External Ids for CCNA2 Gene
Previous HGNC Symbols for CCNA2 Gene
Previous GeneCards Identifiers for CCNA2 Gene
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]
GeneCards Summary for CCNA2 Gene
CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include Splenic Diffuse Red Pulp Small B-Cell Lymphoma and Lung Clear Cell Carcinoma. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA1.
UniProtKB/Swiss-Prot for CCNA2 Gene
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.