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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCNA2 Gene

protein-coding   GIFtS: 71
GCID: GC04M122737

Cyclin A2


(Previous symbols: CCNA, CCN1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin A21 2
CCN11 2 3 5
CCNA1 2 3 5
cyclin-A2
cyclin-A22
Cyclin-A3

External Ids:    HGNC: 15781   Entrez Gene: 8902   Ensembl: ENSG000001453867   OMIM: 1238355   UniProtKB: P202483   

Export aliases for CCNA2 gene to outside databases

Previous GC identifers: GC04M123663 GC04M123018 GC04M123130 GC04M123197 GC04M123096 GC04M122957 GC04M118464


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCNA2 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is
expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both
cell cycle G1/S and G2/M transitions. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNA2 Gene: 
CCNA2 (cyclin A2) is a protein-coding gene. Diseases associated with CCNA2 include pleomorphic adenoma carcinoma, and thyroid lymphoma, and among its related super-pathways are Cell cycle Role of SCF complex in cell cycle regulation and Cell cycle Transition and termination of DNA replication. GO annotations related to this gene include protein binding and protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248
Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Gene Wiki entry for CCNA2 (Cyclin A2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCNA2 gene promoter:
         TBP   CREB   TFIID   ATF-2   deltaCREB   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCNA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCNA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q27

CCNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNA2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M122737:  view genomic region     (about GC identifiers)

Start:
122,737,599 bp from pter      End:
122,745,088 bp from pter
Size:
7,490 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248 (See protein sequence)
Recommended Name: Cyclin-A2  
Size: 432 amino acids; 48551 Da
Subunit: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex.
The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1),
interacts with SCAPER
Subcellular location: Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER
Developmental stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis
6/79 PDB 3D structures from and Proteopedia for CCNA2 (see all 79):
1E9H (3D)        1FIN (3D)        1FVV (3D)        1GY3 (3D)        1H1P (3D)        1H1Q (3D)    
Secondary accessions: A8K7B6 Q2M3U6 Q4W5P4 Q6LER8

Explore the universe of human proteins at neXtProt for CCNA2: NX_P20248

Explore proteomics data for CCNA2 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its
    degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20248

  • CCNA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCNA2 Protein Expression
    REFSEQ proteins: NP_001228.1  
    ENSEMBL proteins: 
     ENSP00000274026  
    Reactome Protein details: P20248
    Human Recombinant Protein Products for CCNA2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for CCNA2
    OriGene Purified Protein for CCNA2
    OriGene Protein Over-expression Lysate for CCNA2
    OriGene MassSpec for CCNA2 
    OriGene Custom Protein Services for CCNA2
    GenScript Custom Purified and Recombinant Proteins Services for CCNA2
    Novus Biologicals CCNA2 Proteins
    Novus Biologicals CCNA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCNA2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001939female pronucleus IEA--
    GO:0001940male pronucleus IEA--
    GO:0005634nucleus IDA16109376
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    CCNA2 for ontologies           About GeneDecksing



    CCNA2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNA2
    R&D Systems Antibodies for CCNA2 (Cyclin A2)
    Cell Signaling Technology (CST) Antibodies for CCNA2 
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    OriGene Custom Antibody Services for CCNA2
    GenScript Custom Superior Antibodies Services for CCNA2
    Novus Biologicals CCNA2 Antibodies
    Abcam antibodies for CCNA2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CCNA2
    LSBio Antibodies in human, mouse, rat for CCNA2 

    Assay Products for CCNA2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCNA2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCNA2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P20248

    ProtoNet protein and cluster: P20248

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily


    CCNA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNA2_HUMAN, P20248
    Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

         Genatlas biochemistry entry for CCNA2:
    cyclin A,complexing with CDC2,regulating late S and G2 phase of the cell cycle,putative up-regulated c-Myc target
    gene,

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019901protein kinase binding IEA--
         
    CCNA2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CCNA2:
     Cell division defect  Increased G2M DNA content, inc  Increased cell death in DLD-1   Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccna2):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 

