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CCNB1 Gene

protein-coding   GIFtS: 72
GCID: GC05P068462

Cyclin B1


(Previous symbol: CCNB)
  See CCNB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin B11 2
CCNB1 2 3
G2/Mitotic-Specific Cyclin B11 2
G2/Mitotic-Specific Cyclin-B12

External Ids:    HGNC: 15791   Entrez Gene: 8912   Ensembl: ENSG000001340577   OMIM: 1238365   UniProtKB: P146353   

Export aliases for CCNB1 gene to outside databases

Previous GC identifers: GC05P068614 GC05P070028 GC05P068433 GC05P068478 GC05P068498 GC05P065418


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNB1 Gene:
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with
p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a
constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during
G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CCNB1 Gene:
CCNB1 (cyclin B1) is a protein-coding gene. Diseases associated with CCNB1 include adrenal carcinoma, and tetraploidy. GO annotations related to this gene include patched binding and protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNB1_HUMAN, P14635
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition

Gene Wiki entry for CCNB1 (Cyclin B1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNB1 gene promoter:
         LHX3b/Lhx3b   p53   p300   NF-AT   YY1   NF-AT4   NF-AT2   NF-AT3   LHX3a/Lhx3a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCNB1 promoter sequence
   Search Chromatin IP Primers for CCNB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q12

CCNB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNB1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P068462:  view genomic region     (about GC identifiers)

Start:
68,462,837 bp from pter      End:
68,474,072 bp from pter
Size:
11,236 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCNB1_HUMAN, P14635 (See protein sequence)
Recommended Name: G2/mitotic-specific cyclin-B1  
Size: 433 amino acids; 48337 Da
Subunit: Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as
maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10.
Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during
interphase. Interacts with CCNF; interaction is required for nuclear localization
Developmental stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis
2 PDB 3D structures from and Proteopedia for CCNB1:
2B9R (3D)        2JGZ (3D)    
Secondary accessions: A8K066 Q5TZP9
Alternative splicing: 2 isoforms:  P14635-1   P14635-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCNB1: NX_P14635

Explore proteomics data for CCNB1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during
    G2/M phases1
  • Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear
    import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary
    phosphorylation site1
  • Ubiquitination2 at Lys190
  • Modification sites at PhosphoSitePlus

  • See CCNB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114172.1  
    ENSEMBL proteins: 
     ENSP00000256442   ENSP00000423387   ENSP00000426092   ENSP00000424588   ENSP00000425103  
     ENSP00000426230  
    Reactome Protein details: P14635

    CCNB1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCNB1
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    Novus Biologicals CCNB1 Proteins
    Novus Biologicals CCNB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCNB1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCNB1 

     
    antibodies-online proteins for CCNB1 (11 products) 

     
    antibodies-online peptides for CCNB1

    CCNB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNB1
    R&D Systems Antibodies for CCNB1 (Cyclin B1)
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    Novus Biologicals CCNB1 Antibodies
    Abcam antibodies for CCNB1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CCNB1
    antibodies-online antibodies for CCNB1 (280 products) 

    CCNB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCNB1 
    antibodies-online kits for CCNB1 (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P14635

    ProtoNet protein and cluster: P14635

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNB1_HUMAN, P14635
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily


    Find genes that share domains with CCNB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNB1_HUMAN, P14635
    Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition

         Genatlas biochemistry entry for CCNB1:
    cyclin B1,complexing with CDC2 (M phase promoting factor (MPF) component),regulating G2/M transition (checkpoint)
    of the cell cycle,nucleocytoplasmic shuttling protein,accumulating in the cytoplasm through S and G2 phases and
    translocating to the nucleus during prophase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005113patched binding IPI11331587
    GO:0005515protein binding IPI10373560
    GO:0016301kinase activity IEA--
    GO:0019901protein kinase binding IPI12524548
         
    Find genes that share ontologies with CCNB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCNB1:
     Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ccnb1):
     mortality/aging 

    Find genes that share phenotypes with CCNB1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCNB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCNB1:
    hsa-mir-92a-3p (MIRT049477), hsa-mir-20a-5p (MIRT050578), hsa-mir-24-3p (MIRT030588), hsa-mir-132-3p (MIRT021866), hsa-let-7b-5p (MIRT051879), hsa-mir-212-3p (MIRT024969), hsa-mir-183-5p (MIRT047127)

