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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCNA2 Gene

protein-coding GIFtS: 71
GCID: GC04M122737

cyclin A2

(Previous symbols: CCNA, CCN1)

Explore 132 diseases affiliated with
CCNA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin A2¹ ²
CCN1¹ ² ³ ⁵
CCNA¹ ² ³ ⁵
Cyclin-A³
Cyclin-A2¹
Cyclin-A³

External Ids:	HGNC: 1578¹	Entrez Gene: 890²	Ensembl: ENSG00000145386⁷	OMIM: 123835⁵	UniProtKB: P20248³

Export aliases for CCNA2 gene to outside databases

Previous GC identifers: GC04M123663 GC04M123018 GC04M123130 GC04M123197 GC04M123096 GC04M122957 GC04M118464

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNA2:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a

dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases.

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination

of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all

tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M

transitions. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248

Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Gene Wiki entry for CCNA2 (Cyclin A2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCNA2 gene promoter:
TBP CREB TFIID ATF-2 deltaCREB Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCNA2 promoter sequence

Search SABiosciences Chromatin IP Primers for CCNA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q27

CCNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNA2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M122737: view genomic region (about GC identifiers)

Start:	122,737,599 bp from pter	End:	122,745,088 bp from pter
Size:	7,490 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248 (See protein sequence)

Recommended Name: Cyclin-A2

Size: 432 amino acids; 48551 Da

Subunit: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The

cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts

with SCAPER

Subcellular location: Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER

Developmental stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis

6/74 PDB 3D structures from and Proteopedia for CCNA2 (see all 74):

1E9H (3D)

1FIN (3D)

1FVV (3D)

1GY3 (3D)

1H1P (3D)

1H1Q (3D)

Secondary accessions: A8K7B6 Q2M3U6 Q4W5P4 Q6LER8

Explore the universe of human proteins at neXtProt for CCNA2: NX_P20248

Post-translational modifications:

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation

by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20248

CCNA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001228.1

ENSEMBL proteins:

ENSP00000274026

Reactome Protein details: P20248
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Enzo Life Sciences proteins for CCNA2
	OriGene Purified Protein: CCNA2 OriGene Protein Over-expression Lysate: CCNA2 OriGene Custom Protein Services for CCNA2
	GenScript Custom Purified and Recombinant Proteins Services for CCNA2
	Novus Biologicals CCNA2 Proteins Novus Biologicals CCNA2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCNA2
	Uscn Proteins for CCNA2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001939	female pronucleus	IEA	--
GO:0001940	male pronucleus	IEA	--
GO:0005634	nucleus	IDA	16109376
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IEA	--

CCNA2 for ontologies About GeneDecksing

CCNA2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNA2
	R&D Systems Antibodies for CCNA2 (Cyclin A2)
	Cell Signaling Technology (CST) Antibodies for CCNA2
	OriGene Antibodies (see all 2): CCNA2 OriGene Custom Antibody Services for CCNA2
	GenScript Custom Superior Antibodies Services for CCNA2
	Novus Biologicals CCNA2 Antibodies
	Abcam antibodies for CCNA2
	Uscn Antibodies for CCNA2
	ThermoFisher Antibodies for CCNA2

Assay Products for CCNA2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CCNA2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCNA2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCNA2 for domains About GeneDecksing

4 InterPro domains/families:

IPR013763 Cyclin-like

IPR006671 Cyclin_N

IPR004367 Cyclin_C

IPR014400 Cyclin_A/B/D/E

Graphical View of Domain Structure for InterPro Entry P20248

ProtoNet protein and cluster: P20248

1 Blocks protein family: IPB006670 Cyclin

UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248

Similarity: Belongs to the cyclin family. Cyclin AB subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248

Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Genatlas biochemistry entry for CCNA2:

cyclin A,complexing with CDC2,regulating late S and G2 phase of the cell cycle,putative up-regulated c-Myc target gene,

miRNA Products:		miRTarBase miRNAs that target CCNA2: hsa-mir-24 (MIRT000119), hsa-mir-146a (MIRT004017), hsa-let-7b (MIRT003999)

		OriGene 3'-UTR Clone: CCNA2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNA2
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNA2 (see all 44):
		hsa-miR-548j hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CCNA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNA2 (see all 7) OriGene shRNA RFP: CCNA2 OriGene siRNA: CCNA2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNA2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCNA2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNA2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNA2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCNA2 (NM_001237)
		Sino Biological Human cDNA Clone for CCNA2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCNA2
		Search LifeMap BioReagents cell lines for CCNA2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0019901	protein kinase binding	IEA	--

