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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNB2 Gene

protein-coding   GIFtS: 67
GCID: GC15P059397

cyclin B2
 Explore 18 diseases affiliated with
CCNB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCNB2    

Aliases
for CCNB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin B21 2
HsT172991 2
G2/Mitotic-Specific Cyclin-B22

External Ids:    HGNC: 15801   Entrez Gene: 91332   Ensembl: ENSG000001574567   OMIM: 6027555   UniProtKB: O950673   

Export aliases for CCNB2 gene to outside databases

Previous GC identifers: GC15P054954 GC15P052444 GC15P056976 GC15P057113 GC15P057184 GC15P036219


Summaries
for CCNB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CCNB2:
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate
with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their
subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the
Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role
in transforming growth factor beta-mediated cell cycle control. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCNB2_HUMAN, O95067
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition

Gene Wiki entry for CCNB2 (Cyclin B2)


Genomic Views
for CCNB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNB2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   IRF-1   GATA-2   Nkx3-1 v2   POU2F1   POU2F1a   Sox9   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q21.3

CCNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNB2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P059397:  view genomic region     (about GC identifiers)

Start:
 59,397,277 bp from pter      End:
 59,417,244 bp from pter
Size:
 19,968 bases      Orientation:
 plus strand

Proteins
for CCNB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CCNB2_HUMAN, O95067 (See protein sequence)
Recommended Name: G2/mitotic-specific cyclin-B2  
Size: 398 amino acids; 45282 Da
Subunit: Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as
maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex
Developmental stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis
Secondary accessions: B3KM93 Q6FI99

Explore the universe of human proteins at neXtProt for CCNB2: NX_O95067

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95067

    • CCNB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004692.1  
    ENSEMBL proteins: 
     ENSP00000288207   ENSP00000453685  
    Reactome Protein details: O95067
    Human Recombinant Protein Products: 
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    Novus Biologicals CCNB2 Lysate
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    ProSpec Recombinant Protein for CCNB2
    Uscn Proteins for CCNB2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005634nucleus IEA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0015630microtubule cytoskeleton IDA--


    CCNB2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CCNB2

    Protein Domains /
    Families
    for CCNB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CCNB2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry O95067

    ProtoNet protein and cluster: O95067

    1 Blocks protein family: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNB2_HUMAN, O95067
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily


    Function
    for CCNB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CCNB2_HUMAN, O95067
    Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: CCNB2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNB2 (see all 7)
    OriGene shRNA RFP: CCNB2
    OriGene siRNA: CCNB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNB2

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNB2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CCNB2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IEA--


    CCNB2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CCNB2:
     Increased cell death in breast 

    Animal Models:
         Mouse knock-out Ccnb2tm1Thnt for CCNB2
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ccnb2):
     cellular  growth/size  hematopoietic system  immune system  mortality/aging 
     reproductive system 

    CCNB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CCNB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clearance of Nuclear Envelope Membranes from Chromatin
    		Nuclear Envelope Breakdown0.56
    		Golgi Cisternae Pericentriolar Stack Reorganization0.00
    		Mitotic Prophase0.26
    		Activation of NIMA Kinases NEK9, NEK6, NEK70.00
    2Cell cycle Chromosome condensation in prometaphase
    		Cell cycle_Chromosome condensation in prometaphase1.00
    		Condensation of Prometaphase Chromosomes0.22
    		Cell cycle Chromosome condensation in prometaphase1.00
    3Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    4Cell cycle_Cell cycle (generic schema)
    		Cell cycle_Cell cycle (generic schema)1.00
    		Cell cycle Cell cycle (generic schema)1.00
    5M Phase
    		M Phase1.00
    		Mitotic M-M/G1 phases0.88

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for CCNB2
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Spindle assembly and chromosome separation
    Cell cycle Chromosome condensation in prometaphase
    Cell cycle Cell cycle (generic schema)

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNB2 (see all 10)
        14-3-3 and Cell Cycle Regulation
    Calpain Protease Regulates Cellular Mechanics
    DNA Damage Induced 14-3-3Sigma Signaling
    Breast Cancer Regulation by Stathmin1
    ATM Pathway

