Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNB1IP1 Gene

protein-coding   GIFtS: 54
GCID: GC14M020779

Cyclin B1 Interacting Protein 1, E3 Ubiquitin Protein Ligase

(Previous names: chromosome 14 open reading frame 18, cyclin B1 interacting...)
(Previous symbol: C14orf18)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin B1 Interacting Protein 1, E3 Ubiquitin Protein Ligase1 2     Cyclin B1 Interacting Protein 11
C14orf181 2 3 5     E3 Ubiquitin-Protein Ligase CCNB1IP12
Human Enhancer Of Invasion 101 2 3     EC 6.3.2.-3
HEI102 3 5     Cyclin-B1-Interacting Protein 13
Chromosome 14 Open Reading Frame 181     

External Ids:    HGNC: 194371   Entrez Gene: 578202   Ensembl: ENSG000001008147   OMIM: 6082495   UniProtKB: Q9NPC33   

Export aliases for CCNB1IP1 gene to outside databases

Previous GC identifers: GC14M018770 GC14M018771 GC14M019849 GC14M000901


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNB1IP1 Gene:
HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through
G(2)/M.(supplied by OMIM, Apr 2004)

GeneCards Summary for CCNB1IP1 Gene: 
CCNB1IP1 (cyclin B1 interacting protein 1, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with CCNB1IP1 include smooth muscle tumor, and intrahepatic cholangiocarcinoma. GO annotations related to this gene include metal ion binding and ligase activity.

UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3
Function: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle
progression through the G2 phase. Overexpression causes delayed entry into mitosis

Gene Wiki entry for CCNB1IP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNB1IP1 gene promoter:
         N-Myc   GCNF-1   GCNF   STAT5A   GCNF-2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNB1IP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNB1IP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNB1IP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

CCNB1IP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNB1IP1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M020779:  view genomic region     (about GC identifiers)

Start:
20,779,527 bp from pter      End:
20,801,471 bp from pter
Size:
21,945 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase CCNB1IP1  
Size: 277 amino acids; 31544 Da
Subunit: Binds CCNB1 and UBE2L3
Subcellular location: Nucleus. Chromosome. Note=May associate with segregating chromosomes during metaphase and
anaphase

Explore the universe of human proteins at neXtProt for CCNB1IP1: NX_Q9NPC3

Explore proteomics data for CCNB1IP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated; autoubiquitinated
  • UniProtKB: Phosphorylated by CDK1 on serine or threonine residues (in vitro)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPC3

  • CCNB1IP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNB1IP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_067001.3  NP_878269.1  NP_878272.1  

    ENSEMBL proteins: 
     ENSP00000381226   ENSP00000381235   ENSP00000351810   ENSP00000381229   ENSP00000451122  
     ENSP00000452463   ENSP00000452486   ENSP00000450914   ENSP00000452312   ENSP00000452182  
     ENSP00000337396   ENSP00000409896  

    Human Recombinant Protein Products for CCNB1IP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCNB1IP1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCNB1IP1
    GenScript Custom Purified and Recombinant Proteins Services for CCNB1IP1
    Novus Biologicals CCNB1IP1 Proteins
    Novus Biologicals CCNB1IP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCNB1IP1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005694chromosome IEA--

    CCNB1IP1 for ontologies           About GeneDecksing



    CCNB1IP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CCNB1IP1
    OriGene Custom Antibody Services for CCNB1IP1
    GenScript Custom Superior Antibodies Services for CCNB1IP1
    Novus Biologicals CCNB1IP1 Antibodies
    Abcam antibodies for CCNB1IP1
    Cloud-Clone Corp. Antibodies for CCNB1IP1 
    ThermoFisher Antibody for CCNB1IP1
    LSBio Antibodies in human, mouse, rat for CCNB1IP1 

    Assay Products for CCNB1IP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCNB1IP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCNB1IP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCNB1IP1 
    Cloud-Clone Corp. CLIAs for CCNB1IP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9NPC3

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIP1_HUMAN, Q9NPC3
    Function: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle
    progression through the G2 phase. Overexpression causes delayed entry into mitosis

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12612082
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    CCNB1IP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCNB1IP1:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccnb1ip1):
     endocrine/exocrine gland  reproductive system 

    CCNB1IP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNB1IP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNB1IP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNB1IP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNB1IP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNB1IP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCNB1IP1
    SwitchGear 3'UTR luciferase reporter plasmidCCNB1IP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCNB1IP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNB1IP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCNB1IP1
    Sirion Biotech Customized adenovirus for overexpression of CCNB1IP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCNB1IP1 (see all 23)
    OriGene ORF clones in mouse, rat for CCNB1IP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCNB1IP1 (NM_182852)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNB1IP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNB1IP1
    Sirion Biotech Customized lentivirus for stable overexpression of CCNB1IP1 
                         Customized lentivirus expression plasmids for stable overexpression of CCNB1IP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCNB1IP1
    Search LifeMap BioReagents cell lines for CCNB1IP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB1IP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCNB1IP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    1 BioSystems Pathway for CCNB1IP1
        Integrated Breast Cancer Pathway


    UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNB1IP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for CCNB1IP1 (Q9NPC31, 2, 3 ENSP000003373964) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNB1P146351, 3, ENSP000002564424EBI-745269,EBI-495332 I2D: score=2 STRING: ENSP00000256442
    UBE2L3P680363, ENSP000003442594I2D: score=2 STRING: ENSP00000344259
    CCNB1IP1Q9NPC32MINT-66642
    PHF12ENSP000003299334STRING: ENSP00000329933
    POMPENSP000003702224STRING: ENSP00000370222
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001825blastocyst formation IEA--
    GO:0006915apoptotic process IEA--
    GO:0007286spermatid development IEA--
    GO:0016567protein ubiquitination IEA--
    GO:0035265organ growth IEA--

    CCNB1IP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCNB1IP1 (CIP1)

    4 HMDB Compounds for CCNB1IP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about CCNB1IP1 / CIP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNB1IP1 gene (4 alternative transcripts): 
    NM_182851.1  NM_021178.4  NM_182849.2  NM_182852.3  

    Unigene Cluster for CCNB1IP1:

    Cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
    Hs.107003  [show with all ESTs]
    Unigene Representative Sequence: NM_182852
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398160(uc001vwx.3) ENST00000398169 ENST00000358932(uc001vwz.3)
    ENST00000398163(uc001vwv.3) ENST00000554184 ENST00000556854(uc010ahh.1)
    ENST00000557665 ENST00000554047 ENST00000556563 ENST00000553291 ENST00000553516
    ENST00000555348 ENST00000557114 ENST00000555963 ENST00000353689(uc001vwy.3)
    ENST00000437553(uc021rnp.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNB1IP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCNB1IP1
    SwitchGear 3'UTR luciferase reporter plasmidCCNB1IP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCNB1IP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNB1IP1
    Clone
    Products:
         
    OriGene clones in human, mouse for CCNB1IP1 (see all 23)
    OriGene ORF clones in mouse, rat for CCNB1IP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CCNB1IP1 (NM_182852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNB1IP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNB1IP1
    Sirion Biotech Customized lentivirus for stable overexpression of CCNB1IP1 
                         Customized lentivirus expression plasmids for stable overexpression of CCNB1IP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCNB1IP1
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNB1IP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCNB1IP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNB1IP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNB1IP1

    Additional mRNA sequence: 

    AF216381.1 AK026233.1 AK225253.1 AK225451.1 AK226037.1 AL161994.1 BC000369.2 BC001218.1 
    BC004435.1 

    17 DOTS entries:

    DT.115981  DT.95211208  DT.100643350  DT.101986400  DT.101986399  DT.100879858  DT.100879857  DT.100879862 
    DT.91764188  DT.100879867  DT.100879871  DT.86841881  DT.95104464  DT.97848327  DT.99946032  DT.100659926 
    DT.100683438 

    24/373 AceView cDNA sequences (see all 373):

    CR611584 BQ223690 BM741413 F03919 AW024810 CA418497 CR621988 BQ680327 
    BQ642590 BU178878 BM561746 BQ576273 BM263179 AA406358 BX161424 BG471764 
    BC004435 AI252779 AW247345 AA205107 CR612618 BM559285 BM741203 BX247978 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CCNB1IP1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
    SP1:              -                                   -                                                         
    SP2:                                                  -                       -     -                           
    SP3:                                                  -                       -                                 
    SP4:                                                                                -                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CCNB1IP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNB1IP1 expression in normal human tissues (normalized intensities)      CCNB1IP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGCACAGT
    CCNB1IP1 Expression
    About this image


    CCNB1IP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             bone marrow cd34+   
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Neuron (Nervous System)
             nerve   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5

    See CCNB1IP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNB1IP1

    SOURCE GeneReport for Unigene cluster: Hs.107003

    UniProtKB/Swiss-Prot: CIP1_HUMAN, Q9NPC3
    Tissue specificity: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low
    levels in placenta, brain and lung

        SABiosciences Expression via Pathway-Focused PCR Array including CCNB1IP1: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCNB1IP1
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNB1IP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCNB1IP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNB1IP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNB1IP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB1IP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCNB1IP1 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnb1ip11 , 5 cyclin B1 interacting protein 11, 5 87.2(n)1
    88.77(a)1
      14 (26.25 cM)5
    2390831  NM_001111119.11  NP_001104589.11 
     507892495 
    lizard
    (Anolis carolinensis)
    Reptilia CCNB1IP16
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343220.1(1038495-1044570)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5628251 e3 ubiquitin-protein ligase CCNB1IP1-like 58.26(n)
    56.2(a)
      562825  XM_686198.4  XP_691290.3 


    ENSEMBL Gene Tree for CCNB1IP1 (if available)
    TreeFam Gene Tree for CCNB1IP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNB1IP1 gene

