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CCNA2 Gene

protein-coding   GIFtS: 71
GCID: GC04M122737

Cyclin A2


(Previous symbols: CCNA, CCN1)
  See CCNA2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin A21 2
CCN11 2 3 5
CCNA1 2 3 5
cyclin-A2
cyclin-A22
Cyclin-A3

External Ids:    HGNC: 15781   Entrez Gene: 8902   Ensembl: ENSG000001453867   OMIM: 1238355   UniProtKB: P202483   

Export aliases for CCNA2 gene to outside databases

Previous GC identifers: GC04M123663 GC04M123018 GC04M123130 GC04M123197 GC04M123096 GC04M122957 GC04M118464


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCNA2 Gene:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by
a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK
kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is
expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both
cell cycle G1/S and G2/M transitions. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCNA2 Gene:
CCNA2 (cyclin A2) is a protein-coding gene. Diseases associated with CCNA2 include tenosynovial giant cell tumor, and benign meningioma. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNE1.

UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248
Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Gene Wiki entry for CCNA2 (Cyclin A2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCNA2 gene promoter:
         TBP   CREB   TFIID   ATF-2   deltaCREB   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCNA2 promoter sequence
   Search Chromatin IP Primers for CCNA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCNA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q27

CCNA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCNA2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M122737:  view genomic region     (about GC identifiers)

Start:
122,737,599 bp from pter      End:
122,745,088 bp from pter
Size:
7,490 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248 (See protein sequence)
Recommended Name: Cyclin-A2  
Size: 432 amino acids; 48551 Da
Subunit: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex.
The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1),
interacts with SCAPER
Developmental stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis
Selected PDB 3D structures from and Proteopedia for CCNA2 (see all 81):
1E9H (3D)        1FIN (3D)        1FVV (3D)        1GY3 (3D)        1H1P (3D)        1H1Q (3D)    
Secondary accessions: A8K7B6 Q2M3U6 Q4W5P4 Q6LER8

Explore the universe of human proteins at neXtProt for CCNA2: NX_P20248

Explore proteomics data for CCNA2 at MOPED

Post-translational modifications: 

  • Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its
    degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity)1
  • Ubiquitination2 at Lys54
  • Modification sites at PhosphoSitePlus

  • See CCNA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001228.1  
    ENSEMBL proteins: 
     ENSP00000274026  
    Reactome Protein details: P20248

    CCNA2 Human Recombinant Protein Products:

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    OriGene MassSpec for CCNA2
    OriGene Custom Protein Services for CCNA2
    GenScript Custom Purified and Recombinant Proteins Services for CCNA2
    Novus Biologicals CCNA2 Proteins
    Novus Biologicals CCNA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCNA2
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCNA2 

     
    antibodies-online proteins for CCNA2 (10 products) 

     
    antibodies-online peptides for CCNA2

    CCNA2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CCNA2
    R&D Systems Antibodies for CCNA2 (Cyclin A2)
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    OriGene Custom Antibody Services for CCNA2
    Novus Biologicals CCNA2 Antibodies
    Abcam antibodies for CCNA2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCNA2
    antibodies-online antibodies for CCNA2 (142 products) 

    CCNA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCNA2 
    antibodies-online kits for CCNA2 (20 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013763 Cyclin-like
     IPR006671 Cyclin_N
     IPR004367 Cyclin_C-dom
     IPR015453 Cyclin_A
     IPR014400 Cyclin_A/B/D/E

    Graphical View of Domain Structure for InterPro Entry P20248

    ProtoNet protein and cluster: P20248

    1 Blocks protein domain: IPB006670 Cyclin

    UniProtKB/Swiss-Prot: CCNA2_HUMAN, P20248
    Similarity: Belongs to the cyclin family. Cyclin AB subfamily


    Find genes that share domains with CCNA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCNA2_HUMAN, P20248
    Function: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

         Genatlas biochemistry entry for CCNA2:
    cyclin A,complexing with CDC2,regulating late S and G2 phase of the cell cycle,putative up-regulated c-Myc target
    gene,

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019901protein kinase binding IEA--
         
