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Aliases for CCNA2 Gene

Aliases for CCNA2 Gene

  • Cyclin A2 2 3
  • CCN1 3 4 6
  • CCNA 3 4 6
  • Cyclin-A 3 4
  • Cyclin-A2 3

External Ids for CCNA2 Gene

Previous HGNC Symbols for CCNA2 Gene

  • CCNA
  • CCN1

Previous GeneCards Identifiers for CCNA2 Gene

  • GC04M123663
  • GC04M123018
  • GC04M123130
  • GC04M123197
  • GC04M123096
  • GC04M122957
  • GC04M122737
  • GC04M118464

Summaries for CCNA2 Gene

Entrez Gene Summary for CCNA2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNA2 Gene

CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include tenosynovial giant cell tumor and benign meningioma. Among its related pathways are GPCR Pathway and GPCR Pathway. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNA2 Gene

  • Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Gene Wiki entry for CCNA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNA2 Gene

Genomics for CCNA2 Gene

Regulatory Elements for CCNA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNA2 Gene

121,816,444 bp from pter
121,823,933 bp from pter
7,490 bases
Minus strand

Genomic View for CCNA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNA2 Gene

Proteins for CCNA2 Gene

  • Protein details for CCNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K7B6
    • Q2M3U6
    • Q4W5P4
    • Q6LER8

    Protein attributes for CCNA2 Gene

    432 amino acids
    Molecular mass:
    48551 Da
    Quaternary structure:
    • Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER. Interacts with human cytomegalovirus protein UL32 (PubMed:24101496).

    Three dimensional structures from OCA and Proteopedia for CCNA2 Gene

neXtProt entry for CCNA2 Gene

Proteomics data for CCNA2 Gene at MOPED

Post-translational modifications for CCNA2 Gene

  • Polyubiquitinated via Lys-11-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity).
  • Ubiquitination at Lys54
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNA2 Gene

Domains for CCNA2 Gene

Gene Families for CCNA2 Gene

Protein Domains for CCNA2 Gene

Suggested Antigen Peptide Sequences for CCNA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin AB subfamily.
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNA2: view

Function for CCNA2 Gene

Molecular function for CCNA2 Gene

GENATLAS Biochemistry:
cyclin A,complexing with CDC2,regulating late S and G2 phase of the cell cycle,putative up-regulated c-Myc target gene,
UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Gene Ontology (GO) - Molecular Function for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNA2: view
genes like me logo Genes that share phenotypes with CCNA2: view

Animal Models for CCNA2 Gene

MGI Knock Outs for CCNA2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCNA2 Gene

Localization for CCNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNA2 Gene

Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER.

Subcellular locations from

Jensen Localization Image for CCNA2 Gene COMPARTMENTS Subcellular localization image for CCNA2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001939 female pronucleus IEA --
GO:0001940 male pronucleus IEA --
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 23791195
genes like me logo Genes that share ontologies with CCNA2: view

Pathways for CCNA2 Gene

genes like me logo Genes that share pathways with CCNA2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007095 mitotic G2 DNA damage checkpoint TAS 1312467
genes like me logo Genes that share ontologies with CCNA2: view

Drugs for CCNA2 Gene

(122) Novoseek inferred chemical compound relationships for CCNA2 Gene

Compound -log(P) Hits PubMed IDs
olomoucine 71.5 2
roscovitine 61.5 1
mimosine 58.5 5
thymidine 53.5 16
bromodeoxyuridine 52.7 27
genes like me logo Genes that share compounds with CCNA2: view

Transcripts for CCNA2 Gene

mRNA/cDNA for CCNA2 Gene

Unigene Clusters for CCNA2 Gene

Cyclin A2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNA2 Gene

No ASD Table

Relevant External Links for CCNA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNA2 Gene

mRNA expression in normal human tissues for CCNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNA2 Gene

SOURCE GeneReport for Unigene cluster for CCNA2 Gene Hs.58974

genes like me logo Genes that share expressions with CCNA2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for CCNA2 Gene

