials and news about CCNB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNB3 gene (3 alternative transcripts): 
    NM_033031.2  NM_033670.2  NM_033671.1  

    Unigene Clusters for CCNB3:

    Cyclin B3
    Hs.130310  [show with all ESTs], Hs.722420  [show with all ESTs], Hs.722421 , Hs.740165
    Unigene Representative Sequences: AJ416458, DB063071, AJ421672, AK292454
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493507 ENST00000491907 ENST00000376042(uc004dox.4) ENST00000376038(uc004doz.3)
    ENST00000476167(uc010njq.3) ENST00000487204(uc004dpa.3) ENST00000348603
    ENST00000276014(uc004doy.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    OriGene ORF clones in mouse, rat for CCNB3
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCNB3 (NM_033670)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNB3

    Additional mRNA sequence: AK292454.1 

    3 DOTS entries:

    DT.75117232  DT.95366441  DT.95312677 

    24/34 AceView cDNA sequences (see all 34):

    AL137550 AI655746 AI733558 BX508495 AL045650 CD105827 AI989710 AJ314764 
    AI962445 AW594177 CD634655 CD634656 CA428593 AJ314765 NM_033671 AJ314766 
    AI637771 AI003521 NM_033670 AI792329 CA428595 AJ416458 AI377267 CD634653 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCNB3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                              
    SP2:                                                                              


    ECgene alternative splicing isoforms for CCNB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNB3 expression in normal human tissues (normalized intensities)      CCNB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATCAACA
    CCNB3 Expression
    About this image


    CCNB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             placenta ; decidual cells   
     
     Fibroblast (Uncategorized)
             skin ; fibroblasts   
     
     Ovary (Reproductive System)
             oocyte   
     
     Testis (Reproductive System)
             testis ; cells in seminiferus ducts   

    See CCNB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNB3

    SOURCE GeneReport for Unigene clusters: Hs.130310 Hs.722420 Hs.722421 Hs.740165

    UniProtKB/Swiss-Prot: CCNB3_HUMAN, Q8WWL7
    Tissue specificity: Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells.
    Weakly or not expressed in other tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CCNB3 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnb31 , 5 cyclin B31, 5 56.48(n)1
    39.56(a)1
      X (3.13 cM)5
    2090911  NM_183015.31  NP_898836.21 
     69796525 
    chicken
    (Gallus gallus)
    Aves CCNB31 cyclin B3 64.42(n)
    58.81(a)
      396167  NM_205239.1  NP_990570.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNB36
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343577.1(130447-147293)
    African clawed frog
    (Xenopus laevis)
    Amphibia ccnb3-A-prov2 cyclin B3 76.65(n)    AJ304990.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.154862 Transcribed sequence with weak similarity to protein more 71.3(n)    BQ074204.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycB33 mitotic spindle assembly
    cyclin-dependent protein more
    47(a)   96B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea cyb-36
    G2/mitotic-specific cyclin-B3
    34(a)
    1 ↔ 1
    V(15395694-15397348)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLB66
    CLB36
    (see all 6)
    B-type cyclin involved in DNA replication during S...
    B-type cyclin involved in cell cycle progression; ...
    (see all 6)
    22(a)
    22(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    VII(705359-706501)
    IV(176773-178056)


    ENSEMBL Gene Tree for CCNB3 (if available)
    TreeFam Gene Tree for CCNB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNB3 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  
    2 SIMAP similar genes for CCNB3 using alignment to 2 protein entries:     CCNB3_HUMAN (see all proteins):
    CCNB2    CCNB1

    CCNB3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCNB3
    PGOHUM00000235169


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/908 SNPs in CCNB3 are shown (see all 908)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365804
    A colorectal cancer sample4--see VAR_0365802 K T mis40--------
    rs1114226411,2
    C,F--50030996(+) TTGCGC/TGCTCC 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1406349341,2
    C--50031231(+) GTCTTC/TCATGA 2 -- int10--------
    rs1872873661,2
    --50037446(+) GTTCCA/GCAGAG 2 -- us2k10--------
    rs1903344221,2
    --50037509(+) CTTCTC/TCCTGG 2 -- us2k10--------
    rs1835386671,2
    C--50038046(+) GCTGGC/TTTAGA 2 -- us2k10--------
    rs1393650201,2
    --50038141(+) GTGATC/TGAAGA 2 -- us2k10--------
    rs2010007791,2
    --50038144(+) ATCGA-/AGAGACT 2 -- us2k10--------
    rs736342341,2
    C,F--50038173(+) CTGCCT/CGGGAA 2 -- us2k11Minor allele frequency- C:0.00WA 2
    rs120098731,2
    C,F,H--50038259(+) agaatT/Cgtacc 2 -- us2k110Minor allele frequency- C:0.07NS EA NA 1096

    HapMap Linkage Disequilibrium report for CCNB3 (49967364 - 50094913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCNB3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508771CNV Insertion20534489


    Locus Specific Mutation Databases (LSDB): CCNB3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300456    OMIM disorders: --

    7 diseases for CCNB3:    About MalaCards
    peripheral primitive neuroectodermal tumor    primitive neuroectodermal tumor    sarcoma    adenocarcinoma
    pancreatitis    breast cancer    neuronitis


    CCNB3 for disorders           About GeneDecksing


    Export disorders for CCNB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNB3 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CCNB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin. (PubMed id 12185076)1, 2, 3, 9 Nguyen T.B.... Koff A. (2002)
    2. Molecular cloning, gene localization, and structure of human cyclin B3. (PubMed id 11846420)1, 2, 3, 9 Lozano J.-C....Picard A. (2002)
    3. Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins. (PubMed id 8313904)1, 9 Gallant P. and Nigg E.A. (1994)
    4. A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion. (PubMed id 22387997)1 Pierron G.... Delattre O. (2012)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Proteomic identification of overexpressed adenomatous polyposis coli and cyclin B3 during endoderm differentiation from human embryo nic stem cells. (PubMed id 21404461)1 Lee D.H....Kim S.K. (2011)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85417 HGNC: 18709 AceView: CCNB3 Ensembl:ENSG00000147082 euGenes: HUgn85417
    ECgene: CCNB3 Kegg: 85417 H-InvDB: CCNB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNB3 gene:
    Search GeneIP for patents involving CCNB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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