    Find genes that share ontologies with CCNA2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CCNA2:
     Cell division defect  Increased G2M DNA content, inc  Increased cell death in DLD-1   Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccna2):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with CCNA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccna2tm1.2Pisc for CCNA2

       genOway: Develop your customized and physiologically relevant rodent model for CCNA2

    miRNA
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    miRTarBase miRNAs that target CCNA2:
    hsa-mir-132-3p (MIRT021865), hsa-mir-193b-3p (MIRT016556), hsa-mir-98-5p (MIRT027829), hsa-mir-24-3p (MIRT000119), hsa-mir-212-3p (MIRT024968), hsa-mir-197-3p (MIRT048136), hsa-let-7b-5p (MIRT003999), hsa-mir-146a-5p (MIRT004017)

    Block miRNA regulation of human, mouse, rat CCNA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCNA2 (see all 44):
    hsa-miR-548j hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidCCNA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNA2

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    Sino Biological Human cDNA Clone for CCNA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCNA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCNA2
    Addgene plasmids for CCNA2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCNA2

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13419) for CCNA2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCNA2_HUMAN, P20248: Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001939female pronucleus IEA--
    GO:0001940male pronucleus IEA--
    GO:0005634nucleus IDA16109376
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with CCNA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCNA2 About   (see all 42)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle Regulation of G1 S transition part 2
    Cell cycle Cell cycle generic schema 0.38
    Cell cycle ESR1 regulation of G1 S transition0.33
    Cell cycle Regulation of G1 S transition part 2 0.38
    G2 Phase0.00
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3IL-9 Signaling Pathways
    IL-7 Signaling Pathway0.40
    Development Thrombopoietin regulated cell processes0.38
    4CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    DNA Replication0.92
    Regulation of mitotic cell cycle0.94
    SCF(Skp2)-mediated degradation of p27/p210.86
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cyclin E associated events during G1/S transition0.86
    Switching of origins to a post-replicative state0.93
    Removal of licensing factors from origins0.86
    5Cellular Senescence
    Cellular Senescence0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    Cellular responses to stress0.81


    Find genes that share SuperPaths with CCNA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCNA2 (see all 9)
        Calpain Protease Regulates Cellular Mechanics
    TOB in T-Cell Signaling
    Breast Cancer Regulation by Stathmin1
    G1-S Phase Transition
    Estrogen-mediated S-Phase Entry

    1 Cell Signaling Technology (CST) Pathway for CCNA2
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CCNA2 (see all 10)
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Cell cycle Chromosome condensation in prometaphase
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Development Thrombopoietin-regulated cell processes
    Cell cycle Cell cycle (generic schema)

    Selected BioSystems Pathways for CCNA2 (see all 14)
        Cell cycle
    AMPK signaling
    IL-7 Signaling Pathway
    Id Signaling Pathway
    B Cell Receptor Signaling Pathway


    Selected Reactome Pathways for CCNA2 (see all 10)
        SCF(Skp2)-mediated degradation of p27/p21
    G0 and Early G1
    Orc1 removal from chromatin
    Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
    Senescence-Associated Secretory Phenotype (SASP)


    5 Kegg Pathways  (Kegg details for CCNA2):
        Cell cycle
    Progesterone-mediated oocyte maturation
    Hepatitis B
    Epstein-Barr virus infection
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNA2: 
              Cell Cycle in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCNA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCNA2 (P202481, 2, 3 ENSP000002740264) via UniProtKB, MINT, STRING, and/or I2D (see all 173)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
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    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007095mitotic G2 DNA damage checkpoint TAS1312467

    Find genes that share ontologies with CCNA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CCNA2
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCNA2

