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Aliases for CCNB1IP1 Gene

Aliases for CCNB1IP1 Gene

  • Cyclin B1 Interacting Protein 1, E3 Ubiquitin Protein Ligase 2 3
  • Human Enhancer Of Invasion 10 2 3 4
  • C14orf18 3 4
  • HEI10 3 4
  • Chromosome 14 Open Reading Frame 18 2
  • Cyclin B1 Interacting Protein 1 2
  • Cyclin-B1-Interacting Protein 1 4
  • EC 6.3.2.- 4

External Ids for CCNB1IP1 Gene

Previous HGNC Symbols for CCNB1IP1 Gene

  • C14orf18

Previous GeneCards Identifiers for CCNB1IP1 Gene

  • GC14M018770
  • GC14M018771
  • GC14M019849
  • GC14M020779
  • GC14M000901

Summaries for CCNB1IP1 Gene

Entrez Gene Summary for CCNB1IP1 Gene

  • HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]

GeneCards Summary for CCNB1IP1 Gene

CCNB1IP1 (Cyclin B1 Interacting Protein 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot for CCNB1IP1 Gene

  • Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

  • E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis

Gene Wiki entry for CCNB1IP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNB1IP1 Gene

Genomics for CCNB1IP1 Gene

Regulatory Elements for CCNB1IP1 Gene

Genomic Location for CCNB1IP1 Gene

Chromosome:
14
Start:
20,311,368 bp from pter
End:
20,333,312 bp from pter
Size:
21,945 bases
Orientation:
Minus strand

Genomic View for CCNB1IP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNB1IP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB1IP1 Gene

Proteins for CCNB1IP1 Gene

  • Protein details for CCNB1IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPC3-CIP1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase CCNB1IP1
    Protein Accession:
    Q9NPC3

    Protein attributes for CCNB1IP1 Gene

    Size:
    277 amino acids
    Molecular mass:
    31544 Da
    Quaternary structure:
    • Interacts with CCNB1, UBE2L3 and NF2.

neXtProt entry for CCNB1IP1 Gene

Proteomics data for CCNB1IP1 Gene at MOPED

Post-translational modifications for CCNB1IP1 Gene

Antibody Products

No data available for DME Specific Peptides for CCNB1IP1 Gene

Domains & Families for CCNB1IP1 Gene

Protein Domains for CCNB1IP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNB1IP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPC3

UniProtKB/Swiss-Prot:

CIP1_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with CCNB1IP1: view

No data available for Gene Families for CCNB1IP1 Gene

Function for CCNB1IP1 Gene

Molecular function for CCNB1IP1 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis

Enzyme Numbers (IUBMB) for CCNB1IP1 Gene

Gene Ontology (GO) - Molecular Function for CCNB1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12612082
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with CCNB1IP1: view

Phenotypes for CCNB1IP1 Gene

genes like me logo Genes that share phenotypes with CCNB1IP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNB1IP1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CCNB1IP1 Gene

Localization for CCNB1IP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNB1IP1 Gene

Nucleus. Chromosome. Note=Associates to the synaptonemal complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNB1IP1 Gene COMPARTMENTS Subcellular localization image for CCNB1IP1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CCNB1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome --
GO:0000795 colocalizes_with synaptonemal complex ISS --
genes like me logo Genes that share ontologies with CCNB1IP1: view

Pathways & Interactions for CCNB1IP1 Gene

genes like me logo Genes that share pathways with CCNB1IP1: view

Pathways by source for CCNB1IP1 Gene

1 BioSystems pathway for CCNB1IP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9NPC3-CIP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for CCNB1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001825 blastocyst formation IEA --
GO:0007131 reciprocal meiotic recombination ISS --
GO:0007286 spermatid development IEA --
GO:0016567 protein ubiquitination IEA --
GO:0051026 chiasma assembly ISS --
genes like me logo Genes that share ontologies with CCNB1IP1: view

No data available for SIGNOR curated interactions for CCNB1IP1 Gene

Drugs & Compounds for CCNB1IP1 Gene

(3) Drugs for CCNB1IP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for CCNB1IP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with CCNB1IP1: view