    Block miRNA regulation of human, mouse, rat CCNB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNB1 (see all 18):
    hsa-miR-548j hsa-miR-607 hsa-miR-548i hsa-let-7a-2* hsa-let-7g* hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidCCNB1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNB1

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    GenScript: all cDNA clones in your preferred vector: CCNB1 (NM_031966)
    Sino Biological Human cDNA Clone for CCNB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNB1
    Addgene plasmids for CCNB1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNB1

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10369) for CCNB1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNB1_HUMAN, P14635: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    mitochondrion3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA18195732
    GO:0000942condensed nuclear chromosome outer kinetochore IDA18195732
    GO:0005634nucleus IDA11331587
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with CCNB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNB1 About   (see all 38)  
    See pathways by source

    SuperPathContained pathways About
    1E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    E2F-enabled inhibition of pre-replication complex formation0.00
    G1 to S cell cycle control0.35
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    4PLK1 signaling events
    PLK1 signaling events
    Phosphorylation of Emi10.00
    5ATM Pathway
    ATM Pathway
    ATM Signaling Pathway0.00


    Find genes that share SuperPaths with CCNB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNB1 (see all 10)
        14-3-3 and Cell Cycle Regulation
    Calpain Protease Regulates Cellular Mechanics
    DNA Damage Induced 14-3-3Sigma Signaling
    Breast Cancer Regulation by Stathmin1
    ATM Pathway

    1 Cell Signaling Technology (CST) Pathway for CCNB1
        Cell Cycle / Checkpoint Control

    4 GeneGo (Thomson Reuters) Pathways for CCNB1
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Chromosome condensation in prometaphase
    Cell cycle Spindle assembly and chromosome separation
    Cell cycle Cell cycle (generic schema)

    Selected BioSystems Pathways for CCNB1 (see all 13)
        Cell cycle
    DNA damage response
    G1 to S cell cycle control
    Hedgehog Signaling Pathway
    AMPK signaling


    Selected Reactome Pathways for CCNB1 (see all 19)
        Resolution of Sister Chromatid Cohesion
    E2F-enabled inhibition of pre-replication complex formation
    Recruitment of NuMA to mitotic centrosomes
    Phosphorylation of the APC/C
    Golgi Cisternae Pericentriolar Stack Reorganization


    5 Kegg Pathways  (Kegg details for CCNB1):
        FoxO signaling pathway
    Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    Progesterone-mediated oocyte maturation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNB1: 
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNB1 (P146351, 2, 3 ENSP000002564424) via UniProtKB, MINT, STRING, and/or I2D (see all 1121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK1P064931, 2, 3EBI-495332,EBI-444308 MINT-7945693 MINT-6549429 I2D: score=13 
    PLK1P533502, 3, ENSP000003000934MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000300093
    ACTR1AP611632, 3, ENSP000003589214MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000358921
    ANAPC1Q9H1A42, 3, ENSP000003391094MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000339109
    CDC16Q130422, 3, ENSP000003485544MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000348554
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001556oocyte maturation IEA--

    Find genes that share ontologies with CCNB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNB1

    Selected Novoseek inferred chemical compound relationships for CCNB1 gene (see all 85)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    purvalanol a 64.8 1 17474786 (1)
    nocodazole 61.7 6 10194549 (2), 15302583 (1), 10623472 (1), 10896848 (1) (see all 5)
    methylprotodioscin 58 1 16458429 (1)
    aloeemodin 55.9 3 19942342 (1), 15207375 (1)
    paclitaxel 54.8 35 19609944 (5), 9506539 (4), 9710718 (2), 16849574 (2) (see all 19)
    2-methoxyestradiol 53.1 1 17234781 (1)
    mimosine 51.6 1 16085357 (1)
    n-ipa 49.9 2 16009132 (1), 17389604 (1)
    olomoucine 48.2 1 15536083 (1)
    adpribose 45.9 4 17064874 (1), 18563491 (1), 19942342 (1), 16733797 (1)



    Find genes that share compounds with CCNB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNB1 gene: 
    NM_031966.3  