    CCNA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccna2tm1.2Pisc for CCNA2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCNA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCNA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCNA2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCNA2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCNA2:
    hsa-mir-24 (MIRT000119), hsa-mir-146a (MIRT004017), hsa-let-7b (MIRT003999)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCNA2
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNA2 (see all 44):
    hsa-miR-548j hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCNA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCNA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCNA2
    Sirion Biotech Customized adenovirus for overexpression of CCNA2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCNA2 (see all 7)
    OriGene ORF clones in mouse, rat for CCNA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCNA2 (NM_001237)
    Sino Biological Human cDNA Clone for CCNA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA2
    Sirion Biotech Customized lentivirus for stable overexpression of CCNA2 
                         Customized lentivirus expression plasmids for stable overexpression of CCNA2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CCNA2
    Search LifeMap BioReagents cell lines for CCNA2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCNA2 About   (see all 38)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle Cell cycle (generic schema)
    Cell cycle Regulation of G1/S transition (part 1)0.39
    Cell cycle ESR1 regulation of G1/S transition0.33
    Cell cycle Cell cycle (generic schema)0.38
    G0 and Early G10.31
    Cell cycle Regulation of G1/S transition (part 2)0.38
    2Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replication0.95
    Cell cycle Transition and termination of DNA replacation0.95
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-7 Signaling Pathway0.40
    Development Thrombopoietin-regulated cell processes0.38
    5CDK-mediated phosphorylation and removal of Cdc6
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    Cyclin E associated events during G1/S transition 0.89
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Orc1 removal from chromatin0.89
    APC/C-mediated degradation of cell cycle proteins0.94
    Switching of origins to a post-replicative state0.89
    Regulation of mitotic cell cycle0.94
    Cyclin A:Cdk2-associated events at S phase entry0.88

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/11 EMD Millipore Pathways for CCNA2 (see all 11)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCNA2 (see all 9)
        Calpain Protease Regulates Cellular Mechanics
    TOB in T-Cell Signaling
    Breast Cancer Regulation by Stathmin1
    G1-S Phase Transition
    Estrogen-mediated S-Phase Entry

    1 Cell Signaling Technology (CST) Pathway for CCNA2
        Cell Cycle / Checkpoint Control

    5/10 GeneGo (Thomson Reuters) Pathways for CCNA2 (see all 10)
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Cell cycle Chromosome condensation in prometaphase
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Development Thrombopoietin-regulated cell processes
    Cell cycle Cell cycle (generic schema)

    5/13 BioSystems Pathways for CCNA2 (see all 13)
        Cell cycle
    AMPK signaling
    IL-7 Signaling Pathway
    Id Signaling Pathway
    B Cell Receptor Signaling Pathway


    5/24        Reactome Pathways for CCNA2 (see all 24)
        SCF(Skp2)-mediated degradation of p27/p21
    Mitotic G1-G1/S phases
    DNA Replication
    G0 and Early G1
    Removal of licensing factors from origins


    5         Kegg Pathways  (Kegg details for CCNA2):
        Cell cycle
    Progesterone-mediated oocyte maturation
    Hepatitis B
    Epstein-Barr virus infection
    Viral carcinogenesis


    CCNA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCNA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/110 Interacting proteins for CCNA2 (P202481, 2, 3 ENSP000002740264) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007095mitotic G2 DNA damage checkpoint TAS1312467

    CCNA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCNA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CCNA2

    Browse Tocris compounds for CCNA2

    10/33 DrugBank Compounds for CCNA2 (see all 33)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol-- --target--10592235
    (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol-- --target--10592235
    (2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE-- --target--10592235
    1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID-- --target--10592235
    1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE-- --target--10592235
    1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid-- --target--10592235
    2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE-- --target--10592235
    3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE-- --target--10592235
    3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL-- --target--10592235
    4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(4-Trifluoromethyl-Phenyl)-Amine-- --target--10592235