    4 GeneGo (Thomson Reuters) Pathways for CCNB2
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Chromosome condensation in prometaphase
    Cell cycle Spindle assembly and chromosome separation
    Cell cycle Cell cycle (generic schema)

    4 BioSystems Pathways for CCNB2 
        DNA damage response
    Cell cycle
    TGF-beta Receptor Signaling Pathway
    FOXM1 transcription factor network

    5/18        Reactome Pathways for CCNB2 (see all 18)
        Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Cell Cycle
    M Phase
    Golgi Cisternae Pericentriolar Stack Reorganization


    4         Kegg Pathways  (Kegg details for CCNB2):
        Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    Progesterone-mediated oocyte maturation


    CCNB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/135 Interacting proteins for CCNB2 (O950672, 3 ENSP000002882074) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNAP213332, 3, ENSP000003588664MINT-4653303 MINT-4653263 MINT-4653380 MINT-4653285 MINT-4653339 MINT-4653322 MINT-4653401 MINT-4653361 I2D: score=1 STRING: ENSP00000358866
    CDKN1AP389362, 3, ENSP000002447414MINT-50432 I2D: score=5 STRING: ENSP00000244741
    MCM2P497362, 3, ENSP000002650564MINT-50431 I2D: score=5 STRING: ENSP00000265056
    CDK2P249412, 3, ENSP000002669704MINT-50430 I2D: score=5 STRING: ENSP00000266970
    TGFBR2P371733, ENSP000003519054I2D: score=3 STRING: ENSP00000351905
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000079regulation of cyclin-dependent protein kinase activity IEA--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001701in utero embryonic development IEA--


    CCNB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CCNB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCNB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNB2
    3 Novoseek chemical compound relationships for CCNB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 30.1 2 1374905 (1), 16408274 (1)
    serine 8.73 1 1532584 (1)
    tyrosine 4.97 2 7543054 (2)

    Search CenterWatch for drugs/clinical trials and news about CCNB2 

    Transcripts
    for CCNB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCNB2 gene: 
    NM_004701.3  

    Unigene Cluster for CCNB2:

    Cyclin B2
    Hs.194698  [show with all ESTs]
    Unigene Representative Sequence: AM851054
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288207(uc002afz.3) ENST00000561077 ENST00000559622 ENST00000559301


    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene shRNA RFP: CCNB2
    OriGene siRNA: CCNB2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB020981.1 AF002822.1 AF087910.1 AK001404.1 AK022385.1 AK023404.1 AK222611.1 AL080146.1 
    AM851054.1 BC105086.1 BC105112.1 BT019458.1 CR533527.1 

    10 DOTS entries:

    DT.454235  DT.99943957  DT.87015542  DT.40214404  DT.121063773  DT.95174036  DT.121045250  DT.121063767 
    DT.92462756  DT.121063779 

    24/309 AceView cDNA sequences (see all 309):

    BM788644 BU162221 BP369266 BP352367 BQ427936 BU543077 BI858560 BQ439750 
    BI260155 CR533527 CA423609 AK001404 BE122764 BE047883 CB129822 CA422966 
    BG761581 AI696374 AB020981 CR600767 BM747499 AL080146 BX374537 BM852959 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCNB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for CCNB2

    Expression
    for CCNB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAACCTCTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCNB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Adult human kidney epithelial cells (Primary Cell)Kidney

    See CCNB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNB2

    SOURCE GeneReport for Unigene cluster: Hs.194698
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCNB2: 
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CCNB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNB2 gene from 7/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CCNB21 cyclin B2 69.71(n)
    70.56(a)    		   415400  NM_001004369.1  NP_001004369.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3977432 C-B2 mRNA 75.61(n)    J03167.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ccnb21 cyclin B2 62.27(n)
    60.96(a)    		   368316  NM_199430.1  NP_955462.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CycB3 cytokinesis cyclin-dependent protein kinase,
    regulator    		 42(a)   59B2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea cyb-2.23 cyclin 34(a)
    (best of 3)    		   I(4114879-4116074)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CYCB2;21 cyclin-B2-2 50.37(n)
    41.91(a)    		   829714  NM_119727.3  NP_195287.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 cyclin, putative, expressed
    (see all 5)    		 29(a)
    28(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 4(28033577-28036540)
    6(30914031-30917864)