    Unigene Cluster for CCNB1:

    Cyclin B1
    Hs.23960  [show with all ESTs]
    Unigene Representative Sequence: NM_031966
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256442(uc003jvm.3 uc010ixb.3) ENST00000506572 ENST00000508407
    ENST00000505500 ENST00000503507 ENST00000507798 ENST00000513102
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CCNB1 (see all 18):
    hsa-miR-548j hsa-miR-607 hsa-miR-548i hsa-let-7a-2* hsa-let-7g* hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidCCNB1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNB1
    Addgene plasmids for CCNB1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCNB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CCNB1
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      QuantiFast Probe-based Assays in human, mouse, rat CCNB1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10369) for CCNB1 

    Additional mRNA sequence: 

    AK289431.1 AM851053.1 AY027761.1 AY027762.1 AY027763.1 AY027764.1 AY027765.1 AY027766.1 
    AY027767.1 AY027768.1 AY027769.1 AY027770.1 BC006510.2 BT020128.1 M25753.1 

    17 DOTS entries:

    DT.95191897  DT.316650  DT.100031451  DT.100878043  DT.120801085  DT.95179466  DT.100878050  DT.120801063 
    DT.92459404  DT.95191894  DT.95191913  DT.100701644  DT.100878037  DT.100878045  DT.102828589  DT.92459403 
    DT.92459409 

    Selected AceView cDNA sequences (see all 718):

    BX356204 AA807018 BM973693 CR613568 BM801983 BE271905 BM852317 BX384779 
    AL711040 BI334715 BU161904 CR602024 CR602926 BP338081 BE280182 BQ422553 
    BU944528 CR622796 AY027768 BE278166 BQ676384 BP364588 BQ648792 CA427308 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCNB1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
    SP1:              -                                         -                                       
    SP2:                                                        -                       -               
    SP3:              -                                   -     -                                       
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CCNB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCNB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCATCTGT
    CCNB1 Expression
    About this image


    CCNB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
     
     Gonad (Reproductive System)    fully expand to see all 2 entries
             Primordial Germ Cells Primitive Gonad
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
    CCNB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23960
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNB1: 
              Cytoskeleton Regulators in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNB1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccnb11 , 5 cyclin B11, 5 82.05(n)1
    84.15(a)1
      13 (53.23 cM)5
    2686971  NM_172301.31  NP_758505.21 
     1007786505 
    lizard
    (Anolis carolinensis)
    Reptilia CCNB16
    cyclin B1
    71(a)
    1 ↔ 1
    2(12368234-12378524)
    African clawed frog
    (Xenopus laevis)
    Amphibia ccnb1-prov2 cyclin B1 76.65(n)    BC041302.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccnb12 cyclin B1 73.7(n)   58025  AB040435.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycB1 , 3 cytokinesis cyclin-dependent protein
    kinase, regulator3
    Cyclin B1
    44(a)3
    51.92(n)1
    46.4(a)1
      59B23
    376181  NM_166555.21  NP_726244.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cyb-13 cyclin 37(a)
    (best of 3)
      IV(10735631-10736927)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLB5(YPR120C)4
    CLB31
    B-type cyclin involved in DNA replication during S more4
    CLB31
    45.62(n)1
    35.84(a)1
      16(775182-773875)4
    8514001  NP_010126.11  8562374 
     NP_015445.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYCB1;31 CYCB1;3 48.75(n)
    39.5(a)
      820325  NM_111985.4  NP_187759.2 
    rice
    (Oryza sativa)
    Liliopsida Os.92462 O.sativa mRNA for cyclin 1 71.25(n)    X82035.1 


    ENSEMBL Gene Tree for CCNB1 (if available)
    TreeFam Gene Tree for CCNB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNB1 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCND12  CCNA12  
    CCND22  CCNA22  
    8 SIMAP similar genes for CCNB1 using alignment to 5 protein entries:     CCNB1_HUMAN (see all proteins):
    CCNB1V    CCNE2    CCNE1    CCNB2    CCNB2V    CNTD2
    CCNA2    CCNB3