    10/122 Novoseek inferred chemical compound relationships for CCNA2 gene (see all 122)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    olomoucine 71.5 2 7925396 (1), 7549905 (1)
    roscovitine 61.5 1 18574471 (1)
    mimosine 58.5 6 1386764 (1), 1423313 (1), 10788489 (1), 7628532 (1) (see all 5)
    thymidine 53.5 16 9831241 (2), 15694027 (2), 8475104 (1), 15963470 (1) (see all 14)
    bromodeoxyuridine 52.7 35 11016684 (7), 9041174 (4), 10942581 (3), 8822203 (2) (see all 15)
    pstair 51 3 1533642 (2), 2143983 (1)
    flavopiridol 47.7 5 12467221 (1), 12457721 (1), 15185335 (1), 19603446 (1) (see all 5)
    aphidicolin 47.6 3 1423313 (1), 11282082 (1), 14738865 (1)
    butyrolactone i 42 1 9703910 (1)
    mg 132 38.4 2 15010833 (1), 15147952 (1)

    Search CenterWatch for drugs/clinical trials and news about CCNA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCNA2 gene: 
    NM_001237.3  

    Unigene Cluster for CCNA2:

    Cyclin A2
    Hs.58974  [show with all ESTs]
    Unigene Representative Sequence: NM_001237
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274026(uc003iec.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CCNA2 (see all 44):
    hsa-miR-548j hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCNA2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCNA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCNA2
    Clone
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    OriGene clones in human, mouse for CCNA2 (see all 7)
    OriGene ORF clones in mouse, rat for CCNA2
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    GenScript: all cDNA clones in your preferred vector: CCNA2 (NM_001237)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA2
    Sirion Biotech Customized lentivirus for stable overexpression of CCNA2 
                         Customized lentivirus expression plasmids for stable overexpression of CCNA2 
    Primer
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    OriGene qPCR primer pairs and template standards for CCNA2
    OriGene qSTAR qPCR primer pairs in human, mouse for CCNA2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCNA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCNA2

    Additional mRNA sequence: 

    AK291931.1 BC104783.1 BC104787.1 CR407692.1 X51688.1 

    10 DOTS entries:

    DT.455397  DT.407371  DT.100796206  DT.95341715  DT.95341757  DT.100796211  DT.100648874  DT.121256957 
    DT.99965390  DT.101957287 

    24/221 AceView cDNA sequences (see all 221):

    CB132319 BM754344 BI916229 AA214552 CR592551 AA747548 BX421177 BG421540 
    AA424282 BE889788 BU165700 BM709790 AI624917 CB148121 BU902535 AW575658 
    D11598 BM478693 D11599 CR597266 BU733834 CR619143 BQ888303 BG031146 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCNA2 expression in normal human tissues (normalized intensities)      CCNA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCAAGATG
    CCNA2 Expression
    About this image


    CCNA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Thalamus
             Septum   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See CCNA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCNA2

    SOURCE GeneReport for Unigene cluster: Hs.58974
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCNA2: 
              Cell Cycle in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNA2 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccna21 , 5 cyclin A21, 5 86.65(n)1
    89.32(a)1
      3 (17.67 cM)5
    124281  NM_009828.21  NP_033958.21 
     365648665 
    chicken
    (Gallus gallus)
    Aves CCNA21 cyclin A2 67.95(n)
    70.51(a)
      396172  NM_205244.1  NP_990575.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNA26
    Uncharacterized protein
    74(a)
    1 ↔ 1
    5(139042537-139049515)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979332 cyclin A2 75.77(n)    X85746.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccna22 cyclin A2 78.73(n)   192295  AF234784.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycA1 , 3 mitosis cyclin-dependent protein
    kinase, regulator3
    Cyclin A1
    49(a)3
    52.83(n)1
    49.8(a)1
      68E13
    393401  NM_079306.31  NP_524030.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLN1(YMR199W)4 G1 cyclin involved in regulation of the cell cycle; more   --   13(662644-664284) 855239  NP_013926.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYCA2;41 cyclin-A2-4 47.55(n)
    41.64(a)
      844377  NM_106686.2  NP_178153.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g05023001 hypothetical protein 52.21(n)
    46.18(a)
      4352280  NM_001073360.1  NP_001066828.1 


    ENSEMBL Gene Tree for CCNA2 (if available)
    TreeFam Gene Tree for CCNA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCNA2 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  
    CCNA12  CCND22  
    4 SIMAP similar genes for CCNA2 using alignment to 1 protein entry:     CCNA2_HUMAN:
    CCNA1    CCNB2    CCNB1    CCNB1V

