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Aliases for CCNB2 Gene

Aliases for CCNB2 Gene

  • Cyclin B2 2 3
  • HsT17299 3

External Ids for CCNB2 Gene

Previous GeneCards Identifiers for CCNB2 Gene

  • GC15P054954
  • GC15P052444
  • GC15P056976
  • GC15P057113
  • GC15P057184
  • GC15P059397
  • GC15P036219

Summaries for CCNB2 Gene

Entrez Gene Summary for CCNB2 Gene

  • Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNB2 Gene

CCNB2 (Cyclin B2) is a Protein Coding gene. Diseases associated with CCNB2 include anauxetic dysplasia and breast cancer. Among its related pathways are GPCR Pathway and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNB2 Gene

  • Essential for the control of the cell cycle at the G2/M (mitosis) transition

Gene Wiki entry for CCNB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNB2 Gene

Genomics for CCNB2 Gene

Regulatory Elements for CCNB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNB2 Gene

Chromosome:
15
Start:
59,105,078 bp from pter
End:
59,125,045 bp from pter
Size:
19,968 bases
Orientation:
Plus strand

Genomic View for CCNB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB2 Gene

Proteins for CCNB2 Gene

  • Protein details for CCNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95067-CCNB2_HUMAN
    Recommended name:
    G2/mitotic-specific cyclin-B2
    Protein Accession:
    O95067
    Secondary Accessions:
    • B3KM93
    • Q6FI99

    Protein attributes for CCNB2 Gene

    Size:
    398 amino acids
    Molecular mass:
    45282 Da
    Quaternary structure:
    • Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex

neXtProt entry for CCNB2 Gene

Proteomics data for CCNB2 Gene at MOPED

Post-translational modifications for CCNB2 Gene

  • Ubiquitination at Lys 328, Lys 360, and Lys 367
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCNB2 Gene

Domains & Families for CCNB2 Gene

Gene Families for CCNB2 Gene

Protein Domains for CCNB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95067

UniProtKB/Swiss-Prot:

CCNB2_HUMAN :
  • Belongs to the cyclin family. Cyclin AB subfamily.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNB2: view

Function for CCNB2 Gene

Molecular function for CCNB2 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition

Gene Ontology (GO) - Molecular Function for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15232106
genes like me logo Genes that share ontologies with CCNB2: view
genes like me logo Genes that share phenotypes with CCNB2: view

Animal Models for CCNB2 Gene

MGI Knock Outs for CCNB2:

miRNA for CCNB2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCNB2 Gene

Localization for CCNB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNB2 Gene COMPARTMENTS Subcellular localization image for CCNB2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with CCNB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNB2 Gene

Pathways & Interactions for CCNB2 Gene

genes like me logo Genes that share pathways with CCNB2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001701 in utero embryonic development IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with CCNB2: view

No data available for SIGNOR curated interactions for CCNB2 Gene

Drugs & Compounds for CCNB2 Gene

(3) Drugs for CCNB2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
serine Nutra 420
tyrosine Nutra 547
genes like me logo Genes that share compounds with CCNB2: view

Transcripts for CCNB2 Gene

Unigene Clusters for CCNB2 Gene

Cyclin B2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2:
SP3:

Relevant External Links for CCNB2 Gene

GeneLoc Exon Structure for
CCNB2
ECgene alternative splicing isoforms for
CCNB2

Expression for CCNB2 Gene

mRNA expression in normal human tissues for CCNB2 Gene

mRNA differential expression in normal tissues according to GTEx for CCNB2 Gene

This gene is overexpressed in Testis (x12.5).

Protein differential expression in normal tissues from HIPED for CCNB2 Gene

This gene is overexpressed in Testis (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNB2 Gene



SOURCE GeneReport for Unigene cluster for CCNB2 Gene Hs.194698

genes like me logo Genes that share expression patterns with CCNB2: view

Protein tissue co-expression partners for CCNB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CCNB2 Gene