    Find genes that share paralogs with CCNB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNB1 (see all 331)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891756381,2
    --68460948(+) ATGAAA/GAAAAC 1 -- us2k10--------
    rs68670501,2
    C,F,A--68461039(+) gcactT/Ctggga 1 -- us2k15Minor allele frequency- C:0.24WA NA 244
    rs1643871,2
    C,F--68461096(+) ccgtaA/Gaagac 1 -- us2k112Minor allele frequency- G:0.50NA WA CSA EA 374
    rs1431945941,2
    --68461119(+) GTGAAC/TCTTAA 1 -- us2k10--------
    rs1512151231,2
    --68461168(+) GTAGGC/TTAACA 1 -- us2k10--------
    rs1409527181,2
    --68461237(+) ATGCTC/GTATAC 1 -- us2k10--------
    rs781911731,2
    C,F--68461295(+) GCATAT/CAAAAG 1 -- us2k12Minor allele frequency- C:0.17WA 120
    rs1924637991,2
    --68461409(+) ACATGC/GTGAAA 1 -- us2k10--------
    rs1138081031,2
    C,F--68461447(+) TTAGCT/CGGCCG 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1848263941,2
    --68461569(+) CTGGGC/TGACAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCNB1 (68462837 - 68474072 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCNB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671857CNV Deletion23128226
    nsv509066CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNB1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123836    OMIM disorders: --

    5 diseases for CCNB1:    
    About MalaCards
    adrenal carcinoma    tetraploidy    thyroid lymphoma    cervical cancer
    cholangiocarcinoma

    1 disease from the University of Copenhagen DISEASES database for CCNB1:
    Cancer

    Find genes that share disorders with CCNB1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCNB1 gene (see all 67)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 62.4 57 12883711 (3), 19666607 (3), 19223507 (3), 9030252 (3) (see all 33)
    tumors 58.6 138 12438226 (5), 19681484 (4), 19666607 (4), 10945597 (4) (see all 60)
    colon cancer 50.7 7 18671143 (1), 18097607 (1), 14613989 (1), 17390015 (1) (see all 6)
    breast cancer 50.5 35 19470724 (5), 19609944 (3), 20103625 (3), 9164677 (2) (see all 22)
    retinoblastoma 50.4 6 10485490 (2), 14674679 (1), 7666202 (1), 17148439 (1) (see all 5)
    carcinoma squamous cell 44.4 19 10071250 (2), 11895914 (2), 15320491 (2), 18048386 (2) (see all 14)
    promyelocytic leukemia 41.8 1 16619512 (1)
    cervical carcinoma 41.4 2 10741643 (1), 16614707 (1)
    breast carcinoma 39.6 7 17359284 (4), 9664138 (1), 12888910 (1)
    prostate cancer 39.3 9 17513602 (3), 14613989 (2), 10854060 (1), 16762917 (1) (see all 6)

    Genetic Association Database (GAD): CCNB1
    Human Genome Epidemiology (HuGE) Navigator: CCNB1 (4 documents)
    Tumor Gene Database (TGDB): CCNB1

    Export disorders for CCNB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNB1 gene, integrated from 10 sources (see all 982):
    (articles sorted by number of sources associating them with CCNB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1. (PubMed id 12447691)1, 2, 9 Yuan J.... Strebhardt K. (Oncogene 2002)
    2. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. (PubMed id 12524548)1, 2, 9 Jackman M.... Pines J. (Nat. Cell Biol. 2003)
    3. The crystal structure of human cyclin B. (PubMed id 17495533)1, 2, 9 Petri E.T.... Basavappa R. (Cell Cycle 2007)
    4. NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry. (PubMed id 16009132)1, 2, 9 Bassermann F.... Duyster J. (Cell 2005)
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    6. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    7. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    8. Cyclin B and cyclin A confer different substrate recognition properties on CDK2. (PubMed id 17495531)1, 2 Brown N.R....Johnson L.N. (Cell Cycle 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress. (PubMed id 15181148)1, 2 Baus Charrier-Savournin F.... Dulic V. (Mol. Biol. Cell 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 891 HGNC: 1579 AceView: CCNB1 Ensembl:ENSG00000134057 euGenes: HUgn891
    ECgene: CCNB1 Kegg: 891 H-InvDB: CCNB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCNB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNB1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccnb1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNB1 gene:
    Search GeneIP for patents involving CCNB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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