External Ids for CCNB2 Gene
Previous GeneCards Identifiers for CCNB2 Gene
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNB2 Gene
CCNB2 (Cyclin B2) is a Protein Coding gene. Diseases associated with CCNB2 include Anauxetic Dysplasia and Breast Cancer. Among its related pathways are DNA Damage Induced 14-3-3Sigma Signaling and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNB1.
UniProtKB/Swiss-Prot for CCNB2 Gene
Essential for the control of the cell cycle at the G2/M (mitosis) transition.