Orthologs for CCNB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNB2 36
  • 99 (a)
OneToOne
CCNB2 35
  • 99.58 (n)
  • 99.25 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNB2 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnb2 36
  • 89 (a)
OneToOne
Ccnb2 16
Ccnb2 35
  • 86.62 (n)
  • 89.9 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNB2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
CCNB2 35
  • 90.85 (n)
  • 93.2 (a)
cow
(Bos Taurus)
Mammalia CCNB2 36
  • 93 (a)
OneToOne
CCNB2 35
  • 87.86 (n)
  • 92.96 (a)
rat
(Rattus norvegicus)
Mammalia Ccnb2 35
  • 87.57 (n)
  • 90.43 (a)
chicken
(Gallus gallus)
Aves CCNB2 36
  • 69 (a)
OneToOne
CCNB2 35
  • 69.71 (n)
  • 70.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397743 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnb2 35
  • 63.73 (n)
  • 61.92 (a)
Ccnb2 35
zebrafish
(Danio rerio)
Actinopterygii ccnb2 36
  • 54 (a)
OneToOne
ccnb2 35
  • 62.28 (n)
  • 60.78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4250 35
fruit fly
(Drosophila melanogaster)
Insecta CycB 36
  • 28 (a)
OneToMany
CycB 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea cyb-2.2 36
  • 29 (a)
ManyToMany
cyb-2.1 36
  • 30 (a)
ManyToMany
cyb-1 36
  • 30 (a)
ManyToMany
cyb-2.2 37
  • 34 (a)
cyb-2.1 37
  • 34 (a)
cyb-1 37
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB2 36
  • 27 (a)
ManyToMany
CLB3 36
  • 27 (a)
ManyToMany
CLB4 36
  • 22 (a)
ManyToMany
CLB5 36
  • 22 (a)
ManyToMany
CLB6 36
  • 23 (a)
ManyToMany
CLB2 38
CLB1 36
  • 27 (a)
ManyToMany
CLB2 35
  • 54.32 (n)
  • 47.41 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15543g 35
  • 50.38 (n)
  • 44.7 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR099W 35
  • 48.39 (n)
  • 40.96 (a)
soybean
(Glycine max)
eudicotyledons Gma.174 35
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCB2;4 35
  • 52.17 (n)
  • 41.5 (a)
rice
(Oryza sativa)
Liliopsida Os04g0563700 35
  • 49.41 (n)
  • 43.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3299 36
  • 39 (a)
OneToMany
Species with no ortholog for CCNB2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNB2 Gene

ENSEMBL:
Gene Tree for CCNB2 (if available)
TreeFam:
Gene Tree for CCNB2 (if available)

Paralogs for CCNB2 Gene

Paralogs for CCNB2 Gene

(5) SIMAP similar genes for CCNB2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CCNB2 Gene

genes like me logo Genes that share paralogs with CCNB2: view

Variants for CCNB2 Gene

Sequence variations from dbSNP and Humsavar for CCNB2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs10185 -- 59,124,916(-) AAAAA(A/G)GGCAC utr-variant-3-prime
rs750975 -- 59,123,731(+) TATTA(A/G)TAACA intron-variant
rs755786 -- 59,118,456(-) atctg(C/T)ccacc intron-variant
rs879545 -- 59,124,466(-) TTTAC(A/G)ACACC intron-variant
rs1486878 -- 59,123,268(-) CCATA(C/G)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNB2 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
nsv527307 CNV Gain 19592680
nsv833025 CNV Gain 17160897

Variation tolerance for CCNB2 Gene

Residual Variation Intolerance Score: 65.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNB2 Gene

HapMap Linkage Disequilibrium report
CCNB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNB2 Gene

Disorders for CCNB2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCNB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
anauxetic dysplasia
  • spondylometaepiphyseal dysplasia anauxetic type
breast cancer
  • breast cancer, invasive ductal
- elite association
Search CCNB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNB2

Genetic Association Database (GAD)
CCNB2
Human Genome Epidemiology (HuGE) Navigator
CCNB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNB2
genes like me logo Genes that share disorders with CCNB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNB2 Gene

Publications for CCNB2 Gene

  1. Enforcing temporal control of maternal mRNA translation during oocyte cell-cycle progression. (PMID: 19959990) Arumugam K. … MacNicol A.M. (EMBO J. 2010) 23 67
  2. The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription. (PMID: 20015071) MA1ller G.A. … Engeland K. (FEBS J. 2010) 23 67
  3. Regulation of cyclin B2 expression and cell cycle G2/m transition by menin. (PMID: 20404349) Wu T. … Hua X. (J. Biol. Chem. 2010) 23 67
  4. [Molecular mechanism of radiosensitizing effect of paclitaxel]. (PMID: 19664331) Weng W.W. … Hong C.J. (Ai Zheng 2009) 23 67
  5. Grade-dependent effects on cell cycle progression and apoptosis in response to doxorubicin in human bladder cancer cell lines. (PMID: 19082486) Stravopodis D.J. … Voutsinas G.E. (Int. J. Oncol. 2009) 23 67

Products for CCNB2 Gene

Sources for CCNB2 Gene

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