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Aliases for CCNB1 Gene

Aliases for CCNB1 Gene

  • Cyclin B1 2 3
  • G2/Mitotic-Specific Cyclin B1 2 3
  • CCNB 3 4
  • G2/Mitotic-Specific Cyclin-B1 3

External Ids for CCNB1 Gene

Previous HGNC Symbols for CCNB1 Gene

  • CCNB

Previous GeneCards Identifiers for CCNB1 Gene

  • GC05P068614
  • GC05P070028
  • GC05P068433
  • GC05P068478
  • GC05P068498
  • GC05P068462
  • GC05P065418

Summaries for CCNB1 Gene

Entrez Gene Summary for CCNB1 Gene

  • The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNB1 Gene

CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include adrenal carcinoma and tetraploidy. Among its related pathways are GPCR Pathway and GPCR Pathway. GO annotations related to this gene include protein kinase binding and patched binding. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNB1 Gene

  • Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Gene Wiki entry for CCNB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNB1 Gene

Genomics for CCNB1 Gene

Regulatory Elements for CCNB1 Gene

Genomic Location for CCNB1 Gene

Start:
69,167,010 bp from pter
End:
69,178,245 bp from pter
Size:
11,236 bases
Orientation:
Plus strand

Genomic View for CCNB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB1 Gene

Proteins for CCNB1 Gene

  • Protein details for CCNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14635-CCNB1_HUMAN
    Recommended name:
    G2/mitotic-specific cyclin-B1
    Protein Accession:
    P14635
    Secondary Accessions:
    • A8K066
    • Q5TZP9

    Protein attributes for CCNB1 Gene

    Size:
    433 amino acids
    Molecular mass:
    48337 Da
    Quaternary structure:
    • Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization.

    Three dimensional structures from OCA and Proteopedia for CCNB1 Gene

    Alternative splice isoforms for CCNB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNB1 Gene

Proteomics data for CCNB1 Gene at MOPED

Post-translational modifications for CCNB1 Gene

  • Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.
  • Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
  • Ubiquitination at Lys190
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNB1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCNB1 (CCNB1)

No data available for DME Specific Peptides for CCNB1 Gene

Domains for CCNB1 Gene

Protein Domains for CCNB1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14635

UniProtKB/Swiss-Prot:

CCNB1_HUMAN :
  • P14635
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNB1: view

No data available for Gene Families for CCNB1 Gene

Function for CCNB1 Gene

Molecular function for CCNB1 Gene

GENATLAS Biochemistry: cyclin B1,complexing with CDC2 (M phase promoting factor (MPF) component),regulating G2/M transition (checkpoint) of the cell cycle,nucleocytoplasmic shuttling protein,accumulating in the cytoplasm through S and G2 phases and translocating to the nucleus during prophase
UniProtKB/Swiss-Prot Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Gene Ontology (GO) - Molecular Function for CCNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005113 patched binding IPI 11331587
GO:0005515 protein binding IPI 10373560
GO:0016301 kinase activity --
GO:0019901 protein kinase binding IPI 12524548
GO:0035173 histone kinase activity IEA --
genes like me logo Genes that share ontologies with CCNB1: view

Phenotypes for CCNB1 Gene

MGI mutant phenotypes for CCNB1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CCNB1:
genes like me logo Genes that share phenotypes with CCNB1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCNB1 Gene

Localization for CCNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNB1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNB1 Gene COMPARTMENTS Subcellular localization image for CCNB1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 3
extracellular 1

Gene Ontology (GO) - Cellular Components for CCNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 18195732
GO:0000942 condensed nuclear chromosome outer kinetochore IDA 18195732
GO:0005634 nucleus IDA 11331587
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CCNB1: view

Pathways for CCNB1 Gene

genes like me logo Genes that share pathways with CCNB1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cell Cycle in human,mouse,rat
    • Cellular Senescence in human,mouse,rat
    • Cytoskeleton Regulators in human,mouse,rat
    • MAP Kinase (MAPK) Signaling Pathway in human,mouse,rat
    • p53 Signaling Pathway in human,mouse,rat

Gene Ontology (GO) - Biological Process for CCNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001556 oocyte maturation IEA --
genes like me logo Genes that share ontologies with CCNB1: view

Compounds for CCNB1 Gene

(85) Novoseek inferred chemical compound relationships for CCNB1 Gene

Compound -log(P) Hits PubMed IDs
purvalanol a 64.8 1
nocodazole 61.7 6
methylprotodioscin 58 1
aloeemodin 55.9 2
paclitaxel 54.8 31
genes like me logo Genes that share compounds with CCNB1: view

Transcripts for CCNB1 Gene

Unigene Clusters for CCNB1 Gene

Cyclin B1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4:
SP5:

Relevant External Links for CCNB1 Gene

GeneLoc Exon Structure for
CCNB1
ECgene alternative splicing isoforms for
CCNB1

Expression for CCNB1 Gene

mRNA expression in normal human tissues for CCNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNB1 Gene

This gene is overexpressed in Esophagus - Mucosa (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNB1 Gene

