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Aliases for CCNA2 Gene

Aliases for CCNA2 Gene

  • Cyclin A2 2 3
  • CCN1 3 4 6
  • CCNA 3 4 6
  • Cyclin-A 3 4
  • Cyclin-A2 3

External Ids for CCNA2 Gene

Previous HGNC Symbols for CCNA2 Gene

  • CCNA
  • CCN1

Previous GeneCards Identifiers for CCNA2 Gene

  • GC04M123663
  • GC04M123018
  • GC04M123130
  • GC04M123197
  • GC04M123096
  • GC04M122957
  • GC04M122737
  • GC04M118464

Summaries for CCNA2 Gene

Entrez Gene Summary for CCNA2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNA2 Gene

CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include tenosynovial giant cell tumor and benign meningioma. Among its related pathways are GPCR Pathway and GPCR Pathway. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNA2 Gene

  • Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Gene Wiki entry for CCNA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNA2 Gene

Genomics for CCNA2 Gene

Regulatory Elements for CCNA2 Gene

Genomic Location for CCNA2 Gene

Start:
121,816,444 bp from pter
End:
121,823,933 bp from pter
Size:
7,490 bases
Orientation:
Minus strand

Genomic View for CCNA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNA2 Gene

Proteins for CCNA2 Gene

  • Protein details for CCNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20248-CCNA2_HUMAN
    Recommended name:
    Cyclin-A2
    Protein Accession:
    P20248
    Secondary Accessions:
    • A8K7B6
    • Q2M3U6
    • Q4W5P4
    • Q6LER8

    Protein attributes for CCNA2 Gene

    Size:
    432 amino acids
    Molecular mass:
    48551 Da
    Quaternary structure:
    • Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER. Interacts with human cytomegalovirus protein UL32 (PubMed:24101496).

    Three dimensional structures from OCA and Proteopedia for CCNA2 Gene

neXtProt entry for CCNA2 Gene

Proteomics data for CCNA2 Gene at MOPED

Post-translational modifications for CCNA2 Gene

  • Polyubiquitinated via Lys-11-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity).
  • Ubiquitination at Lys54
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNA2 Gene

Domains for CCNA2 Gene

Protein Domains for CCNA2 Gene

Suggested Antigen Peptide Sequences for CCNA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20248

UniProtKB/Swiss-Prot:

CCNA2_HUMAN :
  • P20248
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNA2: view

No data available for Gene Families for CCNA2 Gene

Function for CCNA2 Gene

Molecular function for CCNA2 Gene

GENATLAS Biochemistry: cyclin A,complexing with CDC2,regulating late S and G2 phase of the cell cycle,putative up-regulated c-Myc target gene,
UniProtKB/Swiss-Prot Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Gene Ontology (GO) - Molecular Function for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNA2: view
genes like me logo Genes that share phenotypes with CCNA2: view

Animal Models for CCNA2 Gene

MGI Knock Outs for CCNA2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCNA2 Gene

Localization for CCNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNA2 Gene

Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNA2 Gene COMPARTMENTS Subcellular localization image for CCNA2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001939 female pronucleus IEA --
GO:0001940 male pronucleus IEA --
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 23791195
genes like me logo Genes that share ontologies with CCNA2: view

Pathways for CCNA2 Gene

genes like me logo Genes that share pathways with CCNA2: view

Gene Ontology (GO) - Biological Process for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007095 mitotic G2 DNA damage checkpoint TAS 1312467
genes like me logo Genes that share ontologies with CCNA2: view

Compounds for CCNA2 Gene

(122) Novoseek inferred chemical compound relationships for CCNA2 Gene

Compound -log(P) Hits PubMed IDs
olomoucine 71.5 2
roscovitine 61.5 1
mimosine 58.5 5
thymidine 53.5 16
bromodeoxyuridine 52.7 27
genes like me logo Genes that share compounds with CCNA2: view

Transcripts for CCNA2 Gene

mRNA/cDNA for CCNA2 Gene

Unigene Clusters for CCNA2 Gene

Cyclin A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNA2 Gene

No ASD Table

Relevant External Links for CCNA2 Gene

GeneLoc Exon Structure for
CCNA2
ECgene alternative splicing isoforms for
CCNA2

Expression for CCNA2 Gene

mRNA expression in normal human tissues for CCNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNA2 Gene