Transcripts for CCNB1IP1 Gene

Unigene Clusters for CCNB1IP1 Gene

Cyclin B1 interacting protein 1, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNB1IP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB1IP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: - -
SP8: - -
SP9: -

Relevant External Links for CCNB1IP1 Gene

GeneLoc Exon Structure for
CCNB1IP1
ECgene alternative splicing isoforms for
CCNB1IP1

Expression for CCNB1IP1 Gene

mRNA expression in normal human tissues for CCNB1IP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCNB1IP1 Gene

This gene is overexpressed in Testis (33.1) and Fetal ovary (33.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCNB1IP1 Gene



SOURCE GeneReport for Unigene cluster for CCNB1IP1 Gene Hs.107003

mRNA Expression by UniProt/SwissProt for CCNB1IP1 Gene

Q9NPC3-CIP1_HUMAN
Tissue specificity: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
genes like me logo Genes that share expression patterns with CCNB1IP1: view

Protein tissue co-expression partners for CCNB1IP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCNB1IP1 Gene

Orthologs for CCNB1IP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCNB1IP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNB1IP1 35
  • 92.78 (n)
  • 95.31 (a)
CCNB1IP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNB1IP1 35
  • 91.7 (n)
  • 95.67 (a)
CCNB1IP1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnb1ip1 35
  • 87.2 (n)
  • 88.77 (a)
Ccnb1ip1 16
Ccnb1ip1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNB1IP1 35
  • 99.52 (n)
  • 99.64 (a)
CCNB1IP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnb1ip1 35
  • 86.96 (n)
  • 89.49 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNB1IP1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNB1IP1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNB1IP1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489156 35
  • 72.25 (n)
  • 80.47 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562825 35
  • 58.26 (n)
  • 56.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4611 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for CCNB1IP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNB1IP1 Gene

ENSEMBL:
Gene Tree for CCNB1IP1 (if available)
TreeFam:
Gene Tree for CCNB1IP1 (if available)

Paralogs for CCNB1IP1 Gene

Pseudogenes.org Pseudogenes for CCNB1IP1 Gene

genes like me logo Genes that share paralogs with CCNB1IP1: view

No data available for Paralogs for CCNB1IP1 Gene

Variants for CCNB1IP1 Gene

Sequence variations from dbSNP and Humsavar for CCNB1IP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1132644 -- 20,316,559(-) TTAGG(A/C)CTCTC utr-variant-5-prime
rs1889361 -- 20,329,677(-) TAAAA(C/T)TAGTA intron-variant
rs1889362 -- 20,329,587(-) TCAAC(A/G)GATGA intron-variant
rs1889363 -- 20,329,423(-) TTAGT(C/T)TAGTA intron-variant
rs2297732 -- 20,313,202(+) ACTAC(A/G)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNB1IP1 Gene

Variant ID Type Subtype PubMed ID
esv2554946 CNV Insertion 19546169
esv268213 CNV Insertion 20981092
esv1436404 CNV Insertion 17803354
esv23438 CNV Gain+Loss 19812545

Variation tolerance for CCNB1IP1 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNB1IP1 Gene

HapMap Linkage Disequilibrium report
CCNB1IP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNB1IP1 Gene

Disorders for CCNB1IP1 Gene

Relevant External Links for CCNB1IP1

Genetic Association Database (GAD)
CCNB1IP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNB1IP1
genes like me logo Genes that share disorders with CCNB1IP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCNB1IP1 Gene

Publications for CCNB1IP1 Gene

  1. A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. (PMID: 12612082) Toby G.G. … Golemis E.A. (Mol. Cell. Biol. 2003) 2 23 67
  2. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. (PMID: 21779533) Strong E.R. … Schimenti J.C. (Genes (Basel) 2010) 2 67
  3. Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. (PMID: 17784788) Ward J.O. … Schimenti J.C. (PLoS Genet. 2007) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for CCNB1IP1 Gene

Sources for CCNB1IP1 Gene

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