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CCNB1IP1 Gene

protein-coding   GIFtS: 57
GCID: GC14M020779

Cyclin B1 Interacting Protein 1, E3 Ubiquitin Protein Ligase

(Previous names: chromosome 14 open reading frame 18, cyclin B1 interacting...)
(Previous symbol: C14orf18)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cyclin B1 Interacting Protein 1, E3 Ubiquitin Protein Ligase1 2     Cyclin B1 Interacting Protein 11
C14orf181 2 3 5     E3 Ubiquitin-Protein Ligase CCNB1IP12
Human Enhancer Of Invasion 101 2 3     EC 6.3.2.-3
HEI102 3 5     Cyclin-B1-Interacting Protein 13
Chromosome 14 Open Reading Frame 181     

External Ids:    HGNC: 194371   Entrez Gene: 578202   Ensembl: ENSG000001008147   OMIM: 6082495   UniProtKB: Q9NPC33   
ORGUL members:         

Export aliases for CCNB1IP1 gene to outside databases

Previous GC identifers: GC14M018770 GC14M018771 GC14M019849 GC14M000901


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNB1IP1 Gene:
HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through
G(2)/M.(supplied by OMIM, Apr 2004)

GeneCards Summary for CCNB1IP1 Gene:
CCNB1IP1 (cyclin B1 interacting protein 1, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ligase activity.

UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3
Function: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during
zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby
establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to
stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to
allow the progression of recombination and the implementation of the final steps of crossing over (By
similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the
G2 phase. Overexpression causes delayed entry into mitosis
Function: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle
progression through the G2 phase. Overexpression causes delayed entry into mitosis

Gene Wiki entry for CCNB1IP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNB1IP1 gene promoter:
         N-Myc   GCNF-1   GCNF   STAT5A   GCNF-2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNB1IP1 promoter sequence
   Search Chromatin IP Primers for CCNB1IP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNB1IP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

CCNB1IP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNB1IP1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M020779:  view genomic region     (about GC identifiers)

Start:
20,779,527 bp from pter      End:
20,801,471 bp from pter
Size:
21,945 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase CCNB1IP1  
Size: 277 amino acids; 31544 Da
Subunit: Interacts with CCNB1, UBE2L3 and NF2

Explore the universe of human proteins at neXtProt for CCNB1IP1: NX_Q9NPC3

Explore proteomics data for CCNB1IP1 at MOPED

Post-translational modifications: 

  • Ubiquitinated; autoubiquitinated1
  • Phosphorylated by CDK1 on serine or threonine residues (in vitro)1
  • Ubiquitination2 at Lys163
  • Modification sites at PhosphoSitePlus

  • See CCNB1IP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_067001.3  NP_878269.1  NP_878272.1  

    ENSEMBL proteins: 
     ENSP00000381226   ENSP00000381235   ENSP00000351810   ENSP00000381229   ENSP00000451122  
     ENSP00000452463   ENSP00000452486   ENSP00000450914   ENSP00000452312   ENSP00000452182  
     ENSP00000337396   ENSP00000409896  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q9NPC3

    ProtoNet protein and cluster: Q9NPC3

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with CCNB1IP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIP1_HUMAN, Q9NPC3
    Function: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during
    zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby
    establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to
    stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to
    allow the progression of recombination and the implementation of the final steps of crossing over (By
    similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the
    G2 phase. Overexpression causes delayed entry into mitosis
    Function: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle
    progression through the G2 phase. Overexpression causes delayed entry into mitosis

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12612082
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    Find genes that share ontologies with CCNB1IP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCNB1IP1:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccnb1ip1):
     endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with CCNB1IP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCNB1IP1
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    miRNA
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    hsa-mir-26b-5p (MIRT029964)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CIP1_HUMAN, Q9NPC3: Nucleus. Chromosome. Note=Associates to the synaptonemal complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000795colocalizes with synaptonemal complex ISS--
    GO:0005634nucleus ----
    GO:0005694chromosome ----

    Find genes that share ontologies with CCNB1IP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNB1IP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    1 BioSystems Pathway for CCNB1IP1
        Integrated Breast Cancer Pathway


    UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including CCNB1IP1: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNB1IP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNB1IP1 (Q9NPC31, 2, 3 ENSP000003373964) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNB1P146351, 3, ENSP000002564424EBI-745269,EBI-495332 I2D: score=2 STRING: ENSP00000256442
    UBE2L3P680363, ENSP000003442594I2D: score=2 STRING: ENSP00000344259
    CCNB1IP1Q9NPC32MINT-66642
    KNCNENSP000003796074STRING: ENSP00000379607
    AKAP9ENSP000003485734STRING: ENSP00000348573
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001825blastocyst formation IEA--
    GO:0006915apoptotic process ----
    GO:0007131reciprocal meiotic recombination ISS--
    GO:0007286spermatid development IEA--
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with CCNB1IP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CCNB1IP1 (CIP1)

    4 HMDB Compounds for CCNB1IP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNB1IP1 gene (4 alternative transcripts): 
    NM_182851.1  NM_021178.4  NM_182849.2  NM_182852.3  

    Unigene Cluster for CCNB1IP1:

    Cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
    Hs.107003  [show with all ESTs]
    Unigene Representative Sequence: NM_182852
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398160(uc001vwx.3) ENST00000398169 ENST00000358932(uc001vwz.3)
    ENST00000398163(uc001vwv.3) ENST00000554184 ENST00000556854(uc010ahh.1)
    ENST00000557665 ENST00000554047 ENST00000556563 ENST00000553291 ENST00000553516
    ENST00000555348 ENST00000557114 ENST00000555963 ENST00000353689(uc001vwy.3)
    ENST00000437553(uc021rnp.1)
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      QuantiTect SYBR Green Assays in human, mouse, rat CCNB1IP1
      QuantiFast Probe-based Assays in human, mouse, rat CCNB1IP1

    Additional mRNA sequence: 

    AF216381.1 AK026233.1 AK225253.1 AK225451.1 AK226037.1 AL161994.1 BC000369.2 BC001218.1 
    BC004435.1 

    17 DOTS entries:

    DT.115981  DT.95211208  DT.100643350  DT.101986400  DT.101986399  DT.100879858  DT.100879857  DT.100879862 
    DT.91764188  DT.100879867  DT.100879871  DT.86841881  DT.95104464  DT.97848327  DT.99946032  DT.100659926 
    DT.100683438 

    Selected AceView cDNA sequences (see all 373):

    AI475743 AW007782 BM984301 BG471764 CR593880 CR611584 BF432367 AW055069 
    BM796644 CA418125 BI334158 BM263179 NM_182849 AI038966 BC001218 AI252779 
    AW247345 BU178878 BM971724 BM857384 BQ576273 CB128698 AI374713 BM784807 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCNB1IP1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
    SP1:              -                                   -                                                         
    SP2:                                                  -                       -     -                           
    SP3:                                                  -                       -                                 
    SP4:                                                                                -                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CCNB1IP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCNB1IP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGCACAGT
    CCNB1IP1 Expression
    About this image


    CCNB1IP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    CCNB1IP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNB1IP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.107003

    UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3
    Tissue specificity: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low
    levels in placenta, brain and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including CCNB1IP1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CCNB1IP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB1IP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCNB1IP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnb1ip11 , 5 cyclin B1 interacting protein 11, 5 87.2(n)1
    88.77(a)1
      14 (26.25 cM)5
    2390831  NM_001111119.11  NP_001104589.11 
     507892495 
    lizard
    (Anolis carolinensis)
    Reptilia CCNB1IP16
    cyclin B1 interacting protein 1, E3 ubiquitin prot...
    76(a)
    1 ↔ 1
    GL343220.1(1038495-1044570)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004891561 E3 ubiquitin-protein ligase CCNB1IP1-like 72.25(n)
    80.47(a)
      100489156  XM_002934321.2  XP_002934367.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5628251 E3 ubiquitin-protein ligase CCNB1IP1-like 58.26(n)
    56.2(a)
      562825  XM_686198.5  XP_691290.3 


    ENSEMBL Gene Tree for CCNB1IP1 (if available)
    TreeFam Gene Tree for CCNB1IP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNB1IP1 gene

    Find genes that share paralogs with CCNB1IP1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CCNB1IP1
    PGOHUM00000244697 PGOHUM00000247547 PGOHUM00000241452


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNB1IP1 (see all 471)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429188421,2
    --20779141(+) CCAACC/TCTGTG 3 -- ds50010--------
    rs1511026451,2
    C--20779172(+) GTCCAC/TTCAGG 3 -- ds50010--------
    rs125882131,2
    C,H--20779176(+) actcaC/Gggtta 3 -- ds50010--------
    rs2010946161,2
    C--20779287(+) GGGAC-/CAAACA 3 -- ds50010--------
    rs124315721,2
    H--20779436(+) aaaaaA/Taataa 3 -- ds50010--------
    rs711085911,2
    C--20779476(+) AAAAA-/A/GGAAAA 3 -- ds50011NA 2
    rs3711921801,2
    C--20779477(+) AAAAA-/GAAAAA 3 -- ds50010--------
    rs1855669311,2
    --20779497(+) AAATGA/TAATCA 3 -- ds50010--------
    rs748300241,2
    C,F--20779540(+) TAGCTA/GAATTA 3 -- ut311Minor allele frequency- G:0.05WA 118
    rs1903524661,2
    --20779603(+) CAGTGA/GCATGA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CCNB1IP1 (20779527 - 20801471 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCNB1IP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2554946CNV Insertion19546169
    esv1436404CNV Insertion17803354
    esv268213CNV Insertion20981092
    esv23438CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608249    OMIM disorders: --


    Find genes that share disorders with CCNB1IP1           About GenesLikeMe

    Genetic Association Database (GAD): CCNB1IP1

    Export disorders for CCNB1IP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNB1IP1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with CCNB1IP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. (PubMed id 12612082)1, 2, 3, 9 Toby G.G.... Golemis E.A. (Mol. Cell. Biol. 2003)
    2. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. (PubMed id 21779533)1, 3 Strong E.R. and Schimenti J.C. (Genes (Basel) 2010)
    3. A functional association between merlin and HEI10, a cell cycle regulator. (PubMed id 16532029)1, 2 GrAPnholm M....CarpAcn O. (Oncogene 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. HEI10 negatively regulates cell invasion by inhibiting cyclin B/Cdk1 and other promotility proteins. (PubMed id 17297447)2 Singh M.K....Golemis E.A. (Oncogene 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57820 HGNC: 19437 AceView: CCNB1IP1 Ensembl:ENSG00000100814 euGenes: HUgn57820
    ECgene: CCNB1IP1 H-InvDB: CCNB1IP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCNB1IP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNB1IP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNB1IP1 gene:
    Search GeneIP for patents involving CCNB1IP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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