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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCNB1 Gene

protein-coding GIFtS: 71
GCID: GC05P068462

cyclin B1

(Previous symbol: CCNB)

Explore 96 diseases affiliated with
CCNB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin B1¹ ²
CCNB¹ ² ³
G2/Mitotic-Specific Cyclin B1²
G2/Mitotic-Specific Cyclin-B1²

External Ids:	HGNC: 1579¹	Entrez Gene: 891²	Ensembl: ENSG00000134057⁷	OMIM: 123836⁵	UniProtKB: P14635³

Export aliases for CCNB1 gene to outside databases

Previous GC identifers: GC05P068614 GC05P070028 GC05P068433 GC05P068478 GC05P068498 GC05P065418

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNB1:

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2)

to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed

transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different

transcripts result from the use of alternate transcription initiation sites. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCNB1_HUMAN, P14635

Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition

Gene Wiki entry for CCNB1 (Cyclin B1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNB1 gene promoter:
LHX3b/Lhx3b p53 p300 NF-AT YY1 NF-AT4 NF-AT2 NF-AT3 LHX3a/Lhx3a NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNB1 promoter sequence

Search SABiosciences Chromatin IP Primers for CCNB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q12

CCNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNB1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P068462: view genomic region (about GC identifiers)

Start:	68,462,837 bp from pter	End:	68,474,072 bp from pter
Size:	11,236 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCNB1_HUMAN, P14635 (See protein sequence)

Recommended Name: G2/mitotic-specific cyclin-B1

Size: 433 amino acids; 48337 Da

Subunit: Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as

maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10.

Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase.

Interacts with CCNF; interaction is required for nuclear localization

Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome

Developmental stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis

2 PDB 3D structures from and Proteopedia for CCNB1:

2B9R (3D)

2JGZ (3D)

Explore the universe of human proteins at neXtProt for CCNB1: NX_P14635

Post-translational modifications:

Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M

phases¹

Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear

import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary

phosphorylation site¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P14635

CCNB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_114172.1

ENSEMBL proteins:

ENSP00000256442 ENSP00000423387 ENSP00000426092 ENSP00000424588 ENSP00000425103

ENSP00000426230

Reactome Protein details: P14635
Human Recombinant Protein Products:

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	Novus Biologicals CCNB1 Proteins Novus Biologicals CCNB1 Lysates
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	ProSpec Recombinant Protein for CCNB1
	Uscn Proteins for CCNB1

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	18195732
GO:0000942	condensed nuclear chromosome outer kinetochore	IDA	18195732
GO:0005624	membrane fraction	--	--
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IDA	11331587

CCNB1 for ontologies About GeneDecksing

CCNB1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNB1
	R&D Systems Antibodies for CCNB1 (Cyclin B1)
	Cell Signaling Technology (CST) Antibodies for CCNB1
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	Abcam antibodies for CCNB1
	Uscn Antibodies for CCNB1
	ThermoFisher Antibody for CCNB1

Assay Products for CCNB1:

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	GenScript Custom Assay Services for CCNB1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCNB1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCNB1 for domains About GeneDecksing

4 InterPro domains/families:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR004367 Cyclin_C

IPR014400 Cyclin_A/B/D/E

Graphical View of Domain Structure for InterPro Entry P14635

ProtoNet protein and cluster: P14635

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNB1_HUMAN, P14635

Similarity: Belongs to the cyclin family. Cyclin AB subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCNB1_HUMAN, P14635

Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition

Genatlas biochemistry entry for CCNB1:

cyclin B1,complexing with CDC2 (M phase promoting factor (MPF) component),regulating G2/M transition (checkpoint) of

the cell cycle,nucleocytoplasmic shuttling protein,accumulating in the cytoplasm through S and G2 phases and

translocating to the nucleus during prophase

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNB1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNB1 (see all 18):
		hsa-miR-548j hsa-miR-607 hsa-miR-548i hsa-let-7a-2* hsa-let-7g* hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-192*

		SwitchGear 3'UTR luciferase reporter plasmid: CCNB1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005113	patched binding	IPI	11331587
GO:0005515	protein binding	IPI	--
GO:0016301	kinase activity	IEA	--
GO:0019901	protein kinase binding	IPI	12524548
GO:0035173	histone kinase activity	--	--

CCNB1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CCNB1:

Upregulation of Wnt/beta-caten

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ccnb1):

mortality/aging

CCNB1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/42 super-pathways (see all 42) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

APC/C:Cdc20 mediated degradation of mitotic proteins	0.69	Regulation of mitotic cell cycle	0.58
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.68	APC/C-mediated degradation of cell cycle proteins	0.58
Regulation of APC/C activators between G1/S and early anaphase	0.62	Cell Cycle Checkpoints	0.42