    CCNB1IP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CCNB1IP1
    PGOHUM00000244697 PGOHUM00000247547 PGOHUM00000241452


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/471 SNPs in CCNB1IP1 are shown (see all 471)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429188421,2
    --20779141(+) CCAACC/TCTGTG 3 -- ds50010--------
    rs1511026451,2
    C--20779172(+) GTCCAC/TTCAGG 3 -- ds50010--------
    rs125882131,2
    C,H--20779176(+) actcaC/Gggtta 3 -- ds50010--------
    rs2010946161,2
    C--20779287(+) GGGAC-/CAAACA 3 -- ds50010--------
    rs124315721,2
    H--20779436(+) aaaaaA/Taataa 3 -- ds50010--------
    rs711085911,2
    C--20779476(+) AAAAA-/A/GGAAAA 3 -- ds50011NA 2
    rs3711921801,2
    C--20779477(+) AAAAA-/GAAAAA 3 -- ds50010--------
    rs1855669311,2
    --20779497(+) AAATGA/TAATCA 3 -- ds50010--------
    rs748300241,2
    C,F--20779540(+) TAGCTA/GAATTA 3 -- ut311Minor allele frequency- G:0.05WA 118
    rs1903524661,2
    --20779603(+) CAGTGA/GCATGA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CCNB1IP1 (20779527 - 20801471 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CCNB1IP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2554946CNV Insertion19546169
    esv1436404CNV Insertion17803354
    esv268213CNV Insertion20981092
    esv23438CNV Gain+Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNB1IP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNB1IP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608249    OMIM disorders: --

    5 diseases for CCNB1IP1:    About MalaCards
    smooth muscle tumor    intrahepatic cholangiocarcinoma    cholangiocarcinoma    gastric cancer
    breast cancer


    CCNB1IP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCNB1IP1

    Export disorders for CCNB1IP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNB1IP1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with CCNB1IP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. (PubMed id 12612082)1, 2, 3, 9 Toby G.G.... Golemis E.A. (2003)
    2. Evidence Implicating CCNB1IP1, a RING Domain-Containi ng Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. (PubMed id 21779533)1, 3 Strong E.R. and Schimenti J.C. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. A functional association between merlin and HEI10, a cell cycle regulator. (PubMed id 16532029)1 Gronholm M....Carpen O. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57820 HGNC: 19437 AceView: CCNB1IP1 Ensembl:ENSG00000100814 euGenes: HUgn57820
    ECgene: CCNB1IP1 H-InvDB: CCNB1IP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNB1IP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNB1IP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNB1IP1 gene:
    Search GeneIP for patents involving CCNB1IP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CCNB1IP1   OriGene RNAi products in human, mouse, rat for CCNB1IP1  
     OriGene qPCR primer pairs and template standards for CCNB1IP1   OriGene Protein Over-expression Lysate for CCNB1IP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CCNB1IP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCNB1IP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CCNB1IP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCNB1IP1   OriGene Custom Protein Services for CCNB1IP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCNB1IP1
     QIAGEN SeqTarget long-range PCR primers for resequencing CCNB1IP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNB1IP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNB1IP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNB1IP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNB1IP1
     GenScript Custom Purified and Recombinant Proteins Services for CCNB1IP1 GenScript cDNA clones with any tag delivered in your preferred vector for CCNB1IP1
     GenScript Custom Assay Services for CCNB1IP1 GenScript Custom Superior Antibodies Services for CCNB1IP1
     GenScript Custom overexpressing Cell Line Services for CCNB1IP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CCNB1IP1 promoter
     Search Chromatin IP Primers for CCNB1IP1
     RT2 qPCR Primer Assay in human, mouse, rat CCNB1IP1
     GNC Network for CCNB1IP1
     SABiosciences PCR Arrays including human, mouse, rat CCNB1IP1
     Search Tocris compounds for CCNB1IP1 (CIP1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCNB1IP1 antibodies
     CCNB1IP1 proteins
     CCNB1IP1 lysates
     Antibodies for CCNB1IP1
     See all of Abcam's Antibodies, Kits and Proteins for CCNB1IP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CCNB1IP1
     Antibodies for CCNB1IP1
     ELISAs for CCNB1IP1
     CLIAs for CCNB1IP1
     Search LifeMap BioReagents cell lines for CCNB1IP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB1IP1
     SwitchGear 3'UTR luciferase reporter plasmids for CCNB1IP1
     SwitchGear Promoter luciferase reporter plasmids for CCNB1IP1
     ThermoFisher Antibody for CCNB1IP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNB1IP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNB1IP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNB1IP1
    Customized:
     lentivirus for stable overexpression of CCNB1IP1
     lentivirus expression plasmids for stable overexpression of CCNB1IP1
     adenovirus for overexpression of CCNB1IP1
     LSBio Antibodies in human, mouse, rat for CCNB1IP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCNB1IP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4