SOURCE GeneReport for Unigene cluster for CCNA2 Gene Hs.58974

genes like me logo Genes that share expressions with CCNA2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCNA2 Gene

Orthologs for CCNA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNA2 35
  • 99.46 (n)
  • 99.54 (a)
CCNA2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNA2 35
  • 90.62 (n)
  • 90.7 (a)
CCNA2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNA2 35
  • 91.82 (n)
  • 91.44 (a)
CCNA2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccna2 35
  • 86.65 (n)
  • 89.32 (a)
Ccna2 16
Ccna2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCNA2 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccna2 35
  • 87.85 (n)
  • 89.69 (a)
chicken
(Gallus gallus)
Aves CCNA2 35
  • 68.21 (n)
  • 70.95 (a)
CCNA2 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNA2 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397933 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccna2 35
  • 65.08 (n)
  • 64.91 (a)
Str.6336 35
zebrafish
(Danio rerio)
Actinopterygii ccna2 35
  • 65.03 (n)
  • 66.24 (a)
ccna2 36
  • 49 (a)
OneToMany
CCNA2 (2 of 2) 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012413 35
  • 57.14 (n)
  • 56.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycA 35
  • 52.83 (n)
  • 49.8 (a)
CycA 36
  • 31 (a)
OneToMany
CycA 37
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK507.6 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLN1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCA2;4 35
  • 47.65 (n)
  • 39.95 (a)
rice
(Oryza sativa)
Liliopsida Os12g0502300 35
  • 51.94 (n)
  • 46.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10122 36
  • 58 (a)
OneToMany
Species with no ortholog for CCNA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNA2 Gene

ENSEMBL:
Gene Tree for CCNA2 (if available)
TreeFam:
Gene Tree for CCNA2 (if available)

Paralogs for CCNA2 Gene

Paralogs for CCNA2 Gene

Selected SIMAP similar genes for CCNA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCNA2: view

Variants for CCNA2 Gene

Sequence variations from dbSNP and Humsavar for CCNA2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs769237 -- 121,823,824(-) CCTGC(C/T)TGCGC utr-variant-5-prime
rs769238 -- 121,823,787(-) GGTCT(C/T)GAGCT utr-variant-5-prime
rs769239 -- 121,823,753(-) TAGGC(C/T)GGCCT utr-variant-5-prime
rs769240 -- 121,822,912(-) TAAAC(G/T)TGTCA intron-variant
rs769241 -- 121,821,142(-) CTATT(A/G)AACTA intron-variant

Relevant External Links for CCNA2 Gene

HapMap Linkage Disequilibrium report
CCNA2
Human Gene Mutation Database (HGMD)
CCNA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCNA2 Gene

Disorders for CCNA2 Gene

(97) Novoseek inferred disease relationships for CCNA2 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 85.9 86
tumors 61.1 132
cancer 57.9 58
breast cancer 47.1 50
superficial spreading malignant melanoma 46.8 1

Relevant External Links for CCNA2

Genetic Association Database (GAD)
CCNA2
Human Genome Epidemiology (HuGE) Navigator
CCNA2
genes like me logo Genes that share disorders with CCNA2: view

No data available for UniProtKB/Swiss-Prot for CCNA2 Gene

Publications for CCNA2 Gene

  1. Modulation of cell cycle control by vitamin D3 and its analogue, EB1089, in human breast cancer cells. (PMID: 9380407) Wu G. … Brattain M.G. (Oncogene 1997) 3 23
  2. Cyclin A and the retinoblastoma gene product complex with a common transcription factor. (PMID: 1830372) Bandara L.R. … La Thangue N.B. (Nature 1991) 3 23
  3. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. (PMID: 8253383) Li Y. … Whyte P. (Genes Dev. 1993) 3 23
  4. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. (PMID: 1532458) Faha B. … Harlow E. (Science 1992) 3 23
  5. G1 expression and multistage dynamics of cyclin A in human osteosarcoma cells. (PMID: 8502485) Carbonaro-Hall D. … Hall F. (Oncogene 1993) 3 23

Products for CCNA2 Gene

  • Addgene plasmids for CCNA2

Sources for CCNA2 Gene

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