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CCNB2 Gene

protein-coding   GIFtS: 71
GCID: GC15P059397

Cyclin B2

  See CCNB2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin B21 2
HsT172992
G2/Mitotic-Specific Cyclin-B22

External Ids:    HGNC: 15801   Entrez Gene: 91332   Ensembl: ENSG000001574567   OMIM: 6027555   UniProtKB: O950673   

Export aliases for CCNB2 gene to outside databases

Previous GC identifers: GC15P054954 GC15P052444 GC15P056976 GC15P057113 GC15P057184 GC15P036219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNB2 Gene:
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2,
associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in
their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily
associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin
B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CCNB2 Gene:
CCNB2 (cyclin B2) is a protein-coding gene. Diseases associated with CCNB2 include cartilage-hair hypoplasia. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNB2_HUMAN, O95067
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition

Gene Wiki entry for CCNB2 (Cyclin B2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNB2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   IRF-1   GATA-2   Nkx3-1 v2   POU2F1   POU2F1a   Sox9   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNB2 promoter sequence
   Search Chromatin IP Primers for CCNB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q21.3

CCNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNB2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P059397:  view genomic region     (about GC identifiers)

Start:
59,397,277 bp from pter      End:
59,417,244 bp from pter
Size:
19,968 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCNB2_HUMAN, O95067 (See protein sequence)
Recommended Name: G2/mitotic-specific cyclin-B2  
Size: 398 amino acids; 45282 Da
Subunit: Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as
maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex
Developmental stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis
Secondary accessions: B3KM93 Q6FI99

Explore the universe of human proteins at neXtProt for CCNB2: NX_O95067

Explore proteomics data for CCNB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys328, Lys360, Lys367
  • Modification sites at PhosphoSitePlus

  • See CCNB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004692.1  
    ENSEMBL proteins: 
     ENSP00000288207   ENSP00000453685  
    Reactome Protein details: O95067

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    antibodies-online proteins for CCNB2 (8 products) 

     
    antibodies-online peptides for CCNB2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry O95067

    ProtoNet protein and cluster: O95067

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNB2_HUMAN, O95067
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily


    Find genes that share domains with CCNB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNB2_HUMAN, O95067
    Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15232106
    GO:0019901protein kinase binding IEA--
         
    Find genes that share ontologies with CCNB2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCNB2:
     Increased cell death in breast 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccnb2):
     growth/size/body  hematopoietic system  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with CCNB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccnb2tm1Thnt for CCNB2

       genOway: Develop your customized and physiologically relevant rodent model for CCNB2

    miRNA
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    miRTarBase miRNAs that target CCNB2:
    hsa-let-7a-5p (MIRT052637), hsa-let-7b-5p (MIRT051889), hsa-let-7c-5p (MIRT051866), hsa-let-7f-5p (MIRT051400), hsa-mir-23b-3p (MIRT046347)

    Block miRNA regulation of human, mouse, rat CCNB2 using miScript Target Protectors
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    Addgene plasmids for CCNB2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus3
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with CCNB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNB2 About   (see all 29)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    3Regulation of PLK1 Activity at G2/M Transition
    Regulation of PLK1 Activity at G2/M Transition0.77
    Mitotic G2-G2/M phases0.69
    G2/M Transition0.70
    Polo-like kinase mediated events0.00
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Condensation of Prometaphase Chromosomes0.00
    Resolution of Sister Chromatid Cohesion0.92
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with CCNB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNB2 (see all 10)
        14-3-3 and Cell Cycle Regulation
    Calpain Protease Regulates Cellular Mechanics
    DNA Damage Induced 14-3-3Sigma Signaling
    Breast Cancer Regulation by Stathmin1
    ATM Pathway

    4 GeneGo (Thomson Reuters) Pathways for CCNB2
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Chromosome condensation in prometaphase
    Cell cycle Spindle assembly and chromosome separation
    Cell cycle Cell cycle (generic schema)

    5 BioSystems Pathways for CCNB2
        DNA damage response
    Cell cycle
    TGF-beta Receptor Signaling Pathway
    RB in Cancer
    FOXM1 transcription factor network