    ENSEMBL Gene Tree for CCNB2 (if available)
    TreeFam Gene Tree for CCNB2 (if available) 

    Paralogs
    for CCNB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNB2 gene
    CCND32  CCNO2  CCNE12  CCNE22  CCNB32  CCNB12  CCND12  CCNA12  
    CCND22  CCNA22  
    5 SIMAP similar genes for CCNB2 using alignment to 2 protein entries:     CCNB2_HUMAN (see all proteins):
    CCNB2V    CCNB1    CCNB1V    CCNA2    CCNB3

    CCNB2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCNB2
    PGOHUM00000232589


    Genomic Variants
    for CCNB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/510 NCBI SNPs in CCNB2 are shown (see all 510)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1894634841,2
    		--59395339(+) TCAGTA/TGCTTT 1 -- us2k10--------
    rs1808137781,2
    		--59395446(+) TAATAC/TGTAGG 1 -- us2k10--------
    rs1415385841,2
    		C,--59395514(+) ATCAC-/TGTGTTT 1 -- us2k10--------
    rs80260391,2
    		C,F,--59395705(+) attttC/Gtgtac 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1462166871,2
    		--59395710(+) CTGTAC/TCCACT 1 -- us2k10--------
    rs1852589301,2
    		--59395717(+) CACTCA/GGTCGA 1 -- us2k10--------
    rs1390762411,2
    		--59395909(+) CATTCC/GTACCA 1 -- us2k10--------
    rs1899259441,2
    		--59395924(+) TGTTTA/GAGCAT 1 -- us2k10--------
    rs1812404471,2
    		--59395980(+) TTTTTA/GAGGTT 1 -- us2k10--------
    rs1458012321,2
    		C,--59395983(+) TTGAG-/GTTT  
                TTTTT     		1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNB2 (59397277 - 59417244 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCNB2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNB2
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    Disorders / Diseases
    for CCNB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCNB2 for disorders           About GeneDecksing

    OMIM gene information: 602755    OMIM disorders: --

    18 diseases for CCNB2:    About MalaCards
    cartilage-hair hypoplasia    pituitary adenoma    gallbladder carcinoma    ovarian cancer
    azoospermia    lung adenocarcinoma    adenoma    adenocarcinoma
    gastric cancer    infertility    pancreatic cancer    breast cancer
    pancreatitis    retinitis    immunodeficiency    carcinoma
    neuronitis    lung neoplasm

    2 diseases from the University of Copenhagen DISEASES database for CCNB2:
    Anauxetic dysplasia     cartilage-hair hypoplasia

    3 Novoseek disease relationships for CCNB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 4.01 3 17289878 (2), 15331390 (1)
    adenocarcinoma 0 8 17289878 (6)
    colorectal cancer 0 2 17289878 (2)

    Human Genome Epidemiology (HuGE) Navigator: CCNB2 (1 document)

    Export disorders for CCNB2 gene to outside databases

    Publications
    for CCNB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNB2 gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with CCNB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma. (PubMed id 17289878)1, 9 Park S.H....Kim D.G. (2007)
    5. Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2. (PubMed id 17533373)1, 9 Bellanger S....Sobczak-Thepot J. (2007)
    6. Functional association of TGF-beta receptor II with cyclin B. (PubMed id 9926943)1, 9 Liu J.H....Djeu J.Y. (1999)
    7. Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function. (PubMed id 12482752)1, 9 Salsi V....Mantovani R. (2003)
    8. Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus. (PubMed id 7737117)1, 9 Jackman M....Pines J. (1995)
    9. HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. (PubMed id 19223528)1, 9 De Martino I....Fusco A. (2009)
    10. [Molecular mechanism of radiosensitizing effect of pa clitaxel.] (PubMed id 19664331)1, 9 Weng W.W....Hong C.J. (2009)

    External Searches for CCNB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCNB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9133 HGNC: 1580 AceView: CCNB2 Ensembl:ENSG00000157456 euGenes: HUgn9133
    ECgene: CCNB2 Kegg: 9133 H-InvDB: CCNB2

    Other Databases showing CCNB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCNB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNB2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnb2/

    Intellectual Property
    for CCNB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCNB2 gene:
    Search GeneIP for patents involving CCNB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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