External Ids for CCNB2 Gene
Previous GeneCards Identifiers for CCNB2 Gene
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNB2 Gene
CCNB2 (Cyclin B2) is a Protein Coding gene. Diseases associated with CCNB2 include anauxetic dysplasia and breast cancer. Among its related pathways are Regulation of Glucokinase by Glucokinase Regulatory Protein and Mitotic Prophase. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCND2.
UniProtKB/Swiss-Prot for CCNB2 Gene
Essential for the control of the cell cycle at the G2/M (mitosis) transition.