G2/M DNA damage checkpoint

	G2/M DNA damage checkpoint	1.00			G2/M DNA replication checkpoint	0.30
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	0.56			Activation of Cyclin B/Cdk1 by Cdc25a (string) protein	0.20

Recruitment of mitotic centrosome proteins and complexes

	Recruitment of mitotic centrosome proteins and complexes	1.00			G2/M Transition	0.83
	Centrosome maturation	1.00			Mitotic G2-G2/M phases	0.81

Clearance of Nuclear Envelope Membranes from Chromatin

	Nuclear Envelope Breakdown	0.56			Golgi Cisternae Pericentriolar Stack Reorganization	0.00
	Mitotic Prophase	0.26			Activation of NIMA Kinases NEK9, NEK6, NEK7	0.00

Cell cycle Chromosome condensation in prometaphase

	Cell cycle_Chromosome condensation in prometaphase	1.00			Condensation of Prometaphase Chromosomes	0.22
	Cell cycle Chromosome condensation in prometaphase	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for CCNB1

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Spindle assembly and chromosome separation
	Meiosis
	Cell cycle Chromosome condensation in prometaphase
	Cell cycle Cell cycle (generic schema)

5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNB1 (see all 10)

	14-3-3 and Cell Cycle Regulation
	Calpain Protease Regulates Cellular Mechanics
	DNA Damage Induced 14-3-3Sigma Signaling
	Breast Cancer Regulation by Stathmin1
	ATM Pathway

1 Cell Signaling Technology (CST) Pathway for CCNB1

Cell Cycle / Checkpoint Control

4 GeneGo (Thomson Reuters) Pathways for CCNB1

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Chromosome condensation in prometaphase
	Cell cycle Spindle assembly and chromosome separation
	Cell cycle Cell cycle (generic schema)

5/11 BioSystems Pathways for CCNB1 (see all 11)

	Cell cycle
	DNA damage response
	AMPK signaling
	G1 to S cell cycle control
	Hedgehog Signaling Pathway

5/37 Reactome Pathways for CCNB1 (see all 37)

	Mitotic Prometaphase
	APC/C:Cdc20 mediated degradation of mitotic proteins
	Recruitment of mitotic centrosome proteins and complexes
	Phosphorylation of the APC/C
	Recruitment of NuMA to mitotic centrosomes

4 Kegg Pathways (Kegg details for CCNB1):

	Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	Progesterone-mediated oocyte maturation

CCNB1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/882 Interacting proteins for CCNB1 (P14635^{1, 2, 3} ENSP00000256442⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 882)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK1	P06493¹^,²^,³	EBI-495332,EBI-444308 MINT-7945693 MINT-6549429 I2D: score=13
PLK1	P53350²^,³, ENSP00000300093⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000300093
ANAPC1	Q9H1A4²^,³, ENSP00000339109⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000339109
CDC16	Q13042²^,³, ENSP00000348554⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000348554
CDC23	Q9UJX2²^,³, ENSP00000378350⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000378350

About this table

Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000079	regulation of cyclin-dependent protein kinase activity	IEA	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000236	mitotic prometaphase	IDA	18195732

CCNB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCNB1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCNB1
10/85 Novoseek chemical compound relationships for CCNB1 gene (see all 85) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
purvalanol a	64.8	1	17474786 (1)
nocodazole	61.7	6	10194549 (2), 15302583 (1), 10623472 (1), 10896848 (1) (see all 5)
methylprotodioscin	58	1	16458429 (1)
aloeemodin	55.9	3	19942342 (1), 15207375 (1)
paclitaxel	54.8	35	19609944 (5), 9506539 (4), 9710718 (2), 16849574 (2) (see all 19)
2-methoxyestradiol	53.1	1	17234781 (1)
mimosine	51.6	1	16085357 (1)
n-ipa	49.9	2	16009132 (1), 17389604 (1)
olomoucine	48.2	1	15536083 (1)
adpribose	45.9	4	17064874 (1), 18563491 (1), 19942342 (1), 16733797 (1)

Search CenterWatch for drugs/clinical trials and news about CCNB1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCNB1 gene:

NM_031966.3

Unigene Cluster for CCNB1:

Cyclin B1

Hs.23960 [show with all ESTs]

Unigene Representative Sequence: NM_031966

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000256442(uc003jvm.3 uc010ixb.3) ENST00000506572 ENST00000508407

ENST00000505500 ENST00000503507 ENST00000507798 ENST00000513102

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		hsa-miR-548j hsa-miR-607 hsa-miR-548i hsa-let-7a-2* hsa-let-7g* hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-192*

