External Ids for CCNA2 Gene
Previous HGNC Symbols for CCNA2 Gene
Previous GeneCards Identifiers for CCNA2 Gene
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNA2 Gene
CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include Fetal Valproate Syndrome and Retinoblastoma. Among its related pathways are Packaging Of Telomere Ends and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCND2.
UniProtKB/Swiss-Prot for CCNA2 Gene
Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.