CCNA2 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for CCNA2:

Cell division defect

Increased G2M DNA content, inc

Increased cell death in DLD-1

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Ccna2^tm1.2Pisc for CCNA2
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ccna2):

cellular

embryogenesis

hematopoietic system

immune system

mortality/aging

CCNA2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/37 super-pathways (see all 37) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/16 pathways (see all 16)
Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75	Cyclin E associated events during G1/S transition	0.67
SCF(Skp2)-mediated degradation of p27/p21	0.75	Cyclin A:Cdk2-associated events at S phase entry	0.66
Switching of origins to a post-replicative state	0.70	Regulation of APC/C activators between G1/S and early anaphase	0.62
Orc1 removal from chromatin	0.70	Regulation of mitotic cell cycle	0.58

Cell cycle_Cell cycle (generic schema)

Cell cycle_Cell cycle (generic schema)	1.00	Cell cycle Regulation of G1/S transition (part 2)	0.38
Cell cycle Cell cycle (generic schema)	1.00	G0 and Early G1	0.31
Cell cycle_Regulation of G1/S transition (part 2)	0.38

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

	Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	1.00			G2 Phase	0.43
	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	0.60

IL-9 Signaling Pathways

	IL-7 Signaling Pathway	0.38			Development_Thrombopoietin-regulated cell processes	0.36
	Development Thrombopoietin-regulated cell processes	0.36

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

1.00

Development Hedgehog and PTH signaling pathways in bone and cartilage development

0.97

Pathway sources
See GeneCards unified pathways
Show all pathways

5/11 EMD Millipore Pathways for CCNA2 (see all 11)

	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Regulation of G1/S transition (part 2)
	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Regulation of G1/S transition (part 1)

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNA2 (see all 9)

	Calpain Protease Regulates Cellular Mechanics
	TOB in T-Cell Signaling
	Breast Cancer Regulation by Stathmin1
	G1-S Phase Transition
	Estrogen-mediated S-Phase Entry

1 Cell Signaling Technology (CST) Pathway for CCNA2

Cell Cycle / Checkpoint Control

5/10 GeneGo (Thomson Reuters) Pathways for CCNA2 (see all 10)

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Cell cycle Chromosome condensation in prometaphase
	DNA damage ATM/ATR regulation of G1/S checkpoint
	Development Thrombopoietin-regulated cell processes
	Cell cycle Cell cycle (generic schema)

5/14 BioSystems Pathways for CCNA2 (see all 14)

	Cell cycle
	AMPK signaling
	Integrated Pancreatic Cancer Pathway
	B Cell Receptor Signaling Pathway
	Integrated Pancreatic Cancer Pathway

5/27 Reactome Pathways for CCNA2 (see all 27)

	SCF(Skp2)-mediated degradation of p27/p21
	Mitotic G1-G1/S phases
	DNA Replication
	G0 and Early G1
	Removal of licensing factors from origins

2 Kegg Pathways (Kegg details for CCNA2):

	Cell cycle
	Progesterone-mediated oocyte maturation

CCNA2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCNA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/110 Interacting proteins for CCNA2 (P20248^{1, 2, 3} ENSP00000274026⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 110)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4L	P62805³, ENSP00000348258⁴	I2D: score=1 STRING: ENSP00000348258
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	IEA	--
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007067	mitosis	IEA	--
GO:0007095	mitotic cell cycle G2/M transition DNA damage checkpoint	TAS	1312467

CCNA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCNA2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for CCNA2

Browse Tocris compounds for CCNA2

10/33 DrugBank Compounds for CCNA2 (see all 33) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol	--	--	target	--	10592235
(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol	--	--	target	--	10592235
(2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE	--	--	target	--	10592235
1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID	--	--	target	--	10592235
1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE	--	--	target	--	10592235
1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid	--	--	target	--	10592235
2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE	--	--	target	--	10592235
3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE	--	--	target	--	10592235
3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL	--	--	target	--	10592235
4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(4-Trifluoromethyl-Phenyl)-Amine	--	--	target	--	10592235

10/122 Novoseek chemical compound relationships for CCNA2 gene (see all 122) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
olomoucine	71.5	2	7925396 (1), 7549905 (1)
roscovitine	61.5	1	18574471 (1)
mimosine	58.5	6	1386764 (1), 1423313 (1), 10788489 (1), 7628532 (1) (see all 5)
thymidine	53.5	16	9831241 (2), 15694027 (2), 8475104 (1), 15963470 (1) (see all 14)
bromodeoxyuridine	52.7	35	11016684 (7), 9041174 (4), 10942581 (3), 8822203 (2) (see all 15)
pstair	51	3	1533642 (2), 2143983 (1)
flavopiridol	47.7	5	12467221 (1), 12457721 (1), 15185335 (1), 19603446 (1) (see all 5)
aphidicolin	47.6	3	1423313 (1), 11282082 (1), 14738865 (1)
butyrolactone i	42	1	9703910 (1)
mg 132	38.4	2	15010833 (1), 15147952 (1)