    CCNA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/146 SNPs in CCNA2 are shown (see all 146)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0188194
    ----see VAR_0188192 I V mis40--------
    rs1995244061,2
    C--122738801(+) CAGATA/TTAGTG 2 N Y mis10--------
    rs3759516621,2
    C--122738823(+) TTGAGC/G/TAGAGA 3 L syn10--------
    rs1998113921,2
    C--122738851(+) AAGTAA/C/GGGAAA 1 -- int11EU 1321
    rs1815200271,2
    C--122738854(+) TAGGGA/GAAAAA 1 -- int11Minor allele frequency- G:0.00EU 1321
    rs2014667751,2
    C--122738869(+) CATTTG/TTAGTA 1 -- int10--------
    rs32177761,2
    C,F,H--122738957(-) CAAGTC/TGGTCA 1 -- int15Minor allele frequency- T:0.00NS EA 578
    rs1148996571,2
    F--122738973(+) TTTAGA/GAACAC 1 -- int11Minor allele frequency- G:0.02WA 118
    rs32177751,2
    H--122738995(-) TGTGTG/ATTTCA 1 -- int15Minor allele frequency- A:0.00NS EA 578
    rs7692531,2
    C,H--122739090(-) GCYGTT/CCTCTA 1 -- int110Minor allele frequency- C:0.00NA MN NS EA 988

    HapMap Linkage Disequilibrium report for CCNA2 (122737599 - 122745088 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCNA2: --

    Human Gene Mutation Database (HGMD): CCNA2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CCNA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123835    OMIM disorders: --

    20/112 diseases for CCNA2 (see all 112):    About MalaCards
    pleomorphic adenoma carcinoma    thyroid lymphoma    tenosynovial giant cell tumor    pleomorphic adenoma
    phyllode tumor    breast adenocarcinoma    myxofibrosarcoma    actinic keratosis
    benign meningioma    smooth muscle tumor    giant cell tumor    laryngeal squamous cell carcinoma
    histiocytoma    colon adenocarcinoma    fibrous histiocytoma    oral cancer
    germ cell tumors    anaplastic astrocytoma    keratoacanthoma    laryngitis


    CCNA2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for CCNA2 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 85.9 89 15187102 (2), 19706764 (2), 1323816 (2), 14681231 (2) (see all 81)
    tumors 61.1 199 9500460 (5), 9815824 (4), 9796723 (4), 11277408 (4) (see all 99)
    cancer 57.9 69 14719102 (3), 14510182 (2), 8318919 (2), 19686820 (2) (see all 47)
    breast cancer 47.1 55 19706846 (5), 16823179 (4), 18665474 (4), 17201163 (3) (see all 30)
    superficial spreading malignant melanoma 46.8 1 11745687 (1)
    hepatocellular carcinoma 42.1 18 14606074 (2), 10408900 (2), 9500460 (2), 12408762 (2) (see all 14)
    carcinoma 41.6 49 11444193 (4), 9950254 (3), 12395374 (3), 17593077 (2) (see all 28)
    carcinoma squamous cell 40.3 27 12406568 (2), 19567385 (2), 11503976 (2), 12654186 (2) (see all 18)
    colon carcinoma 39.9 1 7601562 (1)
    colon cancer 38.6 1 20029639 (1)

    Genetic Association Database (GAD): CCNA2
    Human Genome Epidemiology (HuGE) Navigator: CCNA2 (9 documents)

    Export disorders for CCNA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCNA2 gene, integrated from 9 sources (see all 1338):
    (articles sorted by number of sources associating them with CCNA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PubMed id 21596315)1, 2 Huang X.... Dixit V.M. (2011)
    2. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    6. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    7. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Fridley B.L. (2009)
    8. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    9. SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. (PubMed id 17698606)1, 2 Tsang W.Y....Dynlacht B.D. (2007)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 890 HGNC: 1578 AceView: CCNA2 Ensembl:ENSG00000145386 euGenes: HUgn890
    ECgene: CCNA2 Kegg: 890 H-InvDB: CCNA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCNA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNA2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccna2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCNA2 gene:
    Search GeneIP for patents involving CCNA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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