    Selected DrugBank Compounds for CCNA2 (see all 33)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol-- --target--10592235
    (2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol-- --target--10592235
    (2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE-- --target--10592235
    1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID-- --target--10592235
    1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE-- --target--10592235
    1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid-- --target--10592235
    2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE-- --target--10592235
    3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE-- --target--10592235
    3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL-- --target--10592235
    4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(4-Trifluoromethyl-Phenyl)-Amine-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for CCNA2 gene (see all 122)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    olomoucine 71.5 2 7925396 (1), 7549905 (1)
    roscovitine 61.5 1 18574471 (1)
    mimosine 58.5 6 1386764 (1), 1423313 (1), 10788489 (1), 7628532 (1) (see all 5)
    thymidine 53.5 16 9831241 (2), 15694027 (2), 8475104 (1), 15963470 (1) (see all 14)
    bromodeoxyuridine 52.7 35 11016684 (7), 9041174 (4), 10942581 (3), 8822203 (2) (see all 15)
    pstair 51 3 1533642 (2), 2143983 (1)
    flavopiridol 47.7 5 12467221 (1), 12457721 (1), 15185335 (1), 19603446 (1) (see all 5)
    aphidicolin 47.6 3 1423313 (1), 11282082 (1), 14738865 (1)
    butyrolactone i 42 1 9703910 (1)
    mg 132 38.4 2 15010833 (1), 15147952 (1)



    Find genes that share compounds with CCNA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCNA2 gene: 
    NM_001237.3  

    Unigene Cluster for CCNA2:

    Cyclin A2
    Hs.58974  [show with all ESTs]
    Unigene Representative Sequence: NM_001237
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274026(uc003iec.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CCNA2 (see all 44):
    hsa-miR-548j hsa-miR-607 hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-219-5p hsa-miR-29b-1* hsa-miR-508-3p
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCNA2
    Clone
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    OriGene ORF clones in mouse, rat for CCNA2
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    GenScript: all cDNA clones in your preferred vector: CCNA2 (NM_001237)
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    Addgene plasmids for CCNA2 
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    OriGene qPCR primer pairs and template standards for CCNA2
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      QuantiFast Probe-based Assays in human, mouse, rat CCNA2
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13419) for CCNA2 

    Additional mRNA sequence: 

    AK291931.1 BC104783.1 BC104787.1 CR407692.1 X51688.1 

    10 DOTS entries:

    DT.455397  DT.407371  DT.100796206  DT.95341715  DT.95341757  DT.100796211  DT.100648874  DT.121256957 
    DT.99965390  DT.101957287 

    Selected AceView cDNA sequences (see all 221):

    CR604810 AA580754 CR592551 BE313253 AI141961 BG421540 BU165700 BM478693 
    CA430513 BE889788 BX421177 CB132319 CB148121 AI624917 AI421226 BG031146 
    CA430303 D11598 AW575658 BQ888303 AA747548 BU902535 BM709790 BU733834 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCNA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCAAGATG
    CCNA2 Expression
    About this image


    CCNA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Double Negative 2 Thymocytes Thymus
             Bone marrow-derived hematopoietic stem cells (family)
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Early Ameloblasts Dental Enamel
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebellum
    CCNA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCNA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.58974
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCNA2: 
              Cell Cycle in human mouse rat
              Cellular Senescence in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CCNA2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccna21 , 5 cyclin A21, 5 86.65(n)1
    89.32(a)1
      3 (17.67 cM)5
    124281  NM_009828.21  NP_033958.21 
     365648665 
    chicken
    (Gallus gallus)
    Aves CCNA21 cyclin A2 68.21(n)
    70.95(a)
      396172  NM_205244.1  NP_990575.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCNA26
    cyclin A2
    74(a)
    1 ↔ 1
    5(139042537-139049515)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979332 cyclin A2 75.77(n)    X85746.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccna22 cyclin A2 78.73(n)   192295  AF234784.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CycA1 , 3 mitosis cyclin-dependent protein
    kinase, regulator3
    Cyclin A1
    49(a)3
    52.83(n)1
    49.8(a)1
      68E13
    393401  NM_001259795.21  NP_001246724.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYCA2;41 CYCA2;4 47.65(n)
    39.95(a)
      844377  NM_106686.2  NP_178153.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g05023001 Os12g0502300 51.94(n)
    46.18(a)
      4352280  NM_001073360.1  NP_001066828.1 


    ENSEMBL Gene Tree for CCNA2 (if available)
    TreeFam Gene Tree for CCNA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCNA2 gene
    CCNE12  CCND32  CCNO2  CCNB22  CCNE22  CCNB32  CCNB12  CCND12  
    CCNA12  CCND22  
    4 SIMAP similar genes for CCNA2 using alignment to 1 protein entry:     CCNA2_HUMAN:
    CCNA1    CCNB2    CCNB1    CCNB1V