Search CenterWatch for drugs/clinical trials and news about CCNA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCNA2 gene:

NM_001237.3

Unigene Cluster for CCNA2:

Cyclin A2

Hs.58974 [show with all ESTs]

Unigene Representative Sequence: NM_001237

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000274026(uc003iec.4)

miRNA Products:		OriGene 3'-UTR Clone: CCNA2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNA2
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNA2 (see all 44):
		hsa-miR-548j hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CCNA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCNA2 (see all 7) OriGene shRNA RFP: CCNA2 OriGene siRNA: CCNA2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNA2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCNA2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCNA2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCNA2 (NM_001237)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNA2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCNA2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNA2

Additional cDNA sequence:

AK291931.1 BC104783.1 BC104787.1 CR407692.1 X51688.1

10 DOTS entries:

DT.455397 DT.407371 DT.100796206 DT.95341715 DT.95341757 DT.100796211 DT.100648874 DT.121256957

DT.99965390 DT.101957287

24/221 AceView cDNA sequences (see all 221):

BE313253 AA747548 BU733834 CB132319 BM480005 CA430513 AI421226 BG031146

BM754344 BU902535 BG421540 AA580754 AA214552 AW575658 D11598 AI624917

AI141961 AA424282 CR597266 CR604810 BX421177 BM709790 D11599 CA430303

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCNA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCAAGATG

About this image

CCNA2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

S-shaped Body

Kidney Endothelial Cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

Adult human kidney epithelial cells (Primary Cell)

Kidney

See CCNA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCNA2

SOURCE GeneReport for Unigene cluster: Hs.58974

SABiosciences Expression via Pathway-Focused PCR Arrays including CCNA2:

Cell Cycle in human mouse rat

Cellular Senescence in human mouse rat

MAP Kinase (MAPK) Signaling Pathway in human mouse rat

Stem Cells in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCNA2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCNA2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNA2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA2 gene from 7/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCNA2¹	cyclin A2	67.95(n) 70.51(a)		396172 NM_205244.1 NP_990575.1
lizard (Anolis carolinensis)	Reptilia	CCNA2⁶	--	72(a)	1 ↔ 1	5(139042627-139049468)
African clawed frog (Xenopus laevis)	Amphibia	LOC397933²	cyclin A2	75.77(n)		X85746.1
zebrafish (Danio rerio)	Actinopterygii	ccna2²	cyclin A2	78.73(n)		192295 AF234784.2
fruit fly (Drosophila melanogaster)	Insecta	CycA^{1 , 3}	mitosis cyclin-dependent protein kinase, regulator³ Cyclin A¹	49(a)³ 52.83(n)¹ 49.8(a)¹		68E1³ 39340¹ NM_079306.3¹ NP_524030.2¹
thale cress (Arabidopsis thaliana)	eudicotyledons	CYCA2;4¹	cyclin-A2-4	47.55(n) 41.64(a)		844377 NM_106686.2 NP_178153.1
rice (Oryza sativa)	Liliopsida	Os12g0502300¹	hypothetical protein	52.21(n) 46.18(a)		4352280 NM_001073360.1 NP_001066828.1

ENSEMBL Gene Tree for CCNA2 (if available)
TreeFam Gene Tree for CCNA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CCNA2 gene