    Selected Reactome Pathways for CCNB2 (see all 10)
        Resolution of Sister Chromatid Cohesion
    G2/M DNA replication checkpoint
    Regulation of PLK1 Activity at G2/M Transition
    Golgi Cisternae Pericentriolar Stack Reorganization
    Nuclear Pore Complex (NPC) Disassembly


    Selected Kegg Pathways  (Kegg details for CCNB2) (see all 6):
        FoxO signaling pathway
    Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    Progesterone-mediated oocyte maturation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNB2: 
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNB2 (O950671, 2, 3 ENSP000002882074) via UniProtKB, MINT, STRING, and/or I2D (see all 319)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNAP213331, 2, 3, ENSP000003588664EBI-375024,EBI-350432 MINT-4653303 MINT-4653263 MINT-4653380 MINT-4653285 MINT-4653339 MINT-4653322 MINT-4653401 MINT-4653361 I2D: score=1 STRING: ENSP00000358866
    CDK2P249411, 2, 3, ENSP000002669704EBI-375024,EBI-375096 MINT-50430 I2D: score=5 STRING: ENSP00000266970
    CDKN1AP389362, 3, ENSP000002447414MINT-50432 I2D: score=5 STRING: ENSP00000244741
    MCM2P497362, 3, ENSP000002650564MINT-50431 I2D: score=5 STRING: ENSP00000265056
    MUS81Q96NY93, ENSP000003078534I2D: score=6 STRING: ENSP00000307853
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001701in utero embryonic development IEA--
    GO:0007049cell cycle ----

    Find genes that share ontologies with CCNB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNB2

    3 Novoseek inferred chemical compound relationships for CCNB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 30.1 2 1374905 (1), 16408274 (1)
    serine 8.73 1 1532584 (1)
    tyrosine 4.97 2 7543054 (2)



    Find genes that share compounds with CCNB2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNB2 gene: 
    NM_004701.3  

    Unigene Cluster for CCNB2:

    Cyclin B2
    Hs.194698  [show with all ESTs]
    Unigene Representative Sequence: AM851054
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288207(uc002afz.3) ENST00000561077 ENST00000559622 ENST00000559301

    miRNA
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    Additional mRNA sequence: 

    AB020981.1 AF002822.1 AF087910.1 AK001404.1 AK022385.1 AK023404.1 AK222611.1 AL080146.1 
    AM851054.1 BC105086.1 BC105112.1 BT019458.1 CR533527.1 

    10 DOTS entries:

    DT.454235  DT.99943957  DT.87015542  DT.40214404  DT.121063773  DT.95174036  DT.121045250  DT.121063767 
    DT.92462756  DT.121063779 

    Selected AceView cDNA sequences (see all 309):

    AU143015 BI260155 BX358206 BI858560 BX102366 AL080146 BU165059 BU173062 
    NM_004701 AF002822 BU742917 BU162221 AB020981 BU176998 CR606395 BG681291 
    BE502584 BP351245 AK001404 BG761581 BQ439750 CA430482 CR607796 BX402439 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCNB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for CCNB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACCTCTTC
    CCNB2 Expression
    About this image


    CCNB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             XX Germ Cells Ovigerous Cord
    CCNB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194698
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNB2: 
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNB2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnb21 , 5 cyclin B21, 5 86.62(n)1
    89.9(a)1
      9 (39.53 cM)5
    124421  NM_007630.21  NP_031656.21 
     704076895 
    chicken
    (Gallus gallus)
    Aves CCNB21 cyclin B2 69.71(n)
    70.56(a)
      415400  NM_001004369.1  NP_001004369.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977432 C-B2 mRNA 75.61(n)    J03167.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnb21 cyclin B2 62.28(n)
    60.78(a)
      368316  NM_199430.1  NP_955462.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycB3 cytokinesis cyclin-dependent protein
    kinase, regulator
    42(a)   59B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea cyb-2.23 cyclin 34(a)
    (best of 3)
      I(4114879-4116074)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLB2(YPR119W)4
    CLB21
    B-type cyclin involved in cell cycle progression; activates more4
    CLB21
    54.32(n)1
    47.41(a)1
      16(771653-773128)4
    8562361, 4  NP_015444.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYCB2;41 CYCB2;4 52.17(n)
    41.5(a)
      843964  NM_106281.5  NP_177758.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g05637001 Os04g0563700 49.41(n)
    43.08(a)
      4336670  NM_001060099.1  NP_001053564.1 