		SwitchGear 3'UTR luciferase reporter plasmid: CCNB1 3' UTR sequence

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNB1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNB1

Additional cDNA sequence:

AK289431.1 AM851053.1 AY027761.1 AY027762.1 AY027763.1 AY027764.1 AY027765.1 AY027766.1

AY027767.1 AY027768.1 AY027769.1 AY027770.1 BC006510.2 BT020128.1 M25753.1

17 DOTS entries:

DT.95191897 DT.316650 DT.100031451 DT.100878043 DT.120801085 DT.95179466 DT.100878050 DT.120801063

DT.92459404 DT.95191894 DT.95191913 DT.100701644 DT.100878037 DT.100878045 DT.102828589 DT.92459403

DT.92459409

24/718 AceView cDNA sequences (see all 718):

AY027768 BE910087 BU171520 NM_031966 BM973693 CB137571 BQ653201 BE252087

BM904112 AL711040 BU528317 BQ676384 CA423213 AA807009 BQ772784 BU854802

BU607365 CB109662 BQ069763 BU161904 BU157465 BU957542 BU557348 CB158886

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNB1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9a	·	9b
SP1:					-														-
SP2:																			-								-
SP3:					-												-		-
SP4:
SP5:

ECgene alternative splicing isoforms for CCNB1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCNB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCATCTGT

About this image

CCNB1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Epicardium

Kidney Endothelial Cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCNB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNB1

SOURCE GeneReport for Unigene cluster: Hs.23960

SABiosciences Expression via Pathway-Focused PCR Arrays including CCNB1:

Cytoskeleton Regulators in human mouse rat

Cell Cycle in human mouse rat

p53 Signaling Pathway in human mouse rat

Cellular Senescence in human mouse rat

MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNB1 gene from 9/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccnb1⁵	cyclin B1	--		13 (53.23 cM) 100778650
lizard (Anolis carolinensis)	Reptilia	CCNB1⁶	--	68(a)	1 ↔ 1	2(12368557-12377325)
African clawed frog (Xenopus laevis)	Amphibia	ccnb1-prov²	cyclin B1	76.65(n)		BC041302.1
zebrafish (Danio rerio)	Actinopterygii	ccnb1²	cyclin B1	73.7(n)		58025 AB040435.1
fruit fly (Drosophila melanogaster)	Insecta	CycB^{1 , 3}	cytokinesis cyclin-dependent protein kinase, regulator³ Cyclin B¹	44(a)³ 46.52(n)¹ 37.86(a)¹		59B2³ 37618¹ NM_166557.2¹ NP_726246.1¹
worm (Caenorhabditis elegans)	Secernentea	cyb-1³	cyclin	37(a) (best of 3)		IV(10735631-10736927) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CLB5(YPR120C)⁴ CLB2¹	B-type cyclin involved in DNA replication during S more⁴ Clb2p¹	50.07(n)¹ 42.29(a)¹		16(775182-773875)⁴ 856236¹ NP_015444.1¹ 856237⁴ NP_015445.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	CYC1BAT¹	cyclin-B1-2	45.85(n) 34.52(a)		830502 NM_120697.2 NP_196233.1
rice (Oryza sativa)	Liliopsida	Os.9246²	O.sativa mRNA for cyclin 1	71.25(n)		X82035.1

ENSEMBL Gene Tree for CCNB1 (if available)
TreeFam Gene Tree for CCNB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCNB1 gene

CCND3² CCNO² CCNE1² CCNB2² CCNE2² CCNB3² CCND1² CCNA1²

CCND2² CCNA2²

8 SIMAP similar genes for CCNB1 using alignment to 6 protein entries: CCNB1_HUMAN (see all proteins):

CCNB1V CCNE2 CCNE1 CCNB2 CCNB2V CNTD2

CCNA2 CCNB3

CCNB1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189175638^1,2		--	68460948(+)	`ATGAAA/GAAAAC`	1	--	us2k¹		0	--	--	--	--
rs6867050^1,2	C,F,A,	--	68461039(+)	`gcactT/Ctggga`	1	--	us2k¹		5		WA NA	244
rs164387^1,2	C,F,	--	68461096(+)	`CCGTAA/GAAGAC`	1	--	us2k¹		12		NA WA CSA EA	374
rs143194594^1,2		--	68461119(+)	`GTGAAC/TCTTAA`	1	--	us2k¹		0	--	--	--	--
rs151215123^1,2		--	68461168(+)	`GTAGGC/TTAACA`	1	--	us2k¹		0	--	--	--	--
rs140952718^1,2		--	68461237(+)	`ATGCTC/GTATAC`	1	--	us2k¹		0	--	--	--	--
rs78191173^1,2	C,	--	68461295(+)	`GCATAT/CAAAAG`	1	--	us2k¹		2		WA	120
rs192463799^1,2		--	68461409(+)	`ACATGC/GTGAAA`	1	--	us2k¹		0	--	--	--	--
rs113808103^1,2		--	68461447(+)	`TTAGCT/CGGCCG`	1	--	us2k¹		1		CSA	1
rs184826394^1,2		--	68461569(+)	`CTGGGC/TGACAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCNB1 (68462837 - 68474072 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNB1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNB1