CCND3² CCNO² CCNE1² CCNB2² CCNE2² CCNB3² CCNB1² CCND1²

CCNA1² CCND2²

4 SIMAP similar genes for CCNA2 using alignment to 1 protein entry: CCNA2_HUMAN:

CCNA1 CCNB2 CCNB1 CCNB1V

CCNA2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3217782^1,2	C,F,	--	118463843(-)	`TGACAG/AAGCAA`	2	--	int¹		1	NS	180
rs113448823^1,2	C,	--	118463865(+)	`GTGCAG/TTGGCA`	2	--	int¹		1	WA	2
rs3217781^1,2	C,F,H,	--	118463928(-)	`AGGCCC/TAGCTA`	2	--	int¹		6	NS EA WA	710
rs13117978^1,2	H	--	118464421(+)	`ATCTGT/GTCTGT`	2	--	int¹		4	NS EA	410
rs13117986^1,2	H	--	118464426(+)	`TTCTGT/GGATTT`	2	--	int¹		4	NS EA	416
rs72915963^1,2	C,	--	118464513(+)	`TGACAC/TATTTT`	2	--	int¹		2	WA	120
rs112004858^1,2	F	--	118464538(+)	`AACTAG/AGAAAT`	2	--	int¹		1	CSA	6
rs3217779^1,2	C,	--	118464816(-)	`AAAAAA/GCTATT`	2	--	ut3¹		2	NS EA	294
rs3217778^1,2	C,H,	--	118464994(-)	`AGAGAT/CAGATA`	2	--	ds500¹		5	NS EA	574
rs3217777^1,2	C,H	--	118465268(-)	`TAAGTG/AGTTTT`	2	--	ds500¹		5	NS EA	588

HapMap Linkage Disequilibrium report for CCNA2 (122737599 - 122745088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCNA2: --
Human Gene Mutation Database (HGMD): CCNA2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCNA2

DNA2.0 Custom Variant and Variant Library Synthesis for CCNA2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCNA2 for disorders           About GeneDecksing

OMIM gene information: 123835    OMIM disorders: --

20/132 diseases for CCNA2 (see all 132):    About MalaCards

estrogen-receptor positive breast cancer malignant fibrous histiocytoma smooth muscle tumor fibrous histiocytoma

diffuse large b-cell lymphoma tenosynovial giant cell tumor squamous cell carcinoma non-small cell lung carcinoma

adenomatous polyposis coli b-cell lymphomas germ cell tumor laryngeal squamous cell carcinoma

temporal lobe epilepsy anaplastic large cell lymphoma testicular germ cell tumor male germ cell tumor

actinic keratosis non-hodgkin lymphoma giant cell tumor soft tissue sarcoma

10/97 Novoseek disease relationships for CCNA2 gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	85.9	89	15187102 (2), 19706764 (2), 1323816 (2), 14681231 (2) (see all 81)
tumors	61.1	199	9500460 (5), 9815824 (4), 9796723 (4), 11277408 (4) (see all 99)
cancer	57.9	69	14719102 (3), 14510182 (2), 8318919 (2), 19686820 (2) (see all 47)
breast cancer	47.1	55	19706846 (5), 16823179 (4), 18665474 (4), 17201163 (3) (see all 30)
superficial spreading malignant melanoma	46.8	1	11745687 (1)
hepatocellular carcinoma	42.1	18	14606074 (2), 10408900 (2), 9500460 (2), 12408762 (2) (see all 14)
carcinoma	41.6	49	11444193 (4), 9950254 (3), 12395374 (3), 17593077 (2) (see all 28)
carcinoma squamous cell	40.3	27	12406568 (2), 19567385 (2), 11503976 (2), 12654186 (2) (see all 18)
colon carcinoma	39.9	1	7601562 (1)
colon cancer	38.6	1	20029639 (1)

Human Genome Epidemiology (HuGE) Navigator: CCNA2 (9 documents)

Export disorders for CCNA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCNA2 gene, integrated from 9 sources (see all 1312):
(articles sorted by number of sources associating them with CCNA2)

Utopia: connect your pdf to the dynamic
world of online information

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PubMed id 21596315)^{1, 2} Huang X.... Dixit V.M. (2011)
SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. (PubMed id 17698606)^{1, 2} Tsang W.Y....Dynlacht B.D. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structural basis of cyclin-dependent kinase activation by phosphorylation. (PubMed id 8756328)^{1, 2} Russo A.A.... Pavletich N.P. (1996)
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. (PubMed id 8684460)^{1, 2} Russo A.A.... Pavletich N.P. (1996)
Mechanism of CDK activation revealed by the structure of a cyclinA- CDK2 complex. (PubMed id 7630397)^{1, 2} Jeffrey P.D.... Pavletich N.P. (1995)
Structure and cell cycle-regulated transcription of the human cyclin A gene. (PubMed id 8202514)^{1, 2} Henglein B.... Brechot C. (1994)
A TaqI polymorphism in the human cyclin A gene. (PubMed id 1675006)^{1, 3} Paterlini P....Brechot C. (1991)
Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. (PubMed id 1967822)^{1, 2} Wang J.... Brechot C. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 890	HGNC: 1578	AceView: CCNA2	Ensembl:ENSG00000145386	euGenes: HUgn890
ECgene: CCNA2	Kegg: 890	H-InvDB: CCNA2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCNA2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCNA2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccna2/

Intellectual Property for CCNA2 gene
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Patent Information for CCNA2 gene:
Search GeneIP for patents involving CCNA2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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cyclin A2

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