    ENSEMBL Gene Tree for CCNB2 (if available)
    TreeFam Gene Tree for CCNB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNB2 gene
    CCNE12  CCND32  CCNO2  CCNE22  CCNB32  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  
    5 SIMAP similar genes for CCNB2 using alignment to 2 protein entries:     CCNB2_HUMAN (see all proteins):
    CCNB2V    CCNB1    CCNB1V    CCNA2    CCNB3

    Find genes that share paralogs with CCNB2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCNB2
    PGOHUM00000232589


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNB2 (see all 612)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894634841,2
    --59395339(+) TCAGTA/TGCTTT 1 -- us2k10--------
    rs1808137781,2
    --59395446(+) TAATAC/TGTAGG 1 -- us2k10--------
    rs1415385841,2
    C--59395514(+) ATCAC-/TGTGTTT 1 -- us2k10--------
    rs80260391,2
    C,F--59395705(+) attttC/Gtgtac 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1462166871,2
    --59395710(+) CTGTAC/TCCACT 1 -- us2k10--------
    rs1852589301,2
    --59395717(+) CACTCA/GGTCGA 1 -- us2k10--------
    rs1390762411,2
    --59395909(+) CATTCC/GTACCA 1 -- us2k10--------
    rs1899259441,2
    --59395924(+) TGTTTA/GAGCAT 1 -- us2k10--------
    rs1812404471,2
    --59395980(+) TTTTTA/GAGGTT 1 -- us2k10--------
    rs1458012321,2
    C--59395983(+) TTGAG-/GTTT  
            
    TTTTT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNB2 (59397277 - 59417244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCNB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527307CNV Gain19592680
    nsv904254CNV Gain21882294
    nsv833025CNV Gain17160897
    nsv7266OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNB2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602755    OMIM disorders: --

    1 disease for CCNB2:    
    About MalaCards
    cartilage-hair hypoplasia

    1 disease from the University of Copenhagen DISEASES database for CCNB2:
    cartilage-hair hypoplasia

    Find genes that share disorders with CCNB2           About GenesLikeMe

    3 Novoseek inferred disease relationships for CCNB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 4.01 3 17289878 (2), 15331390 (1)
    adenocarcinoma 0 8 17289878 (6)
    colorectal cancer 0 2 17289878 (2)

    Genetic Association Database (GAD): CCNB2
    Human Genome Epidemiology (HuGE) Navigator: CCNB2 (1 document)

    Export disorders for CCNB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNB2 gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with CCNB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    5. NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma. (PubMed id 17289878)1, 9 Park S.H....Kim D.G. (Clin. Cancer Res. 2007)
    6. Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2. (PubMed id 17533373)1, 9 Bellanger S....Sobczak-ThAcpot J. (Oncogene 2007)
    7. Functional association of TGF-beta receptor II with cyclin B. (PubMed id 9926943)1, 9 Liu J.H....Djeu J.Y. (Oncogene 1999)
    8. Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function. (PubMed id 12482752)1, 9 Salsi V....Mantovani R. (J. Biol. Chem. 2003)
    9. Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus. (PubMed id 7737117)1, 9 Jackman M....Pines J. (EMBO J. 1995)
    10. HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. (PubMed id 19223528)1, 9 De Martino I....Fusco A. (Cancer Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9133 HGNC: 1580 AceView: CCNB2 Ensembl:ENSG00000157456 euGenes: HUgn9133
    ECgene: CCNB2 Kegg: 9133 H-InvDB: CCNB2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNB2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnb2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNB2 gene:
    Search GeneIP for patents involving CCNB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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