Orthologs for CCNA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCNA2 35
  • 90.62 (n)
  • 90.7 (a)
CCNA2 36
  • 91 (a)
(Canis familiaris)
Mammalia CCNA2 35
  • 91.82 (n)
  • 91.44 (a)
CCNA2 36
  • 91 (a)
(Mus musculus)
Mammalia Ccna2 35
  • 86.65 (n)
  • 89.32 (a)
Ccna2 16
Ccna2 36
  • 87 (a)
(Pan troglodytes)
Mammalia CCNA2 35
  • 99.46 (n)
  • 99.54 (a)
CCNA2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ccna2 35
  • 87.85 (n)
  • 89.69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
-- 36
  • 60 (a)
-- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CCNA2 36
  • 71 (a)
(Gallus gallus)
Aves CCNA2 35
  • 68.21 (n)
  • 70.95 (a)
CCNA2 36
  • 68 (a)
(Anolis carolinensis)
Reptilia CCNA2 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccna2 35
  • 65.08 (n)
  • 64.91 (a)
Str.6336 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397933 35
(Danio rerio)
Actinopterygii ccna2 35
  • 65.03 (n)
  • 66.24 (a)
ccna2 36
  • 49 (a)
CCNA2 (2 of 2) 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycA 37
  • 49 (a)
CycA 35
  • 52.83 (n)
  • 49.8 (a)
CycA 36
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012413 35
  • 57.14 (n)
  • 56.43 (a)
(Caenorhabditis elegans)
Secernentea ZK507.6 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLN1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCA2;4 35
  • 47.65 (n)
  • 39.95 (a)
(Oryza sativa)
Liliopsida Os12g0502300 35
  • 51.94 (n)
  • 46.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10122 36
  • 58 (a)
Species with no ortholog for CCNA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNA2 Gene

Gene Tree for CCNA2 (if available)
Gene Tree for CCNA2 (if available)

Paralogs for CCNA2 Gene

Paralogs for CCNA2 Gene

(4) SIMAP similar genes for CCNA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCNA2: view

Variants for CCNA2 Gene

Sequence variations from dbSNP and Humsavar for CCNA2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs769237 -- 121,823,824(-) CCTGC(C/T)TGCGC utr-variant-5-prime
rs769238 -- 121,823,787(-) GGTCT(C/T)GAGCT utr-variant-5-prime
rs769239 -- 121,823,753(-) TAGGC(C/T)GGCCT utr-variant-5-prime
rs769240 -- 121,822,912(-) TAAAC(G/T)TGTCA intron-variant
rs769241 -- 121,821,142(-) CTATT(A/G)AACTA intron-variant

Relevant External Links for CCNA2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCNA2 Gene

Disorders for CCNA2 Gene

(97) Novoseek inferred disease relationships for CCNA2 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 85.9 86
tumors 61.1 132
cancer 57.9 58
breast cancer 47.1 50
superficial spreading malignant melanoma 46.8 1

Relevant External Links for CCNA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CCNA2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CCNA2 Gene

Publications for CCNA2 Gene

  1. Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. (PMID: 8647086) Higashi H. … Kitagawa M. (Eur. J. Biochem. 1996) 3 23
  2. B-Myb repressor function is regulated by cyclin A phosphorylation and sequences within the C-terminal domain. (PMID: 12673206) Petrovas C. … Sonenshein G.E. (Oncogene 2003) 3 23
  3. Cyclin A and the retinoblastoma gene product complex with a common transcription factor. (PMID: 1830372) Bandara L.R. … La Thangue N.B. (Nature 1991) 3 23
  4. Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. (PMID: 11598016) Fojas de Borja P. … Mudryj M. (EMBO J. 2001) 3 23
  5. Centrosome overduplication, increased ploidy and transformation in cells expressing endoplasmic reticulum-associated cyclin A2. (PMID: 11896577) Faivre J. … Sobczak-ThAcpot J. (Oncogene 2002) 3 23

Products for CCNA2 Gene

  • Addgene plasmids for CCNA2

Sources for CCNA2 Gene

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