DNA2.0 Custom Variant and Variant Library Synthesis for CCNB1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCNB1 for disorders           About GeneDecksing

OMIM gene information: 123836    OMIM disorders: --

20/96 diseases for CCNB1 (see all 96):    About MalaCards

diffuse large b-cell lymphoma dna topoisomerase ii adenomatous polyposis coli b-cell lymphomas

laryngeal squamous cell carcinoma squamous cell carcinoma testicular germ cell tumor non-hodgkin lymphoma

germ cell tumor anaplastic astrocytoma neuroendocrine tumor barrett's esophagus

carcinoma adenoid cystic carcinoma mantle cell lymphoma pulmonary neuroendocrine tumor

squamous cell carcinoma of the head and neck esophageal squamous cell carcinoma malt lymphoma tetraploidy

1 disease from the University of Copenhagen DISEASES database for CCNB1:

Cancer

10/67 Novoseek disease relationships for CCNB1 gene (see all 67) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	62.4	57	12883711 (3), 19666607 (3), 19223507 (3), 9030252 (3) (see all 33)
tumors	58.6	138	12438226 (5), 19681484 (4), 19666607 (4), 10945597 (4) (see all 60)
colon cancer	50.7	7	18671143 (1), 18097607 (1), 14613989 (1), 17390015 (1) (see all 6)
breast cancer	50.5	35	19470724 (5), 19609944 (3), 20103625 (3), 9164677 (2) (see all 22)
retinoblastoma	50.4	6	10485490 (2), 14674679 (1), 7666202 (1), 17148439 (1) (see all 5)
carcinoma squamous cell	44.4	19	10071250 (2), 11895914 (2), 15320491 (2), 18048386 (2) (see all 14)
promyelocytic leukemia	41.8	1	16619512 (1)
cervical carcinoma	41.4	2	10741643 (1), 16614707 (1)
breast carcinoma	39.6	7	17359284 (4), 9664138 (1), 12888910 (1)
prostate cancer	39.3	9	17513602 (3), 14613989 (2), 10854060 (1), 16762917 (1) (see all 6)

Human Genome Epidemiology (HuGE) Navigator: CCNB1 (4 documents)
Tumor Gene Database (TGDB): CCNB1

Export disorders for CCNB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCNB1 gene, integrated from 9 sources (see all 951):
(articles sorted by number of sources associating them with CCNB1)

Utopia: connect your pdf to the dynamic
world of online information

Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. (PubMed id 12447691)^{1, 2, 9} Yuan J....Strebhardt K. (2002)
Active cyclin B1-Cdk1 first appears on centrosomes in prophase. (PubMed id 12524548)^{1, 2, 9} Jackman M....Pines J. (2003)
The crystal structure of human cyclin B. (PubMed id 17495533)^{1, 2, 9} Petri E.T.... Basavappa R. (2007)
NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. (PubMed id 16009132)^{1, 2, 9} Bassermann F.... Duyster J. (2005)
Cyclin B and cyclin A confer different substrate recognition properties on CDK2. (PubMed id 17495531)^{1, 2} Brown N.R....Johnson L.N. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. (PubMed id 15181148)^{1, 2} Baus Charrier-Savournin F.... Dulic V. (2004)
A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. (PubMed id 12612082)^{1, 2} Toby G.G.... Golemis E.A. (2003)
RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. (PubMed id 12775724)^{1, 2} Rosse C.... Camonis J. (2003)
Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. (PubMed id 10716937)^{1, 2} Kong M....Donoghue D.J. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 891	HGNC: 1579	AceView: CCNB1	Ensembl:ENSG00000134057	euGenes: HUgn891
ECgene: CCNB1	Kegg: 891	H-InvDB: CCNB1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCNB1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCNB1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccnb1/

Intellectual Property for CCNB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CCNB1 gene:
Search GeneIP for patents involving CCNB1

GeneCards and IP:
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cyclin B1

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CCNB1 Gene

cyclin B1

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