    Find genes that share paralogs with CCNA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCNA2 (see all 146)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995244061,2
    C--122738801(+) CAGATA/TTAGTG 2 N Y mis10--------
    rs3759516621,2
    C--122738823(+) TTGAGC/G/TAGAGA 3 L syn10--------
    rs1998113921,2
    C--122738851(+) AAGTAA/C/GGGAAA 1 -- int11EU 1321
    rs1815200271,2
    C--122738854(+) TAGGGA/GAAAAA 1 -- int11Minor allele frequency- G:0.00EU 1321
    rs2014667751,2
    C--122738869(+) CATTTG/TTAGTA 1 -- int10--------
    rs32177761,2
    C,F,H--122738957(-) CAAGTC/TGGTCA 1 -- int15Minor allele frequency- T:0.00NS EA 578
    rs1148996571,2
    F--122738973(+) TTTAGA/GAACAC 1 -- int11Minor allele frequency- G:0.02WA 118
    rs32177751,2
    H--122738995(-) TGTGTG/ATTTCA 1 -- int15Minor allele frequency- A:0.00NS EA 578
    rs7692531,2
    C,H--122739090(-) GCYGTT/CCTCTA 1 -- int110Minor allele frequency- C:0.00NA MN NS EA 988
    rs32177741,2
    C,F,H--122739093(-) GAAGCT/CGTYCT 1 -- int110Minor allele frequency- C:0.00NS MN EA 966

    HapMap Linkage Disequilibrium report for CCNA2 (122737599 - 122745088 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCNA2: --
    Human Gene Mutation Database (HGMD): CCNA2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCNA2
    DNA2.0 Custom Variant and Variant Library Synthesis for CCNA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123835    OMIM disorders: --

    13 diseases for CCNA2:    
    About MalaCards
    tenosynovial giant cell tumor    benign meningioma    pleomorphic adenoma    thyroid lymphoma
    actinic keratosis    male germ cell tumor    giant cell tumor    smooth muscle tumor
    myxofibrosarcoma    laryngeal squamous cell carcinoma    meningioma    lung cancer
    breast cancer


    Find genes that share disorders with CCNA2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCNA2 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 85.9 89 15187102 (2), 19706764 (2), 1323816 (2), 14681231 (2) (see all 81)
    tumors 61.1 199 9500460 (5), 9815824 (4), 9796723 (4), 11277408 (4) (see all 99)
    cancer 57.9 69 14719102 (3), 14510182 (2), 8318919 (2), 19686820 (2) (see all 47)
    breast cancer 47.1 55 19706846 (5), 16823179 (4), 18665474 (4), 17201163 (3) (see all 30)
    superficial spreading malignant melanoma 46.8 1 11745687 (1)
    hepatocellular carcinoma 42.1 18 14606074 (2), 10408900 (2), 9500460 (2), 12408762 (2) (see all 14)
    carcinoma 41.6 49 11444193 (4), 9950254 (3), 12395374 (3), 17593077 (2) (see all 28)
    carcinoma squamous cell 40.3 27 12406568 (2), 19567385 (2), 11503976 (2), 12654186 (2) (see all 18)
    colon carcinoma 39.9 1 7601562 (1)
    colon cancer 38.6 1 20029639 (1)

    Genetic Association Database (GAD): CCNA2
    Human Genome Epidemiology (HuGE) Navigator: CCNA2 (9 documents)

    Export disorders for CCNA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCNA2 gene, integrated from 10 sources (see all 1343):
    (articles sorted by number of sources associating them with CCNA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. (PubMed id 21596315)1, 2 Huang X.... Dixit V.M. (Mol. Cell 2011)
    2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    6. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    7. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)
    8. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    9. SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. (PubMed id 17698606)1, 2 Tsang W.Y.... Dynlacht B.D. (J. Cell Biol. 2007)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 890 HGNC: 1578 AceView: CCNA2 Ensembl:ENSG00000145386 euGenes: HUgn890
    ECgene: CCNA2 Kegg: 890 H-InvDB: CCNA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCNA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCNA2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccna2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCNA2 gene:
    Search GeneIP for patents involving CCNA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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