SOURCE GeneReport for Unigene cluster for CCNB1 Gene Hs.23960

genes like me logo Genes that share expressions with CCNB1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CCNB1 Gene

Orthologs for CCNB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNB1 35
  • 99.92 (n)
  • 99.77 (a)
CCNB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNB1 35
  • 89.77 (n)
  • 90.16 (a)
CCNB1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
CCNB1 35
  • 90.9 (n)
  • 91.76 (a)
mouse
(Mus musculus)
Mammalia Ccnb1 35
  • 82.05 (n)
  • 84.15 (a)
Ccnb1 16
Ccnb1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNB1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNB1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnb1 35
  • 83.1 (n)
  • 84.36 (a)
lizard
(Anolis carolinensis)
Reptilia CCNB1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ccnb1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnb1.2 35
  • 69.88 (n)
  • 70.56 (a)
MGC76039 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7163 35
zebrafish
(Danio rerio)
Actinopterygii ccnb1 35
  • 65.82 (n)
  • 66.67 (a)
ccnb1 36
  • 65 (a)
OneToMany
ccnb1l 36
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004962 35
  • 52.13 (n)
  • 48.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycB 35
  • 51.92 (n)
  • 46.4 (a)
CycB 36
  • 30 (a)
OneToMany
CycB 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea cyb-1 36
  • 34 (a)
ManyToMany
cyb-2.1 36
  • 31 (a)
ManyToMany
cyb-2.2 36
  • 29 (a)
ManyToMany
cyb-1 37
  • 37 (a)
cyb-2.2 37
  • 34 (a)
cyb-2.1 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB1 36
  • 26 (a)
ManyToMany
CLB2 36
  • 26 (a)
ManyToMany
CLB3 35
  • 45.62 (n)
  • 35.84 (a)
CLB3 36
  • 26 (a)
ManyToMany
CLB4 36
  • 26 (a)
ManyToMany
CLB5 36
  • 24 (a)
ManyToMany
CLB5 38
CLB6 36
  • 24 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCB1;3 35
  • 48.75 (n)
  • 39.5 (a)
rice
(Oryza sativa)
Liliopsida Os.9246 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3299 36
  • 39 (a)
OneToMany
Species with no ortholog for CCNB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNB1 Gene

ENSEMBL:
Gene Tree for CCNB1 (if available)
TreeFam:
Gene Tree for CCNB1 (if available)

Paralogs for CCNB1 Gene

Paralogs for CCNB1 Gene

Selected SIMAP similar genes for CCNB1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CCNB1: view

Variants for CCNB1 Gene

Sequence variations from dbSNP and Humsavar for CCNB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs163442 -- 69,167,779(+) CCCAT(A/G)TTTTC intron-variant
rs163443 -- 69,168,407(+) GATAC(A/G)TGCAA intron-variant
rs163444 -- 69,168,717(+) TTGTT(A/G)TCCAA intron-variant
rs164387 -- 69,165,269(+) ccgta(A/G)aagac upstream-variant-2KB
rs164388 -- 69,170,742(+) tgcct(G/T)ggcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNB1 Gene

Variant ID Type Subtype PubMed ID
nsv509066 CNV Insertion 20534489
esv2671857 CNV Deletion 23128226

Relevant External Links for CCNB1 Gene

HapMap Linkage Disequilibrium report
CCNB1
Human Gene Mutation Database (HGMD)
CCNB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNB1 Gene

Disorders for CCNB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for CCNB1 Gene including...

Search for CCNB1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CCNB1 Gene

(67) Novoseek inferred disease relationships for CCNB1 Gene

Disease -log(P) Hits PubMed IDs
cancer 62.4 47
tumors 58.6 100
colon cancer 50.7 6
breast cancer 50.5 34
retinoblastoma 50.4 6

Relevant External Links for CCNB1

Genetic Association Database (GAD)
CCNB1
Human Genome Epidemiology (HuGE) Navigator
CCNB1
Tumor Gene Database (TGDB):
CCNB1
genes like me logo Genes that share disorders with CCNB1: view

No data available for UniProtKB/Swiss-Prot for CCNB1 Gene

Publications for CCNB1 Gene

  1. Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. (PMID: 12447691) Yuan J. … Strebhardt K. (Oncogene 2002) 3 4 23
  2. NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. (PMID: 16009132) Bassermann F. … Duyster J. (Cell 2005) 3 4 23
  3. The crystal structure of human cyclin B. (PMID: 17495533) Petri E.T. … Basavappa R. (Cell Cycle 2007) 3 4 23
  4. Cyclin B1 is useful to predict occult cervical lymph node metastases in tongue carcinoma. (PMID: 17167975) Harada H. … Mogi S. (J. Exp. Clin. Cancer Res. 2006) 3 23
  5. Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor. (PMID: 17359284) Suzuki T. … Sasano H. (Cancer Sci. 2007) 3 23

Products for CCNB1 Gene

  • Addgene plasmids for CCNB1

Sources for CCNB1 Gene

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